AArkstore enterprise 25th November 2014
Aarkstore - hERG Screening Browse Full Report @ http://www.aarkstore.com/biotechnology/53593/herg-screening Published: Apr 2014 | No. Of Pages: 245 Pages PDF: $4590 | Global Licence: $9100
hERG Screening Market research report presents an in depth analysis of hERG Screening market. The study emphasizes on both technology and product segments of hERG Screening in biotechnology and pharmaceutical application areas. The report provides essential information including market data, segmentation, market size, key trends, M&A, product developments, industry forecasts, corporate intelligence, and other relevant information. The report lists more than 190 companies that are engaged in hERG Screening services and/or production of hERG screening tools/instruments. A global perspective is presented along with regional analysis covering North America, Europe, Asia-Pacific and Rest of World. Compilation of Worldwide Patents and Research related to hERG Screening is also provided. The hERG Screening market size is analyzed in US Dollars and includes 30 exclusive graphically illustrated exhibits.
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Table of Contents: 1. SCOPE AND METHODOLOGY
II. REPORT SYNOPSIS Introduction Ion Channels History Types of Ion Channels Voltage-Gated Ion Channel Ligand-Gated Ion Channel Normal Functioning of Heart
AArkstore enterprise QT Interval Short QT Syndrome Long QT Syndrome Types of LQTS Genetical LQTS Acquired LQTS Signs and Symptoms Drug Induced LQTS Causes Long QT Syndrome and Torsade de pointes Recording the Electrical Activity of Heart Beat Diagnosis of LQTS Treatment PQRST Wave Cell Lines HEK 293 Cell Lines CHO or Chinese Hamster Ovary Cells hERG and Drug Discovery hERG Screening - Global Market Analysis Exhibit 1. hERG Screening - Global Value Market Estimations & Predictions (2005 - 2020) in US$ Million (Graphical Representation Included) Exhibit 2. List of Major Global Companies
AArkstore enterprise III. MARKET DYNAMICS 1. Market Overview Global hERG Screening Market Exhibit 3. hERG Screening - Global Value Market Estimations & Predictions (2005 - 2020) in US$ Million by Geographic Region for North America, Europe, Asia-Pacific and Rest of World (Graphical Representation Included) Exhibit 4. hERG Screening - Global Value Market Shares (2010, 2015 & 2020) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World (Graphical Representation Included) The Impact of hERG North American hERG Screening Market Exhibit 5. hERG Screening - North American Value Market Estimations & Predictions (2005 2020) in US$ Million by Country for United States and Canada (Graphical Representation Included) Exhibit 6. hERG Screening - North American Value Market Shares (2010, 2015 & 2020) by Country for United States and Canada (Graphical Representation Included) United States hERG Screening Market Canadian hERG Screening Market Exhibit 7. List of Major North American hERG Screening Companies European hERG Screening Market Exhibit 8. hERG Screening - European Value Market Estimations & Predictions (2005 - 2020) in US$ Million by Country for United Kingdom, Germany, France, Switzerland, Russia and Rest of Europe (Graphical Representation Included)
AArkstore enterprise Exhibit 9. hERG Screening - European Value Market Shares (2010, 2015 & 2020) by Country for United Kingdom, Germany, France, Switzerland, Russia and Rest of Europe (Graphical Representation Included) UK hERG Screening Market German hERG Screening Market French HERG Screening Market Swiss hERG Screening Market Russian hERG Screening Market Exhibit 10. List of Major European hERG Screening Companies Asia-Pacific hERG Screening Market Exhibit 11. hERG Screening - Asia-Pacific Value Market Estimations & Predictions (2005 - 2020) in US$ Million by Country for Australia, China, India, Japan, South Korea and Rest of Asia-Pacific (Graphical Representation Included) Exhibit 12. hERG Screening - Asia-Pacific Value Market Shares (2010, 2015 & 2020) by Country for Australia, China, India, Japan, South Korea and Rest of Asia-Pacific (Graphical Representation Included) Australian hERG Screening Market Chinese hERG Screening Market Indian hERG Screening Market Japanese hERG Screening Market South Korean hERG Screening Market Exhibit 13. List of Major Asia-Pacific hERG Screening Companies Rest of World hERG Screening Market
AArkstore enterprise Exhibit 14. hERG Screening - Rest of World Value Market Estimations & Predictions (2005 - 2020) in US$ Million by Israel, South Africa, Brazil and Other Countries (Graphical Representation Included) Exhibit 15. hERG Screening - Rest of World Value Market Share (2010, 2015 & 2020) by Israel, South Africa, Brazil and Other Countries (Graphical Representation Included) Israeli hERG Screening Market South Africa hERG Screening Market Brazilian hERG Screening Market 2. Company Profiles - Major Players in hERG Screening Market Abcam PLC (UK) Abnova Corporation (Taiwan) Aurora Biomed, Inc. (Canada) AVIVA BioSciences Corporation (USA) B’SYS GmbH (Switzerland) Cellular Dynamics International, Inc. (USA) Cerep SA (France) ChanTest Corporation (USA) Charles River Laboratories International, Inc. (USA) More… 3. Major Activities in hERG Screening Market ChanTest Commences a Project, Funded by US FDA’s Center for Tobacco Products (CTP) Eurofins Panlabs Signs an Agreement with GE to Reinforce Drug Discovery Services
AArkstore enterprise Molecular Devices to Supply Fluxions IonFlux Automated Electrophysiology Systems and Associated Products Globally ChanTest Releases the CardioChannelGram™ and SaVety Assessment Aptuit Provides Electrophysiological Technology Platforms More… 4. Technology Comparison Patch Clamp Technology Exhibit 16. Patch Clamp Technology - Estimated Market Value by Company in US$ Million for 2011 (Graphical Representation Included) Exhibit 17. Patch Clamp Technology - Estimated Value Market Shares by Company for 2011 (Graphical Representation Included) hERG Screening Assays Exhibit 18. hERG Screening Assays - Estimated Market Value by Company in US$ Million for 2011 (Graphical Representation Included) Exhibit 19. hERG Screening Assays - Estimated Market Shares by Company for 2011 (Graphical Representation Included) hERG Screening Antibodies & Cell Lines Exhibit 20. hERG Screening Antibodies and Cell Lines - Estimated Market Value by Company in US$ Million for 2011 (Graphical Representation Included) Exhibit 21. hERG Screening Antibodies and Cell Lines - Estimated Market Shares by Company for 2011 (Graphical Representation Included) 5. hERG Screening - Market Outlook
IV. PRODUCT/TECHNOLOGY RESEARCH
AArkstore enterprise Introduction Channelopathies Ion Channel Safety Pharmacology Ion Channels as Pharmaceutical Targets What makes ion channels attractive targets for drug development? Patch-Clamp: The Gold Standard Ion Channels Basic Features of Ion Channel Biological Role Diseases Related to Ion Channels Exhibit 22. Diseases Involving Ion Channel Function Ion Channel Genes of the Human Genome Technologies for Ion Channel Characterization Towards Ion Channel Drug Discovery and Development Physiological Significance of Ion Channels Flux Assays in Ion Channel Screening Types of Ion Channels Voltage-Gated Ion Channel Structure Exhibit 23. List of Known Human Voltage-Gated Potassium Channel Alpha Subunits Exhibit 24. List of Voltage-Gated Potassium Channel Beta Subunits Mechanism
AArkstore enterprise hERG Potassium Channel Activators and Blockers hERG Channel Gating hERG Channel Structure Mechanisms of Action of Facilitators and Activators of hERG Current Type 1 Activators Type 2 Activators Ligand-Gated Ion Channel Introduction Regulation Clinical Relevance hERG Role of hERG Blockers in Cardiac Disorders Characteristics and Clinical Applications of Cardiac hERG/I (Kr) Potassium Channel Biophysical Properties and Molecular Determinants of Ziprasidone and its Role in Block Opening hERG Cell Lines HEK 293 Cell Lines History Application of HEK 293 Cells CHO or Chinese Hamster Ovary Cells hERG T-REx™ CHO Cells Role of Potassium, Magnesium and Calcium in Normal Functioning of Heart
AArkstore enterprise Magnesium Calcium Potassium Membrane Potential Improper Membrane Potential Description Task in Human Well Being Common Abnormalities and Ailments Atrial Arrhythmias Ventricular Arrhythmias: Arrhythmias Arising Because of Abnormalities in the AV node, Purkinje fibers, or Bundle of His Functioning of Heart Cardiac Phase Electrocardiogram (EKG or ECG) History QRS Complex T Wave Abnormality in Potassium Ion Channel Torsades de Pointes: a Cardiac Arrhythmia Characteristics of TdP Causes of TdP Risk factors for TdP
AArkstore enterprise Treatment QT Interval Short QT Syndrome Long QT Syndrome LQTS - The Causes LQTS - Risks LQTS - Signs and Symptoms Screening and Diagnostic Procedures Complications LQTS - Treatment Medical Devices and Surgical Procedures Clinical Trials Prevention Self-Care Coping Skills Lifestyle Changes LQTS - The Types Inherited Long QT Syndrome Exhibit 25. Drugs to be Avoided by Congenital QT Patients Exhibit 26. Drugs (Withdrawn from Market) (Avoided by Congenital QT Patients) Genetic Basis of LQTS LQTS Associated Syndromes
AArkstore enterprise Precautions Acquired Long QT syndrome Exhibit 27. Drugs which Block the hERG Channel Co-Factors of Drug Induced LQTS Symptoms for identification of drug induced LQTS High Probability of Drug Induced LQTS Symptoms: Suspected Cases of Drug Induced LQTS Symptoms: Unlikely Case of Drug Induced LQTS Symptoms: 1. Patch Clamp Technique Methodology Technique Configurations On-Cell Inside Out Whole-Cell Outside Out Perforated whole-Cell The Patch Clamp Technique Application QPatch 16 QPatch HT
AArkstore enterprise Q Patch Applications QPATCH HT: Effective Application in Ion Channel Drug Discovery Screening Station Plates The Q Plate Technique Q Plate Prospects Cell Preparation Unit Liquid Handling System Touch Screen Data Acquisition Q Patch Software 2. hERG Screening in Drug Discovery Action from Drug Approving Authorities Exhibit 28. Drugs (Discontinued in the Market) which Block the hERG Channel In silico Modeling in hERG Channel Blockers hERG Channel Archetypes and Pharmacophores Testing In Silico for hERG K+ Channel Blockers In Silico Categorization of hERG Channel Blockers: a Skill-Based Strategy hERG Screening - Drugs Banned Exhibit 29. List of Banned Drugs for Inducing LQTS hERG and Obesity 3. Product Trends
AArkstore enterprise The GLP hERG Channel Assay Benefits Attributed to the Use of CDI Services ICR 8000 - The latest Entrant in the Ion Channel Technology There are vast applications of ICR 8000: Applications of ICR 8000 Features and Parameters of ICR 8000 Uses: ICR 12000 ICR 12000 - An advanced version of Ion Channel Technology considered ideal for hERG channel assays Features and Parameters of ICR 12000 Rubidium Flux Assay IonWorks® HT in hERG Channel Screening Measurement of hERG Channel Currents Using IonWorks HT System Sophion’s Q Patch: QPatch 16 QPatch HT Cell Lines in hERG Screening Exhibit 30. List of hERG Screening Products/Technologies/Services by Company 4. Research Briefs Sequence and Structure Specific Elements of hERG mRNA Regulate Channel Synthesis and Trafficking Efficacy Ketamine Blocks hERG related Gene Potassium Channel
AArkstore enterprise Controlling the hERG Channel by Rab4 by neural Precursor Cell-expressed developmentally down regulated Protein (4-2 (Nedd 4-2) Do hERG Channel Inhibitors also Induce Phospholipidosis? Cataloging Molecules for their hERG Liability Restoration of hERG Channels in Micro Fabricated Silicon Chips More‌ V. Corporate Directory VI. Patents Information Related reports:
Stem Cells - Types, Technologies & Therapeutics Veterinary Vaccines Biomarkers Metabolomics RNAi Apoptosis ADME/Tox Technologies High Throughput Screening Chiral Chemicals Biotechnology Market Research Reports
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