The Eye Examination During a Dental Procedure
Eniolami O. Dosunmu
4.1 The Examination
4.1.1 Vision
A vision examination is dependent on the age of the child and must be developmentally appropriate. Obtaining a vision prior to procedural sedation/anesthesia is not indicated, unless there is a concern that a baseline vision prior to procedural intervention is of importance and will have bearing on the postoperative outcome. In such settings, a formal vision should be obtained by an ophthalmologist. In circumstances where this is not possible, an assessment of vision should be obtained prior to the procedure by the dentist. An age-appropriate eye chart should be used. For children over the age 6 years, Sloan letters/Snellen eye chart is recommended. For children ages 3–5, use of LEA symbols® or HOTV letters is recommended. In preverbal or nonverbal children, preferential looking cards can be used for a vision assessment. Observation for whether there is a preference for one eye over the other is also another avenue, to assess vision. It may not always be accurate but is a quick evaluation tool. Knowing whether there was previous amblyopia, or vision loss, or if there is a need for refractive correction will be helpful during this assessment.
4.1.2 Pupils
The pupil examination is very important, as this will provide information about the integrity of the eye and also provides neurologic information. It is important to assess for whether the pupils are equal in size, reactive to light—both the direct and consensual response—and round in shape.
E. O. Dosunmu (*)
Cincinnati Children’s Hospital, Cincinnati, OH, USA
e-mail: Eniolami.dosunmu@cchmc.org
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2023 S. Thikkurissy, S. Golkari (eds.), History and Physical for the Pediatric Dental Patient, https://doi.org/10.1007/978-3-031-51458-6_4
Performing a pupil examination: Using a light source, the size of each pupil is determined, ensuring that both are equal in size. Next, the light is shone into one eye, and the reaction of the pupil is observed (a normal reaction is for pupil constriction), the light is then shone in the contralateral eye, looking for the same response (constriction of the pupil in that eye). Next, the light is shone into each eye—going back and forth—as the examiner swings the light source between both eyes; a normal fnding is constriction of the pupils. In the presence of a relative afferent pupil defect, when the light is shone from the unaffected eye to the affected eye, the pupils of both eyes will be noted to dilate.
A well-documented history will be helpful to determine if there is a previous anisocoria (unequal pupil sizes) or altered anatomy to the iris that would result in changes in the pupil shape, or previous optic nerve or neurologic injury that would result in a relative afferent pupillary defect.
4.1.3 Lids, Lashes, and Orbit
An external evaluation of the eyelids, the eyelashes, and the periorbital and orbital areas for any preexisting anatomical changes is important prior to any procedural sedation/anesthesia and prior to any dental procedure. External examination may also reveal infectious processes that would negate proceeding with procedural sedation and a dental procedure, for example, herpes simplex infection with active vesicles on the face, or in the periorbital area. It could also reveal changes suggestive of an active neurologic process, for example, a new-onset ptosis (droopy eyelid), or a facial droop that may necessitate deferment.
4.1.4
Motility
Motility of the extraocular muscles should demonstrate normal excursions of the extraocular muscles in the absence of previous ophthalmic disease such as trauma, known restrictive strabismus such as thyroid eye disease, known paralytic strabismus, or other orbital process. Assessment of extraocular motility may be important, post-procedure, in localizing, if there is a concern for an inadvertent ophthalmic complication/neurologic complication.
4.2 Sclera and Conjunctiva
The sclera and conjunctiva are typically white in color. Changes in the color may be suggestive of systemic illness, e.g., in jaundice there is a yellow discoloration to the sclera, and local trauma, e.g., a subconjunctival hemorrhage, or infection. The presence of an active conjunctivitis may warrant delay of the dental procedure.
4.2.1 Cornea
Examination of the cornea should demonstrate a clear “window” into the anterior chamber of the eye with no opacity/cloudiness/haze of the cornea. This is also a good time to evaluate for the use of contact lenses, which may need to be removed prior to procedural sedation/anesthesia. It is important to ensure proper closure of the eyes for the entirety of the procedure to ensure no corneal abrasions. It is recommended that an ophthalmic lubricating ointment/tears be placed, followed by manual eyelid closure to ensure no lagophthalmos (incomplete eyelid closure), and this is secured with the use of medical-grade tape.
4.2.2 Anterior Chamber
The anterior chamber is the space between the cornea and the iris plane. The use of a penlight/light source will be useful in determining the depth of the anterior chamber. When light is shone from the temporal aspect of the eye toward the nasal aspect, if the light can be seen nasally, the anterior is determined to the deep [1].
4.2.3 Red Reflex
Using a direct ophthalmoscope, one can identify the red refex in the eyes. In the absence of strabismus, media opacity, and retinal or optic nerve disease, the red refex should be symmetric in both eyes. The presence of a white or absent refex in a child, with no known previous history, should warrant immediate ophthalmologic evaluation.
4.2.4 Eye Reflexes
There are several eye refexes of importance that once should be knowledgeable of during procedural sedation/anesthesia for dental procedures/surgeries. These are discussed below.
Pupillary light refex: This was discussed above. This refex may be disrupted in the setting of anesthesia [2].
Oculocardiac refex: This refex results in a decrease in the resting heart rate when there is stimulation of the eye, orbit, or the extraocular muscles—usually through stretching of the extraocular muscles [2, 3]. This is more prominent in the pediatric population, where a dramatic drop in the heart rate can be seen.
Corneal refex: Tactile stimulation of the cornea results in blinking of both eyes [3].
Lacrimatory refex/refex lacrimation: This is tearing/lacrimation in response to various stimuli—stimuli to the cornea, conjunctiva, and nasal mucosa, bright lights, emotional upset, vomiting, coughing, and emesis [2, 3]. 4 The Eye Examination
Gusto-lacrimal refex/crocodile tear syndrome: Unilateral lacrimation that occurs during eating or drinking [3, 4]. This is typically seen after facial trauma or Bell’s palsy.
Bell’s phenomenon: Upward deviation of the eyes during eyelid closure against resistance [2]. This refex is present in 90% of the population [2, 3]. This can be absent in some local eye disease processes, such as an entrapped muscle from orbital trauma.
Oculo-respiratory refex: This results in a decrease in the respiratory rate, shallow breathing, or respiratory arrest when pressure is placed on the eye or orbit or when the extraocular muscles are stretched. When under general anesthesia with mechanical ventilation, this is often not appreciated; however, manipulation of the eye/orbital structures under sedation should warrant close evaluation of the respiratory status [3, 5].
Oculo-emetic refex: This results in increased nausea and emesis following extensive manipulation of the extraocular muscles [3]. This should be considered when dental and ophthalmic cases are combined, especially if the dental wounds are to be kept relatively dry.
4.3 Ophthalmic and Systemic Considerations Prior to Dental Procedures
There are several ophthalmic reasons to defer a dental procedure. One of those is an active infection periorbital and/or orbital process. An active herpes/varicella eruption that involves the orbital region or the facial region that has not been adequately treated is at risk for progression/systemic spread. An active preseptal infammatory/ infectious process and/or orbital cellulitis whose etiology is not dental is also at risk for progression/systemic spread. In an immune compromised patient, this could lead to dissemination in the setting of a dental procedure given the proximity to the orbits/facial structures and oral structures to one another. An active infectious, untreated, conjunctivitis is also another clinical indication to defer a dental procedure. An active keratitis is also a reason to defer a dental procedure, as these patients often need frequent topical application of topical antimicrobial medication that would contraindicate eye closure for the anesthesia. In addition, it is important to identify the source of the active infection, to ensure that it would also not result to a postoperative complication of the dental procedure/surgery. In the setting of an endophthalmitis, a dental procedure needs to be deferred, especially if the etiology of the endophthalmitis has not been elucidated. If it is an endogenous source (nondental source), this may also pose a risk for the dental procedure. In addition, in the setting of a compromised eye, without proper premedication with antimicrobials, as dental procedures are known to result in a transient septicemia, this could further compromise an already diseased eye.
Systemic diseases with ophthalmic manifestations should be accounted for when a dental procedure/surgery is to be performed, given the possible ophthalmic complications, and given the fact that known ophthalmic responses could mirror dental
healing as both have mucous membranes. Diseases such as epidermolysis bullosa could result in corneal abrasions or corneal scarring if proper preventative measures are not taken during the procedural sedation/anesthesia. Other diseases such as systemic and ocular graft versus host disease, Sjogren’s disease where the risk of ocular surface dryness is increased, and thyroid eye disease with proptosis with increased risk of dryness and decreased Bell’s phenomenon could also result in ophthalmic complications. Previous refractive surgery results in increased keratoconjunctivitis sicca [6], and knowledge of this could help during the sedation/anesthesia when the ocular surface is being protected. This is also important if there is a chemical or body fuid exposure to the ocular surface, or if there is trauma to the ocular surface during instrumentation of the teeth, or from accidental ocular surface exposure, as treatment may need to be altered to account for the prior refractive surgery.
4.4 Dental Local Anesthesia and Potential Ophthalmic Complications
There are many studies that discuss ophthalmic complications of unintended spread of local anesthesia during dental procedures [7–13]. The exact mechanism of the spread has been debated in the medical literature—intra-arterial, intravenous, localized spread, incorrect anatomic location of injection, etc. A careful ophthalmic examination prior to the start of the sedation/anesthesia will be very helpful to determine what the acute changes are and how to best treat them. With the use of general anesthesia in the pediatric population, the use of local anesthesia/blocks may be decreased, and these rare complications may not arise. We will briefy discuss the potential fndings/complications here: transient amaurosis (blindness), diplopia (double vision) with temporary paresis of one or more of the extraocular muscles, ptosis (drooping of the upper eyelid), mydriasis (dilation of the pupil), miosis (constriction of the pupil), nystagmus (involuntary movements of the eyes), and retrobulbar pain have been reported [7–11]. With the spread of the local anesthesia to the orbital space/into the ophthalmic circulation, the resulting fndings are secondary to the anesthetic effect and/or to the vasoconstrictor effect, as most anesthetics are used in combination with a vasoconstrictor. These are rare complications, and even more rare are the reports of permanent vision loss in the setting of local anesthetic use, where irreversible damage occurs to the ophthalmic circulation that supplies the optic nerve and/or retina [12, 13].
4.5 General Anesthetic Agents and Intraocular Pressure Changes
Studies have demonstrated that the newer inhalation agents (sevofurane, desfurane, and isofurane) used for induction anesthesia decrease the measured intraocular pressure (IOP) [14–17]. Ketamine has been reported to either have no effect on the IOP or to increase the IOP [14, 16, 17]. Succinylcholine has been consistently
shown to increase the IOP1 [4], and propofol has been shown to decrease the IOP [14]. The use of succinylcholine is generally avoided in an eye with an open globe/ penetrating/perforating injury as the increase in IOP may result in expulsion of the intraocular contents.
Nitrous oxide is frequently used in combination with one of the abovementioned anesthetic agents for anesthesia in dental procedures/surgeries. One study, in healthy adults, found the use of nitrous oxide only, has no signifcant effect on IOP [18]. The use of nitrous oxide is contraindicated if there is an ophthalmic surgical history where recent intraocular gas was used. In such settings, the nitrous oxide can rapidly expand in the intraocular gas, thus raising the intraocular pressure and resulting in the occlusion of the central retinal artery. Unfortunately, this results in permanent vision loss [19, 20]. It is important to have a complete ophthalmic surgical history, as this knowledge will prevent such an outcome. Patients with intraocular gas bubbles are ftted with a bracelet that is to remain on until removed by the vitreoretinal surgeon, once the bubble is completely resorbed [19].
Another thing of note with recent vitreoretinal surgery is positioning of the patient. Patients are typically placed in certain positions, so that the intraocular gas can help tamponade a retinal tear/detachment during the healing phase. These positioning needs should be taken into consideration prior to any sedation/anesthesia as the positioning needed for the dental procedure/surgery may be contraindicated to that needed during the vitreoretinal surgery postoperative period. Most young pediatric patients cannot adhere to the positioning rules for the duration of the time that is needed following vitreoretinal surgery; thus, silicone oil is used as a tamponade instead [21]. It should be noted that when there is silicone oil in the eye, prolonged supine position will lead to silicone oil bubbles in the anterior chamber; however, with upright position or with a prone position, this easily resolves.
It is also important to ensure avoid hypotension during anesthesia, as prolonged hypotension could lead to decreased perfusion of the optic nerve and retina and result in irreversible vision loss [22, 23].
4.6 Potential Ophthalmic Complications
from Dental Procedures
Corneal abrasions: These can result from chemical exposure, mechanical exposure (either from instrumentation or from debris), body fuid exposure, from ultraviolet light exposure (when lasers are used), or other traumas directly to the eye. Abrasions can also occur if the eyes were not carefully closed for the duration of the anesthesia, and the epithelial tissue degrades resulting in an abrasion. If the abrasion is inoculated with a microbe, a keratitis may result. An abrasion should be treated to ensure complete resolution with no long-term sequelae on vision. A keratitis in the setting of previous refractive surgery, especially laser-assisted in situ keratomileusis (LASIK), where a fap was created, can be diffcult to treat, if the microbe inoculates tissue beneath the fap.
Corneal and conjunctival foreign bodies: These can result from debris from the dental procedures. The eyes should be fushed with eye wash or saline and the patient referred to ophthalmology for further evaluation.
Subconjunctival hemorrhage: A subconjunctival hemorrhage results when there is a broken blood vessel beneath the conjunctival layer of the eye. These result from direct trauma or from increased Valsalva maneuvers that result in rupture of the vessels [24].
Retinopathy: Constant exposure to ultraviolet lights (during the use of lasers) without the use of proper protective glasses may result in a retinopathy.
Periorbital and subcutaneous emphysema: This is a rare complication and occurs often during tooth extraction when high-powered drills are used, whereby compressed air is forced into the subcutaneous tissues [25–27]. A careful examination of the eye or orbit and surrounding facial structures should be used as a guide for treatment.
Endophthalmitis: This is a serious, but thankfully rare complication. This could result from direct inoculation [28] or endogenous spread [29] in a patient. Immediate ophthalmology care should be sought in the setting of an endophthalmitis.
Trauma: Any noted trauma warrants immediate ophthalmology evaluation. One of the more serious complications is an open globe injury that needs immediate surgical intervention.
References
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Gift of Constantine, T. Godfray, 157, 203
Gloucester Cathedral Library, 82
Godfray, Thomas, 156, 157, 203
Golden Legend. See Voragine, J. de
Golden Litany, J. Skot, 151
Göttingen University Library, 9
Gouda printing, 30
Gough, John, 139, 184, 203, 204
Gough, Richard, 92, 199
Gourmont, Egidius, 196
Governayle of Health, Caxton, 90
Gower, J., Confessio amantis, Caxton, 15
Gradual, Sarum, 1527, 199, 205
Gradus comparationum, J. Toy, 1531, 150, 153
Graf, Urs, woodcuts by, 211
Grafton, Richard, 155, 181, 208, 209
Gray, William, 154, 155
Greek type, 235
Grenville Library, 61
Gringore, P., Castle of Labour, Verard, 206
Growte, John, 204
Groyat, John, 204
Gryphus, P., Oratio, Pynson, 163
Gueldres, Duke of, 67
Guilford, Sir Richard, 163
Guilibert, John, 112
Gulielmus de Saliceto, Salus corporis salus anime, R. Faques, 171
Guy of Warwick (Pynson), 70
Gybken, John, 227
H., A., bookbinder, 121, 233
H., I., printer, 37, 38
Hackett, John, 224
Haghe, Ingelbert, 82
Hain, L., Repertorium Bibliographicum, 39
Halberstadt Library, 14
Hampole, Richard de, Devout Meditacions, 134; Speculum Spiritualium, 194
Hardouyn, Gilles, 205
Haukins, John, 158, 166, 167, 168
Havy, Noël, 139, 140, 235
Hawes, S., Pastime of Pleasure, W. de Worde, 1509, 135
Hazlitt, W. C., 136
Heber sale, 35, 40
Heerstraten, E. vander, 77
Helias, Knight of the Swan, W. de Worde, 1512, 136
Henry VII., 55, 68, 212
Henry VIII., 68, 164, 165, 212
Herbal, The Grete Herball, 1529, 156
Herbert, William, 35, 39, 114, 143, 152, 169, 174, 178, 204, 207
Hereford bookseller, 82, 83
Herford, John, 149
Herolt, John, Sermones discipuli, J. Notary, 1510, 143
Heron, John, 184
Hertzog de Landoia, Joh., 91-93
Heywood, J., Gentleness and Nobility, J. Rastell, 185; Johan the Husband, Pardoner and the Friar, Play of Love, Play of the Weather, W. Rastell, 186
Hieronymus de Sancto Marcho, De universali mundi machina, Pynson, 161
Higden, R., Polycronicon, Caxton, 13; Treveris for Reynes, 1527, 199
Higman, J., 18, 205
Higman and Hopyl, 87
Hillenius, Michael, 148, 176
Hilton, W., Scala perfectionis, J. Notary, 1508, 143
History of Jacob, J. Skot, 150
Hoe, Robert, 16, 136
Hoff, Upright, 228
Holder, Robert, 201
Holkham Library, 26
Hollybush, John, 225
Holt, J., Lac Puerorum, A. van Berghen, 91, 216; J. van Doesborch, 220
Holwarde, Thomas, 201
Homiliarius (? Cologne, ab. 1475), 73
Hopyl, Wolfgang, 84, 87, 95, 96, 194-196, 205, 218
Horae, Paris editions, 84-86; undated editions, 85; J. Poitevin, 86
Horae, Sarum: number of editions, 85; Caxton, 17, 21, 33; Leeu, 80;
Machlinia, 48, 49, 109; Notary, 38, 39; C. van Ruremond, 226; W. de Worde, 27; Venice, 1494, 91; Paris, 1498, 96; 1506, 232; 1507, 194; Paris, 1510, 194; Paris, 1532, 1533, 1534, 204; Rouen, 1536, 204; Antwerp, 1530, 223
Horologium Devotionis, Zel, 142
Horse the Shepe and the Goose, Caxton, 10; W. de Worde, 22
Howleglas, 89; J. van Doesborch, 220
Hundred mery tales, J. Rastell, 184
Hunte, Thomas, 98
Hunterian Museum, Glasgow, 19, 64, 155
Huvin, Jean, 37, 38
Hylton, W., Scala perfeccionis, W. de Worde, 26
Hymni cum notis, C. van Ruremond, 226
Hymns and sequences, J. Notary, 143
Imitatio Christi, Pynson, 114, 160
Imposition, wrong, instance of, 50
Indulgences, 104, 106; Caxton, 12, 19; Lettou, 12, 43, 108
Infancia Salvatoris, Caxton, 9
Informatio Puerorum, Pynson, 69
Information for Pilgrims, W. de Worde, 28
Initial letters, 93, 142; filled in by hand, 51
Inner Temple Library, 39
Innocent VIII., 55
Institution of a Christian Man, T. Berthelet, 1537, 180
Interlude of the four elements, J. Rastell, 185
Interlude of women, J. Rastell, 185
Introductorium linguae latinae, W. de Worde, 28
Ipswich, 228
Jacobi, Henry, 105, 108, 148, 194-199, 232; bindings, 119, 197, 198
Jacobus, illuminator, 112
Jean le Bourgeois, 169
Jeaste of Sir Gawayne, J. Butler, 152
Jehannot, Jean, 96
Jerome of Brunswick, Boke of Distillacyon, Andrewe, 155, 221
Joannes de Lorraine, 82
John of Aix-la-Chapelle, 98
John Rylands Library, 26, 30, 53, 55, 68, 84, 161, 162.
See also Althorp Library
Johnson, Maurice, 152
Joye, G., 229, 230
Justice of Peace, R. Copland, 1515, 147
Kaetz, Petor, 222, 226-7
Kalendar of Shephardes, Pynson, 1506, 161
Kamitus, Treatise of the Pestilence, Machlinia, 53
Katherine of Aragon, 159
Kay, J., trans. Siege of Rhodes, 45
Kele, Thomas, 184
Kempe, Adriaen, 231
Kempe, Margerie, 132
Kendale, John, 43
Kerver, Thielman, 171, 205
Kerver, Thielman, Widow of, 204
Keyser, Martin de, 153
King Apolyn of Tyre, W. de Worde, 1510, 7, 136, 146
King’s bookbinder, 181
King’s printers, 133, 158, 162, 169, 170, 171, 175, 177, 178, 181
King’s stationer, 169
Kinnaird Castle Library, 81
Knight Paris and Fair Vienne, Caxton, 16
Knoblouch, Johann, 211
L., R., bookbinder, 233
Lambertus de Insula, 111
Lambeth Palace Library, 4, 61, 92, 162
Landen, John, 142
Langton, William, 110
Langwyth, Agnes, 177
Lant, Richard, 155, 233
Lauret, Giles, 235
Laurentius of Savona, Rhetorica Nova, Caxton, 10
Lauxius, David, 96
Lecomte, Nicholas, 95-97;
bindings, 116
Leeu, Gerard, 36, 78, 80, 88-91, 215
Lefèvre, R., History of Jason, 88
Legenda Francisci, Barbier for Jacobi, 195
Legenda, Sarum, 18
Legrand, J., Book of good manners, W. de Worde, 36
Leicester, Earl of, 26
Leland, John, 156
Le Roux, Nicolaus, 204
Le Talleur, G., 55, 57, 59
Lettou, John, 11, 41-44, 130; bindings, 108; with Machlinia, 44-47, 51
Levet, Pierre, 84
Lewis, J., Life of Caxton, 39
Liber Assisarum, J. Rastell, 184
Liber Equivocorum, Baligault, 84; Paffroed, 79; Pynson, 63
Liber Festivalis. See Mirk, J.
Liber Synonymorum, Martens, 1493, 79; Hopyl, 1494, 84, 95; Pynson, 1496, 63
Lidgate, J., Assembly of the Gods, 15; Chorle and the Birde, 10, 16; Falle of Princes, Pynson, 1494, 62; Horse, Shepe, & Ghoos, Caxton, 10; W. de Worde, 32, 37;
Life of our Lady, Caxton, 14; Sege and Destruccyon of Troye, Pynson, 1513, 163
Life of ... Charles the Great, Caxton, 16
Life of Christ, R. Redman, 175
Life of Hyldebrande, W. de Worde, 138
Life of Petronylla, Pynson, 64
Life of St Katherine, W. de Worde, 24
Life of St Margaret, Pynson, 61
Life of St Wenefrede, Caxton, 15
Life of Virgilius, J. van Doesborch, 220, 221
Lily & Erasmus, De octo orationis partium constructione, Cambridge, 125
Lily, W., Grammar, H. Pepwell, 1539, 149
Lily, W., Introduction of the Eight parts of Speech, T. Berthelet, 181
Lincoln Cathedral Library, 49, 132
Linton, W. J., 13
Litill, Clement, 81
Littleton, Sir T., Tenores Novelli, Letton and Machlinia, 44, 46; Tenures, Machlinia, 48; Pynson, 57, 173; Redman, 173
London: introduction of printing, 11, 41; bindings, 102
Louvain: printing, 5, 77, 80, 219; binding, 111
Lucianus, Necromantia, J. Rastell, 184
Luft, Hans, 228
Lugo, Peregrinus de, Principia, Pynson, 1506, 69, 161
Lumley, Lord, 14
Lyndewode, W., Constitutiones Provinciales, W. Hopyl, 1506, 194, 197, 205; Constitutions, R. Redman, 1534, 176
M., I., border-piece, 176
Maas, Robert, 139
MacCarthy, Count Justin, 73, 74, 162
Macé, Robert, 206
Machlinia, W. de: with Lettou, 44-47; alone, 47-56, 77, 109, 130; bindings, 108
Machyn, Henry, 183
Madan, F., 2, 98
Madden, J. P. A., 95
Magdalen College School, 79
Magna Charta, R. Redman, 1525, 173
Malory, Sir T., Morte d’Arthur, Caxton, 16; W. de Worde, 30
Manchester. See John Rylands Library
Maudeville, Sir J., Travels, W. de Worde, 1499, 32; Pynson, 64
Manipulus Curatorum, W. de Worde, 1502, 132
Mansion, Colard, 5, 6
Manual, Sarum, B. Rembolt, Paris, 86; Rouen, 1500, 82; Pynson, 1506, 161; C. van Ruremond, 1523, 222, 226; for M. Dotier, 1543, 235
Manual, York, W. de Worde, 1509, 136, 212
Marcant, Nicole, 84
Marchant, John, 204
Marsh Library, Dublin, 143, 234
Marshall, William, 203, 204
Martens, Thierry, 79
Martinus de Predio, 112
Martynson, Simon, 139
Mary of Nemmegen, J. van Doesborch, 220
“Master of St Erasmus,” engraver, 142
Maydeston, C., Directorium sacerdotum, Caxton, 9; Leeu, 80; Pynson, 70, 71, 159, 161
Maynyal, George, 17
Maynyal, William, 17, 18
Medwall, H., Interlude of Nature, W. Rastell, 186
Merry gest ... Johan Splynter, J. Notary, 144
Merry jests, J. Rastell, 184
Mery geste of a Sergeaunt and Frere, J. Notary, 145
Meslier, Hugo, 161
Metal engravings, 26, 65, 142
Middleton, William, 124, 125, 176
Miraculous work ... at Court of Strete in Kent, 151
Mirk, J., Liber Festivalis, Caxton, 14, 105; Hopyl, 96; Morin, 80, 82; Notary, 38; Pynson, 61, 62; Ravynell, 83; W. de Worde, 25, 62, 83
Mirror of Christes Passion, R. Redman, 175
Mirror of Consolation, W. de Worde, 28
Mirror of Golde, 1522, 137, 150
Mirror of the Life of Christ, Pynson, 1503, 161
Mirror of the World, Caxton, 12; L. Andrewe, 140, 156
Mirrour of Our Lady, R. Faques, 1530, 172
Missal, Sarum (? Basle, ab. 1486), 78; Maynyal for Caxton, 1487, 17, 80, 81, 84; M. Morin, 1492, 80, 81; Hertzog for Egmont, 1494, 92, 93; Notary and Barbier, 1498, 38; Pynson, 1500, 68, 159; Higman and Hopyl, 1500, 87; Jean du Pré, 1500, 87, 206; Birckman and Cluen, 1504, 217; Pynson, 1504, 161; Violette, 1509, 207; W. de Worde and R. Faques, 1511, 171; C. van Ruremond, 1527, 223; for W. de Worde and M. de Paule, 207
Missal, York, 1530, 206
Modus tenendi unum hundredum, R. Redman, 174
Montaigne, M. de, 164
Montpellier, Library of Faculty of Medicine, 103 Moore, John, bp of Ely, 8
More, Sir Thomas, 158, 183; Works, 1557, 186; Apology, 175, 180; Debellacyon of Salem and Bizance, 180 Morgan, J. P., 106
Morin, Martin, 80-82, 205-6
Morin, Michael, 206
Morton, Cardinal, 68, 159
Musée Plantin, 80
Music. See Book of Songs, 138
N., H., bookbinder, 233
N., I., border-piece, 176
Natura Brevium, R. Redman, 175
Necessary Doctrine and Erudition, 1543, 180
Necton, Robert, 224
Nele, Richard, 193
Newton, Lord, 17
Nicholson, James, 208
Nicholson, John, 225
Nicodemus Gospel, J. Notary, 142; J. Skot, 150-1; W. de Worde, 134
Norwich binding, 108
Notary, Julian, 31, 33, 129, 131, 173; at Westminster, 37-40; at London, 141-6; bindings, 119, 145, 232; device, 37-8; method of dating, 135, 141
Nova Festa, Machlinia, 54; Pynson, 61, 65
Nova Rhetorica, St Alban’s, 1480, 52
Nova Statuta, Machlinia, 48, 51
Novimagio, Reginaldus de, 74
Nowell, bookbinder, 107, 139, 140
Nut-browne Maide, 151, 215
O., R., bookbinder, 233
Of the newe landes, J. van Doesborch, 220
Offor collection, 39
Oliver, Reginald, 233
Oliver of Castile, W. de Worde, 1518, 137
Olivier, Petrus, 82, 205
Orchard of Syon, W. de Worde, 1519, 137
Ordinale, Sarum, Caxton, 9, 22
Ordynaunce ... Kynge’s Eschequier, Middleton, 124
Origen, De beata Maria Magdalena, W. Faques, 170
Ortus Vocabulorum, 194, 197
Os, Govaert van, 30, 33
Osborne, Thomas, 9
Osterley Park Library, 16
Oswen, John, 228
Ovidius, Metamorphoses, 14
Owen, David, 193
Oxford libraries:
Bodleian, 10, 21, 25, 28, 58, 59, 61, 68, 81, 82, 83, 90, 95, 106, 108, 112, 132, 153, 154, 180, 198, 199, 210, 212, 216, 231, 232
Brasenose College, 80
Corpus Christi College, 49, 92, 112, 115, 139
Merton College, 8
New College, 17, 125, 196