201409 provaxs brochure v6

PROVAXS NETWORK In vitro and in vivo models and services for the development and validation of innovative therapeutics and vaccines.

INNOVATION THROUGH PARTNERSHIP, PROVAXS THE NETWORK Dendessum estiandae et rem eatem volupta sim quaspelibus andit ad ut re mo te volupta doluptur? Magnisi conseribus des molecea volut pliqui dolorum autatusanti re ped que niam, sed ene rercimet, sa cullaborum dioremporum aceatem et laccusdae asperumquia voluptat quas doluptatur? Os autempos doluptatatur simagnis molore il es aut et il milit, est eum quis maximol uptus. At plibus dionseque volorrorem. Agnatur?

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THERAPEUTICS

SERVICES

VACCINES

DIAGNOSTICS

EXPERTISE

PROVAXS SERVICES FROM SERVICE TO SCIENCE AND INNOVATION

PROVAXS SERVICES is a unique platform at Ghent University that offers high quality animal models and related services for your research and development projects. Our models and services can be either used for veterinary studies in the target animal or for nonclinical studies for human medicines.

The added value we bring to your project is based on several assets: • A broad portfolio of solid and well validated animal models in different species • Services are provided by a dedicated and highly qualified team and in line with industrial standards • Science at your service -- We offer a selection of animal models that are all based on the strong expertise of the scientists and researchers of Ghent University who developed them -- UGent scientists provide academic back up to assist in the finetuning of the protocol, the interpretation of the results and the writing of an expert report • High flexibility to adapt the existing models to the needs of the client • Performance of animal models can be combined with other activities like diagnostic services, in vitro models and field trials to support vaccine and drug testing

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NOT A COLD START BUT A STEP AHEAD

At PROVAXS SERVICES academic expertise and industrial product development thus touch each other by use of the in vitro and in vivo models that we offer. The strong link with Ghent University can lead to more intensive and fruitful collaborations resulting in new innovations that can improve animal health.

Since many years our models and services have proven their value for both fundamental research and for testing of new or marketed products. Today we offer: • animal facilities for a wide range of animal species (swine, cattle, poultry, goat, sheep, horse, dog, cat, rabbit, ferret, guinea pig and mice) • studies that comply with currently applicable scientific, legal, regulatory, and ethical requirements and guidelines • pharmacokinetic, bio-availability, residue and safety studies and bio-analysis with respect to the OECD and the EU principles of Good Laboratory Practice Increased awareness of biosafety and ethics motivated us to build new and modern facilities by the Q1 of 2015. This infrastructure will offer 9 animal units (670m2) at biosafety level (BSL)2 and 3 animal units (350m2) at BSL3, all capable of housing a range of different animal species and, as such, allowing maximum flexibility. The facility will meet the highest standards in view of biosafety (including sophisticated air-handling units, effluent decontamination and tissue digestion) and ethics (Directive 2010/63/EU).

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OUR SERVICES Can be of interest for different industrial sectors

MODELS

SEGMENT

OTHER

FEED ADDITIVES

VETERINARY PHARMA

(B) E. COLI ETEC

(P) COOPERIA ONCOPHORA

(B) E. COLI VTEC

(P) OSTERTAGIA OSTERTAGI

(B) SALMONELLA

(B) MYCOPLASMA (B) SALMONELLA

(V) PRRSV

(B) CLOSTRIDIUM PEFRF.

(B) E. COLI VTEC

(F) MYCOTOXINE

(B) E. COLI ETEC

(O) GLP (O) PHARMACOKINETICS...

(O) PHARMACOKINETICS...

are tailor made and can combine different aspects of our expertise according to your needs

PARASITOLOGICAL TECHIQUES

FIELD STUDIES

• Coprology-faecal egg counts, larval differentiation • Pasture larval counts • Serology, milk-antibodies, serum pepsinogen • ICH, RT-PCR, cytokines, micro-array • Nepcropsy, worm counts &identification, histopathology

• Networking with farmers and farm arganisations • Performing (persistent) efficacy studies for anthelmintics and effects of helminth infection on productivity (weight gain, milk production) • Development of control programmes

OSTERTAGIA AND COOPERIA CHALLENGE MODELS ACADEMIC AND REGULATORY EXPERTISE

• More than 25 years of experience in experimental and field studies to determine efficacy of anthelmintics and vaccines • Coordinator of the antiparasitic WAAVP and VICH guidelines • Member of EMA edvisory board • In depth data evoluation and interpretation of results

EXPERIENCED BSL2 LABORATORIES AND ANIMAL FACILITIES

• Performing anthelmintic (persistent) efficacy studies with susceptible and ML resistant strains according WAAVP and VICH guidelines (including early evaluation of eeficacy, comparative studies and studies for registration purposes) • Vaccine development, vaccination-challenge studies and vaccineinduced immune responses

ACADEMIC EXPERTISE

CLOSE CONTACTS WITH SWINE FARMERS:

• Consultancyby academic experts • Tailored study design • Indepth data interpretation • Ready-to-use results

• Diagnostic laboratory as a source of recent local field isolates • Field studies

PRRSV CHALLENGE MODEL

EXPERIENCED BSL2 LABORATORIES AND ANIMAL FACILITIES

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Pathogenesis studies Vaccination-challenge studies Necropsy and histopathology Quantification of virus replication upon infection and/or vacinationchalenge e.g. organs, excretions, blood Quantification of serological response to vaccination and infection e.g.

IPMA, VN Experience in vaccine develpment Genetic analysis Various in vitro models to quantify virus replication and/or determine cell tropism e.g. polarized nasel explants, macrophages/monocytes, cardiomyocytes.

VARIOUS HIGH REPRODUCIBLE IN VITRO AND IN VIVO MODELS:

ACADEMIC EXPERTISE

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SALMONELLA CHALLENGE MODEL

EXPERIENCED BSL2 LABORATORIES

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OVERVIEW of all our models per animal species and pathogen

BACTERIA

VIRUS

Actinobacillus pleuropneumoniae

PCV2

Chlamydia trachomatis

PPRSV

Escherichia coli F4/K88

SIV

Escherichia coli F18 Mycoplasma hyopneumoniae Salmonella

Escherichia coli (APEC) Campylobacter Chlamydia psittaci Clostridium perfringens ornithobacterium rinotracheale Salmonella

Escherichia coli

White spot syndrome virus

Mycotoxins in vitro and in vivo (pigs and poultry)

PARASITE Ascaris suum Tocoplasma gondii Trichuris suis

Cooperia oncophora Fasciola hepatica Ostertagia ostertagi

Toxoplasma gondii giardia duodenalis

OUR EXPERTS supervise the performance of the services and review our expert reports:

Professor dr. Eric Cox Professor dr. Edwin Claerebout Professor dr. Hans Nauwynck Professor dr. Frank Pasmans Professor dr. Filip Van Immerseel Professor dr. Daisy Vanrompay Professor Jozef Vercruysse

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CONTACT PROVAXS - University of Ghent Salisburylaan 133 9820 Merelbeke Belgium Sven Arnouts, PhD Business Developer Tel.: +32 9 264 73 33 Mob.: +32 495 707 334 Sven.Arnouts@UGent.be

Do not hesitate to contact us if you are interested to learn more about the services PROVAXS can offer.