PHARMACEUTICALS
Formulation for Biopharmaceutical Applications Formulation is helpful in a wide variety of industries and settings. To name just a few, these include pharmaceutical laboratories, research and development laboratories, new product development (such as cosmetics and hair dyes), food production, beer brewing and much more. Smaller laboratories may rely on handwritten records to retain formulas, noting ingredients, weights and other properties. Transcription errors or even poor handwriting may cause incorrect values to be recorded, resulting in unusable materials and wasted time. A balance that stores formulations, or even connecting the weighing device to a PC with LIMS software, greatly reduces the risk of error, as well as provides documentation and traceability. Our Solis range of semi-micro, analytical and precision balances offer formulation, data communication and percentage weighing that simplify scaling and quality control. Solis balances can store up to 99 ingredients for complex compounds. In addition to single formulation, users can store custom formulas
and recipes in the balance’s database to conveniently retrieve them when needed. The high-resolution graphic display clearly shows results and menu prompts to intuitively guide users through the many functions available on the Solis, including formulation. When formulas are measured and stored, they can be sent to computers, printers and LIMS via the Solis’ RS-232 interface for GLPcompliant printouts and exports. To help with repetitive measuring tasks, Solis balances feature check-weighing with an audible alarm so users can simply load compounds until the balance beeps. To learn more about how Solis balances can help you with formulation tasks, visit https:// www.adamequipment.com/solis-semi-microand-analytical-balances ADAM EQUIPMENT Audrey Mora Tel: +203 709 4774 ext.313 a.mora@adamequipment.com www.adamequipment.com
Mira P for the pharmaceutical industry Instant onsite verification of raw materials Metrohm is pleased to present the latest compliant handheld Raman solution for the pharmaceutical industry. Mira P offers enhanced resolution, new immersion sampling and validation accessories, and ergonomic features that improve user experience. Mira P is fast, easy and accurate, helping users optimise the inspection of incoming goods, formulation verification, and process monitoring. Mira P and its dedicated software, MiraCal P, was developed in collaboration with some of the world’s leading pharmaceutical companies. New features streamline verification routines and include an automated training set builder and improved model analysis tools. Soft- and firmware improvements, like a colour-coded audit trail with advanced management features, ensure that users can easily reference samples even in massive
databases. FDA compliance is met with customisable reports, automated report generation and export, and in-software viewing and printing. Following USP and EP guidelines has never been easier with the new CVA (Calibrate/Verify Accessory). This new attachment ensures accurate performance of Mira P and the quality of results with a thorough calibration and verification routine. Mira P is IP67 rated and MILSPEC 810G tested,
as expected from our rugged handheld analysers. In combination with our new guided workflow, this makes Mira P a
perfect solution for the demanding pharmaceutical environment. From verification of morning deliveries to reviewing a day’s audit trail, Mira P helps increase the efficiency of the typical workflow in the pharmaceutical manufacturing industry.
METROHM SA (PTY) LTD Tel: (011) 656 1918 CPT: (021) 852 0213 DBN: (031) 265 0067 Fax: (011) 656 2698 076 643 7113 info@metrohm.co.za www.metrohm.co.za
Titration – a straightforward method with many application possibilities Because of their simplicity and accuracy, titration methods are used for a large proportion of the content determinations described in the monographs. Metrohm has developed hundreds of titration methods with Metrosensors based on the US Pharmacopeia (USP<541>) and European Pharmacopoeia. These methods include aqueous and non-aqueous acid-base titrations, as well as redox, surfactant and photometric titrations. Titrations using colour indicators are widely used in pharmacopeias. When performed manually, the results depend, quite literally, on the eye of the beholder. Photometric titration using the Optrode
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Analytical Reporter | Issue 6 | 2021
makes it possible to replace this subjective determination of the equivalence point with an objective process that is completely independent of the human eye. The great advantage of this is that the chemistry does not change - that is, the standard operation procedure generally does not have to be adapted. METROHM SA (PTY) LTD Tel: (011) 656 1918 CPT: (021) 852 0213 DBN: (031) 265 0067 Fax: (011) 656 2698 076 643 7113 info@metrohm.co.za www.metrohm.co.za
