Nano based strategies to enhance the oral delivery of anti-cancer therapeutics Usama Ahmad1, Abdul Qadir1, Md. Faiyazuddin2, Juber Akhtar1 1. Faculty of Pharmacy, Integral University, Lucknow, India-226026 2. College of Pharmacy, University of Hail, Hail City, KSA
Email: usamaahmad.10@outlook.com
Mob. No: +919554333085
INTRODUCTION Nanotechnology offers many potential benefits to medical applications including the early detection of cancers and cancer treatment, passive and active disease targeting, increased biocompatibility, and multifunctionality encompassing both imaging and therapeutic capabilities, allowing for simultaneous disease treatment and monitoring both imaging and therapeutic capabilities, allowing for simultaneous disease treatment and monitoring. Nanostructured biomaterials, featuring a nanoscale morphology and size, exhibit a wide range of advantages over the conventional biomaterials, such as high bioavailability, improved cellular interaction, and specific designed functions. It offers a promising solution to many difficulties in drug delivery and tissue engineering.
CANCER - A GLOBAL CHALLENGE Cancer is a leading cause of death group worldwide and accounted for 7.4 million deaths (around13% of all deaths) in 2004. The main types of cancer are: Lung (1.3 million deaths/year) • Stomach (803,000 deaths) • Colorectal (639,000 deaths) • Liver (610,000 deaths) • Breast (519,000 deaths) More than 70% of all cancer deaths occurred in low- and middle-income countries. Deaths from cancer worldwide are projected to continue rising, with an estimated 11.5 million deaths in 2030 [1]
STRATEGIES TO ENHANCE ORAL DELIVERY OF DRUG Nanoemulsion (NE): They are thermodynamically stable isotropic system, containing transparent dispersions of oil and water stabilized by a surfactant having droplet size of less than 100 nm. The nanosized droplets leads to enormous interfacial areas & influence the transport properties of the drug. Solid-lipid nanoparticles (SLNs): It combines advantages of other colloidal systems while minimizing their drawbacks. The matrix of the lipid particle formed is solid and biocompatible therefore it can protect drug molecules against chemical degradation. Emulsomes: It combines features of liposomes & emulsions. They protect the drug Nanoemulsion droplet from harsh gastric environment of the G.I.T & can also be used for targeting to specific Conclusion: Newer approaches are far better tissues. The system acts as a carrier for drugs with poor water solubility. than conventional methods for delivering drug Polymeric Nanoparticles (PNs): PNs are solid and spherical structures of about 10-1000 nm in size, prepared from biodegradable & biocompatible polymers to provide and treating cancer. References: controlled release at the desired target site. They can appear either as nanocapsules 1. ‘Cancer’ NMH Fact sheet January 2010. WHO and/or nanospheres. PNs can be successfully delivered to cancer cells, and this can www.who.int/cancer be achieved either by active or passive targeting approaches. 2. Raffa V, Vittorio O, Riggio C, Cuschiery A; 2010. Progress in nanotechnology for healthcare, In: Other approaches include carbon nanotubes, dendrimers, liposomes & Minimally Invasive Therapies & Allied Technologies, cerasomes. 19,127-135
Poster presented during ‘5th Virtual NANOPOSTER event 2015' organised by ‘International Nanoscience Community’