Life enhancement sept 2014 by Life Enhancement

Your FIRST Source for Practical Scientific Health News from Around the World life-enhancement.com September 2014 $4.95

New Taurine & Bromine Formulation … Durk Pearson & Sandy Shaw’s Life Extension News … P 4 ™

The Wealth of Berberine … P 19 Who Is Will Block? … P 21 Ask Dr. Ward Dean … P 3

… you need the Mind Food™ Brain Maintenance Toolkit,™ the three-part formulation that represents a paradigm shift in the way that braincare is approached, fully parallel to the successful model for cardiovascular healthcare developed over the last few decades. What’s the point of living to 100, 110, 120, or 130 if your memories fade when you’re 90, 80, 70, 60, or earlier?

FEED YOUR HEAD…

it & W um n E h i id i IN L it p e r A M T s H e LA N GA

A brilliant idea: In order to …

Quercetin, an important polyphenol found in wine and many other foods that has been shown to inhibit and destabilize amyloid-beta* Lithium, an important brain food that is found in the bottled waters of American and European health spas … that also lowers the toxicity of amyloid-beta while causing an increase in neurotrophic factors that help induce neurons to repair themselves when under stress … that helps cause an increase in gray matter and helps enhance the neurogenesis of hippocampal neurons* DHA and EPA, essential omega-3 fatty acid brain foods that operate to prevent excessive excitation as well as enhance the body’s natural antiinflammatory protection*

Featuring:

Galantamine, with its dual mechanisms of boosting acetylcholine levels and enhancing nicotinic cholinergic activity* Choline, along with all the needed cofactors, to help maintain the brain acetylcholine levels of a young adult* Taurine, which can help protect against the deleterious effects of amyloid-beta excitotoxicity, neurotoxicity, and free radicals in your brain* Green Tea Polyphenols, a class of antioxidants, operating together as a system, that can also So get Durk Pearson & Sandy Shaw’s® personal Mind Food fight amyloid-beta toxicity* Brain Maintenance Toolkit, to be sure that you’re on track Vitamin C (as calcium ascorbate) and Vitamin E toward preserving and (as d-alpha-tocopheryl succinate), which have protecting proper memory been shown to work together to help protect and cognitive functions— your brain’s hotbeds of free radical activity* which has been one of Turmeric Curcuminoids, a system of antioxidants that Durk & Sandy’s core goals helps protect your neurons from damage or death caused all along—today!* by amyloid-beta* Folic Acid, Vitamin B6, & Vitamin B12, Omega-3 Heart & Mind 600™ GalantaMind Plus™ important vitamins that help prevent ® by Durk Pearson & Sandy Shaw damage to mitochondria (where they SUPPLEMENT FACTS SUPPLEMENT FACTS help repair DNA damage), cofactor the Serving size: 2 capsules Amount Daily Servings per container: 90 Per Serving Value production of nitric oxide, and help Serving size: 2 capsules Amount Daily Vitamin C (as calcium ascorbate) 600 mg 1000% Servings per container: 75 Per Serving Value Vitamin E (d-alpha-tocopheryl 155 IU 515% maintain normal levels of homocysteine acid succinate) Calories 13 (a neurotoxin)* Vitamin B6 (as pyridoxine) 5 mg 250% Total fat (polyunsaturated fatty acids) 1g 2%†

Memory Upgrade III™ Sugar-Free

SUPPLEMENT FACTS Serving size: 1 heaping tsp (5.7 g) Servings per container: 90

Amount Per Serving

Daily Value

Vitamin C (as niacinamide ascorbate) Vitamin E (as d,l-alpha-tocopheryl) Thiamine (vitamin B1 as thiamine hydrochloride)

36 mg 30 IU 3 mg

60% 100% 200%

Riboflavin (vitamin B2) Niacin (vitamin B3 as nicotinic acid and niacinamide ascorbate)

3 mg 75 mg

177% 375%

5 mg 100 mcg 300 mcg 500 mg

250% 1667% 100% 5001%

Calcium (as calcium pantothenate) 46 mg Zinc (as zinc gluconate) 3 mg Copper (as copper gluconate) 399 mcg Chromium (as chromium polynicotinate) 26 mcg Choline (as choline dihydrogen citrate) 1g Taurine 1000 mg Glycine 150 mg

5% 20% 20% 21% * * *

Vitamin B6 (as pyridoxine) Vitamin B12 (cyanocobalamin) Biotin Pantothenic acid (vitamin B5 as calcium pantothenate)

* Daily Value not established.

Marine lipid concentrate

1200 mg

‡

EPA (eicosapentaenoic acid)

460 mg

‡

DHA (docosahexaenoic acid)

240 mg

‡

† Percent daily values are based on a 2,000 calorie diet. ‡ Daily Value not established. Other ingredients: Gelatin, glycerin, water. Vitamin C (as ascorbyl palmitate), Vitamin E (as mixed tocopherols), and rosemary extract added to prevent autoxidation of marine (including omega-3) oils. Not a significant source of these nutrients.

Folate (as folic acid) Vitamin B12 (as cyanocobalamin) Calcium (as calcium ascorbate)

267 mcg 166 mcg 132 mg

Green tea (Camellia sinensis) leaf extract 233 mg (min 50% EGCG, 90% polyphenols) Turmeric (Curcuma longa) root 233 mg Hesperidin 100 mg Quercetin 43 mg Galantamine hydrobromide (extracted 8 mg from Galanthus nivalis) Lithium (from lithium sulfate monohydrate) 2 mg

67% 2767% 13% * * * * * *

* Daily Value not established.

Mind Food™ Brain Maintenance Toolkit™

Includes 1 to 11⁄2 month’s supply of each formulation:

GalantaMind Plus™ (180 caps, 1– 6 caps per day) Memory Upgrade III™ Sugar-Free(90 servings, 2–3 servings/day in a delicious lemon drink mix) Omega-3 Heart & Mind 600™ (150 softgels, 2 softgels per serving)

Factory Direct Prices $118.97 $45.97 $26.97

If bought as the Toolkit . . . $163.47 Save $28.44

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

September 2014 Editorial

2 The Door into Summer

Page 5

Health Matters

Introducing DURK & SANDY’S “ESSENTIALS,” including their …

3 Ask Dr. Ward Dean • Help for Post-Stroke Cerebral Insufficiency

3 Brief Summaries of Leading Articles in this Issue

Designing Your Life Extension Program: Why NO LE Program Should Be Without VeryLow-Cost High-Benefit TAURINE Durk Pearson & Sandy Shaw

Durk Pearson & Sandy Shaw®

You too can develop the Midas touch and add to your health ledgers with …

4 Life Extension News™ Vol. 17 No. 8 • September 2014 1. Taurine protects against Glutamate Neurotoxicity 2. Taurine promotes Neurogenesis 3. Taurine protects against amyloid beta’s role in the development of Alzheimer’s Disease 4. Taurine protects against decline of Kidney Function, a major “gotcha” with advancing age 4A. Taurine suppresses Liver Damage 5. Taurine may lower risk of Cardiovascular Disease 6. Taurine protects against Cardiac Arrhythmias 7. Taurine decreases Platelet Aggregation. 8. Taurine protects against Ischemic Stroke 8A. Taurine protects against Decline of Cholinergic Nervous System 8B. Taurine protects against Type 2 Diabetes 9. Taurine improves chronic Periodontitis 10. Noises in your head? Taurine reduces Tinnitus, improves Auditory Discrimination 11. Taurine protects against Radiation as well as radiation-induced immune suppression 12. Taurine has Antinociceptive (anti-pain) effects 13. The essential trace element Bromine—why you need a bromide supplement 14. Antiinflammatory and Antibacterial effects of the naturally formed Taurine bromamine 15. Taurine brings the dead back to life (just kidding) 16. How To Use the New Taurine/Bromine formulation Exercise Your Brain

26 Here’s to Your Health! CALL 800-543-3873

5 New Taurine & Bromine Formulation

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19 The Wealth of Berberine

Berberine Research Continues to Unfold Will Block

Who Is Will Block?

21 A Human Perspective on a Visionary Mind Dr. Joyce Block

Available Online Product Guide

We have a complimentary 56-page Product Guide with additional information about many of our bestselling products. Download it today: www.life-enhancement.com/ documents/LEP_catalog.pdf

Ingredients Index Our comprehensive index of ingredients in our products is now easier to access on our improved Web site. (See it on the right side of the home page). We hope this list will prove useful to you in gaining further insight into the ways in which many natural substances can be beneficial to your health. www.life-enhancement.com

SEPTEMBER 2014

Editorial

Product Advertising Index

The Door into Summer

s the final days of summer are drawing to an end, I’m reminded of Robert A. Heinlein’s science fiction novel, The Door into Summer, a favorite of mine that has all the key elements of a good read: a dash of fantasy along with a large dollop each of romance and science. The story involves an inventor, a cat, robots, and time travel. And gladly, it has a happy ending, which for the protagonist is a new happy beginning. And that’s the spirit that should propel us forward, and keep us constantly in the season of Summer where, rather than wallowing in aging metaphors, we take full advantage of the growing wealth CONTINUED ON PAGE

Berberine Grape Power™ . . . . . . . . . . . . . . .17 BLAST™ family* . . . . . . . . . . . . . . . . . . . . . .C3 DMAE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .17 GalantaMind™ Plus* . . . . . . . . . . . . . . . . . .C2 Greater Rewards™* . . . . . . . . . . . . . . . . . . .C4 InnerPower™* . . . . . . . . . . . . . . . . . . . . . . .32 InsuLife-B™† . . . . . . . . . . . . . . . . . . . . . . . . .17 Memory Upgrade III™* . . . . . . . . . . . . . . . .C2 Mind Food™ Brain Maintenance Toolkit™* .C2 Omega-3 Heart & Mind 600™* . . . . . . . . . .C2 Taurine ’n More™* . . . . . . . . . . . . . . . . . . . .18 ThyroPlex™† . . . . . . . . . . . . . . . . . . . . . . . . .C3 Turmeric Root Power™* . . . . . . . . . . . . . . . .25 * by Durk Pearson & Sandy Shaw® † by Jonathan V. Wright, M.D.

See Product Guide, page 27

NUTRITIONAL SUPPLEMENTS TO ENHANCE YOUR QUALITY OF LIFE Innovation Is Our Driving Force

We were the first company to market DHEA, making it commercially available in 1995. We were also first to market pregnenolone, 5-HTP, vinpocetine, mastic gum, the world’s first DNA-support supplement, galantamine, and MHCP. We’ve been out there “pushing the envelope” and building acceptance for the enhancement of life since 1985, when the concept of life extension supplementation first gelled. Often we hear from doctors that they really appreciate what we’re doing in this field.

Quality Control Is Paramount

The raw materials we purchase for our products are the safest, highest-quality, pharmaceutical-grade ingredients available in the world. We package under the purest possible clean-room conditions, and materials undergo lab testing to confirm purity greater than 98% (or we reject them).

Advisor Biographical Notes

Dr. Jonathan Wright is the best-selling author of Dr. Wright’s Guide to Healing with Nutrition, Dr.Wright’s Book of Nutritional Therapy (over 600,000 copies sold), Maximize Your Vitality & Potency for Men Over 40, and Natural Hormone Replacement for Women Over 45. He is the medical director of the Tahoma Clinic in Tukwila, Washington and publisher of his own newsletter, Nutrition & Healing. Dr. Don Kleinsek is president of GeriGene, Inc., a Wisconsin biotech company devoted entirely to life extension through gene therapy. Dr. Kleinsek was the hand-chosen successor to life extension pioneer Dr. Johan Bjorksten as President and Director of the Bjorksten Research Foundation. According to two-time Nobel laureate Linus Pauling, Dr. Bjorksten was an innovator and “one of the most active and effective students of longevity in the world.” Will Block is a researcher, writer, and speaker specializing in the life extension, life enhancement, and cognitive enhancement aspects of nutritional science. His writings have appeared widely in newsletters, magazines, and books. He is also the author of The 5-HTP Archives and Tools for Privacy, a book about public-key encryption, and he speaks about futurology, nootropics, nanotechnology, and freedom.

L I F E enhancement

SEPTEMBER 2014

Publisher/Editorial Director Will Block Art Director Paul Dushkind Medical Editor Ward Dean, M.D. Medical/Scientific Don Kleinsek, Ph.D. Advisors Michael Rosenbaum, M.D. Gary Ross, M.D. Jonathan Wright, M.D. All materials in this publication are provided for informational purposes only and should not be construed as medical advice or instruction. You are cautioned not to begin, alter, or discontinue a health regimen based only on the contents of this publication. You are advised to consult with appropriate health professionals on any matters related to your health and well-being. You should not use the information in this publication for diagnosis or treatment of any health problem or alter your use of prescription medications or other treatment. You should not stop or alter your use of any medication without first consulting your treating physician. The opinions and information provided in this publication are believed to be accurate based on the best judgment of the editors and authors. The publisher is not responsible for errors or omissions. © 2014 Life Enhancement Products, Inc. 2555 Business Parkway, Minden, Nevada 89423 All rights reserved.

Health Matters

Ask Dr. Ward Dean Help for Post-Stroke Cerebral Insufficiency

Dear Dr. Dean, My husband suffers from short-term memory loss due to strokes in Jan 2006 and again in 2012. He converses with people easily, but cannot recall what was said later in the day. He is 74 years old. His health is good. He has high blood pressure controlled by meds. He sleeps well. He is about 35 pounds overweight. What are your recommendations? What Life Enhancement products would be helpful? ROSANNE, Belemont, AZ Dear Rosanne, It sounds as if your husband is suffering from Mild Cognitive Impairment (MCI), resulting from ischemic injury from a stroke. Although there’s no “silver bullet,” and no guarantees from any treatment, I suggest a number of approaches that may provide some relief and improvement: Vinpocetine Vinpocetine is an extract of the periwinkle plant, developed as a cognitive enhancer in Hungary over 30 years ago. It acts to increase cerebral blood flow, reduce blood viscosity, and increase the utilization of glucose and oxygen in the brain. One of the earlier human studies on vinpocetine involved 42 patients with “chronic vascular senile cerebral dysfunction” (i.e., mild-to-moderate dementia caused by inadequate blood flow to and within the brain).1 After taking 10 mg of vinpocetine three times/day for one month, followed by two-months of 5 mg three times/day, researchers

noted improved general cognition of the patients. They concluded that vinpocetine improves memory, learning, and speech and language skills in patients suffering from vascular dementia. More recently, researchers in Portugal also demonstrated that vinpocetine protects against neuronal ischemic injury in humans;2 and in Russia, ischemic stroke patients treated with 10 mg of vinpocetine three times/day for three months fared better than the control group on a National Institute of Health standardized Stroke Scale.3 A recent review article concluded that, “Vinpocetine is widely used in Japan, Hungary, Germany, Poland and Russia for the treatment of cerebro-vascular-related pathologies. Clinical studies have indicated the efficacy and safety of Vinpocetine as a neuroprotective, nootropic and anti-convulsant agent.”4 Vinpocetine has no known adverse effects, and is effective in doses of 20–40 mg per day. Acetyl-L-Carnitine (ALC) ALC is important for energetics in the brain and other tissues. ALC transports fatty acids from the cell cytoplasm into the mitochondria where they play a critical role in the generation of adenosine tri-phosphate (ATP), the body’s universal energy molecule. A number of studies of the effect of ALC on patients suffering from cerebrovascular ischemia—including many who had suffered strokes—were performed in the early 1990s.5–9 These studies demonstrated ALC’s ability to improve cerebral blood flow and memory and reaction CONTINUED ON PAGE

BRIEF SUMMARIES OF LEADING ARTICLES IN THIS ISSUE New Taurine-Bromide Formulation

The Wealth of Berberine

The amino acid taurine is a multi-talented nutrient that has been shown to offer a wide-spectrum of health benefits. It protects against glutamate toxicity in the retina, promotes neurogenesis and guards against neurotoxicity associated with amyloid beta, strengthens the health of the kidneys, and protects against fatty liver and acetaminophen-induced damage. Plus, taurine may have beneficial effects in the treatment of alcoholism, hypertension, ischemic heart disease, atherosclerosis, diabetic cardiomyopathy, tinnitus, and type 2 diabetes. Combine taurine with the essential trace element bromide and you have an even more effective nutritional tool at your disposal that fights bacteria, inflammation, acne—and more. To read more about these two impressive nutrients, turn to page 5.

Perhaps it's no coincidence that the herbal extract berberine has a golden color. Research has shown it provides a wealth of health benefits. In the last few years, study after study has confirmed berberine to have multiple bioactivities, including cholesterol-lowering, anti-insulin resistance, anti-diabetes, cardiovascular protection, anti-inflammation, and anti-cancer properties. And that’s not all! Recent studies have found that berberine can fight dementia and Alzheimer’s disease along with improving memory. Berberine also stops leukocytes from killing retinal endothelial cells in diabetes, reduces ulcer size in recurrent aphthous stomatitis, and it may improve insulin resistance in women with polycystic ovary syndrome. To read more about why berberine is a valuable addition to any supplement regimen, read the article on page 19.

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Durk Pearson & Sandy Shaw’s® CONT. FROM PAGE

time in a variety of tests. In 2003, a meta-analysis of randomized double-blind studies of the effect of ALC on mild cognitive impairment and early Alzheimer’s was conducted.10 The results showed a significant benefit for ALC in both clinical scales and psychometric tests. The beneficial effects were evident by 3 months, and continued over time. The dosages used in all of the studies ranged from 1.5–3.0 gm per day, with no adverse effects reported. Ginkgo biloba Extract (GBE) Ginkgo biloba has been used traditionally in Asia for its ability to normalize blood pressure, increase libido, and improve cognitive performance in normal adults as well as those suffering from cognitive impairment. GBE is considered a drug in Germany, where it is one of the most widely prescribed drugs. It is also very popular in France and the Netherlands. In 1992, a rigorous meta-analysis was published in the British Journal of Pharmacology in which the authors reviewed 40 trials of Ginkgo biloba extract in cerebral insufficiency.11 The study examined the effects of GBE on 12 symptoms of cerebral insufficiency. All but one of these 40 trials reported positive effects of GBE on these symptoms. The authors cautioned that it may take 4–6 weeks of treatment before improvement is noted. The most commonly used dose in the studies was 120 mg GBE daily. In the same year, a German double-blind study of 72 patients with cerebral insufficiency treated with GBE or placebo found a statistically significant improvement in short term memory after 6 weeks.12 The authors concluded that, “GBE improves mental performance.” Two recent studies confirm the clinical improvement of patients with acute and chronic cerebral ischemia. The first, from Iran,13 and the second, from Russia.14 Both papers report significant improvement in patients suffering from acute or chronic cerebral insufficiency. I recommend GBE doses of 240 mg per day. DMAE One of the first substances Life Enhancement carried is DMAE (dimethylaminoethanol). DMAE is not known (to my knowledge) to help with cerebral insufficiency, but it does act as a mild cerebral stimulant, helps to elevate mood, improve memory and learning, heighten intelligence, increase physical energy and—in laboratory animals—extend the life span. DMAE probably works by accelerating the brain’s synthesis and turnover of the neurotransmitter acetylcholine, which in turn plays a key role in maintaining mental ability as well as supporting healthy memory in aging adults. It has also been suggested that DMAE may work, in part, by inhibiting choline metabolism in peripheral tissues, causing free choline to accumulate in blood, enter the brain, and stimulate cholinergic receptors.15,16 CONTINUED ON PAGE

L I F E enhancement

SEPTEMBER 2014

Life Extension News

™

Vol. 17 No. 8 • September 2014 Theory guides; experiment decides. — motto of analytical chemist Izaak Maurits Kolthoff Theory is a good thing, but a good experiment is forever. — Peter Leonidovich Kapitza, Soviet physicist The future is already here—It’s just not very evenly distributed. — William Gibson, science fiction author iFOIA, New Resource from the Reporters Committee for Freedom of the Press Online Tool to Create, Send, and Track Federal and State Freedom of Information Requests

For those wanting to get information via the FOIA or Privacy Act, this is a website set up especially to help you do that. You can even deliver your FOIA request to the relevant agency with the help of iFOIA. iFOIA can be found at www.ifoia.org. At www.rcfp.org, you can also get help from their Federal FOIA Appeals Guide. Uncovering and bringing to public attention the illegal goings on at Federal agencies is one of the best ways to help fight back. ©2014 by Durk Pearson & Sandy Shaw

Introducing DURK & SANDY’S “ESSENTIALS,” including their …

New Taurine & Bromine Formulation Designing Your Life Extension Program: Why NO LE Program Should Be Without Very-Low-Cost High-Benefit TAURINE Our New TAURINE Formulation Also Contains the Essential Trace Mineral BROMINE (as Bromide) Natural TAURINE-BROMINE Compound Made in Your Body Is Potent Antimicrobial AND Antiinflammatory

here are a very large number of dietary supplements on the market. The choice is certainly there, but since nobody can (or should) try to take everything, it leaves the difficult problem of picking and choosing the supplements that fit within your budget AND represent the most important elements to include in your personal program to increase health and lifespan. We hope to make this a little bit easier by identifying specific supplements—that we call ESSENTIALS—for their exceptional importance in a program (including ours) for health and long life. These are basic supplements for any well-designed health program and, as you will see, you don’t have to spend a lot for the ESSENTIALS. The amino acid TAURINE is one of our ESSENTIALS, and represents a great value: for a low price, you get a nutrient that provides a dazzling array of health benefits throughout your body and brain.1 Plus, we include BROMINE (in the form of bromide), long suspected of being an essential trace element3 and now definitely shown to be essential,4 as it is required for proper assembly of collagen IV scaffolds crucial for organogenesis (development of organs). One paper notes that BROMINE deficiency “may be relevant to BM [basement membrane] alterations observed in nutritional and smoking-related ©2014 by Durk Pearson & Sandy Shaw

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diseases.”5 Another paper names diseases in which collagen IV scaffold is reported to be dysfunctional.6 More on BROMINE later in this article. Here we describe some of what researchers have uncovered about TAURINE. To your health! Taurine has been the focus of a considerable body of research. From 1927 to date, there have been 16,221 papers published on taurine. In 2013, 560 papers on taurine were published, 493 papers in 2012, 414 papers in 2011, 471 in 2010, and to date (July 14, 2014), 264 papers have been published with about another 51⁄2 months left in 2014. TAURINE and Glutamate Neurotoxicity

A recent review paper1 provides a 13-page description of many of taurine’s effects, with 171 references. The authors start by describing a puzzling observation, that the administration of glutamate given at neurotoxic doses caused damage to every part of the central nervous system but that in the mouse neonatal retina bathed in glutamate, only the inner layers were seriously affected. The authors1 suggest that it is taurine (found in high concentrations in the retina) that is a likely source for at least some of the protection against high dose glutamate toxicity. As they point out, quantitative analysis has shown that in extracts of whole ocular tissue of the rat eye, taurine was the most abundant amino acid in the retina, vitreous, lens, cornea, iris, and ciliary body. Remarkably, in the normal (control) retina, taurine exceeds the concentration of each of the other amino acids by tenfold or more. Experimental studies of primary www.life-enhancement.com

SEPTEMBER 2014

neuronal cultures from the fetal rat brain have shown that taurine inhibits glutamate toxicity by a number of different mechanisms.1 The reviewers assert: “[b]ecause it is one of the few amino acids not used in protein synthesis, taurine is often referred to as a ‘nonessential’ amino acid, or more generously as a ‘conditionally essential’ amino acid. Considering its broad distribution, its many cytoprotective attributes, and its functional significance in cell development, nutrition, and survival, these are clearly misnomers. Taurine is undoubtedly one of the most essential substances in the body.”1 [Emphasis added.] TAURINE Promotes Neurogenesis

One of the most important effects of taurine is its crucial role in neurogenesis, the production of new neurons that takes place only in specific brain areas of adult mammals throughout life.1 The review describes the function of taurine in this process: “[o]f particular interest is the fact that within the subventricular zone of the cultured adult mouse brain, taurine activates stem cells and neural precursor cells to differentiate into neurons rather than astrocytes [another type of brain cell]. The subventricular zone is one of the few regions in the brain in which neurogenesis continues throughout adulthood, and the cells from this region can proliferate and migrate via the rostral migratory stream to the olfactory bulb where they differentiate into neurons. Considering the high taurine content in the adult [mammalian] olfactory bulb, it is likely that taurine is an important factor for neurogenesis.” Further substantiation for this view is provided by in vitro studies showing that taurine promotes putative rod and cone photoreceptor development.1 TAURINE May Be Cytoprotective Against Amyloid Beta to Ameliorate Development and Progression of Alzheimer’s

Mounting evidence points to a causative role of amyloid beta accumulation in Alzheimer’s disease; it has also been linked to other neurodegenerative disorders such as Huntington’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, AIDS dementia complex, and brain cell death as a result of excitotoxicity, hypoglycemia, neurologic trauma, stroke, and epilepsy.6 “We show that taurine, a beta-amino acid found at high concentrations in the brain, protects chick retinal neurons in culture against the neurotoxicity of amyloid beta and glutamate receptor agonists.”6 The authors propose that selective pharmacological modifications such as those observed for taurine might offer an “interesting therapeutic approach” in many neurological disorders, including Alzheimer’s. 6

L I F E enhancement

SEPTEMBER 2014

The source of the neurotoxicity associated with amyloid beta is, at least in part, due to excitotoxicity caused by overactivation of glutamate receptors.7 Experiments in rat neuronal cultures showed that taurine could block the neurotoxicity of amyloid beta (which caused about 45% neuronal cell death in control cultures) even at the lowest concentration tested (0.5 µM).7 Taurine is an agonist of (activates) GABA receptors. The researchers added a GABA receptor antagonist to the cultured neurons treated with amyloid beta and taurine. They found that the GABA antagonist abolished the protective effects of taurine, confirming that the taurine protection was due to its activation of GABA receptors. These results show that overactivation of glutamate receptors are likely to play an important role in the neurotoxic effects of amyloid beta. The researchers also showed, using the same cell culture model, that taurine could block the neurotoxicity of glutamate added to cortical neurons and, again, addition of the GABA receptor antagonist abolished the protective effects of taurine against glutamate excitotoxicity. The researchers7 concluded that GABA receptors play an important role in preventing amyloid beta neurodegeneration and “[m]ore importantly, they [the experimental results] indicate that the possible efficacy of taurine in the clinical treatment of AD [Alzheimer’s disease] should be further investigated.” TAURINE Protects Against Age-Associated Decline in Kidney Function, a Major Source of Morbidity and Mortality

Decline of kidney function is a major accompaniment of aging and is an important risk factor for mortality. Failure of the kidneys can be corrected only by dialysis or by kidney transplants, both of which are life shortening and cause considerable loss of quality of life. Dialysis, for example, is not only unpleasant but it does not provide results that duplicate what functioning kidneys do. Acute kidney injury frequently accompanies sepsis, toxic injury, and shock.8 Chronic kidney damage is the major reason for requiring dialysis in end-stage renal (kidney) disease (renal nephropathy) that often occurs as a life-threatening complication in diabetes mellitus. In an analysis of 942 community-dwelling elderly adults (mean age: 75 years) participating in the InCHIANTI study, researchers examined the predictability of survival based on different equations for estimating kidney function.9 The results showed that kidney function was a strong independent predictor of death over a six-year followup in this group, thought to be representative of the Italian population. Other studies also show that mild to moderate kidney dysfunction is associated

with risks of all-cause mortality and cardiovascular disease, both morbidity and mortality.9 “… there appears to be little question that the prevalence of CKD [chronic kidney disease] is high in elderly people and is strongly associated with risk of death.”9 Mechanisms of TAURINE in the Kidneys

• Antioxidant Protection The major mechanism of taurine’s antioxidant protection against kidney damage was proposed to be taurine’s reactions to scavenge hypochlorous acid (BLEACH!), a potent oxidant metabolite of myeloperoxidase.8 The product of taurine’s chemical interaction with hypochlorous acid is, interestingly, taurine chloramine, which is both an antibacterial and an inflammatory.12,24 (Similarly, taurine chemically interacts with hypobromous acid (another oxidant metabolite of myeloperoxidase) to form taurine bromamine, also with antibacterial and antiinflammatory properties). • Protection Against Ischemia-Reperfusion Injury As with other tissues subject to ischemia (reduction of blood flow and, hence, reduced oxygen supply) and then reperfusion (restoration of blood flow), the kidneys can be severely injured by ischemia followed by reperfusion. Experimental studies in cell cultures and animal models of ischemia-reperfusion have demonstrated protective effects by taurine. For example, a study of diabetic nephropathy in a type 2 diabetic rat model8C examined rats divided into three groups: a control group, a group treated with high glucose levels (30 mM) to induce a diabetic state (diabetic controls), and a diabetic group treated with taurine (200 mg/kg/day for 20 weeks). (This dose is very roughly equivalent to 1 gram of taurine per day for an adult human.) Markers of diabetic nephropathy include increased expression of growth factors such as vascular endothelial growth factor and changes in the kidney glomerular basement membrane, which thickens in diabetic nephropathy. There is also increased oxidative stress and fibrosis. Results included significantly decreased fasting blood glucose levels in the taurine-treated diabetic group as compared to the diabetic controls; blood glucose levels were significantly increased in the diabetic controls as compared to the normal controls. Interestingly, adiponectin (which increases insulin sensitivity) was significantly decreased in the diabetic control group compared to the normal control group and increased in the taurine-treated diabetic animals (though not to a statistically significant level). “The thickness of the GBM [glomerular basement membrane] was increased in the diabetic control group compared to the normal control group, and significantly decreased in the taurine-treated diabetic group, approaching that of the normal control group.” Urinary malondialdehyde (a lipid peroxidation product of oxidative stress) was lower in the taurinetreated diabetic group than the diabetic control group. CALL 800-543-3873

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• Protection Against Fibrosis The protection by taurine against increasing glomerular basement membrane thickness (as seen in the taurine-treated diabetic rats described above) is an antifibrotic effect of taurine. Fibrosis is seen in a great many diseases of aging, such as in the heart following heart attack. Taurine reduced the production of lung fibrosis by radiation in C57/BL6 fibrosis-prone mice.20 The authors8C concluded that taurine is “another candidate for the treatment of diabetic nephropathy.” [Emphasis added.] Keep in mind here that taurine is a safe nutrient, widely available and very inexpensive compared to other “candidate” treatments for diabetic nephropathy, which can be a major advantage in hard economic times. You don’t even need a doctor’s prescription—though we suggest that you consult regularly with a doctor knowledgeable about nutritional therapy to help you in keeping track of your results, arranging for lab tests and interpreting them, and to advise you concerning unexpected events (which can happen without warning if you have a serious medical condition such as type 2 diabetes). • Protects Kidneys from Osmotic Stress, Such as Hyperglycemia Taurine is a major regulator of cellular response to osmotic stress (termed “cell volume regulation”) in the kidneys. As such, taurine is importantly involved in protection in the kidneys under conditions of hypo- or hypernatremia (low or high levels of sodium) or when exposed to conditions of hypoglycemia or hyperglycemia. (Interestingly, taurine is involved in the adaptation of fish when they go from fresh water to sea water or vice versa.)8 As shown in Figure 4,8 taurine moves out of cells exposed to hypotonic solutions, while entering cells exposed to hypertonic solutions. TAURINE Protects the Liver From Acetaminopheninduced Liver Failure TAURINE Protects the Liver Against Fatty Liver and Against Injury-Induced Development of Fibrosis Liver Disease Is One of the Leading Causes of Death Worldwide21

Your liver provides an important first level of defense against the damaging effects of drugs, pollutants, toxins, and substances consumed with food or water. As a result, the liver is exposed to a wide variety of carcinogens, mutagens, and other damaging agents that it has to metabolize to a form that can be quickly excreted. That can involve, for example, converting a chemical into a water soluble form for excretion via the urine. Taurine is an important protective substance that helps prevent liver damage from occurring during the performance of the liver’s detoxification function.8D It also helps prevent the development of liver fibrosis and/or fatty liver that can occur as a common response to chronic liver injury.8D,8F The www.life-enhancement.com

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researchers8D identified the protective mechanism as being the inhibition of proliferation of hepatic stellate cells which generate the extracellular matrix that makes up the fibrotic tissue in the damaged liver. Another paper,8E noting the acetaminophen (an antipain drug)-induced liver failure that can result from overdose, studied Swiss albino male rats that were treated with acetaminophen (APAP) to cause liver failure following 1, 2, 3, 4, or 5 days of pretreatment with taurine (150 mg/kg body weight) or no taurine. (This taurine dose is roughly equivalent to a little less than one gram per day for an adult human.) In animals receiving APAP but not receiving taurine, liver enzymes (as detected by measurement of serum ALT, ALP, LDH, and NO) were dramatically elevated. These measures were significantly reduced by pretreatment with taurine. APAP was also shown to increase lipid peroxidation in the liver, but this was significantly inhibited by taurine pretreatment. Importantly, liver glutathione levels were rapidly depleted in the APAP treated rats, but taurine treatment before and after APAP administration significantly protected against this effect—apparently by directing cysteine into the glutathione synthesis pathway. The researchers note that CYP2E1 is the form of CYP450 that catalyzes the metabolism of APAP to the liver-toxic NAPQ1, and that taurocholic acid, formed in the body by the reaction of taurine and cholic acid, is a potent inhibitor CYP2E1.8E Increased levels of TNF-alpha (tumor necrosis factor alpha) play an important role in liver injury, such as that resulting from ischemia-reperfusion and fulminant liver failure. APAP treatment caused increases in TNF-alpha in the experimental rats, but treatment with taurine either before or after APAP administration significantly decreased TNF-alpha as compared to the APAP rats not receiving taurine. The researchers emphasize that acetaminophen can be used safely for reduction of mild to moderate pain at the normal dose (as specified on the label) but it doesn’t have a large therapeutic index (the ratio of the toxic dose to the therapeutic dose), meaning that it is important not to exceed the recommended dose or to use it chronically. MOREOVER, IT IS IMPORTANT TO KNOW THAT EVEN A SINGLE DAILY ALCOHOLIC DRINK TAKEN IN CONJUNCTION WITH THE REGULAR USE OF ACETAMINOPHEN INCREASES THE RISK OF LIVER INJURY. We suggest avoiding acetaminophen entirely. It is unfortunate that the drug is often combined with hydrocodone in pain killers prescribed by dentists for toothaches! The researchers8E conclude that: “… taurine deserves further consideration as a potential alternative for preventing liver injury caused by acetaminophen-overdose.” Importantly, acetaminophen-induced liver injury is the most common cause of poisoning requiring hospitalization in the U.S. 8

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TAURINE Protects Against Fatty Liver

A common complication of type 2 diabetes is fatty liver. Taurine treatment protects against the development of fatty liver in hamsters on a high fat/cholesterol dietary regime.8F Interestingly, the LDL receptor gene expression was increased in the hamsters. The LDL receptor is important in transporting serum cholesterol to the liver for its clearance from the bloodstream. If you are taking a variety of dietary supplements, herbs, and medicinal drugs, we recommend that you have regular lab tests for kidney and liver function to make sure these organs are functioning normally. They are involved in the metabolism and excretion of everything that enters your body in order to maintain blood concentrations of a wide variety of constituents at closely regulated levels. You only get one liver. Unlike the kidneys, where if worst comes to worst you can survive on dialysis (though it really cannot closely mimic what a normal kidney does), you can’t survive without a liver—and getting a liver transplant and the immunosuppressive regime that goes with it is life shortening. TAURINE and Cardiovascular Disease

Human clinical studies review taurine’s beneficial effects in the treatment of alcoholism, hypertension, ischemic heart disease, atherosclerosis, and diabetic cardiomyopathy.2,2A However, the purported “gold standard”—a longterm randomized double blind trial of taurine and the treatment of one or more of these diseases—has not yet been carried out. The authors of one of the reviews2 note that in the absence of such a trial, taurine cannot be “unequivocally” recommended as a nutritional intervention for the prevention or treatment of cardiovascular disease. As such studies are costly, take several years or more, and have been performed with other important nutrients in a limited number of large human interventional trials without coming to an “unequivocal” conclusion, one doubts very much that such a trial would deliver the desired conclusive proof that everyone seems to be looking for. Even the much-touted FDA-approved drugs, having undergone large randomized double blind clinical trials in order to receive FDA approval, are rarely conclusive, as treatment benefits compared to risks will vary as a result of individual differences (which is why subgroup analysis is so important). Also, it is not uncommon for unforeseen adverse effects to show up only after drugs reach the market. For a nutrient such as taurine that cannot be patented, it is unlikely that large, expensive clinical trials would ever be funded. However, there is a fairly large and growing literature available on taurine’s mechanisms, on taurine’s effects in animal models of human disease, as well as taurine treatment in short-term human clinical trials, and, importantly, extensive evidence of nontoxicity of taurine at low doses to doses of several grams a day.

Subgroup Analysis Tells the Story: Significant Inverse Association between Serum TAURINE and Coronary Heart Disease Risk in Women with High Serum Cholesterol

In a nested case control study8B of 223 coronary heart disease patients and 223 matched controls (participants in the New York University Women’s Health Study) where serum taurine had been measured BEFORE the appearance of coronary heart disease, the researchers evaluated the association of serum taurine levels and the risk of developing coronary heart disease. Overall, there was no statistically significant association between the risk of coronary heart disease (CHD) and serum taurine levels. But, in considering just the subgroup of women with high total serum cholesterol (>250 mg/dl), there was a significant inverse association between serum taurine levels and CHD. Keeping in mind that taurine would be just one of the factors involved in CHD risk, the study supports the hypothesis that taurine may be protective against cardiovascular disease. TAURINE May Protect Against Arrhythmias SUDDEN CARDIAC DEATH

Sudden cardiac death is associated with a number of cardiovascular conditions, such as arrhythmias following heart attack and, in the case of heart failure, 50% of patients are estimated to die of fatal cardiac arrhythmias.10 Mechanisms of taurine that could contribute to protection against cardiac arrhythmias include membrane stabilization and prevention of intracellular calcium (Ca2+) overload.2 Taurine has also been reported to suppress the sympathetic nervous system,2 excessive activation of which can cause arrhythmias. Taurine depletion has been linked to electrical and contractual abnormalities (such as increased excitability) in skeletal muscle (different from cardiac muscle) of aged rats; taurine supplementation (1 g taurine/kg/day) improved these measures, moving them toward more normal adult values.10 (This dose in rats is roughly equivalent to 4 to 5 grams per day for an adult human.) TAURINE Regulates Sensitivity of Platelets to Aggregation

Reference #2 discussed the sensitivity of platelets to aggregation-inducing stimuli under conditions of taurine depletion, normal amounts of taurine, or taurine supplementation. Taurine-depleted cats, for example, were reported to be twice as sensitive to platelet aggregation (clotting) as cats receiving adequate amounts of taurine. In humans with normal taurine status, supplementation with extra taurine (400 mg/day or 1600 mg/day) reCALL 800-543-3873

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sulted in platelets having increased resistance to aggregation by 30% or 70%, respectively. Thus, the tendency of platelets to aggregate is depressed by taurine. Fatal dilated cardiomyopathy can be prevented in both cats and dogs by taurine supplementation.2 Commercial cat and dog food generally contains adequate amounts of taurine to prevent the development of this condition—something that has been known for quite a long time, so your pet doesn’t end up at the veterinarian emergency room with a possibly fatal case of heart failure. Inflammation Linked to Coagulation

As the authors of another paper10K explained, “… increased inflammation may derive from increasing activation of the coagulation system with age. Coagulation may be considered part of the inflammation system with many shared components and strong interactions. The increased hypercoagulable state observed with aging may account for the higher incidence of arterial and venous thromboses in elderly persons.” TAURINE’s Mechanisms for Protection against Ischemic Stroke

In a rat model of ischemic stroke (middle cerebral artery occlusion),10B researchers administered 50 mg/kg of taurine (intravenously) one hour following the induction of ischemia. Taurine treatment markedly reduced the observable effects of stroke, including neurological deficits, brain swelling, and cell death, and resulted in decreased infarct volume (cells killed by ischemia) 72 hours after the induction of ischemia. Inducers of stroke damage importantly included upregulation of PARP (poly(ADP-ribose)polymerase), a major enzyme that responds to DNA damage, and upregulation of NFkappaBinduced inflammation. These changes were reversed by taurine. The study10B also reported that taurine reduces the expression of a number of inflammatory cytokines (such as tumor necrosis factor alpha), as well as reduces the activity of myeloperoxidase, a major source of stroke injury.10C Researchers used the middle cerebral artery occlusion model of stroke in rats to investigate a drug that is a specific PARP inhibitor for its possible protective effects against stroke.10D Results were consistent with those for taurine in the study described above;10B PARP inhibition protected neurons and white matter from stroke injury and death, and prevented the translocation of apoptosisinducing factor (AIF) to the nucleus where it unleashes its program of cell death. PARP is the subject of a rapidly growing body of research as it is importantly involved not only in response to DNA damage, but mild inhibition of the enzyme may be a potential anti-aging treatment.10E,10F www.life-enhancement.com

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PARP overactivation during DNA damaging events such as strokes can deplete cellular supplies of NAD+, resulting in cellular energy deprivation and thus stressing damaged cells even further. [See “It’s a NAD+, NAD+, NAD+, NAD+ World” in our Life Extension News, September 2013 and “It’s a NAD+, NAD+, NAD+, NAD+ World,” Part II, in our Life Extension News, November 2013.] TAURINE Protects Against Cognitive Decline by Preventing Excitotoxic Cholinergic Dysfunction

Cholinergic dysfunction as a contributory factor to cognitive decline with age and to the development of Alzheimer’s disease are areas of extensive research. Choline acetyltransferase, the enzyme required to convert choline to acetylcholine, has been reported to be inhibited as a result of the action of excitatory amino acids.10G Since taurine is well known to provide protection against excitotoxicity (such as that caused by excessive levels of glutamic or aspartic acids), it is a plausible hypothesis that it may help protect choline acetyltransferase from the negative effects of excitatory amino acids. In paper #10G, researchers studied the effects of excitotoxic amino acids on retinas from 8 – 9 day old chick embryos. Exposure to 15 hours of treatment with kainate or glutamate resulted in maximal inhibition (80 – 90%) of choline acetyltransferase, reducing the activity of the enzyme rather than reducing its cellular content. As noted above, taurine6 has been shown to protect against neurotoxicity induced by amyloid beta and glutamate receptor agonists. This supports the proposed protection by taurine against the cholinergic dysfunction (inhibition of choline acetyltransferase) caused by glutamate and kainate. Along that line, another paper10H reported that inhibition of choline acetyltransferase was a mechanism for the cholinergic dysfunction induced by amyloid beta peptide oligomers. TYPE 2 DIABETES TAURINE and Fish Oil Decrease Fat Accumulation, Improve Glucose and Insulin Levels in Type 2 Diabetic Mice

Researchers tested the effects of EPA- and DHA-rich fish oil and taurine in a diabetic/obese KK-A(Y) mouse model of type 2 diabetes.10J Because both taurine and fish oil have exhibited protective effects against type 2 diabetes, and because the combination had been reported in very few studies, the researchers decided to examine the effects of the agents singly and in combination. The animals were put on an experimental diet for 4 weeks. The diets contained the basal ingredients plus soybean oil or fish oil supplemented with 0%, 2%, or 4% taurine. The results showed the fish oil plus 4% taurine diet suppressed WAT (white adipose tissue) weight gain and reduced blood glucose and insulin levels. The 10

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WAT weight gain in the mice receiving the fish oil plus 4% taurine diet was significantly lower than that in the mice fed fish oil alone. Moreover, blood glucose and insulin levels in the mice fed the fish oil + 4% taurine diet were the lowest among the six groups. The researchers identified inhibition of fatty acid synthesis and promotion of beta oxidation (metabolism of fat) in the liver as one of the reasons for the decreased WAT weight gain in the animals fed fish oil and taurine. TAURINE Improves Condition of Patients with Chronic Periodontitis

We add here an example of taurine’s amazing versatility as a broadly protective nutrient: a study showing improvements in 10 nonsmoking male patients with chronic periodontitis.17 Periodontitis is a disease that involves infection and inflammation, among other problems. The researchers cited prior related work: one study described a topical application of 1% taurine on two basement membrane proteins (laminin 5 and type IV collagen expressions) of regenerating oral gingival epithelium provided histologic evidence of rapid reepithelization of human gingival wounds. Another in vitro study suggested taurolidine, a taurine derivative, be used as an antimicrobial in both surgical and non-surgical management of periodontitis. Two animal studies proved taurine to be beneficial in tissue repair in periodontitis. The researchers also noted that in studies of epilepsy patients, the dosage of taurine used ranged from 375 to 8,000 mg/day. One group of patients received taurine 500 mg a day for 15 days followed by placebo once a day for 15 days. The other group of patients received the same regimen but in reverse: they got placebo once a day for 15 days followed by taurine at 500 mg/day for the following 15 days. This study was double blinded. Results: There was a significant reduction in TBARS, a measure of lipid peroxidation, in patients following administration of taurine, consistent with findings in animal studies (cited in the text). Glutathione levels rose while glutathione peroxidase levels declined in gingival tissue and in plasma following taurine administration. The researchers also reported a reduction in probing pocket depth and improved clinical attachment level following taurine administration. To be sure, this is a very small study for a short time period. It would have been nice to have had more data, such as (for example) levels of inflammatory cytokines in the circulation. Nevertheless, it helps point out the po-

tentially broad protective capability of taurine. This is protection that we want and we suspect you want, circulating in your bloodstream! TINNITUS IS PREVENTING ME FROM HEARING THE VOICES IN MY HEAD, JOKES A FRIEND OF OURS TAURINE Even Improved Tinnitus in Rats that Developed Tinnitus As a Result of Exposure to Loud Noise

Tinnitus, the very common condition of hearing noises (buzzing, hissing, snapping, crackling, popping) in the absence of any actual background sound is very difficult to treat and, depending on the individual, can range from merely annoying to very unpleasant to actually disabling. For those plagued by it, there can never be any actual silence. You might wonder how scientists developed an animal model of tinnitus with which to study the effects of potential treatments. After all, the animals can hardly tell you when they are hearing noises (buzzing, hissing, etc.). A 2010 paper18 explains: in humans, loud noise is a tinnitus-inducing stimulus, which can be observed as decreased inhibition (overexcitation) in the auditory pathway. This decreased inhibition in the auditory pathway is also seen in an animal model of tinnitus caused by exposure to loud noise. Taurine is reported to act as an inhibitory neuromodulator by acting at glycine, GABA(A), and GABA(B) receptors, which convey inhibitory neuronal signaling.18 In this way, taurine reduces cellular excitability. Taurine can pass the blood-brain border via a Na+/Cl- dependent taurine transporter.18 One group of animals was exposed to loud noise to induce tinnitus, while another group was unexposed. The animals were tested for hearing threshholds. In the rats exposed to loud noise, the hearing threshhold of the exposed ear was slightly (though not significantly) elevated relative to their unexposed ear. The higher dose of taurine (4 mg/ml in their drinking water) with which tinnitus rats were treated produced a significant therapeutic effect by the ability of these rats to respond to pure tone discrimination functions at levels converging on those of the rats that were not exposed to loud noise. No therapeutic effect was seen at the low dose of taurine (1 mg/ml). After the experiments, when no more taurine was being administered, the rats’ hearing returned to that indicative of tinnitus. Improvements were greater at higher doses of taurine and at higher sound frequencies. The authors note that earlier work of theirs showed that tinnitus did not correlate well with loss of cochlear hair cells. In this study,18 control rats with normal hearing (they were not exposed to loud noise) on a moderately high level of supplemental taurine had improved auditory discrimination performance across a broad frequency range. In fact, taurine improved auditory discrimination in unexposed rats at both the low and high concentrations. CALL 800-543-3873

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On the basis of the amount of water consumed by each rat, the average daily taurine dose was 66.6 ± 20.3 mg/kg/day at the low taurine concentration and 293.6 ± 75.8 mg/kg/day at the high taurine concentration. (The higher dose was roughly equivalent to 1.5 gram of taurine per day for an adult human.) This was a very well done, very convincing study suggesting that taurine may benefit humans suffering from tinnitus. Since tinnitus can be caused by more than one mechanism, benefits may vary. RADIOPROTECTIVE EFFECTS OF TAURINE TAURINE Protection During and After Radiation Exposure—Such as Nuclear Power Accidents

Concern about damage to nuclear reactors in Japan following a large tsunami after a gigantic undersea earthquake was the apparent impetus for looking into protection against radiation exposure, as published in this large review paper.E The researcher considered not only protection against radiation damage but also protection against infections likely to become a problem following

the immune suppression induced by radiation. Taurine can provide protection in both these areas. Considerable data are provided (983 references!). The authors advocate the use of “cocktails” of protective substances as being more likely to provide the desired protection than single substances alone. As they explain it: “[f]or obtaining an optimal therapeutic response, it is probably best in all these cases to use a cocktail of protective substances rather than one substance alone, since there are good theoretical reasons to believe that many of the substances concerned may interact with another in a synergistic fashion—especially when they have completely different biochemical functions or different localization in the cells (e.g., water-soluble versus lipid-soluble antioxidants), or otherwise have completely different mechanisms of action (e.g. free radical scavengers versus redox-active metal ion chelators).”E www.life-enhancement.com

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The authors also complain that available, safe and cheap agents are not more commonly used for the treatment of ubiquitous medical conditions. “It is very strange, when considering how abundant those research data are that show very significant protective effect for some of the substances mentioned here against permanent organ damage caused by ischemia-reperfusion, and how non-toxic and cheap some of them (like taurine, melatonin and glutathione) also are, that the use of these substances has not already become standard routine, e.g. for treatment of stroke patients or patients with myocardial infarction, but also for treatment of other diseases and injuries where permanent organ damage develops as a consequence of ischemia/reperfusion and post injury inflammatory response (e.g. severe head trauma and drowning).” The author also notes that “[t]aurine can undoubtedly help to improve protection of the ‘civilian population’ (both in the case of hypervirulent influenza and radiation sickness), i.e. reduce the risk that the patient will die from a harmful inflammatory over-reaction, because of its antioxidant effect and capacity for scavenging some of these highly reactive antibacterial and antiviral weapons that have low specificity (are imprecisely targeted) and therefore may be especially dangerous to the ‘civilians,’ such as peroxynitrite and hypohalite [hypochlorous and hypobromous acid] ions.” PAIN RELIEVING EFFECTS OF TAURINE ENDORSED BY RATS AND MICE TAURINE’s Antinociceptive (Antipain) Effects May Be Mediated Via GABA(A) and GABA(B) Receptors and Peripheral Cholinergic Mechanisms

The study of pain is complex. As an example, what may relieve one type of pain may not relieve another type. Pinning down the mechanisms responsible for pain relief is also difficult because many different biochemical pathways can be involved. People in severe pain may not be particularly driven by the desire to understand the mechanisms of pain relievers as much as they are to get pain relief any way they can. It is really crucial, though; if you want to find a more effective way to relieve pain you need to understand chemical mechanisms. For one thing, it is often the case that combining different substances will give you a superior effect and/or reduce side effects, as compared to even the best, most powerful single pain killers such as opiates. On the basis of the available evidence, it appears that taurine has antinociceptive (anti-pain) effects, but it is likely to work best in combination with other substances having such effects but working by different mechanisms and, hence, potentially acting together synergistically. 12

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In a recent paper,B determining whether a hot plate test is detecting pain relief or sedation was described this way: “A mouse was placed on a rubber cylinder (height 2.5 cm, diameter 6 cm) after drug or vehicle administration. We recorded the time that elapsed before the mouse jumped off the rubber cylinder. When time taken to step off the rubber was longer than that observed among controls, sedation had been achieved.” This was to determine whether the effect of the treatment on pain had been affected by a sedative effect of the treatment, an effect that had to be considered in evaluating the effect of pain relief on animal behavior. (Did the mouse delay flicking its tail because its pain was reduced or because it was sedated?) “When given alone, intrathecal glycine, taurine, or muscimol had no effect on the pain threshhold index (p>0.05 vs. vehicle controls).” However, when administered with bicuculline, which induces hyperalgesia (high level of pain), glycine, taurine, or muscimol (a cholinergic drug) induced analgesia. The intrathecal administration of muscimol and taurine had more prolonged anti-hyperalgesic effects than did intracisternal administration, as determined by the hot plate test. No sedation was produced by mice injected with glycine, taurine, or muscimol. In conclusion, the researchers found taurine as well as muscimol or glycine to have antinociceptive effects when administered with bicuculline, an agent that induces hyperalgesia in mice. They find that GABA(A) receptor antagonism may represent a possible strategy for treatment of allodynia or hyperalgesia. An earlier paperC had results that suggested that the antinociceptive effects of taurine may be partly mediated by spinal GABA(A) receptors. In a 1992 paper,D researchers studied the effects of taurine administered by injection at about the L5-L6 intervertebral space (intrathecal) on pain in mice in the acetic acid injection-induced abdominal stretch assay, the hot plate and tail flick assays. (The names of these tests sound like something out of The Inquisition … but it’s a study of pain so you can’t avoid inflicting it. In the usual animal studies where painful procedures are involved, scientists are studying something that allows them to anesthetize the animals.) In this study, the researchers found that pretreatment with 12 nmol taurine injected 2 minutes prior to the administration of acetic acid abdominal stretch, expressions of pain were significantly inhibited. But they did not observe pain relief in the tail flick and hot plate assays. Pretreatment with naloxone did not prevent the antinociception (anti-pain effects) seen in the acetic acid abdominal stretch tests, indicating that the taurine anti-pain effect in this test did not involve endogenous opioids.

BROMINE, an Essential Trace Element Is INCLUDED (as bromide) in our new Taurine/Bromine Formulation AT NO EXTRA CHARGE YOU GET BOTH FOR THE SAME LOW PRICE OF TAURINE ALONE A Naturally Formed TAURINE-BROMINE Compound (Taurine bromamine) is Part of the Immune System And is Both Antibacterial and Antiinflammatory

A little known compound, taurine bromamine, produced naturally by the reaction of taurine and hypobromous acid (the latter generated by the enzyme myeloperoxidase), reveals another pathway of taurine activity with important health benefits by enhancing your immune defenses while decreasing inflammation. This is unusual in that increasing immune defenses usually INCREASES inflammation by activating immune system inflammatory cells that attack pathogens. (Taurine chloramine is also produced by taurine reacting with hypochlorous acid resulting from the action of myeloperoxidase, and has similar effects to taurine bromamine.11,12) Myeloperoxidase is recognized as a significant independent risk factor for coronary heart disease, and has been found circulating at elevated levels is patients with confirmed atherosclerosis.13 Hence, the reaction of taurine with oxidant products of myeloperoxidase, such as hypochlorous and hydrobromous acids, to less oxidizing metabolites (taurine chloramine and taurine bromamine) with antiinflammatory and antibacterial properties, is one mechanism of taurine’s protection against heart disease. As one paper19 explained, the reaction of hypochlorous acid and superoxide creates toxic hydroxyl radicals; taurine protects against the creation of these hydroxyl radicals by reacting with hypochlorous acid to convert it to taurine chloramine. A new paper (just arrived in our mailbox)23 provides new information on the myeloperoxidase derived oxidants hypochlorous and hydrobromous acids. The authors explain “… there is strong evidence for MPO [myeloperoxidase] and its associated oxidants in the development of atherosclerosis, together with numerous other inflammatory conditions, neurodegenerative disease, kidney disease, lung disorders, and cancer.” They point to forms of damage that may be relevant to age-associated diseases, such as the reaction of tryptophan residues (tryptophan as incorporated in a protein) with hypochlorous and hypobromous acids that has been shown to contribute to protein unfolding and enzyme inactivation in mechanistic studies, and thus may do the same in vivo. The potentially broad range of damage done by these oxidants is also suggested by evidence they cite of the reactivity of hypobromous acid with the unsaturated bonds of fatty acids and cholesterol. The livers of patients with fibrotic and CALL 800-543-3873

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nonalcoholic fatty liver disease have been found to contain readily detectable myeloperoxidase. Microglia, brain resident immune cells, contain both NADPH oxidase and myeloperoxidase and thus, when activated, can generate hypochlorous acid, potentially contributing to neurodegenerative conditions. The reaction of taurine with hypochlorous and hypobromous acids to form the reaction products taurine chloramine and taurine bromamine is therefore a very important protective mechanism against the collateral damage to tissue that would otherwise occur as a result of myeloperoxidase’s normal physiological activities. Inflammatory Environment Surrounds Cancer Cells May Be Inhibited By Antiinflammatory TAURINE BROMAMINE

Taurine bromamine decreases the production of proinflammatory mediators such as tumor necrosis factor alpha, IL-6, IL-8, PGE2, and others. (A recent paper13B reported that inflammatory environments as found around tumors attract cells called multipotent stromal cells (MSC) that are involved in wound repair and regeneration and that are important in tumor development; the paper mentioned IL-6 and IL-8 as examples of inflammatory cytokines found around tumors, noting that they are highly expressed in breast cancer cells and make significant contributions to the recruitment of these multipotent stromal cells.) Taurine bromamine also reacts with and inactivates hydrogen peroxide and has antiinflammatory properties, such as inducing the synthesis of heme oxygenase-1, a stress-inducible enzyme, and inhibits the activation of NFkappaB, a master regulator of inflammatory gene activation.11 Taurine chloramine, also a natural product derived from taurine reacting with hypochlorous acid generated by myeloperoxidase, increases the activity of heme oxygenase-1 and catalase and also increases intracellular levels of glutathione to protect macrophages in inflamed tissue from oxidative stress.11B Eosinophils are importantly involved in asthma, producing a variety of proinflammatory cytokines that play a major part in the tissue-damaging effects seen in asthma.11C This cell culture study of the effects of taurine bromamine on Jurkat cells reported the inhibition of tumor necrosis factor alpha-induced activation of NFkappaB. As NFkappaB is a master regulator of proinflammatory genes, this evidence supports taurine bromamine’s antiinflammatory effects. The author11 reports on prior research in which he was a contributor showing that topical taurine bromamine was very effective against acne vulgaris, the bane of pimply adolescents, teenagers, and young adults. Six weeks treatment with taurine bromanine in patients with acne resulted in improvement in 90% with a 65% reduction in acne lesions. The same author11 reports that taurine bromamine has a www.life-enhancement.com

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bactericidal activity approaching that of hypochlorous acid (BLEACH is the sodium salt of hypochlorous acid). He reports that taurine bromamine (TauBr) “killed all tested bacteria at non-cytotoxic [no tissue damage] antiinflammatory concentrations.”11 While we mention the use of a topical TauBr cream, remember that TauBr is formed naturally in the body when there is an adequate supply of the essential trace element bromine. But because it may be difficult to get bromine from an ordinary diet, and because bromine is not generally included in multinutrient supplements, you can assure yourself of an adequate daily dose of bromine by taking our taurine/bromamine formulation. Note that this bromine is present in the form of the bromide ion, not as highly toxic and chemically reactive elemental bromine! HISTORICAL NOTE An Early Link between Hypochlorous Acid and Heart Disease

An interesting historical aspect of hypochlorous acid (bleach) are early studies published in a book for public education on the possible unintended consequences of chlorination of water to kill bacteria and other pathogens.A The findings included description of and photos of atherosclerotic lesions produced in the linings of artery walls in chickens given chlorinated (tap) water to drink as compared to chickens given purified water containing no chlorinated compounds. Apparently, this truthful but unwanted revelation of possible adverse effects of chlorinating water upset FDA bureaucrats, who labeled the booklet fraudulent and the physician-author a quack, prohibiting the further distribution of the book via the U.S. mail. The beneficial effects of chlorinating water, which has prevented many millions of cases of waterborne diseases, was without question, but the potential toxicity of chlorinated compounds formed in the process16 should have been treated seriously and, of course, the prohibition of the distribution of the book violated the First Amendment. There was probably concern about public opposition to chlorination of water as well as possible lawsuits alleging that one’s heart disease was caused by chlorination of public water supplies. But the FDA still did not have the authority to prohibit shipment or sale of the book. The U.S. Supreme Court has repeatedly ruled that the public’s reaction to truthful information cannot be used by government to prohibit the dissemination of such information. If the only information that could be disseminated was that which would be analyzed unemotionally by the public, much information would be suppressed. 14

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TAURINE BROMAMINE REDUCES PAIN

Sandy was very pleased to experience a significant reduction in her painful knee osteoarthritis when she began taking an additional supplemental dose of taurine, 1⁄2 tsp twice a day. She estimated her pain was reduced by about 60%. But she was even more delighted by the pain relief—about 75%—that she got after a few days on our taurine plus bromide formulation. It isn’t surprising that the taurine bromamine that results from the chemical reaction of taurine and hypobromous acid (the latter created by the enzyme myeloperoxidase) would help relieve pain due to its powerful antiinflammatory effects. As myeloperoxidase oxidative products are highly inflammatory and released by inflammatory immune cells infiltrating osteoarthritic joints,22 the pain relief is, we think, very likely to be a result of taurine, taurine bromamine, and taurine chloramine. BROMIDE Found in Seawater and in Human Blood

Bromine content (as bromide ion) of seawater (mol/kg) was reported to be 0.000844.14 Bromide has been determined in human blood;15 the overall mean was 5.3 ±1.4 mg/L and varied from 2.5 to 11.7 mg/L. People aged 45–65+ were more likely to have higher bromide levels than younger persons and average bromide levels were higher in females in most age groups. The paper15 also reported that the DAILY INTAKE of bromide from normal (the term “normal” was here undefined) diets is in the range of 0.1 to 0.3 mg Br/kg body weight or approximately (the authors calculate) 8 mg/day for adults. Bromide is reported15 to be mostly excreted via the kidneys. BROMIDE in Drinking Water

According to the World Health Organization (WHO)(2009), “Bromide in Drinking Water. Background document for development of WHO Guidelines for Drinking-water Quality,” concentrations of bromide in fresh water range from trace amounts to about 0.5 mg/l. Dietary Sources of BROMIDE

According to the WHO document mentioned in the paragraph above, the typical daily dietary intake of bromide in the U.S. is 2 – 8 mg from grains, nuts, and fish. In the Netherlands, the WHO document reports the average bromide intake of 8.4 to 9.4 mg/day. Relationship between Sodium Chloride (Salt) and Bromide

Increased consumption of table salt (sodium chloride) increases the excretion of bromide. One possible downside of consuming high levels of salt could be the loss of bromide and, therefore, of taurine bromamine. This was explained by the author in reference #E: The quoted selections below and the immediately following references are by Olav Albert Christophersen:

“Radiation protection following nuclear power accidents: a survey of putative mechanisms involved in the radioprotective actions of taurine during and after radiation exposure” “Bromide is normally much more abundant than Iin the blood, but the Br- concentration of blood plasma is most likely strongly dependent on the average Br/Cl ratio of the diet. During precipitation of NaCl from evaporating seawater, there is a strong fractionation of Br- relative to Cl- because of the larger ionic radius of Br-622 compared to Cl-. This may explain why the Br/Cl ratio of table salt analysed in Finland623 was only 1⁄27 of the Br/Cl ratio found in seawater622.” “In the most common form of allergic asthma,625,628 as well as in other allergic inflammation, eosinophils are major players. In asthma and other allergic diseases, it is therefore the products formed by reaction between taurine and such hypohalite ions that are formed by eosinophil peroxidase that might be most important as anti-inflammatory mediators. Since chloride is of very little importance here, and the production of hypobromite by the eosinophil peroxidase reaction must depend strongly on the bromide concentration in the blood, it may be expected that the reduction of plasma bromide concentrations happening as a consequence of the ingestion of much ordinary table salt may be an important cause of enhanced disease activity (because of reduced production of the inhibitor taurine bromamine) in asthma and other allergic diseases. It may be theoretically expected that a combination of taurine supplementation with normalization of the bromide concentration in blood plasma to the same level as is commonly found in mammals when living in their natural environments might have substantial therapeutic effect by helping to maximize the production of anti-inflammatory taurine bromamine in tissue areas affected by allergic inflammation with eosinophil accumulation and activation.” 622. Krauskopf KB. Introduction to Geochemistry, 2. Ed. Singapore: McGrawHill Book Company; 1982. 623. Koivistoinen P, ed. Mineral Element Composition of Finnish Foods: N, K, Ca, Mg, P, S, Fe, Cu, Mn, Zn, Mo, Co, Ni, Cr, F, Se, Si, Rb, Al, B, Br, Hg, As, Cd, Pb and Ash. Acta Agriculturae Scandi navica. Supplementum 22. Stockholm 1980. 625. Nagata M, Saito K. The roles of cysteinyl leukotrienes in eosinophilic inflammation of asthmatic airways. Int Arch Allergy Immunol 2003; 131(Suppl 1): 7-10. 626. Mori M, Takaku Y, Kobayashi T, Hagiwara K, Kanazawa M, Nagata M. Eosinophil superoxide anion generation induced by adhesion molecules and leukotriene D4. Int Arch Allergy Immunol 2009; 149 (Suppl 1): 31-8. 627. Nakagome K, Nagata M. Pathogenesis of airway inflammation in bronchial asthma. Auris Nasus Larynx. 2011 Feb 18. [Epub ahead of print] 628. Wang W, Hansbro PM, Foster PS, Yang M. An alternate STAT6-independent pathway promotes eosinophil influx into blood during allergic airway inflammation. PLoS One 2011; 6: e17766.

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How to Use the New TAURINE/BROMINE Formulation Each 1⁄2 tsp. Serving Contains 1.5 gram of taurine and 6 mg of bromide

We recommend taking one serving twice a day. (This is the amount we both take.) Our new formulation comes as crystals, which is the least expensive form as it avoids the cost of encapsulation. The product has ABSOLUTELY NO TASTE, so you can mix it in any liquid (dissolves fastest in a warm or hot drink) without worrying about an effect on flavor. Interestingly, if the salt the average American consumes daily were in the form of sea salt, the amount of bromide ingested with that salt would be about 15 mg. The amount of supplemental bromide that we have chosen for our Taurine/Bromine formulation is very small compared to the doses used medically. It is a bit more than the 8–9 mg of bromide contained in a healthy marine food rich diet consumed in the Netherlands. The World Health Organization considers 24 mg bromide to be an acceptable total daily intake for a 60 kg adult, with a safety factor of 10 below the NOEL, No Observable Effect Level. For bromide content of ocean water, see the Handbook of Chemistry and Physics, CRC Press. For further information on safe bromide intake levels, see section … 16. How to Use the New Taurine/Bromine formulation Dietary Sources of BROMINE BROMINE in Drinking Water “Background document for development of WHO Guidelines for Drinking-water Quality” WHO/HSE/WSH/09.01/6 Available here without charge: http://whqlibdoc.who.int/hq/2009/WHO_HSE_WSH_09.01_6_eng.pdf REFERENCES A. Joseph M. Price. Coronaries Cholesterol Chlorine. (1967) (We bought another copy, having lost our original copy, from Amazon.com on June 28, 2014 for $.01 + $3.99 shipping & handling. Unfortunately this wasn’t the first edition, and only the first edition includes the very impressive photographs of the hypochlorite induced atherosclerotic chicken arteries. B. Lee and Lim. Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice. Acta Pharmacol Sin. 31:907-14 (2010). C. Serrano, Serrano, Guerrero, Fernandez. Role of GABA(A) and GABA(B) receptors and peripheral cholinergic mechanisms in the antinociceptive action of taurine. Gen Pharmacol. 25(6):1123-29 (1994). D. Hornfeldt, Smullin, Schamber, et al. Antinociceptive effects of intrathecal taurine and calcium in the mouse. Life Sci. 50:1925-34 (1992). E. Christophersen. Radiation protection following nuclear power accidents: a survey of putative mechanisms involved in the radioprotective actions of taurine during and after radiation exposure. Microb Ecol Health Dis. 23:14787 (2012). 1. Ripps, Shen. Review: Taurine: a ‘very essential’ amino acid. Mol Vis. 18:2673-86 (2012).

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Xu, Ameja, Tappia, et al. The potential health benefits of taurine in cardiovascular disease. Exp Clin Cardiol. 13(2):57-65 (2008) 2A. Schaffer et al. Physiological roles of taurine in heart and muscle. J Biomed Sci. 17(Suppl. 1):52 (2010). 3. Nielsen. How should dietary guidance be given for mineral elements with beneficial actions or suspected of being essential? J Nutr. 126:2377S-2385S (1996). 4. McCall, Cummings, Bhave, et al. Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture. Cell. 157:1380-92 (2014). 5. Hudson et al. Alport’s syndrome, Goodpasture’s syndrome, and type IV collagen. N Engl J Med. 348:2543-56 (2003). 6. Louzada et al. Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer’s disease and other neurological disorders. FASEB J. 18:511-8 (2004). 7. Paula-Lima, De Felice, et al. Activation of GABA(A) receptors by taurine and muscimol blocks the neurotoxicity of beta-amyloid in rat hippocampal and cortical neurons. Neuropharmacology. 49:1140-8 (2005). 8. Chesney, Han, Patters. Taurine and the renal system. J Biomed Sci. 17 Suppl 1:S4. doi: 10.1186/1423-0127-17-S1-S4 (2010). 8B. Wojcik, Koenig, et al. Serum taurine and risk of coronary heart disease: a prospective, nested case-control study. Eur J Nutr. 52(1):169-78 (2013). 8C. Koh, Lee, Hyun, et al. Taurine alleviates the progression of diabetic nephropathy in type 2 diabetic rat model. Int J Endocrinol. 2014:397307. doi: 10.1155/2014/397307 (2014). 8D. Chen, Zhang, et al. Effects of taurine on proliferation and apoptosis of hepatic stellate cells in vitro. Hepatobillary Pancreat Dis Int. 3(1):106-9 (2004). 8E. Das, Ghosh, et al. Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by suppression of cytochrome P450 2E1. Free Radic Res. 44(3):340-55 (2010). 8F. Chang, Chou, Chiu, et al. Preventive effects of taurine on development of hepatic steatosis induced by a high-fat/cholesterol dietary habit. J Agric Food Chem. 59:450-7 (2011). 9. Pizzarelli, Lauretani, Bandinelli, et al. Predictivity of survival according to different equations for estimating renal function in communitydwelling elderly subjects. Nephrol Dial Transplant. 24:1197-205 (2009). 10. Pierno, De Luca, Camerino, et al. Chronic administration of taurine to aged rats improves the electrical and contractual properties of skeletal muscle fibers. J Pharmacol Exp Ther. 286:1183-90 (1998). 10B. Sun et al. Anti-inflammatory mechanism of taurine against ischemic stroke is related to down-regulation of PARP and NF-kappaB. Amino Acids. 42:1735-47 (2012). 10C. Breckwoldt, Chen, Stangenberg, et al. Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase. Proc Natl Acad Sci U S A. 105(47):18584-9 (2008). 10D. Komjati, Mabley, Virag, et al. Poly(ADP-ribose)polymerase inhibition protects neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke. Int J Molec Med. 13:373-82 (2004). 10E. Canto and Auwerx. Interference between PARPs and SIRT1: a novel approach to healthy ageing?” Aging. 3(5):543-7 (2011). 10F. Virag and Szabo. The therapeutic potential of Poly(ADP-ribose)polymerase inhibitors. Pharmacol Rev. 54:375-429 (2002). 10G.Loureiro-dos-Santos, Reis, Kubrusly, et al. Inhibition of choline acetyltransferase by excitatory amino acids as a possible mechanism for cholinergic dysfunction in the central nervous system. J Neurochem. 77:1136-44 (2001).

10H.Tavares, Santos, Stutz, et al. Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-beta peptide oligomers. J Biol Chem. 287(23):19377-85 (2012). 10J. Mikami, et al. Dietary combination of fish oil and taurine decreases fat accumulation and ameliorates blood glucose levels in type 2 diabetic/obese KK-A(Y) Mice. J Food Sci. 77(6):H114-20 (2012). 10K. Franceschi and Campisi. Chronic inflammation (Inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 69(S1):S4-S9 (2014). 11. Marcinkiewicz. Taurine bromamine (TauBr)—its role in immunity and new perspectives for clinical use. J Biomed Sci. 17(Suppl. 1):53 (2010). 11B. Piao, Cha, Kim. Taurine chloramine protects RAW 264.7 macrophages against hydrogen peroxide-induced apoptosis by increasing antioxidants. J Clin Biochem Nutr. 49(1):50-6 (2011). 11C. Tokunaga, Kanayama, Miyamoto. Modification of IkappaBalpha by taurine bromamine inhibits tumor necrosis factor alpha-induced NF-kappaB activation. Inflamm Res. 56:479-86 (2007). 12. Nagl, Hess, Pfaller, et al. Bactericidal activity of micromolar n-chlorotaurine: evidence for its antimicrobial function in the human defense system. Antimicrob Agents Chemother. 44(9): 2507-13 (2000). 13. Skaff, Pattison, Davies. Kinetics of hypobromous acid-mediated oxidation of lipid components and antioxidants. Chem Res Toxicol. 20:1980-8 (2007). 13B. Ilmer, Vykoukal, Boiles, et al. Two sides of the same coin: stem cells in cancer and regenerative medicine. FASEB J. 28:2748-61 (2014). 14. ^DOE (1994). 5” (http://cdiac74/chapter5.pdf). In A.G. Dickson & C. Goyet, Handbook of methods for the analysis of the various parameters of the carbon dioxide system in sea water. 2. ORNL/CDIAC-74. Downloaded 6/25/14 from Wikipedia. 15. Olszowy, Rossiter, Hegarty, et al. Background levels of bromide in human blood. J Anal Toxicol. 22:225-30 (1998). 16. Messner et al. Identification of lysophosphatidylcholine-chlorohydrin in human atherosclerotic lesions. Lipids. 43:243-249 (2008). The authors report finding reactive chlorinating species in human atherosclerotic plaques. Hypochlorous acid is generated by the enzyme myeloperoxidase but also found in chlorinated water. 17. Sree and Sethupathy. Evaluation of the efficacy of taurine as an antioxidant in the management of patients with chronic periodontitis. Dent Res J (Isfahan). 11(2):228-33 (2014). 18. Brozoski et al. The effect of supplemental taurine on tinnitus and auditory discrimination in an animal model. Hear Res. 270(1-2):71-80 (2010). 19. Candeias, Patel, et al. Free hydroxyl radicals are formed on reaction between the neutrophil-derived species superoxide anion and hypochlorous acid. FEBS Lett. 333(1,2):151-3 (1993). 20. Robb, Condron, Moriarty, et al. Taurine attenuates radiation-induced lung fibrosis in C57/B16 fibrosis prone mice. Ir J Med Sci. 179:99-105 (2010). 21. Lim & Kim. The global impact of hepatic fibrosis and end-stage liver disease. Clin Liver Dis. 12:733-46 (2008). 22. Chorazy-Massalska, Kontny, Kornatka, et al. The effect of taurine chloramine on pro-inflammatory cytokine production by peripheral blood mononuclear cells isolated from rheumatoid arthritis and osteoarthritis patients. Clin Exp Rheumatol. 22:692-8 (2004). 23. Rayner, Love, Hawkins. Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells. Free Radic Biol Med. 71:240-55 (2014). 24. Marcinkiewicz et al. Taurine chloramine, a product of activated neutrophils, inhibits in vitro the generation of nitric oxide and other macrophage inflammatory mediators. J Leukoc Biol. 58:667-74 (1995).

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…And They Treasured Cinnamon Maintain your healthy balance of blood sugar and insulin with an extract of Editorial Chinese cinnamon, one of the 50 essential herbs of tradition CONTINUED FROM PAGE

nsulin is one of the most important hormones in our bodies, because it is essential for the production of energy. Made by the pancreas, insulin is released every time we eat, in response to the glucose (blood sugar) that is absorbed from our intestines into our bloodstream. Unfortunately, the typical Western diet ravages the insulin system and causes it to lose functionality through the impairment of blood sugar metabolism. Yet little attention has been given to insulin health. Short of controlling one’s diet and developing a disciplined exercise program—both of which are good ideas not only for supporting run-down blood sugar control function, but also for good health in general—what is a person to do? Supplement your diet with Dr. Jonathan V. Wright’s InsuLife-B,™ an insulin-support nutritional formulation that takes the care and maintenance of your insulin system to a new level.* In this formulation, Dr. Wright has included

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In the last few years, study after study has confirmed berberine to have multiple bioactivities. Among what it can do … • Improves support for Insulin sensitivity • Regulates healthy blood sugar levels already in the normal range • Supports healthy lipid levels • Provides cardiovascular support • Natural berberine from Berberine Oregon grape (Mahonia Grape Power ™ aquifolium) root extract Factory Direct Price • 500 mg berberine/serving $ 97Reg. $39.96 (2 caps) 180 250 mg capsules

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some of the most valuable herbal and vitamin supplements available, including the important water-soluble procyanidins (type A) and MHCP from cinnamon, along with a-lipoic acid, a judicious amount of chromium, the red-wine polyphenol resveratrol, epigallocatechin gallate (EGCG) from green tea, the B-vitamin biotin, and several other nutrients. Dr. Jonathan V. Wright’s InsuLife-B can help: • Enhance energy levels* • Improve insulin sensitivity* • Regulate healthy blood sugar levels already in the normal range* • Enable you to more effectively manage your weight-control program*

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Methylene Blue (MB) A substance with which I’ve recently become aware, which CONT. FROM PAGE 4 has dramatically improved the cognitive abilities of several In 1958, Dr. Leon Oettinger, Jr., reported that DMAE:17 of my patients, is methylene blue. Methylene blue is the first synthetic drug, and has a more than 120-year history of • Accelerated mental processes diverse applications, both in medical treatment and as a • Improved concentration staining reagent. In the pre-antibiotic era, it was used as a • Stopped early morning “fogginess” urinary tract antiseptic. In recent years, it has been used as an antimalarial agent, and as a potential treatment of • Relieved lassitude and mild depression neurodegenerative disorders such as Alzheimer’s disease.22 • Increased attention Methylene blue attenuates the formations of amy• Improved IQ loid plaques and neurofibrillary tangles in the brain Although most of the human studies (characteristic of Alzheimer’s disdone with DMAE were conducted in ease), and partially repairs impairthe 1950s and 60s, more recent animents in mitochondrial function and mal studies appear to confirm these cellular metabolism.23 For this rea18,19 early reports. Additional benefits son, it may also help with cerebral of DMAE include its ability to prevent insufficiency. Methylene Blue also inand reduce the accumulation of lipohibits acetylcholinesterase (AChE) fuscin (which causes “aging spots”) in and butyrylcholinesterase (BuChE), the skin, heart, muscles, kidneys, which favorably affect the neuronerves and brain,20 and to extend the transmitter system believed to be inmean and maximum lifespan of exvolved in Alzheimer’s.24 perimental animals (Fig. 1).21 Methylene blue is inexpensive and I recommend 500 mg DMAE be Figure 1. Life-extending effects of DMAE in available by prescription from some A/J mice. (Hochshcild, 1973). taken each morning. compounding pharmacies. I prescribe

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Introducing Durk & Sandy’s “ESSENTIALS” line, with …

Taurine ’n More W

hen designing your Life Extension Program you should not go without very low-cost high-benefit taurine, nor should you miss out on the essential trace mineral bromine (as bromide). Out of these, your body can manufacture a natural taurine-bromine compound, an amazing nutritional vehicle for greater health. Taurine bromamine helps protect you from [CENSORED BY THE FDA]. Of course, even the FDA can’t prevent YOU from searching the National Library of Medicine at https://ncbi.nlm.nih.gov/pmc/?term=taurine+bromamine and https://ncbi.nlm.nih.gov/pubmed/?term=taurine+bromamine There are a very large number of dietary supplements on the market, but since nobody can (or should) try to take everything, each of us is presented with the difficult problem of picking and choosing the supplements that fit within your budget AND represent the most important elements to include in your personal program to help increase your healthy lifespan. We hope to make this a little bit easier by identifying specific supplements—that we call ESSENTIALS— for their exceptional importance in a program (including ours) for health and long life. These are basic supplements for any well-designed health program and, as you will see, you don’t have to spend a lot for the ESSENTIALS. The amino acid TAURINE is one of our ESSENTIALS, and represents a great value: for a low price, you get a nutrient that provides a dazzling array of health benefits throughout your body and brain. Plus, we include BROMINE (in the form of bromide), long suspected of being an Taurine ’n More™ essential trace element and now definitely shown to be essential, as it is required for Factory Direct Price proper assembly of collagen IV scaffolds crucial for organogenesis (development of organs). Furthermore, bromine sufficiency may help alleviate basement membrane Reg. $8.50 deterioration, which is detrimental to nutritional and lung wellbeing. And much, much Three Month’s supply more! Try it—you'll love it. Absolutely tasteless. Use 1/2 teaspoon (1.5 g taurine, 6 mg 271 g/btl (1.5 g/serv) bromide), twice daily. Stir into water or a beverage of your choice. To your health!

595

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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You too can develop the Midas touch and add to your health ledgers with …

The Wealth of Berberine Berberine Research Continues to Unfold

Will Block

of berberine were complex, which involved multiple cellular kinases and signaling pathways.

f personal wealth included health—which it arguably should—one of the top coins of your wellbeing might be berberine, an herbal extract which imparts a golden color. In fact, berberine showed up in the first millennium in China as a preservative of valuable ancient idea-preserving manuscripts, which are imbued with the color of berberine (see “Take This Dye for Diabetes” in the November 2010 issue). Also historically intriguing, the plague devastated Asia and Europe in the second millennium without much medicinal defense, although evidence exists showing that berberine-containing barberry fruit was used by ancient Egyptian pharaohs and queens to ward off the plague.1 Recent berberine research has found berberine use as a therapeutic agent of choice against the plague versus conventional antibiotics.2 Imagine how history would have been changed had the Egyptians shared their knowledge. Berberine for Diabetes

In the last few years, study after study has confirmed berberine to have multiple bioactivities, including cholesterol-lowering, antiinsulin resistance, anti-diabetes, cardiovascular protection, anti-inflammation, and anti-cancer properties. In a recent review, researchers summarized the antioxidant and anti-inflammatory activities of berberine as well as their molecular basis.3 These beneficial activities changed oxidative stress markers, antioxidant enzymes, and proinflammatory cytokines after berberine administration in diabetic animals. Berberine was found to inhibit oxidative stress and inflammation in various tissues including kidney, liver, adipose tissue, and pancreas. Mechanisms of the antioxidant and anti-inflammatory activities Will Block is the publisher and editorial director of Life Enhancement magazine. CALL 800-543-3873

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Berberine for Cancer

We know that breast cancer is the most common cancer among women worldwide, and while conventional medicine has been useful, it has not demonstrated the needed efficacy. So novel therapeutic agents such as berberine are promising. In a recent review, the molecular targets of berberine in breast cancer, among other cancers are discussed.4 Berberine has been found to be effective in inhibiting cell proliferation and promoting apoptosis in various cancerous cells. Pathways affected by berberine, include the MAP (mitogen-activated protein) kinase and Wnt/b-catenin pathways (Wnt signaling was first identified for its role in carcinogenesis). These have been determined as critical for reducing cellular migration and sensitivity to various growth factors. AS well, there are recent promising studies based on microRNAs and other crucial regulators that help define the action of berberine in cancer. Berberine for Memory

And that’s not all! Recent studies have found that berberine can fight dementia and Alzheimer’s disease along with improving memory. Berberine has been found to possess multiple memory pharmacological effects: it can inhibit acetylcholinesterase (which breaks down the important memory molecule associated with concentration and focus), and induce improved survival, development, and function of neurons, while protecting these electrically excitable brain cells (see “Berberine is Very Promising for Alzheimer’s” in the February 2012 issue). Furthermore, in the references papers, berberine was found to reduce the production of amyloid-beta 40–42 plaque, which plays a primary and critical role in the neurological degradation that bottoms out in Alzheimer’s disease. www.life-enhancement.com

SEPTEMBER 2014

Berberine Fights Tau and Neurofibrillary Tangles

Even more recent research has found that berberine protects against neuronal cell death induced by homocysteic acid, which is considered as a risk for Alzheimer’s.5 Another recent study has found that berberine can protect the brain cells from induced toxicity in metabolism and viability, as well as hyperphosphorylation of tau and neurofilaments, hallmarks of Alzheimer’s.6 Berberine modulated the activity of crucial phosphatases that dampen phosphorylation as well as oxidative stress, and reversed hyperphosphorylation of tau and neurofilaments, the axonal transport impairment induced in a cell line used to study cells have been used to study neurotoxicity and Alzheimer’s disease. In mice, berberine improved short-term memory by inhibiting apoptosis in the hippocampus, thus demonstrating that it may serve to alleviate memory impairment and motor dysfunction in patients with PD.7 Berberine Research Continues to Unfold

For vision: New findings suggest that leukocytes from diabetes kill retinal endothelial cells, and that berberine inhibits this process and thus represents a therapy against diabetic retinopathy.8 For polycystic ovary syndrome: Another new study postulates that women with PCOS will have improved insulin resistance following berberine administration. For oral mucosal disease: Recurrent aphthous stomatitis is a common oral mucosal disease, yet effective therapeutic approaches are lacking. In a randomized, doubleblind, placebo-controlled, clinical trial, berberine was given to 84 Chinese subjects, without obvious side effects.9 Berberine reduced the ulcer pain score compared with placebo and ulcer size was significantly reduced.

The Door into Summer CONTINUED FROM PAGE

of new scientific nutritional discoveries. Many of these are ably and amply described and referenced in the pages of this publication and with increasing speed for good measure. With what will surely be known as the great explosion (of ideas and applications) we endeavor to take greater advantage of the findings and as early adapters continue to grow healthier and healthier. Take for example the principal article in this issue about a natural taurine-bromine compound that shows how it is possible make major inroads to significantly control inflammation and microbial activity. As 20

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SEPTEMBER 2014

Also, lower erythema and exudation levels were associated with berberine treatment. Berberine Is a Good Choice

I could go on (and Life Enhancement will), but berberine continues to looks better and better as an important aspect of your supplement program. Add to your wealth and your health with berberine. g REFERENCES 1. Chevallier A: The Encyclopedia of Medicinal Plants. St Leonards: Dorling Kindersley; 2001. 2. Zhang J, Zuo G, Bai Q, Wang Y, Yang R, Qiu J. Microarray expression profiling of Yersinia pestis in response to berberine. Planta Med. 2009 Mar;75(4):396-8. 3. Li Z, Geng YN, Jiang JD, et al. Antioxidant and anti-inflammatory activities of berberine in the treatment of diabetes mellitus. Evid Based Complement Alternat Med. 2014;2014:289264. doi: 10.1155/2014/289264. Epub 2014 Feb 11. 4. Jabbarzadeh Kaboli P, Rahmat A, Ismail P, et al. Targets and mechanisms of berberine, a natural drug with potential to treat cancer with special focus on breast cancer. Eur J Pharmacol. 2014 Jun 26. pii: S00142999(14)00467-1. doi:10.1016/j.ejphar.2014.06.025. [Epub ahead of print] 5. Chen M, Tan M, Jing M, et al. Berberine protects homocysteic acid-induced HT-22 cell death: involvement of Akt pathway. Metab Brain Dis. 2014 Jul 23. [Epub ahead of print] 6. Liu X, Zhou J, Abid MD, et al. Berberine attenuates axonal transport impairment and axonopathy induced by Calyculin A in N2a cells. PLoS One. 2014 Apr 8;9(4):e93974. doi: 10.1371/journal.pone.0093974. eCollection 2014. 7. Kim M, Cho KH, Shin MS, et al. Berberine prevents nigrostriatal dopaminergic neuronal loss and suppresses hippocampal apoptosis in mice with Parkinson’s disease. Int J Mol Med. 2014 Apr;33(4):870-8. 8. Tian P, Ge H, Liu H, et al. Leukocytes from diabetic patients kill retinal endothelial cells: effects of berberine. Mol Vis. 2013 Oct 2;19:2092-105. 9. Jiang XW, Zhang Y, Zhu YL, et al. Effects of berberine gelatin on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial in a Chinese cohort. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Feb;115(2):212-7.

You’ll find this article and further relevant information on the Internet at www.life-enhancement.com.

examples of what else it can do, let us say alleviate osteoarthritis, protect against kidney malfunction, liver damage, liver fibrosis and fatty liver. Not to mention lessening cardiovascular disease, cardiac arrhythmias, ischemic stroke, periodontitis, tinnitus, pain, and more. Remember as we approach Fall that what have been for many the ultimate preclusions of life needn’t be our endings. They can be our glad good news and new beginnings, and open the door of Summer ever more widely. Live long and prosper,

Will Block PS: Don’t forget Greater Rewards! It is possible to be happier, and that too will prolong our summers.

Who Is Will Block?

A Human Perspective on a Visionary Mind Dr. Joyce Block Chief among the principal operative or instrumental means to happiness, although not secondary to moral virtue and prudence, is … FREEDOM. Sometimes it’s called internal freedom, and sometimes it’s called moral freedom. It is the freedom possessed by the virtuous man who is able, by habitual disposition, to will as he ought. Stated negatively, it is the freedom from the opposing pressure of immediate wants, which enables man to seek what he wants in the long run. — Will Block, 1971 Stage One: Preparation 1970’s—The Pantry

Will, the computer “shrink” walked into the house. I had just come back from the Princeton Brain Bio Center and was in the pantry shooting up with Vitamin B12. It was but a part of my regimen to combat the doctoral student pressure cooker. Will popped his head in. “How do you know that will work?” I mentioned Dr. Carl Pfeiffer’s book on orthomolecular biochemistry balancing. “This is a biomedical approach to psychiatry. I’m not crazy. My synapses are misfiring. Pfeiffer’s book is on the kitchen counter.” I wanted Will to approve, but I knew he would question every word, every study, and every conclusion. On the other hand this was the very thing that made him a riveting conversationalist. He knew volumes about any subject from philosophy and political science, to the classics, to computers, to music, art, and even wine. Yet he was a pro at jacking blue crabs and spearing eels in salty inlets where the Atlantic Ocean spilled into the bays. As a student of the world living in NYC’s Chelsea, Will created his own curriculum. He finished each solo day off with a 5 star home-cooked plate accompanied by the finest wines. The music of Mahler, Wagner, CALL 800-543-3873

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Bach, and Delius among others, were his dinner partners, along with a well-chosen book. Although his best skills didn’t include psychosocial savvy, I didn’t mind. I would listen to him because he would make my mouth drop by the breadth and depth of his knowledge. This was far better than the lecture halls. It was better than being at the main New York Library, because he could soliloquize in every direction. As deftly as I could, I would slip in a question, “So how can I apply these great ideas to my life so I can make a difference in the world?” As a person brought up in a loving, value-driven family, I set my course on breaking rank with the small town cultural desert that surrounded me. I was growing in graduate school, but mostly from my “chosen” teachers, of which Will was one. I invited Will to be my outside professor. These interchanges proved to be a great fit in terms of my doctoral dissertation on Collaborative Learning Relationships. I invited him to examine his world from a human development perspective, including the psychosocial, physical, and cultural viewpoints. More importantly, we would examine his life as a creative mind in search of a mission. Look at This! Look at That!

Will grew up in Newark, NJ with a Mensa mother, an athlete father, and a brilliant older brother. His mother described Will as a child who excitedly pointed his finger at the most ordinary and extraordinary things, saying, “Look at this! Look at that! It was hard to move in a straight line because he stopped to see everything!” While Will attended Carnegie-Mellon where he was an honor student along with his brother, he left in his senior year to explore the cultural paradigm shift shaking the Earth in San Francisco—far more interesting than the dry and unavoidable aspects of prescribed academia. While his brother remains a world-recognized probability mathematician, Will’s future as a computer engineer paled compared to his drive to seek out and explore the many new worlds that were springing into awareness. Will introduced me to his teachers, including Aristotle, www.life-enhancement.com

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Ayn Rand, Ludwig von Mises, Robert G. Ingersoll, Arthur Koestler, Robert Anton Wilson, and a couple of scientists promoting an integrated world view, Durk Pearson and Sandy Shaw, altogether spanning the golden arc of freethought. The perspectives I soaked up thrust me out of the limits of depending on psychosocial constructs to make sense of my world. I finally understood the dynamic tension between thinking and feeling through the thought of Ayn Rand that, “Emotions are not tools of cognition.” I realized that the dynamic tension between thinking and feeling were, indeed, the very underpinnings of the creative process and needed to be harnessed into creative work. Stage Two: Frustration 1980’s—Lights go out. Lights go on.

In 1982, Ayn Rand died. In 1983 Arthur Koestler left this world by his own hand. Life was finite. By 1983 Pearson and Shaw were deep into life extension research and had published their 1.5-million copy best seller, Life Extension: A Practical Scientific Approach a year earlier. In 1983 Will’s first child, Bherin, was born. By now, Will had taken to the pantry as well. Longevity mattered. In any creative process there are predictable stages a person travels through: Preparation, Frustration, Incubation, Illumination, Elaboration and Validation. Without conscious explicitness, Will had been preparing for a life of integrity and meaning much of his early adult years. His appetite and aptitude to master and integrate vast amounts of information was apparent. He could do anything, but how would that “anything” manifest in the world? Frustration is marked by a period of knowing what’s important but not knowing how, or, if it will come to fruition. It is a period of rich learning replete with false starts, blind alleys, and lost alliances. It tests the creator’s will to go on even when he does know exactly where he’s going. Some others watching a person in this period may want to blurt out, “So what do you want to be when you grow up?” Too bad for them! It’s a period only the brave may enter. It is a period when you realize that you are the maker and sculptor of your life. To quote Rand, “Man is a being of self-made soul [consciousness]— and it is of such conclusions that the stuff of his soul is made.”* * Rand, A. The Romantic Manifesto: A Philosophy of Literature. Rev ed. New York: Signet, 1975. 22

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Stage Three: Incubation Company in the Pantry

Unfulfilled in his career as a high level 24–7 computer consultant, Will turned his focus toward more creative and challenging work as a videographer. Alongside this avocation lived the researcher in search of lifeextending technologies. Sparked by Pearson and Shaw’s wildly successful book, Will traveled to California to meet the two of them in their Manhattan Beach libraries and laboratories to discuss a documentary about them, their ideas, and their newly created nutritional supplements. With relish, in the first meeting he realized what a great opportunity this represented despite how much he had to learn to transform his knowledge into work. Whoopee! Plus, he might have a chance to live a very long time. As a new father, the less structured time perks were favorable and the time to explore new disciplines was proving highly attractive. During this period Will produced documentaries under the banner of his company TVSee on such diverse subjects as the war in Eritrea, child development, the Armenian Holocaust, cooking, infertility, somatic healing techniques, and futurism. He also interviewed a number of influential writer-thinkers, heroes in their own right. Yet the challenges of running an undercapitalized business presented a steep learning curve. Nevertheless, Will’s talent for the medium and persistence to produce a superior product was proof that he was not a dilettante but closer to a Renaissance man. For me, it was exhilarating to be a co-creator in these highly challenging endeavors. Sometimes his toddler daughter accompanied him on video shoots by sitting on his shoulders with her hands wrapped around his neck. Other times he was exercising or in his studio editing a video, or writing. At some point he would slip into the kitchen to replenish himself by cooking cuisine par excellence, replete with the right wine, while music wafted through the rooms. Three times a day, he too visited the pantry organizing his nutritional supplements just so. The discipline of finding and taking supplements was now an ingrained practice. No doubt it was a rich time for learning. But a piece of Will‘s livelihood was stuck in a not-for-profit world. Unless you are part of the government (never!) and buy into that model, things can only go one way. For real change to ensue, Will realized he needed to operate in an entrepreneurial venue. This pursuit would hurl him into a greater world of opportunity, yet it carried higher risk without any guarantees. He needed to step back into what he knew in the computer world: the ability to move quickly and the commitment to live in the 24/7 cycle without getting needlessly caught in the trap of bureaucratic passivity. It would be a big leap. Rob Asghar explained this well in Forbes, … “a nonprofit is like living in a small town.

Working for a for-profit corporation is like living in a large city.” It was time to move to the “city.”† Will’s vision widened one more time. Now, he knew the goal: a commercial venue, where accumulated skills, avocation passion, and biomedical knowledge could meet. Stage Four: Illumination 1986: The “Ah Ha!” Moment

Then it happened. After a viewing of one of Will’s documentaries by his lawyer, Will became engaged to produce an infomercial about the ideas and work of Durk Pearson and Sandy Shaw. It was the perfect medium for the next step. In retrospect, this was Will’s “Ah, Ha” moment. The videographer and the biomedical researcher tied the knot. What followed was the development of a Pearson/Shaw line of products, a newsletter, a staff, and some partners. His mission to bring his passion for cutting-edge research, life-prolonging nutrients, and highlevel information to the marketplace was coming to fruition. Will was in business. Stage Five: Elaboration 1986–1993: 99% Perspiration, Ethical Dilemmas, Hard Lessons

The elaboration stage gives a creative product its quality and its longevity. It is the stage about which Thomas Edison said, “Genius is one percent inspiration and ninetynine percent perspiration.” This is when you are doing the hard work of testing, pruning, adjusting course, and safeguarding your “baby.” Will, as a person of high integrity found it hard to compromise his values. He held his business to the same standards he applied to his heroes, his music, and even cooking expertise. Sometimes he would invite his daughters to be assistant chefs, but the assistance had to be to his standard, teaching them the value of doing something well. When it came to cutting corners, or sacrificing the purity of product ingredients, Will would hold his ground! For him to accept an alternative, you had to convince him that it was in the service of the ideas and the product. After working with partners, teams, and committees, Will came back to the table and decided it was better to have dinner alone. He didn’t want his standards compromised, his innovative mind hampered. If he had to go out and “catch” the ingredients, he knew how to do it. If he had to endure the difficulty of going it alone in the dark, he would do it. If he had to spend more money making the finest and most nutritionally potent formulas, he would do it. Asgar R. Should You Work For A Nonprofit Or A For-Profit: Comparing A Small-Town And Big City Mentality. http://www.forbes.com/sites/robasghar/2013/10/22/small-townor-big-city-do-you-have-a-nonprofit-or-for-profit-mindset/. Published October 22, 2013. Accessed July 22, 2014. †

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With or without partners, Will believed he would find a way to pay the bills, but would never skimp. Although it’s called integrity on an ethical level, I call it good business sense, the stuff that pays off in the long run. In business, the bottom line is king, and if Will has an Achilles heel, it’s his trust that others believe in the same unwavering principles that he does. Insistence on top grade ingredients, the highest standards of production, and the delivery with truthful and non-misleading information are Will’s bottom line. It takes business partners who are equally impeccable to make innovative practical products. This is Pearson and Shaw’s recent take on Will in 2014: “… [W]e can always TRUST Will to deal with us honestly and honorably, something that is so remarkably rare. You add that to a sunny personality and a brilliant, creative mind and you have the basis for a lifelong bond.” — Email communication, June 2014 Reclaiming the Mission

The period before Will went “solo” is why I don’t read fiction. You could never make this stuff up. Will’s Elaboration stage is a story akin to Homer’s Odyssey, a ten-year period of the hero’s adventures full of intrigue, and moments of seduction. Long before Odysseus returns home (perhaps 1–2 years into his Odyssey) on the island home of Circe about half of his men are drugged with an anticholinergic substance that makes them forget their mission, along with the homeland, their wife and their families. Thus, the possibility they could ever return is all but destroyed. Not drugged, Odysseus serves up an herbal antidote, which became the principal ingredient of GalantaMind. To quote from one of Will’s articles, “To break the spell on his men and restore their memory, Odysseus used a potion of his own, made from a flower that Homer called Moly; it was a gift to Odysseus from Hermes, the messenger of the gods.” (Life Enhancement, August 2004.) The gift of Moly ultimately rescues his crewmembers from the sleep of forgetfulness. With this, they could return home. For Will, coming out of the chaos of this stage was almost like waking from a dream. Like all harrowing experiences, Will came out of this period recognizing the depth of his strength, the verity of his mission, and the enduring support from those who believed in his work. Life Enhancement, Will’s new company, was incorporated in 1994. Will sat securely in his CEO observation post and guarded his “baby” even closer. He had won the psychosocial savvy skills, which translated into taking charge of the whole enterprise. Will’s second daughter was born and the company moved to California. The accomplishments that ensued, as Life Enhancement was back in the hands of its native father, proved that Will’s adherence to his principles was paying off. In spite of the arduous journey, the company broke into international markets, and the newsletter format became a magazine. www.life-enhancement.com

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Will was invited to prestigious speaking engagements, as Life Enhancement attracted well-known clinics, doctors, authors, and formulators. His stature was growing. Pearson and Shaw moved to the noteworthy place of being proclaimed as the “Founders of the Anti-Aging Movement,” as declared by the spokespeople of the American Academy of AntiAging Medicine, at their 2007 Conference in Las Vegas. California, for all its perks, was not the ideal business climate for Life Enhancement. Will left his revered Frank Lloyd Wright abode and bought a state-of-the art building in Minden, NV. As a testament to Life Enhancement’s ability to create loyalty, key members of the staff moved over 200 miles to continue working for Will. The Manifestation of Innovation

Over the years friends and colleagues spoke openly and appreciatively to Will about the breadth and depth of his mind. But for Will, being talented and smart wasn’t enough. Once when someone asked him, “So who is the person you compare yourself to judge your success?” He named Johannes Brahms, a composer to whom success he Emord & Associates’ 20th Anniversary Celebration Awards Committee has selected Will Block to accept the firm’s “Excellence in Health Product Innovation Award ” honoring Life Enhancement’s product formulations that have improved the quality of life and public health. It will be presented in September at the firm’s 20th Anniversary Gala (entitled “Sacred Fire of Liberty”). Digital photos of the awards ceremony will be issued with a press release immediately after the event. Media will also be present. Attendees will include members of Congress; executives in the food, dietary supplement, and over-the-counter drug industries; scientists and integrative medicine practitioners from around the world; prominent D.C. area constitutional and administrative lawyers; public policy leaders from across the nation; and prominent journalists in the health and general media.

About Jonathan Emord, President and Principal, Emord Associates

Celebrated FDA Lawyer Jonathan Emord, President, Principal of Emord & Associates, has defeated the Food and Drug Administration more times in federal court than any other attorney in American history. His firm represents over 450 different food, dietary supplement, over the counter and compounded drug, medical device, and biologics companies on issues of regulatory compliance, claims and advertising, and agency investigations and enforcement. 24

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Life Enhancement’s new building in Minden

came late in life. Over the years Will has begun to appreciate his visionary mind and talent to create something real. The tide has turned over these last decades and this is how Will writes about himself today: “Will Block is a researcher, writer, and speaker specializing in the life extension, life enhancement, and cognitive enhancement aspects of nutritional science. His writings have appeared widely in newsletters, magazines, and books. He is also the author of Tools for Privacy, a book about public-key encryption and speaks about futurology, nootropics, nanotechnology, and freedom. Innovation is our Lifeblood

“Life Enhancement was the first company to market non-prescription DHEA, making it commercially available in the summer of 1995. We were also first to market pregnenolone, 5-HTP, vinpocetine, mastic gum, the world’s first DNA support supplement, galantamine, and many more firsts. We’ve been out there pushing the envelope and building acceptance for the enhancement of life since 1985, when the concept of life extension supplementation first gelled.” Stage Six: Validation 2014: Recognition in High Places–The Award

The validation stage in the creative process is something like a parent sending the baby that has been doted on and struggled with out into the world. It’s the applause at the end of the performance from those you respect the most. Excellence in Health Product Innovation Award

Apparently someone out there noticed. Will Block and Life Enhancement are to be given an award this September in Washington by Emord & Associates, a prestigious Washington FDA Law Firm (see sidebar). Something of consequence has come to life…

…because of Will. Call it persistence, courage, or brilliance of mind, his visionary innovations will never cease to be. g

Ask Life Enhancement

CONT. FROM PAGE

doses of 50 mg per day. Patients need to be warned in advance that it will turn their urine a striking, almost phosphorescent blue color. The only other side effect that has been reported to me is that patients’ memories improve and they begin to act “normal.” Although each of these nutrients tends to be beneficial when used separately, I’ve found that they generally are synergistic—i.e., they complement each other. Other substances that might be beneficial for your husband include Durk & Sandy’s high-potency EPA/DHA-containing Omega-3 formulas (for their antiinflammatory, anti-coagulant effects), and their lowglycemic food formulas (to help with weight loss). Please let me know how he does, Ward Dean, MD REFERENCES 1. Balestreri R, Fontana L, Astengo F. A double-blind placebo controlled evaluation of the safety and efficacy of vinpocetine in the treatment of patients with chronic vascular senile cerebral dysfunction. J Am Geriatr Soc. 1987;35:425-30. 2. Santos MS, Duarte AI, Moreira PI, Oliveira CR. Synaptosomal response to oxidative stress: effect of vinpocetine. Free Radic Res. 2000;32:57-66. 3. Feigin VL, Doronin BM, Popova TF, Gribatcheva EV, Tchervov DV. Vinpocetine treatment in acute ischaemic stroke: a pilot single-blind randomized clinical trial. Eur J Neurol. 2001; 8:81-5. 4. Patyar S, Prakash A, Modi M, Medhi B. Role of Vinpocetine in cerebrovascular diseases. Pharmacologic Reports. 2011;63(3):618-28. 5. Rosadini G, Marenco S, Nobili F, Novellone G, Rodriguez G. Acute effects of acetyl-L-carnitine on regional cerebral blood flow in patients with brain ischaemia. Int J Clin Pharmacol Res. 1990;10(1-2):123-8. 6. Arrigo A, Casale R, Buonocore M, Ciano C. Effects of acetyl-L-carnitine on reaction times in patients with cerebrovascular insufficiency. Int J Clin Pharmacol Res. 1990;10(1-2):133-7. 7. Postiglione A, Cicerano U, Soricelli A, De Chiara S, Gallotta G, Salvatore M, Mancini M.Cerebral blood flow in patients with chronic cerebrovascular disease: effect of acetyl L-carnitine. Int J Clin Pharmacol Res. 1990;10(1-2):129-32.

8. Postiglione A, Soricelli A, Cicerano U, Mansi L, De Chiara S, Gallotta G, Schettini G, Salvatore M. Effect of acute administration of L-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct. Pharmacol Res. 1991 Apr;23(3):241-6. 9. Lino A, Boccia MM, Rusconi AC, Bellomonte L, Cocuroccia B. [Psycho-functional changes in attention and learning under the action of L-acetylcarnitine in 17 young subjects. A pilot study of its use in mental deterioration]. Clin Ter. 1992 Jun;140(6):569-73. 10. Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int Clin Psychopharmacol. 2003 Mar;18(2):61-71. 11. Kleijnen J, Knipschild P. Ginkgo biloba for cerebral insufficiency. Br J Clin Pharmacol. Oct 1992; 34(4):352–8. 12. Grässel E. [Effect of Ginkgo-biloba extract on mental performance. Doubleblind study using computerized measurement conditions in patients with cerebral insufficiency]. [Article in German] Fortschr Med. 1992 Feb 20;110(5):73-6. 13. Oskouei DS, Rikhtegar R, Hashemilar M, et al. The effect of Ginkgo biloba on functional outcome of patients with acute ischemic stroke: a doubleblind, placebo-controlled, randomized clinical trial. J Stroke Cerebrovasc Dis. 2013 Nov;22(8):e557-63. doi: 10.1016/j.jstrokecerebrovasdis.2013.06.010. Epub 2013 Jul 18. 14. Odinak MM, Kashin AV, Ememlin AIu, Lupanov IA. [Therapeutic correction of mild cognitive impairment in patients with chronic cerebral ischemia]. [Article in Russian] Zh Nevrol Psikhiatr Im S S Korsakova. 2013. 15. Haubrich DR, Gerber NH, Pflueger AB. DEANOL affects choline metabolism in peripheral tissues of mice. Neuropsychopharmacol. J Neurochem. 1981;37:476-82. 16. Millington WR, McCall AL, Wurtman RJ. DEANOL acetamidobenzoate inhibits the blood brain barrier transport of choline. Ann Neurol. 1978;4:302-6. 17. Oettinger L. The use of Deanol in the treatment of disorders of behavior in children. J Pediat. 1958;53:761-5. 18. Levin ED, Rose JE, Abood L. Effects of nicontinic dimethylaminoethyl esters on working memory performance of rats in the radial-arm maze. Pharmacol Biochem Behav. 1995 Jun-Jul:51(2-3):369-73. 19. Malanga G1, Aguiar MB, Martinez HD, Puntarulo S. New insights on dimethylaminoethanol (DMAE) features as a free radical scavenger. Drug Metab Lett. 2012 Mar;6(1):54-9. 20. Zs-Nagy I, Floyd RA. Electron spin resonance spectroscopic demonstration of the hydroxyl free radical scavenger properties of dimetheylaminoethaol in spin trapping experiments confirming the molecular basis for the biological effects of Centrophenoxine. Arch Gerontol Geriatr. 1984 Dec:3(4):297-310. 21. Hochschild R. Effect of dimethylaminoethanol on the life span of senile male A/J mice. Exp Gerontol. 1973;8(4):185-91. 22. Schirmer RH, Adler H, Pickhardt M, Mandelkow E. Lest we forget you— methylene blue … . Neurobiol Aging. 2011 Dec;32(12):2325.e7-16. doi: 10.1016/j.neurobiolaging.2010.12.012. Epub 2011 Feb 12. 23. Oz M, Lorke DE, Petroianu GA. Methylene Blue and Alzheimer’s Disease. Biochem Pharmacol. 2009 Oct 15; 78(8):927-32. 24. Petzer A, Harvey, BH, Petzer JP. The interactions of azure B, a metabolite of methylene blue, with acetylcholinesterase and butyrylcholinesterase. Toxicol Appl Pharmacol. 2014 Feb 1;274(3):488-93.

From Durk Pearson & Sandy Shaw® . . . Turmeric Root Power™

Get All the Curcuminoids and more from WHOLE TURMERIC capsules L

ooking for the best way to get higher levels of curcumin and other curcuminoids? Did you know that there are additional bioactive compounds in whole turmeric, other than the curcuminoids, many of which are as potent as curcumin? It’s been reported that curcumin has low bioavailability, and that may be true. However, it is interesting to note that one formulation, claiming the high-

est curcumin bioavailability, first extracts curcumin from whole turmeric leaving the natural essential oils behind, and then mixes the oils back in! When you cut a piece of fresh turmeric, you will notice that your hands turn yellow, an indication that there is good bioavailability, because skin has evolved to be highly resistant to penetration by foreign substances. Also, if you’re taking whole turmeric, your stool does not turn yellow. More proof!

To add higher levels of curcumin and all the bioactive ingredients to their supplement program, life extension scientists Durk Pearson & Sandy Shaw take whole ground turmeric, and now you can do the same. Each easy to take, flavor-free capsule of Turmeric Root Power contains 600 mg of ground turmeric, for a recommended serving of 2 capsules, 3 to 4 times daily.

• Powerful antioxidant* • Stress management support* • Helps maintain cardiovascular health and liver function* • Supports healthy joints* • Brain support*

What more do you need to know? Act today! • Supports healthy inflammatory-response function*

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. CALL 800-543-3873

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SEPTEMBER 2014

Essential Cocktails....

Here’s to Your Health! — Dr. Joyce Block

See this month’s article on page 4

Across 1.

6. 7.

10.

11.

12. 14.

15.

It is important to know that even a single daily _____ drink taken in conjunction with regular use of acetaminophen increases the risk of liver injury. Clue: Smoking hot information flash. Look for the answer in the first third of the article. The quote is in all caps. The authors advocate the use of “cocktails” of protective substances as being more likely to provide the desired _____ than single substances alone. Clue: Shield. In the list of the 16 topics in this article, one is designed to make you smile. Whch one? Clue: A numeral expressed as a word. We have Identified specific supplements— that we call _____ for their exceptional importance in a program (including ours) for health and long life.Clue: Absolutely necessary (pl). What condition would help prevent you from hearing the voices in your head, and the voices of those you don’t want to hear at all. Clue: Investigate the words in caps in the middle of the article. Researchers, Das, Ghosh, et al. conclude that: “… taurine deserves further consideration as a potential alternative for preventing liver injury caused by acetaminophen-overdose.” Clue: OD. Uncovering and bringing to public _____ the illegal goings on at Federal agencies is one of the best ways to help fight back. Clue: What you need to pay if you are going to increase your longevity. One of the most important effects of taurine is its crucial role in neurogenesis, the production of new _____ that takes place only in specific brain areas of adult mammals throughout life. Clue: Nerve cells. Taurine is an important protective substance that helps prevent liver _____ from occurring during the performance of the liver’s detoxification function. Clue: Harm.

ANSWERS TO AUGUST’S PUZZLE

Down 1.

Taurine has also been reported to suppress the sympathetic nervous system’s excessive activation which can cause _____. Clue: Heart on a rollercoaster (pl). 3. This author’s expertise in quality control and failure analysis resulted in receiving an award from the International Society for Testing and Failure Analysis for such highly respected work. Who is this? Clue: Last name. 4. According to William Gibson, what is not evenly distributed? 5. Acetaminophen-induced liver injury is the most common cause of _____ in the U.S. requiring hospitalization. Clue: Toxicity. 8. What are the initials of the author of this article who received the Award for Excellence in Health & Education from The Association for Holistic Health, and The James Lind Scientific Achievement Award? Clue: You don’t need one. You’re too smart. 9. A study reported that taurine reduces the expression of a number of inflammatory cytokines (such as tumor necrosis factor alpha), as well as reduces the activity of myeloperoxidase, a major source of _____ injury. Clue: A cardiac event that rhymes with poke. 13. A study reported that six weeks of treatment with taurine bromamine in patients with _____ resulted in improvement in 90% with a 65% reduction in lesions. Clue: A source of teen-age complexion angst that can extend into adulthood.

Crossword Contest Win a $10 credit toward a $50 purchase by: Submitting a correctly answered puzzle each month by the 15th of the next month. Send to: Attn: Dr. Joyce Block Life Enhancement Contest 2555 Business Parkway • Minden, Nevada 89423

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Life Enhancement Product Index Bestsellers in each category are highlighted in orange • Products containing ingredients featured in articles, ads, letters and news items in this issue are shown in boldface

ANTIOXIDANTS & HEALTH MAINTENANCE Acetyl L-Carnitine . . . . . . . . . . . . . . . . . . . . . .3 BioEnhance™ family Berberine Grape Power™ . . . . . . . . . . . . .17, 19 CoEnzyme Q10

Dr. Jonathan V. Wright’s … InsuLife™ family . . . . . . . . . . . . . . . .17, 19

Dr. Richard Clark Kaufman’s … NanoEGCG™ NanoGlutathione™ NanoResveratrol™

CARDIOVASCULAR SUPPORT CholestOut II™ CoEnzyme Q10

Dr. Jonathan V. Wright’s … InsuLife™ family . . . . . . . . . . . . . . . .17, 19 ThyroPlex™ . . . . . . . . . . . . . . . . . . . . . .C3

Dr. Richard Clark Kaufman’s … NanoEGCG™ NanoGlutathione™ NanoResveratrol™ PEGysomal Resveratrol™ ProBone-O Drops™

Durk Pearson & Sandy Shaw’s …

NanoSilymarin™ PEGysomal Resveratrol™

Durk Pearson & Sandy Shaw’s … AGEless™ BHT Plus™ Double C™ FoldRight™ Green Tea Booster EGCG Capsules™ ®

Hydrogen Power

Lycopene Harvest™ One-Per-Meal Radical Shield™ Party Pill II™ Personal Radical Shield™ Radical Shield Booster™ ShapeShifter Teas™ Stay Healthy Sodium Selenite™ SunPower Vitamin D3™

FoldRight™ Green Tea Booster EGCG Capsules™ Hydrogen Power® InnerPower™ family . . . . . . . . . . . . . . . .32 Lithium Plus™ Lycopene Harvest™ MealMate™ Niacin Easy 200™ Omega-3 Heart & Mind 600™ . . . . . . .C2, 25 On Target Magnesium Plus™ Potassium Basics™ ShapeShifter Teas™ SunPower Vitamin D3™ EDTA Chelator Complex™ Vein-Brain Tonic™

COGNITIVE ENHANCEMENT

Berberine Grape Power™ . . . . . . . . . . . . .17, 19

Acetyl L-Carnitine . . . . . . . . . . . . . . . . . . . . . .3 AshwaCalm™ Bacopa Vitality™ CDP-Choline CerebroPlex™ CholestOut II™ DHEA Original™ DMAE . . . . . . . . . . . . . . . . . . . . . . . . . . .4, 17

Dr. Jonathan V. Wright’s …

Turmeric Root Power™ . . . . . . . . . . . . . .25 V-Shield™ Lipoic Acid

BLOOD SUGAR MAINTENANCE & Mulberry MetaMind™ GLYCEMIC CONTROL Melatonin

InsuLife™ family . . . . . . . . . . . . . . . .17, 19

Dr. Richard Clark Kaufman’s … NanoGlutathione™ NanoSilymarin™

Durk Pearson & Sandy Shaw’s … AGEless™ Glycemic Control products Green Tea Booster EGCG Capsules™ Lycopene Harvest™ MealMate™ ShapeShifter Teas™ Lipoic Acid Mulberry MetaMind™ Sugar XE (LE)

BONE & JOINT SUPPORT Boswell Relief™ DHEA Original™

Dr. Richard Clark Kaufman’s … Bionic Joint Support™ NanoDHEA™ ProBone-O Drops™

Durk Pearson & Sandy Shaw’s …

SunPower Vitamin D3™

Durk Pearson & Sandy Shaw’s … BLAST™ family . . . . . . . . . . . . . . . . . . .C3 FoldRight™ GalantaMind Plus™ . . . . . . . . . . . . . . . .C2 Greater Rewards™ . . . . . . . . . . . . . . . . .C4 InnerPower™ family . . . . . . . . . . . . . . . .32 Lithium Plus™ Lycopene Harvest™ Memory Upgrade™ family . . . . . . . . . . . .C2 Mind Food™ Toolkit™ . . . . . . . . . . . .C2, 25 Omega-3 Heart & Mind 600™ . . . . . . .C2, 25 Turmeric Root Power™ . . . . . . . . . . . . . .25 GalantaMind™ Ginkgo Concentrate™ . . . . . . . . . . . . . . . . . . .4 Lipoic Acid Melatonin Mulberry MetaMind™ Phosphatidylserine Vein-Brain Tonic™ Vinpocetine . . . . . . . . . . . . . . . . . . . . . . . . . .3

ENERGY & ATHLETICS

SmartZyme™

Potassium Basics™

Dr. Richard Clark Kaufman’s … NanoDHEA™ NanoResveratrol™ PEGysomal Resveratrol™

NanoEGCG™

3-Way Calcium Complex™

InsuLife™ family . . . . . . . . . . . . . . . .17, 19

Dr. Richard Clark Kaufman’s … NanoResveratrol™ PEGysomal Resveratrol™

Durk Pearson & Sandy Shaw’s …

ESSENTIALS Durk Pearson & Sandy Shaw’s … Taurine ’n More™ . . . . . . . . . . . . . . . .5, 18

FAT LOSS, WEIGHT CONTROL, & APPETITE SATISFACTION 5-HTP 5-HTP SeroTonic II™

Dr. Jonathan V. Wright’s … InsuLife™ family . . . . . . . . . . . . . . . .17, 19

Dr. Richard Clark Kaufman’s … NanoEGCG™ NanoResveratrol™ PEGysomal Resveratrol™

Durk Pearson & Sandy Shaw’s … Glycemic Control products Greater Rewards™ . . . . . . . . . . . . . . . . .C4 Green Tea Booster EGCG Capsules™ Lycopene Harvest™ MealMate™ Potassium Basics™ Serene Tranquility™ ShapeShifter Teas™ Lipoic Acid Sugar XE

GASTROINTESTINAL SUPPORT Boswell Relief™ Bye-Lori™ family

Durk Pearson & Sandy Shaw’s … Lithium Plus™ Lycopene Harvest™ Potassium Basics™

GENE SUPPORT BioEnhance™ family

Dr. Richard Clark Kaufman’s … NanoResveratrol™ PEGysomal Resveratrol™

HORMONE SUPPORT DHEA Original™

Dr. Jonathan V. Wright’s … ThyroPlex™ . . . . . . . . . . . . . . . . . . . . . .C3

Dr. Richard Clark Kaufman’s … NanoDHEA™

Durk Pearson & Sandy Shaw’s … Stay Healthy Sodium Selenite™ Melatonin

HYGIENE SilverFresh™ Deodorant

IMMUNE FUNCTION Dr. Richard Clark Kaufman’s … NanoGlutathione™ NanoResveratrol™ PEGysomal Resveratrol™ SmartZyme™

Durk Pearson & Sandy Shaw’s … InnerPower™ family . . . . . . . . . . . . . . . .32 Lycopene Harvest™ Omega-3 Heart & 600™ . . . . . . . . . . .C2, 25 Self-Defensin™ V-Shield™

LIFESPAN SUPPORT Glucosamine Boost™

MEN’S HEALTH Dr. Jonathan V. Wright’s … MALE™ MaleRatio™ PropeL™ family ProsStay™ ThyroPlex™ . . . . . . . . . . . . . . . . . . . . . .C3

BLAST™ family . . . . . . . . . . . . . . . . . . .C3 Glucosamine Boost™ InnerPower™ family . . . . . . . . . . . . . . . .32 Durk Pearson & Sandy Shaw’s … Joint Principles™ Potassium Basics™ Lycopene Harvest™ MelaDose™ Pumping Iron™ ProsShield™ SynoGlide III™ Phosphatidylserine RedGidity™ Hydrogen Power is a registered trademark of Life Enhancement Products, Inc. Durk Pearson & Sandy Shaw is a registered trademark of Durk Pearson and Sandy Shaw.

CALL 800-543-3873

FAX 775-267-1544

www.life-enhancement.com

MOOD & SLEEP ENHANCEMENT 5-HTP 5-HTP SeroTonic II™ AshwaCalm™

Dr. Jonathan V. Wright’s … ThyroPlex™ . . . . . . . . . . . . . . . . . . . . . .C3

Durk Pearson & Sandy Shaw’s … Greater Rewards™ . . . . . . . . . . . . . . . . .C4 Lithium Plus™ Serene Tranquility™ Family SleepScape™ MelaDose™ Melatonin SleepTight™

NUTRITIONAL FOODS Durk Pearson & Sandy Shaw’s … BHT Plus™ Functional Gourmet™ MCT Oil Glycemic Control products High Oleic Sunflower Oil™ Sugar XE

PET HEALTH Dr. Richard Clark Kaufman’s … Dog’s Best Friend Canine Core Essentials™ Dog’s Best Friend Seeing Eye Drops™

PROSEXUAL Acetyl L-Carnitine . . . . . . . . . . . . . . . . . . . . . .3

Dr. Jonathan V. Wright’s … MALE™ PropeL™ family

Dr. Ward Dean’s … ProSexual Plus™

Durk Pearson & Sandy Shaw’s … InnerPower™ family . . . . . . . . . . . . . . . .32 Loving You™ Lycopene Harvest™ FemPM™ Plus Gel Ginkgo Concentrate™ . . . . . . . . . . . . . . . . . . .4 MacaLift™ RedGidity™ Tribulus Desire™

RESPIRATORY SUPPORT Boswell Relief™

Dr. Richard Clark Kaufman’s … NanoResveratrol™ PEGysomal Resveratrol™ SmartZyme™

Durk Pearson & Sandy Shaw’s … Pumping Iron™ V-Shield™

SKIN & HAIR CARE Dr. Richard Clark Kaufman’s … NanoGlutathione™

Durk Pearson & Sandy Shaw’s … Inner Shampoo™ Living Hair™ Living Skin™ Lycopene Harvest™ New Feeling™ Root Food II™ SilverFresh™ Deodorant

VISION & HEARING Dr. Richard Clark Kaufman’s … NanoResveratrol™ PEGysomal Resveratrol™

Dr. Seymour F. Trager’s … DinArrest™ i-C-u™ Eye D’Clare II™ VincaHear Plus™

WOMEN’S HEALTH Dr. Jonathan V. Wright’s … ThyroPlex™ . . . . . . . . . . . . . . . . . . . . . .C3

Dr. Richard Clark Kaufman’s … ProBone-O Drops™

Durk Pearson & Sandy Shaw’s … 3-Way Calcium Complex™ FemPM™ Plus Gel MacaLift™

SEPTEMBER 2014

PHONE ORDERS — PLEASE PROVIDE

Product List

LEM1409

Product Name

Product Description

3WC

3-Way Calcium Complex™ 120 caps, 30 serv, 1,000 mg

Complete calcium supplement with vitamins A, C, D, and boron

21.39

14.97

D60x50 DHEA Original™ 60 50-mg caps

Enhance energy, mood, memory, immune functions, sexuality & libido

22.64

15.85

5H90 x100

5-HTP 90 100-mg caps

Serotonin precursor

32.07

22.45

DA90

DinArrest™ 90 caps

Designed to support healthy hearing structure and function

57.10

39.97

ST-180 2 5-HTP SeroTonic II™ 45 serv in caps

Now with thiamine & hyperforin

71.39

49.97

DMAE

DMAE 120 125-mg caps

Maintain attention and memory function

14.27

9.99

ALC90 x500

Maintain memory function

59.96

41.97

DBFC

Dog’s Best Friend Canine Core Essentials™

For hip, joint, muscle & digestive support

57.10

39.97

142.81

99.97

DBFED Dog’s Best Friend Seeing Eye Drops™

Sterile eye drops for your dog’s irritation relief

45.67

31.97

Quantity, Amount

Acetyl L-Carnitine 90 500-mg caps

MSRP Your Price 30% Off MSRP

Key Code

Item Code

Product Name

Quantity, Amount

Product Description

MSRP Your Price 30% Off MSRP

AGL-LG AGEless™ 240 caps

Anti-AGE formulation for prolonged better health; economy size

AGL-SM AGEless™ 120 caps

Anti-AGE formulation for prolonged better health

82.81

57.97

Double C™ 180 caps, 608 mg Vitamin C

Water- and fat-soluble vitamin C, the classic antioxidant

42.81

29.97

ASC

AshwaCalm™ 120 300-mg caps

Calm down now with ashwagandha standardized to 1.5% withanolides

14.96

10.47

OE480

59.97

Bacopa Vitality™ 90 100-mg caps

Unique brain support 20% bacosides

15.70

Supports healthy cardiovascular system; with malic acid

85.67

EDTA Chelator Complex™ 480 caps

10.99

OEC

20.97

39.96

27.97

EDTA Chelator Complex™ Supports healthy cardiovascular 120 caps system; with malic acid 100 mg EDTA, malic acid & garlic

29.96

For multiple benefits, including support for healthy blood sugar levels

EYE

Eye D’Clare II™ About 200 drops

Now available online

45.67

31.97

EYE-1

Eye D’Clare II™ About 100 drops

Sterile eye drops for irritation relief

24.24

16.97

FBST

FastBLAST™ 37 serv, drink Phenylalanine with vitamin cofactors mix, 800 mg/serv phenylalanine and caffeine for very fast mental energy boost; citrus complex flavor

37.84

26.49

FemPM™ Plus Gel 15 g

21.38

14.97

For support of proper protein folding 107.10

74.97

BER

Berberine Grape Power™ 180 250 mg caps

BHT

BHT Plus™ 100 caps

Oil preservative

17.10

11.97

ENH

BioEnhance™ 60 serv, 360 caps

High-potency multivita/mineral/antioxidant

62.10

43.47

ENHD

BioEnhance with DNAble™ 120 serv, 480 caps

High-potency multivitamin/mineral/ antioxidant and gene supplement, with resveratrol

74.99

52.49

BJS

Bionic Joint Support™ 60 serv, 2 oz

Liposomal formulation for superior joint support

42.81

29.97

FGEL

BST

BLAST™ 44 serv, drink mix, 600 mg phenylalanine

Phenylalanine with vitamin cofactors and caffeine for mental fitness™, lemon tea flavor

38.53

26.97

FDR120

BST2

BLAST II™ sugar-Free 44 serv, drink mix 600 mg phenylalanine

Phenylalanine with vitamin cofactors and caffeine for mental fitness™, lemon tea flavor

38.53

26.97

MCT

BSTCP BLAST Caps™ 60 serv, 120 caps, 600 mg/serv phenylalanine energy

Phenylalanine with vitamin cofactors and caffeine for convenient quick

29.96

20.97

MCT16 Functional Gourmet™ MCT Oil Great tasting flexible salad and 16 fl oz cooking oil for fast energy & more

Boswell Relief™ 90 caps, 300 mg Boswellia

Maintains bowel, joint, and lung function

21.41

14.99

Bye-Lori™, 30 serv, 120 caps 1 g mastic/serv

Mastic for gastrointestinal support

44.99

31.49

BL2

Bye-Lori II™, 30 serv, 120 caps, 1 g mastic/serv

Mastic & phytonutrients for gastrointestinal support

54.99

38.49

BLP

Bye-Lori Plus™, 30 serv, 180 caps, 1 g mastic/serv

Mastic & phytonutrients, including turmeric, DGL & cinnamon, for advanced gastrointestinal support

71.39

49.97

CC60 x250

CDP-Choline (formerly CityCholine™)

Supports brain function 60 250-mg citicoline

49.63

34.74

CerebroPlex™ 30 serv, 180 caps

Support healthy cognitive function

74.99

52.49

Formulations are highlighted in blue

CO2

CholestOut II™ 30 serv, 120 caps

With policosanol and niacin for healthy cholesterol; now enriched with green & black tea polyphenols

44.99

31.49

Formulation is highlighted in purple

CoEnzyme Q10 (formerly Heart10™) 90 100-mg caps

Coenzyme Q10 for heart health support

89.96

D60x100 DHEA Original™ 60 100-mg caps

Enhance energy, mood, memory, immune functions, sexuality & libido

35.50

D60x25 DHEA Original™ 60 25-mg caps

Enhance energy, mood, memory, immune functions, sexuality & libido

10.84

CQ90 x100

FoldRight™ 120 serv, drink mix

Science-based female gel for antiaging prosexual use

Functional Gourmet™ MCT Oil Economy size 32 fl oz

GalantaMind™ 90 caps, 8 mg per capsule

Preventive help for memory function

41.39

28.97

22.10

15.47

125.67

87.97

Our Formulators Durk Pearson & Sandy Shaw ® Formulations are highlighted in yellow

High-Benefit–Reduced Cost Formulations are highlighted in orange Where you see this symbol, sales & discounts do not apply

Jonathan V. Wright, MD, Ward Dean, MD Seymour F. Trager, PhD Formulations are highlighted in green

62.97

Richard Clark Kaufman, PhD Formulations are highlighted in pink

24.85

Premier S I G N AT U R E L I N E

Where you see this symbol, sales & discounts do not apply 7.59

Other supplements on Product List are original formulations of Life Enhancement Products. Most products from Durk Pearson & Sandy Shaw and all products from Drs. Jonathan V. Wright, Ward Dean, Richard C. Kaufman, and Seymour F. Trager, are licensed exclusively to Life Enhancement Products.

Factory Direct Prices: 30% OFF MSRP Except for most books. Prices and discount amounts valid only from date of receipt through September 30, 2014. Not responsible for typographic errors.

L I F E enhancement

SEPTEMBER 2014

Item Code

GM-S

GMP

Product Name

MSRP Your Price 30% Off MSRP

Product Description

Quantity, Amount

GalantaMind™ 45 serv, Starter size; preventive 90 caps, 4 mg per capsule help for memory function GalantaMind Plus™ 180 caps galantamine, turmeric, lithium, quercetin & more

71.39

NOW WITH HESPERIDIN

49.97

169.96 118.97

The core product in Durk & Sandy’s preserve and protect memory function program

Item Code

Product Description

Living Skin™ 4 oz

Innovative carotenol antioxidant, nutrient moisturizer for improving the look and feel of dry, aging skin

27.84

19.49

Loving You™ 2 fl oz

Long-lasting sexual lubricant

14.24

9.97

NEW LOW PRICE

19.93

13.95

LYC

Lycopene Harvest™ by Durk Pearson & Sandy Shaw, 60 20mg softgels

Bioavailable antioxidant for cardiovascular health, immune function & more

GK90 x120

Ginkgo Concentrate™ 90 120-mg caps

Brain herb Sexual support

11.07

7.75

GCE

Glycemic Control Erythritol™ 1.1 lb, 125 serv

Natural sweetener, calorie-free, doesn’t promote tooth decay

27.10

18.97

GCFL

Glycemic Control Flour™ 1.3 lb, 40 serv

Flour for converting high-glycemic meals to low

25.67

17.97

MM240 MealMate™ 240 caps

Nutritional meal supplement for healthy weight management

GCN

Glycemic Control Nuggets™ 1.1 lb, 37 serv

Nuggets for converting high-glycemic meals to low

21.39

14.97

MEL-LQ

GCFK

Glycemic Control Quick Flakes™ 1.1 lb, 37 serv

Quick flakes for converting high-glycemic meals to low

21.39

14.97

MEL 60x3 MMR

Glycemic Control Resistant Starch™ 1.1 lb, 42 serv

Special starch that resists digestion (60% resistant), reducing glucose

28.53

19.97

Support healthy blood glucose levels, 11.36 mimicking a low carbohydrate diet

7.95

GCRS

Glucosamine Boost™ 120 caps 750 mg glucosamine

MSRP Your Price 30% Off MSRP

Product Name

Quantity, Amount

MacaLift™ 30 serv, 750 mg/serv

Supports enhanced libido

28.53

19.97

MALET

MALE™ 30 serv, 150 caps, 1.4 g arginine

Supports sexual function for the whole man

71.40

49.98

114.24

79.97

SPECIAL INTRODUCTORY PRICE MORE THAN 41% OFF MSRP

8.50

4.95

Melatonin 60 3-mg caps

Sleep well, support for jet lag

9.17

6.42

Memory Rules™ 30 serv, drink mix

Promotes mental energy and clarity

42.81

29.97

MMRCP Memory Rules™ 30 serv, 90 caps

Convenient capsules also contain theanine

35.67

24.97

Memory Upgrade™ 47 serv, drink mix, 1 g choline Zesty lemon flavor

Choline and vitamin B5 acetylcholine booster, supports brain function

41.39

28.97

MU2

Memory Upgrade II™ Choline, vitamin B5, taurine 90 serv drink mix

Added taurine

71.39

49.97

MU3

Memory Upgrade III™ Sugar free 90 serv drink mix

Important adjunctive product in Durk & Sandy’s preserve and protect memory function program

65.67

45.97

BTK

Mind Food™ Brain Maintenance Toolkit™ 1 GalantaMind Plus 1 Memory Upgrade III 1 Omega-3 Heart & Mind 600

Durk & Sandy’s full preserve and protect memory function program; Costs less than if purchased separately

MUL

Mulberry MetaMind™ 60 caps

Antioxidant, healthy blood sugar, and memory support

28.53

19.97

NSD

NanoDHEA™ 120 serv, 10 mg DHEA

State-of-the-art technology for greatly 28.53 enhanced DHEA bioavailability

19.97

NS EGCG

NanoEGCG™ 150 serv, 80 mg EGCG

State-of-the-art technology for greatly 42.81 enhanced EGCG bioavailability

29.97

NanoGlutathione™ 45 serv, 200 mg glutathione

Possibly the most bioavailable glutathione

85.67

59.97

MelaDose™ 90 mg

Uplift your Dopaminergic Reward System

57.10

39.97

SSTBC Green Tea Booster EGCG Capsules™ 90 caps

Boosts power of ShapeShifter Teas; 90% polyphenols (50% EGCG, 40% other)

28.53

19.97

High Oleic Sunflower Oil™ 16 fl oz

The ultimate healthy salad and cooking oil, with tocotrienols

32.81

22.97

HYP

Hydrogen Power® 60 serv, drink mix

Exciting new paradigm for antioxidant power

42.81

29.97

ICU

i-C-u™ 120 caps

For visual function sustainability

57.07

39.95

IPP

InnerPower Plus™ w/xylitol 30 serv, drink mix

Longer-lasting. Grape flavor

85.67

59.97

IPS

InnerPower™ w/xylitol, 30 serv, drink mix & more. Cherry flavor

GH releaser, sexual, memory, & immune enhancer, anti-inflammatory,

64.24

44.97

IPSST

InnerPower™ w/sweet stevia, 30 serv, drink mix

Tropical flavor

64.24

44.97

NSR

NanoResveratrol™ 60 serv, 100 mg resveratrol

Possibly the most bioavailable resveratrol

71.39

49.97

Inner Shampoo™ 8 fl oz

Hair rejuvenator and replenisher

14.24

9.97

NSS

NanoSilymarin™ 120 serv, 80 mg silymarin

Support liver function and blood sugar control

42.81

29.97

InsuLife™ 90 caps

Patented multiple insulin-function support

67.10

46.97

NF4

New Feeling™ 4 oz

29.96

20.97

IL-B

InsuLife-B™ 270 caps

With berberine for yet greater functionality

85.67

Original alpha-hydroxy rejuvenizing skin care lotion for softening and smoothing fine lines, age spots, and blemishes

59.97

Niacin Easy 200™ 180 200-mg caps

Support healthy cardiovascular function

22.81

15.97

O3HM6 Omega-3 Heart & Mind 600™ 150 softgels

Support heart and brain functions & 38.53 mood stability, with pharmaceutical quality, high concentration omega-3s

26.97

1PM

One-Per-Meal Radical Shield™ 84 caps

High potency multi-vitamin/mineral/ antioxidant, 3 capsules/day

25.67

17.97

OTM

On Target Magnesium Plus™ 180 66-mg caps

High bioavailability; heart function support

20.67

14.47

Party Pill II™ 180 caps

L-cysteine, vitamin C and more, detoxifier antioxidant formulation

48.53

33.97

Greater Rewards™ 180 caps

Joint Principles™ 120 caps

Chondroitin sulfate & glucosamine sulfate

28.54

19.98

LP250

Lipoic Acid 120 250-mg caps

The universal antioxidant

31.41

21.99

8.50

5.95

LIP

Lithium Plus™ by Durk Pearson & Sandy Shaw 90 caps Living Hair™ Combo pack

Important neuroprotective support Goes way beyond a spa vacation Inner Shampoo™ 8 oz plus Root Food II™ 120 caps

44.24

30.97

274.16 163.47 (40% Off MSRP)

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. CALL 800-543-3873

FAX 775-267-1544

www.life-enhancement.com

SEPTEMBER 2014

Item Code

Product Name

Product Description

MSRP Your Price 30% Off MSRP

Item Code

PEGysomal Resveratrol™ 60 serv, 10 mg

Maintain normal heart, brain, and gene function, and more

21.39

14.97

PRS

Personal Radical Shield™ 336 caps

High-potency multi-vitamin/mineral/ antioxidant, 12 capsules/day

71.39

49.97

PRS-B

Personal Radical Shield™ 994 g

Bulk powder

PS90

Phosphatidylserine 90 100-mg caps

Maintain quality of life, memory function

57.10

39.97

PB120

Potassium Basics™ 120 1053 mg caps

Supports healthy blood pressure, muscle mass, bones, and more

14.24

9.97

PB240

Potassium Basics™ 240 1053 mg caps

Economy size

22.81

15.97

ProBone-O Drops™ 60 serv, 1 mg B12, 1 mg folinic

High-potency liposomal formulation of B12 & folinic acid; cherry-flavored

28.53

19.97

PRP

PropeL™ 30 serv, 240 caps

Support healthy sexual function without hormonal risk

71.39

49.97

PRP2

PropeL II™ 30 serv, 240 caps

Support healthy sexual function now with lithium orotate

78.53

PSPC

ProSexual Plus™ 30 serv, 180 caps

The original dibencozide, sexual function support formulation

Quantity, Amount

205.67 143.97

MSRP Your Price 30% Off MSRP

Product Name

Product Description

SXE

Sugar XE™ 1.1 lb

Natural sugar substitute; all the benefits with none of the liabilities

19.96

13.97

SunPower Vitamin D3™ 120 2000-IU caps

High-dose vitamin D for multiple newly discovered benefits

14.24

9.97

SG3

SynoGlide III™ 120 serv, 240 caps

Ultimate joint maintenance with glu- 107.07 cosamine, chondroitin and rutin

74.95

TAM

Quantity, Amount

Taurine ’n More™ Drink mix

The two ingredients, taurine & bromine, are considered “Essentials”

8.5

5.95

TPXF 120

ThyroPlex™ for Women 120 caps, 15 mg thyroid

Support for thyroid & other glandulars

114.24

79.97

TPXF

ThyroPlex™ for Women 30 caps, 15 mg thyroid

Support for thyroid & other glandulars

38.53

26.97

TPXM 120

ThyroPlex™ for Men 120 caps, 15 mg thyroid

Support for thyroid & other glandulars

114.24

79.97

54.97

44.24

30.97

TPXM

ThyroPlex™ for Men 30 caps, 15 mg thyroid

Support for thyroid & other glandulars

38.53

26.97

PROS3 ProsShield™, 90 serv, 270 Support normal prostate caps; 10 mg lycopene, 320 mg function, with gamma-tocopherol saw palmetto and 240 mg stinging nettle root per 3 capsules

89.96

62.97

PST

ProsStay™, 90-180 serv, 180 caps; 20 mg vitamin K3 and 2 g vitamin C per 3 capsules

Support healthy prostate function

49.97

34.98

PFE

Pumping Iron™ 60 caps

Advanced iron support

35.67

Tribulus Desire™ 90 caps, 250 mg Tribulus

Traditional herbal libido tonic

14.77

10.34

TurboBLAST II™ 54 serv, drink mix, 650 mg phenylalanine

Phenylalanine w/vitamin cofactors, polyphenols, & grape-seed extract for mental fitness™; grape flavor

48.53

33.97

24.97

TRP

Turmeric Root Power™ 240 600 mg caps

Supports healthy joints, brain function, and much more

28.53

19.97

Unsurpassed complete formulation for vein & brain support

85.64

59.95

Hearing function support with magnesium, niacin, ginkgo & lipoic acid

28.56

19.99

V120x10 Vinpocetine 120 10-mg caps

Nutrient for mental function

25.63

17.94

V-Shield™ 180 caps

Natural immune system support for healthful viral resistance

71.39

49.97

WOW

WOW™ 74 serv drink mix, 1 kg 600 mg phenylalanine

Cherry-berry-flavored member of the BLAST™ family

57.07

39.95

Radical Shield Booster™ 90 caps

Vitamins B2, B3, C, and E plus taurine, quercetin, and hesperidin

27.84

19.49

VTII

RedGidity™ 180 450-mg caps

Korean red ginseng to support normal, healthy sexual function

22.21

15.55

VHP 120

Root Food II™ 120 caps

Nutritional hair support with L-cysteine and more

36.41

25.49

SD60

Self-Defensin™ 60 caps

Powerful healthy immune function support

24.24

16.97

ST-D

Serene Tranquility™ Day with 5-HTP Drink mix

For improved calmness & enhanced productivity; lemon-lime flavor

54.24

37.97

Serene Tranquility™ Night with 5-HTP Drink mix

With melatonin; for improved calmness, support of better sleep, & enhanced productivity; cherry flavor

57.10

ST-N

Vein-Brain Tonic™ 180 caps, 10 mg TTFCA VincaHear Plus™ 120 caps

39.97

Item Code

Product Name

Quantity, Amount

Product Description

ST-NT

Serene Tranquility™ Night with Tryptophan Drink mix

With melatonin; for improved calm71.39 ness, support of better sleep, & enhanced productivity; lemon-lime flavor

49.97

SST

ShapeShifter Teas™ 90 serv

Special selection of teas for healthy weight management

57.10

39.97

BSTC

Better Sex Through Chemistry

Morgenthaler & Joy

8.50

4.95

BACK ISSUE

Life Enhancement Back Issues Life Enhancement Magazine

DEO

SilverFresh™ Deodorant, 4 fl oz

SPECIAL INTRODUCTORY PRICE MORE THAN 41% OFF MSRP

MSRP Discount as Shown

Books & Reference Nonreturnable, Discounted as Shown 14.95

7.48 (50% Off)

Selected issues available back to 2003; plus postage

4.95

3.71 (25% Off)

1-year subscription

—

9.95

1.99

SLS30

SleepScape™ 30 serv

Get More Out of the Sleep You Get™ 42.81

29.97

LEP MAG

SLS45

SleepScape™ 45 serv

Economy size

57.10

39.97

REPRINT Life Enhancement Reprints

Reprints from all issues available; plus postage

SDVD SleepTight™, 30 serv, 90 caps

Sleep naturally, awake refreshed

18.09

12.66

The latest cutting-edge research for improving health and extending life

249.99

SLT

79.95 (68% Off)

SmartZyme™ 90 serv, 180 caps

Enzymes for joint support and more

57.10

39.97

BKNGRS The New Glucose Revolution Shopper’s Guide

Brand-Miller, Wolever, Foster-Powell, Colagiuri

11.97

VT1

16.95

Stay Healthy Sodium Selenite™ by Durk Pearson & Sandy Shaw, 90 caps

NEW LOW PRICE

7.07

4.95

Pearson v. Shalala and Bulwark of Liberty Awards

Videotape

SHSS

SD2

Smart Drugs II: The Next Generation

Dean, Morgenthaler, & Fowkes Your choice FREE with $50 Order

14.95

7.48 (50% Off)

Selenium in a form that makes all the difference

Life Enhancement Symposium DVD Set

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

L I F E enhancement

SEPTEMBER 2014

Life Enhancement Mail Order Form Item Code

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LEM1407 LEM1409 At least 30% Off MSRP, except for most books

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Nevada residents add 6.85% sales tax Shipping

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Except Alaska, Hawaii, & Puerto Rico *First 5 lbs ship free. Normal shipping charges apply to any amount above 5 lbs. Ground shipping of our choice. Free shipping cannot be combined with any other offer.

COMMERCIAL CARRIER OR U.S. PRIORITY MAIL (1st 5 lbs) 1– 5 Days Ground $7.50

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Check enclosed. Please do not send cash in the mail. Make checks payable to Life Enhancement Products. Mail to 2555 Business Parkway, Minden, Nevada 89423.

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For Orders by Check: In order to expedite your delivery, we reserve the right to adjust any order that was received underpaid or without sufficient shipping costs.

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CALL 800-543-3873

FAX 775-267-1544

www.life-enhancement.com

SEPTEMBER 2014

Please provide Key Code:

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PHONE ORDERS

CLIENT RELATIONS IS OPEN MON–FRI 7–5 Pacific Time Orders placed on major holidays, including telephone orders left by voice mail, will ship the next business day.

5 Ways to Order or Send a Friend a FREE Subscription to Life Enhancement Phone 800-543-3873 (USA only) 775-783-1600 Fax 775-267-1544 Web www.life-enhancement.com E-mail info@life-enhancement.com Mail Life Enhancement Products 2555 Business Parkway Minden, Nevada 89423

GUARANTEE We fully guarantee the quality of every product we sell. This guarantee certifies that our products are manufactured to the highest standards of potency, purity, and freshness. If you are not satisfied in every way, return the unused portion within 30 days of receipt, and we will offer you a full credit toward another purchase or refund 100% of your purchase price (refunds do not include shipping costs). You’ll still keep the 2-year subscription to Life Enhancement, which is free for every client, $19.95 if ordered separately!

INTERNATIONAL ORDERS Free shipping is not available with international orders. Please call for best rates. Otherwise, shipping costs will be added, and your order will be shipped via our preferred carrier, UPS (International Economy rate). For lowest rates, we suggest USPS services such as International First Class Mail or Priority Mail International. All international orders must be paid in US dollars. All orders paid by International Money Order must include shipping costs. If you wish to mail-order internationally, we suggest that you call ahead for an accurate order total. Customs, duties, taxes, etc., are your responsibility. Please check with your local customs agent to ensure that products you wish to obtain can be accepted into your country. Life Enhancement Products cannot be responsible or liable for customs delays or seizures.

S U P P L E M E N T FAC T S Serving size 1 heaping tbsp Servings per container 30

Amount Per Serving

Durk Pearson & Sandy Shaw’s® InnerPower™ and InnerPower Plus™ help to trigger your own internal biochemical resources of mental and physical power for feeling more vital and youthful.* Both InnerPower and InnerPower Plus combine arginine, choline, citrulline, magnesium aspartate chelate, glycine, and betaine, as well as folic acid and vitamins B5, B6, and B12, among many other vital nutrients—all in a delicious drink mix to help restore more youthful function

Vitamin A (as beta-carotene)* 2495 IU Vitamin C (ascorbic acid) 500 mg Vitamin E (as d,l-alpha-tocopheryl acetate) 120 IU Vitamin E (as mixed tocopherols, with 11 IU 40% gamma-tocopherol)

to your hypothalamus and pituitary gland, which are responsible for the production and natural release of human growth hormone.* InnerPower Plus also contains gamma-tocopherol, coenzyme Q10, and a greater amount of magnesium aspartate chelate, along with a soluble fiber. For the proper functioning of your memory, immune system, muscles, and sexuality*

Vitamin B6 (as pyridoxine hydrochloride) Folic acid Vitamin B12 (cyanocobalamin) Pantothenic acid (vitamin B5 as calcium pantothenate) Calcium (as calcium pantothenate and calcium borate) Magnesium (as magnesium aspartate) Zinc (as zinc gluconate) Copper (as copper gluconate) Chromium (as chromium polinicotinate) Arginine Malic acid Barley flour Glycine Betaine (trimethylglycine free base) Choline (as choline dihydrogen citrate) Citrulline Taurine Coenzyme Q10 Boron (as calcium borate)

12 700 200 500

mg mcg mcg mg

% Daily Value 50% 833% 400% 36% 600% 175% 3333% 5000%

57 mg 133/267 mg 3 mg 420 mcg 27 mcg 6 g 2 g 1 g 1 g 1 g 670 mg 500 mg 200 mg 30 mg 2 mg

6% 33/67% 21% 21% 22% † † † † † † † † † †

* Only in the Cherry- and Tropical-flavored InnerPower formulations. † Daily Value not established.

Red print denotes InnerPower Plus Also contains: Natural flavors, citric acid, silicon dioxide, fumaric acid, acesulfame-K, natural colors and xanthan gum. Tropical flavor only: Stevia. (Stevia rebaudiana). Cherry flavor and InnerPowerPlus: Xylitol & sucralose.

InnerPower™ $4497 reg $64.24 Cherry flavor with xylitol or Tropical flavor with sweet stevia 30 serv

InnerPower Plus™ $5997 reg $85.67

Grape flavor 30 serv

statements have not been evaluated by the Food and Drug Administration. *These These products are not intended to diagnose, treat, cure, or prevent any disease.

There have been a few reports that high dietary levels of arginine may cause reactivation of latent herpes viruses in a few susceptible individuals. If this occurs, discontinue use.

L I F E enhancement

SEPTEMBER 2014

Each new day presents challenges that, if not met and overcome, may leave you less fit mentally to control your life … to achieve your financial goals … to set the stage for pursuing your personal happiness. Now there’s a way to insure against the consequences of falling short of your goals and to offer you more control over your life. By starting each day with a cool, refreshing glass of delicious BLAST (or BLAST II, FastBLAST, Memory Rules, TurboBLAST II, or WOW), you can embrace a Mental Fitness™ program that can Lemon Tea Lemon Tea Orange Citrus Complex blow away your neural cobwebs and blast away the financial storm BLAST ™ BLAST II™ FastBLAST ™ clouds that may hold you back.* Sugar Free Life extension scientists Durk Pearson & 80 mg caffeine 80 mg caffeine 80 mg caffeine Sandy Shaw® have developed a family of 600 mg phenylalanine 600 mg phenylalanine 800 mg phenylalanine products for their own personal use 44 servings 44 servings 37 servings based on the idea of providing our $2697Reg. $38.53 $2697Reg. $38.53 $2649Reg. $37.84 brains with nutrient raw materials to manufacture neurotransmitters such Concord Grape Cherry Berry as noradrenaline, which provides an Lemon Citrus Complex adrenaline-like charge to neural Memory Rules™ TurboBLAST II™ WOW ™ circuits.* 38 mg caffeine These BRAIN DRINKS are the 650 mg phenylalanine 80 mg caffeine 80 mg caffeine High polyphenols core of Durk & Sandy’s personal 600 mg phenylalanine 600 mg phenylalanine Mental Fitness program. Each formulation 30 servings 54 servings 74 servings $2997Reg. $42.81 $3397Reg. $48.53 $3995Reg. $57.07 contains the essential amino acid phenylalanine and the necessary enzyme cofactors vitamin B6 , vitamin C, ALSO AVAILABLE IN CONVENIENT CAPSULES copper, and folic acid, along BLAST Caps™ Memory Rules™ with natural flavors. 60 mg theanine With these BRAIN DRINKS 80 mg caffeine 70 mg caffeine as your daily allies, you can 500 mg phenylalanine 600 mg phenylalanine take charge of your life. So 30 servings 60 servings have a glass … Your mind $2497Reg. $35.67 $2097Reg. $29.96 is in your hands.

turn back the clock

Pr A

em R

of your ENDOCRINE system

ThyroPlex contains glandular thyroid, adrenal, hypothalamic, pituitary, and testicular or ovarian tissue. Principal ingredients are derived from New Zealand livestock. ™

No case of mad cow disease has ever been reported in New Zealand, which has had stringent controls in place since 1989 to prevent this from occurring. As an extra precaution, we have our thyroid products tested by an independent laboratory in the United States to ensure that they are safe to use. What’s the lowdown on low-dose thyroid? According to a study conducted by James Isaacs, a pioneering Each 1-capsule serving has cardiovascular surgeon these bovine glandular extracts: in Baltimore, people • Thyroid, whole 15 mg who took 1⁄4 grain of • Hypothalamus 200 mg thyroid over a period of • Pituitary, anterior 150 mg 10 years had a • Adrenal 200 mg significant improvement • Testicle or Ovary 50 mg in cardiovascular

ier

function.* (One serving of ThyroPlex contains the equivalent of 1⁄4 grain thyroid.) Research also indicates that proper thyroid function is associated with: • Enhanced energy levels* • Enhanced libido function* • Improved memory function* • Elevated mood* Who Should Use ThyroPlex? Per Dr. Wright, this product is for you if you have no overt endocrine disease and are over 40 (because this is when all the endocrine glands are going to start slowing down). Jonathan V. Wright, M.D.’s

ThyroPlex™ for Men ThyroPlex™ for Women

2697 $7997 30 caps Reg. $38.53 120 caps Reg. $114.24

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

PRSRTD STD

STARTING NOW

US POSTAGE PAID

BUY TWO–GET ONE

FREE!

LIFE ENHANCEMENT PRODUCTS, INC.

2555 Business Parkway Minden, Nevada 89423

When you order any TWO of the SAME Life Enhancement product, you’re entitled to one additional product (of equal or lesser value) FREE! You may order as many products as you’d like, and there’s no minimum order.

Mention Code BCM1409

1-800-543-3873

Phone, mail, or fax orders only Offer ends Sept. 30, 2014.

Does not apply to Premier Signature Line or to HighPotency–Reduced Cost Line Cannot be combined with other promotions. All items must be shipped to the same U.S. address.

Does not include free shipping.

Phone Orders 800-543-3873 SAME DAY SHIPPING See Mail Order Form on page 31

Announcing Durk Pearson & Sandy Shaw’s® Greater Rewards™ Capsules

You Can Have a More Rewarding Life! Now You Can Have Greater Rewards in Life for Everything that You Accomplish

e are proud to introduce Durk Pearson & Sandy Shaw’s new Greater Rewards capsules. One of the principal ingredients is EGCG, a major polyphenolic catechin found in green and white tea. EGCG is able to do many things, one of which is its ability to uplift the Dopaminergic Reward System by inhibiting COMT (catechol-O-methyltransferase). COMT is an enzyme that degrades catecholamines (including dopamine and adrenaline/noradrenaline). When not degraded, catecholamines can be powerful elements for enhanced human behavior and, indeed, the pursuit of happiness. Durk & Sandy designed their formulation containing EGCG (and several other important co-factors) specifically for the purpose of promoting greater rewards and a rewarding life. Another ingredient they added to Greater Rewards is Taurine, an amino acid that increases dopamine levels in the dopamine reward system. Vitamin C has been found to help maintain catechin content, so it too was added to Greater Rewards to help protect the bioavailability of EGCG. Then they included Quercetin because the combination of quercetin and EGCG acts together synergistically to inhibit COMT. Another ingredient in Greater Rewards is Thiamine, an essential vitamin that induces dopamine release. Finally, there is Hesperidin for neurogenesis, the creation of new neurons. These new brain cells can help maintain the ability to learn throughout life and, moreover, deal with complex self-rewarding and more youthful cognitive activities. • Now you can get more sense of reward from the same actions, by increasing your brain’s perception of reward • Now you can receive more pleasure and motivation • Now you can increase your zest for living • Now, just knowing you gave the right answer can provide rewards independent of a money payment ™ • As a bonus, the combination of ingredients in Greater Rewards may help improve satiety by creating an abundance of dopamine reward signaling which might help Factory Direct Price you to avoid the need for “comfort food” 97 Just $ Greater Rewards can help you find greater happiness, more satisfaction, and Reg. $57.10 enhanced productivity throughout the arenas of your life. In other words, you can have greater rewards and a more rewarding life! Caution: Not for schizophrenics

Greater Rewards

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.