AAVLD 2020-VDL

Veterinary Research and Diagnostics AAVLD 2020 ―

American Association of Veterinary Laboratory Diagnosticians Annual Meeting / Conference

Veterinary Research and Diagnostics

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National Bio and Agro Defense Facility Manhattan, Kansas Client: United States Department of Homeland Security Size: 708,000 square feet Completion Date: 2021 The NBAF is an integrated foreign animal and zoonotic disease research, development, and testing facility which will enhance the nation's capabilities to ensure agricultural animal health.

The facility provides a full range of research space types and capabilities for agricultural pathogen study never before seen in the United States. As the nation's first BSL-4 facility capable of handling in vivo research with large animal models, NBAF will allow researchers to study some of the world's most destructive newly emerging diseases, such as the Nipah and Hendra viruses. Meanwhile the BSL-3Ag and BSL-3 portions of the building will study the more common foreign animal and zoonotic diseases that continue to threaten public health and agricultural economies around the world.

― WHAT IT IS

A high containment facility of unprecedented scope that will allow researchers to study foreign animal and emerging diseases in a state-of-the-art facility designed to the highest standards of biosafety and biosecurity.

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The United States' first facility capable of in vivo studies with large livestock in a BSL-4 environment. This will become the new home for research of foreign animal disease in the United States. The NBAF will replace the aging Plum Island Animal Disease Center off the coast of New York.

The NBAF's effluent Decontamination System consisting of eleven 7,500 gallon tanks is the current record holder for "Largest Effluent Decontamination System in the world."

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― WHAT MAKES IT COOL

As a key national asset, NBAF will become the international icon for biocontainment around the world.

The NBAF includes 100% N+1 redundancy on all building systems with the capability to remain off the power grid for up to 14 days without outside power and 24 hours without off-site domestic water.

“The NBAF will be a key component in our joint effort with USDA to advance research, which is critical to the security of our nation’s food supply and agricultural economy."

Under Secretary Dr. Reginald Brothers, Department of Homeland Security, Science and Technology Directorate

To achieve a more efficient work day, the NBAF includes a lunch room inside the containment area of the building. This is made possible by carefully integrating the building design with protocols required both prior to exiting higher risk BSL-3 areas and at the entry to the lunch room. The lunch room is visible from the lobby and connects visually with the informal break area outside containment with a view out through the front of the building.

Clockwise from Top Right: Lobby, BSL-3 Laboratory, Main Entrance, BSL-4 Necropsy

The only high containment facility in the world designed to be tornado-resistant up to an EF-5 tornado and winds of 230 mph.

Global Health Research Complex College Station, Texas Client: Texas A&M University Size: 107,000 square feet Completion Date: 2020 The GHRC's research programs are centered around the prevention of emerging and infectious diseases affecting both livestock and humans, bioterrorism countermeasures, food safety, and disease diagnostics and detection. It is one of the few research facilities in the world that has dedicated training capabilities for both BSL-3Ag large animal and BSL-3 laboratory research protocols and practices. It is meant to be a catalyst to fuel synergistic connections between the University's biomedical, veterinary, engineering, and health programs.

― WHAT IT IS

A modern, cuttingedge biocontainment facility to study high consequence infectious diseases.

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Global Health Research Complex

― WHAT MAKES IT COOL

One of only a very small handful of modern BSL-3Ag facilities in North America. The GHRC is designed to allow researchers to works with a wide range of species, from mice to bison.

“This facility is really a crown jewel, not just for the Division of Research for Texas A&M University and the state of Texas, but really a very important asset for the nation and for our global partners in addressing disease." -Dr. Mark Barteau, Vice President for Research, Texas A&M University

Global Health Research Complex

Research programs are centered on the prevention of emerging and infectious diseases affecting both livestock and humans, bioterrorism countermeasures, food safety, and disease diagnostics and detection.

This complex is a catalyst to fuel synergistic connections between the University’s biomedical, veterinary, engineering, and health programs.

Texas A&M Veterinary Medical Diagnostic Laboratory (TVMDL) College Station, Texas Client: The Texas A&M University System Size: 93,000 square feet Completion Date: 2017 Awards: Award for Project Excellence (APEX), General Contractor of Houston, 2019

1 of 3 projects designed for TVMDL; repeat work from a relationship dating back to 2009.

The TVMDL has received some of the planet's largest mammals; elephants and giraffes have been brought in from zoos nearby Houston and Dallas on more than one occasion.

― WHAT IT IS

The State of Texas's front line of defense for rapidly identifying the outbreak of a high-consequence agricultural pathogen.

TexasA&MVeterinaryMedicalDiagnosticLaboratory(TVMDL)

― WHAT MAKES IT COOL

As one of the highest volume veterinary labs in the nation, case loads average more than 200,000 per year.

"A remarkable facility, by far the best vet diagnostic lab in the country.

Others may try to build better, but it will be very difficult to do so."

- Chancellor John Sharp

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This building serves as a replacement for the aging TVMDL facility on the Texas A&M University Campus. The facility addresses any potential high-consequence disease outbreak which could result in economic losses of billions of dollars and trade restrictions that could halt exports of Texas agricultural products. As one of the highest volume veterinary laboratories in the nation, they average more than 200,000 cases each year. Routine testing serves as the national backbone of a state, national, and global surveillance system, and supports animal health as well as trade, exports, and the economic structure of agriculture in Texas.

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Texas A&M Veterinary Medical Diagnostic Laboratory (TVMDL) Canyon, Texas Client: The Texas A&M University System

The new Texas A&M Veterinary Medical Diagnostic Laboratory

Size: 17,680 square feet

at West Texas A&M University in Canyon, Texas replaces the

Completion Date: 2020

aging TVMDL facility located in Amarillo. This facility is one of four laboratories in the statewide TVMDL network, and is focused on serving clients in the West Texas region. Like its sister facilities, this new laboratory sits on the front line of defense against high consequence disease outbreaks in the livestock populations in Texas.

The facility includes 8,000 square feet of BSL-2 diagnostic laboratory space, including Clinical Pathology, Bacteriology, Virology, Serology, and Molecular Diagnostics; and 5,000 SF of Administrative space. Additionally the facility includes a BSL-3 Enhanced laboratory and a highbay Necropsy space designed to accommodate large livestock species.

→ An open lab concept with flexible furniture systems and utilities are shared by all diagnostic sections.

“We have created a two-way superhighway of veterinary education and research activity from Canyon to College Station, and it runs right through these new structures.” ― CHANCELLOR JOHN SHARP

Texas A&M Veterinary Medical Diagnostic

“This arrangement is the perfect model of how, through collaboration with the System’s regional universities and state agencies, we can expand our reach and our impact on the lives of Texans.” ― TEXAS A&M PRESIDENT MICHAEL YOUNG

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“The Texas Panhandle leads the nation in livestock production, so it is vital that we continue to provide this region with exceptional graduates. Our success here also informs our approach with the three other partnerships that make up our statewide, system-wide initiative.”

- DR. ELEANOR M. GREEN, TEXAS A&M DEAN OF THE COLLEGE OF VETERINARY MEDICINE

Texas Institute for Preclinical Studies College Station, Texas Client: Texas A&M University Size: 105,000 square feet Completion Date: 2009 Awards: Turnkey Facility of the Year, ALN Magazine, 2010 The facility includes a large animal (pig, sheep, and cow models) surgery suite with two operating rooms, ICU's, prep rooms, and sponsor labs. The imaging center includes a 7 Tesla large Bore MRI and a 3T MRI. The facility includes three large outdoor holding paddocks of approximately nine acres with support buildings. Indoor holding facilities include 18 large animal holding rooms each capable of accomodating 12 animals for a total capacity of over 200 animals. The office for technology commercialization and nine biomedical research labs are located on the second floor. The facility also includes a 140-seat auditorium.

― WHAT IT IS

A core Good Laboratory Practices (GLP) center for translational research and preclinical studies.

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"This is the first time in history the quality of the facility matches the quality of the people who work in it." -Dr. Brett Giroir, Texas A&M Vice Chancellor for Research

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― WHAT MAKES IT COOL

As a result of improved synergies and integrated capabilities, the Institute enhances competitiveness for sponsored research from state, federal, and commercial entities.

Its primary purpose is to conduct medical device and combination product safety studies in large animal models. The core imaging center associated with TIPS participates in clinical and preclinical research.

Clockwise from Top Right: OR, Scrub Room, OR, Conference Room

University of Maine at Orono, Animal, Plant, and Insect Control Diagnostic Lab Orono, Maine Client: University of Maine ― Size: 23,200 square feet ― Completion Date: 2018

Supporting the Maine Agricultural Community The APIC laboratory was conceptualized to meet the needs of the agricultural community in Northern Maine. In recent years, there have been increasing occurrences of invasive plant and animal pathogens that impact the region. However, dedicated facilities to rapidly diagnose and respond to these challenges have not existed or are insufficient to meet the demands for safe and secure facilities to effectively handle higher-level pathogens. The APIC lab’s goal is to provide a robust facility for the public to bring specimens for analysis as part of the University of Maine’s Cooperative Extension service. It is Maine’s first Biological Safety Level Three laboratory capable of Select Agent pathogen research.

University of Maine at Orono, Animal, Plant, and Insect Control Diagnostic Lab

Specialized Laboratory The facility provides Biosafety Level 2 and 3 capabilities for cell-culture, PCR, Histology, large and small animal necropsy and support spaces for all programs. The facility has been designed to allow the public to view diagnostic procedures without exposure to the potential biohazards from a specially designed public viewing and education room; allowing direct visual access into large animal necropsy suite.

Clockwise from Top Right: OR, Sample Analysis Laboratory, OR from viewing area, BSL-3 laboratory

Global Animal Health Phase 2 Pullman, Washington Client: Washington State University ― Size: 67,500 gross square feet ― Completion Date: 2021

The Washington Animal Disease Diagnostic Lab (WADDL) is on the front lines of our region's and nation's defense against emerging and foreign disease and food born illness, and yet their current home requires them to transport potentially dangerous samples through one building, outside, and into another in order to reach their BSL-3 lab. This called for a new addition to the Paul G. Allen Center for Global Animal Health at WSU, which will consolidate the labs into one area to enhance biosecurity and biosafety.

As the architects on the design-build team, our first order of business was to understand how the labs process samples so we could design a facility that enhances their efficiency. When completed, Global Animal Health 2 will provide a new home for WADDL with enhanced sample security and workflow, biosafety, and biosecurity. It will also provide more synergy between the Allen School and WADDL to develop advanced testing, implement innovative tools, and train the next generation of scientists and diagnosticians to advance global health security.

Global Animal Health Phase 2

"We have been extremely happy with the Perkins and Will and Bouten team. They have spent many hours with our lab personnel getting our overall facility and each lab space built to our current and future needs. Very creative, very practical, and very good listeners. Great process!

- TIM BASZLER, DVM, PHD, PROFESSOR, PAUL G. ALLEN SCHOOL FOR GLOBAL ANIMAL HEALTH

Thoughtful Design We set out to design a facility that has it's own distinct identity, but blends well with other structures on campus. We did so by creating a new and modern front door while incorporating the same brick and glass seen throughout campus.

The facility was planned to separate office and laboratory traffic, increasing operational efficiency, biosafety, and biosecurity.

Clockwise from Top Right: Hallway with view into a lab, Transparency into workspaces from the stairwell, Atrium view

Veterinary Diagnostic Laboratory Ames, Iowa Client: Iowa State University ― Size: 147,000 square feet ― Completion Date: 2023 (est.)

― WHAT IT IS

The largest full service and fully accredited veterinary diagnostic laboratory in the United States.

The Iowa State University Veterinary Diagnostic Laboratory (VDL) is a component of the Iowa State University College of Veterinary Medicine (CVM), and combined with the Food Supply Veterinary Medicine section, Veterinary Extension, and Veterinary Field Services, forms the department of Veterinary Diagnostic and Production Animal Medicine (VDPAM) at Iowa State University. As the only full service and fully accredited veterinary diagnostic laboratory in the state of Iowa, the ISU Veterinary Diagnostic Laboratory serves to protect animal and human health and advance Iowa’s $32.5 billion dollar animal agricultural industry by providing timely, high quality, comprehensive veterinary diagnostic services; teaching veterinary students, graduate students, future diagnosticians, and veterinary practitioners; and conducting applied research to advance diagnostic and production animal medicine.

― WHAT MAKES IT COOL

A cutting edge new facility that brings veterinary students and worldclass diagnosticians together to maintain a vigilant eye on the health of the nation’s livestock industry.

Identifying Challenges

Looking Forward

The current space where the VDL is operating is functionally

A new veterinary diagnostic facility was identified as the

obsolete, inefficient, and unsuitable for modern research.

next capital building priority for Iowa State University. As

The VDL is a concentration point for receiving and handling

a result of the planning verification study we confirmed

a broad spectrum of biological specimens from clinically

programmatic space requirements for the VDL, determined

ill or deceased animals whose cause of illness is unknown.

the potential scope of the project, evaluated prospective

Many pathogens and toxins that cause ill health or death of

sites for a new facility, and factored in additional project

animals can also cause disease in humans. Thus, protecting

components such as the pathological incinerator and the

the health of the employees and students that work at the

heating and cooling plant. This recommendation also

VDL is of utmost concern as is the importance for containing

outlines a clear way forward for the eventual completion

such disease causing agents from escaping the laboratory.

of a facility that will accommodate the entire Iowa State University Veterinary Diagnostic Laboratory operation.

This facility is being delivered using the unique Design-Build Bridging model. Perkins and Will, in partnership with INVISION of Des Moines, Iowa, is the Bridging Consultant for the project. The Bridging Consultant is responsible for developing and documenting the program, planning, and design concepts to roughly a 50% completion level, and serves as the Owner’s expert to oversee the design completion and construction performed by the Design-Build Contractor.

Clockwise from Top Right: Necropsy Level 1, Premier conference room, Necropsy viewing area, Atrium

“My compliments to the Bridging Team; you really set us up to win here.”

-Dr. Pat Halbur, Executive Director

Animal Disease Diagnostic Laboratory Stillwater, Oklahoma Client: Oklahoma State University Size: 10,000 square feet Completion Date: 2013

Perkins and Will’s laboratory design experts worked side by side with researchers to develop a successful project to meet and exceed the needs of OSU. The design incorporates large, isolated space to handle the needs of complex animal disease research.

The space designed for OSU provides safe work flow to minimize the risk of spreading infectious diseases while simultaneously protecting the well-being of humans.

The renovations and additions to the 30 year old Stillwater lab added approximately 10,000 square feet of laboratory space providing OSU one of the largest facilities of its type within the region.

Animal Disease Diagnostic Laboratory

The project includes a dedicated BSL-3 suite to handle OSU’s growing need to assess active and new viruses for animals, an important element to the Midwest economy. Key design considerations include safe guards to allow for tremendous increases in throughput of diagnostic testing. This will essentially allow the laboratory to be reconfigured, as quickly as overnight, to handle a large spread outbreak of disease.

OSU benefits from improved work flow which organizes space, making animal research and disposal more efficient and safe.

Texas A&M Veterinary Medical Diagnostic Laboratory (TVMDL) Sample Receiving Renovation and BSL-3 Addition Amarillo, Texas Client: The Texas A&M University System ― Size: 2,227 square feet ― Completion Date: 2011

Perkins and Will was hired to renovate and expand an existing facility to improve sample receiving processes and provide a BSL-3 diagnostic laboratory for the Texas Veterinary Medical Diagnostic Laboratory (TVMDL) in Amarillo, Texas. The renovated Sample Receiving area addresses biosafety and biosecurity shortcomings in the original design of the building while optimizing the accessioning process. The addition is the second BSL-3 suite for TVMDL, and provides the capability to quickly diagnose potential high consequence disease outbreaks in the region. The BSL-3 suite is designed to facilitate molecular diagnostic processes but is reconfigurable for a wide variety of diagnostic and research capabilities at either BSL-3 or BSL-2. The TVMDL protects the health of the agricultural industries of the Texas Panhandle, a vital component of the regional and national economy. It provides additional capacity to respond to agricultural events and supplements current testing capacities at Texas A&M’s main campus in College Station.

The BSL-3 suite contains clean and dirty change rooms, an equipment vestibule, and three small lab areas totaling 832 sf. Simple, costeffective moveable laboratory furniture and purposeful utility planning provide adaptability within the spaces.

― WHAT MAKES IT COOL

This facility is on the front line in the response to potential high-consequence outbreaks in the agriculturally rich Texas Panhandle region, and provides greater support to the livestock industries.

Our Team

Ed Cordes

Jeff Zynda

Jason Chan

Alex Clinton

Jim Chen

Peter Longoria

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For more information, contact: scienceandtechnology@perkinswill.com