The crucial role of mineral salt adjuvants in vaccine manufacturing

Because they stabilise the antigen during processing, storage and application, mineral salts are an indispensable part of vaccines. Mineral salts fulfil several technological functions such as acting as buffers, pH adjusters, adjuvants, chelating agents and stabilisers.

Since most vaccines are parenterals, the highest standards of purity and quality are required. Dr. Paul Lohmann, represented locally by Nautilus Chemicals, offers a wide range of highly pure mineral salts with the following parameters:

• bioburden (TAMC/TYMC) and additional parameters

• low in endotoxin grade

• heavy metal profile according to ICH Q3D

• constant production processes

• residual-solvent free

• animal-component free

• BSE/TSE-free

• GMO-free.

As a commitment to all customers’ requirements, the mineral salts are also:

• multi-compendial (e.g. Ph.Eur., BP, USP/NF, JP)

• low in RNase grade

• available as custom premixes and salt solutions

• available in customised packaging.

Outstanding expertise

Dr. Paul Lohmann is based in Germany and guarantees a high level of transparency and security along the entire supply chain. Over 135 years of salt development and production have strengthened the company’s know-how and have made it one of the world’s leading suppliers of high-quality salts.

Diverse production options enable the manufacturer to modify specific chemical and physical properties in order to produce tailor-made salts or salt solutions. High transparency and product quality make Dr. Paul Lohmann an ideal and reliable partner for salts used in vaccines.

Quality and consistency

Dr. Paul Lohmann’s GMP-certified purpose-built plant is used exclusively for the production of low endotoxin qualities using low endotoxin process water. Its consistently high quality minimises batch-to-batch variation in the production process and supports customers’ batch-to-batch consistency of the final vaccine formulation.

With its expertise in the chemical and physical modification of mineral salts and its customer-oriented corporate philosophy, Dr. Paul Lohmann is an ideal partner to turn customers’ ideas into reality. •