The meter features a spectral range of 340nm to 900nm allowing for a wide selection of analytical methods.
Vial rotation during measurement allows for method identifi cation and for a number of absorbance readings. The instrument then converts the readings to concentration units and the result is shown on the LCD display.
HI802 iris spectrophotometer quickly identifi es Hanna Instru-ments vial methods by reading the barcode on reagent vials across multiple methods that support the use of a single-zero measurement.
•Automatic method identifi cation of barcoded sample vials
•Removeable barcode reader for maximum versatility
•Advanced split beam optical system
•Rechargeable li-ion battery
•User customizable methods
•Average function up to 256 readings
UNIQUELY AFRICAN
CUTTING EDGE DNA SEQUENCING AND GENOTYPING SERVICES @ INQABA BIOTEC!
We offer services on Revio and Onso instruments from PacBio to produce HiFi long-read and high quality short-read sequence data, respectively.
inqaba biotec, a uniquely African genomics company was established back in 2002.
Headquartered in Pretoria, South Africa, the company now boasts subsidiaries in both East and West Africa providing the sub-Saharan continent with leading scientific brands (such as NEB, Zymo Research and Eppendorf) and diagnostic brands (such as Seegene). In addition, inqaba biotec offers an impressive range of molecular services worldwide from oligo synthesis to genotyping to NGS services from our state of the art laboratories in Pretoria.
In need of high quality genomes, transcriptomes and bioinformatics support?
Use inqaba biotec - a PacBio certified service provider!
The future of green ammonia production through electrochemistry holds great promise for sustainable agriculture and energy LIFE
Biologic SP200 PGSTAT acquired by the CorroSci research group at the University of Venda
The HI802 iris spectrophotometer quickly identifies Hanna Instruments’ vial methods
Air & Vacuum Technologies proudly represents Endecotts, the
Sanger DNA sequencing service launch at inqaba biotec, East Africa
Rainin’s SmartCheck is a quick and easy way to check if pipettes are dispensing accurately
It’s time for a laugh
Dear Reader
Here we are with the last issue for 2024. It’s been a crazy year that has flown past in the blink of an eye. Well, that’s how it feels to me! So, I figured we could all do with something light-hearted that will put a smile on our faces as we wind down towards the year-end.
I came across an article about the 2024 Nikon Comedy Wildlife Awards - photos of an ant looking down on us, smooching owlets, and a tiny flying squirrel doing its best impression of a crime boss - these are just some of the visuals I had to share.
The awards were founded in 2015 by professional photographers Paul Joynson-Hicks and Tom Sullam. They wanted to fuse exceptional wildlife photography with the power of humour in a bid to promote the conservation of wildlife and habitats. This year, the competition received a record number of entries - just under 9 000 in total, from 98 different countries.
Each year the competition supports a sustainable conservation organisation. This year it is working with the Whitley Fund for Nature - a UK-based charity that supports conservation leaders working in their home countries across the Global South.
Photographer Alexander Pansier captured this image of a red ant looking down on us in the Netherlands last autumn. He named it ‘Hello World’. “I liked the tones of this autumn leaf. So warm,” Pansier says. “It was hard to take this image because of the fast-moving ant, but with a little help of a flashlight I was able to freeze the motion.”
Sarthak Ranganadhan, who took this photo of ‘Smooching Owlets’ in Gurgaon, India, says: “Our parents always find a way to embarrass us; I guess that’s also true in the case of spotted owlets.”
Ranganadhan says it was funny to see the spotted owlets attempting to get some privacy while their little offspring stood right next to them.
Felicity.Garbers@newmedia.co.za
Photographer Przemyslaw Jakubczyk captured this image of a bream appearing to chase a bald eagle at Szczecin Lagoon in Poland. “Every annoyed and overtired fish needs to de-stress by hunting for a bald eagle,” Jakubczyk jokes. He named his photo ‘Unexpected Role Swap’.
Photographer Takashi Kubo took this photo of a flying squirrel in Hokkaido Japan. “It looked like he was sucking a cigar, and he looked like a mafia boss,” Kubo says.
This image of southern rockhopper penguins was taken on Pebble Island in the Falkland Islands. “On the penguin highway, these rockhoppers are moving into town, and this town ain't big enough for all of them,” photographer Ralph Robinson jokes. “I set up my camera a good distance from this ridge where rockhopper penguins were returning from feeding in the southern Atlantic Ocean in the Falkland Islands,” Robinson says, adding that they looked ready for a fight.
Photographer Artur Stankeiwicz positioned himself on the bank at Mana Pools National Park in Zimbabwe, hoping to catch a fight between the hippos.
But they were all peaceful, with a few raising their heads to investigate his presence. Instead, Stankiewicz got the idea of capturing this portrait with water plants decorating a hippo’s head.
“It looked like the guy just got out of the hairdresser with a big smile on his face.”
He named his photograph ‘I’m Too Sexy for my Love’.
“I
is a universal concept’.
So, now it is time to wish you all a very happy and safe festive season. We are nearly on page 365 of the 365-page yearbook. Are you ready to close this book and start a new one? I know I am.
Scott Frier likes this photo because it is reminiscent of an old TV commercial.
have this image printed and hung on a wall of my home. Everybody who sees it laughs at it.” He named his photo ‘Nagging
2024 was a year filled with lots of success and many highlights, including the opening of our new premises in KZN. To all our loyal, and new customers, thank you so much for your support and faith in Metrohm. We truly appreciate it. Merry Christmas and Happy New year.
The Automated Coagulation Analyzer MC550 performs tests by coagulation, immunoturbidimetric, and chromatic substrate method mainly used in emergency test of medium to high-risk patients, also better meets the demand for automatic test of smaller Labs.
S P E C I F I C A T I O N S
APTT (Activated Partial Thromboplastin
Time) mixing study is a laboratory test used to assess the clotting ability of blood
It is performed to investigate the presence of clotting factor deficiencies, inhibitors, or abnormal antibodies that may cause prolonged clotting times. This helps to differentiate between a factor deficiency and the presence of an inhibitor.
Whole blood sampling
It is commonly used in point-of-care testing and emergency situations where quick results are required
Internal centrifuge
This saves time and reduces the risk of sample contamination
Multiple type of sample: Venous, whole blood, plasma
Easy to operate and flexible
INTRODUCTION TO BELLINGHAM & STANLEY
Innovators in polarimetry and refractometry
With over a century of expertise and innovation, Bellingham & Stanley, a Xylem brand, is globally recognised for its high-quality digital refractometers, polarimeters and density meters. Now supported locally by Labotec, with their pioneering optical technology, these instruments cater to the rigorous demands of industries such as food and beverage, chemical, petrochemical, and pharmaceutical. Their refractometers and DSG Series density meters are known for their versatility and user-friendly interfaces. They offer touchscreen and keypad models for various applications, including laboratory research and field measurements, and comply with FDA 21 CFR Part 11 for data protection.
Refractometer Series
Bellingham & Stanley offers one of the most extensive selections of digital refractometers available today. From high-end digital touchscreen refractometers designed for laboratory use to handheld models for field measurements, these instruments cater to a wide range of needs. Each refractometer features flat, easy-clean prism dishes and ergonomic casings to manage spills efficiently.
USB connectivity and user-friendly software are standard across the range, providing ease of use and peace of mind with accurate, repeatable results.
Touchscreen Refractometers
RFM300-T Series
The RFM300-T Series is tailored for demanding applications in the food, beverage, chemical, and industrial sectors. These units are designed to handle non-homogenous samples such as fruit juice with pulp, opaque chemical compounds, and emulsions. Key features include:
• Three decimal place Brix precision digital refractometer with Peltier temperature control
• Touchscreen interface
• Easy clean prism
High accuracy (±0.01°Brix)
• Smart temperature stability
• Secure PDF printing Dual-scale display
RFM900-T Series
The RFM900-T Series offers high precision with Peltier temperature control and a wide
measuring range up to 1.70 RI. These refractometers are ideal for applications in the chemical, petrochemical, pharmaceutical, flavours, and fragrance industries.
Key features include:
Six decimal place Refractive Index precision digital refractometer
• Wide RI range up to 1.70 Highest precision (±0.000005RI)
• Conformance to ASTM standards
• Material traceability certificate available USP Class VI / FDA materials
• MEAN Method (USP/EP/BP)
Keypad Refractometers
RFM300-M Series
The RFM300-M Series features a durable membrane made from chemical and scratchresistant polyester, offering a tactile interface for menu navigation.
Key features include:
• High-precision Peltier temperaturecontrolled benchtop refractometers Durable display with RFID technology
• On-screen prompts for simple operation
• User-defined methods or selection from an on-board library
RFM700-M Series
The RFM700-M Series is robust, cost-effective, and fully automatic, suited for the food, sugar, and beverage industries, as well as other nonfood applications.
Key features include:
• Alphanumeric keypad Classic red or modern colour display
• Multiple scale options
• Comprehensive audit trail (date, time, batch & operator)
Digital Density Meters:
DSG Series
The DSG Series density meters are highly reliable and easy to use, featuring two unique models for flexibility. They are equipped with a large capacitive touchscreen and intuitive GUI, guiding users through tasks with ease.
Notable features include:
• Peltier Temperature Control and precision ventilation ports for rapid temperature stabilisation
• No need for external devices for venting after cleaning, thanks to an internal air pump and integrated desiccant
• 15-second read time
• FDA 21 CFR Part 11 compliance with onboard data protection and full audit trails
• Touchscreen operation with optional keyboard and mouse support
Applications of DSG
Density
Meters: Pharmaceutical: Density measurement in pharmaceuticals is crucial for batch testing, production control, and raw material analysis, with DSG Density Meters meeting strict standards in over 100 pharmacopoeia monographs
• Alcohol (beer, wine, cider & spirits): Producers use density meters to monitor quality and calculate alcohol percentage accurately. DSG Density Meters provide detailed information from a single sample, essential for quality control and regulatory compliance
Industrial: The closed-loop nature of DSG Density Meters prevents evaporation, ensuring accurate measurements of volatile organic compounds. They are ideal for biodiesel, petroleum products, and harsh chemicals, with automatic postmeasurement cleaning for safety Food & Beverage: Density measurement is vital for quality control in the food and beverage industry, from raw materials to final product checks. DSG Density Meters assess sugar content and other key parameters, ensuring product quality and consistency
HIGHLIGHTS
COLDBLOCK PROVIDES THE ANSWER TO ASSAYING PROCESSES
Historically, gold-copper mining operations have had to rely upon two separate assaying methods: fire assay for gold and hot plate digestion for copper. Fire assay is a common, time-honoured, multistep assaying method that takes hours to complete, requires a high degree of expertise, and necessitates the use of lead fluxes and the requisite safety measures. The hot plate digestion method used for copper also requires multiple steps and takes hours to complete.
Benefits realised by mining laboratories since introducing ColdBlock into the assaying process include:
Shorter turnaround times – Samples being sent from the mill and mine teams to the lab require accurate determination of elemental content in a timely manner. With fire assay methods, it can take a day or longer to generate assay results. With ColdBlock, labs are now able to provide results to the operating groups within hours.
Reduction of lead exposure – The gold fire assay process requires the use of lead as a reagent. Employee lead exposure is a risk, and regular testing is required. With ColdBlock digestion technology, mining companies are significantly reducing the use of fire assay, which has led to a meaningful reduction in risk of lead exposure for the team.
Precision and accuracy – Mining companies have reconfirmed the accuracy and precision of results received, using ColdBlock/ICP-MS process as part of their QA/QC process. This has been done by comparing ColdBlock results against duplicates run through the fire assay facility, and through independent global commercial lab partners.
Cost savings – Assaying with two separate methods (as is common with polymetallic precious/base metal mining operations) is not just time-consuming but costly. Reducing fire assay needs and relying on a single assaying method with ColdBlock results in significant savings in time, labour and consumables.
TAKE YOUR SEPARATIONS TO THE MAX WITH MAXPEAK PREMIER COLUMNS
The ultimate solution for your chromatographic separations
Waters MaxPeak Premier Columns enable scientists to have more confidence in their chromatographic separations with the inclusion of MaxPeak High Performance Surfaces (HPS) Technology. MaxPeak HPS Technology is designed to increase analyte recovery, sensitivity, and reproducibility by minimising analyte-to-surface interactions that lead to sample losses.
MaxPeak Premier Columns mitigate the loss of metal-sensitive analytes, such as
lipids, organic acids, acidic peptides, oligonucleotides, and other compounds containing phosphate, carboxylate, or other chelating functionalities. Chelation of compounds with stainless-steel surfaces can lead to inconsistencies in analytical results. With expanded particle size options, you can now use MaxPeak Premier Columns to create and transfer methods, from development to QC, using any LC system.
Key benefits of MaxPeak Premier Columns:
• Reduced column conditioning and passivation times
Improved sensitivity and sharper peak shapes
• Simpler mobile phases without the need for complex additives
• Time savings in method development
• Reduced risk and greater confidence in data and decision making
MICROTRAC SYNC
A new dimension in particle analysis
With the SYNC particle analyser, Microtrac MRB integrates its highly accurate tri-laser diffraction analyser technology with its versatile dynamic image analysis capability to provide particle characterisation practitioners with a unique measuring experience.
The patented synchronous measurement technology allows users to make both a laser diffraction measurement and an image analysis measurement on a single sample, in the same sample cell at the same time.
One sample
• One optical bench
• One flow path
One sample cell
• One analysis
The SYNC laser diffraction particle size analyser is ideally suited for routine QC applications. It also provides valuable information to researchers as they develop new materials and processes. The powerful analyser software provides both particle size distribution information, as well as a multitude of morphological particle parameters.
The patented BLEND routine allows users to examine materials over a wide range of sizes from 0.01 microns to 4 000 microns.
Versatility is a great strength of laser diffraction analysers.
This makes the method suitable for a variety of applications in both research and industry. Microtrac MRB laser diffraction particle analysers are characterised by especially convenient, easy-to-learn operation. Thanks to their robust design, the instruments are practically maintenance-free and fit for 24/7 operation.
• Scalability across all analytical LC platforms – UPLC – UHPLC – HPLC
Featuring trusted particle technology and an expanding selection of chemistries, MaxPeak Premier Columns provide the flexibility and performance needed for superior chromatographic separations across all applications.
Louis van Huyssteen Tel. 082 773 5518 Tel: 087 092 7300
The high sample throughput and the extremely wide measurement range from nanometres to millimetres are the reasons for the method’s popularity in so many laboratories. However, drawbacks of laser diffraction analysers are poor resolution for large particles, limited sensitivity for oversize, and the inability to measure particle shape. These downsides of laser diffraction, however, are the strengths of image analysis. Thanks to the unique combination of both techniques, the SYNC particle analyser provides information that is not available from laser diffraction alone, and improves the overall accuracy of size measurement.
METROHM 949 PH METER
The 949 pH Meter is Metrohm’s new entry-level benchtop pH meter for modern laboratories. Rely on an easy-to-use instrument for fast and accurate pH, mV, and ORP measurements.
Features:
• Quick and automated pH calibration with built-in buffer tables
Precise results thanks to automated temperature compensation
• GLP-compliant and consistent results with time and date display and adjustable stability criteria
• Clear results on colourful and bright display
• RS232 interface for connecting printer or PC
Compatible with all Metrohm pH electrodes
Trust your results. Additional features, such as reminders for calibration, ensure that your pH meter provides accurate results. This boosts your confidence in its performance. You can print all measured values with their corresponding date and time on the printer. Additionally, if desired, you can include the calibration parameters. The internal measuring memory can store up to 1 000 measuring points. This enables subsequent verification of the values.
Regardless of the sample to be measured, Metrohm offers the right electrode. The 949 pH Meter is compatible with the complete range of Metrohm pH electrodes, ORP electrodes, and temperature probes.
For the past 17 years, Air & Vacuum Technologies have marketed and sold the Absolute BOS - RVD series, a range of robust double-stage highvacuum, oil-flooded rotary vane vacuum pumps made in South Korea. These pumps combine cutting-edge design with exceptional performance, making them ideal for various applications across different industries.
Key features:
• Robust design: The RVD pumps are engineered for durability and reliability. Their sturdy construction ensures longlasting operation even in demanding environments
Ultimate vacuum levels: They achieve impressive vacuum levels, giving the legacy brands a run for their money. Whether you are conducting research or industrial processes, these pumps deliver consistent performance
• Rapid pumping speeds: The RVD pumps efficiently evacuate air, gases, and vapours, allowing for faster cycle times and improved productivity while maintaining a very competitive price point
The versatility of the Absolute BOS - RVD series makes it suitable for a wide range of applications.
We stock the RVD12 (0,37kw) - 10m3/hr up to the RVD 90 (2.2kW) - 75m3/hr but can offer all the way up to the RVD360 (7.5kW) - 270m3/hr. Vacuum levels to 5 x 10-4 mbar abs. We offer exhaust oil mist filters and the required vacuum coupling components. We also carry overhaul kits for the models we’ve sold and offer complete overhauls at our Midrand workshop/engineering works.
GENERAL PRODUCTS
PERMISSIBLE LAB AIR EXPOSURE LIMITS: PROTECTING YOUR HEALTH
In chemistry labs, the risk of inhaling hazardous chemicals is ever present. Erlab specialises in containing, filtering, and returning clean air into the lab to ensure your safety. With 50 years of expertise in chemical filtration, Erlab provides easy safety communication through lights and beeps, remote status filter updates and alerts, full compliance with international filtration safety standard AFNOR NF X 15-211, and a high level of after-sale service from Labotec, the local supplier for Erlab.
Understanding the risks
Chemicals used in laboratories often have strict permissible exposure limits (PEL) set by the Occupational Safety and Health Administration (OSHA) in the USA, which are also applicable in many other countries. These limits are crucial for maintaining a safe working environment.
Exceeding these limits for prolonged periods (eight hours per day) can seriously jeopardise your health. Graham’s Law states that air molecules collide with toxic gas molecules, spreading them rapidly throughout the room, increasing the risk of exposure.
Erlab’s R&D laboratories' eValiQuest analysis looks at the interactions between molecules and validates the filtration technology adapted to your handling. Based on this scientific analysis, the laboratory recommends the type of equipment, filtration column configuration and enclosure size that will ensure your protection.
Limitations of traditional storage and fume hoods
Traditional fume hoods offer high airflow but can generate turbulence,
HI802 IRIS SPECTROPHOTOMETER
The HI802 iris spectrophotometer quickly identifies Hanna Instruments vial methods by reading the barcode on reagent vials across multiple methods that support the use of a single-zero measurement.
The barcode reader for method identification is removable to allow other methods and cuvette adapters (included) to be used for maximum versatility. HI802 iris portable spectrophotometer allows for measurement in the spectrum of all wavelengths of visible light and not just prespecified wavelengths.
Spectrophotometers work by isolating light at specific wavelengths from white light. This compact meter incorporates several features that facilitate both fantastic performance and exceptional usability.
• Automatic method identification of barcoded sample vials
• Removable barcode reader for maximum versatility
• Advanced split beam optical system Rechargeable li-ion battery
• User customisable methods
Vial barcode reader
Automatic method identification of barcoded sample vials is an exciting feature of the HI802. The HI802 visible spectrophotometer scans an inserted barcoded vial and automatically
potentially returning some chemical vapours towards the user through the front sash opening. Additionally, unventilated storage cabinets can release concentrated chemical vapours into your lab when opened, posing an immediate inhalation risk.
This combination of factors makes it critical to choose advanced solutions for chemical handling and storage.
To ensure the safety of your fume hood, containment tests are essential. The SF6 tracer gas containment test verifies that no chemical vapours escape through the front sash opening. According to ASHRAE 110 and ANSI/ AIHA Z9.5-2003 standards, when 4 liters per minute of SF6 tracer gas are injected into the fume hood, a maximum of 0.05ppm should be detected at the nose level of a mannequin.
The Erlab Solution
Erlab’s fume hoods offer advanced solutions for safe chemical handling and storage:
• Superior filtration: Effectively filters gases, solvents, powders, and particulates
Smart technology: Smart-Light Communication indicates the hood’s operational status
Remote monitoring: The eGuard App allows you to monitor the hood, change settings, and receive safety alerts remotely
• Ergonomic design: The 6° slanted sash offers optimal visibility and a comfortable workspace
detects both method type and method range, significantly reducing the risk of errors and aiding measurement procedure.
Vial rotation
Vial rotation during measurement allows for method identification and for several absorbance readings. The instrument then converts the readings to concentration units and the result is shown on the LCD display. This rotational averaging of signals during measurement (with the lamp on) ensures improved method accuracy.
Use of a single-zero measurement across multiple vial methods where blank correction is done with DI water. This ensures that sample features, rather than instrument changes, are reflected in the instrument’s measurements and contributes to ease of use and stable readings.
Universal cuvette holder and auto-recognition
The built-in cuvette holder holds both 22mm round cuvettes and rectangular cuvettes with a 5cm pathlength. Adapters for the cuvette holder are available to hold other 13 and 16mm round cuvettes, and 10mm square cuvettes, including the 13mm vial adapter with barcode reader. Rectangular cuvettes have longer
Case Study: TEFAL Laboratory Challenge and constraints
Tefal conducted a risk analysis to determine the number of fume cupboards needed for the new laboratory. This analysis revealed that the planned ventilation system did not allow for the installation of a sufficient number of fume cupboards, as the building’s extractions had been undersized despite the substantial investment.
Solution
Erlab conducted a chemical hazard analysis ahead of the manipulations to be carried out in the laboratory to propose the best protection solution for the client’s needs. This service is part of the ESP*.
Result
Laboratory personnel now have a sufficient number of fume cupboards to carry out all their handling in complete safety.
Thanks to the installation of filtration fume cupboards, the volume of air treated in the building was reduced, while maintaining an airchange rate of seven changes per hour. The building uses less energy, and operating costs have been reduced. As a result, the number of air-handling units was reduced from seven to four, freeing up space and reducing airhandling costs with a return on investment estimated at two years.
pathlengths, which result in higher sensitivity in readings of low absorbance samples. Additionally, the meter permits the selection of the size of the cuvette used in custom user methods from the available sizes. For all methods, the programmed cuvette size is displayed on the screen to assure that the proper pathlength is being used by the meter when calculating measurements.
System check
Upon turning on the meter, a performance check occurs to confirm that the light source is working properly and to calibrate the position of the grating. The grating calibration works by scanning for the ‘zero order’ light reflecting off the grating. If any mechanical problems are present, the meter will display an alert. This feature establishes confidence in measurements, knowing that the meter is always working properly without needing to run any additional tests.
ELEVATE YOUR MOISTURE ANALYSIS WITH THE NEXT GENERATION OF OHAUS MB SERIES
Sleek design offering improved durability and stability in performance, with an upgraded loadcell and carbon fibre heating technology
OHAUS Corporation, a leading worldwide manufacturer of weighing products, laboratory equipment and analytical instruments announced the release of the next generation of MB32, MB62 and MB92 Moisture Analysers. These new models represent a significant leap forward in moisture analysis technology, offering improved durability and stability in performance to meet the demands of modern laboratories and production floors.
Innovation in Effect
The next generation of MB Series features a sleek design and incorporates an upgraded load cell and carbon fibre heating technology, ensuring accurate and reliable results. The MB32 is ideal for routine moisture testing, providing consistent performance for everyday laboratory and production needs. The MB62 is versatile and suitable for a variety of moisture applications
across different industries. The MB92 is the more advanced option for users requiring a high level of performance and precision in moisture analysis.
Key features of the Next Generation of MB Series include:
• Sleek, modern design
• Upgraded loadcell for improved performance
• Carbon fiber heating technology for faster and more efficient heating
• Easy-to-use interface with intuitive controls
• Multiple connectivity options for data management
“We’re excited to introduce the next generation of MB Series Moisture Analysers,” said Adam Cui, Product Manager at OHAUS.
“With their enhanced durability and performance, these moisture analysers are designed to meet the evolving needs of our customers and provide reliable results for a wide range of applications.
Upkeep Leveled Up
Although advanced enough for the most important projects and durable enough for the heaviest workloads, the MB
Instrulab – a Division of Air & Vacuum Technologies (Pty) Ltd – are the sole agents for the Endecotts range of products for Southern Africa.
series remains simple to operate with their colour capacitive touchscreens, navigation knobs (easy to manipulate even when wearing protective gear), and LCDs with second line display. The MB92 features full glass panel and tool-free heating chamber assembly that also makes cleaning and maintenance just as easy and intuitive.
OHAUS Europe GmbH
Katarzyna Szołtyk-Szydło
Marketing Communication Manager
M (+48) 571 311 270
Katarzyna.Szoltyk@ohaus.com www.ohaus.com
MOISTURE ANALYSIS & EQUIPMENT
UNDERSTANDING AND ADDRESSING WATER ACTIVITY CHALLENGES WITH NOVASINA LABMASTER NEO
Water activity is a crucial measurement in various industries, impacting product quality, shelf life, and safety. As the largest component in compounds, pharmaceuticals, cosmetics, and foods, it plays a pivotal role in product stability and safety. In pharmaceutical compounding, controlling water activity is essential to extend
beyond-use dates and ensure patient safety. In food compounding, controlling water activity is necessary to prevent spoilage and ensure the stability of textures and flavours. Understanding and managing water activity can significantly enhance product stability and safety.
FFS VERIFIES MOISTURE WITH NEW METROHM ECO KARL FISCHER TITRATOR
Fuel Firing Services (FFS) was established in 1974 to provide specialist hydrocarbon waste recovery solutions in the petroleum sector. Ship slops, lubricating oils and other waste oils are received at production facilities across the country where specialised refining takes place.
Monitoring moisture content in used and refined oils is pivotal in guiding the refining process, and to certify final product conformance to required specifications. Thus, FFS Refiners relies on the Metrohm Eco Karl Fischer, which is ideal for determining moisture in a wide variety of materials.
FFS Refiners based their investment on the reliability, precision and service support offered by Metrohm.
The challenge of water activity
In the food industry, water activity is a vital parameter for maintaining product quality and extending shelf life. High water activity levels can promote the growth of bacteria, yeasts, and moulds, leading to premature spoilage, texture degradation, and loss of nutritional value. For instance, in muesli containing raisins, seeds and bran flakes, the moisture migration from raisins to bran flakes over
time results in dried-out raisins and soggy bran flakes.
In the pharmaceutical sector, water activity impacts the stability of proteins, enzymes, and biopharmaceutical components. It also affects hygroscopic excipients like starch and cellulose, which are sensitive to moisture, causing caking or clumping of powders. Issues such as API hydrolyses lead to efficacy and potential degradation of the drug. This degradation not only impacts the drug’s performance but also poses significant safety risks to patients.
Addressing water activity with Novasina LabMaster Neo
The LabMaster Neo by Novasina stands out as an advanced solution for measuring water activity. It provides accurate readings within 10 minutes, enabling production staff to control oven temperatures and conveyor speeds. It features contactless RFID salt standard identification, simplifying calibration and maintenance. The device has a comprehensive measurement range from 0.0300 to 1.0000aw and operates within a temperature range of 0-60°C. Hermetic Sealing Technology ensures
reliable measurements, preventing external factors from affecting results.
Practical applications
Food Industry: By controlling water activity to 0.85 or less in finished products, the growth of bacteria, yeasts, and moulds can be inhibited. This control is crucial for maintaining food safety and compliance with regulations such as 21 CFR Parts 108, 113, and 114.
Pharmaceuticals: The LabMaster Neo helps predict the stability of proteins and enzymes, manage the compatibility of hygroscopic excipients, and address issues related to API hydrolysis, crystallisation, and powder caking.
Cosmetics: Ensuring optimal water activity levels helps maintain the physical and chemical characteristics of solid dosage forms, contributing to product stability and efficacy.
EVA VOLUMETRIC KF TITRATOR
Where speed meets reliability
As a global leader in precision instruments, METTLER TOLEDO is dedicated to providing state-of-the-art instruments that drive accuracy, efficiency, and data security in laboratory workflows. The new EVA Karl Fischer volumetric titrator is a testament to this commitment of quality and innovation.
Fast & accurate water content determination
Offering the ideal combination of speed and reliability, the EVA volumetric Karl Fischer titrator is designed for accurate and efficient water content determination. It is available in two models to suit varying needs:
EVA V1 KF titrator: Optimised for rapid, precise water content determination in soluble samples, this model is ideal for routine testing with a focus on simplicity and efficiency
EVA V3 KF Titrator: Designed for more versatile applications, this model easily handles challenging samples, using homogeniser attachments and external sample extraction
High efficiency
The EVA Karl Fischer volumetric titrator features cutting-edge technology, including the advanced Fast Forecasting Amperometric (FFA) Algorithm, which ensures exceptional speed, reliability, and accuracy in water content analysis.
It is equipped with a high-resolution dDrive unit for precise titrant dispensing, and a rapid-response dSens M143 digital sensor to accurately detect changes in water content, delivering consistent, precise results across a wide range of sample types.
Simplify your lab routine with precision
Designed with user convenience in mind, the EVA Karl Fischer titrator features the intuitive OneClick interface, offering guided workflows, custom shortcuts, and PC-free operation for streamlined daily tasks.
The Smart Reader function allows for instant, error-free data transfer of reagent information, ensuring full traceability. Integration with LabX software allows users to achieve comprehensive data traceability that complies with ALCOA++ principles and regulatory standards, such as 21 CFR part 11, with enhanced user management, electronic signatures, and audit trails.
Precision for diverse applications
Ideal for industries such as pharmaceuticals, chemicals, and food and beverage, where speed and accuracy are critical, the EVA Karl Fischer volumetric titrator meets the highest standards of performance.
Advanced accessories
Elevate your analysis with specialised accessories, including thermostable vessels, homogeniser adapters, and drying ovens. These tools simplify handling challenging samples, ensuring precise results.
Customise your Karl Fischer process with options such as different burette sizes and extended terminal cables for added convenience and flexibility.
Keshnee Gounden and Aradhna Samuel, excited about their new Metrohm KF
Water Determination – Speed Meets Reliability for the Chemical Industry
Simplify your chemical analysis process and achieve fast, accurate, and reliable water content determination in your samples with the METTLER TOLEDO EVA Volumetric Karl Fischer Titrator. Whether you’re analyzing oil, solvent, paint, or any other chemicals, its advanced FFA™ control algorithm, fast-response digital sensor, and state-of-the-art dispensing technology deliver precision and efficiency every time. With its automatic sample detection and method start features, you can increase productivity and eliminate errors for more efficient analysis process.
www.mt.com/EVA-titration
Request
Tel: + 27 87 092 7300
e-mail: info@microsep.co.za www.microsep.co.za
MOISTURE ANALYSIS & EQUIPMENT
AMETEK BROOKFIELD
Computrac MAX4000XL moisture analyser
Increased precision, flexibility, and quicker test times - the Computrac MAX 4000XL provides reliable and accurate results up to 100 times faster than standard reference methods. The unique rapid cooling system increases throughput by 25%, improving your ability to monitor and adjust processes, maximise quality, and minimise waste. Its ease of use, versatility, and durability make the MAX 4000XL an ideal choice for manufacturing and laboratory environments alike.
Main features and benefits:
Rugged construction: Equipped with an allsteel enclosure and a durable nickel chromium heating element, the Computrac MAX 4000XL is designed to provide lab-quality data whether it is in the lab or on the production floor
• Rapid cooling system: The built-in lid fan quickly cools the heating chamber to reduce time between tests and increase overall throughput by 25%
• Versatility: The MAX 4000XL can test material up to 100 times faster than standard oven reference methods and is ideal for everything from plastics and pharmaceuticals to foods, chemicals, and more
• Flexible ending criteria: User-adjustable ending criteria and pass/fail criteria help to optimise test results and performance for your unique application
• Multistage testing: Several tests can be linked to form a single, multistage test that can change temperatures, ending criteria, and times between each test segment
• Real-time results: The MAX 4000XL offers simple, menu-driven operation and a userprogrammable interface with a keypad and large colour display that allows users to view real-time moisture curve and rate-ofmoisture-loss graphs during testing
• Web server: An optional web server allows users to download calibration reports, view the LCD screen, download the audit log, and upload and download test programs, results, and graphs
• Data storage: Can store up to 250 test programs and retains the last 1 000 test results and last 100 test graphs
Accurate moisture analysis is essential for maintaining product quality and optimising production, particularly in industries like pharmaceuticals, food, and chemicals. Additionally, certain products must comply with legal moisture content limits set by national regulations, especially in the food sector.
METTLER TOLEDO offers a comprehensive suite of moisture analysers, methods, and tools for rapid and precise moisture content measurements, powered by advanced weighing technology and precise temperature control.
High performance and accurate results
Compared to traditional loss-on-drying techniques, METTLER TOLEDO’s highperformance moisture analysers provide a faster and more efficient method for determining moisture content. Featuring rapid halogen heating, exceptional weighing accuracy, and the ability to measure moisture content down to 0.01%, these analysers ensure reliable, repeatable results for any sample type, and fulfill compliance requirements. Integrated support for method development further enhances precision and consistency.
Versatile, intuitive and user-friendly
The user-friendly touchscreen interface and guided operation simplify moisture content determination for a wide range of samples. Their compact and robust design ensures durability, even in harsh conditions, making them ideal for laboratory and production settings. Additionally, the flat stainless surfaces allow for easy cleaning, ensuring long-term reliability.
Data management & process control
Key features include compliance with ALCOA+
OMNIS KF TITRATORS FROM METROHM
OMNIS KF titrators are the high-end volumetric and coulometric Karl Fischer titrators based on the modular OMNIS platform. With OMNIS KF titrators, determining water in samples has never been more convenient, safer and easier.
Features:
• Unprecedented ease-of-use and minimal manual workload
Faster and more reliable results with various automation possibilities
• Avoid contact with reagents thanks to the modern Liquid Adapter (for volumetric KF titration)
• Flexibility to upgrade your system as needed thanks to the modular approach
• Compliance with FDA Regulation 21 CFR Part 11 and EudraLex, Volume 4, Annex 11
Automations aspects:
OMNIS KF titrators offer many automation options, allowing you to minimise timeconsuming manual work:
• Once you have injected the sample, the titration is started automatically After measurement, the used sample is discarded automatically
The cell is prepared for the next determination automatically
Automation also means that all samples are treated identically, which improves reproducibility and result accuracy, and allows you to streamline work in your lab and achieve the following:
Faster sample preparation: save up to 25% of your time using OMNIS KF DisCover
• Higher throughput: with just one additional workstation for parallel analyses, you will save up to 40% of the time compared with sequential determinations
principles, automated export and printing capabilities, user password protection and autolock functionality. Customisable home screens minimise errors and enhance process safety and operational efficiency, streamlining workflow.
Fast instrument performance verification
SmartCal is a unique test substance designed for a quick, 10-minute performance validation of your moisture analyser. Regular testing with SmartCal provides documented records of instrument performance, enabling early detection of any operational deviations and trusted moisture determination results.
MICROSEP (PTY) LTD
Elisha Ramlal
Tel: 087 092 7300
elisha.ramlal@microsep.co.za www.microsep.co.za
Decreased solvent use: with the OMNIS Sample Robot, you only need 12mL of solvent per sample
OMNIS platform: More than just KF titrations
Would you like to expand your OMNIS KF system with a NIR spectrometer or automation? No problem!
OMNIS is a universal platform that allows you to integrate KF titrators, potentiometric titrators, NIR spectrometers, and automation options of the OMNIS brand in one system, controlled by just one software.
Thermo Scientific™ Niton™ XL5 Plus handheld XRF Analyzer
BIOLOGICAL TESTING & BIOTECHNOLOGY
CHEMICAL EXTRACTIONS AND BIOLOGICAL TESTING
The Mixer Mill MM 400 is a truly multipurpose mill designed for dry, wet and cryogenic grinding of small volumes up to 2 x 20ml. It mixes and homogenises powders and suspensions with a frequency of 30Hz within seconds; it is unbeatably fast and easy to operate.
The compact benchtop unit is suitable for classic homogenisation processes, as well as for biological cell disruption for DNA/RNA and protein extraction. Long processing times up to 99 hours make the MM400 ideally suited for research applications, for example in mechanochemistry.
Regarding performance and flexibility of this mill, there is no equivalent technology available on the market.
The MM 400 is the first laboratory mill that can be calibrated. RETSCH initially calibrates time and frequency of the mill and offers a regular calibration service to ensure reproducible milling processes.
Mixer mills are frequently used for homogenising biological samples.
The so-called bead beating with small glass beads is an established method for cell disruption of yeasts, microalgae and bacteria. The sample is only moderately warmed in the process, which can be reduced to a minimum by pre-cooling.
The MM 400 allows for efficient cell disruption of up to 240ml cell suspension for DNA/RNA and protein extraction. For accurate diagnosis of infections, it is possible to isolate intact bacteria from tissue in 8 x 30ml bottles or 10 x 5ml vials by using adapters.
For the pulverisation of 25 to 30g plant material, such as cannabis flower, conical centrifuge tubes are best suited. Up to eight tissue samples, such as fresh liver in buffer solution, can also be homogenised in these 50ml tubes using steel or zirconium oxide balls.
To keep the mechanical stress on the vials as low as possible, a reduced frequency and a high filling level, e.g. with buffer and sample, is recommended.
ENSURE EXPERT FILTRATION OF YOUR SAMPLES
National Separations offers a wide selection of syringe filters designed to achieve efficient and rapid filtration of both organic and aqueous solutions. Syringe filters provide
accurate and reliable sample preparation in various laboratory applications, including pharmaceutical, biotechnology, agricultural, food and beverage, and environmental labs.
High-quality membranes
Syringe filters feature a range of highquality membranes with different pore sizes and diameters. Designed for consistency and reliability, these filters ensure quick and easy sample preparation, offering maximum convenience.
Variety of membrane materials
Syringe filters are available in different membrane formats. Options include hydrophilic, hydrophobic, solvent-resistant, or pre-filter combinations, available in both sterile or non-sterile versions. High-grade membrane materials include regenerated cellulose (RC), polyvinylidene fluoride (PVDF), nylon membranes (NY), polyethersulphone (PES), cellulose acetate (CA), polytetrafluoroethylene (PTFE) and polypropylene (PP). Each material offers unique chemical compatibility, making them suitable for specific applications.
Versatile and efficient
Syringe filters are designed to have low adsorption of analytes, ensuring maximum recovery of the filtered product. Filters provide excellent flow rates and low hold-up volumes, optimising filtration efficiency and minimising waste. Additionally, syringe filters fit on all standard luer lock syringes, preventing any leakage during the filtration process. Each syringe filter is clearly labelled with details such as pore size, membrane type, and batch number for easy identification and traceability. The choice of filter diameter is determined by the sample volume and the nature of the particles being filtered.
SANGER DNA SEQUENCING SERVICE LAUNCH AT INQABA BIOTEC EAST AFRICA
“Sanger sequencing is the gold standard in DNA sequencing.” Come sequence at Inqaba Biotec East Africa Ltd, our new molecular biology lab facility based at 74 Riverside Drive, Westlands. Victoria Office Suites, Unit 7, Nairobi, Kenya.
Sanger sequencing is a cost-efficient method ideal for sequencing small stretches of DNA. We offer a range of Sanger sequencing services with flexible options to meet your project requirements, and our experts are available to assist as needed. Use our fully newly equipped lab and expert staff as an extension of your team. We also offer sequence data and variant analysis solutions. At the IBEA lab, we offer DNA extraction services, PCR, and post-PCR applications like gel electrophoresis and sanger sequencing.
Basic service - A purified PCR product/ high-quality plasmid DNA and primers are provided to Inqaba biotec at the correct concentrations. Inqaba biotec performs sequencing reaction, purification and injection on the ABI 3500XL Genetic Analyser.
BIOLOGICAL TESTING & BIOTECHNOLOGY
NUZAR HIGH-QUALITY PURE WATER SYSTEMS
Testing of biological high-quality pure water is an important aspect in laboratories for many applications. Even minute traces of impurities or contaminants can compromise the accuracy and reliability of experimental data. RephiLe’s NuZar water systems are specifically designed to consistently produce high-quality water that meets the stringent demands of scientific applications, ensuring operational efficiency while remaining cost-effective.
Reliable water quality
Incorporating state-of-the-art water purification technologies and optimised flow paths, the NuZar water systems guarantee exceptional water quality. Comprehensive process control management, coupled with continuous water purity monitoring at each purification step, ensures consistent water quality and reliable system performance.
Compact and powerful
The NuZar water systems are powerful, smart and compact, with a small footprint. These systems deliver consistently highquality water, ensuring effortless operation, user-friendly monitoring, and cost-effective maintenance for laboratory users.
Elegant features
NuZar systems provide a straightforward plug-and-play installation process. An ergonomic dispenser with an intuitive
colour touchscreen display ensures easy operation. A unique and elegant feature is the easy-to-remove consumable access cover, which clips on with a light touch. Cartridges incorporate an optimised flow design to improve water quality stability and the efficiency of polishing resins. Two dispenser heights offer flexibility, and the tank sanitation module comes equipped with a pre-installed mercury-free germicidal UV lamp. RFID tracking and data traceability of consumables contribute to enhanced management capabilities.
Water quality compliance
Depending on the application, several models are available to provide either ultrapure water, EDI/DI water, pure water, RO water, or clinical-grade water, that meet or exceed ASTM, CLSI, CAP and ISO Type I or Type II water standards, and complies with the Purified Water requirements outlined in the European and US Pharmacopoeia.
NuZar Lite systems
The NuZar Lite systems are a unique addition to RephiLe's water purification portfolio, designed to meet your pure water needs while also saving valuable lab space. Ready to use straight out of the box, the NuZar Lite system offers easy installation and setup with a simplified, user-friendly design, ensuring smooth operation even for users with minimal experience. By streamlining workflows, the NuZar Lite series enhances both the quality and productivity of laboratory processes.
ENHANCE BIOLOGICAL SAMPLE TESTING WITH MILESTONE SAMPLE PREPARATION
Testing of biological samples such as animal tissues for research or in contract testing labs is an important area of analytical measurement. As metals testing moves from traditional GFAA to ICP-MS, today’s biological testing labs are able to measure more analytes at lower levels than ever before. In today’s competitive environment, the high throughput of ICP-MS demands increased efficiency and productivity in sample prep.
GRANT CONTROLLED RATE FREEZE THAW (CRFT)
Liquid nitrogen and cryogen free controlled rate freeze and thaw system for cryopreservation
The CRFT system has been developed to minimise and reduce the risk of contamination and designed for use in cleanrooms and barrier facilities. Its performance of cell viability after freezing and thawing is equal to, if not more
advanced than, comparable systems. As alcohol is not used, there is also a greatly reduced fire risk. Its performance of cell viability after freezing is equal if not more advanced to comparable liquid nitrogen freezers. The freezing and thawing rate is precisely controlled, ensuring accuracy and reproducibility throughout the freezing and thawing profiles, especially for the important nucleation/seeding phase. This provides optimal recovery of cells on thawing. Operation is simple and can be carried out with or without a PC; data can be logged via PC software and profiles are directly displayed on PC screen. Different freezing profiles are available from a dropdown menu and customised profiles can be designed through the software editing suite.
Features and benefits of the Controlled Rate Freeze Thaw
• Accurate and reproducible control of cooling rates and sample temperatures
• Interchangeable heads
• Controlled thawing system
Easy to use and samples can be nucleated/seeded in-situ
• Linear and non-linear cooling profiles
Low running costs: estimated at 1% of liquid nitrogen-controlled rate freezing
• Temperature remains at -100 °C at the end of cycle for straw applications until freezer is switched off
• Uninterruptible Power Supply (UPS): complete cycle run if power fails (supplied as an optional accessory) CE marked (laboratory use)
• Servicing and calibration available
• Runs on a 24V supply Two-year warranty
Milestone understands the challenges faced by biological testing labs and strives to develop instruments that improve analytical data quality, while helping labs become more efficient and productive. Our products are extremely easy to use, built to the highest quality and safety specifications to give many years of excellent service, and low lifetime operating costs. High reliability, fast, responsive service, and great applications support ensures extremely high uptime and a great ownership experience.
Corrosion Science Research Laboratory/ Group (CorroSci) has recently acquired the BioLogic SP200 PGSTAT to add onto the already existing catalogue of BioLogic instruments. CorroSci is a research group that is attached to the Department of Chemistry in the Faculty of Science, Engineering and Agriculture at the University of Venda (UNIVEN) in South Africa.
The research group is led by Professor LC Murulana. CorroSci focuses on the corrosion of materials in corrosive environments.
The broad aim of CorroSci is to investigate the corrosion inhibition of various materials by making use of various corrosion inhibitors. In order to achieve this aim, the researchers in this group make use of various techniques, such as weight loss, electrochemical measurements, spectroscopic methods, microscopic methods, and quantum chemical calculations.
Since its inception, the CorroSci has made tremendous discoveries and contributions into the body of knowledge in the corrosion science field.
CorroSci researchers and postgraduate students:
From left to right (sitting): Kemelo Moloto, Fulufhelo Tshikhudo and Sihle Nyembe.
From left to right (standing, wearing white coats): Gift Masuku, Uhone Mudau and Mbali Nkosi.
From left to right (standing, wearing blue coats): Rendani Tshithavhani, Prof LC Murulana and Rinae Ratshikombo.
RAMAN SPECTROSCOPY
The easy way to analyse polymers
Plastics can be divisive since they are convenient and inexpensive yet have a harmful impact on the environment. These materials are found everywhere – from museums to modern medicine, and even in the ocean waves. Plastic is ubiquitous, and Raman spectroscopy can be used anywhere it is located for identification, classification, and quality testing purposes.
Raman spectroscopy is increasingly chosen for polymer analysis because it is nondestructive, requires no sample preparation, and gives results in just seconds. It is easy on the user; even non-technical operators can collect data on-site. Raman is also environmentally friendly – requiring no chemicals, solvents, or materials for sample prep – and it does not generate any waste.
Learn more about the fundamentals of Raman spectroscopy in our blog article.
Corrosion inhibitors from some selected compounds and plant extracts, such as ionic liquids, quinoxaline derivatives, flavonoids derivatives, thiazolidinediones, synthesized carboxylic acids and amino esters, pyrazole derivatives, sulphonamides, sulphonyl amides derivatives, Lippia javanica, Helichrysum kraussii, and others have been successfully reported as excellent for mild steel, aluminium, zinc and copper metals in various acids and bases.
The BioLogic SP200 PGSTAT will be used for the electrochemical investigations that are fundamental to the understanding of basic corrosion inhibition mechanisms.
The new range of pyridine-free reagents for reliable Karl Fischer titration
On many occasions it is essential to know the amount of water present in a sample. Water can influence the reactivity, stability, and shelf life, etc, of products. Karl Fischer titration has been the globally accepted method for the determination of water since the beginning of the 20th century. It is based on the Bunsen reaction, a fast, two-phase reaction, with a stoichiometric relationship between the I2 consumed and the amount of water in the sample.
The first KF reagents developed contained pyridine in their formulation, supposedly essential for the reaction, but later experiments showed that pyridine only acts as a buffer substance and could be replaced by other basic compounds capable of carrying out the same function. For this reason, the new Karl Fischer Aquagent reagents contain imidazoles instead of pyridine, alternative bases with good buffering capacity that allow stable titration end points to be quickly obtained. Aquagent is the Scharlau name given to a wide range of Karl Fischer titration reagents. The newly developed manufacturing and control method allows us to launch a new Aquagent with multiple advantages for the user, listed below. We offer a wide, improved range of reagents for sample titration with reliable results, which satisfy the needs of modern-day laboratories in the determination of water using Karl Fischer.
New Aquagent advantages:
• More stable and robust factor
Faster initial stabilisation
• Greater reaction speed
• More stable endpoint
• Greater homogeneity between batches and within the same batch
• Suitable for a wide variety of matrices
• Greater variety of formats Less environmental impact
METTLER TOLEDO’S XPR Automatic Balance sets a new benchmark for automated weighing, delivering unparalleled accuracy in dispensing both powders and liquids into a variety of container types. The XPR automatic balance is the ideal solution for labs seeking to improve accuracy, safety, and productivity in their weighing and dispensing operations. With the ability to dispense at a USP minimum weight of 4mg, it far surpasses the precision achievable with manual methods. Automatic dispensing increases user safety, saves time, and minimises waste of expensive and rare substances.
Precise and efficient
The XPR automatic balance delivers precise, efficient and consistent weighing processes. It serves as a versatile standalone, all-in-one solution for basic weighing, powder dispensing and liquid dispensing. This consolidated approach makes it suitable for a wide range of industries, including both pharmaceutical and non-pharmaceutical industries, where applications such as quality control, sample and standard preparation, capsule filling and formulation screening play an integral role.
Advantages of automated weighing
By combining automated dispensing with advanced weighing technology, the XPR automatic balance reduces out-ofspecification (OSS) errors by up to 50%,
significantly cutting down on costly reworking. Weighing small amounts of substance is now considerably faster, as automated dispensing reduces the minimum sample weight by up to 30%.
Save costs by using less of your expensive or rare samples.
Easy to operate
Operating the XPR automatic balance is user-friendly and requires no special training.
Automated dispensing protects the operator from potential exposure to toxic or chemically aggressive substances,
enhancing workplace safety while maintaining precise control over the dispensing process.
Precise concentrations
Equipped with a liquid dispensing module, the XPR automatic balance enables you to prepare highly precise concentrations, as low as 0.1mg/g, in a single step. The balance calculates the exact solvent quantity needed based on the dosed substance, delivering fast, accurate and cost-effective results.
Increased productivity and throughput
For even greater productivity, simply add a sample changer to the XPR automatic balance to dispense solids and liquids into up to 30 containers in a single automated run. Connect the XPR automatic balance to LabX software for comprehensive data management and user-friendly guidance, further enhancing process efficiency.
ALLIANCE iS BIO HPLC SYSTEM: INTUITIVE SIMPLICITY FOR BIOPHARMA
The Waters Alliance iS Bio High Performance Liquid Chromatography (HPLC) System introduces new capabilities to address the operational and analytical challenges of biopharma quality control (QC) laboratories. The new HPLC system combines advanced bio-separation technology and built-in instrument intelligence features. It is designed to help biopharma QC analysts boost efficiency and reduce up to 40% of common errors, saving time lost by investigating the source of failed runs and out-of-specification results.
MaxPeak Performance Surface (HPS) Technology
The bio-inert design of the instrument features Waters MaxPeak High Performance Surface (HPS) Technology applied to key internal components including the system flow path, to minimise unwanted interactions from metal-adsorbing analytes. The system pairs with Waters QuanRecovery™ Vials and Plates, as well as MaxPeak Premier HPLC Columns equipped with eConnect™ Column Tag Technology, allowing for more confident platform methods that eliminate the need for lengthy column conditioning and method development.
Streamlined data management and compliance
The Alliance iS Bio HPLC System also combines with Waters complianceready Empower Chromatography
Software to help laboratories collect, manage, and report chromatography test results. It integrates seamlessly with both Waters and third-party liquid chromatography instruments, helping high-volume QC labs mitigate operational risks, prevent disruptions, and increase overall productivity.
Simplifying biologics QC analysis
This next-generation HPLC system delivers a new level of simplicity and instrument intelligence to biologics QC analyses, enabling laboratories to meet quality standards, ensure compliance and achieve on-time product delivery goals. The Alliance iS Bio HPLC System sets a new standard for performance and efficiency in biopharma QC labs.
ENDECOTTS - THE GLOBAL LEADER IN PARTICLE SIZE ANALYSIS
Air & Vacuum Technologies proudly represents Endecotts, the global leader in particle size analysis
Known for their meticulous manufacturing and stringent quality control, Endecotts test sieves and shakers are crafted from the finest materials to meet the diverse needs of various industries.
Choosing Endecotts test sieves can lead to significant time- and cost-savings with their:
• Efficiency: With their precision and accuracy, Endecotts test sieves minimise the need for retesting, saving both time and resources
• Versatility: The wide range of sizes available ensures users can select the exact sieve needed for the application, avoiding unnecessary equipment costs
• Durability: Made from high-quality materials and built to last, Endecotts test sieves reduce the need for frequent replacements, saving money in the long run
Designed to meet the modern laboratory’s needs, Endecotts test sieve shakers come in various models to cater to different requirements, ensuring efficient and accurate particle size analysis.
Key features:
• Ergonomic design: Easy to use and seamlessly fit into laboratory workflows
• Versatility: Suitable for a wide range of applications, from routine quality control
to research and development
• Durability: Built with high-quality materials for robust construction and long-lasting use
Endecott’s test sieve shakers and sieves are trusted worldwide across industries such as: Mining
• Manufacturing
• Chemical and Pharmaceutical Industries Geological and Environmental Studies
• Engineering and Construction
• Agriculture
INSTRULAB A DIVISION OF AIR & VACUUM TECHNOLOGIES (PTY) LTD
Sun Pharmaceutical Industries Ltd (Sun Pharma) is the fourth largest specialty generic pharmaceutical company in the world with 43 manufacturing facilities worldwide. They provide high-quality, affordable medicines that are trusted by healthcare professionals and patients alike in more than 100 countries.
As a user of a wide variety of raw materials, the company recently invested in the Metrohm Mira P for rapid raw material identification (RMID). The beauty of the Mira P lies in the fact that it can be used to identify raw materials without opening the bag or container, thereby ensuring results within seconds.
This speeds up quality control testing to release raw materials just-in-time (JIT) for use in production. The Mira P is small, mobile and lightweight with a user-friendly interface, making it very easy to use by raw material samplers and analysts in the goods-receiving area.
VIEW AND MEASURE PARTICLES IN-SITU AND IN REAL-TIME
METTLER TOLEDO’s EasyViewer is an advanced probe-based imaging tool that captures highresolution images of crystals, particles and droplets, as they exist in-process. Combined with iC Vision, an easy-to-use image analysis software, EasyViewer becomes a powerful particle size analyser that can monitor process changes and quantify particle size and shape in-situ and in real-time.
Powerful image analysis
EasyViewer provides an immediate understanding of particles as they naturally exist in-process with sub-micron resolution. EasyViewer’s turbidity trend is highly sensitive to system changes, and real-time image analysis measures particle size to track growth and shape changes that are impossible with offline techniques.
New experimental insights
By employing image analysis-based particle size measurements, EasyViewer provides a rapid and early understanding of how particles and droplets change. Everyone can capture outstanding microscope quality images of particles in-situ to obtain a better understanding of complex process systems. Explore crystals, particles and droplets with exceptional precision and detail, without the need for sampling or dilution.
Convert images to high-quality data
The Image2Chords module simplifies particle process development by providing an easy-touse platform for simultaneous imaging and chord length distribution (CLD). Image2Chords converts images into high-quality CLD data, trends, and statistics that are used to confidently characterise particle mechanisms, including nucleation, growth, dissolution, breakage, and morphology changes. This
capability enables scientists to gain real-time process insights from every experiment using a single in-situ probe, facilitating quicker and more informed decision-making, faster than ever before.
Confident deployment
EasyViewer and iC Vision software allow one to leverage auto-focus, auto-lighting, and autosave the best image algorithms. Capture crisp,
high-resolution images ensuring confidence and data quality, even when working remotely. Advanced image analysis automatically detects unexpected events. This allows scientists to quickly adjust parameters to avoid conditions that lead to downstream impurities, filtration problems or scale-up risks. With the assistance of experimental images, data analysis is immediate, intuitive and conclusive. Once the process is well understood at a small scale, the choice of probes enables confident scale-up from 10mL to pilot scale.
Flexibility for scale-up
The small, probe-only instrument design and flexible mounting system can be inserted into reactors, pilot vessels and pipelines. This allows for a comparison of results obtained at smaller scales with those from the scale-up process, thereby reducing risks in late-stage development.
Faithful Mkhonza (Sun Pharma raw material analyst) gets acquainted with her Mira P supplied by Romola Issari (Metrohm)
EasyViewer PVM® Particle Size Analyzer
• New Experimental Insights. Capture high-resolution images of particles as they exist in-situ and in real-time.
• Powerful Image Analysis. Combined with iC Vision™ software, EasyViewer is an advanced particle size analyzer that can monitor process changes, and quantify particle size and shape in-process, without sampling or dilution.
• Convert images to high quality data. The Image2Chords™ module provides simultaneous imaging and chord length distribution (CLD).
• Flexibility for Scale-Up. Reduce risk at late-stage process development. Measure Particles In-Situ and in Real-Time
Tel: + 27 87 092 7300
e-mail: info@microsep.co.za www.microsep.co.za
LIFE SCIENCES
INTRODUCING THE ULTRASONIC HIGHTHROUGHPUT SAMPLE PREPARATION
Heilscher Ultrasonics specialises in highperformance ultrasonic homogenisers designed for lab, bench-top, and production-level applications. Hielscher Ultrasonics is a leading innovator in the development, manufacturing, and distribution of high-performance sonicators, designed for a wide range of liquid applications.
Our non-contact sonicators are essential
tools in sample preparation, analysis, and diagnostics, offering unparalleled efficiency in the sonication of multiple samples within tubes, 96-well plates, multi-well plates, PCR plates, and Petri dishes. Common applications of our sonicators include cell lysis, nucleic acid extraction, protein isolation, DNA & RNA fragmentation, cell solubilisation, and sample homogenisation. Now available at inqaba biotec.
SMARTCHECK FOR PIPETTE VERIFICATION
Rainin’s SmartCheck is a quick and easy way to check if pipettes are dispensing accurately. SmartCheck has a proprietary technology consisting of a weighing cell that automatically recognises the test volume. Based on four replicates, the device provides a quick, reliable confirmation showing if the pipette and its user deliver accurate volumes.
Pipette verification in seconds
Verifying a pipette's performance before working with precious samples and reagents saves time and money, especially in regulated environments. SmartCheck runs a number of calculations and delivers a pass or fail result in less than 60 seconds, then you know your pipette is aspirating and dispensing correctly.
Verify any brand of pipette
Use SmartCheck to verify the performance of any brand of pipette that dispenses volumes between 10-1000μL. Users can also verify individual
channels of multichannel pipettes. Simply dispense deionised water into the liquid chamber and SmartCheck automatically detects the test volume and delivers a result. It is also perfect for training and improving pipetting technique.
Fast & compact
Not only is SmartCheck fast and compact, it is the only automatic ISO 8655-based pipette verification tool available. SmartCheck takes volumetric measurements, using the gravimetric method, and calculates the random and systematic error based on four measurements.
NATIONAL
Frances
Frances.Renwick@natsep.co.za www.natsep.co.za
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LIFE SCIENCES/ COMPANY LISTINGS
LABORATORY COMPLIANCE IN THE PHARMA & LIFE SCIENCES INDUSTRIES
In the highly regulated fields of biotechnology and pharmaceutical manufacturing, maintaining Good Laboratory Practice (GLP) and GxP compliance is paramount. These guidelines ensure the quality and integrity of laboratory data, which is crucial for maintaining trust and credibility.
This article explores the core elements of GxP compliance and highlights various laboratory equipment and solutions from Labotec that support these guidelines.
Core elements of GxP compliance
GxP compliance revolves around traceability, accountability, and data integrity. Laboratories must ensure thorough documentation, staff training, consistent procedures, and equipment validation to meet these standards. Compliance with GLP and GxP guidelines is not just a regulatory requirement but a cornerstone of quality assurance in laboratory operations.
Laboratory equipment and solutions
To complement GLP and GxP guidelines, laboratories need to invest in specialised equipment and solutions.
Key equipment needs include:
• Routine monitoring and validation equipment ensures that laboratory conditions and processes remain within specified parameters
• Incubators and stability testing equipment are essential for maintaining controlled environments for sample storage and testing
• Sample and glass-handling equipment facilitates the safe and efficient handling of samples and glassware
• Liquid-handling solutions automate the precise dispensing of liquids, reducing the risk of contamination and error
• Laminar flow benches provide a sterile environment for sensitive laboratory procedures
Analysis equipment includes a range of instruments for various analytical techniques, ensuring accurate and reliable results.
Importance of IQ/OQ documentation and certification
Installation Qualification (IQ) and Operational Qualification (OQ) documentation and certification are critical for laboratory equipment. These processes ensure that equipment is installed correctly, and functions as intended, which is essential for maintaining compliance with GLP and GxP guidelines. Laboratories must stay up to date with the latest technologies and guidelines to ensure ongoing compliance.
Labotec: a comprehensive solutions provider
Labotec is a leading provider of laboratory equipment and services for the pharmaceutical, biotechnology, and research industries. Its catalogue includes a wide range of products from well-known, global suppliers. These products can be used for the following applications:
• Melting point analysis
• Nitrogen determination NIR spectroscopy
• Laser particle sizing
• Microscopy Rotary evaporation
• Soxhlet extraction
• Parallel evaporation Flash and preparative chromatography
• Freeze drying
• Spray drying
• Electrospray
Labotec also emphasises the importance of IQ/OQ for ensuring equipment is properly installed and functioning as intended. Its expertise in process development allows the business to provide valuable advice and support to customers. Additionally, Labotec offers a range of services, including laboratory-scale production of nanofiberbased biomedical and pharmaceutical products.
Maintaining GLP and GxP compliance is essential for laboratories in the pharmaceutical and life sciences industries. By investing in the right equipment and staying updated with the latest technologies and guidelines, laboratories can ensure the highest standards of quality and integrity. Labotec stands out as a comprehensive solutions provider, offering a wide range of equipment and services to support the development and production of high-quality products.
INSTRULAB a division of Air and Vacuum Technologies (Pty) Ltd
• Advion - Compact & affordable High Performance Mass Spectrometer using Atmospheric Solid Analysis Probe, Open Port Sampling Interface and Gas Phase Sample Analysis. Other instrumentation includes Plate Express (TLC interface), (U)HPLC, ICP-MS and Chip-Based Electrospray Ionization
• Interchim – Formidable instrumentation for Preparative Liquid Chromatography, Ultra performance Flash Purification, Purification of Proteins and Peptides, Process Purification and Protein Analysis.
• Bio-Logic - High performance instrumentation for the Research Lab, Electrochemistry, Potentiostat/Galvanostat, Corrosion, Battery & Fuel Cell Testing, Super Capacitors, Sensor Development, Nanotechnology, Material Testing, Solar Cells & Photovoltaic Systems, Electro-chemical Scanning Systems, Spectroscopy & Photosynthesis and Rapid Kinetics.
• CAMAG – World’s Leader in Thin Layer Chromatography supporting TLC, HPTLC, HPTLC PRO and Dried Blood Spot Sampling.
• Kuhner - World’s most reliable Shaker/Shaking Incubator (from 2g up to 2tons) for more than 60 years with 5 years warranty Tel: (011) 804 3503 Fax:
Your accredited service provider for: - Calibration - Validation & Qualification - Technical Inspection
ISO/IEC 17025:2017
Official agent for: www.labcalsolutions.com
T: +27 11 466 4145 E: admin@labcal.co.za
We provide innovative technology for your most challenging samples, including instruments for analytical, separation, and metallographic science as well as complete line of consumable products.
Tel: +27 11 974 1681
Fax: +27 11 974 1848
Cell: +27 82 771 7083 www.lecoafrica.co.za
Head office Tel: 011 615 6076
Durban Tel: 031 701 2711
Cape Town Tel: 021 946 1722
Eastern Cape Tel: 041 450 5685
Export: +27 (0)72 910 5749
Website: www.hanna.co.za
E-mail: hanna@hanna.co.za
Your solution provider of certified and analytical reference materials, pharmaceutical impurity - and drug standards, biological standards, profieciency testing schemes and Fusion Equipment
PROVIDING WINNING SCIENCE, TECHNOLOGY, HEALTH AND EDUCATION SOLUTIONS ACROSS AFRICA
Our extensive sourcing network and long-term partnerships with leading international manufacturers means you can get the highest quality product at the most competitive price.
agents for: CEM Microwave and Teledyne Cetac Technologies Radom MICAP-OES
Microsep distributes and supports market-leading brands in southern Africa and sub-Saharan Africa. We offer the sale and support of technologically advanced scientific and analytical instrumentation, laboratory and industrial weighing equipment. Our focus is to provide high quality products and innovative solutions to satisfy the needs of our customers in the general laboratory, pharmaceutical, biotechnology, food and beverage, chemical and petro-chemical, environmental and industrial markets. Industry leading brands include Waters and Mettler Toledo.
2 Saturn Crescent, Linbro Business Park Frankenwald Ext. 30 Sandton, 2090
We are a BBBEE subsidiary of Metrohm-AG. Our market-leading products are produced in Switzerland and other European countries thereby guaranteeing you the highest accuracy and reliability. We supply lab and on-line process monitoring analysers for:
pH, conductivity, dissolved oxygen, Titration / Karl Fischer, Ion chromatography, Electrochemistry, Raman and NIR spectroscopy. Milestone: microwave sample preparation, acid purification systems and direct mercury analysers.
Gauteng: 011 656 1918
Kwazulu Natal: 031 265 0067
Western Cape: 021 852 0213 E-mail: info@metrohm.co.za www.metrohm.com/en_za
National Separations (NATSEP) partners with global leading biotechnology and diagnostic companies to provide general laboratory equipment, lab and process filtration technologies, water purification systems, rapid microbiological and contamination monitoring products in southern Africa and sub-Saharan Africa. Market leading product brands include Amazon Filters, Hygiena Diagnostics, Rephile BioScience, Saint-Gobain and Avantor Bioprocess for all industries. Sartorius products for the Food and Beverage market.
With multiple flow rate models of nitrogen, hydrogen and zero air laboratory gas generators, Peak Scientific has the ideal gas solution for LC-MS, GC & GC-MS instruments, even up to an entire laboratory’s gas supply.
Streamline your workflow with a cost e ective, reliable, eco-friendly and safe alternative to gas bottles.
SSS is a highly specialised company dedicated to offering superior support in niche markets in Chromatography and related disciplines. SSS is an OEM distributor for Vici and an accredited distributor for all Varian consumables; Vici Valves and GC Detectors; Precision Sampling Syringes; ChromPerfect Data Systems; Hamilton Syringes; SGE Syringes & Supplies; National Scientific Vials, Septa, Syringe Filters, Caps etc; Bohlender Teflon Products; GL Science Leak Detectors; Specialised and Refurbished Instruments; Capillary Columns; Solid Phase Extraction; Nikepal Syringes. Training is a priority at SSS and regular hands-on courses are offered. The range is expanding annually and SSS also manufactures specialised Inlet Systems for sample introduction of
BUYER’S GUIDE
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