Type 1 Diabetes at NYSCF

TYPE 1 DIABETES

1.25 Million

Less than

1/3

Americans

have type 1 diabetes, which is expected to increase to

5

of people with type 1 diabetes

consistently achieve target blood glucose control levels

Million by 2050

Type 1 diabetes costs the United States approximately

14 Billion

$

each year

For nearly 100 years, we have used insulin therapy to treat the symptoms of type 1 diabetes.

Maintaining healthy blood sugar levels requires intensive monitoring and management.

Stem cells are our greatest hope for a cure Curing type 1 diabetes was an inspiration for founding NYSCF.

At NYSCF, we are using stem cells to develop a therapy

that replaces the insulin-producing cells that are destroyed by the immune system in type 1 diabetes.

1

st

NYSCF funded the

human stem cell model of diabetes

Our diabetes research was named a

NYSCF has dedicated almost

#1 Medical Breakthrough

to type 1 diabetes research

TIME Magazine

$15 Million

STEM CELLS ARE THE KEY TO CURING DIABETES

STUDYING A HUMAN DISEASE IN HUMAN CELLS Using stem cells, we can generate the actual human pancreatic cells destroyed in type 1 diabetes — without invasive surgery. Traditionally, mice are used to study diabetes, but while we have cured mice of diabetes numerous times, these therapies do not work in humans because our biology is different. Stem cells give us a living window into how pancreatic cells function, interact, and degenerate, just as they would in the human body.

FINDING EFFECTIVE DRUGS TO TREAT DIABETES We are creating human pancreas cells from a diverse population of patients with type 1 diabetes to enable drug testing. This accelerates drug discovery, by identifying drugs that are good candidates for clinical trials. We are integrating artificial intelligence into our research to better predict which drugs will work for which patients.

CURING DIABETES WITH CELL REPLACEMENT THERAPIES Replacing the dying beta cells in the pancreas with personalized, healthy ones is our golden opportunity for a type 1 diabetes cure. Using stem cells, we are creating pancreatic beta cells with the potential to integrate into a patient’s body and restore healthy pancreas function. To ensure these cells remain safe from the autoimmune attack, we are working to engineer them to be invisible to the immune system.

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