Science and Technology: Pharmaceutical Research

― Pharmaceutical Research

Finding the right target

Contents

Introduction ― 4 Selected Projects ― 10

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― Pharmaceutical Research

Innovation is key Bringing life-saving drugs, vaccines, and therapies to market is no small feat. The average drug costs around US $2.6 billion dollars from discovery to commercialization, so we know that the optimal environment for development is crucial to success. From incubators and startups to worldwide powerhouses, we understand what it means to leverage flexible, functional design.

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Pharmaceutical Research

Breaking the mold Amidst the turbulence of digital disruptions and technological advances, the pharmaceutical industry continues its noble mission to help people live longer and better lives. We’ve never known more about the human body than now. The industry continues to refine care, targeting more complex disease states, and minimize patient side effects.

Whether you’re finding your next target, heading into clinical trials, or strengthening your pipeline, we’re here to help plan a space for innovation and a place for action.

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Pharmaceutical Research

Our Science and Technology Practice

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Global Reach

Research Labs

With 30 studios worldwide, we

Words we live by are conducting

The technical demands of

have an expansive network

practice-informed research

today’s science environments

of people available to you.

for a research-informed

require the highest standards of

Our expertise serves clients in

practice. From developing a tool

design and expertise. Our active

nearly every corner of the globe

to help project teams quantify

benchmarking tool allows us to

providing a creative knowledge

a zoned approach to reducing

not only understand singular

base and industry-specific

energy intensity in laboratory

building parameters, but also

experience from people who

buildings, to using a robotic

to create custom comparative

are truly excited about the

arm to measure ability for

analysis scenarios, provide

scope of work.

precision and automation in

the ability to include building

construction—we aim to break

performance analysis, and

the mold and provide real-

represent the data in easily

world insights.

understood graphic formats.

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Benchmarking

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― Pharmaceutical Research

Selected Projects

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Project Orion Durham, North Carolina

Client: Confidential Client Size: 174,000 square feet Completion Date: 2021 Awards: National Excellence in Construction Award, 2022

The team of leading scientists, technologists, and clinicians are urgently working to revolutionize cancer detection. Their mission is to detect cancer early, when it can be cured.

― WHAT IT IS

New laboratory, office, and warehouse facility space for innovative healthcare company.

LabCentral, Bioprocess Center Cambridge, Massachusetts Client: LabCentral ― Size: 100,000 square feet ― Completion Date: 2022― Sustainability: LEED Silver ®

Linking Programs Growing from a footprint of 28,000 square feet, the opening of ― WHAT IT IS

A connected work environment for a community of life science entrepreneurs inspired

by Cambridge’s existing urban grain.

LabCentral’s 238 Main Street location adds an additional 100,000 square feet of laboratory and office space right in the heart of Kendall Square.

LabCentral’s design uses nodes of interaction and collaboration between its residents that foster transdisciplinary research and discovery. An important goal of the project was to have their mission of creating a community reflected in the design. This initially proved challenging since their lab areas and offices spaces were in two separate buildings at the 238 Main Street location. The solution was to create a single bridge that spans an atrium, thereby connecting the two programs into a single one-up/one-down configuration in which a single non-aligned floor is shared by both programs.

LabCentral, Bioprocess Center

A Colorful Direction Color, wayfinding, and transparency enhance the human experience by encouraging engagement between employees in different programs. Vibrant colors – magenta, orange, lime green, cyan, and sunflower yellow - are used to identify lab locations while also adding an uplifting energy to the space. The colors are reflected into the office spaces – on walls, furnishings, and flooring – to continue the vibrancy throughout. Glass plays an important role in creating transparency: those working in the lab can feel connected to their colleagues passing by, and vice versa.

Each floor has a unique café space and was purposefully designed to feature a specialty attraction, such as a cold brew tap or a soft serve machine. The intent of this is to encourage residents to explore the different floors, prompting spontaneous interactions with their colleagues along the way.

Rubius Therapeutics, New Headquarters Cambridge, Massachusetts Client: Rubius Therapeutics Size: 48,00 square feet Completion Date: 2019

The Growth of a Start-up Rubius Therapeutics is a rapidly growing start-up focusing on cutting-edge red blood cell therapies. Their new workplace symbolizes the maturation of their company, which embodies the culture that they continue to build as a young company.

Previously, offices and labs were located in separate buildings; now, collocated in the same structure, the company is able to grow and function together a cohesive team. We prioritized transparency through an open workspace plan, with private offices aggregated at the center of the floor plate. And we did our part to build community cohesion with work and science zones are supported by a variety of gathering spaces—like a multi-purpose café, library, lounge, and game area, as well as phone rooms and heads-down workspaces.

Rubius Therapeutics, New Headquarters

― FUN FACT

95% of work spaces have access to daylight and views.

Rubius Therapeutics, New Headquarters

Sense of Place Contrasting finish palettes echo the warm, vernacular textures found throughout Cambridge and Boston as well as the cool, scientific nature of the technical work. Rubius feels a strong connection to their new location in Kendall Square, the epicenter of the Life Sciences industry, so lower-level laboratories— lacking access to daylight—are lined with fullheight murals of the surrounding city overlaid with quotes reinforcing the company culture.

Strategic lighting illuminates the graphics while providing appropriate lighting levels for lab tasks.

↑ Contrasting palettes of warm and cool echo the textures found in surrounding neighborhoods.

← Labs are located in the building’s lower level; lacking access to natural daylight, we incorporated panoramic views of the surrounding city overlaid with Rubius’ core values.

Rubius Therapeutics, New Headquarters

Below and Right: With the headquarters split over multiple levels, we encouraged movement to the lower level with the “Fun Zone” —an area for games and relaxation—and bleacher seating to accommodate large group gathering.

Tenant Improvement Seattle, Washington Client: Bluebird Bio Size: 25,000 square feet Completion Date: 2019 Sustainability: LEED Gold®, WELL Certified™

Bluebird Bio is a Cambridge-based company that has expanded their facility in Seattle with open lab spaces, team meeting spaces, and a staff lounge named “The Aviary” that opens onto a roof terrace overlooking Lake Union.

The space pays homage to their other facilities through finishes and graphics but roots themselves locally through their northwest spirit of innovation. The large open lab faces water views and is designed for flexibility with ceiling utility panels and mobile casework. Full-height glass between the lab and work stations foster connection with the work front and center, and bring daylight into the space.

Tenant Improvement

― WHAT MAKES IT COOL

Local saltwater wood, with holes bored by teredo clams, covers a wall in the large conference room to create a unique backdrop that identifies the Seattle location on video calls.

R&D Headquarters Cambridge, Massachusetts Client: BlueRock Therapeutics Size: 50,000 square feet Completion Date: 2022

Promoting Creative Collisions BlueRock, a transformative research company, wanted a new executive headquarters in Kendall Square. As part of their Centers of Excellence expansion, the project provides a home to researchers developing new medicines for diseases by investigating and creating novel cell and engineered cell therapies.

Our team worked to design research-specific laboratories coupled with a central collaboration space for operations and leadership, creating a cohesive and creative environment that will accommodate the company as it grows.

At the heart of this laboratory facility is a cGMP hub consisting of four suites for early stage production. As tenant space, this was only possible through a careful core and shell design and strategic facade ingress points that allowed for clean room materials to be inserted within the structure.

R&D Headquarters

― WHAT IT IS

A new R&D headquarters and laboratory facility with a specialized cGMP “hub”.

Confidential Pharmaceutical Client Headquarters Westborough, Massachusetts Client: Confidential Size: 250,000 square feet Completion Date: 2020

Building Community.

When this client established a new Institute of Regenerative Medicine, they needed to find a home for this new global hub for regenerative medicine and cell therapy research – a home that would unite two previously distinct companies under one roof and support the Institute’s dynamic growth.

We transformed a suburban office building into a highly flexible, stateof-the-art life sciences facility that provides a collaborative environment in support of the Institute’s mission and culture. To create a sense of community within the building’s large floor plates, we introduced a Main Street that weaves through the center of building, connecting the different neighborhoods organized along the path. People are drawn to the activity of informal meeting areas, coffee stations, collaboration zones, and the light-filled atrium at the heart of the building. Laboratory environments and workspaces are visible throughout, displaying the innovative research taking place and uniting people around the therapies being developed.

Confidential Pharmaceutical Client Headquarters

There’s no place like home.

By bringing together two different companies under roof, we were presented with the unique opportunity to define the culture of this new Institute and build upon its strengths. We helped articulate the core values and mission of the Institute, which guided every design decision as early as site selection. After evaluating multiple sites against the project’s guiding principles, we determined that the suburban Westborough location would allow for retention of the existing core workforce while supporting recruitment strategies that were critical to the company’s growth.

― WHAT IT IS

An integrated workplace that unites the cultures of different companies in a flexible environment designed to grow with the company.

Confidential Pharmaceutical Client Headquarters

Creating Connections.

To bring a more intimate scale to the building’s large floor plates and foster collaboration among different groups, we created neighborhoods for each department and organized them along a central “Main Street.” The informal meeting areas and coffee stations found along the path offer opportunities for interaction, but the real activity is in the central Hub, a two-story, light-filled atrium where people are drawn to the conference rooms and main cafeteria. This is where you enter the building, greeted by a warm palette of natural materials accented by a vibrant red. From here, clear wayfinding signals guide you along the Main Street to bring you to your destination, encouraging movement, collaboration, and innovation.

Managing Uncertainty.

A significant challenge was planning spaces for 250 people when the Institute was only 45 at the start of the project.

By utilizing our deep benchmarking data, we were able to anticipate the typical space types and proportions that the Institute would need as it grew. This allowed us to design flexible laboratories that can adapt to different uses, without needing to know precisely what research will be taking place.

This level of flexibility will also allow for response to future changes in the market by having a facility that can adapt to changes in science or research programs.

Confidential Pharmaceutical Client Headquarters

A Powerful Transformation.

The 1970’s office building that the client would call home was not designed to support the infrastructure required by the intensive utility needs of laboratory environments. In order to transform this building into a flexible, state-of-the-art facility, we utilized a rigorous programming process to gain an understanding of the laboratory and support spaces that would be developed, which in turn determined the required ― WHAT MAKES IT COOL

utility loads and associated infrastructure. Through a zoned approach to the design, we were able to bring the additional

Transformation of a suburban office building into a modern, highly flexible research environment.

infrastructure to the flexible lab environments without overdesigning the office space, limiting the potentially costly reinforcements to the building structure while still providing the ability for future flexibility and expansion.

Just Evotec - Project Access Redmond, WA Client: Just Evotec Biologics

Just Evotec Biologics is a pharmaceutical company with the

Size: 128,000 square feet

mission to ‘dramatically expand global access to biotherapeutics’.

Completion Date: April 2020

The planning and design of their manufacturing plant is driven by their mission to deliver lower cost pharmaceuticals to developing countries. The plant utilized pre-fabricated pods inside a clean room ballroom concept, which provides flexibility for rapid expansion, multiple lines of drug production within this one facility, and a prototype concept that can be replicated anywhere in the world.

This new manufacturing facility in Redmond is constructed within an existing precast tilt-up shell and core building. The program consists of manufacturing space, manufacturing support spaces, plan and clean utilities spaces, QA/QC labs, process development labs, GMP warehouse space, cold rooms, shipping and receiving areas, and office areas with associated amenity spaces such as conference rooms, lounges and break rooms.

The manufacturing facility expands their footprint in the Seattle area to align with a company ethos centered on fairness

The Entry Lobby shares common space, conferencing and break areas to serve as a centralized active hub throughout the day.

and equality.

Just Evotec - Project Access

Clockwise from Top Left: High bay office and lobby spaces are the office neighborhood collaboration zones.

Multiple products can be run in small batches due to the manufacturing area configuration of prefabricated clean room pods in an open ballroom space.

Workplace neighborhoods are adjacent to lab environments with strong visual connections to build community and provide great access to daylight and views.

Institute for Collaborative Science Cambridge, Massachusetts

Client: Confidential Size: 62,000 square feet Completion Date: 2022 Sustainability: Tracking LEED Gold

Designed to Advance Research To harness the creative power of research collaboration, our client needed a research facility that harnessed the power of multi-facet discovery. The facility will be a home to Oncologists, Neurobiologists, Infectious Disease-focused virologists, and computational biologists, as well as two-dozen other research disciplines, each tasked with advancing some of our clients’ most challenging research efforts.

To support a variety of vaccine developments, cell and gene therapies and basic research efforts, our team developed a small-footprint standalone vivarium within a larger life-sciences research center. Organized to maximize research capabilities, each space was carefully designed to optimize research functions, maximize cage-count and provide

The double-height entrance area surrounds a sculptural staircase, serving as an important connector to the laboratories upstairs.

flexibility for future changes in research needs, especially those related to animal species.

Institute for Collaborative Science

Using minimal footprint for support and logistics, this fit-out relies on a single point for all incoming and outgoing deliveries, while maintaining operational clean / soiled flow separation.

The key challenges were to coordinate N+1 redundant stand-alone systems in a high-rise research building context with limited routing and access to mechanical plant space. The resulting design is a cGMP-capable facility that stands alone but also allows ease of access to multiple research groups in surrounding nonvivarium spaces. ― WHAT MAKES IT COOL

The transformation of a standalone vivarium within a larger life-sciences research center.

Top to Bottom: Cafe; Enclosed meeting space; Open conference area near entrance; Labs with visual connection.

Even within the stringently regulated environment, the human aspects of working within a vivarium environment were not ignored. All procedure and diagnostic spaces have access to natural light and views, providing an amenity for the technicians who work long hours in this facility.

Manufacturing & Office Buildings Bothell, Washington Client: Confidential Client Size: 110,000 square feet Completion Date: 2021

This confidential client is renovating two buildings in Bothell, Washington into a cleanroom manufacturing facility to provide offices, laboratories, cGMP manufacturing suites, and a warehouse to support drug manufacturing of personalized treatment of solid tumor cancers.

The design for this client is conceptualized around the idea that geological time frames gave traction to Darwin's theories of evolution. Likewise, the manufacturing facility is centered around science that has been built over time and seeks to provide the next layer of scientific knowledge and discovery, writing its name in history. We imagine the space referencing this idea through a rhythmic linearity as time is often represented, moment by moment and step by step.

This linearity will guide circulation, textures, and materiality throughout the office and amenity spaces.

As a juxtaposition to the lineal path, the space will be interrupted by touch down and gathering spaces that interrupt the rhythm, creating moments out of the typical circulation zones that guide staff and guests through the Clockwise from Top Right: Entry Reception Desk

space. Materiality will be authentic and selected through its reference to the time it took to create in the natural

Office and Lab support

environment. Wood grain and steel that will naturally

Reception Area

patina as the space is used will be featured accents.

Manufacturing & Office Building

Concept

The design for Lyell is conceptualized around the idea of time as scientist Charles Lyell’s research gave way to the acceptance that all of Earth’s processes are produced by long periods of time. Likewise, the Lyell manufacturing facility is centered around science that has been built over time and seeks to provide the next layer of scientific knowledge and discovery, writing its name in history.

We imagine the space referencing this idea through a rhythmic linearity as time is often represented, moment by moment and step by step. This linearity will guide the stair railing design, views into lab spaces, and textures throughout the space. As a juxtaposition to this linearity the space will be grounded through large boxes that interrupt the rhythm, creating moments and guiding employees and guests through the space. Materiality will be authentic and selected through its reference to the time it took to create in the natural environment. Wood grains and hot rolled steel that will naturally patina as the space is used will be featured.

Lyell Style Guide Logo

Logo Files Full Color Logo Mark

| OCTOBER 18 2019 |

Logo File Format

The full-color logo is the preferred visual expression of the Lyell brand and should be used as the primary logo in all applications, whenever possible.

1"

x

The logo is provided in various file formats. Please see below for their intended use.

- EPS/AI/PDF = Mainly used in print. Vendors or designers prefer these formats.

- PNG = Can be used in print or web. No background so graphic/color underneath will show through.

- JPG = Can be used in print or web. Solid white background so graphic/color underneath will not show through.

Logo Color Types

Minimum Space

Minimum Size

Logo Variations

The Lyell logo must have an empty space around it at a minimum size of half the x-height of the capitol letter “L”, shown above.

The logo should not be reproduced smaller than 1 inch wide or 72px wide.

The logo can also be produced all white, black and greyscale.

Primary Colors

- Pantone = Professional printing.

- CMYK = Office printing.

- RGB = Website or screen use.

Secondary Colors PMS 320 C96 M0 Y31 K2 R0 G151 B164 HEX #0097A4

PMS 110 C2 M22 Y100 K8 R221 G160 B32 HEX #DDA020

PMS 338 C65 M0 Y48 K0 R84 G191 B162 HEX #54BFA2

PMS Black 6 C68 M61 Y50 K32 R77 G80 B89 HEX #4D5059

R210 G130 B100 HEX #D28264 R86 G99 B138 HEX #56638A R181 G179 B142 HEX #B5B38E R54 G116 B159 HEX #36749F R11 G63 B77 HEX #0B3F4D

Typography

Montserrat

abcdefghijklmnopqrstuvwxyz ABCDEFGHIJKLMNOPQRSTUVWXYZ 0123456789

The primary typeface used for the logo and promotional applications is Montserrat. https://fonts.google.com/specimen/Montserrat If Montserrat is not available on your computer (or if it is not accessible to others who might be sharing a file in PowerPoint or Word), Helvetica or Arial fonts may be used as a substitute.

Clockwise from Top Right: Visual connections between the lab and clean room environments enhance collaboration and safety.

Workstation and Touchdown Staff connect and interact in the centralized break room space.

Montserrat Weight Varieties

Arial Weight Varieties

Montserrat Light

Arial Regular Arial Bold Arial Black

Montserrat Regular Montserrat Medium Montserrat Semibold Montserrat Bold Montserrat ExtraBold Montserrat Black

Helvetica Weight Varieties

Helvetica Light Helvetica Regular Helvetica Bold

R&D Headquarters Cambridge, Massachusetts Client: Confidential ― Size: 100,000 square feet (45,000 square feet lab, 55,000 square feet office) ― Completion Date: 2021

― WHAT IT IS

A New Home for Innovation

Four floors of cuttingedge research space that feels like a small and interconnected “start-up” company.

After finding that their growth was outpacing their current laboratory space, this biotechnology company sought a new headquarters designed to reflect their tight knit community of fearless innovators. The client occupies floors 7-10 within a new building bringing biotechnology companies into a single ecosystem, fostering collaboration and innovation.

Though this is a high-tech company at the forefront in cell and base gene editing, they remain humble in their appearance with a steadfast focus on the patient in all aspects of their work. They wanted these qualities reflected in their facility.

Each of the four floors has an approximate 50/50 lab/office split with a specialty automation lab on level 10.

R&D Headquarters

Balancing Public and Private Spaces Taking cues from the urban grid of the surrounding area, the design proposed unique nodes of interaction, collision and visual interest through a series of internal intersections.

A key aspect of the design was to make four floors of research space feel like a small and interconnected “start-up” company.

Programmatically divided into public facing events along a “tour route” and balancing a more private client community, circulation consists of a non-continuous, open stair that connects the company across all four floors.

Above: The main cafe serves as a space for employees to gather and collaborate in smaller groups and also hosts allcompany meetings and external speaking engagements.

Below: Lab spaces provide a highly adaptable and enable efficient workflow.

Takeda Research and Development Headquarters Cambridge, Massachusetts Client: Takeda Pharmaceuticals Size: 180,000 square feet (16,723 square meters) Completion Date: 2015 Sustainability: LEED Gold® Awards: Award of Excellence, IFMA, 2017

― WHAT IT IS

A state-of-theart research and development environment for a global pharmaceutical company.

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Takeda Research and Development Headquarters

― WHAT MAKES IT COOL

Designed to engineer serendipity where people run into one another by chance, which increases the chances of crossdisciplinary engagement.

According to Japanese legend, a person who folds 1,000 origami cranes will be granted one wish – a tradition embraced by Takeda as an expression of its aspiration to cure cancer. Sharing Takeda’s hope, our team felt a responsibility to create an R&D headquarters that would support the collaboration required to solve some of the world’s biggest health problems.

For more information, contact: scienceandtechnology@perkinswill.com