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Can NMN Really Achieve Anti-aging Effects?
History of NMN Nicotinamide mononucleotide (molecular formula: C11H15N2O8P, CAS number: 1094-61-7, also known as NMN, beta-Nicotinamide mononucleotide or β-NMN) is a vitamin B3 metabolite [1], naturally found in the human body, and in common foods such as broccoli and cabbage in tiny amounts[2]. NMN started to gain interest as a potential nutritional supplement in 2013, after a breakthrough study conducted by Harvard scientists on mice [3,4]. NMN was first produced as a supplement for humans in 2015 [5], but was extremely expensive to manufacture, until methods were developed to reduce production costs and increase purity in 2018[6], at which point laboratories geared up for mass production started to come online.
What is NMN powder? Nicotinamide mononucleotide (molecular formula: C11H15N2O8P, CAS number: 1094-61-7, also known as NMN, beta-Nicotinamide mononucleotide or β-NMN) is a vitamin B3 metabolite [1], naturally found in the human body, and in common foods such as broccoli and cabbage in tiny amounts[2]. Nicotinamide Mononucleotide (NMN) is a naturally occurring compound that is in small amounts in the human body as well as some foods. NMN is orally bioavailable, and when taken orally can support NAD+ levels within
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liver and muscle tissue. Recent research has suggested that NMN may support cardiovascular health, energy production, cognitive health, and well as retinal and bone health. One especially interesting finding of NMN research is that it may promote DNA repair and support the activation of the SIRTUIN genes which are thought to play a role in healthy aging.
How does work? NMN is a precursor to the NAD+ molecule; the human body requires NMN in order to make its own NAD+. NAD+ is the oxidised form of NAD (Nicotinamide adenine dinucleotide), a molecule first discovered in 1906, and found in all living cells [7]. Supplementing with NAD+ itself is not an option to boost NAD+ levels, because it is too big to readily cross cell membranes to enter cells, and therefore would be unable to positively affect metabolism [8].
NMN benefits. One way that we might sustain healthy levels of NAD+ is by supplementing our bodies with its precursor, nicotinamide mononucleotide (NMN). Current research shows that this transformation between NR and NMN must take place for entry to a few cell types. This leads researchers to believe that NMN is, in fact, one of the quickest means of stimulating NAD production. However, Nicotinamide mononucleotide powder are also proving to have their own anti-aging benefits beyond those of NAD production alone. In addition to the NAD metabolic pathway, NMN powder can be added directly to cells without converting to NAD. This phenomenon is made possible by newly discovered transport proteins that increase in number after NAD levels drop off. In this form, NMN contributes to cell energy and allows each of the previously mentioned anti-aging properties promoted by cells with adequate ability to grow and regenerate. Choosing to supplement with NMN powder along with NAD provides a much more direct path to promoting cell metabolism and is thus a much quicker means of doing the same. In addition, Nicotinamide mononucleotide powder has been found to improve insulin activity and production, resulting in additional metabolic benefits as well as glucose tolerance. In particular, NMN supplements can help work to alleviate metabolic conditions like diabetes, fatty liver disease, and obesity. [11]
Other Potential Benefits of NMN
Promotes Vascular Health and Blood Flow.[11]
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Improves Muscle Endurance and Strength Protects Against Heart Disease Lowers Risk of Obesity.[10] Enhances Maintenance of DNA Repair Increases Mitochondrial Function.[9]
How to get stable, pure, safe NMN? In order to determine how a stable, authentic, pure and safe product can be achieved, a series of tests and analysis was conducted. COA, HPLC and HNMR reports can be provided.
(1)Improved stability By analyzing the Nicotinamide mononucleotide structure and using charge transfer and in-situ FTIR monitoring method, it was discovered that NMN has one inner salt structure and isoelectric point of inner salt is the key factor of NMN instability. Water, as one polar molecule, will induce electrical transfer within NMN that can destroy the quite stable inner salt skeleton of NMN. If so, NMN will show a metastable transition structure which degrades easily, namely water content in the product and free water molecules in the air will directly destroy the isoelectric point of inner salt and bring down the purity of NMN. This is a big breakthrough in NMN powder stability research, which will be one start to get improved. To improve the stability of NMN powder internally, researchers creatively developed a new NMN powder with orderly and compact microscopic arrangement.
(2)Stronger stability, longer shelf life. Phcoker NMN powder is more orderly and compact, effectively blocking the contact with free water in the air, greatly increasing the stability of NMN and extending the shelf life of the product. Contrary to the novel NMN microscopic arrangement, the first generation sawtooth structure shows more disorder and incompact, thus every molecule will get more exposure to air and absorb more water.
(3)Higher density, more stable dosage and flexible formulation. NMN powder with an orderly and compact microscopic arrangement has higher bulk density and fluidity, which avoids unstable dosage due to raising dust in the process of preparation. What’s more, it will affect uniform dosage of capsules. Meanwhile, since it has better fluidity, Our NMN powder can help reduce the production period and the manufacturing cost during the production.
(4)Guaranteed high quality and pure Third party lab testing reports should be necessary to verify the identity and purity of NNM. Each batch of raw materials must pass strict self-inspection and third-party testing. HNMR and HPLC testing reports can further confirm the authenticity, high quality and purity of NMN.
(5)Phcoker is Nicotinamide mononucleotide (NMN) powder manufacturer With self-own factory, our NMN powder monthly output is reach over 2 tons.
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Cosmetic raw material: NMN is a substance in the body of cells, and NMN is a monomer molecule，it’s anti-aging effect is obvious, so it can be used in cosmetic raw materials.
Health care products: NMN powder can be prepared by yeast fermentation, chemical synthesis or in vitro enzymatic catalysis. NMN powder widely used in the health care industry.
Reference: [1] Nicotinamide mononucleotide. From Wikipedia, the free encyclopedia.2019. [2] Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Cell Metab. 2016 Dec 13. [3] Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037. [4] A New—and Reversible—Cause of Aging. David Cameron. Harvard Medical School, News & Research, December 19, 2013 [5] A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. Science. 2017 Mar 24;355(6331):1312-1317. doi: 10.1126/science.aad8242. [6] Size Exclusion Chromatography Method for Purification of Nicotinamide Mononucleotide (NMN) from Bacterial Cells. George Cătălin Marinescu, Roua-Gabriela Popescu & Anca Dinischiotu. Scientific Reportsvolume 8, Article number: 4433 (2018). [7] Nicotinamide adenine dinucleotide. From Wikipedia, the free encyclopedia. 2019. [8] Identification of the mitochondrial NAD+ transporter in Saccharomyces cerevisiae.,Todisco S, Agrimi G, Castegna A, Palmieri F. J Biol Chem. 2006 Jan 20;281(3):1524-31. Epub 2005 Nov 16. [9] Katalin Sas, Elza Szabó, László Vécsei. Mitochondria, Oxidative Stress and the Kynurenine System, with a Focus on Ageing and Neuroprotection. Molecules, 2018; DOI: 10.3390/molecules23010191. [10] Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise.Uddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ.
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[11] Jun Yoshino, Kathryn F. Mills, Myeong Jin Yoon, Shin-ichiro Imai. Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice. Cell Metab, 2011; DOI: 10.1016/j.cmet.2011.08.014. [12] Latest Anti-Aging Drugs: Nicotinamide Mononucleotide (NMN)
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