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Nicotinamide Riboside Chloride(NRC) Review: 8 Facts You Should Know
Advances in technology and society have allowed people to pay more and more attention to personal health issues while satisfying their own food and clothing problems. In addition to the physical health we often say, external health is also very important, such as aging. Every year, millions of people out spends huge amounts on anti-aging products. Nicotinamide riboside chloride is one of many anti-aging products.Although most anti-aging products try to reverse the signs of aging on the skin, nicotinamide riboside chloride is designed to reverse the signs of aging in the body. In your body, nicotinamide ribose is converted into NAD +, which is an auxiliary molecule that exists in every cell of your body and supports many aspects of healthy aging. This article covers all the information you need to know about nicotinamide ribose chloride, including how it works, its benefits, side effects and safety.
Nicotinamide riboside chloride Many people may have heard of the term niacinamide, which is a commonly used anti-aging ingredient in cosmetic products. As a derivative of nicotinamide, NR is more effective than nicotinamide in anti-aging and other aspects. NRC is the reactant of NR and Chloride. Obviously, it perfectly inherits the advantages of NR.
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Nicotinamide ribose chloride is actually another form of vitamin B3, commonly referred to as niacin. Nicotinamide ribose chloride may also be called niacin or NRC for short. According to scientific peer-reviewed literature, nicotinamide ribose was discovered in 2004 as a vitamin precursor of NAD+, and in 2007 as a Sirtuin (deacetylase) activating compound. In many organisms, Sirtuin is also involved in regulating the health and lifespan of DNA. NAD+ is one of the most important enzymes in human physiology. As the driving substance of NAD+, NRC will be converted into nicotinamide adenine dinucleotide or NAD+ once ingested in the body to provide energy for life activities. NAD+ is related to mitochondria. The weakening of mitochondrial function means the aging of the human body, and the substance that determines the strength of the mitochondria is the indispensable NAD+ in the human body. This enzyme factor will gradually decrease with age. If we do not supplement it in time, our body may have various health problems and aging. In essence, older people will have lower levels of this important enzyme than younger people. This is where supplementation becomes very important. Using nicotinamide chlorinated ribose supplements to increase NAD+ levels, especially in the elderly, may provide many incredible benefits.
Is NRC Vitamin B3? NR is a vitamin, an organic compound, our body needs a complete biological function, but we must obtain it through diet. There are eight types of vitamin B, and NR is a small amount of vitamin B3 found in dairy products and other foods. NR is one of 2
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some variants of B3; others include niacinamide and niacin (also called niacin).
What foods contain nicotinamide riboside? NR is a naturally occurring substance. In addition to being in milk, NR can also be found in our usual diet. By supplementing these foods rich in vitamin B3, to a certain extent, the intake required by our body can be met. Here are several foods may contain NR: ●Dairy Milk– Cow milk comes loaded with a lot of Nicotinamide Riboside. ●Fish– Tuna, sardines, and salmon etc fishes all have very good levels of Nicotinamide
Riboside, if you like fish, this is a good way to get NR. ●Chicken– Eating chicken may also boost NR levels in your body as well. A serving of
chicken, roasted, fried, or stewed, contains up to 9.1 milligrams of Nicotinamide Riboside. ●Green Vegetables– Green veggies are also advisable. They are loaded with loads of
vitamins, including the all-important B3 that will be crucial in the synthesis of NAD+ in your body. ●Beer– Surprisingly, beer may also help you supplement Nicotinamide Riboside. This
is because beer has yeast as one of its main ingredients and the yeast is known to be very high in NR. ●Whole Grains- these foods are rich in vitamin B3 and RN (precursors of NAD).
However, when vegetables, foods or grains are cooked or processed, they may destroy the same and vitamins contained. Therefore, it is recommended that you 3
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should also eat raw vegetables and eat whole grains instead of processed foods. Yeast- an ingredient used to make bread and other baked products. Yeast contains the riboside nicotinamide (RN), which is the precursor of NAD. If you can’t increase your NR level through other means, you can try to add yeast to your bread making, so that you can enjoy your favorite food while increasing your NAD level. What a wonderful thing this is.
What benefits can you get from Nicotinamide Riboside Chloride ? As the reactant of nicotinamide ribose and chlorine, nicotinamide ribose chloride undoubtedly inherits the advantages of nicotinamide ribose. It not only participating in metabolism in the body, but also can be used to prevent pellagra or other niacin defection disease and to lower cholesterol and triglycerides in the blood. It is also used to lower the risk of heart attack in people with high cholesterol who have already had a heart attack. Sometimes it is used to treat coronary artery disease(atherosclerosis), protect protect the brain and the liver (cardiovascular, diabetes, Alzheimer’s disease). Besides, Nicotinamide riboside chloride also have other benefits in human: ●Proper digestion and absorption of proteins and fats; ●Help convert the essential amino acid tryptophan into niacin; ●Reduce vomiting, and reduce results of taking antidepressants due to dry mouth
and difficulty urinating; ●Promote nucleic acid synthesis and prevent aging of tissues and organs, thereby
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achieving the purpose of delaying aging; ●Slow nocturnal muscle spasm, spastic paralysis and hand and foot neuritis; ●Treatment of congenital hypometabolism and enhancement of metabolism; ●Prevention and treatment of vitamin B6 deficiency; ●Treatment of carpal tunnel syndrome; ●Helps lose weight and strengthens muscle function. ●Improve the body’s resistance to cancer cells ●Prevent hearing loss ●Is a natural diuretic.
Taking large doses can relieve drug addiction and have a good detoxification effect. Improve the function of epidermal cells, as well as the functions of other cells in the human body, to keep the skin radiant.
Is there any relationship between NMN, NRC and NAD+? Nicotinamide, also known as niacinamide, is a form of vitamin B₃ found in food and used as a dietary supplement and medication. NMN, NR and NAD+ are all its derivatives. Although they share the characteristics of nicotinamide, they are different at the same time. NAD+ is an important enzyme factor in the physiological process of the human body. It is essential for cell metabolism. It can convert nutrients into cell energy, and it can also activate sirtuin (a protein that regulates cell health). The level of NAD + will decrease with age, and it is difficult for the human body to produce NAD + coenzyme. 5
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Once this factor is reduced or absent in the human body, we will begin to get sick and gradually age. The emergence of NMN and NR has effectively solved this problem. As the precursors of NAD+, NMN and NR will automatically convert into NAD+ after entering the human body, thereby increasing the level of NAD+ in the body.
What should be paid attention to when using Nicotinamide Riboside Chloride ? (1)Doage Nicotinamide Riboside Chloride is commonly called niagen, which is sold in the market in different forms such as powder, capsule and tablet etc, and it is ingested using the mouth. Although a majority of niagen products contain just the Nicotinamide Riboside Chloride, some may also feature additional ingredients including polyphenol or Pterostilbene. Most manufacturers often recommend a Nicotinamide Riboside chloride dosage of between 250 mgs and 300 mgs per day. This is roughly the same as two capsules of the product each day. (2)Dosage for different populations Studies have shown that people of different ages and people who have used it for different periods of time are effective for increasing NAD+. Therefore, when using NRC, the dose only need to be kept within the safe dose range, and there is no need to increase or decrease the dose due to the length of use and age.
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(3)Overdose The study found that in experiments with daily doses of 300mg and 2000mg, the level of NAD+ has been significantly increased. The level of NAD+ in volunteers who took high doses was not much different from those who took low doses. However, users of high doses occasionally have adverse symptoms such as nausea, vomiting and diarrhea. Therefore, in order to avoid side effects, when taking NAC, try to keep it within a safe dosage range. (4)Interaction Clinical trials have found that NRC and other supplements can be taken safely and do not negatively affect drugs.
What are the side effects ofNicotinamide Riboside Chloride? NR is a natural product, it has argely well tolerated, almost no side effects. High oral doses may cause ♦Uncomfortable stomach ♦nausea ♦Vomiting ♦Diarrhea ♦Increased skin reactions such as rashes and bruises In addition to the side effects of nicotinamide ribose chloride mentioned above, you may also lose weight. However, this result is a blessing in disguise, especially if you are overweight, obese or trying to control your weight. 7
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Is safe to take Nicotinamide Riboside Chloride ? After understanding the benefits of NRC, you may want to buy some. But you may have questions about whether it is safe or not. Studies show that NR is a natural product and a vitamin that has been hidden in milk, it is very safe for the human body and has almost no side effects. Clinical trials have found that NRC and other supplements can be taken safely and do not negatively affect drugs. In 2016, the FDA approved nicotinamide ribose as a generally recognized safe food ingredient, including energy water (a beverage that adds some additional ingredients to drinking water), protein shakes, nutrition bars, etc. The no-observed-adverse-effect level (NOAEL) NOAEL and the lowest observed adverse effect level (LOAEL) of rodents are 300 and 1000 mg/kg/day, respectively. Therefore, it is very safe for you to take NRC supplement. Choose the brand you like, and maybe you will get unexpected surprises.
Reference [1]Conze D, Brenner C, Kruger CL. Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. Sci Rep. 2019 Jul 5;9(1):9772. doi: 10.1038/s41598-019-46120-z. PMID: 31278280 PMCID: PMC6611812. [2] Khan, Nahid A, Mari Auranen, Ilse Paetau, Eija Pirinen, Liliya Euro, Saara Forsström, 8
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Lotta Pasila, et al. Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B 3 EMBO Molecular Medicine 6, no. 6 (April 2014): 721–31. https://doi.org/10.1002/emmm.201403943. [3]Dominique Turck, Jacqueline Castenmiller etc. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J, 2019 Aug 7;17(8):e05775. doi: 10.2903/j.efsa.2019.5775. eCollection 2019 Aug. PMID: 32626405.
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