In Baltimore City, youth ages 15-24 represented 70% of new STIs reported to the Baltimore City Health Department (BCHD) in 2012. Therefore, it is important to recognize youth perceptions on sexual health and how they relate to the messages they see and their testing experiences. This guide outlines possible design interventions, and recommendations for youth friendly sexual health messaging. This work was funded through the Centers for Disease Control and Prevention (CDC) grant “Community Advancements in the Reduction of Sexually Transmitted Diseases” (U22 PS004541-01), a collaboration between the Baltimore City Health Department (BCHD) , the Johns Hopkins Center for Child and Community Health Research (CCHR), and the Center for Social Design at Maryland Institute College of Art (MICA). For inquiries about use of interventions in other clinics, please contact Suzanne Grieb: sgrieb1@jhmi.edu