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OCTOBER 2013 • Vol. 19 No. 8

New York Society of Cosmetic Chemists

www.nyscc.org

A Memorable Formulation Experience

…by Paul Thau

Development of an Innovative “Petrolatum Hydrating Aerosol Foam” that was Made Possible by Contributions from Individuals with Diverse Skills

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arly in my cosmetic industry career, several dermatologists, particularly Dr. Albert Kligman, had endorsed the use of petrolatum as a particularly effective skin hydrating and protective agent for patients experiencing extremely dry and scaly skin. Dr. Kligman frequently stated at professional meetings that the first company to overcome the cosmetic inelegance of petrolatum without altering it’s moisturizing efficacy would have a breakthrough product for routine cosmetic use.

Development of a Petrolatum Hydrating Aerosol Foam I was pleasantly surprised during the mid-1980’s when a colleague representing Alcolac Chemical informed me that his firm had been able to develop a fluid emulsion containing 40% petrolatum USP (“Vaseline” grade). This was indeed a development that defied my intuitive expectation. Fortuitously, an R&D colleague

of mine was able to test this 40% petrolatum lotion vs. Vaseline grade petrolatum by the classical Kligman Regression Test procedure with a dry skin clinical panel for moisturizing efficacy. The results indicated equal efficacy. However, the 40% petrolatum lotion was also judged by the panelists to have tacky application properties and therefore was not considered to be cosmetically acceptable. In the laboratory, I found the 40% petrolatum lotion to be unstable when I attempted to dilute it with water to reduce the concentration of petrolatum. Since the supplier had not provided me with the quantitative composition of this lotion, I embarked upon developing my own emulsion using a range of petrolatum levels from 20% to 30%. I also decided to include 5.0% cyclomethicone and 3.0% DRY FLO™ to improve application and sensory properties. The quantitative formulation chosen with the best stability and application aesthetics is shown below: Table I. Petrolatum emulsion concentrate Ingredient Water Petrolatum USP Cyclomethicone Aluminum starch octenylsuccinate Steareth-2 Steareth-20 Imidazolidinyl urea Methylparaben Propylparaben Carbomer 941 Triethanolamine Sodium cetyl-stearyl sulfate Cetyl alcohol (viscosity modifier) Disodium EDTA

Conc. (% w/w) 68.55 20.00 5.00 3.00 1.73 0.58 0.30 0.20 0.15 0.12 0.12 0.10 0.10 0.05 (Continued on page 6)

NYSCC CHAPTER MEETING • OCTOBER 3rd Pleasantdale Château, West Orange, New Jersey


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2013 NYSCC BOARD OF DIRECTORS & PROGRAM CHAIRS CHAIR

Steve Herman (973) 479-5702 steveh50@optonline.net

CHAIR-ELECT

Steve Neidenberg (815) 337-2500 sneidenberg@ritacorp.com

TREASURER

Sonia Dawson sonia.dawson@croda.com

SECRETARY

Kim Burch (215) 320-1573 Kim.Burch@elementis.com

ADVISOR

Brian Hom (973) 345-8600 x3430

HOUSE

Jenna Jelinski (201) 396-8431 jjelinski@morretec.com

MEMBERSHIP

Amy Marshall (908) 806-4664 amy.marshall@altana.com

PROGRAM

Cathy Piterski (678) 730-1643 cpiterski@essentialingredients.com

SPECIAL EVENTS

Phil Klepak (973) 265-2869 pklepak@summitresearchlabs.com

SUPPLIERS’ DAY

Danielle Kennedy dkennedy2014nyscc@gmail.com

COSMETISCOPE EDITOR Roger McMullen roger_mcmullen@fdu.edu

COSMETISCOPE ADVERTISING Bret Clark rbclark@ashland.com

COSMETISCOPE EMPLOYMENT

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Urgent Cosmetiscope Announcement!

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n the last several years, the NYSCC Cosmetiscope has evolved into a well respected periodical in the Cosmetic Industry. It is a hallmark of the New York Chapter of the SCC and provides our membership with the latest information on state-of-the-art technology and keeps us abreast of the latest news and information as well as employment opportunities.The New York Chapter’s executive committee has decided to eliminate the printed edition of the Cosmetiscope. Effective January 2014, you will no longer be receiving the Cosmetiscope in the mail. Instead, look for e-mail blasts, postings on social media, and the NYSCC website (www.nyscc.org) for updated information on chapter events. If you would like to comment, or petition to continue to receive the printed edition of the newsletter—along with its world class technical articles—coming to your home or place of work, contact the Cosmetiscope editor, Roger McMullen, at : roger_mcmullen@fdu.edu.

Members count! It is critical that you make your voice heard if you want to save the Cosmetiscope.

2014 NYSCC Two-day Rheology Symposium March 19-20 Princeton University • McDonnell & Jadwin Buildings Featuring: • Half-day Cosmetic Rheology course by Dennis Laba • Half-day Rheology Modifiers course by Robert Lochhead • Presentations by internationally renowned experts in rheology including: T.J. Lin, Manfred Wilhelm, Robert Prud’homme, and Hemi Nae. • Poster technology session • Rheology instrumentation demonstrations • Student poster session For more information contact Joe Albanese at j.albanese@3vusa.com.

Guojin Lu glu@ashland.com

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NYSCC OCTOBER CHAPTER MEETING

Safety Assessment and Cosmeticovigilance

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Pleasantdale Château, West Orange, NJ October 3, 2013 • 4:00 – 6:30 p.m.

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harmacovigilance is the science of collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products. The pharmaceutical industry is obligated to collect reported complaints from patients, healthcare providers, medical literature, regulatory entities, and industry. Such reporting may include lack of efficacy, medication errors such as overdose, and misuse or abuse of a drug. In fact, in order to market a pharmaceutical product in most countries, adverse event data received by the license holder (usually a pharmaceutical company) must be submitted to the local drug regulatory authority. Similarly Cosmeticovigilance is the collection and analysis of adverse effects of cosmetic products. The FDA had instituted “MedWatch” a program for the reporting of adverse effects due to the use of cosmetic and personal care products. “Even though these products are widely used, most don’t require FDA approval before they are sold in stores, salons, and at make-up counters,” says Linda Katz, M.D., Director of the agency’s Office of Cosmetics and Colors. “So, consumers are one of FDA’s most important resources when it comes to identifying problems.” Katz says consumers should contact the FDA if they experience a rash, hair loss, infection, or other problems, even if they did not follow product directions. The FDA also wants to know if a product has a bad smell or unusual color, which could signal contamination, or if the item’s label is incomplete or inaccurate. In recent decades, our industry gradually has focused more and more on studying the safety of ingredients and finished formulations. Known regulation initiatives such as REACH, the 7th amendment, the global watch for the 3R’s (Reduction, Refinement and Replacement of animal testing) brought about immense activity to find ways to ensure the safety of products. We are still struggling with finding the right “recipe” to follow when testing for safety and look for a simple, harmonized approach of evaluation. Toxicology, however, cannot be generalized. It must be customized for each and every raw material and/or formulation based on a variety of factors. How to approach safety testing in such an environment? What path do we choose that will reduce chances of reported adverse reactions and be compliant with changing regulations, and minimize litigation risk? This unique mini-seminar is put together to clarify key outstanding issues and educate on potential paths to choose. Three experts will take part in this meeting. Dr. Pushpa Rao, Sr. Manager Global product Safety/NAM Regulatory Affairs at Energizer Personal Care, will begin with a global overview on current requirements and methodologies. Dr. Nava Dayan, Pharmaceutical, Cosmetic, Personal Care Industry Expert, will delve into the specific limitations associated with RIPT. Trenton Norris, Senior Partner at Arnold & Porter LLC, will discuss issues and compliance to California’s Proposition 65 to prepare for possible litigation.

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Specialty Silicones t Specialty Esters Delivery Systems Skin & Hair Moisture Complexes EXSYMOL S.A.M.: Silanols t Peptides GELYMA: Marine Cell Actives 201-825-8800 t www.biosiltech.com

Laura Spaulding, Ph.D. NYSCC October Event Chair

A t t e n t i o n

M e m b e r s

Unemployed and Emeritus members may continue to attend monthly meetings free of charge. Please contact the registration booth upon arrival. Unemployed members may also continue their membership free of charge by submitting the renewal form with unemployment details. Please remember that the SCC Employment Service is here to assist you. Contact: Guojin Lu • E-Mail: glu@ashland.com

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EDUCATIONAL HOUR SPEAKERS

24/7 Online Ingredient Information:

www.floratech.com

Label The Natural Solution i

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In the New York SCC Region:

Essential Ingredients Michael Manning 201.576.9382 mmanning@essentialingredients.com

Speaker: Nava Dayan, Ph.D. Topic: RIPT Testing—A True Assessment of Skin Adverse Reactions? Date: October 3, 2013 • 4:30 PM Location: Pleasantdale Château, West Orange, NJ

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mong the reported adverse effects to cosmetics is skin rash (irritation) and allergic reaction (sensitization). Repetitive Insult Patch Test (RIPT) is aimed to detect primary irritation and type 4 sensitization. But is the RIPT sufficient in covering the array of potential incidences with exposure? In this presentation we will discuss skin irritation and sensitization reactions in skin, list key advantages and limitations of RIPT, and identify gaps that if addressed may assist in producing safer products.

Biography:

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r. Nava Dayan is an independent consultant with 24 years of experience in variety of aspects of skin care; offering a wide range of services for the pharmaceutical, cosmetic, and personal care industries as well as research entities, regulatory agencies, and academic institutions. Her primary service focus is on innovation, bridging technology to industry, identifying paths in product development, efficacy claims, safety assessment, skin absorption, increased efficacy, and strategies to attenuate adverse effects. Nava’s area of expertise spans skin aging, skin inflammatory disorders, delivery systems for enlargement of therapeutic index, natural ingredients and formulations, skin’s innate immunity and barrier integrity, biochemical paths analysis, and skin research of toxicological endpoints and their assessment. Dr. Dayan holds a Bachelor’s degree in Pharmaceutics, Master’s degree in Pharmaceutics and Pharmacology, and a Ph.D. in Pharmaceutics. All degrees were obtained from the Hebrew University in Jerusalem.

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877.700.0302 • www.chemsil.com

Speaker: Pushpa Rao, Ph.D. Topic: Product Safety Date: October 3, 2013 • 5:00 PM Location: Pleasantdale Château, West Orange, NJ

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he presentation will begin with a brief description of the current landscape of product safety with emphasis on the United States, Canada, and new requirements in the European Union. Key points will include ingredient safety considerations and restrictions, and cautionary labeling. Discussion will also include a review of recognized test methodologies with particular attention to safety requirements around the world.

Biography:

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ushpa Rao is Senior Manager of Regulatory Affairs and Product Safety at Energizer Personal Care based in New Jersey. Energizer Personal Care markets two leading sunscreen brands, Banana Boat and Hawaiian Tropic, as well as Wet Ones Anti-bacterial wipes, Edge and Skintimate Shave preps, Playtex tampons, and Infant Care articles. Pushpa has spent the last twelve years in Regulatory Affairs and Product Safety in the Personal Care industry after leaving a teaching position at Loyola University in Chicago. She served as chairperson of the Safety Regulatory Toxicology Committee with the Personal Care Products Council. She is a Board certified toxicologist and certified in U.S. regulatory affairs. She completed her doctoral work in Organic Chemistry at University of Illinois in Chicago.

NYSCC MONTHLY MEETING REGISTRATION: • Online: www.nyscc.org • For questions, please contact: Jenna Jelinski at jjelinski@morretec.com or (201) 396-8431.

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M O N T H LY C H A P T E R M E E T I N G Speaker: Trenton Norris, J.D. Topic: Proposition 65: Pre-Litigation Strategies Date: October 3, 2013 • 6:30 PM Location: Pleasantdale Château, West Orange, NJ Open registration: 4:00 PM Educational Hour Starts: 4:30 PM • Dinner: 5:30 PM

CHAPTER MEETING COST: Pre-registered SCC members: $35 ($70 at door) • Pre-registered non-SCC members: $75 ($110 at door) Students: $10 ($50 at door) • Emeritus: Free ($40 at door) Register online at: www.nyscc.org.

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alifornia's Proposition 65 has bedeviled scientific and regulatory professionals for over 25 years. The law is characterized by its ever-changing list of chemicals, its lack of numerical standards, and its variety of open, but fundamental, questions. In this presentation, Trent Norris, a leading Proposition 65 defense attorney, will (1) review trends in chemical listings, focusing on chemicals of interest for personal care products; (2) detail the scientific methods used to develop threshold levels (NSRLs and MADLs) for chemicals; and (3) walk through an example of how to assess exposures for personal care products in order to evaluate compliance and prepare for possible litigation.

Biography:

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rent Norris, a senior partner in the firm's San Francisco and Silicon Valley offices, litigates complex scientific and technical disputes in the areas of consumer protection, advertising, product liability, product safety, environmental, and food law. Mr. Norris' clients are primarily manufacturers and retailers of everyday products and services. His cases have involved diverse products, technologies, and industries, including dietary supplements, cosmetics, restaurants, hotels, amusement parks, plumbing products, medical devices, soft drinks, glassware, snack foods, vaccines, home electronics, paints, motor vehicles, pharmaceuticals, and batteries. He often works with trade associations and joint defense groups in these industries. Mr. Norris has advised and defended hundreds of companies regarding California's unique toxics and labeling law, Proposition 65, and California's expansive consumer protection laws. Chambers USA (2012) notes that he “is renowned as one of the region’s leading experts in toxic tort and Proposition 65 matters. Clients particularly laud his ability to focus on the issues at the core of the problems they take him.” Mr. Norris served as the top legislative aide to a U.S. Senator on appropriations, environmental, and transportation issues (1987-89). He was Editor of the Harvard Law Review (1990-92). He headed Arnold & Porter’s San Francisco and Silicon Valley offices from 2008 to 2013, and regularly speaks to law students concerning the economics of law practice.

Directions to Pleasantdale Château, West Orange, NJ 757 Eagle Rock Avenue, West Orange, NJ 07052 • (973) 731-5600 • I-280 West: If traveling west on I-280, take Exit 7 (Pleasant Valley Way) toward Millburn/ Verona. Merge onto Pleasant Valley Way/CR-636 toward Verona. Follow Pleasant Valley Way for about 0.8 miles then turn left onto Eagle Rock Avenue/CR-611. After 0.5 miles, you will find the Pleasantdale Château on the right-hand-side of the road. • I-280 East: If traveling east on I-280, take Exit 6 (Laurel Avenue). Turn left onto Laurel Avenue/CR-634. After about 1 mile, turn slightly right onto Eagle Rock Avenue/CR-611. You will travel about 0.2 miles on Eagle Rock Avenue and the Pleasantdale Château will be on the left. • Gardenstate Parkway North: If traveling north on the Gardenstate Parkway, take Exit 145 towards I-280/The Oranges/Newark/Harrison. Follow signs for I-280 West. Follow directions above for I-280 West. • Gardenstate Parkway South: If traveling south on the Gardenstate Parkway, take Exit 145 towards I-280/The Oranges. Follow signs for I-280 West. Follow directions above for I-280 West. • NJ Turnpike North: If traveling north on the NJ Turnpike, take Exit 15W for I-280 West in the direction of Newark. Follow directions above for I-280 West. • NJ Turnpike South: If traveling south on the NJ Turnpike, take Exit 15W for I-280 West in the direction of Newark/Kearny. Follow directions above for I-280 West. V V O O L L U U M M E E

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A Memorable Formulation Experience

Innovation for Hair & Skin

croda.com/na/pc

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The formulation shown in Table I exhibited good flow properties as well as satisfactory stability at elevated temperatures, room temperature, and freeze/thaw conditions. My conventional expectation was that the Marketing department would have been interested in marketing this formulation in a plastic bottle with a pump dispenser. However, to my surprise, they insisted in having this petrolatum emulsion concentrate delivered as a foam/mousse. The vogue at that time (the late 1980s) was for aerosol foam delivery systems to be used for hair conditioning and styling products, but rarely for skin treatment products. I reviewed the feasibility of dispensing this lotion as foam utilizing the basic hydrocarbon propellants (such as A-46) found in shaving cream foams. My judgment was that this request had a low probability for success because the emulsion concentrate contained 20% petrolatum with less than 2.0% of nonionic emulsifiers. Since I had learned from challenging projects in the past not to reject “blue sky” requests summarily, I decided to visit a local aerosol facility to determine if my judgment was correct or not. Since Cosmair R&D (my place of employment) did not have an aerosol laboratory at that time, I arranged to meet Mac Bhuta, Director of Aerosol Technology at an aerosol facility located in Linden, NJ. During our initial discussions, Mac also expressed skepticism about the feasibility of obtaining satisfactory foam with our emulsion concentrate containing a high concentration of petrolatum. Nevertheless, he agreed to proceed with a formulation utilizing conventional aerosol propellants.

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(Continued from page 1)

Several aerosol foam trials with various concentrations of propellant blend A-46 were deemed to be unsatisfactory because the foams were loose and coarse. However, as I was about to leave, Mac Bhuta thought of an alternate propellant blend, Freon 152A/A17 (60/40), to use since it possesses special properties because of it high density. To my surprise and exhilaration, his suggestion proved to be “on target” in producing a fine textured foam with good consistency. We finalized our formulation with a ratio of 93% petrolatum emulsion concentrate and 7.0% propellant 152A/A17 (60/40). A consumer panel test conducted two months later documented that this “Petrolatum Body Mousse” composition delivered on its promised end benefits of moisturizing, protecting, and leaving the skin soft and smooth. Lancôme, Inc. commercialized this product in 1990 as Crème Mousse Hydratant. This product remained on the market for over eight years. Other foam/mousse skin care products based upon this patented technology were subsequently developed.1 Overall, I was proud of this innovative development, primarily because of the positive

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feedback that I received related to this products efficacy in treating dry skin and winter itch. However, I gratefully acknowledge that this development would not have come to fruition without the contributions from several other individuals, particular those of Mac Bhuta. This experience reinforced for me the essential role that effective collaborations between individuals with diverse skills and expertise have for the development of innovative products.

Update on Safety and Efficacy of Petrolatum USP for Cosmetic and Dermatological Applications Safety: Some beauty companies are promoting petrolatum alternatives because of the trend to use natural emollients and due to unsubstantiated safety concerns related to polycyclic aromatic hydrocarbon (PAH) content in refined petrolatum. However,

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cosmetic and pharmaceutical petrolatum grades meeting United States Pharmacopoeia (USP) standards are highly refined and must meet all of the standards, including limits for PAHs. While no studies have ever shown a direct link between petrolatum and cancer, the European Union has placed numerous poorly refined grades of petrolatum on a list of dangerous substances. The European Union only allows refined grades of petrolatum, which meet stringent standards for PAH content, to be used in cosmetic and pharmaceutical products. Current information related to Petrolatum and Regulatory Requirements can be found at: http://calumetspecialty.com/pdf/articles/NPRA2003 _Pet_Regulations.pdf. Efficacy: In a study by R. Ghadially and coworkers, barrier recovery was measured in petrolatum treated versus untreated skin sites after acetoneinduced barrier disruption in human volunteers.2 In addition, petrolatum was localized within the corneum with tracers and ruthenium tetroxide staining, which allowed visualization of the penetration depth of petrolatum and its relation to intercellular membrane structures. Overall, they found that petrolatum accelerated, rather than impeded, barrier recovery. Moreover, petrolatum was present within the interstices at all levels of the stratum corneum, where it replaced intercellular bilayers. Thus, it was concluded that petrolatum neither forms nor acts like an epicutaneous impermeable membrane; instead, it permeates throughout the stratum corneum interstices, allowing normal barrier recovery despite its occlusive properties.

The soul and science of beauty. www.evonik.com/personal-care

■ REFERENCES 1. United States Patent 4,981,677, “Petrolatumcontaining aerosol foam concentrate,” January 1, 1991. 2. R. Ghadially et al., J Am Acad Dermatol, 26, 387396 (1992).

SCC Continuing Education October 23-24 November 14 November 14-15

Introduction to Polymer Science and its Applications in the Cosmetic Industry Skin Diseases and Dermatopharmacology Regulatory Update

December 11

Molecular Biology, Gene Expression for the Cosmetic Chemist

December 11

Low-energy Emulsification

For more information, visit www.scconline.org.

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Nomination for 2014 Executive Board Officers ■ Chair Elect – Kim Burch ■ Treasurer Elect – Marie Thadal ■ Secretary – Jenna Jelinski Any further nominations please send to: Steve Neidenberg Nomination/NYSCC Chair Elect 2014 Rita Corporation 850 S. Route 31 Crystal Lake, IL 60014

T R I - P R I N C E T O N

E V E N T S

Hair & Scalp Biology Workshop November 11 This one day intensive workshop on hair and scalp biology, taught by leading hair biologist, Dr. Gillian Westgate, is intended to organize and advance hair and scalp biology as an integral component of hair care product development.

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Rossow USA Inc. Distributors of Smart Cosmetic Ingredients

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Ingredients ffor or Quality Ingredients ŽƐŵĞƟĐƐ ŽƐŵĞƟĐƐ ĞƌŵŽͲĐŽƐŵĞƟĐƐ ĞƌŵŽͲĐŽƐŵĞƟĐƐ Phone : 1-855-7ROSSOW Email : contact@rossow-usa.com W eb : www .rossow.fr Web www.rossow.fr

Variations of Hair & Skin November 12-13 This focused international conference will provide a unique platform to discuss variations of both hair and skin due to ethnicity, age, and health, and approaches to design and market innovative products targeted to treat these effects. This year's conference will have a special focus on scalp, underarm, and baby care.

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Measuring Skin & Product Applications November 14-15 Dr. David Moore and Dr. Nik Kollias moderate this two-day hands-on course focused on measurement science and linking these measurements to skin physiology. Included in this workshop are technical discussions on the physiology of skin, anatomy of skin, molecular biology, irritation, inflammation, pigmentation, transport barriers, biophysics, and bio-responses.

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For more information on all three events contact Eleanor Lehman at events@triprinceton.org, or (609) 430-4820; or visit their website at www.triprinceton.org/education.

Make note of it…Cosmetiscope Send news of interest, guest editorials, and comments to: Roger McMullen, Editor E-mail: roger_mcmullen@fdu.edu 8 8

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Save the Date

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June 5, 2014 Poster Competition: Call for Abstracts New York Academy of Sciences • World Trade Center, Building 7 • New York, NY The conference will be held on the top floor of the newly constructed Building 7 of the World Trade Center, home to the New York Academy of Sciences. A concurrent poster session will be judged on originality and innovation relevant to methodologies and the use of antioxidants in skin care. Please send poster abstract submissions by October 31, 2013 to Jenna Jelinski at JJelinski@morretec.com.

Poster Prizes: 1st place $1,500 2nd place $1,000 3rd place $500

Conference attendees will receive a complimentary book:

Antioxidants and the Skin By Roger L. McMullen

Upcoming 2013 NYSCC Events Calendar • For updated NYSCC information, visit us on the web at: www.nyscc.org • For National SCC information: www.scconline.org October 3 NYSCC Monthly Meeting, Pleasantdale Château, West Orange, NJ November 13 Cosmetic Technology Transfer Conference, Renaissance Woodbridge Hotel, Iselin, NJ December 12-13 2013 Annual Scientific Meeting and Technology Showcase, New York, NY

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Employment Opportunities Send employment ads to…Guojin Lu (glu@ashland.com) and Roger McMullen (roger_mcmullen@fdu.edu). Employment listings published in the Cosmetiscope are abridged due to space limitations. 08-02-2013 ■ PERSONAL CARE FORMULATION TECHNICIAN INOLEX, a Philadelphia-based cosmetic ingredient company, seeks an entry-level candidate to develop and prepare prototype formulations under the supervision of the Manager, Personal Care Applications. Principal responsibilities: • Design finished product formulations that can demonstrate the benefits provided by new and existing products to customers, and prepare formulation data sheets and reports for use by Marketing to prepare promotional materials. • Prepare and execute lab protocols, lab procedures, stability testing programs, and validation tests. • Participate in the new product development program and evaluate the application benefits of new prototype products designed and prepared in the R&D labs. • Work with Claims Substantiation to provide mixtures and prototype formulations. • Participate in Claims Substantiation studies. • Assists customers in formulation development and provide input for improving formulations or manufacturing procedures. Analyze customers’ products to determine potential raw material substitution with Inolex products for customer cost savings or performance enhancement. Qualifications: Associate’s degree, preferably in Chemistry or Biology, or equivalent related experience. One to three years of experience in Personal Care formulation development preferred. To apply, please send an e-mail to: apply@inolex.com. _____________________________________________________________ 08-01-2013 ■ TECHNICAL ACCOUNT MANAGER BASF has an immediate opening at the BASF R&D Center in Tarrytown, NY for a Technical Account Manager for biological actives within the Care Creations portfolio. Responsibilities: • Serve as the direct technical contact for regional customers, working globally to collect and distribute information on catalog products as well as customer specific project information. • Provide technical expertise to regional customers and regional key account teams. • Translate customer needs to the technical team and assist in defining project scope. • Support customer projects (concepts/product development) internally, in close cooperation with R&D project leaders and marketing. • Identify product/technical concepts trends and customer demands in the regional market, and propose pertinent technical solutions for biological actives portfolio. • Identify opportunities, projects, and new initiatives with Sales, Marketing, and Technology. Qualifications:

• B.A./B.S. in Science, Biology, or related field with a minimum of 5 years of experience in the skincare industry is required.

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• M.S. preferred. • Cell biology or biochemistry experience preferred. • Scientific knowledge in the field of active ingredients and/or active cosmetic products and scientific claims. • Specific experience in direct customer interaction. • Up to 50% travel. To apply, go to: http://jobs.basf.us/job/Tarrytown-Technical-Account-ManagerTarrytown%2C-NY-Job-NY-10591/2763023/. _____________________________________________________________ 07-24-2013 ■ SALES REPRESENTATIVE Bio-Botanica has an exciting opportunity for a field based sales position covering primarily North America. This is a Northeast based position for someone with 0-3 years experience. The focus of this position is to develop relationships with customers. Our customers range from global cosmetic and personal care companies to one-person start-ups. By providing excellent communications and follow-up, you will be a resource for the customer to uncover unmet needs and find solutions. This position is about detailed development of sales opportunities and requires a strong drive and attention to detail. You will work closely with the technical and marketing groups. Along with the detailed sales opportunity management there are opportunities to sell a full array of standard products. This position’s primary responsibility is to manage a accounts in North America to identify new customer projects that will generate new revenue. Responsibilities: • Manage key accounts in North America. • Promote existing product lines to generate immediate revenue gains. • Act as a resource for the customer by providing technical, sales, marketing, and regulatory support. • Manage strategic projects at key accounts. • Lead the implementation of field level sales strategy and goals. • Analyze and provide feedback on business development opportunities. • Take complete ownership of the sales development process by leading, analyzing, and providing feedback on how to improve. • Have fun while creating success. Qualifications: • 0-3 years of experience selling ingredients in the Personal Care market. • B.S. in Chemistry, Biology, or related field. • Entrepreneurial spirit with a focus on solutions. • Customer focused. • Self-motivated, passionate, outgoing, and organized with an innate drive to succeed. • Extensive travel throughout North America. To apply, contact: Jason O'Neill, Director of Sales at joneill@bio-botanica.com. _____________________________________________________________ 07-17-2013 ■ RESEARCH INVESTIGATOR/SCIENTIST International Flavors and Fragrance (IFF), located in Union Beach, NJ, is seeking a Research Investigator. This position will support the strategic

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mission of the Delivery and Material Technology Team. The individual will be an integral part of a team in conducting cutting edge research to develop and commercialize patentable fragrance and flavor delivery systems with superior performance to support the continued business growth at IFF. Education requirements: The successful candidate will have a Ph.D. in Chemistry, Chemical Engineering, or Food Science, with at least 1-3 years of industrial or academic post graduate research experience. Experience requirements: Seven years related experience with three years of experience managing research projects. Apply at: http://www.iff.com/career-opportunities.aspx Position number=1353-292. _____________________________________________________________ 07-10-2013 ■ PROSPECTIVE SCIENTIST, SKINCARE (PISCATAWAY, NJ) Chanel Inc., a leader in the luxury goods industry, is seeking a Prospective Scientist, Skincare to develop and support long-term research concepts using novel or state of the art technology. This individual is expected to develop innovative and exciting products for a global marketplace as well as seek out and initiate blue-sky projects. Position is technically self-directed. Education requirements: Bachelor’s degree in related scientific discipline required. Master’s degree in related scientific discipline is preferred. Experience requirements: Seven years related experience with three years of experience managing research projects. To apply, please visit: http://ch.tbe.taleo.net/CH01/ats/careers/requisition.jsp?org= CHANEL&cws=1&rid=771 Chanel, Inc. is an Equal Opportunity Employer. EOE M/F/D/V. _____________________________________________________________ 07-02-2013 ■ ACCOUNT MANAGER – ACTIVE INGREDIENTS BASF – The Chemical Co. is searching for an Account Manager located in Northeastern U.S. This position is a home based covering the United States, Canada, and Mexico. The Account Manager – Active Ingredients' primary responsibility is to manage a portfolio of accounts in North America to identify new projects, lead with a collaborative approach, and to grow the sales at these accounts. Principal responsibilities: • Account Management of several large personal care accounts in North America, to develop short- and long-term development projects. • Sell standard product portfolio offerings for quick business gains. • Provide a complete service offering (commercial, technical, marketing, legal, and regulatory) at these accounts. • Identify and influence all decision-making authorities at the customer. • Management of complex development projects with key accounts. • Grow the biological active business at a level above average market growth rates. Qualifications: • Minimum five years of experience selling biological active ingredients in the Personal Care market sector. • B.S in Chemistry, Biology, or related field. • Estimated 50% travel depending on where you live in the territory. • Experience with large, complex, and global Personal Care companies is a plus.

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• Marketing and/or Project Management exposure is also a plus. Apply online at: http://jobs.basf.us/job/Florham-Park-Account-Manager-ActiveIngredients-North-America-Job-NJ-07932/2695315/. _____________________________________________________________ 06-27-2013 ■ ACCOUNT MANAGER Callahan Chemical is a leading independent distributor of a wide variety of materials for use in Personal Care, Flavors & Fragrances, Nutrition, Pharmaceutical, and HI & I. Since 1958, Callahan has maintained strong relationships with customers and world-class supplier/ partners. Callahan currently has an opportunity for an Account Manager in the Northern New Jersey Area. Description: • Manage existing territory sales and promotion of specialty ingredients. • Responsible for sales/profitability growth and new account development. • Ability to build and maintain effective relationships with customers, decision-makers, and influencers, understanding and communicating customer requirements. • Promote and sell company products/services to existing and prospective customers. • Participate in manufacturer training and maintain understanding of product attributes. • Generate sales reports and contribute to budgeting and forecasting. • Participate in appropriate trade association meeting and shows. Qualifications: • Bachelor’s degree or equivalent experience in science/technology or business-related field with a minimum of 3-5 years of related sales experience. • The successful candidate will be dynamic, motivated, organized, and able to work independently. • Excellent presentation, communication, and negotiation skills required. • Local travel required. If interested, please forward your résumé and salary history to: cford@calchem.com. _____________________________________________________________ 06-27-2013 ■ REGULATORY AFFAIRS SPECIALISTS (ALLENDALE, NJ) Playtex, a division of Energizer Personal Care, seeks Regulatory Affairs Specialists in our Allendale, NJ R&D facility. Responsibilities: Provide regulatory support to the commercialization of all personal care product categories, with emphasis on cosmetics and OTC drugs in North America, Latin America, and Asia. Qualifications: • B.S. preferable in Biology, Chemistry, Engineering, or Material Science with 2-6 years regulatory experience. • Sound knowledge of U.S. or other regional cosmetic or drug product registration processes. • Experience with international cosmetic, drug, or device product registration preferred. • Knowledge of FDA regulations governing cosmetics, OTCs, or drugs. Apply online to job #: 33873 (North America); 34196 (Asia) at: http://www.energizerholdings.com/careers/ Pages/default.aspx.

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October 29, 2013 Life Sciences Rutgers Busch Campus LLonza onza PPersonal ersonal Care Care

Recapturing beauty through technology

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Insights Into Skin Product Development Registration: http://www.regonline.com/insightsintoskinproducts Faculty: Joel L. Zatz, Ph.D. Professor Emeritus at Rutgers University David C. Steinberg FRAPS, Steinberg & Associates, Inc. Otto H. Mills Jr., Ph.D., F.C.P. Adjunct Professor, Department of Dermatology, Rutgers Robert Wood Johnson Medical School sensiva® – multifunctional additives designed for your innovation euxyl® – optimum preservation according to your needs

schülke inc. 1-888-267-4220 www.schulke-us.com/cosm

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his is a course for researchers, product developers, and evaluators of skin products. It is a program of the Basic & Applied Dermatology Forum, cosponsored by the Center for Dermal Research and the New Jersey Center for Biomaterials.

Cost

CDR Members $100.00; Non-CDR Members $175.00; RU/UMDNJ Faculty $75.00; Students $50.00

Agenda 7:45 a.m. 8:20 a.m. 8:30 a.m. 9:15 a.m. 10:00 a.m. 10:15 a.m. 11:00 a.m. 11:45 a.m. 12:30 p.m. 1:15 p.m. 2:00 p.m. 2:15 p.m. 3:30 p.m.

Registration Brief Remarks – Introduction – Otto Mills Aspects of Product Quality and Horny Layer Basics – Joel Zatz Skin Delivery and Delivery Systems – Joel Zatz Break Conducting and Interpreting Human Testing – Otto Mills Acne to Xerosis—Changing Paradigms – Otto Mills Lunch Critical Components of Skin Product Formulations – David Steinberg The Changing Regulatory Landscape – David Steinberg Break Workshops on Current Challenges Adjourn

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