OutramNow July/August 09

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July/August 2009 ❙

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Patients. At the Heart of All We Do. A bi-monthly publication of Singapore General Hospital, the nation’s flagship hospital within the SingHealth group

Issue 15

July/August 2009 MICA (P) 008/01/2009

I N S I D E Looking for a Diabetes Patient Champion. Pg

9

Commit a crime while sleeping? Pg

12-13

77-year-old springs back to health after novel heart valve procedure. Pg

16

Trumping the odds

Singapore General Hospital (SGH) and its sister institution,the National Heart Centre Singapore (NHCS), recently performed the first combined heart and liver transplant in Asia. The medical teams involved in the rare procedure talk about the surgery and planning to overcome the many risks associated with this procedure. By Yong Yung Shin

When Mr Lau Chin Kwee was diagnosed with Familial Amyloid Polyneuropathy (FAP) in 2005, it might as well have been a death sentence. The rare genetic condition,which disrupts the functions of the nervous system, heart, gut and kidney through a mutant protein produced in the liver, has no known cure - and the only solution was to replace the liver. In September 2006, the 58-year-old retired pastor was referred to SGH’s Liver Transplant Service for a possible liver transplant. His heart, found to have been affected by the disease, would also need to be replaced. In November 2008, Mr Lau was put on the waiting list for a combined heart and liver transplant. The surgery had posed a dilemma for

What we learnt was to not shy away from doing something just because we had never done it before, but to reason through all options carefully with the patient’s interests at heart.

said Associate Professor Tan Chee Kiat, Director of the Liver Transplant Programme at SGH

doctors: Singapore doctors had never performed the complicated procedure. As of 30 June 2008, only 17 heart and liver transplants had been successfully performed worldwide on patients with Mr Lau’s condition - and the mortality rate for such procedures was estimated at 30%. “While it is usually not advisable to perform transplantation surgeries where the mortality rate is above 5%, we kept in mind that without the operation, it would have been certain death for him,” said Associate Professor Tan Chee Kiat, Director of SGH’s Liver Transplant Service and Senior Consultant of SGH’s

Department of Gastroenerology & Hapatology. Doctors also worried if Mr Lau, extremely malnourished and weakened by prolonged diarrhoea after the abnormal protein began to affect his gut, would be able to cope with the stress of a double organ transplant. Sequence of procedures crucial “Surgically, there were not too many technical challenges because both the heart and liver teams performed the same procedures as they would in a usual heart or liver transplant,” said Dr Tan Yu Meng, Surgical Director of the Liver Transplant Programme and

Our last OutramNow – we return with a bigger, better paper later this year Two and a half years. Fifteen issues. And a readership that keeps rising. When we embarked on our journey at the beginning of 2007 to publish Singapore’s only patient newspaper, we didn’t envisage that OutramNow would grow into the publication that it is today – a widely read, respected paper filled with information about SGH and its sister institutions, the latest services and treatments, illnesses and health conditions, and hospital processes. It has been a road paved with lessons, and also of inspiration, from you, our patients, readers, our medical and nonmedical advisors, and advertisers. As we chart our next course to take this publication to the next phase, we will take a break from publication and return with a bigger, better newspaper and a new name later this year. Thank you for your continued support!

Deputy Head & Senior Consultant Of National Cancer Centre Singapore (NCCS)’s Department of Surgical Oncology. “The main challenge was in getting the sequence right while doing a technically perfect surgical operation.” The complex surgery – involving the donor, heart and liver transplant teams – would have to work like clockwork with the handover between each team seamless to make sure the recovery of the transplanted organs wasn't compromised. The teams wouldn’t know when the surgery would be scheduled – it would depend on when a donor became available. Thus, well before that happened, the teams had to ready a plan with detailed steps for the transplant procedures, and the sequence of these steps. The transplant teams brainstormed about the problems that could arise, and formulated backup plans in the event they do surface. It was also crucial for the support teams to know their role and responsibilities. The coordinators, anaesthetists, operating room staff, ICU (intensive care unit) staff, pharmacists, physiotherapists, medical social workers – all needed to know how and when they should work with the others if the CONTINUED ON PAGE 5


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