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Chemotherapy-Induced Neuropathy: Cumulative Dose A suspicion of chemotherapy-induced neuropathy can be clarified with five questions:
1) What symptoms does the patient have? The first signs are sensory disturbances such as tingling or burning sensation, numbness, muscle Weakness/twitching, or pain in the soles of the feet or on the toes or fingertips.
2) With which substance class was the patient treated? Platinum, taxanes, epothilones, and vinca alkaloids can be an indication of the presence of a chemotherapy-induced disease.
3) What dose was given? The decisive factor is usually the total cumulative dose of the substance used. The symptoms usually appear from the third or fourth cycle and then increase. Patients generally react differently to different doses.
4) When did the chemotherapy take place? Up to one year after the end of the therapy, this can be considered as the cause of the symptoms.
5) Which other causes are to be distinguished? • Alcohol abuse, diabetes mellitus, or metabolic disorders such as kidney failure • Other drugs: Metronidazole, INH, amiodarone or diphenylhydantoin • Monoclonal gammopathies (MGUS) • Disorders of the absorption of vitamin B12 or folic acid.