Premium labels – a must for nutraceutical products
Embrace cultural diversity
Cultural diversity is a key characteristic of the vibrant African market. No two regions are the same with consumer preferences and trends varying from one African country to the next. This unique focus is beckoning more suppliers to set up shop in Africa to be closer to the markets they serve.
Our quarterly trade magazine, P&C Review Africa is a great tool to build awareness of solutions that are ideal for the African personal care and pharma manufacturing industries. In our Q2 edition, we explore mineral UV filters for everyday skincare to protect and care for African skin. You can read more about this on page 7. On page 11, we look at health and wellness solutions for the African market with a spotlight on science-driven resveratrol for ingestible and topical applications.
If you’re looking to power up your personal care formulations, turn to page 16 to read about PCA Glyceryl Oleate – a natural emollient that is ideal for hair and skincare applications. Our packaging feature in this edition delves into the role of premium labels in elevating brands in the competitive nutraceutical market and in building trust with consumers. Turn to page 18 to read more.
I hope you enjoy our magazine!
ADVERTISERS’ INDEX
CJP CHEMICALS 17 www.cjpchemicals.co.za
CRODA BEAUTY 8 https://www.crodabeauty.com/en-gb
HERSOL MANUFACTURING LABS 10 www.hersol.co.za
IMCD SA 14 www.imcdsa.co.za
ORISOVISTA 3 www.labelandpack.africa
SAVANNAH FINE CHEMICALS 12 www.savannah.co.za
This partnership with Sanofi will empower Biovac as an African manufacturer to champion polio eradication
Sanofi and Biovac partner to produce polio vaccines
SANOFI AND BIOVAC have entered an agreement designed to enable the regional manufacturing of polio vaccines to serve the potential needs of over 40 African countries. The partnership with Sanofi makes Biovac the first African producer of IPV on and for the African continent and supports the Africa Centers for Disease Control and Prevention’s ambition to have 60% of vaccines used throughout Africa produced on the continent by 2040.
Thomas Triomphe, executive vice president, vaccines, Sanofi: “For 40 years, Sanofi has supplied billions of polio vaccine doses globally, supporting the world getting close to polio eradication. But with the COVID-19 pandemic, many routine pediatric vaccination programs were halted or disrupted. Catching up will be key to preventing a rise in cases in many countries worldwide and this Sanofi partnership with Biovac is a step in that direction. Establishing this manufacturing partnership now, ahead of time, is key to enabling Biovac’s manufacturing capabilities for future international tenders.”
Dr Morena Makhoana, chief executive officer, Biovac: “We are very proud of this partnership with Sanofi, which will empower Biovac as an African manufacturer to champion polio eradication on and for the continent by bringing manufacturing of IPV doses closer to people’s needs.”
Sanofi has been a critical partner of the Global Polio Eradication Initiative (GPEI) since
1988 and has supplied the world and UNICEF with more than 1.5 billion doses of IPV through GAVI, the Vaccine Alliance, which aims to vaccinate the populations of more than 70 of the poorest countries on the planet with the aim to eradicate polio.
Sanofi will continue to produce the bulk of IPV and Biovac, which will hold the marketing authorisation, will be responsible for late-stage formulation, filling, packaging and delivery of millions of IPV doses to UNICEF for GAVI countries in Africa.
Based in Cape Town, South Africa, Biovac is a leading biotechnology company and an African centre of excellence for specialising in the development and manufacture of vaccines and other biologicals. These products are destined for patients in Africa and beyond. Polio is a highly contagious disease that mainly affects children under five years of age, who suffer the highest burden of temporary or permanent paralysis and death. Polio is an incurable infection that can only be prevented through immunisation. One in 200 infections leads to irreversible paralysis.
Over the last 30 years under the GPEI, 2.5 billion children have been immunised against polio resulting in a 99% reduction in the number of cases worldwide. At the end of 2023, polio was endemic in only two countries (Afghanistan and Pakistan). Due to the global effort to eradicate the disease, almost 20 million people have been saved from paralysis.
Upgraded application labs for Symrise Nigeria
Syrmise, A GLOBAL manufacturer of flavours, fragrance, cosmetic and nutritional ingredients, recently unveiled its newly upgraded application laboratories in Lagos, Nigeria.
According to Symrise Nigeria, the Nigerian market is central to the company’s growth. This guided its decision for capacity enhancements that create a launch pad for better value delivery to consumers in the region.
Symrise shared this during a press conference and facility opening event hosted for customers at its new facilities in Ikeja.
Speaking about the company’s activities in Nigeria, Lilian Regnier, president, Symrise Europe, Africa, Middle East said, “Symrise Nigeria has operated in the country for over 30 years. We have invested in building, maintaining and running our operations here. Nigeria represents a pathway to growth for us in the central, east and west African regions and we feel confident that the economic trajectory of the country will serve as a net positive to global manufacturers and organisations that believe in this country’s future.”
The size of the personal care segment in Nigeria is estimated at $1 billion, with SMEs gaining incremental
market share as they account for over 94% of businesses in the country. The new state-of-the-art application labs create for several opportunities for Nigeria’s SME businesses.
Sofiane Berrahmoune, Symrise vice president for Africa, Middle East, Turkey and Russia in the Taste, Nutrition & Health Division, affirmed that “this new facility enables us to serve our customers while understanding the market better and to serve it more effectively.”
Iyabode Ogunwole, key account manager, Symrise Nigeria, added: “We work with local partners for blending and flavours to reach SMEs and develop the market.”
The upgraded facility is strategically poised to cater to the diverse needs of the personal care and food and beverage industries, offering tailored solutions that empower different sized manufacturers to thrive in a competitive environment.
Looking ahead, Symrise Nigeria is poised for sustained growth and expansion in wider African market. With a clear vision, the subsidiary aims to continue pioneering innovation, driving value creation and fostering mutually beneficial partnerships that propel the industry forward.
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2
Sun smart: the science behind mineral UV filters
In the ever-evolving world of skincare, and with the growing awareness of the dangers of chemical sunscreens, mineral UV filters are emerging as a game changer, offering a safe and sustainable alternative for sun protection.
The latest consumer trends in sun protection emphasise sustainability, natural ingredients, multifunctionality and higher sun protection, with consumers seeking reef-friendly formulas free from oxybenzone and octinoxate.
These trends are driving the demand for lightweight, non-greasy textures that blend seamlessly into skincare routines. Moreover, suncare products incorporating antioxidants and hydrating ingredients are gaining popularity, providing not just protection from UV rays but also nourishment for the skin.
Mineral filters in daily skincare
Inorganic UV filters, also known as mineral filters, stand out for their reliability and safety, offering sun protection by creating a physical barrier on the skin's surface.
Incorporating mineral UV filters into an everyday skincare regime is a straightforward yet pivotal step towards safeguarding the skin. This is done by applying a generous amount of mineral sunscreen to all areas of skin exposed to the sun, be it the face, neck, or hands.
Make healthy skin a priority
Prioritising sun care not only preserves skin’s health and appearance but also safeguards against serious health concerns associated with excessive sun exposure, such as the non-melanoma cancers, basal cell carcinoma, squamous cell carcinoma, and the aggressive melanoma cancers originating from melanocytes.
According to the World Health Organization, around two to three million non-melanoma skin cancers and 132 000 melanoma skin cancers occur each year due to excessive sun exposure. What’s more, up to 90% of visible signs of ageing, like wrinkles and age spots, are attributed to UV exposure.
Prioritising sun care not only preserves skin’s health and appearance but also safeguards against serious health concerns
Formulation friendly mineral filters It can be challenging to develop sun care products that meet regional limitations on allowable UV filters, levels and combinations, while at the same time being sustainable and catering for product conscious consumers.
For those seeking a bit of colour and coverage, a tinted mineral sunscreen can be a splendid choice, providing a subtle, naturallooking glow whilst keeping skin protected. Consistency is the cornerstone of reaping the full benefits of mineral UV filters, ensuring the skin remains radiant and shielded against the elements daily.
Croda Beauty’s Solaveil™ Titanium Dioxide (TiO 2) and Zinc Oxide (Z n O) UV actives are the ideal mineral UV filters for sun care formulations. Also available as powders and dispersions, they are designed to enable formulators to meet diverse consumer needs and global regulatory requirements. They offer formulation versatility, enhanced stability, transparency, and high SPF benefits.
Zinc oxide, a key player in the sun care category, is not only celebrated for its sunreflective properties but also for its calming effect on the skin. Its anti-inflammatory prowess aids in alleviating irritation and discomfort, making it an ally for those battling conditions such as rosacea or eczema.
Titanium dioxide is renowned for its gentle touch, ensuring that even the most delicate of skins can enjoy the sunshine without fear of adverse reactions.
These filters don’t just prevent the external signs of ageing and damage induced by UV exposure, but also nurture skin's inherent health, preserving its natural balance and well-being.
Contact Croda Beauty for more information and formulation guidance.
Unlock new opportunities for your brand with Hersol
In the evolving landscape of complementary medicines, finding a contract manufacturer that aligns with your brand’s vision, values and quality standards is paramount. Amidst the plethora of options, Hersol brings a wealth of knowledge and unrivalled expertise to stand out as the ultimate partner in nutraceutical manufacturing.
Consisting of a team of seasoned professionals who are well-versed in the latest trends, regulations and advancements in the field, Hersol Manufacturing Laboratories (Hersol) understands that one size does not fit all. That is why the business offers customisable solutions tailored to meet your unique specifications and market demands.
Whether you are looking to develop a new product from scratch, optimise an existing formulation for better efficacy and consumer appeal or scale-up production, the contract manufacturer’s dedicated departments in research and development, regulatory affairs and quality assurance work closely with you to turn your vision into a reality.
Hersol views its clients as partners and prioritises collaboration in every step of the process to understand their goals, address any concerns and exceed their expectations.
“With responsive communication and a customer-centric approach, we ensure a seamless and hassle-free experience from start to finish. Transparency and integrity are the cornerstones of our business philosophy.
We believe in fostering open and honest communication with our clients through every step of the process, from pricing and timelines to raw material sourcing and regulatory compliance,” says Aadila Razak, regulatory affairs manager and NPD pharmacist at Hersol.
Supreme quality and efficiency
Equipped with state-of-the-art facilities, Hersol uses the latest technologies and manufacturing processes to ensure unparalleled quality and efficiency. From raw material sourcing to formulation development and packaging, every step of the manufacturing process is meticulously executed without compromising on quality.
“Licensed by the South African Health Products Regulatory Authority, we adhere to stringent quality control measures throughout our sourcing and manufacturing processes to uphold high standards of authenticity, quality and compliance. This occurs before any raw materials enter our manufacturing plant and any finished product leaves the facility,” she adds.
Hersol’s pilot scale production facilities are equipped with the same state-of-the-art equipment as its full-scale operations, ensuring consistency and accuracy throughout the development process.
Razak comments: “By offering our clients the option of trial batches, we can identify potential issues or optimisations early on, saving time and resources in the long run.”
An assortment of dosage forms
At Hersol Manufacturing Laboratories, versatility is key.
“We understand that different nutraceutical products require different dosage forms to cater to diverse consumer preferences and needs,” Razak explains, adding that this is why the business specialises in manufacturing a wide range of dosage forms.
With us you will experience the difference first-hand
Whether it’s traditional gelatine capsules or vegetarian capsules, Hersol has the expertise to produce capsules in various sizes, colours and formulations. From standard compressed tablets to chewable and dual layer tablets, the company can manufacture tablets in different sizes, shapes and colours to suit your requirements.
With its state-of-the-art blending and powder filling capabilities, the manufacturer can produce custom powder blends and single-serve sachets for convenient consumption and accurate dosing.
“From tinctures and syrups to emulsions and suspensions, we have the equipment and expertise to manufacture liquid formulations with accurate dosing and consistent quality. In addition to oral dosage forms, we also produce topical products such as creams, lotions and gels,” she adds.
No matter the dosage form, Hersol ensures strict adherence to quality standards and regulatory requirements to deliver safe, effective and market-ready complementary health products. With its diverse manufacturing capabilities, clients are empowered to explore new product formats and expand their product offerings to meet evolving market needs.
Experience the difference
With Hersol Manufacturing Laboratories as your contract manufacturer, you can rest assured that every aspect of your product’s development and production is in capable hands.
“Our unmatched expertise, cutting-edge facilities, unwavering commitment to quality and dedication to customer satisfaction are among the many reasons you should choose us as your contract manufacturer,” Razak says. “With us you will experience the difference firsthand while you unlock
endless possibilities for innovation and growth in complementary medicines.”
Discover the power of partnership with Hersol Manufacturing Labs!
At Hersol, we put people first. Our commitment to our clients goes beyond mere production – we’re dedicated to transforming your vision into reality. With our unparalleled expertise in formulation development, meticulous raw material sourcing, and cutting-edge pilot scale production capabilities, Hersol empowers you to bring your innovative concepts to life.
Why choose Hersol as your contract manufacturer? Because we understand the importance of trust and reliability in every step of the journey. From concept to creation, we ensure that every aspect of product development and production is handled with precision and care.
With our unmatched expertise, cutting-edge facilities, unwavering commitment to quality and dedication to customer satisfaction, choose us as your contract manufacturer, unlock endless possibilities for innovation and growth in the complementary medicines industry and experience the diff erence first-hand.
Hersol Manufacturing Labs – hersol.co.za
Hersol’s production manager, Tumelo Langa and quality assurance manager, Theresa Quinlan
Aadila Razak, Hersol’s regulatory affairs manager and NPD pharmacist, alongside factory co-ordinator, Kevin Duraan
Quality, efficacy and trust are paramount in the resveratrol-based ingredients market. Leading suppliers, Evolva and Lallemand are committed to ensuring sustainable practices and providing science-driven solutions for ingestible and topical applications.
Trans-resveratrol (also known as resveratrol) is a polyphenolic compound found in plants such as berries, peanuts, and grapes. Initially recognised as the key antioxidant ingredient in wine, it was associated with the cardiovascular benefits seen in the French paradox. The paradox originated from the fact that French people had relatively low rates of coronary heart disease (CHD) despite consuming a diet high in saturated fats.
Over time, resveratrol has undergone extensive investigation for various health benefits, including skincare, women’s health, and bone health. Impressively, there have been more than 18 000 scientific publications and over 280 human clinical trials dedicated to resveratrol.1
Scientific understanding has evolved beyond resveratrol’s role as a mere antioxidant that counteracts reactive oxygen species (ROS). Beyond its antioxidant properties, resveratrol has been reported to activate Sirtuin 1 (Sirt1), often referred to as the ‘longevity gene’ and linked to increased lifespan. Additionally, it activates 5’ adenosine monophosphate-activated protein kinase (AMPK), a protein associated with energy metabolism and mitochondrial function. Resveratrol acts as a potent vasodilator by stimulating nitric oxide (NO) production. These four key mechanisms, which may happen
simultaneously and are involved in many biological processes, explain the diverse reported benefits of resveratrol across various health areas.
As a supplier and producer of resveratrol for dietary supplement and personal care applications, Evolva and Lallemand remain committed to advancing scientific knowledge and supporting customers’ needs.
Not all sources are equal
Consumers hold a positive perception of resveratrol due to its potential benefits across various health areas, including cognitive health, cardiovascular function, skin health, eye health, bone health, and women’s health.
numerous published studies on resveratrol, there remains a need for more sciencebased evidence on this ingredient.
Available sources on the market
• Plant-sourced resveratrol – although the ingredient is perceived as natural, plantderived resveratrol exists in minor quantities. Extracting sufficient bulk material (for example 1kg) requires extensive land use, water consumption and other natural resources. Additionally, soil contaminants such as pesticides and heavy metals can be co-extracted with resveratrol, impacting the quality of the final product.
As consumer demand grows for natural and sustainable ingredients supported by clinical evidence, brand owners face the urgent task of meeting these expectations.
With sustainability discussions also gaining momentum, it is no longer sufficient merely to claim that an ingredient is scientifically backed. Consumers want robust clinical data to support claims. For this reason, manufacturers need to consider the number of clinical studies while prioritising study quality and design to provide meaningful evidence of health benefits. However, despite
• Synthetic resveratrol – chemically synthesised resveratrol uses heavy metals as catalysts, and harsh solvents can occur during the reaction. Although purity is high, the disposal of these solvents and metals is environmentally unfriendly. Consumer perception of synthetic ingredients is often negative, prompting brand owners to seek alternatives.
• Precision fermentation – Veri-te™ and Juneo™, Evolva’s ingestible and topical resveratrol alternatives, are produced through precision fermentation, primarily using microorganisms to metabolise
renowned for its proprietary fermentation technology, was recently acquired by Lallemand, a Canadian leader in yeast and bacteria solutions.
Evolva specialises in natural ingredients derived from yeast, serving various markets such as flavours, fragrances, health ingredients and personal care. Both companies are committed to prioritising human clinical studies, providing scientific validation for our ingredients. With a global presence and extensive expertise, Evolva and Lallemand inspire trust among consumers seeking cuttingedge solutions. These solutions are available throughout Southern Africa from Savannah Fine Chemicals.
natural raw materials. The patented and proprietary fermentation process ensures high quality ingredients, meeting the demands of manufacturers and brand owners in the dietary supplement and personal care industries.
Unlock beauty from within
When it comes to resveratrol and skincare, a quick online search will reveal many articles touting its antioxidant properties and the positive impact on skin health. However, a closer examination of these studies reveals that most of them explore the benefits of resveratrol in combination with other active ingredients. As a result, it remains challenging to definitively attribute positive effects solely to resveratrol.
Beyond its antioxidant properties, resveratrol influences skin health through additional mechanisms. Notably, the activation of SIRT1 and its acting as a vasodilator play crucial roles in enhancing skin appearance and reducing wrinkles. To investigate this further, Evolva and Lallemand conducted a clinical trial on the forearm, focusing on the effects of resveratrol as the sole active ingredient. Participants received Veri-te™ capsules (for beauty from within) and/or Juneo™ facial cream (for topical application).
baseline, and placebo results. Evolva and Lallemand eagerly await the publication of these findings in a peer-reviewed journal.
How to innovate with resveratrol
In recent years, the Veri-te™ and Juneo™ brands have captured the interest of global customers seeking excellence for their finished products.
Veri-te™, a trusted resveratrol brand, stands as a globally recognised symbol of quality and trust in the resveratrol market. It has been prominently featured in dietary supplements worldwide. Supported by rigorous clinical studies, Veri-te™ offers evidence-based benefits for cognition, bone health, and overall quality of life. Notably, it played a pivotal role in the groundbreaking RESHAW study (resveratrol for healthy ageing in women), which won a NutraIngredients award in 2020. Elevating personal care, Juneo™ meets the high standards of the personal care industry for high purity. Like Veri-te™, Juneo™ is backed by robust clinical research, ensuring its efficacy and safety.
The clinical trial followed a randomised, placebocontrolled, double-blind design, and the results were compelling. Resveratrol significantly improved skin appearance in both applications. Moreover, the combined use of Veri-te™ and Juneo™ showed even more remarkable outcomes, surpassing
Veri-te™ and Juneo™ are a powerful duo representing innovation, quality, and scientific rigor. Whether you’re formulating dietary supplements or personal care products, these resveratrol brands deliver excellence to meet the consumer demands of today.
REFERENCE: 1. PubMed, June 2024
Lallemand Bio-Ingredients | Health Ingredients –https://bio-lallemand.com/health-ingredients/ Savannah Fine Chemicals – www.savannah.co.za
With a focus on lipofuscin, Chemyunion has pioneered Iselight, a solution that targets ‘cellular waste’ by enhancing the homeostasis of the cellular detoxification system.
Age spots emerge as pigmented lesions ranging in colour from light brown to black and varying in size. Typically found on sun-exposed skin, these spots not only result from the accumulation of melanin but also involve the presence of ‘cellular waste’ or lipofuscin.1,2
Mechanism of action
Lipofuscin, a yellow-brown pigment, accumulates in ageing cells due to residues of cellular material that are not fully digested or eliminated through the regular cellular renewal process. In simpler terms, lipofuscin is commonly known as the ‘ageing pigment’ and is linked to the gradual buildup of cellular waste. 3 To address the buildup of cellular waste, it is essential to comprehend the mechanisms involved in cellular recycling, like autophagy. This cellular self-cleaning process is induced during nutrient deprivation, orchestrated by the dissociation of the mTORC1 protein complex.
This crucial step triggers partial dephosphorylation, initiating the autophagic mechanism. Notably, mTOR, a key component in autophagy regulation, ensures homeostasis, responding to
In the pursuit of combating age spots, Chemyunion introduces Iselight® , a groundbreaking active ingredient
the cell's physiological conditions and environmental stress. Reducing mTOR levels is essential for autophagy induction, playing a pivotal role in phagophore and autophagosome biogenesis. 4
The widely used marker LC3 identifies autophagosome formation, while various autophagy-related proteins (ATGs) contribute to membrane formation.
Figure 1: Analysis by Immunofluorescence of lipofuscin (green) and counterstaining with DAPI (blue, marker of cell nuclei), microscopic images with 40x magnification
The Parkin protein stands out for monitoring and selecting damaged mitochondria, facilitating their autophagic degradation. 4
While autophagy is crucial, its sole action is not sufficient to prevent lipofuscin formation. The proteasome system complements autophagy, but lipofuscin accumulation inhibits proteasome activity. Mitigating ‘cellular waste’ requires the synergy of autophagy and proteasome systems, with autophagy proving more efficient in removing oxidised proteins in aged cells. 5
In the pursuit of combating age spots, Chemyunion introduces Iselight®, a groundbreaking active ingredient born from meticulous research and ingredient screening. This solution targets the core factors contributing to age spot formation by enhancing the homeostasis of the cellular detoxification system.
Iselight operates through the activation of autophagy and proteasome activity, effectively reducing different types of skin blemishes. The synergy between the resurrection plant and green coffee extracts forms the basis of Iselight, blending the antioxidant power of green coffee with the regenerative vitality of the resurrection plant.
Did you know?
IMCD was recently appointed the distributor of Chemyunion’s ingredients and formulation technologies in South Africa, Ghana, Nigeria, Botswana, Zambia, Kenya, Uganda, Ethiopia, Swaziland, Namibia, Madagascar, Zimbabwe, Malawi and Tanzania.
Detox efficacy
This test aimed to assess the detoxifying effect of the resurrection plant and green coffee active in lipofuscin reduction, using an in vitro model.
The evaluation was carried out on human dermal fibroblasts treated with the active ingredient at 0.016% and incubated for 24 hours for subsequent irradiation with three doses of UVA per day, totaling 7J/cm 2 (see figure 1). After this period, the cells were analysed using an in vitro immunofluorescence technique known as the SenTraGor method.
The irradiated and active-treated group was compared to the control group (with no treatment) and the irradiated control group (with no treatment and irradiated with UVA 7J/cm2).
The active at 0.016% was able to eliminate lipofuscin generated by exposure to UVA radiation, matching the control group without irradiation stress.
Skin brightening and pro-ageing effect
The brightening effect on age spots and general pigmentation, and improvements in skin texture and elasticity (anisotropy) were evaluated in this test. Volunteers applied a product containing Iselight for 56 days, with intermediate measurements taken during the treatment period.
The trial took place in a clinical, randomised, single-blind, placebo-controlled setting. It involved two groups of female volunteers (68 in total), who received either a placebo cream (34 volunteers) or a cream formulation containing resurrection plant and green coffee active at 2%
Shaping tomorrow’s
Beauty
At IMCD Beauty & Personal Care we embrace ingenuity and passion as we embark in a constant quest to help you empower people’s Beauty.
With each innovative solution we develop worldwide we seek out trends and identify whats next in a sustainable, efficient and profitable way.
(34 volunteers). Participants applied the formulations topically to their facial skin, hands, and forearms twice a day (morning and evening). In addition, all volunteers applied a sunscreen formulation every morning. All assessments were conducted by a dermatologist.
Volunteers underwent a 56-day topical treatment with either placebo formulation or Iselight 2% formulation on facial, hands, and forearm areas. Volunteer obligations included refraining from applying other
similar treatments, avoiding aesthetic treatments such as exfoliating, Botox, and peels, adhering to use conditions of tested treatments, maintaining hygiene and makeup habits, and abstaining from makeup in the experimental area during control days at the research centre.
In this clinical trial, the clinical effects of the topical application of the placebo and 2% active formulations were assessed after 28 and 56 days. Clinical, skin macroscopic, and biomechanical parameters were quantified. Evaluations were conducted by a technician and a dermatologist before any treatment (day 0), and at 28 days and 56 days post treatments. All measurements at day 0, 28, and 56 involved a 30-minute rest in a humidity- and temperature-controlled room.
Analysis of spots on back of hands
This analysis involved taking photographs with a digital Canon camera EOS 60 D and using a Chroma Meter CR 400 (Konica Minolta Sensing Americas) to measure the lightening of spots and skin homogeneity. Notable improvements
in various skin features on both the hands and face were observed after 28 and 56 days of consistent use.
The results shown in figure 2 reveal notable improvements in various skin features on the hands and face after 28 and 56 days of consistent use.
The active ingredient at 2% demonstrated a substantial reduction of 25.9% and 30.8% in hand spot length after 28 and 56 days, respectively, while the placebo formulation yielded no discernible effects.
A time-dependent enhancement of 44.7% and 63.2% in hand skin homogeneity was observed at day 28 and day 56 (see figure 2), respectively, with the active ingredient, whereas the placebo exhibited an increase in skin homogeneity solely after 28 days, with no discernible effects at day 56. These findings highlight the efficacy of the resurrection plant and green coffee active ingredient in promoting skin brightness and pro-ageing effects.
Analysis of spots on face
Facial analysis involved acquiring three images (front, left and right sides) of volunteers using Visia CT equipment (Canfield Scientific). These images were standardised using a digital Canon camera
for subsequent analysis of spot lightening through the FrameScan software (Teradyne). Skin evenness and spot lightening on the facial and hand areas were determined using the total surface of spots and the Haralick homogeneity index.
Clinical dermatological evaluations were conducted by a dermatologist on day 0, day 28, and day 56.
The active 2% formulation significantly increased facial skin homogeneity, improving by 44% and 21.5% at day 28 and day 56, respectively. In contrast, the placebo showed a 14.3% improvement in skin homogeneity after 28 days of treatment, with no effects observed at day 56. Facial images of volunteers also illustrated the overall improvement of skin features when compared to the placebo group.
REFERENCES:
1. Choi W, Yin L, Smuda C, Batzer J, Hearing VJ, Kolbe L. Molecular and histological characterization of age spots. Experimental Dermatology. 2017;26(3):242-248. doi: https:// doi.org/10.1111/exd.13203
2. PORTA EA. Pigments in Aging: An Overview. Annals of the New York Academy of Sciences. 2002;959(1):57-65. doi: https://doi.org/10.1111/j.1749-6632.2002.tb02083.x
3. Bourne GH. Lipofuscin. Progress in Brain Research. Published online January 1, 1973:187201. doi: https://doi.org/10.1016/s0079-6123(08)60687-1
4. Kim H, Park SY, Moon S, Lee J, Kim S. Autophagy in Human Skin Fibroblasts: Impact of Age. International Journal of Molecular Sciences. 2018;19(8):2254. doi: https://doi.org/10.3390/ ijms19082254
5. Keller JN, Dimayuga E, Chen Q, Thorpe J, Gee J, Ding Q. Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain. The International Journal of Biochemistry & Cell Biology. 2004;36(12):2376-2391. doi: https://doi.org/10.1016/j.biocel.2004.05.003 Chemyunion
Figure 2: Lightening and increased skin tone homogeneity of the hands treated with 2% active ingredient, Iselight at 28 and 56 days
Harness the power of natural emollients
African skin and hair possess unique characteristics that require tailored care. Natural or natural-based hair and skincare products are growing in popularity in Africa. To meet market demands, CJP Chemicals offers a true multifunctional ingredient, PCA Glyceryl Oleate.
African hair, often naturally curly or coily, is prone to tangling, dryness, and delicacy, necessitating specialised haircare products that emphasise hydration and manageability.
African skin often requires products that enhance hydration and skin barrier function, as dark skin tones can be prone to dryness and irritation.
CJP Chemicals offers a wide range of natural, sustainable and biodegradable emollients and moisturising ingredients addressing these consumer needs.
Universal natural cationic conditioner
PCA Glyceryl Oleate is a moisturising ingredient that can be used in hair and skincare applications. This natural multiplant-based ester is a pure multifunctional in viscous liquid form. It works in two ways – as a deposition
PCA Glyceryl Oleate is a moisturising ingredient that can be used in hair and skincare applications
DISCOVER
Flexible processing benefits
• PCA Glyceryl Oleate is suitable for hot and cold mixing processes.
• It can be added to the oil phase, or post-emulsification.
• It is suitable for use in o/w, w/o, surfactant, anhydrous and alcoholbased formulas.
aid in hair care applications to improve wet combing and offers moisturisation and protection for skin and scalp. These numerous benefits are coupled with a pampering caring feel.
In hair cleansing formulas, the squeaky feel after the removal of dirt, sebum and pollutants often reveals damaged open cuticles. PCA Glyceryl Oleate eases rinsing and allows for the deposition of light oils or silicones onto and along the entire hair strand, promoting easy combing and styling with a weightless feel.
Natural hair and skin conditioner
• PCA Glyceryl Oleate boosts naturality and performance in skin, hair and colour care applications.
• Use it to formulate a skin, scalp and hair conditioner with cationic charge (@pH<5.5) and high substantivity.
• It has a positive influence on skin moisturisation.
• PCA Glyceryl Oleate acts as a film former and deposition aid for lipophilic caring ingredients.
• It is a natural alternative for synthetic quaternary ammonium compounds.
• It helps to improve wet and dry hair combability.
In skincare formulations, it moisturises and forms a perceivable light film on skin. This is due to the presence of pyrrolidone carboxylic acid (PCA), which is also part of skin’s Natural moisturising factor (NMF). This completes its characteristic caring and pampering sensory profile. With PCA Glyceryl Oleate, skin is left feeling moisturised, soft and supple. This ingredient is 100% natural-based according to ISO 16128. It is also vegan and fits in perfectly with the clean beauty movement. PCA Glyceryl Oleate is readily biodegradable and non-toxic to algae. Based on 100% renewable resources, it is another small step towards a healthier planet and the respectful use of resources, as well as a big step towards helping consumers feel good in their own skin.
PCA Glyceryl Oleate is suitable for rinseoff and leave-on products in the hair care, scalp care, skin moisturising and colour care categories. Claims aligned to the ingredient’s benefits include ‘effortlessly easy-to-comb hair’ and ‘pampered, wellcared for and moisturised skin’.
As we age, our skin undergoes natural changes. Collagen production decreases and skin loses moisture, leading to wrinkles and sagging. A growing number of women in the 50+ age range are highly concerned about the effects of ageing on their skin.
Discover our cutting-edge antiaging solutions! Our products harness the power of nature to rejuvenate and revitalize your skin. From emollients to actives, we’ve got you covered. Say goodbye to sagging skin and hello to radiant, youthful skin.
• Biomimetic ingredients
• Anti-sagging
• Restoration
• Elasticity
• Protection
• Moisturization
PCA Glyceryl Oleate is one molecule and profits from synergistic effects
In a rapidly evolving market like nutraceuticals, product labelling stands as a crucial touchpoint between brands and consumers. Premium labels aren't just about aesthetics, they're also about compliance, trust and effectively communicating vital information about your products – this is where Pyrotec PackMedia's expertise shines.
Labels you can trust
Nutraceutical products must comply with stringent labelling requirements, as per the
Premium labels – a must for nutraceutical products
Pyrotec PackMedia explores the role of premium labels in elevating brands in the competitive nutraceutical market and in building trust with consumers.
Foodstuffs, Cosmetics and Disinfectants Act (Act 54 of 1972). So, trust is of paramount importance. Businesses need to feel confident that their labels meet every guideline and regulation. Pyrotec PackMedia, with its long-standing history and unflinching commitment to quality, provides this trust.
Brand owners and manufacturers can rest assured that they are in safe hands. With Pyrotec PackMedia’s lead times and
decades of experience, the supplier makes the complex process of product labelling for nutraceutical products a seamless, worryfree experience.
Essential information
It is crucial to recognise the importance of displaying comprehensive, legally compliant information on product labels. The following list includes the information required to appear on dietary supplement labels, as per
When it comes to labelling, every detail matters
Pyrotec PackMedia supplies informational multipage labels for nutraceutical products
Klipstrip premium labels from Pyrotec PackMedia
the Foodstuffs, Cosmetics and Disinfectants Act:
• Brand name and product name.
• Manufacturer/packer/distributor name and street address.
• Country of origin, date of manufacture, expiry date and batch number.
• Product size or weight.
• A clear list of the ingredients.
• The names of any preservatives or colorants included in the product.
• Nutritional table if a nutritional claim is made.
• All labels must be in English.
• If a product has healing or medical claims, it needs SAHPRA registration.
• Products with slimming or muscle enhancement claims also require SAHPRA registration.
• Misleading claims are not permitted on labels.
• Banned ingredients, such as hydroquinone (used for skin lightening), are not permitted.
A partnership built on quality When it comes to labelling, every detail matters. This is why you should choose Pyrotec PackMedia’s premium labels as an investment in compliance, quality and consistency. The label supplier understands the ins and outs of labelling requirements for the nutraceutical market and is perfectly positioned to offer an exemplary service.
An experienced and reputable partner such as Pyrotec PackMedia can take the stress out of your labelling process. This not only allows you to focus more on your core business but also guarantees peace of mind knowing that your labels meet all regulatory requirements.
In a market where consumer trust is paramount, Pyrotec PackMedia steps up to the challenge, setting the gold standard for nutraceutical product labelling.
