Safer healthcare with Microbe Secure ongoing pathogen protection

Protect Your Patients from

with Microbe Secure™ Worlds first longacting pathogen protectant with verifiable performance.

Contents

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THE HACAI PROBLEM About the problem HCAI pathogens Transmission

THE VERIFIABLE SOLUTION 8 About the solution 10 Scientific proof 11 Compared to others 12 Top 10 benefits

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THE HCAI PROBLEM About the problem

Hundreds of millions of patients worldwide develop healthcare-associated infections (HCAIs) each year.1

Worldwide approximately 7% hospitalized patients will acquire at least one healthcare-associated infection.1

Patients with HCAIs cost 3 times as much to treat as uninfected patients.2

Prevelence of healthcare-associated infections in high-income countries (1995-2010).

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WHO, 2011 Plowman, 2001

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THE HCAI PROBLEM HCAI pathogens MRSA methicillin-resistant staphylococcus aureus • MRSA is one of the most important strains of antibiotic-resistant organisms, also known as “super bugs,” and is a common cause of hospital and community-acquired infections.3

• MRSA may linger on surfaces for weeks after patients have been discharged from the hospital even when the room has undergone recommended cleaning routines.6,7

• MRSA is involved in 9–10% of infections seen in intensive care units.4

• Patients admitted to rooms previously occupied by an MRSA-positive patient are at increased risk of acquiring the pathogen.6,8

• MRSA spreads via direct skin-to-skin contact, or by touching contaminated surfaces and objects.3,5

MRSA Risk of cross infection On Microbe Secure on-going antimicrobial surface

On unprotected surfaces

7 days - 7 months

Elimination within minutes

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VRE vancomycin resistant enterococcus • Enterococci are among the top five most common hospital-acquired pathogens.9,10

Patients admitted to rooms previously occupied by a VRE-positive patient are at increased risk of acquiring the pathogen.6,8,16

• I In Europe and the US, VRE is implicated in 4–5% of infections in intensive care units.11

• VRE can survive on medical equipment, bed rails, bedside tables.12-14

• VRE can linger in hospital rooms for some time after patients have been discharged, despite routine cleaning procedures.6

• Contamination from these environmental surfaces can play a role in the transmission of VRE.14-16

VRE Risk of cross infection On Microbe Secure on-going antimicrobial surface

On unprotected surfaces

5 days - 4 months

Elimination within minutes

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Haddadin, 2002 Vincent, 2009 Boyce, 1997 6 Huang, 2006

Hardy, 2006 Datta, 2011 Werner, 2008 10 Hidron, 2008

Vincent, 2005 Bhalla, 2004 Duckro, 2005 14 Livornese, 1992

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Kramer, 2006 Drees, 2008

THE HCAI PROBLEM HCAI pathogens Norovirus

• Norovirus is responsible for more than 80% of nonbacterial gastroenteritis outbreaks in Europe and the United States.17,18 • Outbreaks can spread rapidly and affect patients, personnel and visitors, and transmission can be difficult to control.19-21 • Norovirus is transmitted primarily through the faecal-oral route, either directly from person to person, or indirectly via contamination of food, or surfaces.22

• Norovirus infections are highly contagious. A very low infectious dose of less than 20 norovirus particles is sufficient to cause the spread of the infection.22 • Extensive contamination of environmental surfaces may result in prolonged norovirus outbreaks.20

Norovirus Risk of cross infection On Microbe Secure on-going antimicrobial surface

On unprotected surfaces

8 hours - 7 days

Elimination within minutes

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Acinetobacter baumannii • Acinetobacter baumannii, particularly multidrug-resistant forms, have been associated with numerous HCAIs.23

• Acinetobacter infection can prolong the length of hospital stay, and can be associated with an increased risk of death.23,25

• A. baumannii has been isolated from multiple surfaces and items of medical equipment in healthcare facilities (e.g. beds, bedcovers, sinks, countertops, door handles, computer keyboards, telephones, blood pressure cuffs, patient lifting equipment, supply carts, infusion pumps, respiratory care equipment, and cleaned reusable laryngoscope blades) in the vicinity of infected and colonized patients.23,25,27-32

• In addition to direct patient contact, environmental contamination plays an important role in the transmission of Acinetobacter species.26,27 • In a survey of 75 countries Acinetobacter was the sixth most common bacterial pathogen involved in infections in intensive care units.24

Acinetobacter baumannii Risk of cross infection On Microbe Secure on-going antimicrobial surface

On unprotected surfaces

7 days - 7 months

Elimination within minutes

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Lopman, 2003 Frankhauser, 2002 Navarro, 2005 20 Wu, 2005

CDC, 2009 CDC, 2011 Maragakis, 2008 24 Vincent, 2009

Simor, 2002 Morgan, 2012 Thom, 2011 28 de Gialluly, 2006

Wilks, 2006 Neely, 1999 Catalano, 1999 32 Borer, 2005

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Kramer, 2006

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THE HCAI PROBLEM Transmission 1

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How Pathogens involved in HCAIs are transmited in healthcare facilities

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Infected / colonized patients In healthcare settings, patients colonized or infected with pathogens frequently contaminate items in their immediate vicinity.34-36

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Healthcare workers can transfer pathogens from one patient to another by direct touch, or indirectly through having touched a contaminated object or surface with their hands or gloves.35-37

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Contaminated hands In busy healthcare environment 50% of healthcare workers fail to fully comply with recommended hand hygiene measures.38

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Touching objects 14 people can be contaminated by touching the same object one after the other.39

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Bures, 2000 Catalano, 1999 Boyce, 1997 37 Boyce, 2007

WHO, 2009 Rhenibaben, 2000 Kramer, 2006 41 Weber, 2010

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Hota et al, 2009

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Health associated infection pathogens Many antibiotic-resistant pathogens remain viable on surfaces for days to months.40,41

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Incomplete cleaning During terminal cleaning procedure as much as 51% of high touch surfaces may be forgotten or ignored.42

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End result Infections spread to susceptible patients through touching of contaminated surfaces or via contaminated hands.35-37

THE HCAI PROBLEM Transmission

Infected patients In healthcare settings, patients colonized or infected with pathogens frequently contaminate items in their immediate vicinity.43-45

Airborne contamination Airborne contamination of surfaces can occur if pathogens are released into the air (for example after coughing, sneezing or changing wound dressings) and then land on objects and clothes.46,47

Contaminated objects Clothing, beds, tables, handles, telephones, keyboards, monitors, stethoscopes, blood pressure (BP) cuffs/monitors and other equipment are often contaminated with bacteria and viruses.43,48,49

Healthcare workers Healthcare workers can also transfer pathogens from patients to inanimate objects and surfaces through touch.50,51

Blood pressure Cuffs BP cuffs are recognized as a potential means of transmission of nosocomial infections. In one study, 13% of BP cuffs used in the hospital were contaminated with potentially pathogenic bacteria such as MRSA.52

Pathogen survival Potential pathogens can remain viable on inanimate surfaces for days to months.53,54

Contaminated hands Hand hygiene is one of the most effective preventive measures. However, up to 50% of healthcare fail to comply with recommended hand hygiene measures.55

Contaminated surfaces Contaminated hands can sequentially transfer some viruses to up to seven surfaces, and 14 people can be contaminated by touching the same object one after the other.56

Bures, 2000 Catalano, 1999 Boyce, 1997 46 Best, 2010

Stucki, 2009 Cimolai, 2008 Duckro, 2005 50 Thom, 2011

Morgan, 2012 Gialully, 2006 Kramer, 2006 54 Weber, 2010

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WHO, 2009 Rhenibaben, 2000

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THE VERIFIABLE SOLUTION About the solution

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THE VERIFIABLE SOLUTION About the solution Each application of Microbe Secure™: 1

Transforms normal surfaces into antimicrobial surfaces, continuously neutralizing the pathogen threat in busy healthcare settings.

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Allows verification of treatment in order to facilitate infection control compliance, measuring intact treatment and proof of pathogen protection.

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Continues to inactivate pathogens for up to 30 days (as long as treatment remains intact).

Microbe Secure™ was developed to stop the transmission of HCAI Pathogens

3 steps to achieve ongoing pathogen protection.

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Clean the surface

Secure

Verify

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THE VERIFIABLE SOLUTION Scientific proof

JIS Z 2801 / ISO 22196 MGS, a UKAS-accredited laboratory, measured the long acting antimicrobial activity of Microbe Secure™ on stainless steel against clinically relevant pathogens; MRSA, VRE, Acinetobacter baumaani, Pseudomonas aeruginosa using the Japanese Industrial Standards testing method JIS Z 2801 (equivalent to ISO 22196).

MGS Laboratories, concluded in their technical report that “When applied onto stainless steel following the manufacturer’s instructions, Microbe Secure™ demonstrates antibacterial activity for up to 30 days, for the organism tested.”1

EN 13697 Hjelt-Institute, Laboratory of Hygiene and Microbiology, Dept. of Public Health, University of Helsinki, Finland, confirmed that Microbe Secure™ demonstrated at least a 4 log10 reduction in bacterial viable counts for Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and Enterococcus faecalis, as required by EN13697.2

DVV - Guideline of the German Association for the Control of Viral Diseases HygCen GmbH, an AKS_Akkreditierung laboratory in Germany, tested Microbe Secure™ in accordance with the Guideline of the German Association for the Control of Viral Diseases, DVV, concluding that Microbe Secure™ inactivated the enveloped Vaccinia virus strain within 5 minutes, demonstrating a >4 log10 reduction in viral titre as required by the guideline. This result means that Microbe Secure™ is considered to have virucidal activity against all other human pathogenic enveloped viruses, including Influenza viruses, Hepatitis B- and –C viruses and HIV.3

Verifiable evidence.

A technical report on the verification process produced by MGS Laboratories and based on JIS 2801 concluded that: “When applied onto stainless steel following the manufacturer’s instructions, the presence of Microbe Secure™ on a surface is verifiable using the indicator strips.” A result of 6 on the test strip indicates that Microbe secure™ is fully active (reduction in MRSA of >99.999%), while a result of 1 indicates that no Microbe Secure™ remains on the surface.4

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MGS1 Hjelt.Dept. of Public Health Hygcen.AKS. Akkreditierung .Germany 60 MGS3 57 58 59

THE VERIFIABLE SOLUTION Compared to the others

Comparison of cross contamination prevention methods Microbe Secure™

Alcohol-based

Chlorine-based

Hydrogen peroxide

Ongoing long-acting inactivation of bacteria and viruses

Ability to verify product activity

Cost saving potential

Safety

• Flammable • May damage rubber

• Risk of severe burns • May produce toxic fumes if mixed with other products • Corrosive to metals

• Toxic if inhaled or contact with skin and eyes occur • May bleach surfaces

Try Microbe Secure™ We invite you to trial Microbe Secure™ in your healthcare facility.

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The Top 10 benefits of Microbe Secure™ surface treatment 1

Applying Microbe Secure™ on common touch surfaces in hospitals can provide uninterrupted protection against disease-causing microbes for days, weeks, and even months.

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6 It may be easier to attract high quality staff when you have low rates of HCAIs.

PRO 50%

7 Reapplication of surface disinfectant only when necessary (as shown with test strips) reduces costs of labour and materials.

Effective prevention of HCAIs reduces deaths and increases chances of successful recovery for patients.

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8 Low rates of HCAI could improve the public image and reputation of your healthcare facility.

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9 Preventing just one bloodstream infection can save a healthcare provider up to €14,300.

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Microbe Secure™ is safe to use on any surface and safe to store. It is free of any toxic irritants and does not contain traditional heavy metals or poisons.

MICROBE SECURE LTD 2 Redhouse Square, Duncan Close Moulton Park NORTHHAPTON, NORTHAMPTONSHIRE England, NN3 6WL Phone: +44 (0) 1652641681 (8am to 4pm) Web: www.microbesecure.com

Applying Microbe Secure™ on common touch surfaces in hospitals can provide uninterrupted protection against disease-causing microbes for days, weeks, and even months.

Each Microbe Secure™ bottle comes with a colour-coded, ready-to-use test strip to verify the presence of Microbe Secure and help to avoid wastage and false protection.

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Microbe Secure™ MS71 has been rigorously tested and thoroughly proven.