AAVLD 2020- High Containment

High Containment AAVLD 2020 ―

American Association of Veterinary Laboratory Diagnosticians Annual Meeting / Conference

High Containment

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National Bio and Agro Defense Facility Manhattan, Kansas Client: United States Department of Homeland Security Size: 708,000 square feet Completion Date: 2021 Biosafety Levels: ACL-2, BSL-2, ACL-3, BSL-3, BSL-3Ag, BSL-4, BSL-4 Large Animal The NBAF is an integrated foreign animal and zoonotic disease research, development, and testing facility which will enhance the nation's capabilities to ensure agricultural animal health.

The facility provides a full range of research space types and capabilities for agricultural pathogen study never before seen in the United States. As the nation's first BSL-4 facility capable of handling in vivo research with large animal models, NBAF will allow researchers to study some of the world's most destructive newly emerging diseases, such as the Nipah and Hendra viruses. Meanwhile the BSL-3Ag and BSL-3 portions of the building will study the more common foreign animal and zoonotic diseases that continue to threaten public health and agricultural economies around the world.

― WHAT IT IS

A high containment facility of unprecedented scope that will allow researchers to study foreign animal and emerging diseases in a state-of-the-art facility designed to the highest standards of biosafety and biosecurity.

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The United States' first facility capable of in vivo studies with large livestock in a BSL-4 environment. This will become the new home for research of foreign animal disease in the United States. The NBAF will replace the aging Plum Island Animal Disease Center off the coast of New York.

The NBAF's effluent Decontamination System consisting of eleven 7,500 gallon tanks is the current record holder for "Largest Effluent Decontamination System in the world."

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― WHAT MAKES IT COOL

As a key national asset, NBAF will become the international icon for biocontainment around the world.

The NBAF includes 100% N+1 redundancy on all building systems with the capability to remain off the power grid for up to 14 days without outside power and 24 hours without off-site domestic water.

“The NBAF will be a key component in our joint effort with USDA to advance research, which is critical to the security of our nation’s food supply and agricultural economy."

Under Secretary Dr. Reginald Brothers, Department of Homeland Security, Science and Technology Directorate

To achieve a more efficient work day, the NBAF includes a lunch room inside the containment area of the building. This is made possible by carefully integrating the building design with protocols required both prior to exiting higher risk BSL-3 areas and at the entry to the lunch room. The lunch room is visible from the lobby and connects visually with the informal break area outside containment with a view out through the front of the building.

Clockwise from Top Right: Lobby, BSL-3 Laboratory, Main Entrance, BSL-4 Necropsy

The only high containment facility in the world designed to be tornado-resistant up to an EF-5 tornado and winds of 230 mph.

Global Health Research Complex College Station, Texas Client: Texas A&M University Size: 107,000 square feet Completion Date: 2020 Biosafety Levels: ACL-2, BSL-2, ABSL-2, ACL-3, BSL-3, ABSL-3, BSL-3Ag The GHRC's research programs are centered around the prevention of emerging and infectious diseases affecting both livestock and humans, bioterrorism countermeasures, food safety, and disease diagnostics and detection. It is one of the few research facilities in the world that has dedicated training capabilities for both BSL-3Ag large animal and BSL-3 laboratory research protocols and practices. It is meant to be a catalyst to fuel synergistic connections between the University's biomedical, veterinary, engineering, and health programs.

― WHAT IT IS

A modern, cuttingedge biocontainment facility to study high consequence infectious diseases.

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Global Health Research Complex

― WHAT MAKES IT COOL

One of only a very small handful of modern BSL-3Ag facilities in North America. The GHRC is designed to allow researchers to works with a wide range of species, from mice to bison.

“This facility is really a crown jewel, not just for the Division of Research for Texas A&M University and the state of Texas, but really a very important asset for the nation and for our global partners in addressing disease." -Dr. Mark Barteau, Vice President for Research, Texas A&M University

Global Health Research Complex

Research programs are centered on the prevention of emerging and infectious diseases affecting both livestock and humans, bioterrorism countermeasures, food safety, and disease diagnostics and detection.

This complex is a catalyst to fuel synergistic connections between the University’s biomedical, veterinary, engineering, and health programs.

National Biodefense Analysis and Countermeasures Center Fort Detrick, Maryland Client: United States Department of Homeland Security Size: 160,000 square feet Completion Date: 2010 Biosafety Levels: BSL-2, ABSL-2, BSL-3, ABSL-3, BSL-4, ABSL-4 The NBACC was the first new building project for a newly created department in the President's cabinet, the Department of Homeland Security. Created to better integrate efforts across other government agencies, this new facility was designed for collaboration with the FBI and others in the effort to analyze evidence from any future bioterrorism event. The facility also provides research space for study and development of vaccines and treatment countermeasures for select agents that may be weaponized. The NBACC is part of a new biodefense quad on Fort Detrick comprised of sister facilities operated by the NIH and the U.S. Army.

Awards: Mega Project Excellence in Construction Award, Associated Building and Contractors- Metro Washington and Virginia Chapters, 2009

― WHAT IT IS

Home to the leading Federal agency for bioforensic analysis from investigations of biocrime and terrorism.

“Facility design is brilliant, knocked my socks off.”

Maureen McCarthy, Director, Office of Research and Development, Department of Homeland Security

The facility includes meeting spaces designed to Sensitive Compartmented Information Facility (SCIF) standards, a requirement for processing classified information.

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National Biodefense Analysis and Countermeasures Center

― WHAT MAKES IT COOL

Researchers here developed advanced DNA sequencing methods to determine the identity of a 4,000 year old Egyptian mummified head, solving a mystery dating back to its discovery in 1915.

↑ Large windows give laboratory staff a view of the outdoors. Even researchers in the BSL-4 areas enjoy a view to the natural landscape outside.

→ Created quietly a few months after the anthrax attacks, the NBACC was intended to be the principal outpost to handle agents such as Anthrax and Ebola virus.

← The NBACC is the first stop for collected evidence from a suspected bioterrorism event in the United States. In 2013, NBACC confirmed the presence of Ricin in letters mailed to government officials.

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Galveston National Laboratory

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Galveston National Laboratory Galveston, Texas Client: The University of Texas Medical Branch at Galveston Size: 194,000 square feet Completion Date: 2008 Biosafety Levels: ACL-2, BSL-2, ABSL-2, ACL-3, BSL-3, ABSL-3, BSL-4, ABSL-4 The GNL was funded by the National Institutes of Health as one of two national biocontainment laboratories following the attacks of 9/11. Researchers at the GNL work on therapeutics, vaccines, and diagnostics to combat

― WHAT IT IS

emerging infectious diseases. The facility includes a full gamut of laboratory spaces and capabilities for the study of high consequence diseases affecting human health. Once construction was complete, the GNL was commissioned and approved to start work with BSL-4 pathogens in less than two years, a feat almost unheard of for a facility of this complexity.

This prominent biocontainment research facility provides much needed high containment and BSL-4 laboratory space for researchers from around the United States.

UTMB has been on the forefront of fighting infectious disease since the early 20th Century, and the GNL continues that tradition as a national resource comprising an important part of our country’s research infrastructure.

This facility was the first BSL-4/ABSL-4 in a high rise building.

It was designed for hurricane resistance, successfully weathering several major storms since its completion.

Located in the heart of a busy academic campus, security requirements were successfully met without a perimeter fence.

Researchers at the GNL developed the first aerosol vaccine shown to neutralize the Ebola virus in non-human primates.

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Galveston National Laboratory

― WHAT MAKES IT COOL

Work inside the facility focuses on developing therapies, vaccines, and diagnostic tests for microbes that could be used by bioterrorists.

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Galveston National Laboratory

Robert E. Shope BSL-4 Laboratory Galveston, Texas Client: The University of Texas Medical Branch at Galveston Size: 12,000 square feet Completion Date: 2003 Biosafety Levels: BSL-4, ABSL-4 The Robert E. Shope BSL-4 Laboratory was the predecessor to the Galveston National Laboratory, and is connected to the GNL via sky bridge. The Shope Lab was born from UTMB's reputation as a recognized center for the study of tropical and emerging diseases, as the logical next step to advance the level of research possible. As the first BSL-4 laboratory built on an academic campus, the funding and approval of the Shope Lab was a unique achievement at the time. The facility took on a whole new importance following the attacks of 9/11 as the push to study countermeasures for bioterrorism suddenly became a national priority.

― WHAT IT IS

A BSL-4 laboratory facility designed for operational flexibility to study the world's most harmful pathogens.

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This project includes significant funding from the National Institutes of Health (NIH).

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Robert E. Shope BSL-4 Laboratory

Clockwise from Top Left: Researchers inside the chemical shower, Researchers prepping their suits prior to entry to the BSL-4, Researchers handing off a sample.

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← Redundant MEP systems, intricate waste systems, and a high level of building security result in an extremely complex and concentrated lab space.

↓ The Shope lab is an addition to a historic building on campus, and was required to undergo review by the Texas Historical Commission.

― WHAT MAKES IT COOL

The Shope Lab was the first of the modern generation of BSL4 Labs in the United States.

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Texas A&M Veterinary Medical Diagnostic Laboratory (TVMDL) College Station, Texas Client: The Texas A&M University System Size: 93,000 square feet Completion Date: 2016 Biosafety Levels: BSL-2, BSL-3, ABSL-3 Awards: Award for Project Excellence (APEX), General Contractor of Houston, 2019

1 of 3 projects designed for TVMDL; repeat work from a relationship dating back to 2009.

The TVMDL has received some of the planet's largest mammals; elephants and giraffes have been brought in from zoos nearby Houston and Dallas on more than one occasion.

― WHAT IT IS

The State of Texas's front line of defense for rapidly identifying the outbreak of a high-consequence agricultural pathogen.

TexasA&MVeterinaryMedicalDiagnosticLaboratory(TVMDL)

― WHAT MAKES IT COOL

As one of the highest volume veterinary labs in the nation, case loads average more than 200,000 per year.

"A remarkable facility, by far the best vet diagnostic lab in the country.

Others may try to build better, but it will be very difficult to do so."

- Chancellor John Sharp

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This building serves as a replacement for the aging TVMDL facility on the Texas A&M University Campus. The facility addresses any potential high-consequence disease outbreak which could result in economic losses of billions of dollars and trade restrictions that could halt exports of Texas agricultural products. As one of the highest volume veterinary laboratories in the nation, they average more than 200,000 cases each year. Routine testing serves as the national backbone of a state, national, and global surveillance system, and supports animal health as well as trade, exports, and the economic structure of agriculture in Texas.

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Zilkha Neurogenetic Institute Los Angeles, California Client: University of Southern California Size: 126,000 square feet Completion Date: 2013 Biosafety Levels: BSL-2, BSL-3, ABSL-3 The Zilkha Neurogenetic Institute is located on the Health Sciences Campus of the University of Southern California, northeast of downtown Los Angeles.

This building initiates a new design direction for the Keck School of Medicine. Phase I of this new Research Quadrangle, linking the academic and clinical sections of the campus to either side, will serve as a state-of-the-art laboratory facility for basic and clinical neuroscientists. A vivarium and NMR suite are located in the basement. The ground floor includes three laboratory suites, a large conference room, admin offices, a cafe, and a loading dock. The balance of the building houses 24 laboratory suites, support space, and office suites with mechanical space located in the rooftop penthouse.

― WHAT IT IS

The labs are designed to allow for in vitro and in vivo research on a variety of pathogens.

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― WHAT MAKES IT COOL

The building responds in many practical and energy efficient ways to the client's program, site context, and the climate of Southern California.

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"Perkins and Will pulled together a strong team of designers, engineers and other consultant who had a good understanding and knowledge of the technical requirements of our facility. Perkins and Will led this coordination effort well. Our project faced many unforeseen challenges along the way, and the project team, led by Perkins and Will, consistently rose to these challenges, and devised good solutions."

-Brian E. Henderson, M.D., Keck School of Medicine, University of Southern California

South Lake Union School of Medicine Phase 3.1 Seattle, Washington Client: University of Washington Size: 312,000 square feet Completion Date: 2013 Biosafety Levels: BSL-2, BSL-3, ABSL-3 The new research tower was designed to achieve the School of Medicine's vision of building a highly competitive research facility that would meet the growing needs of cutting edge research and science teaching, investigation and discovery. The open BSL-2 labs are located along the building perimeter, where they receive maximum daylight and views.

Scientists' offices were pulled out of the lab areas and relocated; providing unobstructed views from offices to lab areas. The BSL-3/ABSL-3 suite is located on the topmost inhabited floor of the building for maximum security. The suite was designed for work with select agents and the planning allows the facility to easily grow and shrink the area dedicated to select agent work.

Awards: P3 Innovation Project Award, All Phases, The National Council for Public-Private Partnerships (NCPPP), 2014

― WHAT IT IS

A 7-story research tower designed to facilitate collaboration and transparency among researchers.

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Select agent studies require more stringent security requirements, registration of employees, and often unique protective equipment requirements. Via program adjustment to the access control points within the suite, and simple relocation of PPE to the newly designated vestibule space, the select agent area of the facility can grow and shrink with no physical modification to the lab.

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― WHAT MAKES IT COOL

The facility provides a significant increase in research square footage for the school. Designed to be open for collaboration and flexibility, the labs also have expansive views to the exterior and close access to office space directly outside the bench space.

↑ A progressive lab planning model was implemented to provide flexibility in designating select agent areas in the BSL-3/ABSL-3.

→ The BSL-3/ABSL-3 suite is designed with a racetrack corridor around it, providing the opportunity for views to the exterior and views into the labs along a clear tour route.

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→ With over 400 researchers working and interacting in labs designed for immunology, rheumatology, BSL-3, a vivarium, vision science, and CERID research, this arrangement also adds an extra level of safety and oversight.

Our Team

Ed Cordes

Jeff Zynda

Jason Chan

Alex Clinton

LeaAnne Leatherwood

Jim Chen

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For more information, contact: scienceandtechnology@perkinswill.com