NOVEMBER 2013 • Vol. 19 No. 9
New York Society of Cosmetic Chemists
www.nyscc.org
Proteomics in Skin Care— From Fundamentals to Latest Technologies …Nava Dayan and Matthew Kuruc
General Introduction
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he proteome is the entire complement of proteins including the modifications made to a particular set of proteins, produced by an organism or system. Proteins are vital part of the living organism controlling metabolic paths of cells. They serve as receptors, transporters, mediators, enzymes, and network components of extracellular matrix domains. Analogous to the field of gene expression for mRNA analysis, the field of proteomics surveys the presence of proteins. However, unlike gene expression, proteomics can also assess structure, splice variants, post-translational modifications, and interactions with compounds, substrates, and other proteins, affording a much deeper view of functional relevancy towards phenotypic characterizations. In recent years, gene expression analysis has been utilized to study the reactivity of certain treatments to skin. While gene expression provides some mechanistic insights for cells that deviate from normal, it only indirectly infers cellular biochemical cascades, as it is now generally acknowledged that mRNA regulation is not always correlated to protein regulation and function. So, unless gene expression is superimposed with proteomics, clinically relevant features of the phenotype may be misrepresented. In fact, the amount of protein produced for a given amount of mRNA depends on the gene it is transcribed from and on the current physiological state of the cell. The cascading events that further control translation of mRNA to protein and its activation is highly complicated and beyond the scope of this review. Nevertheless, the goal of proteomics is to compare and identify which proteins deviate from homeostasis in their amounts, structures, and interactions with other regulating constituents. While such comprehensive assessments are rarely achieved in proteomics, the field has advanced many new methodologies to efficiently profile subsets of proteomes, or targeted functional or structural surveys to allow faster, cost effective, and more accurate analysis. The selection of such methodologies depends on the hypotheses posed, and biological outcomes to be
Courtesy of Helmholtz Centre for Environmental Research – UFZ, Leipzig, Germany, www.ufz.de.
monitored. If gene expression data is available, that might be a good place to start. While there has been great progress in uncovering gene expression patterns that are clinically informative, and suggest pathway associations with disease or compound-induced modulation, two key challenges remain. The primary challenge is to establish a correlation between the prospective gene markers and their corresponding protein products, especially the subsets most relevant to clinical features of the skin phenotype. A second challenge is to distill this most informative subset of genes to assayable biomarkers that can be readily measured from biological tissues. A variety of (Continued on page 4)
NYSCC COSMETIC TECHNOLOGY TRANSFER CONFERENCE November 13th • Renaissance Woodbridge Hotel, Iselin, NJ
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2013 NYSCC BOARD OF DIRECTORS & PROGRAM CHAIRS CHAIR
CHAIR-ELECT TREASURER
Sonia Dawson sonia.dawson@croda.com
SECRETARY
Kim Burch (215) 320-1573 Kim.Burch@elementis.com
ADVISOR
Brian Hom (973) 345-8600 x3430
HOUSE
Jenna Jelinski (201) 396-8431 jjelinski@morretec.com
MEMBERSHIP
Amy Marshall (908) 806-4664 amy.marshall@altana.com
PROGRAM
Danielle Kennedy dkennedy2014nyscc@gmail.com
COSMETISCOPE EDITOR Roger McMullen roger_mcmullen@fdu.edu
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2014 NYSCC Two-day Rheology Symposium March 19-20 Princeton University • McDonnell & Jadwin Buildings Featuring:
COSMETISCOPE EMPLOYMENT
• Half-day Rheology Modifiers course by Robert Lochhead
Guojin Lu glu@ashland.com
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Members count! It is critical that you make your voice heard if you want to save the Cosmetiscope.
COSMETISCOPE ADVERTISING Bret Clark rbclark@ashland.com
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SPECIAL EVENTS SUPPLIERS’ DAY
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n the last several years, the NYSCC Cosmetiscope has evolved into a well respected periodical in the Cosmetic Industry. It is a hallmark of the New York Chapter of the SCC and provides our membership with the latest information on state-of-the-art technology and keeps us abreast of the latest news and information as well as employment opportunities.The New York Chapter’s executive committee has decided to eliminate the printed edition of the Cosmetiscope. Effective January 2014, you will no longer be receiving the Cosmetiscope in the mail. Instead, look for e-mail blasts, postings on social media, and the NYSCC website (www.nyscc.org) for updated information on chapter events. Meeting announcements in a format identical to the present Cosmetiscope will continue to be mailed. If you would like to comment, or petition to continue to receive the printed edition of the newsletter—along with its world class technical articles—coming to your home or place of work, contact the Cosmetiscope editor, Roger McMullen, at : roger_mcmullen@fdu.edu.
Cathy Piterski (678) 730-1643 cpiterski@essentialingredients.com Phil Klepak (973) 265-2869 pklepak@summitresearchlabs.com
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Urgent Cosmetiscope Announcement!
Steve Herman (973) 479-5702 steveh50@optonline.net Steve Neidenberg (815) 337-2500 sneidenberg@ritacorp.com
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• Half-day Cosmetic Rheology course by Dennis Laba
• Presentations by internationally renowned experts in rheology including: T.J. Lin, Manfred Wilhelm, Robert Prud’homme, and Hemi Nae. • Poster technology session • Rheology instrumentation demonstrations • Student poster session For more information contact Joe Albanese at j.albanese@3vusa.com.
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Cosmetic Technology Transfer Conference
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Wednesday, November 13, 2013 ®
Renaissance Woodbridge Hotel • Iselin, New Jersey
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Specialty Silicones t Specialty Esters Delivery Systems Skin & Hair Moisture Complexes
he fourth annual NYSCC Technology Transfer Conference will bring leaders intechnology transfer together with the cosmetic industry, and will include expert speakers and research posters from across the country.
EXSYMOL S.A.M.: Silanols t Peptides GELYMA: Marine Cell Actives 201-825-8800 t www.biosiltech.com
Keynote Speaker: Jon Gertner CALL FOR ABSTRACTS The NYSCC is accepting abstracts for the research poster session. ■ ABSTRACT SUBMISSIONS Go to : http://www.nyscc.org/cttc_abstract.html. Posters will be accepted by the Conference Review Committee. ■ PRIZES FOR BEST POSTERS: • $5000 First Prize • $2000 Second Prize
• 5 Third Prizes at $1000 each
CONFERENCE SCHEDULE 8:00 – 9:00 a.m. 9:00 – 11:00 a.m.
11:00 a.m. – 3:00 p.m. 3:00 – 4:00 p.m. 4:00 – 4:30 p.m.
Registration, continental breakfast Speakers: Dr. Jose Cordeiro – Singularity University Dr. Robert Lochhead – Formulation Institute SMU Dr. Daniel Strickland – USDA Buffet lunch, posters, networking Keynote speaker Book signing
For further information, go to the conference website, http://nyscc.org/event-registration/?ee=10. Specific questions on poster requirements and other conference inquiries can be directed to: Lara Ahad (lara.ahad@gmail.com) or Art Georgalas (arthurgeorgalas@gmail.com).
Call for Papers
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he Cosmetiscope editorial committee invites all interested parties to submit feature technical articles for publication in the NYSCC monthly newsletter. Authors of feature articles are eligible to win the prestigous NYSCC Literature Award ($1,000) for the best front-page article published during the calendar year. Also, authors receive $200 reimbursement to attend a theatrical performance of their choice. Writing an article for your peers is a very rewarding experience, both personally and professionally, and would reserve your place in NYSCC history. You may choose whatever topic you feel would be interesting to fellow colleagues in our industry. We also welcome any other types of commentaries or articles that may be published in the Career Corner, Technical Tidbit section, or as a Letter to the Editor. Please send correspondence to: roger_mcmullen@fdu.edu.
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Proteomics in Skin Care
24/7 Online Ingredient Information:
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www.floratech.com
Label The Natural Solution i
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In the New York SCC Region:
Essential Ingredients Michael Manning 201.576.9382 mmanning@essentialingredients.com
Courtesy of University of Arizona, Arizona Proteomics Consortium, http://proteomics.arizona.edu.
tools and techniques support such targeted proteomic efforts. When gene expression is not available, direct proteomic analysis of skin is a practical alternative.
Proteomics in Skin Care
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The skin, like all other organs in the body, contains an abundant variety of proteins that function at different levels. From keratins in the stratum corneum, collagen and elastin in the dermis, all the way to extracellular matrix proteins— proteins in the skin are the entities that allow it to maintain its essential functions as a protective immune response organ. Examples of proteomic analyses in skin include: • Barrier function at the stratum corneum identifying changes at the cornified envelop and desmosomal structures. • In the living epidermis, following immunological paths of cytokines, receptors, and transporter expression utilizing cell lines such as keratinocytes, melanocytes, and Langerhans cells. • In the dermis, understanding changes in the skin extracellular matrix foundation (collagen and elastin levels and modifications such as in advanced glycation) in relation to skin aging and wound healing in fibroblast models as well as immune related modifications in mast cells. An example for utilizing proteomics in skin care can be drawn from two studies in which psoriatic skin was studied. In the first study, Ryv et al. conducted proteomic analysis of psoriatic skin tissue for identification of differentially exposed
proteins.1 They compared markers in lesion psoriatic skin vs. non-lesion and normal healthy skin. The group discovered that psoriatic lesions expressed the highest number of proteins (145) in comparison to non-lesion (74) and normal skin (11). Two dominant proteins, glutathione S transferase (GSTP1) and peroxiredoxin 2 (PRDX 2) were significantly upregulated in psoriatic skin pointing towards a compensation mechanism for reducing oxidative stress in the chronic inflammation state. The second study published by Johansen et al. points towards limitations of gene expression studies that are overcome by proteomic analysis.2 When comparing lesion vs. non-lesion psoriatic skin mRNA levels of TNF-α appear similar. However, proteomic analysis of post-translational modifications to TNF-α varies
Structure of peroxiredoxin 2. Courtesy of www.Wikipedia.org.
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Courtesy of Rihe Liu, Ph.D., The University of North Carolina at Chapel Hill, https://pharmacy.unc.edu.
significantly. Moreover, utilizing proteomic techniques the group was able to draw the pharmacological cascade that involves other related proteins and identify TNF-α as a target for disease mitigation. They discovered that increased levels of MAPK-2 (mitogen-activated protein kinase-2) together with increased MK2 kinase (a mitogen activated kinaseactivated protein) activity are found in lesions when compared to non-lesion psoriatic skin. The increased activation of MK2 is responsible for the elevated and post-transcriptionally regulated TNF-α. In fact it was discovered that in its inactive form, MK2 is located in the nucleus, and only upon activation by p38a and p38b MAPKs, it is translocated from the nucleus to the cytoplasm to generate effect.
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incomplete surveys. Normalization of background protein binding and robust negative controls are intrinsically challenging with compound immobilization methods. The advantage of the CCDP method is that solution phase compounds are not subject to orientation biases. Negative controls are robust. Furthermore, it can be applied towards any compound as it does not require substitution or tag modifications. As compound concentrations can be varied, some measure of relative binding affinities between compounds can be characterized. Finally, when sufficient protein quantity is available, protein compression is achievable, and may help minimize bias towards the high abundance protein content and uncover low abundance interactions that otherwise would have been hidden. Coupled to LC-MS/MS, gene sequence annotation of these sub-proteomes (the “interactomes”) can identify prospective biomarker proteins that interact with the challenging compound. Upon identifications established here, with guidance towards the functional pathways modulated by the drug-protein
Exploring opportunities For skin research, proteomics can generate protein profiles for a variety of end points that include treatment and exposure regimens; i.e., chemicals and finished formulations, comparison between young and elderly, healthy and diseased skin, different body sites, ethnicities, genders, and the like. Functional proteomics differs from conventional proteomics as it relies in part on the functional or structural features of intact, nondenatured proteins. Chemical and affinity based proteomic profiles can be considered subsets of functional proteomics. One such proprietary method, called compound-centric displacement proteomics (CCDP), enriches for the complement interactomes (the subset of interaction proteins) of a small molecule or active compound. In contrast to common methods, compound-centric displacement proteomics (CCDP) efficiently profiles small molecule compounds as displacement agents from surface architectures that support weak affinities of complex proteomes. Previous chemical proteomic methods relied on first immobilizing the compound on the surface. Such methods can distort the compound’s orientation, generating misleading results and V V O O L L U U M M E E
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Courtesy of W. Andy Tao, Ph.D., Purdue University, West Lafayette, IN, www.chem.purdue.edu.
interactions, a mechanistic interpretation can be made to describe the phenotypic changes associated with the cells. In recent years there has been great progress in the establishment and understanding of in vitro and ex vivo models to study skin. Still, no method can replace a well-designed clinical study, but such studies are costly and time consuming. The prediction of clinical impact based on in vitro screening affords tremendous cost savings, bringing better actives to the right applications. While proteomic assessment is fundamentally another in vitro/ex vivo method, it bypasses some of the bias associated with direct markers analysis or gene expression and therefore may provide a closer correlation to in vivo scenarios. (Continued on page 6)
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References 1. J. Ryv, S. Goo Park, B. Chol Park, M. Choe, K.S. Lee, and J.W. Cho, “Proteomic analysis of psoriatic tissue for identification of differentially expressed proteins: upregulation of GSTP1, SFN and PRDX2 in psoriatic skin.” Int. J. Mol. Med., 28(5) 785-792 (2011). 2. C. Johansen, A. Toftegard Funding, K. Ofkjar, K. Kragballe, U.B. Jensen, M. Madsen, L. Binderup, T. SkakNielsen, M. Scheel Fjording, L. Iversen, “Protein expression of TNF-α in psoriatic skin is regulated at a post transcriptional level by MAPK activated protein kinase 2, The J. Immunol.,176, 1431-1438 (2006).
About the Authors:
Nava Dayan, Ph.D., Dr. Nava Dayan L.L.C. Dr. Nava Dayan is an independent consultant with 24 years of experience in variety of aspects of skin care; offering a wide range of services for the pharmaceutical, cosmetic, and personal care industries as well as research entities, regulatory agencies, and academic institutions. Her primary service focus is on innovation, bridging technology to industry, identifying paths in product development, efficacy claims, safety assessment, skin absorption, increased efficacy, and strategies to attenuate adverse effects. Nava’s area of expertise spans skin aging, skin inflammatory disorders, delivery systems for enlargement of therapeutic index, natural ingredients and formulations, skin’s innate immunity and barrier integrity, biochemical paths analysis, and skin research of toxicological endpoints and their assessment. Dr. Dayan holds a Bachelor’s degree in Pharmaceutics, Master’s degree in Pharmaceutics and Pharmacology, and a Ph.D. in Pharmaceutics. All degrees were obtained from the Hebrew University in Jerusalem.
Matthew Kuruc, ProFACT Proteomics
Innovation for Hair & Skin
Matthew Kuruc is a serial entrepreneur, starting as a co-founder of Affinity Technology Inc., where he was President from 1990-1996. After it was acquired by LigoTech, Inc., he held an executive business development role until becoming co-founder of ProFACT Proteomics in 2004. Prior to that, he held various marketing and sales positions at Amicon Division of W.R.Grace & Co. (now Millipore), and industrial separations equipment suppliers. He holds a B.S. in Chemical Engineering from Rutgers University.
Accessibility to testing croda.com/na/pc
The future is accessible. Proteomics requires a combination of expertise and knowledge. For this, Dr. Nava Dayan L.L.C and ProFACT Proteomics have formed a collaborative initiative combining skin science and research with wet-end experimental observation, and bioinformatic interpretation. ProFACT brings an understanding of techniques in extraction, separation, isolation, and analysis of proteins in a variety of customized approaches. Dr. Dayan has industrial experience and analysis skills in skin biochemistry that are utilized both in study design as well as in data interpretation and claims substantiation.
Upcoming 2013 NYSCC Events Calendar • For updated NYSCC information, visit us on the web at: www.nyscc.org • For National SCC information: www.scconline.org November 13 Cosmetic Technology Transfer Conference, Renaissance Woodbridge Hotel, Iselin, NJ December 12-13 2013 Annual Scientific Meeting and Technology Showcase, New York, NY
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Save the Date June 5, 2014 Poster Competition: Call for Abstracts New York Academy of Sciences World Trade Center, Building 7 • New York, NY The New York Chapter of the Society of Cosmetic Chemists is proud to announce the 2014 NYSCC Antioxidant Symposium, which will feature key academic and industrial researchers in the field of antioxidants and the skin. The conference will be held on the top floor of the newly constructed Building 7 of the World Trade Center, home to the New York Academy of Sciences. There will be a concurrent poster session in which entries will be eligible for the poster competition and will be judged on originality and innovation relevant to methodologies and the use of antioxidants in skin care.
Poster Prizes: 1st place: $1,500 2nd place: $1,000 3rd place $500
Please send poster abstract submissions by January 15, 2014 to Jenna Jelinski at JJelinski@morretec.com.
Conference attendees will receive a complimentary book:
Antioxidants and the Skin
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Hair & Scalp Biology Workshop November 11 This one day intensive workshop on hair and scalp biology, taught by leading hair biologist, Dr. Gillian Westgate, is intended to organize and advance hair and scalp biology as an integral component of hair care product development. ____________________________________________________________________________________________
Variations of Hair & Skin November 12-13 This focused international conference will provide a unique platform to discuss variations of both hair and skin due to ethnicity, age, and health, and approaches to design and market innovative products targeted to treat these effects. This year's conference will have a special focus on scalp, underarm, and baby care. __________________________________________________________________________________________________________________________________
Measuring Skin & Product Applications November 14-15 Rossow USA Inc. Distributors of Smart Cosmetic Ingredients
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Ingredients ffor or Quality Ingredients ŽƐŵĞƟĐƐ ŽƐŵĞƟĐƐ ĞƌŵŽͲĐŽƐŵĞƟĐƐ ĞƌŵŽͲĐŽƐŵĞƟĐƐ
Dr. David Moore and Dr. Nik Kollias moderate this two-day hands-on course focused on measurement science and linking these measurements to skin physiology. Included in this workshop are technical discussions on the physiology of skin, anatomy of skin, molecular biology, irritation, inflammation, pigmentation, transport barriers, biophysics, and bio-responses. __________________________________________________________________________________________________________________________________
For more information on all three events contact Eleanor Lehman at events@triprinceton.org, or (609) 430-4820; or visit their website at www.triprinceton.org/education.
Phone : 1-855-7ROSSOW Email : contact@rossow-usa.com W eb : www .rossow.fr Web www.rossow.fr
PParleam® arleam® Aloe Vera Vera Wilbride® Lipidur Lipidure® e® ^^Ͳ&ĂĐĞΠ Ͳ&ĂĐĞΠ
SCC Continuing Education November 14 November 14-15
Skin Diseases and Dermatopharmacology Regulatory Update
December 11
Molecular Biology, Gene Expression for the Cosmetic Chemist
December 11
Low-energy Emulsification For more information, visit www.scconline.org.
Make note of it…Cosmetiscope Send news of interest, guest editorials, and comments to: Roger McMullen, Editor E-mail: roger_mcmullen@fdu.edu 8 8
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Don’t Worry, Be Happy You’re Dead!
…Donald Koelmel
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nly God and Jesus can raise the dead. Few mortals are so blessedly enabled. Hence, you working stiffs are stuck. But membership in this club has its privileges. Let’s review a few.
1. No more thinking. Phew! Talk about a load off. What should I think and do today? Let me get out the corporate manifesto. Here it is. Sit through endless meetings while nodding yes constantly. Plus, find at least two cures for cancer by five o’clock. So leave that big, heavy brain of yours at home tomorrow. And now you can wear your kid’s baseball cap. 2. You are now as cool as a hippie. How so? In a sense, you too live an alternative lifestyle. Your permanently altered state of being qualifies as such. So keep on truckin’ Daddy-O! 3. Reincarnation will upgrade your status. Oh, you’ll still be a Walking Dead, but look below you. All of your former tormentors now report to you. Thank you, laws of Kharma! 4. Best for last—no more taxes! After you die, the State and Federal government seriously pick your pockets one last time. So what are all these ongoing deductions from your paychecks? You’re dead! You already paid! This outrage must stop. Call and write your local Carlos (or Carlota) Danger and tell them to re-write the tax code. Remind them that, to borrow from the NRA slogan, “I am the Living Dead. And I vote!”
A t t e n t i o n
The soul and science of beauty. www.evonik.com/personal-care
M e m b e r s
Unemployed and Emeritus members may continue to attend monthly meetings free of charge. Please contact the registration booth upon arrival. Unemployed members may also continue their membership free of charge by submitting the renewal form with unemployment details. Please remember that the SCC Employment Service is here to assist you. Contact: Guojin Lu • E-Mail: glu@ashland.com
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Employment Opportunities Send employment ads to…Guojin Lu (glu@ashland.com) and Roger McMullen (roger_mcmullen@fdu.edu). Employment listings published in the Cosmetiscope are abridged due to space limitations. 10-10-2013 ■ DIRECTOR OF QUALITY Intercos America, Global Manufacturer of Cosmetics located in Rockland County, New York is seeking Director of Quality. In this role, incumbent will be responsible for the Quality Management and Quality Assurance Activities. Essential duties: • Maintain and improve the quality system and documentation. • Assure that company meets all regulations including GMP and GLP in accordance with FDA regulations and guidelines. • Responsible for all staffing, salary, personnel reviews, and development and succession planning. • Manage client complaint and non-compliance investigation and corrective actions. • Manage audits from authorities, customers, and certification organizations. • Assure that product in-process quality control meets all approved company and client requirements. • Responsible for budget planning, tracking, and management. • Manage all testing requirements, including validations and reporting (COA). • Manage supplier and contract manufacturing approval program. Qualifications: • B.S. degree in Applied Sciences or Engineering (Biology, Chemistry, Physics, or comparable). • Experienced in quality or product development. Five years management experience. • Knowledge of quality systems. Skills: • Critical thinker; problem solver. • Good computer, interpersonal, and communication skills. • Leader, team player, and self-starter. Please send résumé and cover letter with salary requirements to: hrresumes.only@gmail.com. _____________________________________________________________ 10-08-2013 ■ ASSOCIATE CHEMIST, SKIN CARE PRODUCT DEVELOPMENT NeoStrata Company, Inc. in Princeton, NJ is seeking an Associate Chemist for Skin Care Product Development. This Position will be responsible for assisting in the development of new and innovative skin care and color cosmetic formulations, as well as reformulation of existing products as required. Essential duties: • Formulate a wide range of skin care and color cosmetic formulations. • Conduct raw material testing for formulations and fill products for product stability testing purposes. • Understand the basic principles of good experimental design, data analysis, and interpretation. • Learn to master use of laboratory equipment and processes required to make formulation batches. • Perform measurements on ingredients and formulas. • Tabulate data and review and edit manufacturing procedures. • Order raw materials and lab supplies, and wash glassware. • Help maintain database content including inputting formulas and raw material documentation. Qualifications: • B.S. degree in Chemistry or other scientific discipline.
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• 0–2 years of industrial experience in chemistry, ideally formulation development experience; knowledge of skin care product development processes is desired as well as emulsion technology and chemistry. • Familiarity with standard laboratory practices, concepts, and procedures. • Highly computer literate; experience with web-based databases/ programs, Microsoft Suite. • Excellent verbal and written communication and organizational skills. Please send résumé to pkonish@neostrata.com _____________________________________________________________ 10-08-2013 ■ LAB/QA/QC TECHNICIAN (SPECTRACOLORS) This position is primarily responsible for performing laboratory tests to determine chemical and physical characteristics, or composition of solid and liquid materials for such purposes as quality control, process control, or product development by performing the following duties. Duties and responsibilities: • Sets up, adjusts, calibrates and operates laboratory equipment and instruments such as microscopes, centrifuge, agitators, viscometer, chemical balance scales, spectrophotometer, gas chromatograph, colorimeter, and other equipment. • Tests materials for presence and content of elements or substances such as hydrocarbons, manganese, natural grease, tungsten, sulfur, cyanide, ash, dust, or impurities. • Tests samples of manufactured products to verify conformity to specifications. • Records test results on standardized forms and writes test reports describing procedures used. • Records test data, applying statistical quality control procedures. • Prepares graphs or charts of data or enters data into computer for analysis. • Prepares chemical solutions according to standard formulas. Qualifications: • Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. • Ability to distinguish color shade. • Bachelor’s degree (B.S.) in Chemistry from a four-year college or university; or four to five years related experience and/or training; or equivalent combination of education and experience. If interested, send résumé to Alexis@SpectraColors.com. _____________________________________________________________ 09-16-2013 ■ SENIOR CHEMIST, SKIN CARE FORMULATION Englewood Lab, LLC, located in Englewood, NJ, is seeking a Senior Chemist with strong technical skills and a passion for product innovation to join the R&D Skin Care Formulation Team. Responsibilities: • Formulate and facilitate development of innovative skin care products, line extensions, and product improvements. • Identify new/improved formulation technologies and implement them to meet project needs. • Interact with customers and provide technical support via oral, presentation, and written venues. • Proactively scan and research new concepts, materials, technical opportunities, and partnerships. • Interfaces with all departments throughout the company and interacts with material suppliers. • Monitor product stability for your own formulas.
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• Effectively manage projects and provide weekly status reports. Experience/Education/Skills: • Minimum of 10 years of experience in developing cosmetic skin care formulations. • Strong understanding of formulations and scale-up. • Bachelor’s degree in a scientific discipline; Master’s degree is a plus. Please send résumé to: englewoodlabHR@gmail.com. _____________________________________________________________ 09-16-2013 ■ INSIDE SALES SEPPIC Inc., a leading global specialty ingredients supplier, has an opportunity for an Inside Sales Representative that will cover the United States. This position will be based out of our Fairfield, New Jersey office. Responsibilities include: • Promote ingredients to existing accounts and cold calling potential accounts. • Develop and maintain customer relationships with R&D and purchasing. • Provide all aspects of technical support to new and existing customers. • Develop territory sales strategies to maximize growth opportunities. • Generate monthly sales reports, enter all call reports in CRM, and contribute to budgeting and forecasting. • Coordinate and participate in local and national industry shows. Territory: United States Requirements: • B.S. in Chemistry, Biology, or related field. • Two to four years of personal care industry related sales experience, or related personal care technical experience. • The successful candidate will be dynamic, motivated, and independent with the ability to self-manage their time as well as the ability to be an international team player. • Applicant must have the ability to juggle several priorities simultaneously with excellent communication and negotiation skills. • Understanding of French is a plus. Position provides competitive wages/bonus and benefits package, backing of our NJ Sales Office, and support and training from our Delaware Customer Technical Service Center laboratory. Please e-mail your résumé to: Peter Frantz, Personal Care Sales Manager North America at peter.frantz@airliquide.com. _____________________________________________________________ 09-06-2013 ■ APPLIED RESEARCH CHEMIST Symrise, the world’s 4th largest manufacturer of flavors, fragrances and aroma ingredients, is seeking a hands-on Chemist to develop new and existing fragrance technologies for consumer products and prepare formulated samples for consumer testing. Responsibilities: • Research raw material performance, encapsulation, and odor control in finished products. • Conduct sensory testing of raw materials and fragrances to support product development. • Interface with sales, marketing, and development to support technology concepts. • Create and conduct client presentations and develop new technological approaches to more effectively deliver fragrances. Qualifications: • Bachelor’s degree in Physical Organic Chemistry, Analytical Chemistry, Surface Science, Chemical Engineering, or related field. • 5–10+ years’ chemical or fragrance lab experience. • Ability to effectively conduct sensory testing to develop fragrance technologies.
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• Strong communication and PC skills including proficiency with MS Word, Excel & PowerPoint. • Ability to manage projects under minimal supervision as well as alongside other team members. • Knowledge of encapsulation techniques, malodors, fragrances, flavors, GC HPLC, headspace analysis, household products, personal care products, care products, or surfactants is desirable. Apply Link: http://www.pcrecruiter.net/pcrbin/reg5.aspx?i1=WEBGUEST&i2=209400 643888216&i3=DETAIL&i4=209400643888216&i5=&i6=&i7=&i8=9% 2f6%2f2013%202:17:47%20PM&hash=1296522574&i10=&pcrid=8xu%2fNSfMW4OP3YEd7RQxlczrrJjzTWxNplBzhptb%2bWvoFrt7 OkwW2q0MTRxqFTjBH1RquO9c%2b7ht%0d%0aB%2fEBaB0mJuLka3 hVZ6GpGH2%2b1g%3d%3d _____________________________________________________________ 08-30-2013 ■ SALES ACCOUNT MANAGER TRI-K Industries, Inc., a leading supplier and manufacturer of specialty raw materials to the global personal care and cosmetics industry, is expanding its domestic and international sales teams and seeks experienced and qualified candidates for the role of Sales Account Manager for those regions. Responsibilities: • To generate sales by expanding and maintaining relationships with existing clients and prospecting new accounts within the territory. • Develop and implement account specific sales strategies to meet and exceed budget. • Routinely call on Key Accounts to understand their needs and requirements and develop account relationships. • Present and promote new and alternative ingredients and technology. • Prepare forecasts and reports, and utilize the CRM database. • Participate in trade shows, sales conferences, and sales meetings. Qualifications: • Bachelor’s Degree in Chemistry or related field. • Minimum 5 years of sales experience in the Personal Care industry. • Considerable travel required with overnight stays. • Excellent follow-up, communication, and computer skills. Contact Information: Forward résumé to: PeopleEnergy@tri-k.com. Indicate job title, Sales Account Manager, in the subject line. Only candidates under consideration will be contacted. _____________________________________________________________ 08-27-2013 ■ SENIOR CHEMIST Kolmar Laboratories, Inc., located in Port Jervis, NY, is seeking a Senior Chemist to work in a personal care capacity. Job Function: • Direct and perform diversified product development as well as product stability/compatibility testing. • Plan and coordinate product development assignments within the lab. • Supervise workload for at least two technicians/technologists. Responsibilities: • Review customer specifications and requirements; meet with customers to properly implement product profiles. • Develop new formulations to customer and/or marketing specifications. • Identify and interpret variations in product, equipment, and procedures which may affect final results. • Maintain working knowledge of all stages of finished goods production and all pertinent documentation. • Code new raw materials and make decisions as to raw material substitutions.
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• Maintain current knowledge of new raw materials and technology via meetings with suppliers and seminars. • Assist, mentor, and guide junior laboratory personnel on formulation development and research of projects as needed. Qualifications: • Mastery of daily product development operations. • Bachelor’s degree in Chemistry or related science. • Seven years of formulation experience in emulsion technology, preferably in color cosmetics. For consideration, please submit résumé to: cschaefer@kolmar.com. _______________________________________________
• Analyze formulations and mechanics of interaction between pigments and various other constituents of cosmetic and personal care products. • Provide Sales and Marketing support through appropriate application samples. • Provide technical support for our customer base. • Translate customer feedback into new and/or improved product formulations. • Knowledge of claim substantiation support. Apply link: http://jobs.basf.us/job/Tarrytown-Cosmetic-Chemist-lTarrytown%2C-NY-Job-NY-10591/2800703/ _______________________________________________
08-22- 2013 ■ APPLICATION LAB MANAGER/DIRECTOR Kobo Products, Inc., a raw material cosmetic/ personal care manufacturer and distributor, is seeking an experienced Manager/Director for the Applications Lab. The preferred candidate should have strong communication skills, and at least ten years formulation experience in color cosmetics. Responsibilities: • Develop new formulas for color, sunscreens, and skin care products. • Work with customers and suppliers. • Train and develop laboratory technicians. • Work with Kobo Sales, Marketing, and R&D for new product development. • Some travel is required to attend trade shows or visit customers. Requirements: • B.S. degree in Chemistry is preferred. • Microsoft Office experience required (Word, Excel, PowerPoint, and Outlook). Please send résumé and include salary requirements to: stortorella@koboproductsinc.com. Please reference “Applications Lab Manager/Director” in the subject field. _______________________________________________
08-19-2013 ■ CHEMICAL SALES – NORTHEAST PERSONAL CARE AND HOUSEHOLD Thor Specialties, Inc. has an opening for a Technical Sales Representative – Personal Care and Household for the Northeast region. This position will be based in the Newark, New Jersey area. The position involves developmental selling, managing commercial relationships, and some technical service to the personal care and household markets. Thor Specialties is a wholly owned company of the Thor Group, a specialty chemical company with approximate sales of $300 million. Thor Specialties is a supplier of biocides and other specialty chemicals for a variety of industries including paints and coatings, polymers, adhesives and sealants, wood treatment, water treatment, home care, and personal care. Requirements: • Minimum of three years of chemical or pharmaceutical sales experience. • Bachelor’s degree in Chemistry, Chemical Engineering, Biology, or Microbiology. • Experience in the personal care/household markets is a plus. • Excellent verbal and written communication skills. • Computer proficiency with typical business software. E-mail résumé and cover letter with salary requirements to: jobapps@thorsp.com. _______________________________________________
08-20-2013 ■ COSMETIC CHEMIST I BASF has an opening for a Cosmetic Chemist to join our Personal Care team in Tarrytown, NY reporting directly to the Group Leader, Global Development and Technical Service Effect Pigments. The ideal candidate should be self-motivated, driven, and innovative, with an interest in cosmetic formulation, testing analysis, research, and documentation. Major responsibilities: • Formulation of all types of cosmetic products with emphasis in color cosmetics. • Develop an understanding of Effect Pigments. • Monitor stability and compatibility progress of formulations and/or new ingredients. • Perform laboratory experiments relating to color cosmetic products. • Demonstrate fundamental understanding of general chemistry concerning cosmetic raw ingredients. • Use of analytical and experimental data to analyze cause/effect relationships between various components of cosmetic and personal care materials.
08-16-2013 ■ COSMETIC INGREDIENT SALES – SOUTHEAST U.S. Independent Chemical Corporation, one of America’s Top 100 Chemical distributors, seeks an experienced sales representative for our Southeastern U.S. territory. This position would be responsible for the geography of South Jersey through Ohio extending down to Florida. The successful candidate will be responsible for selling our lines of specialty actives and excipients, cellulose scrubs, exotic oils, esters, and surfactants. The position will be field based and the candidate must live within the territory. Candidate must have 2+ years of sales and formulation experience. Position includes salary, car allowance, health, and performance incentive. Visit www.Independentchemical.com for more information on our product lines, and send résumé and salary requirements to: Jonathan@independentchemical.com. N N O O V V E E M M B B E E R R
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