MUSC NeuroNews December 2012

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Medical University of South Carolina Neurosciences

Techniques- S-EEG Testing pg.

Volume 5 • Issue 3 • December 2012

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"MUSC first in SC to offer S-EEG testing for identifying the epileptogenic zone."

© 2012 Medical University of South Carolina. All rights reserved.

For questions or comments contact Emma C. Vought, MS (vought@musc.edu) www.MUSC.edu/neurosciences

"S-EEG"

Cover Image by Emma C. Vought

This newsletter is made possible from the generous contributions of MUSC's neurosciences faculty and staff. The success of this publication is dependant upon this support. Thank you for your interest, time and information. For inquiries, suggestions or submission information please contact Emma C. Vought, MS (vought@musc.edu).

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Š 2012 Medical University of South Carolina. All rights reserved.

Table of Contents Chairs' Message

1

Events

2

Featured Story

3

News

4-8

Publications

9-10

Clinical Trials

11-16

Employee Update & Social News

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CHairs' Message

Executive Editors:

Peter Kalivas, Ph.D. Bruce Ovbiagele, M.D., MSc Sunil Patel, M.D. Editors:

December, 2012

De a r Colleagues and Friends : It is a privilege and pleasure to have officially become a member of this outstanding Department.

For me, the past 4 months have been exhilarating, informative, and gratifying. I have enjoyed the warm welcome and kind words I have received (and continue to receive) from all of you. One could not ask for a better group of people to work for and with, and as a result I have settled in comfortably. Thanks!

While I was not in the Department for most of the year, I am aware that several new faculty and employees have arrived since last year bringing their profound talents and diverse experiences with them, thereby enriching our collective expertise and boosting the clinical, research, and educational trajectories of our Department. Welcome!

As we reflect on this passing year, there are numerous Department accomplishments in which to revel.

Just since I have been here we finally moved into the third floor of CSB, Drs. Adams and Chimowitz were announced as separate 2013 winners of major international awards recognizing their pre-eminence in stroke research, and the Institute for Applied Neurosciences (IAN) became a reality, to name a few. Furthermore, ably supported by terrific administrative staff, our providers continue to provide cutting edge care for patients with neurological diseases, and our programs continue to be well funded with national and international reputations for basic, clinical and translational research. In this newsletter we highlight many of these laudable activities and celebrated individuals. Congratulations!

Looking ahead there will be challenges including accommodating continued implementation of health care reform, dealing with uncertainties about State Support, decreasing clinical reimbursements, increasingly tight NIH/ Private foundation/health care society funding, patient access issues, and of course our evolving status as a mega-department. Each of these issues (and others) will represent opportunities for us all to come together and innovate our way to success. Given the caliber of our faculty, medical housestaff, and administrative staff and our strong commitment to excellence, there is reason for tremendous optimism. Indeed, it would seem our best year(s) are ahead of us!

Rachel Beard, BS Emma Vought, MS Illustrations and Design:

Emma C. Vought, MS Submission Staff:

Rachel Beard, BS Emma Vought, MS

Dr. Peter Kalivas Research Chair, Neurosciences

Wishing all of you happy holidays and the very best for the New Year!

Cheers, Bruce

Dr. Bruce Ovbiagele Neurology Chair, Neurosciences

Dr. Sunil Patel

Neurosurgery Chair, Neurosciences

Events

Neurosci enc es Feat ured Eve n t s January 18, 2013 - Hockey Heroes For Epilepsy

Join MUSC, the South Carolina Advocates for Epilepsy (SAFE) and the South Carolina Stingrays for Epilepsy Awareness Night. Bring your family and friends out for a night of action-packed hockey and fun. A silent auction will help raise money for REEF (Research and Education in Epilepsy Fund) at MUSC and SAFE. Ticket will be available for purchase on Jan. 2 & 16, 11 am to 2 pm, next to the MUSC's main hospital cafeteria, or by calling 843-744-2248 (ask for Mary Ann).

To find out more visit www.scepilepsy.org

March 21-23, 2013 - 12th Annual Pediatric Neuroscience Update

This event will take place at the Kiawah Island Resort, SC. This conference is designed for practitioners who are responsible for treating children with neurological, neurodevelopmental, and neurobehavioral disorders. It will include the latest in the management of these conditions, focusing on headaches, neurodevelopmental disorders, and epilepsy. Credits offered: AMA PRA Category 1 Credit(s); CEUs (Continuing Educational Units).

For more information contact the MUSC Office of CME at 843-876-1925 or www.MUSC.edu/cme.

To find out more about Neurosciences events visit:

www.MUSC.edu/neurosciences/events

cme Progress Notes- online cme eligible articles Aging Research Day March 8, 2013

9th Annual Aging Research Day "Maintaining Cognitive Health with Aging, Healthy Aging and Age-Related Disorders"will take place 8:30 am to 5:30 pm, at Founders Hall in Charles Towne Landing. The plenary speaker will be Mary Sano, Ph.D., Professor of Psychiatry, Director of the Alzheimer's Disease Research Program, Mount Sinai School of Medicine, Director of Research and Development, Bronx Veterans Administration Hospital.

To register or find out more visit www.scarn.org

Did you know you can now get AMA PRA Category 1 Credit(s)TM for reading an article in Progress Notes? To visit the Progress Notes web site, click on the below link. http://academicdepartments.musc.edu/cme October/November 2012 - In the Stroke of Time: Increasing Timely Access to Acute Stroke Care Through Telestroke July/August 2012 - Into Safe Hands: Appropriately Referring Pediatric Burn Patients to a Regional Burn Center for Improved Outcomes April/May 2012 - Responding to the Pediatric Obesity Epidemic: Should We Treat Children Like Adults?

9th Annual Aging Research Day

Maintaining Cognitive Health With Aging Healthy Aging and Age-Related Disorders

March 8, 2013

February 2012 - The SAMMPRIS Trial: PTAS and Aggressive Medical Management vs Aggressive Medical Management Alone in Patients With Severe Intracranial Arterial Stenosis You can complete the steps necessary to receive your AMA PRA Category 1 Credit(s) TM by visiting MUSC Health’s Physician Portal at physicianportal.muschealth.com.

Credit Designation: The Medical University of South Carolina designates this enduring material for a maximum of 0.50 AMA PRA Category Credit(s) TM. Physicians should only claim the credit commensurate with the extent of thier participation in the activity.

Accreditation Statement: The Medical University of South Carolina is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

8:30 am - 5:30 pm | Founders Hall at Charles Towne Landing To find out more or to register visit:

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www.scarn.org

Disclosure Statement: In accordance with the ACCME Essentials and Standards, anyone involved in planning or presenting this educational activity is required to disclose any relevant financial relationships with commercial interests in the healthcare industry.

Authors who incorporate information about off-label or investigational use of drugs or devices will be asked to disclose that information at the beginning of the article.

Medical University of South Carolina Neurosciences | neuronews

Feature Story

MUSC f irs t in S out h C a ro li n a t o o ffe r S - E EG t e s t i n g fo r i denti f ying t h e epil ept o g e n i c z o n e November 20th, 2012, MUSC Blog

November was epilepsy awareness month and MUSC’s Comprehensive Epilepsy Center is pleased to announce a new procedure, S-EEG that will improve surgical outcomes for epilepsy patients .

In patients with intractable focal epilepsy, surgery to remove the portion of the brain associated with the onset of the seizure can eliminate or greatly reduce the number of seizures a patient experiences.

For surgery to be successful, the epileptogenic zone (EZ), that area of the brain that is generating the seizure and the removal of which will cause the seizures to cease, must be precisely localized prior to the resection.

In some patients, noninvasive tests provide sufficiently consistent findings to localize the EZ and proceed directly to surgery.

Noninvasive tests include imaging such as magnetic resonance imaging, positron emission tomography, and single-photon emission computed tomography; scalp electroencephalography (EEG); careful observation of the semiology of the seizure (ie, clinical manifestations of the seizure providing clues to its area of onset) and functional neurological testing to identify any deficits in memory, attention, concentration, speech or language. However, in patients with conflicting or inconclusive findings on initial noninvasive studies, invasive intracranial EEG, where the electrodes are placed inside the brain, may be required to better delineate the EZ. In America, the preferred means for invasive EEG has been the placement of subdural electrodes, especially a grid or strip of superficial electrodes or individual depth electrodes. The grid of electrodes requires craniotomy (the opening of the skull) for placement. In Europe, however, stereoencephalography (S-EEG), which does not require craniotomy, has long been the norm, and recent articles suggesting improved outcomes with S-EEG1 has drawn new interest by American epileptologists and neurosurgeons. Jonathan C. Edwards, M.D., Director of the Comprehensive Epilepsy Center and Chief of the Division of Neurology, and Steven S. Glazier, M.D., Director of Pediatric Neurosurgery and Surgical Director of the Comprehensive Epilepsy Center, recently traveled to Montreal for a special training session with European experts in S-EEG and are offering this new means of localizing the EZ before surgery to patients at MUSC. Stereo-EEG allows for the precise placement of depth electrodes to monitor the activity of deeper structures of the brain that could be involved in the EZ or in the propagation of the seizure. Very careful measurements are made of the areas of interest on high-resolution magnetic resonance imaging using software specialized for the purpose. The patient is then placed into the stereotactic head frame (figure 1) so that the spatial coordinates can be marked and the actual trajectories of the electrodes to be implanted can be planned.

In the operating room, the neurosurgeon bores a series of 2-mm holes in the skull using a twist drill; into each a single electrode is inserted and secured with a bolt. Often a robot or other computerized system programmed with the spatial coordinates and electrode trajectories places the electrodes.

Figure 1

Once implanted, invasive intracranial electrodes (whether conventional or S-EEG) are left in place until the patient has experienced several seizures so that electrophysiological data can be obtained to localize the EZ and plan for surgery. The electrodes can be used not only to monitor brain activity but to stimulate given areas of the brain to determine the functions that they control. For instance, if a given portion of the brain is stimulated and a finger moves, then that portion of the brain is critical for that function. By stimulating a number of electrodes, a functional map of the brain can be created to help guide surgery.

When precision counts, as it does when identifying and removing the portion of the brain that is responsible for seizures while ensuring that essential neurologic function is not lost, S-EEG offers neurosurgeons and neurophysiologists at MUSC’s Comprehensive Epilepsy Center an important new tool to achieve excellent outcomes in patients with intractable focal epilepsy.

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Medical University of South Carolina Neurosciences | neuronews

News

Thomas Jhou Honored by Anatomy Society for O utstanding S cientific A chievement in N euroanatomy November 27, 2012 Contact: Melissa Kraft (phone: 301-634-7910 email: mkraft@anatomy.org) Bethesda, Maryland— AAA’s 2013 C.J. Herrick Award in Neuroanatomy goes to Thomas Jhou, who will present an award lecture on “Dopamine and Anti-dopamine Systems: Polar Opposite Roles in Behavior” at the AAA Annual Meeting at EB 2013. The award recognizes Jhou for the significant role he has played in unraveling the complex midbrain and hypothalamic circuitry involved in arousal and motivation, including a noteworthy discovery involving characterization of the rostromedial tegmental nucleus as a critical cell group that interacts with dopaminergic circuitry to convey negative reward signals.

According to nominator Clifford Saper, Jhou is “a remarkable young talent in neuroanatomy and neuroscience, who uses the fundamentals of neuroanatomy to explore the functional significance of brain circuitry.” Saper concludes: “As a former editor of the journal that C. Judson Herrick and his brother (Clarence L. Herrick) started, the Journal of Comparative Neurology, I have seen a lot of work by young investigators, but few deserve so well comparison with C.J. Herrick, who from a very early stage in his career provided one brilliant insight to the nervous system after another.”

Jhou received his B.S. in computer science from MIT and his Ph.D. in neurobiology from Harvard University. After completing postdocs at UC San Francisco, Johns Hopkins University, and the National Institute on Drug Abuse, he joined the Department of Neurosciences at the Medical University of South Carolina as an assistant professor in 2010. In addition to the AAA award, his other honors include a Travel Fellowship for the Winter Conference on Brain Research.

AAA’s Herrick Award is given annually “to recognize young investigators who have made important contributions to the field of comparative neuroanatomy and have demonstrated remarkable promise of future accomplishments.”

The winner was chosen by AAA’s Young Investigator Awards Committee chaired by Andrew J. Ewald (Johns Hopkins Univ. School of Medicine) and included Iain Cheeseman (Whitehead Institute), Julian Guttman (Simon Fraser Univ.), Konrad Hochedlinger (Massachusetts General Hospital), Jason Radley (Univ. of Iowa), Jeremy Reiter (Univ. of California, San Francisco) Peter Reddien (Whitehead Institute for Biomedical Research), and Alexis M. Stranahan (Medical College of Georgia).

The American Association of Anatomists, based in Bethesda, MD, was founded in 1888 for the "advancement of anatomical science." Today, AAA is the professional home for biomedical researchers and educators focusing on anatomical form and function. In addition to being the primary educators of medical students in their first year of medical school, AAA members worldwide work in imaging, cell biology, genetics, molecular development, endocrinology, histology, neuroscience, forensics, microscopy, physical anthropology, and numerous other exciting and developing areas. AAA publishes three journals—The Anatomical Record, Anatomical Sciences Education and Developmental Dynamics—plus a quarterly newsletter. Among its other programs and services, the organization sponsors an Annual Meeting (part of Experimental Biology), runs an extensive awards program, and maintains a website (www.anatomy.org) that offers members and others a variety of tools to enhance their teaching, research, and overall professional development.

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Medical University of South Carolina Neurosciences | neuronews

News

Neuros c ience i n t e n s i ve c a re u n i t move d fo r t em porar y fa c e li ft by

Ashley Barker: Friday, Nov. 2, 2012, the Catalyst

In less than 30 minutes on Tuesday, Oct. 23, seven patients in the neuroscience intensive care unit (NSICU) were moved from the ninth floor to their new home on the eighth floor.

Respiratory therapy coordinator David Crout and registered nurse II Allyson Hiers help move a patient from 9 Center to 8 Center. When 9 Center reopens, there will be 16 NSICU beds.

The move came three hours after the new 8 Center NSICU opened and the 9 Center NSICU closed for a temporary facelift. Construction crews are expected to install new doors, paint the walls and upgrade technology by the end of November. Once completed, the fully equipped 16-bed neuroscience ICU will be operating on the eighth and ninth floors.

"It's been a goal of the service line to add additional ICU beds, just due to the growth of the service line," said June Darby, R.N., administrator of the neuroscience service line.

To commemorate the opening of the unit, a ribbon-cutting ceremony was held. Stuart Smith, vice president for clinical operations and executive director of the medical center, helped cut the ribbon, along with Cheryl Holderfield, R.N., nurse manager of the NSICU, and other members of the unit. NSICU medical director Julio Chalela, M.D., who is a U.S. Army major and brigade surgeon stationed at Camp Bondsteel in Kosovo, communicated via Skype during the ceremony.

"We are excited about the opening of the eighth floor NSICU," he said. "It is the only specialized academic neurosciences intensive care unit in the state of South Carolina and the only place that can provide advanced care for patients with complex neurological injuries."

Neuroscience Service Line administrator June Darby, R.N., shows NSICU medical director Dr. Julio Chalela the new unit. Chalela is currently deployed to Kosovo and Skyped in for the ceremony.

Eight Center was a temporary ICU for surgical trauma, but when that unit moved out it was left empty for quite some time, according to Darby. The NSICU staff — a blend of newly hired and veteran employees — will offer several levels of care in its new facility, ranging from neurosurgery and neuroscience to procedures for tumors, aneurysms and strokes.

In addition to new paint, the NSICU will be able to add an award to its new walls soon. Holderfield was recently named a 2013 American Association of Critical-Care Nurses Circle of Excellence Award recipient.

"I love what I'm doing, and I love MUSC," she said. "Early intervention can make all the difference in the outcome.

We do see a good outcome for a lot of our patients. It's incredible."

Holderfield will be honored at the 2013 AACN National Teaching Institute and Critical Care Exposition in Boston, May 18-23.

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Medical University of South Carolina Neurosciences | neuronews

News

'Magic window' opening wider? Imaging study may redefine conventional treatment time frame for stroke Sep 17, 2012 - MUSC News

(http://academicdepartments.musc.edu/musc/news/health_news/sept_12_stroke.htm)

Practitioners who treat stroke patients now have proof that perfusion imaging can better determine who is and who isn't beyond the "magic window" to restore blood flow to the brain. Lead study author Aquilla Turk, D.O., MUSC Interventional Neuroradiology co-director and neurosciences and radiology professor, described the study as a landmark turn in providing patients with treatments they may not have had otherwise. Currently, the standard of care most providers use as a treatment criterion is the four-hour "magic window."

"This study definitively shows that perfusion imaging as a patient selection criterion for endovascular therapy is a successful evaluation tool, whether patients are presenting at three hours out from their stroke or 11 hours," Turk said. "Broadly speaking, these results could transform our approach to patient selection and ultimately may mean that we will be able to treat significantly more patients and reduce the devastating burden of this disease on individuals and families."

MUSC begin s Re s ve ra t ro l s t u d y f or Al zeim e r ’s d i s e a s e

July 20, 2012 - MUSC Office of Public Relations Press Release (http://www.musc.edu/pr/resveratrol.htm)

Medical University of South Carolina (MUSC) is one of 26 academic institutions nationwide recruiting volunteers for a study on Resveratrol, examining its effects on those with mild to moderate dementia due to Alzheimer’s disease. Geriatric psychiatrist and researcher Jacobo Mintzer, M.D. will be the principal investigator for the MUSC study.

Resveratrol is a compound found in red grapes, red grape juice, red wine, chocolate, tomatoes and peanuts. Preclinical and pilot clinical research studies suggest that resveratrol may prevent diabetes, act as a natural cancer fighter, ward off cardiovascular disease, and prevent memory loss, but there has been no large definitive study of its effects in humans.

The risk of all of these diseases increases with aging. Animal studies suggest that resveratrol may impede molecular mechanisms of aging. Human population studies suggest several health benefits from modest daily consumption of red wine, but the mechanisms of action in the body are unknown.

CT Perf us io n Fi n d i n g s Dr i ve Me c ha n i c a l Th rom bect o my fo r S t ro ke July 20, 2012 - MUSC Neurosciences News and Events

(http://www.muschealth.com/neurosciences/news/CT_Perfusion_Findings_Drive_Mechanical_Thrombectomy_for_Stroke)

Clinical Neurology News recently published an article highlighting a study presented by Jordan Asher Magarik, an MUSC medical student, at the Society of NeuroInterventional Surgery meeting. The study detailed an approach adopted at MUSC's Comprehensive Stroke & Cerebrovascular Center that uses CT perfusion findings to select patients for mechanical thrombectomy resulted in effective, safe treatment of stroke patients beyond the traditional 7- to 8-hour treatment window, results from a single-center study demonstrated.

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Medical University of South Carolina Neurosciences | neuronews

News

M USC Stroke Cent er News

Stroke Conference. MUSC will be well represented at this international conference. Congratulations!

Awards/Recognitions/Congratulations

Community Events

June 30, 2012 – Daniel Lackland, DrPH acknowledged for giving the “Dr. Jose L. Congiano” Magisterial Lecture for the Puerto Rico Nephrology Society, San Juan, Puerto Rico.

September 7, 2012 – Award presented to Robert J. Adams MS, MD, in honor of the “Dr. Cecil L. Parker, Jr. Sickle Cell Disease Distinguished Endowed Lectureship” at the 12th Annual Sickle Cell Regional Conference, University of South Alabama Comprehensive Sickle Cell Center, Mobile, AL. October 12, 2012 –Congratulations to Drs. Robert Adams and Marc Chimowitz Two members of the Department of Neurosciences won two of the most prestigious awards given by the American Heart Association/ American Stroke Association.

Dr. Robert Adams is the winner of the 2013 David G. Sherman Award, which recognizes an "investigator who has made outstanding contributions in the stroke field in their lifetime".

Dr. Marc Chimowitz is the winner of the 2013 William M. Feinberg Award for Excellence in Clinical Stroke, which recognizes an investigator who has "made significant contributions to clinical research in stroke".

November 20, 2012 - The Neuroscience Primary Stroke Center received the American Heart Association /American Stroke Association Gold Plus Award and Honor Roll for Target Stroke. The award was presented at the Hospital Communications meeting on November 20, 2012

by Maggie Bobo.

Holmstedt Passes Boards Congratulations to Dr. Christine A. Holmstedt who passed the boards.

Congratulations to Dr. Feng Dr. Wayne Feng Serves as Member of the Rehabilitation and Recovery Committee of the STROKE Council, American Heart Association/American Stroke Association: July 2012 – June, 2014 Dr. Wayne Feng received "Junior Academic Neurologist Scholarship" from American Neurological Association.

Abstract Selected for AHA/ASA International Stroke Conference Leah Ramos, Cindy Steffen, Sarah Gay and Dr. Chalela’s abstract, “Utilizing a Neuro Intermediate Unit in Caring for Post-Thrombolysis Stroke Patients”, was selected to present at the AHA/ASA International Stroke Conference that will take place in Honolulu in February 2013. Each year, the State-of-the-Science Stroke Nursing Symposium Program Committee selects abstracts that pertain to the goals of the Nursing Symposium to be presented as posters at the International

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July 16, 2012 – Daniel Lackland, DrPH and Andrea Boan, MS, PhD Candidate organized “Strike Out Stroke” - Blood Pressure screening provided by the MUSC Stroke Center faculty, staff and students to over 100 fans attending the RiverDogs baseball game at Joe Riley Stadium, Charleston, SC

Providing education and CME credits to the REACH site hospitals via videoconference presentations:

August 1, 2012 - “Stroke Management for Hospitalists” presented by Edward Jauch, MS, MD, Christine Holmstedt, MD, Jeffery Bodle, MD. Moderated by Robert J. Adams, MS, MD. October 18, 2012 - “Critical Care for Ischemic Stroke” presented by Christos Lazaridis, MD.

Ne u ro s c i e n c e In s t i t u t e (N I ) Meet & Greet Reception

On August 27, 2012, the Neuroscience Institute hosted the annual Meet & Greet Reception at the Wickliffe House to welcome new MUSC PhD students interested in a Neuroscience degree. The reception gave these students the opportunity to interface with other students, postdoctoral scholars, residents, fellows, and faculty from MUSC, as well as neuroscientists from the College of Charleston. This year, labs were invited to present posters to “advertise” what research they are/have been involved in, and to elicit inquiries from the new students. Thirteen labs and over 100 guests participated in this very successful event!

Neuropalooza

Each year, the Neuroscience Institute and the College of Charleston (CofC) partner with the Howard Hughes Medical Institute to host the retreat called Neuropalooza. Initiated in 2009, this annual event includes opportunities to meet and interact with students, postdocs, and faculty from the Medical University of South Carolina (MUSC) and CofC. This year, Neuropalooza was held on October 26, 2012 in the School of Sciences and Mathematics at CofC. The keynote speaker was Dr. Christina Williams, Professor at Duke University. Her talk, “Hippocampal Plasticity and Cognitive Function: Focus on Choline as an Essential Nutrient”, was very well received by the over 100 attendees, as were the talks of several students/postdocs that were given throughout the day.

Students and postdocs presented 38 posters to showcase their research and discuss their work with interested faculty and staff in a relaxed environment. It was a great time for MUSC labs to meet CofC students who might be interested in research projects...and a great way to see the breadth of neuroscience research across the Charleston community!

Medical University of South Carolina Neurosciences | neuronews

News

Resi dency Program Updat e Resident News

Neurology Residents Jeff Bodel, Jay Madey and Jill and Karen Sequaria will be attentending the American Academy of neurology meeting this April.

Olivia Burch Receives Dual TAGME Certification

Congratulations to Olivia Burch. She has successfully completed her TAGME certification in Neurological Surgery and Neurology. This is an exam given by The National Board for Certification for Training Administrators of Graduate Medical Education Programs (TAGME) for program coordinators. She is currently the only coordinator university wide that is dual certified in Neurology and Neurological Surgery.

Kalra honored with FACP

Congratulations to Amandeep Kalra, MD, FACP. He was recently honored as a Fellow of the American College of Physicians. Fellowship in the College is an honor. Being an FACP is a distinction earned from colleagues who recognize your accomplishments and achievements over and above the practice of medicine. The most important considerations for ACP Fellowship are excellence and contributions made to both medicine and to the broader community in which the internist lives and practices.

O ther New s Article in Clinical Advisor

Congratulations to Carrie Smith, PA-C, and David Stickler, MD! Their review on MG is the cover article in this month's Clinical Advisor, and is also being used as a CME opportunity.

New RO1 grant to Dr. See:

"Corticostriatal Neuroplasticity and Cognition in Methamphetamine Addiction" RO1 DA033049 – NIDA, 9/15/12–6/30/17 ($225,000/year direct costs)

Reichel & Gipson Receive Award

Dr. Carmela Reichel and Dr. Cassandra Gipson both received the American College of Neuropsychopharmacology (ACNP) Young Investigator Memorial Travel Award for 2012.

Cheryl Holderfield Wins Nursing Award

Cheryl Holderfield has been selected to receive the 2013 American Association of Critical- Care Nurses Circle of Excellence Award, which recognizes and showcases the excellent outcomes of individuals in caring for high acuity and critically ill patients and their families. With this award, Cheryl will be welcomed into the AACN Circle of Excellence Society. As a 2013 AACN Circle of Excellence Award recipient she will be honored at the 2013 AACN National Teaching Institute and Critical Care Exposition in Boston, May 18 - May 23. She will receive an award plaque, a $1,000 honorarium and one complimentary NTI main conference registration.

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Cave receives NSL Employee Excellence Award

Kelly Cave was presented the Neuroscience Service Line Employee Excellence Award in September 2012 at the NSL Manager’s meeting.

Some of the comments on the nomination forms include: “She continues to be a silent super star for all of us! She is always there to help and never complains about anything even though you can clearly tell that she is overloaded at times. She never says that she is too busy to help. She is a great resource when I need to find information or need help with systems like (LDI, Kronos or Success Factors). She is a true super user to all our systems. I for one, am very grateful to have her on our team and am thankful for all the support and help that she gives”.

“She always has a positive attitude and never says that she “can’t” do something or complains. Kelly steps up no matter what the situation is to get things done – and done right”. Thank you Kelly for all you do for the NSL!

Bruce Frankel featured in the Post and Courier

Dr. Bruce Frankel discusses Fungal meningitis in the Post and Courier article, Fungal meningitis cases soar nationally; none reported here. To read the article please visit the below link: http://www.postandcourier.com/article/20121009/ PC16/121009235/1165/fungal-meningitis-cases-soar-nationally-nonereported-here

East Cooper Grand Opening

Drs. Patel and Frankel, Gayle Wadford and Deb Adams all represented Neurosciences at the East Cooper Grand Opening.

Institute for Applied Neurosciences (IAN) a Reality

After 2 years of discussions and legal planning as well as seeking donor funding and final approvals the Institute of Applied Neurosciences (IAN) is now a reality. This has been made possible by the group effort of several Neurosciences faculty members, including Drs Patel and Frankel, along with external consultants, the Foundation for Research Development (FRD), major donors, and President Greenberg. The IAN is a 501c3 entity affiliated with MUSC which will serve the Department of Neurosciences as a new technology incubator.

Bruce Frankel, M.D. has accepted the offer to serve as the Medical Director of IAN, effective November 1, 2012 and has also been appointed as Vice Chair for Research and Development for Neurosurgery and Neurosciences.

"Bruce brings a significant experience with patents and product development and we all believe he will be a superb leader and mentor in this role. " - Dr. Sunil Patel Mark Semler is the COO/CTO of IAN. Mark brings with him an extensive background of experience not only as a mechanical engineer but most recently as a VP of Research and Development in the industry. Mark has an invaluable understanding of product design, marketing, intellectual property, and regulatory issues. He has vast experience over a wide variety of medical devices, making him an incredible asset to IAN. Mark and Dr. Frankel have 15+ patents issued and/or pending, and are eager to assist others in developing their visions and concepts.

Medical University of South Carolina Neurosciences | neuronews

Publications

Fea tured Pu bl ic at ions Reichel CM, See RE (2012) Attenuation of methamphetamineseeking after chronic modafinil administration in rats. International Journal of Neuropsychopharmacology; 15(7):919-929.

Zhou L, Aston-Jones G, Smith RJ, Do PH, See RE (2012) Repeated orexin 1 receptor antagonism effects on cocaine seeking in rats.

Neuropharmacology; 63(7):1201-1207.

Buffalari DM, Baldwin CK, See RE (2012) Treatment of cocaine withdrawal anxiety with guanfacine: relationships to cocaine intake and reinstatement of cocaine-seeking in rats. Psychopharmacology; 223:179–190.

Reichel CM, Chan C, Ghee SM, See RE (2012) Escalation of methamphetamine self-administration in male and female rats: Cognitive and motivational consequences. Psychopharmacology; 223:371–380.

Collins, H. R., Zhu, X., Bhatt, R. S., Clark, J. D., & Joseph, J. E. (in press). Process- and domain-specificity in regions engaged for face processing: an fMRI study of perceptual differentiation. Journal of Cognitive Neuroscience.

Joseph, J. E., Swearingen, J., Clark, J. D., Benca, C. E., Collins, H. R., Corbly, C., Gathers, A. & Bhatt, R. S. (2012). The changing landscape of functional brain networks for face processing in typical development. NeuroImage, 63, 1223-1236.

Shen H, Kalivas PW. Reduced LTP and LTD in prefrontal cortex synapses in the nucleus accumbens after heroin self-administration. Int J Neuropsychopharmacol. 2012 Oct 31:1-3. [Epub ahead of print]

Pu blication Hi g h li g h t :

Relapse risk after discontinuation of risperidone in Alzheimer's disease.

N Engl J Med. 2012 Oct 18;367(16):1497-507. doi: 10.1056/ NEJMoa1114058.

Devanand DP, Mintzer J, Schultz SK, Andrews HF, Sultzer DL, de la Pena D, Gupta S, Colon S, Schimming C, Pelton GH, Levin B.

BACKGROUND: Among patients with Alzheimer's disease who have had a response to antipsychotic medication for psychosis or agitation-aggression, the risk of a recurrence of symptoms after discontinuation of the medication has not been established.

CONCLUSIONS: In patients with Alzheimer's disease who had psychosis or agitation that had responded to risperidone therapy for 4 to 8 months, discontinuation of risperidone was associated with an increased risk of relapse.

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Need medical illustrations to accompany your upcoming publication?

Visit www.MUSC.edu/neurosciences/resources or email vought@musc.edu Scofield MD, Korutla L, Jackson TG, Kalivas PW, Mackler SA. Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral Sclerosis. Neuroscience. 2012 Sep 25;227C:44-54. doi: 10.1016/j.neuroscience.2012.09.043. [Epub ahead of print] Mahler SV, Hensley-Simon M, Tahsili-Fahadan P, Lalumiere RT, Thomas C, Fallon RV, Kalivas PW, Aston-Jones G. Modafinil attenuates reinstatement of cocaine seeking: role for cystineglutamate exchange and metabotropic glutamate receptors. Addict Biol. 2012 Sep 27. doi: 10.1111/j.1369-1600.2012.00506.x. [Epub ahead of print] Trantham-Davidson H, LaLumiere RT, Reissner KJ, Kalivas PW, Knackstedt LA. Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training. J Neurosci. 2012 Sep 5;32(36):12406-10. doi: 10.1523/JNEUROSCI.1976-12.2012.

Esparza MA, Bollati F, Garcia-Keller C, Virgolini MB, Lopez LM, Brusco A, Shen HW, Kalivas PW, Cancela LM. Stress-induced sensitization to cocaine: actin cytoskeleton remodeling within mesocorticolimbic nuclei. Eur J Neurosci. 2012 Oct;36(8):3103-17. doi: 10.1111/j.1460-9568.2012.08239.x. Epub 2012 Aug 12.

PMID: 22882295 [PubMed - in process] Collins, H. R., Corbly, C. R., Liu, X., Kelly, T. H., Lynam, D. L. & Joseph, J. E. (in press). Too little, too late or too much, too early? Differential hemodynamics of response inhibition in high and low sensation seekers. Brain Research.

Upshaw JE, Gosserand JK, Williams N, Edwards JC. Sports-related concussions. Pediatric emergency care. 2012;28(9):926-932.

Williams N, Sas A, Madey J, Bodle J, Scovel L, Edwards J. High school coaches perceptions of physicians' role in the assessment and management of sports-related concussive injury. Frontiers in Sports Neurology. 2012;3:130-130.

Wuwei Feng, Shunaiber Tauhid, Sweta Goel, Evgeny Sidorov, Magdy Selim. Hyperglycemia and Outcome in Intracerebral Hemorrhage: From Bedside to Bench - More Pre-clinical Study is Needed. Stroke Translational Research. 2012; 3 (Suppl 1): S113-S118

Medical University of South Carolina Neurosciences | neuronews

Publications

Ana C. Pereira, Andrew Schomer, Wuwei Feng, Umer Najib, WooKyoung Yoo, Marine Vernet, Michael P. Alexander, Louis R. Caplan, Alvaro Pascual-Leone. The anterior Disconnection Syndrome Revisited Using Modern Technologies. (July 13 2012 Epub, Neurology) Wuwei Feng, Evgeny Sidov, Kara Smith, Magdy Selim. Recurrent Lobar Intracerebral Hemorrhage in Tangier Disease. Journal of Stroke and Cerebrovascular Disease, Nov 19, 2011.

Turk AS, Nyberg EM, Chaudry MI, Turner RD, Magarik JA, Nicholas JS, Holmstedt CA, Chalela JA, Hays A, Lazaridis C, Chimowitz MI, Turan TN, Adams RJ, Jauch EC. Utilization of CT perfusion patient selection for mechanical thrombectomy irrespective of time: a comparison of functional outcomes and complications. 2012 Aug 30.

[Epub ahead of print]J Neurointerv Surg.

Madey J, Lehman RK, Chaudry I, Vaillancourt SL. Teaching NeuroImages: Atypical Wyburn-Mason syndrome. Neurology. 2012 Sep 4;79(10):e84. doi: 10.1212/WNL.0b013e318268460f. No abstract available. PMID: 22946119 [PubMed - in process] Williams N, Sas A, Madey J, Bodle J, Scovel L, Edwards J. High school coaches perceptions of physicians' role in the assessment and management of sports-related concussive injury. Front Neurol.

2012;3:130. doi: 10.3389/fneur.2012.00130. Epub 2012 Oct 5.

Krishna V, Lazaridis C, Ellegala D, Glazier S, Kindy M, Spampinato M, Chalela JA. Spinal cord infarction associated with subarachnoid hemorrhage. Clin Neurol Neurosurg. 2012 Sep;114(7):1030-2. Epub 2012 Mar 2. No abstract available. PMID: 22386902 [PubMed - in process] Morgan SL, Krishna V, Varma AK. Cervical pseudomeningocele as a cause of neurological decline after posterior cervical spine surgery.

Neurol India. 2012 Mar-Apr;60(2):256-7. No abstract available.

V Krishna, K Walsh, RD Turner, J Chalela, A Turk, SJ Patel. Impact of integrated cerebrovascular program on outcomes in patients with intracranial aneurysms. Journal of NeuroInterventional Surgery Frankel BM, Krishna V. Meta-analysis: vertebroplasty for vertebral compression fracture ineffective in improving pain and function.

Evid Based Med. 2012 Oct;17(5):142-3. Epub 2011 Nov 1. No abstract available. PMID: 22044795 [PubMed - in process] Lazaridis C, DeSantis SM, McLawhorn M, Krishna V. Liberation of neurosurgical patients from mechanical ventilation and tracheostomy in neurocritical care. J Crit Care. 2012 Aug;27(4):417.e1-8. Epub 2011 Oct 26. PMID: 22033050 [PubMed - in process] Haar CP, Hebbar P, Wallace GC 4th, Das A, Vandergrift WA 3rd, Smith JA, Giglio P, Patel SJ, Ray SK, Banik NL. Drug resistance in glioblastoma: a mini review. Neurochem Res. 2012 Jun;37(6):1192-200.

Epub 2012 Jan 10. Review.

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Giglio P, Dhamne M, Hess KR, Gilbert MR, Groves MD, Levin VA, Kang SL, Ictech SE, Liu V, Colman H, Conrad CA, Loghin M, de Groot J, Yung WK, Puduvalli VK. Phase 2 trial of irinotecan and thalidomide in adults with recurrent anaplastic glioma. Cancer. 2012 Jul 15;118(14):3599-606. doi: 10.1002/cncr.26663. Epub 2011 Nov 15.

Das A, Wallace GC 4th, Holmes C, McDowell ML, Smith JA, Marshall JD, Bonilha L, Edwards JC, Glazier SS, Ray SK, Banik NL. Hippocampal tissue of patients with refractory temporal lobe epilepsy is associated with astrocyte activation, inflammation, and altered expression of channels and receptors. Neuroscience. 2012 Sep 18;220:237-46. Epub 2012 Jun 12.

Mooney JF, Glazier SS, Barfield WR. Concurrent orthopedic and neurosurgical procedures in pediatric patients with spinal deformity. J Pediatr Orthop B. 2012 Nov;21(6):602-5. doi: 10.1097/ BPB.0b013e328357ea38.

Bateman LM, Begley CE, Ben-Menachem E, Berg AT, Berkovic SF, Cascino GD, Drazkowski J, Edwards JC, Engel J Jr, French JA, Gilliam FD, Hoerth MT, Jehi LE, Kanner AM, Krauss GL, Labiner DM, Loddenkemper T, Luders HO, McKhann GM 2nd, McLachlan R, Modi A, Pennell PB, Shafer PO, Sirven JI, Stern JM, Szaflarski JP, Theodore WH. Overcoming barriers to successful epilepsy management.

Epilepsy Curr. 2012 Jul;12(4):158-60. No abstract available.

Towfighi A, Markovic D, Ovbiagele B. Utility of framingham coronary heart disease risk score for predicting cardiac risk after stroke. Stroke.

2012 Nov;43(11):2942-7. doi: 10.1161/STROKEAHA.112.668319. Epub 2012 Sep 4.

Pu b l i c ati o n Hi g h l i g h t: Risk of intracranial hemorrhage with protease-activated receptor-1 antagonists.

Lee M, Saver JL, Hong KS, Wu HC, Ovbiagele B. Stroke. 2012 Dec;43(12):3189-95. doi: 10.1161 STROKEAHA.112.670604.

Epub 2012 Nov 15.

MUSC's new Chair of Neurology, Bruce Ovbiagele, M.D. recently published the results of a study on PAR-1 antagonists in the journal Stroke. A Reuter's interview for Modern Medicine with Dr. Ovbiagele discussing the results is available online and you can access the journal article on the Stroke Journal website. http://stroke.ahajournals.org/content/43/12/3189.abstract http://www.modernmedicine.com/modernmedicine/ Modern+Medicine+Now/PAR-1-antagonists-up-risk-of-hemorrhagic-stroke/ ArticleNewsFeed/Article/detail/798046?contextCategoryId=40130

Medical University of South Carolina Neurosciences | neuronews

clinical Trials

Cl i ni ca l Tri a ls Th e Following Ne uro sc i e nc e s Cli ni c al Tr i al s are Ac ti ve l y En ro l l i n g S u b j e c ts (Alzheimer's, Spine, Movement Disorders, Epilepsy, Neuro-Oncology)

A lzheimer's Clinical Trials Title

Sponsor

Principal Investigator

Study Coordinator

Contact/ Phone/Email

ALZHEIMER'S DISEASE NEUROIMAGING INITIATIVE - 2 To examine how brain imaging technology can be used with other tests to measure the progression of Mild Cognitive Impairment (MCI) and early Alzheimer’s Disease.

National Institute on Aging

Jacobo Mintzer M.D., MBA David Bachman M.D.

Arthur Williams

Marie Corbin 843-740-1592 ext. 14 corbinm@musc.edu

AVP-923 Avanir To assess the efficacy, safety, and tolerability of Pharmaceuticals, AVP-923 (dextromethorphan/quinidine) for the Inc. treatment of symptoms of agitation in patients with Alzheimer's disease.

Jacobo Mintzer M.D., MBA David Bachman M.D.

Joanne Rose, R.N.

Marie Corbin 843-740-1592 ext. 14 corbinm@musc.edu

CITAD To study the effectiveness of citalopram for reducing agitation in people with Alzheimer’s Disease.

National Institute of Health

Jacobo Mintzer M.D., MBA David Bachman M.D.

Nicholas Gregory

Marie Corbin 843-740-1592 ext. 14 corbinm@musc.edu

RES To evaluate the impact on biomarkers of resveratrol treatment in patients with mild to moderate Alzheimer’s Disease.

Alzheimer's Disease Cooperative Study and National Institute on Aging

Jacobo Mintzer M.D., MBA David Bachman M.D.

Nicholas Gregory

Marie Corbin 843-740-1592 ext. 14 corbinm@musc.edu

MAYFLOWER ROAD Evaluate the efficacy of a 12-month treatment of RO4602522 versus placebo added to background therapy of donepezil or rivastigmine in patients with moderate severity Alzheimer’s

Roche

Jacobo Mintzer M.D., MBA David Bachman M.D.

Nicholas Gregory

Marie Corbin 843-740-1592 ext. 14 corbinm@musc.edu

Movement Disorders Clinical Trials

To find out more about clinical trials at MUSC Sponsor Principal Investigator Study Cvisit: oordinator

Title

Parkinson’s Disease Neuroprotection Clinical Trial Center - FS Zone Supplemental Study (FS Zone) Atomoxetine Treatment for Cognitive Impairment in Parkinson's Disease (ATM-Cog).

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NIH/NINDSwww.MUSC.edu/TRU Vanessa Hinson, M.D., Ph.D.

Michael J. Fox Foundation

Vanessa Hinson, M.D., Ph.D.

Contact/Phone/Email

Jennifer Zimmerman, RN

Jennifer Zimmerman, RN 843-792-9115 zimmerj@musc.edu

Jennifer Zimmerman, RN

Jennifer Zimmerman, RN 843-792-9115 zimmerj@musc.edu

Medical University of South Carolina Neurosciences | neuronews

clinical Trials

A Pilot Study of Atomoxetine for Freezing of Gait in Parkinson’s Disease.

MUSC Department of Neurosciences

Gonzalo Revuelta, D.O.

Amy DeLambo, ACNP

Amy DeLambo, ACNP 843-792-7262 delambo@musc.edu

Cervical Dystonia Patients with Merz.

Merz Pharmaceuticals, LLC.

Christina Vaughan, M.D.

Jennifer Zimmerman, RN

Jennifer Zimmerman, RN 843-792-9115 zimmerj@musc.edu

Creatine Safety, Tolerability, and Efficacy in Huntington's Disease: CREST-E (Crest-E)

Massachusetes General Hospital

Gonzalo Revuelta, D.O.

Amy DeLambo, ACNP

Amy DeLambo, ACNP 843-792-7262 delambo@musc.edu

Title

Sponsor

Principal Investigator

Study Coordinator

Contact Phone/Email

A Double-blind, Randomized, Placebocontrolled, Multicenter, Parallel-group Study with an Open-label Extension Phase to Evaluate the Efficacy and Safety of Adjunctive Perampanel in Primary Generalized TonicClonic Seizures

Eisai

Jonathan Halford, M.D.

Ashley Gantt

Ashley Gantt 843-792-7118 gantt@musc.edu

This study will evaluate the efficacy and safety of brivaracetam at doses of 100 and 200 mg/day compared to placebo as adjunctive treatment in adult focal epilepsy subjects with partial onset seizures not fully controlled despite current treatment with 1 or 2 concomitant antiepileptic drugs.

UCB, Inc.

Jonathan Halford, M.D.

Ashley Gantt

Ashley Gantt 843-792-7118 gantt@musc.edu

A prospective, open-label study of the structure and function of the retina in adult patients with refractory complex partial seizures treated with vigabatrin (SabrilÂŽ) (Lundbeck Vision)

Lundbeck, Inc

Ekrem Kutluay, M.D.

Ashley Gantt

Ashley Gantt 843-792-7118 gantt@musc.edu

Epilepsy Clinical Trials

Clinical trials are the primary way breakthroughs in treating diseases are made.

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Medical University of South Carolina Neurosciences | neuronews

clinical Trials

Utility of Intravenous Lacosamide compared with fosphenytoin in the treatment of patients with frequent nonconvulsive seizures (TRENdS)

Duke Clinical Research Institute

Brain surgery is an effective treatment for National Institute people who suffer from intractable epilepsy, of Health and the most common type of epilepsy surgery is removal of the anterior temporal lobe (ATL).

Removal of the left ATL, however, causes cognitive side effects, particularly partial loss of language and memory ability, in about half of these patients. The goal of this project is to identify factors that determine which patients will experience these side effects so that they can be avoided or minimized. Many epilepsy centers have begun to use functional magnetic resonance imaging (fMRI) to “map” language and memory zones prior to surgery, but the meaning of these maps is unclear. Most of the fMRI methods in current use are not reliable at detecting functional areas in the ATL. More fundamentally, it is unknown whether areas judged to be “active” by fMRI are critically necessary for normal function.

Roughly 232 patients nationwide who undergo left ATL removal will be studied before and after surgery, using neuropsychological tests, standard MRI, a well-validated fMRI measure of language dominance, and a novel fMRI method that is very sensitive at detecting activation responses in the ATL. The study will test the hypothesis that cognitive outcome after left ATL surgery depends on both the degree to which ATL semantic networks are damaged during surgery and on the degree to which language functions are lateralized to the left hemisphere, as the latter indicates how tightly the left ATL semantic system is coupled to other language systems.

This research will provide the first definitive information about the validity of using fMRI for surgical planning, will provide a new model for the conduct of such validation studies, and will help bring about standardization of fMRI protocols for this application.

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Jonathan Halford, M.D.

Ashley Gantt

Ashley Gantt 843-792-7118 gantt@musc.edu

Truman Brown, M.D.

Sheri Davis

Sheri Davis 843-792-2845 davshe@musc.edu

Medical University of South Carolina Neurosciences | neuronews

clinical Trials

S troke: Title

Sponsor

Principal Investigator

Study Coordinator

Contact Phone/Email

The purpose of this study is to assess the changes in language processing of patients with chronic, post-stroke aphasia following the application of brain stimulation. The brain stimulation we administer is called transcranial direct current stimulation (tDCS). It involves passing a weak electrical current through the brain between two electrodes in the form of damp sponges. One sponge will be placed over a specified area on the damaged left hemisphere, while the other sponge will be placed on the right scalp. Computercontrolled speech-language treatment will be administered during the application of tDCS.

National Institute of Health

David Bachman, M.D.

Sheri Davis

Sheri Davis 843-792-2845 davshe@musc.edu

Neuro-Oncology Clinical Trials Title

Sponsor

Principal Investigator

Study Coordinator

Contact Phone/Email

BTTC 11-01 Randomized, Double-Blind Placebo-Controlled Trial of Lacosamide for Seizure Prophylaxis in Patients with HighGrade Gliomas

Clinical Trials Office (Hollings Cancer Center)/ BTTC (Brain Tumor Trials Collaborative)

Pierre Giglio, M.D. Tel: 843-792-6592

Michele DeCandio, RN

Michele DeCandio, RN Tel: 843-792-9016 E-mail: decandio@musc.edu

Diffusion: Protocol # 100-202 Open-Label Phase I/2 (Safety Lead-In) Study of Trans Sodium Crocetinate (TSC) with Concomitant Treatment of Fractionated Radiation Therapy and Temozolomide in Newly Diagnosed Glioblastoma (GBM) Patients to Evaluate Safety and Efficacy

Translational Research Unit (TRU)/ Diffusion Pharmaceuticals LLC

Pierre Giglio, M.D. Tel: 843-792-6592

Michele DeCandio, RN

Michele DeCandio, RN Tel: 843-792-9016 E-mail: decandio@musc.edu

Protocol CDX110-04: “An International, Randomized, Double-Blind, Controlled Study of Rindopepimut/GM-CSF with Adjuvant Temozolomide in Patients with Newly Diagnosed, Surgically Resected, EGFRvIIIpositive Glioblastoma (The “Act IV” Study)

Translational Research Unit (Neurosciences)/ Celldex Therapeutics

Bruce Frankel, M.D. Tel: 843-792-1470

Michele DeCandio, RN

Michele DeCandio, RN Tel: 843-792-9016 E-mail: decandio@musc.edu

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Medical University of South Carolina Neurosciences | neuronews

clinical Trials

A Phase II Clinical Trial Evaluating DCVax®Brain, Autologous Dendritic Cells Pulsed with Tumor Lysate Antigen for the Treatment of Glioblastoma Multiforme

Translational Research Unit (Neurosciences)/ Northwest Biotherapeutics, Inc.

Pierre Giglio, M.D. Tel: 843-792-6592

Michele DeCandio, RN

Michele DeCandio, RN Tel: 843-792-9016 E-mail: decandio@musc.edu

Glioblastoma, Recurrent: CTO: 101482 RTOG 0929: Randomized Phase I/ II Study OF ABT-888 in Combination with Temozolomide in Recurrent (Temozolomide Resistant) Glioblastoma

Clinical Trials Office (Hollings Cancer Center)/ RTOG 0929

Pierre Giglio, M.D. Tel: 843-792-6592

John Keller

John Keller Tel: 843-792-1286 E-mail: kellej@musc.edu

Glioblastoma, Recurrent: A Phase I/II Study of Intraventricular Depocyt (Orphan Drug Designation 06-2348) in Patients with Recurrent Glioblastoma

Translational ReBruce Frankel, M.D. search Unit (TRU) Tel: 843-792-1470

Michele DeCandio, RN

Michele DeCandio, RN Tel: 843-792-9016 E-mail: decandio@musc.edu

Anaplastic Glioma, Adjuvant (1): CTO: 101450 RTOG EORTC 0834/26053 22054, “Phase III Trial on concurrent and adjuvant temozolomide chemotherapy in Non-1p/19q deleted anaplastic glioma.”

Clinical Trials Office (Hollings Cancer Center)/ RTOG 0834

Pierre Giglio, M.D. Tel: 843-792-6592

John Keller

John Keller Tel: 843-792-1286 E-mail: kellej@musc.edu

*Anaplastic Glioma, Adjuvant (2): CTO: 101449 Phase III Intergroup Study of Radiotherapy versus Temozolomide Alone versus Radiotherapy with Concomitant and Adjuvant Temozolomide for Patients with Ip/ 19q Codeleted Anaplastic Glioma’

Clinical Trials Office (Hollings Cancer Center)/ NCCTG N0577

Pierre Giglio, M.D. Tel: 843-792-6592

John Keller

John Keller Tel: 843-792-1286 E-mail: kellej@musc.edu

*Active but not recruiting.

D C Vax ® C l i n i c al Tr i al “A Phase II Clinical Trial Evaluating DCVax® Brain, Autologous dendritic Cells Pulsed with Tumor lysate Antigen for the Treatment of Glioblastoma multiforme” proposes to study the potential efficacy of a “vaccine” developed by exposing immune cells obtained f rom patients with glioblastoma with a lysate from the tumor obtained at surger y for tumor resection. ~ P ierre Giglio, M.D.

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A stylized illustration of a t-cell being activated by a dendritic cell. Image created by E. C. Vought.

For more information on this trial call 843-792-9016.

Medical University of South Carolina Neurosciences | neuronews

Low Grade Glioma, Progressive: CTO: 101399 ECOG E3F05, “Phase III Study of Radiation Therapy With or Without Temozolomide for Symptomatic or Progressive Low-Grade Gliomas.”

Clinical Trials Office (Hollings Cancer Center)/ECOG E3F05

Pierre Giglio, M.D. Tel: 843-792-6592

John Keller

John Keller Tel: 843-792-1286 E-mail: kellej@musc.edu

Imaging Biomarkers of Tissue Microstructure and Vasculature as Predictors of Glioblastoma Multiforme Response to Treatment with Bevacizumab for Progressive Disease

Clinical Trials Office (Hollings Cancer Center)/

Pierre Giglio, M.D. Tel: 843-792-6592

John Keller

John Keller Tel: 843-792-1286 E-mail: kellej@musc.edu

“The Correlation between the Genetic & Neuroimaging Signatures in Newly diagnosed Glioblastoma”

Translational Research Unit (Neurosciences)/ Northwest Biotherapeutics, Inc.

Pierre Giglio, M.D. Tel: 843-792-6592

Michele DeCandio, RN

Michele DeCandio, RN Tel: 843-792-9016 E-mail: decandio@musc.edu

The Efficacy of PF-02341066 (Crizotinib), a Dual ALK/c-Met Inhibitor in Inhibiting Growth of Glioblastoma

Translational Research Unit (TRU)/Pfizer

Pierre Giglio, M.D. Tel: 843-792-6592 Arabinda Das, Ph.D. E-mail: dasa@musc.edu

Michele DeCandio, RN

Michele DeCandio, RN Tel: 843-792-9016 E-mail: decandio@musc.edu

The Effect of Garlic Compounds on Fresh Human Glioma Biopsies: CTO: 101378

Translational Research Unit (Neurosciences)

Arabinda Das, Ph.D. E-mail: dasa@musc.edu

Michele DeCandio, RN

Michele DeCandio, RN Tel: 843-792-9016 E-mail: decandio@musc.edu

They

Joseph Helpern, Ph.D. E-mail: helpern@musc.edu

shed light on new ways to detect, diagnose and reduce risk of disease.

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Medical University of South Carolina Neurosciences | neuronews

Employee Update & Social News

Wel c ome New Employee s Davis, Jalietta Gardner, Holly (FNP) Schmall, Ashleigh (Fiscal Technician II) Semler, Mark Barrett, Diana (Admin Asst) Bonilha, Leo (Assistant Professor) Shih, Andy (Assistant Professor) Summers, Philipp (Grad Asst) Thadore, Nakul (Lab Spec) Gotshall, Alexandra (Prog Asst) Schultz, Gabrielle (Prog Coord I) Zhu, Tianyu (Res Spec I) DiBartolo, Michelle (Res Spec I) Dixon-Mah, Yaenette N (Res Spec I) Columbo, Laura (Res Spec II) Brown, Kelsey (RS I) Schutt, Steven (RS I-part time) McGonigal, Justin (RSI)

G o o d bye a nd G o o d Luck Smyre, Karen (Administrative Asst.)

Woods, Marci (APRN) Heissenbuttle, Carol (Admin Coord) Parker, Brenda (Admin Mgr) Jayanthi, Lankupalle (Assistant Professor) Budney, Rose (Fiscal Tech II) Matthews, Alex (Grad Asst) Shen, Zhiming (Postdoc) Mannangatti, Pad (Postdoc) Ramamoorthy, Sammanda (Professor ) Wang, Chiang (Res Asst Prof) Hensley-Simon, Megan (RS II) Barnwell, Eliza (RSI) Saggu, Shalini (Staff Scientist I)

starting from top (going clockwise)

Neurosciences Heart Walk team with Jack's Cosmic Dogs · Neurosciences Heart Walk team with Jack's Cosmic Dogs · Beth Whitaker's new baby boy Myles Foster Whitaker, born Nov. 14th at 11:25 pm weighing 7 ibs 3 oz · One of MUSC's Heart Walk Teams, the BraveHearts, at the event

17

Medical University of South Carolina Neurosciences | neuronews

Medical University of South Carolina

Neurosciences

"Like" us on Facebook

Visit our page to view upcoming events & news, meet our team, learn about current treatments

Neuroscience Institute Poster Printing $60 for posters printed on 36 inch paper and $75 for posters printed on 42 inch paper. www.MUSC.edu/neurosciences/resources

Neuros c i e n c e s Res ource s Neurosciences offers a variety of resources for it's faculty and staff including; medical illustration, animation, graphic design & web design: Free of charge!

and more...

www.MUSC.edu/neurosciences/resources

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Medical University of South Carolina Neurosciences | neuronews

The Medical UniversiTy of soUTh carolina Proudly presented by the college of Medicine student council a n d t h e Medical student alumni council

7pm until 11pm

heavy hors d’oeuvres and cash bar serving beer and wine : black tie optional l i v e m u s i c b y P e r m a n e n t Va c a t i o n

silent auction begins at 7pm tickets $50 per person

the twenty-sixth annual

Alumni may purchase 2 tickets for $45 a piece Each additional ticket is $50 Students may purchase 2 tickets for $20 a piece Each additional ticket is $50

february

16

2013 memminger auditorium

available at the College of Medicine Dean’s Office beginning December 12th

792-5862 for more information

limited number

of tickets

will be sold f or t h i s event!

silent auction to benefit crisis ministries : operation home the charleston area children’s garden project (cacgp) lowcountry pregnancy center : junior girls day out community project : cares clinic crisis ministries wednesday night clinic fight for sight

Hockey Heroes for Epilepsy Friday, January 18, 2013 7:05 pm, North Charleston Coliseum Join MUSC, the South Carolina Advocates for Epilepsy (SAFE) and the South Carolina Stingrays for Epilepsy Awareness Night. Bring your family and friends out for a night of great hockey and fun. A silent auction will help raise money for REEF (Research and Education in Epilepsy Fund) at MUSC and SAFE.

VS. To purchase tickets call 843-744-2248

(ask for Mary Ann)

Tickets will also be sold on Jan. 2 & 16, 11 am to 2 pm, next to MUSC’s Main Hospital Cafeteria. visit www.scepilepsy.org

Thank you for your contributions.

For questions, comments or to make a submission please contact: Emma C. Vought at vought@musc.edu

www.MUSC.edu/neurosciences Š 2012 Medical University of South Carolina. All rights reserved.

Medical University of South Carolina Neurosciences