Bringing Next Level Intellectual Property to the Cannabis Industry

BY JESSICA WEBBER, DIRECTOR OF OPERATIONS, DEHYDR8

Dehyd8 LLC has licensed the rights of a pharmaceutical technology that provides pharma grade bioavailability cannabis to the Cannabis Industry.

Based in Science - Backed by StudiesSupported by Data

Dehydr8 develops all products based on a SEDDS technology (Self Emulsifying Drug Delivery System). SEDDS’s are scientifically proven to enhance oral bioavailability and are used in high-end pharmaceutical products. This elegant technology can be applied to the cannabinoid particles and active ingredients that are not water soluble as DehydraTECH™.

This patented process enhances oral bio-delivery of DeHydr8’s cannabis and hemp-based products, allowing the end user to reduce dosage without reducing efficacy, and provides for more consistent absorption and protection of the cannabinoids from the hostile environment in the gastrointestinal tract. The delivery process safely introduces cannabinoids into the system through the lymphatic system reducing or avoiding first pass liver metabolism. In a nutshell, the process ensures absorption of cannabinoid molecules directly into the bloodstream within minutes of ingestion or as applied to the skin, ensuring a faster and cleaner uptake though dermal, buccal, and sublingual exposure.

DeHydraTECH™’s quick absorption helps to solve the consumer issues of low bioavailability and solubility of many hydrophobic active pharmaceutical ingredients (API’s). Limitations in solubility lead to less solubilization in the gastrointestinal tract and absorption by the body. Many solutions, within the industry, have been used to overcome solubility concerns including the use of surfactants, lipids, permeation enhancers, micronization, salt formulations, cyclodextrins, nanoparticles and solid dispersions. Dehydr8 offers technology that does not need to rely on any of this, therefore creating a product that is clean, fast absorbing, and consistent.

Predictable and Enjoyable - What Consumers Want is What DehydraTECH Delivers

DehydraTECH™ has been developed to withstand the test of time; internal quality control used to infuse products have been produced repetitively with strict adherence to protocols. The company’s products meet strict accuracy and precision requirements measured, recorded, and monitored to ensure the consumer receives a predictable cannabis experience every time.

In addition to safe, fast, and predictable, the delivery system creates a more enjoyable experience for consumer without the weedy taste or smell that’s often found in cannabis products within the marketplace. The process almost completely masks unwanted organoleptic properties of both hemp and cannabis. Not only is the technology patent protected but flavor profiles are patent protected as well. DeHydr8’s technologically enhanced suite of SKU’s (over 500) are designed to provide consumers with all the benefits cannabinoids offer in a superior format.

The latest trend in cannabinoid delivery methods is “nano emulsion”. Nano technology essentially seeks to reduce the size of the cannabinoids particle and when combined with an emulsion, enhances dissolvability. But - does it enhance bioavailability? The answer is no.

The emulsion of choice or current industry standard uses a nano technology that usually employs a medium chain triglyceride (MCT) as a carrier. When the nano cannabinoid and emulsion combination break apart in the stomach, the cannabinoid is directed to the liver. The liver metabolizes up to between 85% and 95% of the cannabinoid, greatly affecting bioavailability of a nano product. Some nano technologies use Polysorbate 80, an emulsifier that has serious and known adverse effects on the mucous lining of the stomach among other undesirable side effects. Nano technology creates smaller particles in the manufacturing process, but once in the stomach these particles recombine to randomly different sizes and the rate of bio-absorption in the body depends on how much fat is in the consumer’s diet. Additionally, nano particles have been reported to create significant health concerns in areas of the body not designed for such wholesale particle size reduction.

In short, Nano-Tech products that include the addition of substrates and excipients are often inconsistent, unpredictable, and possess undesirable side effects.

DehydraTECH™ is not a Nano technology delivery system. Nano technology simply makes things smaller - DeHydr8 makes things simply effective with a SEDDS delivery system that enhances oral bioavailability, and gives the consumer a better tasting, more predictable, and faster-acting experience every time.

A Competitive Advantage in Cannabis Delivery

Dehydr8 LLC, with its extensive R&D, substantial cannabis knowledge and the licensed technology (IP), has led to the development of a multitude of form factors (and over 500 SKU’s). A comprehensive understanding of (ADME) Absorption, Delivery, Metabolism and Elimination has allowed DeHydr8 to master and develop a superior, technologically advanced drug delivery process creat6ing precision in (ADME), and consistency of dose that consumers can trust in.

Simply put, the pharmacokinetic technology found in all Dehydr8 products aids in delivering a host of competitive advantages including a clean product that creates a safer more effective and predictable cannabis experiences for consumers than what is currently found in the cannabis market.