2018 Primate Research Product Catalog
Advancing primate research with disruptive technologies and innovative solutions CONTENTS • Matrix Array™ features a true 3D electrode site arrangement (up to 15 mm deep) capable of spanning cortical columns and layers. The Matrix Array™ can also be configured with Surface Grids for combined depth and ECoG recording and/or stimulation. (p.4-8) • Matrix Insertion Tool allows for micron-scale computer-controlled insertion (p.9) • The vDrive chamber microdrive can extend the longevity of chronic experiments (p.11) • Vector Array™ is designed for chamber-based experiments and can be configured in lengths between 70 mm and 115 mm. The Vector Array™ can be configured for daily penetrations or head-mounted chronic use. (p.12-13) • Catalog Primate Electrode Array Designs begin on p.16. Contact us for custom designs.
Building on our industry-standard silicon probe technology, for 2018 NeuroNexus is offering an expanded line of products specifically designed for primate research. NeuroNexus works closely with researchers to develop our products, and utilize advanced manufacturing techniques to make these designs a reality. If you are interested in a tailored neural interface, please get in touch with us for a consultation.
F I N D U S O N YOU TUBE The NeuroNexus YouTube channel provides detailed demonstrations of implantation strategies for various products, including the Matrix Array and Vector Array. youtube.com/TheNeuroNexus
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Cover: Matrix Array™ (Smart Package) on a Primate skull Facing page, clockwise from top left: Matrix Array™, Vector Array™, Optogenetics Matrix Array, Matrix Insertion Tool
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Silicon Platform
Matrix Array™ TRUE 3 D NE URAL INTE RFACE 2D Arrays
The Matrix Array™ is our 3-dimensional probe, designed with proven silicon technology and optimized for both acute and chronic experiments in animal models as large as non-human primates. The Matrix Array™ concurrently spans cortical columns and layers, interfacing with large populations of neurons in 3D space.
Overall tissue coverage
• • • • • • •
Electrode sites Recording coverage at electrode site
•
High density: 64, 128, and 256 channels Optimized tip profile minimizes tissue trauma during insertion Record immediately after implant Durable connector and ultra-flexible cable Sterilizable Capable of recording and/or stimulation Capable of interfacing with cortical and/or subcortical areas as well as on the surface Variety of connector interfaces, including Blackrock headstages
Left: Closeup of a 2 mm Matrix Array™, illustrating recording/stimulation coverage in 3-dimensional space. The shown design uses the M4x8-2mm-200-400-703 array with the 600 µm spacing platform. Coverage will vary based on electrode and platform selections.
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The support structure of the Matrix Array™ is a silicon platform where our industry-standard 2D silicon electrodes can be installed. Both the slot spacing and the 2D electrode array combination can be customized, giving you unsurpassed flexibility in customizing a true 3D probe capable of spanning any anatomical structure. An ultra-flexible cable assembly connects the Matrix Array™ to conventional percutaneous connectors. • • •
• •
2 mm
10 mm
Customize electrode length, site area, spacing Combine different 2D electrode array designs for a tailored neural interface Silicon platform comes in 4 sizes for different 2D array spacing: 200 µm, 300 µm, 600 µm, and 1000 µm Penetrating arrays can be combined with surface ECoG grids See design library (p.15-30) for a set of off-theshelf designs
Right: Illustrations of potential Matrix Array™ configurations. Top: Combine short and long array designs to target both the sulcus and gyrus. Middle: Combine array designs of different lengths to target adjacent cortical layers. Bottom: Combine depth probes with surface grids.
Depth Probes (32 channels each)
Depth Probes (32 channels each)
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Surface Grid (32 channels)
PA C K A G E S A N D H E A D S TA G E I N T E R FA C E Small Animal Chronic
The Matrix Array is available in a wide variety of packaging options to suit almost any application: • • • • • •
Large Animal Chronic (including Primate) Small Animal Chronic Acute MRI Smart-enabled Optogenetics-enabled
64 Channel (left) and 128 Channel (right) Matrix Arrays™ Additionally, the Matrix Array can be configured as a single platform (above left), dual platform (above middle, Smart Matrix package shown), or as a combined system utilizing both penetrating arrays and a surface electrode (above, right).
The Small Animal Matrix Array package comes in 64 and 128 channel variants, and connect to commonly available headstages and systems.
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PA C K A G E S A N D H E A D S TA G E I N T E R FA C E Large Animal Chronic
Self-Aligning Adaptors
Dual Platform Matrix Array™ with Primate Pedestal Adaptors are available to connect the Matrix Array to any system. The Matrix HD package utilizes a self-aligning adaptor (above image) that connects simply with force applied via a torque wrench, reducing strain on the package and animal.
The updated Matrix HD package uses a durable high-density connector, allowing for a smaller overall package. A customizable machined titanium pedestal securely anchors the connector package to the skull. Self-aligning adaptors enable connection to existing systems.
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Extensively tested. To ensure the Matrix Array™ withstands the rugged experimental environments of primate applications, exhaustive testing of both the probe and insertion method was performed in the labs of collaborators.
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A smarter way to perform insertions. Designed in response to scientific feedback, the Matrix Insertion Tool allows for extremely precise, low speed insertions to reduce tissue damage and minimize recovery time. • • • •
Insertion speed adjustable between 0.5 µm/s 8 mm/s (4.5 mm/s recommended) Computer-controlled linear actuation Attaches to standard stereotaxic manipulator or All-Angle Manipulator (shown left, top) Matrix Array™ mounts on suction tip
Left: The Matrix Insertion Tool (Top) mounted on the All-Angle Manipulator. The Insertion Platform (Bottom) allows fine-tuning in 2 axes. Combined, these accessories greatly improve the probe positioning and insertion experience.
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M ATRIX ARRAY ™ SPECIFICATIO N S Channel Count
64, 128, 256
Array Spacing
300 µm, 600 µm, or 1000 µm (specify when ordering)
X-Y Span
1.8 mm x 1.8 mm / 1.8 mm x 3 mm (customizable)
Z Span
Up to 15 mm (customizable)
Cable Length
30 mm (customizable up to 50 mm)
Electrode Site Material
Iridium (standard), Platinum (custom), Gold (custom)
Electrode Thickness
50 µm
Available Packages
Acute Y-Bracket, Small Animal Chronic, Primate Pedestal
M ATRIX IN SERTIO N TO O L SPECIF ICAT IO N S Insertion Speed
0.5 µm/s - 8 mm/s
Travel Range
0 - 50 mm
Step Size
0.05 µm
Dimensions
150 mm (L) x 30 mm (W) x 20 mm (H)
Probe Attachment
Vacuum tip (hose must be attached)
Insertion Tool Attachment
Stereotaxic manipulator
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vDrive C HAM BE R M ICRO DRIVE SYS TEM The new vDrive is a chronically head-mounted microdrive designed to be used in primate prep. Based on the widely used dDrive, the vDrive microdrive can increase the effectiveness and longevity of chronic experiments. • • • • • •
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Compatible with Vector Arrays™ and standard probes 7 mm drive range (customizable) 150 µm/turn drive resolution (customizable) Probe position can be adjusted in 3 axes (x, y, z) Multi-drive capable Compatible with commercially available recording chambers such as those from Grey-Matter Research
Vector Array™ DE E P BRAIN NE URAL INTER FACE The Vector Array™ is optimized for large animal deep brain applications (e.g. non-human primate, porcine, etc). The probe design is completely overhauled to fully take advantage of our industry-leading silicon probe technology. The proximal body of the Vector Array™ is made of a rigid metal tube (Support Body), while the distal end interfacing with the target region is a customizable NeuroNexus silicon electrode array. This hybrid assembly combines a high-quality, proven neural interface at the critical region while providing the elongated probe system with a robust body.
Above: 32 Channel Vector Array™, left, and 16 Channel Vector Array™, right Right: Narishige Vector Array™ Guidetube Loader
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Features: • • • • •
• • • • •
Configure for acute daily penetrations or chronic use 16, 32, 64 channels Minimal tissue damage 10 mm or 15 mm electrode length 60 mm or 100 mm support body length. Add electrode length to obtain total implantable length. Augment with optical fiber for optogenetics work Combine with pDrive for microdriveenabled chronic experiments Customizable length and site layout See design library (p.31-35) for a set of off-the-shelf designs Jumper cable available to simplify connection between probe and headstage
Closeup of Vector Array tip, showing 32 channel Edge array
Chronic Vector Array on vacuum inserter
Vector Arrays can be configured with optical fibers
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vDRIV E SPECIFICATION S Drive Range
7 mm
Channel Count
16, 32, 64, 128 (Smart only), 256 (Smart only)
Drive Resolution
150 µm/turn (customizable)
Chamber Compatibility
Can be customized to fit any chamber
VE CTOR A RRAY ™ SPECIFICATIO N S Channel Count
16, 32, 64
Silicon Electrode Length
10 mm or 15 mm
Support Body Length
60 mm or 100 mm (Add Electrode Length to obtain total Implantable Length)
Site Layout
Edge or Poly2 (customizable)
Site Coverage
375 µm to 6300 µm, depending on design
Silicon Electrode Width
20 µm (min), ≈ 175 µm (max)
Electrode Thickness
50 µm or 200 µm
Support Body Diameter
315 µm OD (16-ch), 400 µm OD (32-ch, 64-ch)
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How to Configure a Matrix Array™ Step 1: Select 2D Arrays (p.13-28). You may combine different 2D Arrays in your selection, or include ECoG arrays (p.27-28) for combined depth and surface recording. Step 2: Select a platform spacing. The illustration below shows tissue coverage with the 3 different platform spacings available. In this example, the M4x8-2mm-200-400-703 (p.19) is used; to calculate tissue coverage for your design, use the dimensions available on the following pages. 4 platform spacings are available: 200 µm, 300 µm, 600 µm, and 1000 µm. 300 µm spacing
600 µm spacing
1000 µm spacing
z z
x x: y: z: volume:
1200 µm 900 µm 1400 µm ≈ 1.512 mm3
y
z y
x x: y: z: volume:
1200 µm 1800 µm 1400 µm ≈ 3.024 mm3 15
y x x: y: z: volume:
1200 µm 3000 µm 1400 µm ≈ 5.04 mm3
M AT R I X A R R AY
M2x16-2mm-100-1650-703
1500 µm
703 µm2
2 mm
100 µm
1650 µm
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M AT R I X A R R AY
M4x8-var-Buz
52 µm
37 µm 33 µm 29 µm
160 µm2
25 µm 21 µm
1.5 mm
17 µm 600 µm
1000 µm
20 µm
32 µm (min)
35 µm
333.33 µm 8.5 µm 1800 µm
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40 µm
175 µm
M AT R I X A R R AY
M4x8-2mm-25s-Poly3-200-177
79 µm 50 µm 25 µm 74 µm 2 mm
177 µm2
110 µm
200 µm 600 µm
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M AT R I X A R R AY
M4x8-2mm-50-200-177 M4x8-2mm-50-200-703
350 µm 177 µm2 2 mm
703 µm2
50 µm 38 µm 177 µm2 Site Area 200 µm 600 µm
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703 µm2 Site Area
M AT R I X A R R AY
M4x8-2mm-100-200-177 M4x8-2mm-100-200-703
700 µm 177 µm2
703 µm2
2 mm
50 µm 38 µm 177 µm2 Site Area 200 µm 600 µm
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703 µm2 Site Area
M AT R I X A R R AY
M4x8-2mm-200-400-703
1400 µm
703 µm2
2 mm
200 µm 41 µm
400 µm 1200 µm
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M AT R I X A R R AY
M4x8-5mm-Buz-200
52 µm
37 µm 33 µm 29 µm
160 µm2
25 µm
5 mm
21 µm 17 µm
20 µm
32 µm (min)
35 µm 8.5 µm
600 µm
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40 µm
175 µm
M AT R I X A R R AY
M4x8-5mm-25s-Poly3-200-177
79 µm 50 µm 25 µm 74 µm 5 mm 177 µm2
110 µm
600 µm
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M AT R I X A R R AY
M4x8-5mm-50-200-177 M4x8-5mm-50-200-703
350 µm 177 µm2
5 mm
50 µm 38 µm 177 µm2 Site Area 600 µm
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703 µm2 Site Area
M AT R I X A R R AY
M4x8-5mm-100-200-177 M4x8-5mm-100-200-703
700 µm 177 µm2
5 mm
703 µm2
50 µm 38 µm 177 µm2 Site Area 600 µm
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703 µm2 Site Area
M AT R I X A R R AY
M4x8-5mm-150-200-177 M4x8-5mm-150-200-703
1050 µm 177 µm2
703 µm2
5 mm
150 µm 41 µm 177 µm2 Site Area 600 µm
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703 µm2 Site Area
M AT R I X A R R AY
M4x8-10mm-Buz-200
52 µm
37 µm 33 µm 29 µm
160 µm2
25 µm
10 mm
21 µm 17 µm
20 µm
32 µm (min)
35 µm 8.5 µm
600 µm
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40 µm
175 µm
M AT R I X A R R AY
M4x8-10mm-100-200-177
700 µm 10 mm 177 µm2
100 µm 38 µm 600 µm
200 µm
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3.4 mm
M AT R I X A R R AY ( E C O G )
2.75 mm
EM32-400-600-58-200 400 µm
600 µm
58 mm 200 µm (dia) 100 µm (dia) Matrix Array Platform (400 µm shank spacing, 600 µm platform spacing)
31,420 µm2
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9 mm
M AT R I X A R R AY ( E C O G ) 9 mm
EM32-2000-55-200 1 mm
2 mm
55 mm
200 µm (dia)
Matrix Array Platform (1000 µm platform spacing)
31,420 µm2
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V E C TO R A R R AY
V1x16-Edge-10mm-100-177
184 µm (max)
10 mm
177 µm2
115 µm (max) 100 µm 20 µm (min)
1500 µm
40 µm
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V E C TO R A R R AY
V1x16-Poly2-10mm-50s-177 102 µm (max)
184 µm (max)
25 µm 50 µm
10 mm
50 µm 375 µm
177 µm2 68 µm (min)
75 µm
43.3 µm
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V E C TO R A R R AY
V1x32-Edge-10mm-100-177
175 µm (max)
10 mm
177 µm2
20 µm (min)
3100 µm
100 µm 40 µm
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V E C TO R A R R AY
V1x32-Poly2-10mm-50s-177
184 µm (max)
184 µm (max)
775 µm
10 mm
50 µm
177 µm2
75 µm (min)
50 µm 25 µm
75 µm 43.3 µm
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V E C TO R A R R AY 172 µm
V1x64-Edge-10mm-100-177
177 µm2
6300 µm
10 mm 100 µm
20 µm (min)
40 µm
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NOTES
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