PENN DENTAL MEDICINE VERNON BRIGHTMAN RESEARCH SOCIETY NEWSLETTER
Dear Penn Dental Medicine,
We are excited to present the Winter 2024-25 edition of PDM Explorer, brought to you by the Vernon Brightman Research Society (VBRS). As the primary student research organization at Penn Dental Medicine and the local chapter of the National Student Research Group (NSRG) affiliated with the American Association for Dental, Oral, and Craniofacial Research (AADOCR), VBRS plays a vital role in connecting research activities at PDM with the broader student community. Named in honor of Dr. Vernon J. Brightman, a former faculty member and passionate advocate for student research, VBRS has carried forward his vision for more than twenty years. We take pride in our ongoing commitment to promoting interest and active involvement in innovative research across basic science, clinical practice, and public health within the dental field. In this thirteenth edition of PDM Explorer, we are thrilled to share the latest developments and our continued efforts to inspire student engagement in research at Penn Dental Medicine.
To kick off the fall semester, we hosted a virtual Research Speed Dating Event, bringing together student mentors with expertise in basic and translational sciences, clinical research, and public health both at PDM and NIH/NIDCR. The event aimed to provide a snapshot of the broad and ever-evolving field of dental research, as well as to create a platform for student researchers to share their experiences and what motivated them to be involved with research. With continuous advancements in technology and innovation, the research landscape is expanding, as demonstrated by the diverse areas of expertise represented by our student panel. This event highlighted the wide range of research opportunities available to students across various disciplines.
The highlight of the semester was our Annual Student-Faculty Research Mixer. With over 80 students and faculty of a wide array of disciplines participating, the event was a vibrant hub for networking and collaboration, providing a strong boost to student research at PDM. We are energized and inspired to continue advancing our mission of promoting and expanding student research at Penn Dental Medicine in the years to come.
In this edition of the PDM Explorer, we are excited to spotlight some of the exceptional students and faculty who are at the forefront of driving research innovation and progress at PDM and beyond. You will also have the opportunity to read about our NSRG Nominee for PDM and a Resident Spotlight. We remain committed to advocating for increased student involvement in research and are grateful for your continued support. We hope you enjoy the Winter 2024-25 edition of PDM Explorer
Sincerely,
Vernon Brightman Research Society Executive Board
The Vernon Brightman Research Society (VBRS) Executive Board members for the current academic year include the following individuals. They invite students with an interest in research to join VBRS.
CO-PRESIDENTS: Jessica Hao D’26 (1) and Julie Hong D’26 (2)
D1 REPRESENTATIVES: Alyssia Liu D’28 (12), Jake Feldman D’28 (13), and Jeslyn Mei D’28 (14)
VBRS is the primary student research organization at Penn Dental Medicine. Named in honor of Dr. Vernon J. Brightman, a former PDM faculty member and proponent of student research, VBRS has created opportunities and gathered resources for students to help find their niche in research. The society promotes interest, participation, and appreciation of basic and clinical oral health research that keeps dentistry a science and research-based profession. VBRS is PDM’s chapter of the American Association for Dental, Oral and Craniofacial Research (AADOCR) National Student Research Group. Dr. Kang Ko, Associate Professor in the Department of Periodontics, and Dr. Esra Sahingur, Associate Dean of Graduate Studies and Student Research and Associate Professor in the Department of Periodontics, are the VBRS faculty advisors.
This newsletter highlights students’ research accomplishments, past and upcoming events, and student and faculty interviews.
UPCOMING EVENTS
VBRS PROPOSAL WRITING WORKSHOP
This Spring, VBRS will be hosting our annual proposal writing workshop to aid students applying to the Summer Research Program and Research Honors. Dr. Kang Ko will explain the different components and requirements of the proposal. Anyone interested in applying to these programs should stay tuned for updates on the exact date and plan on attending this workshop.
ACCE DAY 2025
The 4th annual Advances in Clinical Care and Education Day (ACCE) will take place on May 15th, 2025. This event will showcase PDM’s initiatives in clinical care, education and community outreach. ACCE day was created to celebrate the great amount of clinical and educational achievements at PDM. This is a wonderful opportunity to hear about the clinical accomplishments of students and faculty.
RESEARCH DAY 2025
On April 16th, 2025 , PDM will come together for Research Day to celebrate student and faculty research. The event will be held in-person this year. This exciting event will be filled with numerous presentations given by faculty and guest speakers, as well as poster sessions from students in the Summer Research Program and Research Honors. Furthermore, student and junior research will be recognized with the selection of the 2025 AADOCR Travel Grants. Research Day is a great all-day event to learn about the innovative research that is going on in the school.
RESEARCH SPEED DATING EVENT
The annual VBRS Research Speed Dating event took place virtually on September 19th, 2024. This event granted PDM students the opportunity to speak with other students involved with research both inside and outside of the dental school. The student research panel consisted of students with a variety of research experiences such as the summer research program, research honors, independent projects, etc. This event served as an excellent resource to students interested in pursuing research during their time at PDM.
RESEARCH SPEED DATING PANEL
RESEARCH HONORS
Dayoon Chang D’27 dayoonc@upenn.edu
Sherry Schneider D’27 sherry31@upenn.edu
CLINICAL RESEARCH
Peyton Maccarone D’26 pmacc@upenn.edu
Mary Pappandreas D’26 marypapa@upenn.edu
INDEPENDENT RESEARCH
Taylor DeVine D’27 taydev@upenn.edu
LEONARD DAVIS INSTITUTE
Lauren Hogstrom D’26 lhogst@upenn.edu
Lindsay Zhang D ‘27 lxz@upenn.edu
Liam Safran D’27 lsafran@upenn.edu
VBRS
Faculty/Student Research Mixer
VBRS held our annual Faculty/Student Research Mixer on November 15th, 2024 in the Lerner Pavilion of Penn Dental Medicine. The event featured numerous renowned PDM faculty members who are currently performing research and students were given the opportunity to interact directly with faculty to ask them questions about their work. This event was a huge success and allowed PDM students to learn about the variety of research opportunities available at the school.
NIH RESEARCH
Bisrat Demissie D’27 bisrat@upenn.edu
SUMMER RESEARCH
John Button D’26 jbutton@upenn.edu
Adam Bouhamdan D’27 adambou@upenn.edu
Caroline Palmer D’27 cep227@upenn.edu
Winslow Wanglee D’27 wwanglee@upenn.edu
FACULTY
FEATURED AT THE EVENT
Dean Dr. Mark Wolff, Dr. Claire Mitchell, Dr. Kang Ko, Dr. Esra Sahingur, Dr. Helen Jeon, Dr. Chider Chen, Dr. Fusun Ozer, Dr. Adeyinka Dayo, Dr. Chenshuang Li, Dr. Dana Graves, Dr. Alonso Carrasco-Labra, Dr. Kari Hexem, Dr. Katherine Theken, Dr. Henry Daniell, Dr. Yucheng Chang, Dr. Marco
Tizzano, Dr. Eugene Ko, Dr. Alicia Risner Bauman, Dr. Flavia Teles, Dr. Qunzhou Zhang, Dr. Katherine France, Dr. Myra Laird.
STUDENT PROGRAMS
STUDENT RESEARCH
PROGRAMS // Requirements and Deadlines
SUMMER RESEARCH PROGRAM
The Summer Research Program is for current Penn Dental Medicine students to engage in a basic laboratory or clinical research project. The purpose of the program is to give interested dental students a chance to experience both basic and clinical dental research from a “hands-on” perspective by participation in an ongoing faculty research investigation. Student researchers are expected to work full time during the summer and continue their research throughout the academic year with a faculty advisor on a mutually agreed research project.
REQUIREMENTS TO APPLY:
• Complete the application
• Research proposal
• Good academic standing
• Able to commit full time on their research projects during the summer
• Basic training in Laboratory Safety and Bioethics in Research
APPLICATION DUE DATE: March 14, 2025
CONTACT:
Dr. Esra Sahingur, Associate Dean of Graduate Studies and Student Research, sahingur@upenn.edu
Summer Research Program Application: https://app.smartsheet.com/b/ form/876df5fb267f4d3b8ef 9ba079dc341f1
BASIC & TRANSLATIONAL RESEARCH HONORS PROGRAM
The Honors in Research Program is open to students in their first or second year at PDM. The competitive honors program is designed to cultivate a leadership outlook in a select group of exceptional students and enable them to develop the skills to leverage their leadership potential in the following honors areas; Basic and Translational Research, Clinical Dentistry, Clinical Research, Community Health, Endodontics, Oral and Maxillofacial Surgery, Orthodontics, Pediatric Dentistry, Vulnerable Populations, Periodontics as well as Radiological Sciences. All Honor students present their work at the annual Penn Dental Research Day, are required to write a Research Honors thesis, and may be eligible to compete for many school-wide research travel grants and awards.
REQUIREMENTS TO APPLY:
• Complete the application
• 1st or 2nd year student
• Minimum undergraduate science GPA of 3.5
• Minimum GPA of 3.25 in every semester of dental school
• Letter of recommendation of past or present research supervisor
• Thorough research proposal
• Timeline for project completion
APPLICATION DUE DATE: March 1, 2025
CONTACT:
Dr. Kathleen Boesze-Battaglia, Director of Honors Program, battagli@upenn.edu
LEONARD DAVIS INSTITUTE SUMMER RESEARCH FELLOWSHIP
“Penn Dental Medicine in collaboration with the Leonard Davis Institute of Health Economics and the Health Care Management Department of the Wharton School supports stipend-based summer research fellowships for dental students interested in working on a health services or health policy research project during the summer between their first and second year of dental school.” Depending on available mentors, research opportunities are extremely diverse from relevant to oral healthcare to faculty somewhere else on the Penn campus. At the conclusion of the 10-12 week program, students present their research findings to faculty, staff, and fellow participants.
REQUIREMENTS TO APPLY:
• Online application form
• Resume
• Headshot
• Two (2) letters of recommendation. The letters of recommendation should address your academic accomplishments and related research experience.
• The letters of recommendation should be sent directly from the recommender to Joanne Levy as a PDF attachment.
APPLICATION DUE DATE: February 15, 2025
APPLICANT INTERVIEWS: March 2025
ADMISSIONS NOTIFICATIONS: April 2025
CONTACT:
Joanne Levy, Founding Director, SUMR Program and Director of Student Initiatives, Penn LDI, levyj@wharton.upenn.edu
Margaret Yang, MseD, Director of Student Affairs and Engagement, Penn Dental Medicine, xiaojiao@upenn.edu
Students interested in pursuing a dual-degree program must submit an application to the PDM Dual-Degree Admissions Committee during the spring of their first year. The close association between Penn Dental Medicine and other professional schools, departments, and divisions of the University affords unique opportunities for exceptional students able to meet the rigorous application standards of both Penn Dental Medicine and a second program at the University of Pennsylvania. Students interested in an academic career most often consider the dual-degree option. A student enrolled in a dual degree program must complete the Master’s program prior to obtaining the DMD diploma.
The current dual-degree options are Master of Bioethics, Master of Public Health, Master of Science in Bioengineering, Master of Science in Higher Education, Master of Science in Nutrition Science, Master of Science in Oral and Population Health, Master of Science in Translational Research, Master’s in Law, Juris Doctor in Law, and Master of Business Administration. Each program has different admissions standards.
2025 IADR/AADOCR/CADR Annual Meeting & Exhibition will be held on March 12-15, 2025 in New York, NY. The event will include oral and poster presentations, distinguished lecture series, and an exhibit hall. Students may submit abstracts of their research to be considered. Accepted students will present their research poster or oral presentation at the symposium.
MORE INFORMATION: https://www.iadr.org/events/upcomingevents/2025-aadocrcadr-annual-meetingexhibition
If you are interested in pursuing research, please fill out the Research Opportunities Request form: app.smartsheet.com/b/ form/5c5c363bdba34ed1abbdb103ba18ffe1
Questions about student research at PDM can be directed to: PDMStudentResearch@dental. upenn.edu
Jessica Winarto, D’26 Summer
Research Program
HOW DID YOU GET INVOLVED WITH RESEARCH AT PDM?
I looked through the various research faculty on PDM’s website which included their research focus, to help me narrow down the PI(s) I want to reach out for research opportunities. Then, before emailing the PI to set up an initial meeting, I made sure to read some of their past publications to gauge my interest in their research focus.
CAN YOU DESCRIBE YOUR RESEARCH?
I am currently studying about the mechanism underlying the anti-cancer effect of metformin and melatonin on oral squamous cell carcinoma cells.
WHAT MADE YOU DECIDE TO PARTICIPATE IN THE SUMMER RESEARCH PROGRAM?
Practically speaking, I wanted more time and flexibility to complete the research project that was started in D1 summer. Previously in undergrad, I was mostly doing benchwork — running gels and tissue culturing for other people’s projects. Overall, I participated in the research honors because it was an opportunity to have more independence in conducting a research project, which I did not have in undergrad.
DO YOU HAVE ANY FUTURE PLANS WITH YOUR RESEARCH?
I hope to attend the AADOCR 2025 conference! In the future, I would like to remain involved in academia, potentially applying for PhD, and continue practicing clinically.
WHAT DO YOU THINK IS THE MOST IMPORTANT QUALITY OF AN EFFECTIVE RESEARCHER?
Having the willingness to learn from others and your own failures (no matter how silly it is!). It is okay to feel discouraged. If you are not being challenged, you are not learning!
FUN FACT?
I (unintentionally) have too many Avocado things...Avocado plushies, scrub caps, bed sheet set, water bottle.
“Having the willingness to learn from others and your own failures (no matter how silly it is!). It is okay to feel discouraged. If you are not being challenged, you are not learning.”
JESSICA WINARTO, D’26
2024 DMD RESEARCH
SUMMER RESEARCH STUDENTS
SYDNEY BOHM
The Role of NF-kB in Mesenchymal Stem Cells during Tensile Force-induced Bone Remodeling
Faculty advisor: Hyeran Helen Jeon
ADAM BOUHAMDAN
BTO Incorporation in ZrO2: Impact on Bacterial Adhesion and Transcriptomic Responses Across Planktonic and Ecological Levels
Faculty advisor: Geelsu Hwang
BRYCE BRANDFON
CPAP Effect on Post-Implant Placement Pain
Faculty advisor: Brian Ford
ZHAOXU CHEN
IL33+ Fibroblasts Activate Regulatory T Cells to Facilitate Rapid Wound Healing in Oral Cavity
Faculty advisor: Kang Ko
BRANDON CHIN
Single Nucleotide Polymorphisms To Predict The Analgesic Response To Ibuprofen Following Third Molar Extraction
Faculty advisor: Katherine Theken
RYAN ELDER
Analysis of Adolescent Perception of HPV and COVID-19 Vaccinations in the Dental Setting
Faculty advisor: Katherine France
MATTHEW HALPERT
Patients’ Attitudes Towards Receiving the HSV and HPV Vaccines from Dentists
Faculty advisor: Katherine France
NAM LE
Cytolethal Distending Toxin Regulation on Osteoclastogenesis
Faculty advisor: Taewan Kim
EMMA LINN
Investigating PTSD and Depression in Implant Failure
Faculty advisor: Brian Ford
ELISA LIPKIN
The Significance of SCFAs in the Pain Responses of Third Molar Extraction Patients
Faculty advisor: Katherine Theken
CHRISTIAN MASTROIANNI
Platyrrhine Bite Force-Gape Tradeoffs
Faculty advisor: Myra Laird
MARCO MCGOWAN
Assessment of Lipid Dysregulation Pathways in Human CHM Patients and CHM^null/wt Mouse
Faculty advisor: Kathleen Boesze-Battaglia
CAROLINE PALMER
The Role of NF-kB in Mesenchymal Stem
Cells on Osteogenesis during Mechanical Force-induced Bone Remodeling
Faculty advisor: Hyeran Helen Jeon
MANI SANDHU
Investigating the Impact of Different Antihypertensives on Implant Survival Rates
Faculty advisor: Brian Ford
HARRISON SELZNICK
Investigating the Impact of Serum 25(OH) Vitamin D Levels on Implant Survival Rates
Faculty advisor: Brian Ford
EMILY SHEKHTMAN
Predicting Correlation of Preoperative Psychological Condition and Postoperative Pain in Patients Undergoing Extraction of Impacted Third Molars
Faculty advisors: Katherine Theken & Elliot Hersh
JASMINE SHOKRI
Assessing Adolescent Attitudes on the Role of Dentists in Human Papillomavirus and Coronavirus Disease 2019 Vaccinations
Faculty advisor: Katherine France
SAMUEL SUSLAVICH
The Impact of Fisetin on Senescence Markers in Murine Gingival Tissues
Faculty advisor: Esra Sahingur
WINSLOW WANGLEE
Bone Marrow Adipocytes Regulate Osteoclastogenesis via Cxcl12-Cxcr4 Signaling
Faculty advisor: Chider Chen
FELICIA WONG
Analysis of Patient Recall and Return for Care at PCARE
Faculty advisor: Alicia Risner-Bauman
GRACE GONG
Differences in Upper Airway Anatomy between African Americans and Caucasians with Obstructive Sleep Apnea in the US
Faculty advisor: Hyeran Helen Jeon
ANNA-MARIA HADDAD
Debulking of HPV in Oral Cavity through FRIL gum
Faculty advisor: Henry Daniell
ISABELLA ORUP
Demineralization Effect of Orthodontic Brackets and Clear Aligner Therapy on Isolated Teeth: An In Vitro Study
Faculty advisor: Wenjing Yu
BASIC & TRANSLATIONAL SCIENCE HONORS STUDENTS:
BRYANNA BRAVO
Does the Autonomic Nervous System Modulate Pain Perception Induced by Third Molar Extraction?
Faculty advisor: Katherine Theken
DAYOON CHANG
Dissecting the Role of Elastic Mechanics in Regulation of the Oral Cancer Tumor microenvironment
Faculty advisor: Kyle Vining
ALEENA DEFREITAS
Faculty advisor: Kathleen Boesze-Battaglia
ZILIN GUO
Mapping of Herpes Simplex Virus Glycoprotein C Antibodies
Faculty advisor: Gary Cohen
GAURAV GUPTA
Investigating the Effect of Boldine on Paclitaxel-treated Axons in Vitro
Faculty advisor: Katherine Theken
JESSICA HAO
Mapping the Role of Gli1+ Stromal Populations in Head and Neck Squamous Cell Carcinoma
Faculty advisor: Chider Chen
SIHYUN JOUNG
Development and Characterization of the Microstructural, Optical, and Mechanical Properties of Novel 3.5 mol% Yttria-Stabilized Zirconia
Faculty advisor: Yu Zhang
YESUL (ASHLEY) KANG
Acetaldehyde-induced DNA Damage, Fanconi Anemia, and the Role of Oral Microbiome as a Carcinogenic Source
Faculty advisor: Flavia Teles
DAVID KHAYATA
Nanog/Pgc1α is required to promote mitochondrial metabolism for stem cell reprogramming
Faculty advisor: Chider Chen
AJAY KUMAR
Oral Delivery of Proinsulin
Faculty advisor: Henry Daniell
SHERRY SCHNEIDER
Modulation of Aggregatibacter actinomycetemcomitans and Cytolethal distended toxin induced pyroptosis by Synthetic secoisolariciresinol diglucoside (LGM2605) in macrophages
Faculty advisor: Kathleen Boesze-Battaglia
EMON SHAAF
Investigation of novel cell death mechanism for periodontal inflammation in mouse models
Faculty advisor: Kang Ko
TUCKER SPRAYBERRY
Stimulating the Effects of Nocturnal Bruxism on Clear Aligners
Faculty advisor: Myra Laird
KYLER VAN EVERA
Load Bearing Capacity and Translucency of Graded 3D Printed Zirconia
Faculty advisor: Yu Zhang
JESSICA WINARTO
The synergistic anti-tumor effect of metformin and melatonin in oral squamous cell carcinoma (OSCC)
Faculty advisor: Qunzhou Zhang
JONATHAN ZHOU
Examining the role of immunoregulatory oral fibroblasts in experimental periodontitis
Faculty advisor: Kang Ko
CLINICAL AND TRANSLATIONAL RESEARCH HONORS:
MARY PAPANDREAS, D’26
Exploring the concept of a Diagnosis of Exclusion (DOE) and its implications in clinical dentistry.
Faculty Advisors: Michael Glick and Alonso Carrasco-Labra
GRACE D’EGIDIO, D’26
Alyssia Liu , D’28
AADOCR
AADOCR NATIONAL STUDENT RESEARCH GROUP (NSRG) NOMINEE
The AADOCR NSRG is a student run organization and has opened up elections for their officer positions. Alyssia Liu (D ‘28) was selected as Penn Dental Medicine’s nominee for the 2026-2027 cycle and is a candidate for the position of Councilor. We wish Alyssia the best of luck and are excited at the prospect of her representing Penn Dental Medicine at the National Level!
2024 AADOCR STUDENT RESEARCH FELLOWSHIP:
MANUEL ACUNA, D’26
Investigation of Anti-Adhesive Biomaterial in Single-Species and Mixed-Species Oral Biofilm
Faculty Advisor: Geelsu Hwang, PhD
KYUNGJOON PARK, D’25
The Role of NF-kB in Mesenchymal Stem Cells during the Mechanical Force-induced Bone Remodeling
Faculty Advisor: Hyeran Helen Jeon, DDS, MSD, DScD
LAUREN RUDOLPH, D’26
Evaluation of Topical Delivery of Antimicrobial Proteins in Chewing Gums to Neutralize HPV and C. albicans in Oral Cancer Samples
Faculty Advisor: Henry Daniell, PhD
MICHAEL TROKA, D’26
CellStimDL: A Novel Deep Learning Approach to Predict Cytokine Stimulation in Single Cell Omics Data
Faculty Advisor: Dana Graves, DDS, DMSc
“By maintaining a clear vision of your goals and consistently striving for excellence, you’ll set yourself on a path toward a fulfilling and impactful career. Even though the result may not always align with your desire, it will all become a great experience for a lifetime. ”
YU-CHENG CHANG, DDS, MS, DMD
YU-CHENG CHANG, DDS, MS, DMD
Director, Predoctoral Periodontics Program, Associate Professor of Clinical Periodontics Department of Periodontics
Can you tell us a little bit about yourself and your background before coming to Penn Dental?
I grew up in Taiwan, where I received my initial dental education and developed a longstanding aspiration to pursue advanced training abroad in periodontics. After completing a General Practice Residency in Taiwan, I continued my journey at the University of Washington in Seattle as a fellow, where I gained both clinical and research experience. During that period, I was also preparing my applications for periodontal residency programs in the United States. I consider myself incredibly fortunate to have been accepted into the Periodontics program at Penn Dental Medicine, and I’ve remained there ever since—first as a resident and then as a faculty member. It’s hard to believe that over 13 years have passed since I first arrived at Penn!
Can you talk about what your ongoing research projects are?
My current research focuses on clinical trials related to periodontal procedures, particularly in the areas of regeneration and implant dentistry. We’re interested in evaluating various techniques and materials to identify the most effective and evidence-based approaches for patient care. In addition, I’m involved in projects that assess outcomes and risk factors in periodontal treatment, as well as studies that examine our educational methodologies by different approaches including AI . Our goal is to ensure that the strategies we use every day are grounded in solid scientific evidence and continuously updated to reflect the latest advancements in the field.
Can
you describe
the roles that students play in your research process?
Students are integral to our research efforts. They often assist with recruiting patients, organizing data, and performing preliminary analyses. Beyond these essential responsibilities, we encourage students who demonstrate curiosity and passion to take on smaller side
projects, allowing them to explore new questions and develop their own research interests. In this way, students don’t just contribute to our existing work—they also help shape the next generation of research inquiries.
What has been the biggest challenge in your career so far?
Time management has been one of the most persistent challenges throughout my career. At each stage, our priorities shift, making it essential to learn how to allocate our time and energy effectively. While it’s easy to recognize the importance of good time management, it’s much harder to master it. My advice is to continually evaluate your workload, set clear priorities, and be patient with yourself as you strive to find balance. Taking a moment to step back, reflect, and realign your goals can be incredibly helpful.
What advice would you give to a younger version of yourself if you were to restart your dental and research career?
Focus on what truly matters and commit wholeheartedly to your priorities. Work hard, trust your judgment, and do your best without looking back with regret. By maintaining a clear vision of your goals and consistently striving for excellence, you’ll set yourself on a path toward a fulfilling and impactful career. Even though the result may not always align with your desire, it will all become a great experience for a lifetime.
Bisrat Demissie, D’27
NIH Summer Research
HOW DID YOU GET INVOLVED WITH RESEARCH AT PDM?
My research journey was primarily with NIH, where I had the opportunity to work closely with Dr. Pam and my mentor Randy on a stem cell project. Dr. Esra Sahingur from PDM played a huge role in helping me with the application process, guiding me toward this opportunity.
CAN YOU DESCRIBE YOUR RESEARCH?
My research focuses on the role of the HMGB2 protein in enhancing stem cell properties. By comparing HMGB2-transduced cells with control groups, we observed a significant increase in colony formation, suggesting that HMGB2 may play a role in promoting stem cell-like behaviors. Our research could provide insights into tissue regeneration and repair.
DO YOU HAVE ANY FUTURE PLANS WITH YOUR RESEARCH?
I do aim to continue exploring how HMGB2 might contribute to regenerative therapies, particularly within the oral and maxillofacial area.
WHAT DO YOU THINK IS THE MOST IMPORTANT QUALITY OF AN EFFECTIVE RESEARCHER?
For me I believe the most important and driving quality is curiosity—being genuinely interested in asking questions and pursuing the unknown. This, paired with hard work and persistence will make an effective researcher.
FUN FACT?
I’m into nature photography and enjoy capturing the beauty of the outdoors during hiking trips whenever I get the chance to hike.
“For me I believe the most important and driving quality is curiosity—being genuinely interested in asking questions and pursuing the unknown.”
BISRAT DEMISSIE, D’27
HYERAN HELEN JEON, DDS, MSD, DSCD
Assistant Professor, Department of Orthodontics
Can you tell us a little bit about yourself and your background before coming to Penn Dental?
I am Hyeran Helen Jeon, an Assistant professor in the Department of Orthodontics at Penn Dental Medicine. I received my DDS and completed a Periodontics residency in South Korea. After three years as an associate in private practice, I joined Penn for an Orthodontics residency in 2011. During my Master of Science in Oral Biology (MSOB), I decided to deepen/expand my research and transitioned to the Doctor of Science in Dentistry (DScD) program, where I developed expertise in designing experiments, writing proposals and manuscripts, critically reviewing papers, and presenting my research findings at domestic/international conferences. It was an invaluable five-year journey that shaped my career as a clinician-scientist. Since 2016, I have been a full-time faculty member, teaching and mentoring both predoctoral and postdoctoral students in their research. I also practice every Tuesday at Penn Dental Family Practice at Locust Walk. Outside of PDM, I enjoy working out, running, traveling, and reading.
Can
you talk about what your ongoing
research projects are?
For basic science, I am investigating “soft and hard tissue remodeling in response to the mechanical force” using the mouse maxillary expansion models. Maxillary expansion is a common orthodontic procedure to address maxillary transverse deficiencies, yet the underlying mechanisms are not fully understood. My research focuses on the responses of mesenchymal stem cells in the midpalatal sutures during maxillary expansion. We have completed an initial project examining the impact of aging on tissue remodeling during maxillary expansion. In our second project, we are exploring the roles of NF-kB in mesenchymal stem cells during mechanical force-induced tissue remodeling.
I also lead several clinical projects. The first compares treatment outcomes of fixed functional appliances versus dental camouflage in Class II growing patients, focusing on skeletal, dental, soft tissue, and airway changes. In the second, I am investigating treatment outcomes of miniimplant-supported maxillary expansion. While mini-implants enhance skeletal anchorage for mature patients, success rates are not 100%, and the factors influencing success remain unclear. The third project focuses on deep bite correction with clear aligners, which presents challenges in aligner-based treatment.
Can you describe the roles that students play in your research process?
Before beginning experiments, students typically conduct a thorough literature review of their topics to understand the current research landscape in their field. I particularly enjoy discussing experimental plans with my students and hearing their creative, out-of-the-box ideas!
In basic science, our students engage in a variety of research activities, including genotyping, microCT imaging, H&E, immunofluorescence, and immunohistochemistry staining. In clinical projects, they measure anatomical landmarks using CBCT data from deidentified samples. Students conduct experiments, analyze data, and present their findings at PDM Research Day and AADOCR annual meetings.
“Time management has been challenging as a full-time faculty member, with three primary responsibilities: research, teaching/mentoring, and service. Balancing these roles is not easy, but it’s incredibly rewarding to see my students present their findings at national conferences and receive well-deserved recognition for their work.”
HYERAN HELEN JEON, DDS, MSD, DSCD
What has been the biggest challenge in your career so far?
Time management has been challenging as a full-time faculty member, with three primary responsibilities: research, teaching/ mentoring, and service. Balancing these roles is not easy, but it’s incredibly rewarding to see my students present their findings at national conferences and receive welldeserved recognition for their work. This is one of the most fulfilling aspects of staying in academia.
What advice would you give to a younger version of yourself if you were to restart your dental and research career?
I would advise getting involved in a wide range of research projects— basic, clinical and translational—during dental school. It’s also valuable to gain experience in taking a project from start to finish, including writing proposals and papers as early as possible. Completing the entire process helps you develop the ability to see the big picture. Additionally, I would recommend seeking out leadership opportunities as they can be instrumental in professional growth.
Marvin Min, D’27 Summer Research Program
HOW DID YOU GET INVOLVED WITH RESEARCH AT PDM?
I reached out to Dr Katherine Theken after reading through the various research projects being led by faculty and hers stood out to me as it aligned with my own research interests. So, I emailed her, and she took me on board!
CAN YOU DESCRIBE YOUR RESEARCH?
My research project investigates pharmacogenetics and its implications on analgesia therapy following dental procedures like third molar extraction and dental implants. More specifically, I am studying the effects of single nucleotide polymorphisms (SNPs) in the PTGS1 and PTGS2 genes which code for cyclooxygenase-1 and cyclooxygenase-2 enzymes.
WHAT MADE YOU DECIDE TO PARTICIPATE IN THE SUMMER RESEARCH PROGRAM?
One thing I wanted to do differently in dental school from undergrad was to participate in research. Not only was my introduction to research at PDM a pleasant and welcoming experience due to Dr Theken, but I learnt that the school has a strong emphasis on student involvement in research, so naturally it seemed like the next step for me as I felt like it allowed me to utilize all the resources dedicated to research available to all PDM students.
DO YOU HAVE ANY FUTURE PLANS WITH YOUR RESEARCH?
Regarding my work at Theken Lab, I will be continuing to look into more SNPs and presenting my findings at the AADOCR meeting next year. I applied for the Clinical Research Honors Program to learn more about designing and executing clinical trials which I hopefully will hear back from soon.
WHAT DO YOU THINK IS THE MOST IMPORTANT QUALITY OF AN EFFECTIVE RESEARCHER?
I think in my experience prioritizing literature review has been vital. It gives a researcher clear guidelines and parameters to base their study around. Having a clear direction can minimize a lot of roadblocks and dead ends that happen a lot when doing research.
FUN FACT?
I started research before the summer before D1 because I was just so bored at home, but I realized quickly that it gave me major gunner vibes when I first met my classmates.
Chrissie (Nadasinee) Jaruchotiratanasakul, DDS
Resident in Endodontics & Doctor of Science in Dentistry
Can you tell us a bit about yourself and your background before coming to Penn Dental Medicine?
Hi there! I graduated with my DDS from Mahidol University, Thailand in 2021, and started my career there as a lecturer. I’m part of a team in the Department of Operative Dentistry and Endodontics—a role I’m absolutely passionate about. It’s been such a rewarding journey so far, but I quickly realized that being a great lecturer required me to level up my qualifications. That’s when I set my sights on pursuing advanced studies abroad.
The journey wasn’t easy, but it was exciting! I spent two years building my portfolio with academic experiences, research projects, and teaching practice, all to make myself stand out to international universities. With lots of guidance from amazing professors, I found my dream destination: the University of Pennsylvania. It’s one of the top institutions in the world for Endodontics, a true pioneer in cutting-edge tools and innovative treatments. Plus, being an Ivy League school, it felt like the perfect match for my ambitions.
Fast forward to application time—I gave it my all, and within a few months of interviews and preparation, I was thrilled to be accepted into their Doctor of Science in Dentistry and Endodontics Residency Program! It’s a five-year program that started in 2023, and I couldn’t be more excited about the opportunities and learning experiences ahead.
What made you choose Penn Dental Medicine for your postdoc training?
It was in 2022 and I had not flown overseas in three years because of COVID-19 restrictions. When the travel guidelines were eased, the primary destination in my thoughts became Penn Dental Medicine. I attended a microsurgery training course at the University of Pennsylvania, where I met the school members whom I have religiously examined their publications. The complete enjoyment became like meeting celebrities; the authors of the book “Microsurgery in Endodontics,” especially Dr. Kim and Dr. Kratchman, are no less than brilliant in their problematic strategies and analytical views. During my visit, the lectures covered microsurgical endodontics, evidence-based dentistry, and intentional replantation. Seeing a lot of big names from the Penn Endo family in person really sparked my desire to be a part of this program. Those lectures and microsurgical training showed my aspiration to become one of all their college students.
Can you talk about what your ongoing research projects are?
My research focuses on the innovative application of nanozymes in endodontics to revolutionize root canal treatment by enhancing its efficiency and precision. Nanozymes, which mimic natural enzymes, catalyze hydrogen peroxide to generate reactive oxygen species (ROS), providing a dual mechanism of action—biofilm disruption and bacterial eradication. By integrating nanozyme technology into microrobotic platforms, these magnetically actuated microrobots navigate the complex and confined anatomy of root canals with precision, ensuring targeted disinfection even in hard-to-reach apical regions. This approach combines advanced navigation, catalytic action, and adaptability to optimize root canal disinfection, addressing the limitations of conventional therapies
while significantly improving therapeutic outcomes. My work aims to harness these advancements to deliver a more effective, efficient, and minimally invasive solution to endodontic challenges.
How
did
you get involved in Research at Penn Dental Medicine?
I’m part of the Doctor of Science in Dentistry program at Penn Dental Medicine, where research plays a significant role in our academic journey. My interest in research stems from my aspirations to build a career as a clinician-scientist in academia. During my time here, I started with lab rotations in the Levy building, where I became fascinated by the innovative work happening in Dr. Michel Koo’s biofilm lab. What drew me in was the collaborative environment—engineers, roboticists, microbiologists, veterinarians, and dentists all working together to tackle important challenges in biofilm research. It’s an inspiring place that aligns perfectly with my passion for advancing dental science.
What advice would you give to a younger version of yourself if you were to restart your dental and research career?
I wouldn’t change anything about my dental and research career because every experience, challenge, and success has shaped me into the person I am today. The support from friends, family, and mentors has been invaluable, and they’ve been a big part of my journey so far. If I could give my younger self one piece of advice, it would be to focus on one thing at a time. Even though multitasking can be helpful, some tasks are best done when you take the time to rest and give them your full attention. I’d also remind myself to prioritize “me” time and trust in the amazing support system I have—there’s no need to worry too much about the future; things will fall into place.
Amy Lin, DMD Resident in Pediatrics
Can you tell us a bit about yourself and your background before coming to Penn Dental Medicine?
I majored in biochemistry and minored in chemistry, while I ran cross country & track for Case Western Reserve University. I earned my dental degree from the University of Illinois Chicago. In my 3rd year of dental school, I started treating pediatric patients once a week. I always thought I would be Amy Lin, the dentist, and never dreamt of specializing. While I liked working with adults, I quickly learned that my most enjoyable days at the clinic were when I worked with kids. My goal is to make all children comfortable visiting the dentist and help them receive proper dental care from an early age to prevent future emergencies. Pediatric dentistry would give me the opportunity to make a long-lasting difference in a patient’s life by encouraging good dental habits at a young age.
What made you choose Penn Dental Medicine for your postdoc training?
I chose Penn Dental Medicine for my postdoc training because I valued how it was a hybrid program of being at an academic institution and hospital. For me, I wanted a robust and well-rounded program to help me become an excellent pediatric dentist. Penn Dental Medicine was the place where I felt most comfortable and saw myself calling “home” for the next few years. The faculty, attendings, and staff are spectacular. The cases and experiences at Penn/Children’s Hospital of Philadelphia are one of a kind as we are honored to treat people across the country and even worldwide.
Can you talk about what your ongoing research projects are?
Caries in children is a prevalent oral disease that can have serious impacts on a child’s overall wellbeing and the future of
their health. Diet is a critical contributing factor. Excessive intake of dietary carbohydrates can increase the presence of acid-producing microorganisms in dental plaque, leading to the formation of carious lesions. The ketogenic diet, which is sometimes used to manage seizures, restricts carbohydrate consumption. There is limited research on its effects on the oral microbiome. This research project seeks to evaluate changes in the microbial composition of dental plaque resulting from the ketogenic diet. Patients scheduled to begin this diet at the ketogenic clinic at CHOP will be screened for eligibility, and dental plaque samples will be collected from consented participants before starting the diet and then at 3, 6, 12, and 18 months afterward. These samples will undergo shotgun metagenomic sequencing to assess microbiota differences.
How
did you get involved in Research at Penn
Dental Medicine?
All Pediatric residents are involved in some sort of research. Since we are part time at CHOP, we are fortunate enough to have access to a unique population (ketogenic diet). I was lucky enough to get in touch with great mentors like Dr. Yuan Liu, Dr. Evlambia (Betty) Hajishengallis , Dr. Alina O’Brien and Dr. Lauren Yap who have provided constructive feedback, advice, and guidance for my IRB and more. I am also thankful to all the dental students who are willing to meet and help with the project in any capacity they can.
What
has
been the biggest challenge in your career/research so far?
One of my biggest challenges with research during residency is balancing the clinical responsibilities with the work that comes with research. As a resident, we have long hours balancing our different responsibilities: administrative work, being
POSTDOC RESIDENT Q&A
I would say keep saying “YES” to opportunities for you never know which doors they may open.
AMY LIN, DMD
on call for CHOP, our classes. Ultimately, our priority is providing and prioritizing the best patient care, especially when they’re in our clinic. Luckily, I have great mentors to help and reach out to.
What advice would you give to a younger version of yourself if you were to restart your dental and research career?
I would say keep saying “YES” to opportunities for you never know which doors they may open. The option to say “no” is always available in the future, if things are not working out the way you imagined. Everything always happens for a reason, but you may miss out on opportunities if you don’t “raise your hand.” I would not be here at Penn today if it were not for my support system: my family, friends, peers, mentors, and teachers who continue to help open many doors for me.
2024 DMD STUDENT PUBLICATIONS
ZHAOXU CHEN, D’27 and JONATHAN ZHOU, D’26
Chen Z, Debnath R, Chikelu I, Zhou JX, Ko KI. Primed inflammatory response by fibroblast subset is necessary for proper oral and cutaneous wound healing. Mol Oral Microbiol. 2024 Jun;39(3):113-124. doi: 10.1111/omi.12442
JESSICA HAO, C’23, D’26
Hao J, Chen C, Pavelic K, Ozer F. ZIF-8 as a pHResponsive Nanoplatform for 5-Fluorouracil Delivery in the Chemotherapy of Oral Squamous Cell Carcinoma. Int J Mol Sci. 2024 Aug 27;25(17):9292. doi: 10.3390/ijms25179292. PMID: 39273239; PMCID: PMC11394749.
Liang XG, Hoang K, Meyerink BL, Kc P, Paraiso K, Wang L, Jones IR, Zhang Y, Katzman S, Finn TS, Tsyporin J, Qu F, Chen Z, Visel A, Kriegstein A, Shen Y, Pilaz LJ, Chen B. A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex. Proc Natl Acad Sci USA 2024 May 14;121(20):e2321711121. doi: 10.1073/pnas.2321711121. Epub 2024 May 7. PMID: 38713624; PMCID: PMC11098099.
CHRISTY QIAN, D’26
Liao A, Qian C, Abdi S, Yee P, Cursain SM, Condron N, Condron B. Population parameters of Drosophila larval cooperative foraging. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2024 Apr 10. doi: 10.1007/s00359024-01701-w. Epub ahead of print. PMID: 38594346.
SHIVANI IYER, D’26 and RIYA PATEL, D’26
Mergler BD, Patel RU, Iyer S, Chae RS, Gluch JI, Mergler RJ, Vail EA, Duffy CC. Challenges of Motherhood for Anesthesiologists: A Scoping Review. A A Pract. 2024 Dec 5;18(12):e01876. doi: 10.1213/XAA.0000000000001876. PMID: 39636038.
SRIGHANA NADELLA, C’22, D’25, ML’26
Nadella S, Wang TT, Gross AJ, Wang S. Prescription Drug Monitoring Program Mandates: Current Landscape and Legal Considerations for Oral and Maxillofacial Surgery. J Oral Maxillofac Surg. 2024 Apr;82(4):383-385. doi: 10.1016/j.joms.2023.11.020. PMID: 38565282.
JESSICA HAO, C’23, D’26
Ozer F, Batu Eken Z, Hao J, Tuloglu N, Blatz MB. Effect of Immediate Dentin Sealing on the Bonding Performance of Indirect Restorations: A Systematic Review. Biomimetics (Basel). 2024 Mar 17;9(3):182. doi: 10.3390/biomimetics9030182. PMID: 38534867; PMCID: PMC10968373.
JESSICA TAN, C’22, D’25 and JESSICA HAO, C’23, D’26
Tan J, Hao J, Vann D, Pavelić K, Ozer F. Effect of Zeolite Incorporation on the Ion Release Properties of Silver-Reinforced Glass Ionomer Cement. Biomimetics (Basel). 2024 Jun 17;9(6):365. doi: 10.3390/ biomimetics9060365. PMID: 38921245; PMCID: PMC11202068.
SRIGHANA NADELLA, C’22, D’25, ML’26
Wang TT, Nadella S, Sakano T, Wang S, Burris BJ. The Rise of GlucagonLike Peptide 1 Agonists: Considerations for Oral and Maxillofacial Surgery. J Oral Maxillofac Surg. 2024 Aug;82(8):888-890. doi: 10.1016/j.joms.2024.04.005. Epub 2024 Apr 16. PMID: 38688461.
SRIGHANA NADELLA, C’22, D’25, ML’26
Wong K, Nadella S, Mupparapu M, Sethna C. Preventative dental practices and cardiometabolic health in adolescents. Quintessence Int. 2024 Jul 17;0(0):0. doi: 10.3290/j. qi.b5586051. Epub ahead of print. PMID: 39016671.
SRIGHANA NADELLA, C’22, D’25, ML’26
Wong K, Nadella S, Mupparapu M, Sethna C. Dental caries and adolescent cardiometabolic health from the National Health and Nutrition Examination Survey (NHANES). Nutr Metab Cardiovasc Dis. 2024 Sep 10:S0939-4753(24)00355-7. doi: 10.1016/j. numecd.2024.09.006. Epub ahead of print. PMID: 39438228.
JOHN BUTTON, D’25
Urquhart, O., Matanhire-Zihanzu, C.N., Kulkarni, R., Parrado, E.A., Aljarahi, H., Bhosale, A.S., Braimoh, O.B., Button, J., Chifamba, T., Emmanuel, A.T., Gatarayiha, A., Kohler, I.V., Martins-Pfeifer, C.C., Ojukwu, B.T., Robbins, M., Sofola, O., Taiwo, O.O., Uti, O., Makino, Y., Glick, M., & Carrasco-Labra, A. (2024). Oral Health Policy and Research Capacity: Perspectives From Dental Schools in Africa. International dental journal.
2024 STUDENT PRESENTATIONS AT CONFERENCES
LOULIA ALAWA, D’25
Diabetes Reversal and the Subgingival Microbiota. 2024 Greater New York Dental Meeting, November 29-December 4. New York City, New York.
MANUEL ACUNA, D’26
Investigation of Anti-Adhesive Biomaterial in Single-Species and Mixed-Species Oral Biofilm. 2024 IADR/AADOCR/CADR General Session & Exhibition, March 13-16, 2024. New Orleans, Louisiana.
PHILIP DELISI, D’26
Short-Term Outcome of Teeth Undergoing Intentional Implantation. 2024 Greater New York Dental Meeting, November 29-December 4. New York City, New York. Short-Term Outcome of Teeth Undergoing Intentional Implantation. 2024 Greater New York Dental Meeting, November 29-December 4. New York City, New York.
BACENT ELBANNA, D’25
Diabetes Reversal and the Subgingival Microbiota. 2024 Greater New York Dental Meeting, November 29-December 4. New York City, New York.
STEVEN FREDEEN, D’25
Experimental Validations of VFEM Models for PVZ and PVLD Crowns. 2024 IADR/AADOCR/CADR General Session & Exhibition, March 13-16, 2024. New Orleans, Louisiana
LINDSAY FISHER, D’26
Effects of Aging on Mechanical Force-Induced Bone Remodeling: MicroCT Analysis. 2024 IADR/AADOCR/CADR General Session & Exhibition, March 13-16, 2024. New Orleans, Louisiana.
ANGELINA GE, D’26
Adolescent Receptiveness to Dentist Involvement in COVID-19 and HPV Vaccination. 2024 IADR/AADOCR/CADR General Session & Exhibition, March 13-16, 2024. New Orleans, Louisiana
SARAH GREENBERG, D’26
State Policies and Population Factors in Dental Vaccination Involvement. 2024 IADR/AADOCR/CADR General Session & Exhibition, March 13-16, 2024. New Orleans, Louisiana.
SIMRAN GREWAL, D’25
Effects of Exosomes Released by GMSC-derived NCSC-like Cells on Macrophages. 2024 IADR/AADOCR/CADR General Session & Exhibition, March 13-16, 2024. New Orleans, Louisiana.
SARA HA, D’25
Histologic Analysis of Bone Remodeling during Maxillary Expansion: Young and Middle-Aged Mice. 2024 IADR/AADOCR/CADR General Session & Exhibition, March 13-16, 2024. New Orleans, Louisiana.
JESSICA HAO, D’26
ZIF-8 as pH-responsive 5-fluorouracil Carrier Against Oral Squamous Cell Carcinoma. 2024 IADR/AADOCR/CADR General Session & Exhibition, March 13-16, 2024. New Orleans, Louisiana.
JENNA HAHN, D’25
Short-Term Outcome of Teeth Undergoing Intentional Implantation. 2024 Greater New York Dental Meeting, November 29-December 4. New York City, New York.
NINA IRADI, D’25
Diurnal Rhythm is Associated with Opioid Use After Third-Molar Extraction. 2024 IADR/AADOCR/CADR General Session & Exhibition, March 13-16, 2024. New Orleans, Louisiana.
CHARLOTTE LENES, D’25
Investigating the Role of Pro–inflammatory Fibroblasts in Periodontitis and Peri–implantitis. 2024 IADR/AADOCR/CADR General Session & Exhibition, March 13-16, 2024. New Orleans, Louisiana.
DREW MACELROY, D’25
Modulation of A. Actinomycetemcomitans (Aa) and Cdt Induced Inflammation in Macrophages. 2024 IADR/AADOCR/CADR General Session & Exhibition, March 13-16, 2024. New Orleans, Louisiana.
SRIGHANA NADELLA, D’25
Do Infectious Disease Consultations Improve Outcomes for Surgical Management of MRONJ? 106th AAOMS Annual Meeting, September 9-14, 2024. Orlando, Florida.
RYAN NOSEWORTHY, D’25
Probing Interfacial Strength and Crack Resistance of Novel CompositionGradient Zirconia. 2024 IADR/AADOCR/CADR General Session & Exhibition, March 13-16, 2024. New Orleans, Louisiana.
TENY ODAIMI, D’25
3D Printed Polymers in Dentistry and their Clinical Applications. 2024 IADR/AADOCR/CADR General Session & Exhibition, March 13-16, 2024. New Orleans, Louisiana.
LAUREN RUDOLPH, D’25
Dextranase, Mutanase, and Lipase Chewing Gum Enzymatic Biofilm Suppression. IADR/AADOCR/CADR General Session & Exhibition, March 13-16, 2024. New Orleans, Louisiana.
ARJUN SANDHU, D’25
Oral Health Quality of Life in People with HIV and Depression. 2024 IADR/AADOCR/CADR General Session & Exhibition, March 13-16, 2024. New Orleans, Louisiana.
STEFANIE WYSZKOWSKI, D’26
Comparative Analysis of Full-Arch Abutment-Level Implant Impressions. 2024 IADR/AADOCR/CADR General Session & Exhibition, March 13-16, 2024. New Orleans, Louisiana.
YOUSSEF YOUSSEF
Diabetes Reversal and the Subgingival Microbiota. 2024 Greater New York Dental Meeting, November 29-December 4. New York City, New York.
STUDENT INTERVIEW
John
Button, D’26
Summer Research Program & Independent Research
HOW DID YOU GET INVOLVED WITH RESEARCH AT PDM?
Before coming to Penn, a friend of mine, Dr. Craig Holliday, an oral and maxillofacial surgery resident at Tufts University, recommended that I contact Dr. Brian Ford, Assistant Professor of Oral and Maxillofacial Surgery/Pharmacology at PDM, to start a research project. After reading some of his recent articles, I met with Dr. Ford during orientation week and devised a plan to participate in the Summer Research Program investigating the inflammatory complications associated with sinus lifts. Later that year, an opportunity also arose for me to research a long-standing personal interest of mine: a neglected disease called noma. Noma is a devastating oro-facial gangrene which predominantly affects malnourished children across Africa.
CAN YOU DESCRIBE YOUR RESEARCH?
My research can be broken into two main arms: that which I conduct with Dr. Ford on dentoalveolar surgery at the Philadelphia VA Hospital and the independent epidemiology research I conduct on noma. At the VA, I ran a retrospective chart review of all the patients who underwent sinus augmentation surgery from 2012 to 2023. I presented the findings of this work at the Annual Meeting of the American Association of Oral and Maxillofacial Surgeons (AAOMS) in September 2024. For my work on noma, I conducted a scoping literature review on the disease from 2000 to 2024 to identify and quantify where, geospatially, cases occur. I am currently pursuing a Master of Science in Oral and Population Health
(MOPH) along with my dental degree, where a formal research project on noma and its risk factors will serve as the basis for my thesis.
WHAT MADE YOU DECIDE TO PARTICIPATE IN THE SUMMER RESEARCH PROGRAM?
As an undergraduate, I participated in two summer research programs—one through the Jonathan M. Tisch College for Civic Life and the other through the Institute for Research on Learning and Instruction, both at Tufts University. This work introduced me to the translational and transformative power of research; since then, I have felt tremendous motivation to pursue research as an avenue by which I could influence public health for the better. When I heard about PDM’s having a similar program, I leapt at the opportunity. I particularly appreciated that the Summer Research Program allowed me the freedom to pursue research during the summer break we are afforded between our first and second years.
DO YOU HAVE ANY FUTURE PLANS WITH YOUR RESEARCH?
I have always wanted to work with Médecins Sans Frontières (Doctors Without Borders). My epidemiology research on noma, in particular, has deepened my understanding of global oral health and solidified my interest in the space. Currently, I sit on the advisory committee of the International Noma Network, a global research consortium which holds monthly webinars on noma and advocates for greater awareness of the disease. After dental school, I will be pursuing a career
in oral and maxillofacial surgery where I hope to integrate my research interest in dentoalveolar surgery with my burgeoning interest in surgical reconstruction for people who have suffered with noma. The research I started at Penn has already introduced me to research partners and collaborators across the world—people with whom I know I will continue to work throughout my career.
WHAT DO YOU THINK IS THE MOST IMPORTANT QUALITY OF AN EFFECTIVE RESEARCHER?
I think that an effective researcher must be an effective communicator. As important as research articles are for advancing science, in some ways, I believe they are given more importance than they merit. A modern researcher needs to be someone who communicates the findings of their work not just within their discipline but with the broader community writ large—the general public. As clinician-scientists, we have a duty to make our research accessible to those whom it affects. To that end, I am a strong advocate for the inclusion of plain-language summaries in research papers, to increase accessibility. As medical misinformation amongst patients increases, the imperative to communicate research effectively too must increase.
FUN FACT?
I am a PADI-certified SCUBA diver! I have always loved swimming and water sports (I played water polo in college), so getting my SCUBA license was on my bucket list from a young age.
If you are interested in learning more about noma or collaborating on a project, please do not hesitate to contact me: jbutton@upenn.edu
