AArkstore enterprise Aarkstore - Frontier Pharma: Alzheimers Disease - Identifying and Commercializing First-in-Class Innovation Browse Full Report @ http://www.aarkstore.com/pharmaceuticals-healthcare/105777/frontier-pharmaalzheimers-disease-identifying-and-commercializing-first-in-class-innovation
Published: Nov 2014| No. Of Pages: 101 PDF: $ 6995 | Site Licence: $ 13990 | Enterprise Wide Licence: $ 20985
Frontier Pharma: Alzheimer’s Disease - Identifying and Commercializing First-in-Class Innovation Summary Large and Innovative Pipeline The active Alzheimer’s Disease (AD) pipeline is populated with 583 products, with a highly diverse range of molecular targets. GBI Research analysis revealed a high degree of innovation in this indication, with 46% of the pipeline being first-in-class products, acting on over 40 first-in-class molecular targets. In addition, the pipeline is characterized by the strong presence of therapies that target multiple components implicated in the amyloid cascade, several molecular targets of which are known to trigger familial AD. Given that the currently approved therapies for AD are limited to acetylcholinesterase inhibitors and glutamate receptor antagonists, the pipeline offers a broad range of treatment options that may possess disease-modifying properties. However, evaluation of the Preclinical and clinical evidence for their therapeutic potential reveals that the novelty of the molecular
AArkstore enterprise target is not sufficient to effectively reduce the rate of AD progression in human patients. Disease-Modifying Therapies Show Promise in Early-Stage Development Programs undergoing Preclinical development exhibit diverse disease-modifying mechanisms of action, and many represent strong alternatives to targets with a direct role in the amyloid and tau processes due to their roles in promoting neuronal survival and plasticity, a process critical to memory and cognition. Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) are considered promising targets in AD, primarily due to their potency in exhibiting significant neuroprotective effects in Preclinical studies. Members of the caspase-mediated apoptotic cascade also show therapeutic potential, as early investigations have revealed an ability to modulate molecular mechanisms underlying synaptic plasticity in animal models, which translates into amelioration of behavioral deficits. Thus, growing insights into disease-causing processes in AD are being translated into a growing population of innovative therapeutic targets, as reflected in the highly innovative pipeline. The merits of novel molecular targets depend largely on the body of Preclinical evidence underpinning their relevance to AD pathology. Many endpoints in Preclinical investigations focus on amelioration of amyloid burden and tau pathology, as well as cognitive performance in animal model systems. Based on these assessment criteria, it appears that programs targeting the amyloid cascade, tau pathology, and the promotion of neuronal survival and plasticity all demonstrate promising efficacy profiles. Other first-inclass targets that are less directly aligned to these three processes may not be able to confer disease-modifying properties and therefore lack clinical and commercial potential. Active Deals Landscape with Numerous Investment Opportunities The AD deals landscape has been highly active over the past eight years, with 83 licensing agreements and 103 co-development deals. Overall, non-first-in-class programs tend to have lower valuations than first-in-class programs across all stages of drug development, which highlights their commercial attractiveness, even in early-stage development. Although first-in-class programs are associated with greater risk, they have more potential to revolutionize or improve therapeutic options, meaning that identifying promising first-
AArkstore enterprise in-class compounds early in development offers the greatest potential commercial benefit to pharmaceutical companies. With 153 first-in-class products that are currently in development having not yet been involved in a licensing or co-development deal, there are numerous opportunities for inlicensing or co-development in this indication. Scope The report covers and includes - A brief introduction to AD, including symptoms, pathophysiology, and overview of pharmacotherapy and treatment algorithms - The changing molecular target landscape between market and pipeline and particular focal points of innovation in the pipeline - A comprehensive review of the pipeline for first-in-class therapies, analyzed on the basis of stage of development, molecule type and molecular target - Identification and assessment of first-in-class molecular targets with a particular focus on early-stage programs for which clinical utility has yet to be evaluated, as well as literature reviews of novel molecular targets - Assessment of the licensing and co-development deal landscape for AD therapies and benchmarking of deals involving first-in-class versus non-first-in-class-products Reasons to buy The report will assist business development and enable marketing executives to strategize their product launches, by allowing them to - Understand the focal shifts in molecular targets in the AD pipeline - Understand the distribution of pipeline programs by phase of development, molecule type and molecular target - Access a scientific and clinical analysis of first-in-class developmental programs for AD, benchmarked against non-first-in-class targets - Access a list of the first-in-class therapies potentially open to deal-making opportunities Browse complete Report on:
AArkstore enterprise http://www.aarkstore.com/pharmaceuticals-healthcare/105777/frontier-pharma-alzheimersdisease-identifying-and-commercializing-first-in-class-innovation
Table of Contents: 1.1 List of Tables 3 1.2 List of Figures 3 2 Executive Summary 4 3 The Case for Innovation 6 4 Clinical and Commercial Landscape 11 5 Assessment of Product Pipeline Innovation 21 6 Signaling Network, Genetics and Innovation Alignment 35 7 First-in-Class Target Evaluation 39 8 Deals and Strategic Consolidations 75 9 First-In-Class Molecules not Involved in Licensing or Co-development Deals 86 10 Appendix 89 List Of Tables Table 1: Mini-Mental State Exam, 2005 15 Table 2: Alzheimer’s Disease Assessment Scale, Cognitive Subscale, 1984 16 List Of Figures Figure 1: Innovation Trends in Product Approvals, 1987–2012 6 Figure 2: Sales Performance of First-in-Class and Non-First-in-Class Product post Marketing Approval, 2006–2013 8 Figure 3: Sales Performance of Central Nervous System First-in-Class and Non-First-inClass Products post Marketing Approval, 2006–2013 8 Figure 4: Alzheimer’s Disease, Global, Developmental Pipeline 22 Figure 5: Alzheimer’s Disease, Global, Established and First-in-Class Pipeline 25 Figure 6: Alzheimer’s Disease, Global, Established Developmental Pipeline Part 1, 2014 27 Figure 7: Alzheimer’s Disease, Global, Established Developmental Pipeline Part 2, 2014 28 Figure 8: Alzheimer’s Disease, Global, Established Developmental Pipeline Part 3, 2014 29 Figure 9: Alzheimer’s Disease, Global, Established Developmental Pipeline Part 4, 2014 30 Figure 10: Alzheimer’s Disease, Global, First-in-Class Developmental Pipeline Part 1, 2014
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