What are the benefits can we get from Pyrroloquinoline quinone (pqq) supplements?

There are numerous pyrroloquinoline quinone benefits including:

i. PQQ promotes the mitochondrial function

Mitochondria are organelles that produce energy in the cells in form of ATPthrough cellular respiration. They are often referred to powerhouses for thecell or energy factories.

Energy production is the key to a healthy being.

Mitochondrial dysfunction has been linked to several disorders such asreduced growth, muscle weakness, neurodegenerative disorders like cardiacdisease, depression and diabetes among other health conditions.

Pyrroloquinoline quinone enhances the mitochondrial function by stimulating production of new mitochondria cells (mitochondrial biogenesis). This occurs by activation of CAMP responsive element binding protein 1(CREB) and Peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha, pathways that boost mitochondrial biogenesis.

Pyrroloquinoline quinone also increases the transcription factors that function as antioxidants within the mitochondria hence protect us from oxidative stress.

Pqq further triggers enzymes in the mitochondria that increase energyproduction.

In a rat model, PQQ deficiency in the diet was reported to impair themitochondrial function.

ii. PQQ Relieves inflammation

Chronic inflammation is at the root of many disorders such as cardiac disease and diabetes. Pyrroloquinoline quinone has antioxidant properties that help it get rid of free radicals thus prevent inflammation and cell damage.

Some research shows that PQQ supplementation results in a remarkabledecline in numerous markers of inflammation such as nitric oxide in just threedays.

In a study of mice suffering from rheumatoid arthritis, PQQ administered wasreported to offer protection against inflammatory degeneration after 45 days.

iii. PQQ improves brain health and function

Pyrroloquinoline quinone has the ability to grow the brain again (neurogenesis)through production of numerous nerve growth factors.

One study concluded that pqq supplement stimulate nerve growth factor (NGF)synthesis and neuron cells.

Pyrroloquinoline quinone has been associated with improved memory andlearning due to its ability to regenerate the cells of the brain.

In a study consisting of 41 healthy but elderly individuals, PQQ administered at20 mg/day for 12 weeks was found to hinder the reduction of the brainfunction, more so in attentiveness and engaged memory.

Pyrroloquinoline quinone may also help in preventing brain injury.

In 2012, a study of rats given pqq for 3 days before a traumatic brain injuryfound that the supplement was able to protect the brain cells against thisinjury.

iv. PQQ improves sleep

Pyrroloquinoline quinone (PQQ) aids in enhancing your sleep quality byreducing the time taken to fall asleep, increases the duration of sleep andimproves the overall sleep quality.

Pyrroloquinoline quinone can also potentially lower the amount of stresshormone (cortisol) within individuals and hence improve their sleep.

In a study of 17 adults, PQQ given at 20 mg/day for 8 weeks was found toimprove the sleep quality in terms of increased sleep duration and lower sleeplatency.

v. PQQ improves heart health

The ability of pyrroloquinoline quinone to control the levels of cholesterolmakes it reduce the risk of heart disease such as stroke.

In a study of 29 adults, supplementation of pqq significantly reduced the badLDL cholesterol levels.

Pyrroloquinoline quinone also reduces triglycerides levels which lead toenhanced mitochondrial function. In a study with rats, ppq given was found tolower their triglyceride levels.

Pqq supplement may help prevent or reverse atherosclerosis (stroke). Some studies have shown that ppq can lower C-reactive protein and trimethylamine-N-oxide which are key markers of this disorder.

vi. A potential longevity agent

Pyrroloquinoline quinone is regarded a non-vitamin growth factor and hencecould help in promoting your growth and also development.

Pyrroloquinoline quinone function in fighting inflammation, preventingoxidative stress and supporting mitochondrial function proves its ability inextending one’s life.

PQQ has also been proven to activate cell signaling pathways which in turnreverse cellular aging.

The synergetic effects derived from these mechanisms enable PQQ to protectyou from cellular aging and also enhance longevity.

In an animal model, supplementation with pqq was found to reduce oxidativestress as well as extend the life span of roundworms.

vii. Protection from oxidative stress

PQQ binds to proteins hence inhibits oxidation in the cells.It is also able to get rid of free radicals in the body.

In an animal study, pqq supplementation was found to prevent oxidative-related neuron cell death.

Another study conducted in vitro reported that PQQ protected isolated livermitochondria cells from damage after oxidative stress and eliminatedsuperoxide radicals.

A further study with streptozotocin-induced (STZ) diabetic mice, PQQ given at 20 mg/kg bodyweight for 15 days was found to reduce the serum levels of glucose and lipid peroxidation products, and also elevated the activities of antioxidants in the diabetic mouse brain.

Other pyrroloquinoline quinone uses and benefits include:

•Preventing obesity

•Improves immune system

•Improves fertility

•Promotes cognitive functioning and memory

•Helps fight fatigue

In the current situation in the world, negative news due to the COVID 19 iscoming in every time. Pyrroloquinoline quinone coronavirus fight can be utilized. This exciting supplement will enhance your immunity as well offer sleep aid to relieve you stress.

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