Microbioz India September 2019 edition by Microbioz India,Laboratory Equipment,Magazines,Pharma and Healthcare News,Laboratory News

36 Cover Story 12 Dear friends and readers, I hope you would have enjoyed reading our previous issue. Once again, I am delighted to bring to you the September 2019 a special edition of Microbioz India magazine for distribution in Analytica Ancon India and Thailand Lab in the month of September 2019, supported by the cover story entitled “How Powder Testing Solutions Can Improve Product Quality and Manufacturing Efficiency” an Interview interaction with Tim Freeman, Managing Director-Freeman Technology (a Micromeritics company).

Featured article 44 Added to this, the current edition has a special featured guest article entitled “Diagnostic tools to detect date rape drugs worldwide” by Rebecca Scolastica Bello, focused on Date rape drugs which is a type of drug (stimulants, GHB, tranquilizers, opioids, Ketamine, LSD, analgetics, chloral hydrate, anaesthetics, psychedelics, deliriants, psyhoactives, hallucinogens) used to make rape or sexual assault, organ removal, kidnapping easier.

Product Launches

The edition also covers recent Pharma news articles and product launches collected from worldwide sources to update the readers with the current trends in the industry

The right chemistry for complementary materials

At this year’s All China Leather Exhibition (ACLE), which will take place from September 3 to 5, 2019, in Shanghai, China, specialty chemicals company LANXESS will present a new system offering for functional coatings under the name Pellart.

Delivering immunotherapy directly to brain tumors

The study, published this week on the peer-reviewed open access journal Nature Communications, demonstrated that a new type of nano-immunotherapy traversed the blood-brain barrier.

Automatic Continuous Online Monitoring of 32 Polymerization Reactions Testa Analytical Solutions e.K reports on the development and supply of key detector components for ACOMP, a smart manufacturing system by Fluence Analytics that continuously analyzes polymers during production.

Microbioz India, September 2019 09

ear friends and readers, I hope you would have enjoyed reading our previous issue. Once again, I am delighted to bring to you the September 2019 a special edition of Microbioz India magazine for distribution in Analytica Ancon India and Thailand Lab in the month of September 2019, supported by the cover story entitled “How Powder Testing Solutions Can Improve Product Quality and Manufacturing Efficiency” an Interview interaction with Tim Freeman, Managing Director-Freeman Technology (a Micromeritics company). The interaction includes discussion on multiple topics related with Powder testing and Characterization. It is estimated that up to 80% of manufactured products are handled in powder form at some point, extending powder processing capability is a major goal for industry as it works to improve manufacturing efficiency. While traditionally we have working with the well-established pharmaceutical sector, we are seeing rapid growth in additive manufacturing (or 3D printing). Here there is a growing appreciation of the need to optimize powder properties in order to exploit the full potential of this pioneering technology. Added to this, the current edition has a special featured guest article entitled “Diagnostic tools to detect date rape drugs worldwide” by Rebecca Scolastica Bello, focused on Date rape drugs which is a type of drug (stimulants, GHB, tranquilizers, opioids, Ketamine, LSD, analgetics, chloral hydrate, anaesthetics, psychedelics, deliriants, psyhoactives, hallucinogens) used to make rape or sexual assault, organ removal, kidnapping easier. We have the latest market research news and insightful product launches inside, collected from worldwide sources to keep you updated with what is going on in the industry. Dear friends and readers, I hope you find some value in the magazine. Also, I would like to thanks you for being together in this beautiful journey so far. We would love to have your valuable feedback and suggestions as they help us to come up with better content each time. For any further valuable addition, please write to us at editor@microbiozindia.com.

Disclaimer: This disclaimer informs readers that the views, thoughts, and opinions expressed in the Articles, Advertisements published in the magazine belong solely to author and advertisers and not neccesarility to the authors employer, organization, committee or other group or individual. The published material, adverts, editorials and all other contents published in Microbioz India magazine cannot guarantee and accepts no liability for any loss or damage of any kind of cause by this magazine and errors and for the accuracy of claims made by the advertisers.

Cover Story

How Powder Testing Solutions Can Improve Product Quality and Manufacturing Efficiency Tim Freeman, Managing Director at Freeman Technology (a Micromeritics company), discusses how using powder testing instrumentation can lead to improved product quality and manufacturing efficiency. reeman Technology focusses on powder characterization and how it can be used in process and product development. What are the typical industries you work with? Powders are utilized across a broad range of industries, and we work closely with customers to understand their individual powder handling challenges. This can range from pharmaceuticals, foods and powder coatings, to those processing ceramics and metal powders. It is estimated that up to 80% of manufactured products are handled in powder form at some point, extending powder processing capability is a major goal for industry as it works to improve manufacturing efficiency. While traditionally we have working with the wellestablished pharmaceutical sector, we are seeing rapid growth in additive manufacturing (or 3D printing). Here there is a growing appreciation of the need to optimize powder properties in order to exploit the full potential of this pioneering technology.

The fundamental mechanics that dictate this are consistent regardless of the specific application. However, the exact nature of the problems industry face can vary considerably. To provide context to this, filling is a common operation across all industries, however fill weights and tolerances vary widely. For example, the pharmaceutical industry often requires milligram doses to be filled accurately and at high speed, in order to meet stringent criteria and high throughput. By contrast, bulk chemical and mineral industries may process powders into 1-ton containers, employing a much longer filling process and without regulatory pressures. The factors that influence filling efficiency will depend on the type of equipment being used.

Do you see similarities in the problems your customers are trying to solve, or do they vary between industries? The majority of our customers come to us with similar challenges, irrespective of the industry in which they work. An overriding challenge is ensuring that powders perform consistently, whether as a finished product or during processing.

Group photo, Micromeritics

Microbioz India, September 2019 12

Cover Story Some systems are purely gravity driven, whilst others rely on force-feeding. In many applications, such as tablet manufacture on a rotary press, the powder fills the dies through a combination of gravity and force-fed flow. The influence of each of the two mechanisms will depend on the geometry of the feed frame, the flow rate through the press and the characteristics of the powder. It is easy to see, with wide variation in each of these variables that this is a complex process and remains challenging to model from knowledge of a limited number of particle properties and process parameters. At large scale, such as filling of bags or bulk containers, the process might be volumetric filling or one based on mass. In both cases it is typical that augers or rotary valves directly attached to the bottom of the feed hopper are employed. In this configuration, the factors that control filling efficiency may be different to those in tablet manufacture, however, efficiency across all scales and in all processes will depend on the compatibility of the material properties with the conditions imposed in the processing environment. Does the challenge of working with powders differ from working with liquids or gases? There are fundamental reasons why powders represent a greater challenge that liquids or gases. The understanding of how the properties of a liquid or gas influence behaviour within a process is well established. In contrast, the rheology of powders is a relatively ‘new’ concept as they typically exhibit more complex behaviour. As the diagram below shows, powders are bulk assemblies made up of particles, gases (normally air) and liquids (usually water). Each of these phases, and the interactions between them, will define bulk powder behaviour.

There are a large number of variables and particleparticle interactions which can influence powder behavior. As the image below demonstrates, these can relate directly to each particle such as size, shape, porosity, hardness, surface area, and others relating to the process or ‘external’ variables, such as moisture, surface charge or storage time.

Is it easy to gather data that will help customers understand how their powder will perform in a process, or a finished product? Powder testing has seen many changes over recent decades, with increasingly automated and more closely defined methods. This is helping customers to improve reproducibility of data and increase accuracy and reliability. However, it is critical to gather data that are relevant to understanding how a process or product will behave. Many techniques are limited, especially when attempting to replicate the performance of complex manufacturing processes. At Freeman Technology, we have worked with powders for nearly 20 years’ and have identified that shear, dynamic and bulk powder properties are the most valuable when solving industrial powder processing problems by providing process relevant data. Has the understanding of powders shaped the development of the FT4 Powder Rheometer®? What are the main benefits this product offers customers? The FT4 Powder Rheometer was designed specifically to characterize the rheology, or flow properties, of powders. It is considered a universal powder flow tester and used to solve problems associated with the industrial use of powders. It was developed in response to an increasing need to reliably measure properties that directly correlated with process and product performance. It differs from other powders testers in many ways, but when assessing industrial value, the following features are critical: Simulation of processing conditions – the FT4 tests samples in consolidated, moderately stressed, aerated, and even fluidized states Multi-faceted powder characterization – the instrument assesses dynamic flow, bulk and shear properties to construct the most comprehensive understanding of how a powder behaves

Microbioz India, September 2019

Cover Story Unparalleled sensitivity – enabling the differentiation of powders that other testers classify as identical Do you have examples where the FT4 Powder Rheometer has been used to solve industrial problems? Yes, the first example relates to tableting, a vital process for the pharmaceutical industry. Many pharmaceutical blends are granulated prior to tableting. This

helps prevent segregation of

the active

pharmaceutical ingredient (API), and delivers material optimized both for high throughput in the tablet press and finished tablet quality. We worked with the GEA Group to assess whether measurable granule properties correlate directly with critical quality attributes of the tablets produced, such as hardness. This work has been highly successful with the results demonstrating a strong correlation between tablet hardness and the Basic Flowability Energy (BFE) of the granules at various points during the wet granulation process. These results are valuable because they suggest that the wet granulation process can be optimized and controlled with reference to BFE data, rather than by working up every batch of granules to determine the quality of tablets they will produce. Potentially this accelerates the development and scale up of wet granulation processes, not least within the context of working towards continuous tableting processes. We are also working with a number of customers in the field of Additive Manufacturing (AM), this potentially transformative, highly efficient manufacturing technique, is increasingly used across a range of industries.

AM often involves ‘printing’ intricate components to a tight specification by gradually building up powder layers which are then selectively fused together. It is therefore critical to control the performance of powders in terms of process efficiency and end product quality. How a powder flows, and spreads into a thin layer, are defining aspects of this performance. The variability in feedstocks can lead to inconsistent bulk density, non-uniform layering, low tensile strength and poor surface finish. The ExOne Company has recently published how they are using the FT4 to assess every powder they use. ExOne use all three measurements offered by the instrument, dynamic, shear and bulk, to form their routine screening procedure. In terms of dynamic parameters, they use BFE, stability and flow rate index (FRI), all of which are generated by a single testing protocol. By correlating printing performance with data, they have been able to develop a robust specification for powders that perform well in process. For example, when considering a new supplier, or a customer provides a new powder to print with, ExOne are able to determine with a high degree of confidence whether that powder will work and if so how to process it, simply from the data the FT4 provides. good example of the benefits comes from a project to identify an alternative supply of 316L material. Metal powders are routinely purchased to deliver partprinting services and a significantly less expensive 316L powder supply was identified to try to reduce costs.

ExOne Binder Jetting Process (image courtesy of ExOne Company)

The particle size distribution of both powders was essentially the same – Dv50 of 15.8 c.f 16.1µm and comparable differences on Dv10 and Dv90 - as was the morphology.

Microbioz India, September 2019

Cover Story They found that printing with the new powder initially produced good results, but in subsequent runs with recycled powder, the quality diminished. Tests with the FT4 revealed that the stability of the two powders was remarkably different. The original powder has a stability of 1.03, meaning that flow properties are essentially unchanged with repeat testing, while that of the new supply is 1.52. The FT4 was able to detect powders that are insufficiently robust to retain consistent flow properties through the recycling process. Based on this result, a stability value of 1.2 now marks the upper limit of acceptability so powders that will fail in this way are detected prior to processing. ExOne Binder Jetting Process (image courtesy of ExOne Company) Author Information:

Tim Freeman is Managing Director of powder characterization company Freeman Technology for whom he has worked since the late 1990s. He was instrumental in the design and continuing development of the FT4 Powder RheometerÂŽ and the Uniaxial Powder Tester. Through his work with various professional bodies, and involvement in industry initiatives, Tim is an established contributor to wider developments in powder processing. Tim has a degree in Mechatronics from the University of Sussex in the UK. He is a mentor on a number of project groups for the Engineering Research Center for Structured Organic Particulate Systems in the US and a frequent contributor to industry conferences in the area of powder characterization and processing. A past Chair of the American Association of Pharmaceutical Scientists (AAPS) Process Analytical Technology Focus Group Tim is a member of the Editorial Advisory Board of Pharmaceutical Technology and features on the Industry Expert Panel in European Pharmaceutical Review magazine. Tim is also a committee member of the Particle Technology Special Interest Group at the Institute of Chemical Engineers, Vice-Chair of the D18.24 sub-committees on the Characterization and Handling of Powders and Bulk Solids at ASTM and a member of the United States Pharmacopeial (USP) General Chapters Physical Analysis Expert Committee (GC-PA EC).

Tim Freeman â&#x20AC;&#x201C; Managing Director, Freeman Technology (a Micromeritics company)

Business News

The right chemistry for complementary materials Systems for surface design and finishing Cologne – At this year’s All China Leather Exhibition (ACLE), which will take place from September 3 to 5, 2019, in Shanghai, China, specialty chemicals company LANXESS will present a new system offering for functional coatings under the name Pellart. “Our offering specifically does not use leather as a substrate,” stressed Dr. Rita Dicke, head of the OLC – Functional Coatings integrated business platform in the LANXESS Leather business unit. Dicke went on to explain that the aim was rather to make coating systems for the production of high-quality surfaces accessible to customers that process other substrates besides leather. For this purpose, LANXESS is bundling its many years of experience plus extensive application technology and analytical expertise in base products and additives to formulate such functional coatings. To make surface design as easy as possible for customers, LANXESS is offering individually developed system solutions that are ready to use immediately.

The requirements for the feel, gloss level plus temperature and abrasion resistance, simultaneously combined with the lowest possible concentrations of volatile organic compounds (VOC), are especially strict in this area. “This presents a particularly good opportunity for us to prove what we are capable of,” said Dicke, with confidence. Tailor-made for substrate, processing technology

Systematically high-quality surfaces It is an art to incorporating the many and varied options for the design of flexible surfaces in the formulation of a coating system. The fact that LANXESS experts have mastered this art lays the foundation for high-quality, customer-oriented intermediates and end products. The new Pellart products take this into account. An important area of application for such coatings is vehicle interiors, such as seats, door trims, roof linings and the surfaces of instrument panels.

application

and

The experience that LANXESS has been able to gain over decades of working with leather is an important basis on which to now develop impressive solutions for customers on other substrates using Pellart. Building on carefully designed and tried-and-tested basic formulations, these can promptly be made available to customers. In addition to various plastics – such as polyvinyl chloride (PVC), thermoplastic polyolefins (TPO) and polyurethane (PUR) – textiles are also of great importance as flexible coating carriers. Carrier layers made of microfibers, for example, achieve particularly attractive property profiles regarding haptics and durability. This is demonstrated by a low-VOC microfiber fleece for scooter seats that is coated using Pellart. Such a prototype will be on show at the LANXESS trade show stand at the ACLE. LANXESS is a leading specialty chemicals company with sales of EUR 7.2 billion in 2018.

Microbioz India, September 2019

Business News The company currently has about 15,400 employees in 33 countries and is represented at 60 production sites worldwide. The core business of LANXESS is the development, manufacturing and marketing of chemical intermediates, additives, specialty chemicals and plastics. LANXESS is listed in the leading sustainability indices Dow Jones Sustainability Index (DJSI World and Europe) and FTSE4Good. Forward-Looking Statements This company release contains certain forward-looking statements, including assumptions, opinions, expectations and views of the company or cited from third party sources. Various known and unknown risks, uncertainties and other factors could cause the actual results, financial position, development or performance of LANXESS AG to differ materially from the estimations expressed or implied herein. LANXESS AG does not guarantee that the assumptions underlying such forward-looking statements are free from errors nor does it accept any responsibility for the future accuracy of the opinions expressed in this presentation or the actual occurrence of the forecast developments.

No representation or warranty (expressed or implied) is made as to, and no reliance should be placed on, any information, estimates, targets and opinions, contained herein, and no liability whatsoever is accepted as to any errors, omissions or misstatements contained herein, and accordingly, no representative of LANXESS AG or any of its affiliated companies or any of such person's officers, directors or employees accept any liability whatsoever arising directly or indirectly from the use of this document. Information for editors:

All LANXESS news releases and their accompanying photos can be found at http://press.lanxess.com. Recent photos of the Board of Management and other LANXESS image material are available at http://photos.lanxess.com. You can find further information concerning LANXESS chemistry in our Web Magazine at http://webmagazine.lanxess.com.

Microbioz India, September 2019

Research News

Delivering immunotherapy directly to brain tumors A new study gives insight into how immunotherapies, treatments that help the body's immune system fight cancer, might one day be delivered directly to the brain in order to treat brain tumors. The study, published this week on the peerreviewed open access journal Nature Communications, demonstrated that a new type of nanoimmunotherapy traversed the bloodbrain barrier in laboratory mice, inducing a local immune response in brain tissue surrounding the tumors. The tumor cells stopped multiplying, and survival rates increased. For patients with glioblastoma, the most common and also most deadly form of brain cancer, immunotherapies like this could hold the key to longer survival, said Julia Ljubimova, MD, PhD, senior author of the study and professor of Neurosurgery and Biomedical Sciences at Cedars-Sinai. "This study showed a promising and exciting outcome," Ljubimova said. "Current clinically proven methods of brain cancer immunotherapy do not ensure that therapeutic drugs cross the blood-brain barrier. Although our findings were not made in humans, they bring us closer to developing a treatment that might effectively attack brain tumors with systematic drug administration." Harnessing the power of the body's own immune system to attack tumors is a concept that has intrigued investigators for decades. Scientists have been studying ways to persuade the immune system to attack tumors in the same way that it attacks, for example, a virus. While promising, this idea presents a few key challenges, especially when it comes to brain tumors. The environment of the brain can be hard to penetrate with drugs or other therapies.

The blood-brain barrier, which the body uses to naturally block toxins and other harmful substances in the bloodstream from getting into the brain, can keep out potentially lifesaving treatments. In addition, brain tumors seem to have the effect of suppressing their local immune systems. Tumors accumulate immunological guards such as T regulatory cells (Tregs) and special macrophages, which block the body's anti-cancer immune cells, protecting the tumor from attack, Ljubimova said. In order to allow tumorkilling immune cells to activate, investigators needed to find a way to arrest or deactivate the tumor-protecting Tregs and macrophages. Other immunotherapies have been successful in triggering an immune response in the whole body, which can slow the growth of tumors and extend the life of patients, but this treatment is one of the first of its kind to demonstrate the activation of both whole body and local immune systems around the tumor in laboratory mice.

Microbioz India, September 2019

Business News The immunotherapy tested in this study works by delivering checkpoint inhibitors, a type of antibody drug that can arrest and block Tregs and macrophages, so the tumor can't use them to block the incoming tumor-killing immune cells.Those checkpoint inhibitors are attached with a biodegradable polymer to a protein or peptide that enables the drug to traverse the blood-brain barrier.

"The horizon for treatment of brain cancer is getting clearer. We hope that by delivering multifunctional new-generation drugs through the blood-brain barrier, we can explore new therapies for many neurological conditions."Ljubimova says that further tests are needed before this therapy can be tested in humans.

"The checkpoint inhibitors can then block the Tregs and macrophages, allowing the local immune cells to get activated and do their job-fight the tumor," Ljubimova said.With the tumor-shielding cells blocked, immune cells like cytotoxic lymphocytes and microglial cells can then attack and destroy the cancer cells.

Materials provided by Cedars-Sinai Medical Center. Note: Content may be edited for style and length.

"Drug delivery is the major obstacle for the treatment of central nervous system diseases, including brain conditions," Ljubimova said.

Story Source:

Journal Reference: 1.

Anna Galstyan, Janet L. Markman, Ekaterina S. Shatalova, Antonella Chiechi, Alan J. Korman, Rameshwar Patil, Dmytro Klymyshyn, Warren G. Tourtellotte, Liron L. Israel, Oliver Braubach, Vladimir A. Ljubimov, Leila A. Mashouf, Arshia Ramesh, Zachary B. Grodzinski, Manuel L. Penichet, Keith L. Black, Eggehard Holler, Tao Sun, Hui Ding, Alexander V. Ljubimov, Julia Y. Ljubimova. Bloodâ&#x20AC;&#x201C;brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-01911719-3

Novartis selling manufacturing site to Chinese drug maker Another Novartis ingredient operation is being hived off as the Swiss drugmaker continues its drive to lop off manufacturing jobs to improve margins. This time it is selling an operation in China that it opened 10 years ago. Chinaâ&#x20AC;&#x2122;s Zhejiang Jiuzhou is buying most of Suzhou Novartis in Changshu, China, for 790 million yuan ($110.5 million), according to a Dow Jones report in Chinaâ&#x20AC;&#x2122;s Morningstar. The operation has about 340 employees. The Chinese company indicated it has an agreement to supply Novartis with ingredients. According to Dow Jones, the company said the deal will bolster its drug development and manufacturing capacities in China while improving its business prospects in Europe and the U.S. The company is known to the U.S. FDA, which slapped it with a warning letter in 2014 for selling relabeled ingredients that were not quality checked before being shipped.

It also was found to have data integrity issues. The Suzhou unit was opened by Novartis in 2009. According to reports at the time, the company had invested about $250 million in the three-building site, which also includes R&D facilities. It had big plans then for the unit to support its global production, but times have changed, and so has Novartis' outlook on manufacturing. Last year, CEO Vas Narasimhan announced the drugmaker had targeted about 2,000 manufacturing jobs that would be cut over four years as it transitions toward more complex biologics medicines and cell and gene therapies. But the sale also comes as Novartis is making a big push to sell drugs in China. During a conference in the country last year, Narasimhan told Bloomberg he wanted the company to more than double its sales there over the next five years. Story Source/Credit: by Eric Palmer in https://www.fiercepharma.com

Microbioz India, September 2019

Market Research

Global Adhesive Tape Market to Witness 5% Growth in CAGR between 2019-24 New Delhi: 02nd September 2019- According to the last study done on the global adhesive tapes market, the period 2017-2022 is expected to see a 6.68% growth in CAGR. Although the global market has responded well to the new key additions to the range of products in the adhesive segment, the Indian market is slowly moving toward the use of these new products. Noticing a Image Credit: Google Images gap in the current generation of an ineffective range of adhesive products, AIPL is extensively marketing the new market and are anticipated to continue doing so in the products with personalization in the marketing as that forecast period. Japan is one of the major markets for is the way forward in creating a better relationship with adhesive tapes, owing to the massive production of the target customers. appliances, and health care products. However, the There are industries that are showing healthy growth growing packaging industries in countries, like China, rates, AIPL will be focusing on expanding its product Japan, and India, are further expected to augment the range for these industries such as Packaging & Label, demand for adhesive tapes. From the above-mentioned Signage, HVAC, Surface Protection, White Goods, and factors, it is evident that the demand for adhesive tapes Electronic & Electrical industries among others. The is expected to further increase in the Asia-Pacific region fattened use of superior adhesives and sealants in over the coming years.â&#x20AC;? glazing and flooring applications is expected to fuel the Considering the burgeoning effects of environmental growth of the elastic adhesive market across the globe. issues, the adhesive tapes market has incorporated ecoThe adhesive tapes market commands the packaging friendly material in their production. industry; this command has opened new avenues to AIPL not only abides by the compliances but stays a various manufacturing sectors such as agriculture, step ahead in environment protection. We strongly pharma, retail, and FMCG among others. This is a great believe in protecting our environment for our good and value addition. for the good of generations to come. We have several Founder of AIPL Mr. Ajit Gupta said, â&#x20AC;&#x153;Recently, programs running in this direction. APAC countries have dominated the adhesive tapes

Pre Event Coverage

Gear up for Analytica Anacon India and India Lab Expo 2019 in Hyderabad – Quintessential shows for Pharma, Food and R&D 1. Optimum trade fair for the pharmaceutical, food processing, research and development industries in India 2. An array of 2500 brands will exhibit to an audience of approximately 10,500 visitors 3. Jointly held Pharma Pro & Pack Expo is gaining increasing momentum in the sector as well

The pharmaceutical industry has seen remarkable expansion in the past decade, globally and especially in India. According to India Brand Equity Foundation, the Indian pharmaceutical industry itself produces and supplies 50 percent vaccines, 40 percent generic medicine in the US and over 25 percent of all medicines in UK. Alongside pharmaceutical, food processing, research and development sectors are growing at an exponential rate as well. The Indian food processing industry accounts for 32 percent of the country's total food market and the Ministry of Ministry of Food Processing Industries is implementing a number of schemes for R&D in the Food Processing Sector additionally. Growing industries such as these require an optimum platform for industry professionals to come together, network and showcase their latest innovations. Analytica Anacon India and India Lab Expo are the ideal trade fairs for industry suppliers, manufacturers to exhibit their products to an extensive audience in India. To be held in Hyderabad from 19th to 21st September 2019, Analytica Anacon India and India Lab Expo will bring the best of the lab technology and analytical instrumentation to the pharmaceutical, food processing, research and development industry in India, under one roof. Hyderabad – The emerging hub of pharma, food and R&D sector Over the years, Hyderabad has emerged as the pharmaceutical hub of the country and is also known as ‘The Genome Valley of India’.

The research and development sector in Hyderabad is also gaining momentum. With an incredible number of food processing clusters emerging in the city, Hyderabad provides favourable grounds for Analytica Anacon India and India Lab Expo, for both: visitors and exhibitors. Analytica Anacon India and India Lab Expo – Bigger than before This year Analytica Anacon India and India Lab Expo gear up for an even bigger edition. A series of roadshows held across the country as a precursor to the shows are already bringing significant attention to the trade fairs. Supporting program BuyerSeller Forum gives buyers an opportunity to conduct one-on-one meetings with numerous sellers at the trade fairs. Analytica Anacon India and India Lab Expo also plan to bring in buyers from different cities across the country. This will enable sellers to reach out to a larger buyer group from various parts of India. With 300 domestic and international exhibitors estimated to showcase their brands at the show and over 10,500 visitors in attendance, the 14th edition is already gearing up to set new benchmarks. Microbioz India, September 2019

Pre Event Coverage Girija S. Brahma, Marketing Manager, MERCK Life Science Private Limited about the participation in Analytica Anacon India and India Lab Expo: “The trade fairs continue to be a great platform where we get opportunities to interact with the industry stakeholders, it definitely helps in building a strong presence within the analytical industry.” Pharma Pro&Pack – Exclusive event for pharma machinery solutions Analytica Anacon India and India Lab Expo, Pharma Pro&Pack is the only event in Hyderabad for pharma machinery technologies and solutions. Pharma Pro&Pack brings the best of the industry under one roof, giving industry professionals an ideal platform to showcase their latest innovations and empower their brands in the process. Extensive trade promotion program enables reaching out to the leading pharmaceutical companies, efficiently. About Analytica Anacon India and India Lab Expo

Analytica Anacon India addresses the rapidly growing Indian market with exhibition sectors for analysis, laboratory technology, biotechnology and diagnostics. It is being held in conjunction with India Lab Expo, one of India’s leading trade fairs for analysis, laboratory technology and biotechnology. The next events take place from September 19 to 21, 2019 in Hyderabad. About analytica worldwide Messe München is the world’s leading trade fair organizer for laboratory technology, analysis and biotechnology: Part of the analytica network are the trade fairs analytica China, analytica Anacon India and India Lab Expo in Mumbai and Hyderabad, analytica Vietnam and analytica Lab Africa. Messe München Messe München is one of the leading exhibition organizers worldwide with more than 50 of its own trade shows for capital goods, consumer goods and new technologies. Every year, a total of over 50,000 exhibitors and around three million visitors take part in more than 200 events at the exhibition center in Munich, at the ICM – Internationales Congress Center München and the MOC Veranstaltungscenter München as well as abroad. Together with its subsidiary companies, Messe München organizes trade shows in China, India, Brazil, Russia, Turkey, South Africa, Nigeria, Vietnam and Iran. With a network of associated companies in Europe, Asia, Africa and South America as well as around 70 representations abroad for over 100 countries, Messe München has a global presence.

Product Launch

Automatic Continuous Online Monitoring of Polymerization Reactions Testa Analytical Solutions e.K reports on the development and supply of key detector components for ACOMP, a smart manufacturing system by Fluence Analytics that continuously analyzes polymers during production.

ACOMP is an automated monitoring system that produces real-time data about reaction kinetics and polymer properties, including residual monomer, monomer conversion, polymer composition, molecular weight and intrinsic viscosity.

polymer yields, quality and consistency; optimize process control; and reduce cycle times and material usage,“ said Alex Reed, CEO of Fluence Analytics. Backed by decades of experience, Testa Analytical has created a range of high-performance GPC/SEC detectors, GPC/SEC Pumps, accessories and software products customizable to meet your exact needs. Our team of knowledgeable technical and engineering staff are available to discuss your OEM needs and to provide seamless integration of our technology into your existing or new product. Testa Analytical Solutions e.K. is a company dedicated to supplying the best possible instrumental solutions for characterization of polymers, particles, nanomaterials and proteins. Drawing upon over 30 years’ experience of technologies serving these markets, the staff at Testa Analytical are happy to share their knowledge with researchers worldwide to help provide them with a working solution for even the most demanding applications. Story source/Credit: TESTA Analytical Solutions

Separation and Characterization of Nanoplastics in the Environment

Postnova Analytics has published a new application note that demonstrates the promise of Electrical Asymmetric Field Flow Fractionation (EAF4) technology for separation and characterization of nanoplastics in the environment. Carlo Dessy, Managing Director of Testa Analytical said, "Fluence Analytics is a pioneering developer of novel analytics solutions for optimizing the efficiency and quality of polymer and biopharmaceutical production. Fluence Analytics selected us to to develop rapid scanning UV and differential refractive index detectors for ACOMP. Unlike many OEM projects we have worked on, this was not a chromatographic application. There is no separation involved. With the requirement for detection at higher flow rates, we had to adapt our standard UV and differential refractive index detectors. We also had to write new software for this polymerization monitoring application. “ "TESTA Analytical is a highly respected manufacturer of refractive index and UV detectors with an impressive record of designing innovative solutions to target challenging applications. TESTA Analytical’s support has enabled Fluence Analytics to help customers increase

Microbioz India, September 2019

Product Launch The widespread use of plastics has created one of the worst human-created environmental disasters of current times. Typically formed by the weathering and breakdown of plastic materials, small fragments of plastic smaller than a one micrometre in size (nanoplastics) have been found to be widespread in the environment. Nanoplastics are very difficult to isolate from their environment with simple methods, such as filtration, that can be used for larger size particles. Being submicrometre in size, nanoplastic particles can potentially penetrate tissues and therefore pose a significant environmental threat to marine life. However, many questions still need to be answered to establish just how dangerous nanoplastic particles really are, and a reliable method of analysis is a key requirement.

Compared to traditional â&#x20AC;&#x2DC;batchâ&#x20AC;&#x2122; analysis, where only a single average size and charge is given, this new Electrical Asymmetric Field Flow Fractionation (EAF4) technique offers great promise as a powerful tool for the accurate characterisation of nanoplastics in the environment. To request a copy of the application note please contact Postnova Analytics on +49-8191-985-6880 / +44-1885475007 / +1-801-521-2004. Story source/Credit: Postnova Analytics GmbH

Washing or Sterilizing Very Small Parts? World Precision Instruments has introduced a series of Micro Fine Mesh Baskets which are ideal for washing or sterilizing very small parts.

Nanoplastic particles have proven challenging to separate and characterize using traditional techniques such as dynamic light scattering or size exclusion chromatography. By comparison - Asymmetrical Flow Field-Flow Fractionation (AF4) may be the analytical solution for nanoplastics as it is a high-resolution separation technique proven for characterization of both monodisperse and polydisperse nanoparticle suspensions.

The authors of the new application describe how a mixture of two polystyrene particles was used as a test standard for a polydisperse nanoplastics system. This mixture was separated using the AF4 technique with an additional electrical field applied across the separation channel which separates the particles based on their charge polarity and magnitude. By using four different electrical field conditions, measurement of the electrophoretic mobility and thus the individual surface zeta potential of both particles in the mixture was determined. In addition, Multi Angle Light Scattering (MALS) was used as a detector to simultaneously collect information about the size of both particles.

The series of baskets consists of many sizes from 40 x 40 x 20 mm up to 180 x 130 x 20 mm. The Micro Fine baskets are constructed with micro fine mesh with opening squares of 1.0 mm and wire diameter of 0.5 mm. In addition to the Micro Fine Baskets, WPI also offers a series of Fine Mesh Baskets and a series of Perforated Baskets. The basket selected would be determined by the parts being cleaned or sterilized. These baskets are manufactured with 304 stainless steel that has been electrolyte polished. Each basket is provided with a lid with a wire locking clip. Story source/Credit: World Precision Instruments

Microbioz India, September 2019

Product Launch

Sphere Fluidics introduces latest version of Cyto-Mine Studio Software Suite Update offers new functionality to enhance workflows in biologics discovery and cell line development

Sphere Fluidics, a company commercializing single cell analysis systems underpinned by its patented picodroplet technology, has introduced an updated version of its Cyto-Mine® Studio Software Suite, a collection of software controlling operation of its Cyto-Mine Single Cell Analysis System, data acquisition and follow-up analysis. The latest software version includes new functionality to further enhance users’ workflows in biologics discovery and cell line development. Sphere Fluidics’ Cyto-Mine integrates selective screening of tens of millions of single cells, sorting, dispensing and imaging for clone verification into a single automated platform. The updated Cyto-Mine Studio Software Suite enables all assays to progress automatically from priming to the end of incubation, removing the need for user interaction during these steps.

Variable picodroplet generation numbers, ranging from 1–2 million may also be selected, and pooled picodroplet dispensing allows researchers to dispense all sorted picodroplets into a single well, providing more sample for further processing and analysis downstream. It also features a barcode scanner, which is compatible with many barcode systems, to facilitate picodroplet tracking. All data from detected, sorted and dispensed picodroplets are now saved in the local Cyto-Mine database along with experiment configuration parameters and assay results, allowing centralized archiving of experimental data and improved performance of the enhanced data analysis software. Experimental reports summarizing assay results and detailed information on

individual picodroplets and their content are also generated. Marian Rehak PhD, Vice-President of R&D at Sphere Fluidics, commented: “The flexibility of Sphere Fluidics’ Cyto-Mine platform makes it suitable for single cell analysis and monoclonality assurance across a variety of application areas. We’re continually striving to improve workflows for researchers and are pleased to introduce the latest version of our Cyto-Mine Studio Software Suite, particularly the pooled picodroplet dispensing functionality which supports the screening of an entire B cell population (obtained from an immunized mouse) twice to allow improved and faster selection of antigenspecific antibodies during antibody discovery.” Story source/Credit: Sphere Fluidics Limited

Microbioz India, September 2019

Product Launch

New Automated Viscometer for Chemicals RheoSense, Inc. has announced that the all new automatic VROC® initium Model II Viscometer is now available for viscosity characterization of any solvent-based solutions. High throughput and timely measurements are now easier and more productive. Accurate and precise viscosity measurement is assured with self-diagnosis leaving no uncertainty. The viscometer is powerful with its ability to measure intrinsic viscosity and true viscosity measurement even at high shear rates up to 148,000 (1/s) with minimal sample volume.

Sample recovery after measurement even helps save the precious sample for further analysis. Viscosity analysis of the sample for the process and quality control or product development is now a just push-button away. Samples placed in a vial rack or 96 well plate are automatically picked up and tested. Larger payloads of solvent bottles allows measurement of 96 samples with a single charge of solvents. Accompanying software, Clariti, provides advanced analysis of the viscosity data such as intrinsic or inherent viscosity, activation energy, injectability, comparison between lots, and report generation of all the advanced analysis. RheoSense, Inc. is the inventor of microfluidic/MEMS based viscometer chip VROC® and developer of a range of viscometers serving biopharmaceutical and industrial applications.

Bruker Introduces Next-Generation 80 MHz Benchtop FT-NMR System New Fourier 80 for High NMR Data Quality with TopSpin Software for Any Chemistry Lab At EUROISMAR 2019, Bruker has announced the European launch of the Fourier 80 system, a nextgeneration, high-performance 80 MHz Fourier Transform nuclear magnetic resonance (FT-NMR) benchtop spectrometer.

The Fourier 80 has been designed for organic or medicinal chemistry research, routine analysis, teaching or synthesis verification in any chemistry laboratory. Equipped with a novel, ultra-stable 80 MHz permanent magnet, it requires no cryogens, magnet power supply, water cooling or special laboratory infrastructure.

The Fourier 80 has been designed for highest data quality and stability at 80 MHz, with excellent lineshape, resolution and sensitivity in 80 MHz homonuclear 1H or heteronuclear 1H/13C FT-NMR experiments. It runs Bruker's TopSpin™ software, giving users access to the extensive TopSpin library of 1D and 2D homonuclear and proton-carbon heteronuclear experiments and pulse programs. In addition, the Fourier 80 offers the new, easy-to-use GoScan™ software module for NMR novice users.

Story source/Credit: RheoSense Inc

Microbioz India, September 2019

Product Launch

Individually Packed Sterile Assay Plates Porvair Sciences announces its complete range of Krystalâ&#x201E;˘ clear bottomed assay microplates is now available individually packed and sterilised for optimised tissue culture cell growth or non-sterile for assay development. Building upon Bruker's decades of experience in highfield FT-NMR, the Fourier delivers robust high performance in a compact and affordable benchtop system. The Fourier 80 makes NMR accessible in essentially any lab where chemists work. It can be installed on a bench or in a fume hood without the need for new infrastructure, with easy maintenance and minimal cost of ownership. Novice NMR users can use pre-defined GoScan experimental options, while experienced users or lab managers can use Bruker's industry-standard TopSpin software to access additional acquisition parameters, or advanced processing options. The Fourier 80 offers workflows and protocols for academic, pharma and industrial chemistry research, forensics and organic synthesis control. It can be incorporated into chemistry education to introduce students to the power of FT-NMR. An optional teaching package with recommended experiments and spectra interpretation guidance is available. Dr. Falko Busse, Group President of Bruker BioSpin, commented: "The Fourier 80 can now offer 80 MHz high-performance, affordable FT-NMR capabilities to any chemistry laboratory, with a compact footprint, easy siting, as well as low maintenance and training requirements. High-quality FT-NMR can now be used routinely in any organic chemistry lab, just like benchtop mass spectrometers or FT-IR systems have proliferated in chemistry for decades. The Fourier 80 extends the reach of FT-NMR into many chemical or pharmaceutical industry markets where fast, reliable answers are paramount. Its education package gives undergradutate instructors the tools to introduce young scientists to the power of FT-NMR. With the Fourier 80 we further 'democratize' the many applications of FT-NMR in chemistry." Story source/Credit: Bruker BioSpin

Available in a choice of 24-, 96- and 384-well formats, Krystalâ&#x201E;˘ series clear bottom assay plates are widely recognised as industry-leading cell culture tools by many Pharma drug discovery and screening labs. These standard clear polystyrene bottom plates have bases just 0.4mm thick and are moulded from highly polished tools to reduce flow lines, artefacts and scratches, guaranteeing excellent results with all types of bottom-reading instruments.

For more demanding applications, precision engineered Krystal glass bottom plates from Porvair Sciences are manufactured using a polystyrene upper and a borosilicate glass sheet fixed to the base with a biocompatible adhesive. This proprietary process results in consistent flatness (+/- 15 microns) across the base, excellent light transmission and a flat optical plane for growing cells. Based upon a standard SBS / ANSI microplate format - Krystal glass bottom plates are fully compatible with all confocal microscopes as well as automated liquid handling and robotic devices.

Story source/Credit: Porvair Sciences Limited

Microbioz India, September 2019

Product Launch

Creative Diagnostics Launches New Magnetic Beads Modification Service With years of experience in the pharmaceutical and life science sector, Creative Diagnostics recently releases custom services for magnetic beads modification, including surface coating and functionalization.

beads modification services that suit customers' specific requests and research programs in good time and budget. "Our experienced scientists are proficient in coating magnetic beads with various materials including silane, gold and polymers. For polymers, we have PEG, chitosan, dextran, PEI, as well as copolymers. So customers can easily find what they need at Creative Diagnostics. We'll also provide more access to accelerate bio-research by providing goods and services critical to researchers." said Dr. Jessica Waldorf, chief scientific officer of R&D department, at Creative Diagnostics. "Creative Diagnostics believes that improved understanding of magnetic beads modification is quite important for bio-researchers and to the bio-industry. Our magnetic beads modification services enhance cell isolation, RNA/DNA extraction, and protein purification. Creative Diagnostics is excited to make efforts to support the biotech industry." stated Alex, one of a senior scientific officers at Creative Diagnostics. For more detailed information on magnetic beads modification services or to request a proposal, please contact Creative Diagnostics directly at 1-631-619-7922 or email to contact@creativediagnostics.com. Youâ&#x20AC;&#x2122;ll find more about their newly released products.

Story source/Credit: Creative Diagnostics

The new magnetic beads modification services ensure low beads agglomeration, high dispersity, various active groups, including amine, carboxyl, sulfhydryl, aldehyde, and active hydrogen functional groups, and highly improved conjugation with a wide variety of affinity ligands, such as antibody, biotin, streptavidin, lectin, protein A/G. Creative Diagnostics' beads modification services include polymeric coating and functionalization. It offers custom beads coating with various materials including silane, gold and polymers. These coating materials can be functionalized with terminal active groups for conjugation with biomolecules, which enables the new services to be applied in cell isolation, RNA/DNA extraction, and protein purification. Creative Diagnostics is one of the leading suppliers and manufacturers of immunoassay products and services. With its experienced Ph.D level scientists and project managers, Creative Diagnostics can deliver the highest quality magnetic

Easy-to-Clean Laboratory Flowmeter Rugged, clean bore Polyether Ether Ketone (PEEK) and 316 Stainless Steel or glass construction makes the Atrato ultrasonic flowmeter from Titan Enterprises ideal for a wide range of laboratory applications and very easy to clean between experiments. Widely proven to handle flows from laminar to turbulent (2 ml/min to 20 litres/min), and largely immune from

Microbioz India, September 2019

Product Launch viscosity, the Atrato ultrasonic flowmeter is a perfect non-invasive tool for almost any laboratory flow metering application. No moving parts mean that the Atrato delivers highly reliable operation even over extended periods of time. The Atrato offers true inline non-invasive flow

manufactured to ISO9001 and calibrated to an uncertainty of ±0.25%. Story source/Credit: Titan Enterprises

measurement without the contorted flow path and disadvantages of alternative ultrasonic flowmeter designs. Available in 60°C and 110°C temperature versions as well as a 30 bar higher pressure model Atrato flowmeters use proprietary ‘time-of-flight’ ultrasonic technology that enable them to operate over wide flow ranges with accuracy better than ±1.0% of reading. Supplied as standard, Atrato flowmeter software enables data recording via an external computer. With features that provide monitoring, reporting and management of flow data - the Atrato flow software delivers a continuous picture of your experiment and a reliable alternative to restrictive and costly manual metering. Users can select from a wide variety of functions and time periods over which to store their results. Flow data sets are saved as .csv files which can then be imported directly to a wide range of programmes for later manipulation and analysis. Drawing upon over 40-years of flowmeter innovation Titan Enterprises Ltd are a manufacturer of highperformance solutions including the Atrato ultrasonic flowmeter, Oval Gear flowmeters, low flow Turbine flow meters and a flow instrument range. Titan’s company philosophy of “pushing the envelope by trying to do things a little different and better” has resulted in sales of over 1,000,000 products into 50 countries worldwide and a repeat purchase percentage of 95%. All flow meters produced by Titan Enterprises are designed and

Innovative Miniature Solenoid Valve Offers High Flow, Low Power, Low Leakage & Long Life A new generation of versatile and innovative 3-port solenoid valves which offer the combination of high flow rates, low leakage and low power consumption in a miniature 10mm package have been introduced by miniature component specialists THE LEE COMPANY. The novel genvi™ solenoid valve has been designed and manufactured using innovative techniques and represents a range of valves which provide outstanding

Microbioz India, September 2019

Product Launch application versatility and unmatched reliability at an economical price point. One of the key objectives in developing the genvi solenoid valve was to challenge the limitations of current fluidic technologies by allowing designers to use a miniature, low power solenoid valve, without compromising system-level flow rate requirements.

As a result the valve is capable of achieving minimum flow rates of 30 to 40 SLPM at 15 psid and its spike and hold profile results in ultra-low power consumption (318mW) during continuous duty operation on air and compatible gas applications. Crucially, this reduces system-level heating and improves battery life making it ideal for applications with challenging power budgets.

Here charges are developed when fluids are passing through silicone hoses or due to electrical induction when tubes are close vicinity of some electrical instruments in medical, pharmaceutical, hospital sectors. As silicones elastomers are insulator so that accumulated charges are stagnant followed by catastrophic static discharge leads to a fatal accident. This fatal accident comes with outputs like static shock or fire hazards. So removal of static charges are very important in those critical areas. Antistatic transparent tube is most challenging area of development. Industries are developed antistatic transparent hoses. This hose is transparent as well as it can dissipate static charges if charges are developed due to friction or induction.

Figure 1 Antistatic transparent hose

In addition to high flow, low power consumption, minimal leakage and extended life of at least 25 million cycles, genvi valves are designed to provide response times of less than 10 ms in applications with an operating temperature range from 40ยบF to 120ยบF. Typical applications for the valves include molecular diagnostics, oxygen delivery, environmental monitors, compression therapy, breath analysers or wherever high flow and low power cannot be sacrificed for size and reliability.

Story source/Credit: Lee Products Ltd

Antistatic Transparent hose by Ami polymer Pvt Ltd Now a days Silicone elastomer based hoses are widely used mostly in the area of medical, pharmaceutical, biological, biotechnical, artificial cell culture industries due to its cent percent biocompatibility, high and low temperature resistance, solvent resistance properties, high pressure flow of aggressive liquids and low leachability. The problem with conventional silicone hoses is the development of static electricity due to friction. A static electric charge is developed whenever two adjacent surfaces are in frictional contact.

Figure 2 Antistatic transparent hose

This transparent antistatic hose use both in high pressure application and as well as to reduce static discharge failure. Also transparency gives aesthetics look.

For more information: Ami polymer Pvt Ltd By: Pritam Adhikary (Executive-R&D) Ami Polymer Pvt. Ltd. # +91 82389 22236 research@amipolymer.com

Microbioz India, September 2019

Product Launch

BOD Incubator by Mack Accelerated Synthesis Pharmatech Pvt Ltd of Uniform High Purity Mack Pharmatech offers cost effective PLC based Substances BOD Incubator with European standard “CE” in different capacities.

BOD Incubator have Temp. range is 10°C to 60°C, Accuracy: ±0.2°C, Uniformity: ±1.0°C Control System: PLC (Allen Bradly) Mack Pharmatech is the only company who gives all equipment with PLC Based Control System,21 CFR Software, Touch Screen Display[HMI], Stand by Refrigeration System, PT 100 sensor, GSM Technology, Hooter System, Password protected door system, GMP Model, Full View Glass Door, Bullet feet leveling legs, Tray Spacing every ½ Adjustable and many more features.

For more Information: Mack Pharmatech Pvt ltd Corporate / Factory Office : B-48, Malegaon MIDC, Sinnar, Dist.-Nasik, Maharashtra 422 113, INDIA Mobile : +91 93259 65656 Telefax : +91-02551-230877 URL : www.mackpharmatech.com E-Mail : sales@mackpharmatech.com

These patented design chemical reactors use a jacketed cylindrical vessel with a central, rotating agitation bar to produce Taylor flow mixing along the length of the vessel resulting in 3-times faster mass flow transfer compared to tank type reactors. Reagents are pumped at a controlled rate into the vessel and the reaction efficiency is optimised through specific turbulent mixing before the products are collected at the end of the vessel.

The fluid flow in a LCTR system is a uniform Taylor fluid flow without dead-zones, consequently scale-up from 0.02 L to 1000 L can be routinely achieved to produce products with enhanced properties (purity, density, particle distribution, particle size, degree of crystallization etc.) and at higher yields compared to traditional reactors. Combining powerful agitation with uniform Taylor fluid flow in an LCTR system allows reaction times to be significantly reduced and productivity enhanced. Precise temperature control is achieved using a small diameter pipe design to facilitate thermal transfer and to maintain control and stability using a dual jacket. Each system includes a real-time monitoring system enabling you to follow the progress of your reaction in real time, and if a problem occurs, you can stop the process automatically. The LCTR-Series has also been designed to be simple to operate to enable users to quickly gain the full benefits of the powerful chemical reactor. Applications that have already benefited from LCTR systems include pharmaceutical API crystallisation, amino acid purification, graphene oxide manufacture, Lithium ion matter material production, recrystallisation to increase purity and OLED material production. Story source/Credit: Analytik Ltd

Microbioz India, September 2019