Norwegian Journal of development of the International Science No 46/2020 RESEARCH ON THE DEVELOPMENT OF THE COMPOSITION AND TECHNOLOGY OF PREPARATION OF SPECIES FOR THE TREATMENT OF HELMINTHIASIS OF THE DIGESTIVE SYSTEM
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Semchenko K. PhD of Pharmacy, Associate Professor of Department of Pharmaceutical Technology of Drugs, NUPh Vyshnevska L. Doctor of Pharmacy, Professor, Head of Department of Pharmaceutical Technology of Drugs, NUPh Abstract Helminthiases of the digestive system are the most numerous group of invasive diseases on the territory of Ukraine. In order to expand the range of drugs for the third stage of treatment of intestinal helminthiasis (elimination of the consequences of the disease and restoration of the patient's body), a composition was proposed and a technology for preparing an anthelmintic collection based on medicinal plant materials was substantiated. Keywords: helminthiasis, species, technology, plant raw material Helminthiases is the worldwide healthcare problem Introduction. According to the WHO, parasitic diseases in the world affect about 4.5 million people [5, 7, 8]. According to official statistics, 300-400 thousand cases of helminthiasis are registered in Ukraine every year, 80% of them in children [11]. Although, according to some epidemiological studies the incidence of the population of Ukraine is 2 million cases annually [1, 5]. Even with an imperfect accounting system, the annual incidence of helminthiasis in Ukraine reaches 1333 cases per 100 thousand population [3]. The main stages of the clinical course of intestinal helminthiasis are: 1. Acute. Manifested in the form of general allergic and toxic reactions. 2. Latent. Usually not accompanied by clinical manifestations. 3. Chronic. Clinical manifestations are individual. 4. Complications [3, 10]. Pharmacotherapy of helminthiasis usually consists of the following stages: • preparatory (often involves taking antihistamines), • etiotropic treatment, • correction of the consequences and complications of the disease. It is also important to follow the rules of nutrition [3]. The use of medicinal plants is the fundamental basis of folk medicine that covers the experience of many generations and is the basis for the creation of many medicines. Helminthiases treatment is not an exception. Foreign experience of helminthiases treatment does not recommend using herbal remedies at any stage of therapeutic scheme, including complementary therapy. However, research on the anthelminthic action of plant extracts are carried out. For example, in the EU
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SPU – State Pharmacopoeia of Ukraine
and the UK elfwort is recommended as anthelmintic remedy [9]. In Asian countries herbal remedies, including those for helminth infestations treatment, are extensively used and studied. Chinese traditional medicine uses hundreds of different medicinal plants. Pumpkin seeds (Cucurbita moschata Duch) and day-lily (Hemerocallis thumbergii) deserves special attention in helminthiases treatment, as their anthelminthic activity has been clinically proven [2, 4, 9]. The active study of anthelminthic activity of plants takes place in India. The greatest attention is given to such plants extract as Swietenia Mahagoni, Acalypha indica L., Euphorbia hirta, Piliostaigma thonningii, Butae monosperma, Cucurbita maxima, Punica granatum, Capparis decidua, Capparis spinosa, Anacardium occidentalem, Mimusops elengi bark, Cleome icoosandra, Zingiber officinalis, Piper longum, Trychyspermum ammi, Acorus calamus, Glycyrrhiza glabra, Cuminum cyminum, Saussurea lappa [2, 4, 6, 9]. The purpose of this work is to substantiate the composition and develop a technology for collecting anthelmintic drugs based on medicinal plant materials. Materials and methods. The research objects were such medicinal plant raw material as tansy flowers (No. UA / 7116/01/01), wormwood bitter herb (SPU1 2.0, pp. 428-430), centaury herb (UA / 8472/01/01), wormwood flower (Specification), buckthorn bark (SPU 2.0, p. 360-361), elecampane rhizomes with roots (No. UA / 5682/01/01), dandelion herb with roots (SPU 2.0, p. 364), ginger rhizomes (SPU 2.0, p. 336), valerian rhizomes with roots (SPU 2.0, pp. 257-260), chamomile flowers (SPU 2.0, pp. 445-448). Results. On the basis of the data of the previously conducted analysis of the herbal remedies used in the treatment of intestinal helminthiasis [9], the composition of the species, which maximally reflects the needs of the patient’s body at the 3rd stage of treatment, was proposed (Table 1).
