NeuroNexus Neuromodulation Brochure

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Advancing neuromodulation research


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NeuroNexus is the global leader in neuroscience research. Now expanding into clinical research. NeuroNexus is an official NIH BRAIN Initiative® partner.

Originally developed at the University of Michigan, NeuroNexus’ suite of commercialized technologies has, for over a decade, led to hundreds of publications from research labs all around the world. Our products include conventional and high-density leads, recording and stimulation systems, and software for data analytics. Our products have been used in a wide variety of animal models from fruit fly to rodent to non-human primates. NeuroNexus is currently working to make our state-of-the-art technologies and systems available for human clinical research.

Currently not available for sale

Next page, clockwise from top left: Matrix Array™, Vector Array™, SmartBox™, Quad-fiber Optoelectrode. See the NeuroNexus Research Product Catalog at neuronexus.com for more information.

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NeuroNexus is at the intersection of neuroscience, technology, and clinical drivers. Science drivers: NeuroNexus powers leading-edge neuroscience research around the world

Clinical drivers: NeuroNexus is uniquely positioned to translate new technologies into innovative neuromodulation systems

Technology drivers: NeuroNexus continually innovates neural interfaces to meet the needs of both scientific and clinical research

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Core Technologies and Competencies • High resolution thin-film technologies utilizing silicon and polymer materials • Draw from our design tools and libraries for advanced thin-film neural interfaces • Translation of leading-edge concepts into commercial solutions • Computational modeling and analysis of neural interface devices and systems • Rapid prototyping • Resources and expertise for testing and validation • Collaboration and networking with leaders in the clinical and neuroscience fields

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Custom Design NeuroNexus offers a custom lead design service that provides unique access to a virtually unlimited design space. Almost any feature of a lead can be tailored to suit your application - and all it takes to get started is a sketch. Each custom lead includes: • Consultation with our engineering team to validate feasibility of your proposed design • Translation of your design into a CAD layout • Formal design review with our technical team • State-of-the-art microfabrication of your design • Packaging and testing of the fabricated devices • Ability to imprint text (such as your name) on the lead

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NeuroNexus offers both conventional and high density lead technologies.

Conventional Lead Technologies

High Density Lead Technologies

• History of clinical use • Robust mechanical properties • Body compliant

• High channel count, high density • Ultra flexible • Can be integrated into form factors of conventional systems • Customizable shape and electrode coverage

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LEADS FOR BRAIN/SPINAL CORD SURFACE

Images not to scale.

SPE CIFICATIO N S

Conventional

HD

Number of Channels

8, 12

16, 32, 64+, customizable

Substrate

Silicone/Polyurethane, millimeter thickness

Thin-film, micron thickness

Flexibility

Body compliant

Ultra-flexible

Electrode Material

Platinum Iridium

Platinum

Electrode Coverage

Millimeter spatial resolution

Micron spatial resolution

Impedance

kΩ range

kΩ - MΩ range

Maximum current

mA

µA - mA

Usage

Stimulation

Stimulation, Sensing (ECoG, µECoG, CAP)

Regulatory Status

FDA Approved

In Process

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LEADS FOR DEEP BRAIN MAPPING OR STIMULATION

Images not to scale.

SPE CIFICATIO N S

Conventional

HD - Stimulation

HD - Mapping

Number of Channels

8, 12

24, 48, customizable

16, 32, customizable

Substrate

Silicone, millimeter thickness

Thin-film with silicone/ polyurethane backing

Thin-film combined with conventional wire

Electrode Material

Platinum Iridium

Platinum

Platinum

Electrode Coverage

Millimeter spatial resolution

Micron spatial resolution

Micron spatial resolution

Impedance

kΩ range

kΩ - MΩ range

kΩ - MΩ range

Maximum current

mA

µA - mA

µA - mA

Usage

Stimulation

Stimulation, Sensing (AP, LFP)

Stimulation, Sensing (AP, LFP)

Regulatory Status

FDA Approved

In Process

In Process

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INTRACORTICAL LEADS

SPE CIFICATIO N S

HD

Number of Channels

64, 128

Substrate Material

Silicon

Electrode Material

Iridium

Electrode Resolution

< 50 µm, customizable

Usage

Stimulation (electrical and optical), Sensing (Action potential, Field potential)

Regulatory Status

In Process

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NERVE LEADS

Images not to scale.

SPE CIFICATIO N S

Conventional

HD

Number of Channels

2-3

12, 24, customizable

Substrate

Silicone/Polyurethane, millimeter thickness

Polyimide, micron thickness

Flexibility

Flexible

Ultra-flexible

Electrode Material

Platinum Iridium

Platinum

Electrode Coverage

Millimeter spatial resolution

Micron spatial resolution

Impedance

kΩ range

kΩ - MΩ range

Maximum current

mA

µA - mA

Usage

Sensing

Sensing, Stimulation

Regulatory Status

FDA Approved

In Process

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Clinical SmartBox™ Platform - Recording Module*

LE AR N MORE Visit our YouTube channel to learn more about our products: youtube.com/TheNeuroNexus

The NeuroNexus SmartBox™ is a portable control and data acquisition system. • State-of-the-art technology, affordable pricing • Record up to 256 channels simultaneously • Up to 30 kHz sampling rate per channel • 16-bit ADC resolution, 15 µV smallest detectable signal • Electrode diagnostic (impedance check) and site conditioning mode • Wide variety of signals supported: EEG, EMG, action potential, field potential, pulsation • Portable with optional battery pack - take your recording system and laptop with you, and record from anywhere

Above: SmartBox™

• DAC out for audio monitoring

Inset: GUI

• Arrives ready to go, with minimal setup required; Laptop included

*Available in 2016

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Clinical SmartBox™ Platform - Stimulation Module*

Desktop Stimulation Module

• Can be integrated to perform simultaneous recording and stimulation • 25 stimulation channels with independent constant current sources • Stimulate up to 15 mA • Highly flexible programming to support advanced stimulation protocol

Wearable Stimulation Module

• Wirelessly controlled (up to 1 meter range) • Can be battery powered (2 weeks of operation with typical usage) • Arbitrary waveform generation • Implantable, wearable, and desktop versions available

Implantable Stimulation Module Images not to scale.

*Available in 2016

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Surgical Consultation & Neural Analytics Adapting to new technology and techniques can be difficult. NeuroNexus staff engineers and scientists have decades of combined experience, and we can help you reduce your ramp-up time so you can focus on your research.

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NOTES

Currently not available for sale

655 Fairfield Ct., Ste. 100 / Ann Arbor, MI 48108, USA neuronexus.com / +1.734.913.8858 (Phone) / +1.734.786.0069 (Fax)

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