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Nicotinamide Riboside Chloride(NRC) Supplement: Do You Know What Potential Benefits It Has?
Overviews We're all probably familiar with niacin, as a member of the vitamin B family, it is often used to make bread or other foods. You can easily find it on the label of bread, cereals or other foods. But nicotinamide riboside chloride? That sounds more like something in tobacco products, right? Don't be frightened – niacin is also known as nicotinic acid. It is beneficial to the human body and is often used in some supplements or skin care products. Actually nicotinamide riboside (or NR) is just a different form of vitamin B3 than niacin. You could find it naturally in products like milk, fish and even beer. It is the precursor of NAD+, which can promote the increase of NAD+ level, thereby ensuring the body The normal operation of various organs. As a reactant of NR and chlorine, Nicotinamide riboside chloride has the same efficacy and effect as NR. This article mainly discusses the importance, benefits and side effects of Nicotinamide riboside chloride.
Why is Nicotinamide riboside chloride/NRC so important? NAD+ is essential for cell metabolism, it can convert nutrients into cell energy, and it can also activate sirtuin (a protein that regulates cell health). Through diet, the NAD + 1
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intake in all of us increases the content of NAD + precursors. NAD+ is a molecule that supports cell function in many important ways and is essential for cell metabolism. It can keep our DNA healthy, convert food into usable energy and regulate our sleep/wake cycle. Once the level of NAD+ in our body drops, it means that our body functions begin to deteriorate, and diseases (heart disease, type 2 diabetes, Alzheimer's disease, etc.) and aging will follow. You may want to ask: Why should I care about this enzyme molecule? It is not the product we will discuss in this article. If you think so, you are quite wrong. In fact, NAD+ and NR are closely related. From the working mechanism of NR, we can know that it is the precursor of NAD+. After it enters the body, it will be quickly converted into NAD+ needed by the human body to provide energy for various organ cells of the body and maintain health. Through diet, the NAD + intake in all of us increases the content of NAD + precursors. NR is a form of vitamin B3. There are dozens of food sources that can provide vitamin B3. However, compared with other forms of B3 in the diet, nicotinamide ribose chloride is absorbed relatively quickly in the body. This makes it one of the most reliable and effective ways of NAD+ supplementation in the human body. Therefore, supplementing NR to increase NAD+ levels is very necessary to maintain our health and fight aging.
What are the health benefits of Nicotinamide riboside chloride ? (1) Anti-aging 2
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Mitochondria are organelles found in most eukaryotic cells and produce energy mainly in the form of adenosine triphosphate(ATP). The energy required by the cells of various organs in the human body comes from these mitochondria. The stronger the mitochondria, the healthier we are, and vice versa. When the function of mitochondria is weakened, it also heralds the beginning of human aging. NAD+ is the main source of energy for mitochondria, but with age, this enzyme will gradually decline, so that mitochondria cannot play an effective role. As the precursor of NAD+, NR can effectively increase the NAD+ needed in the human body, increase the level of NAD+, and then provide energy for mitochondria. In addition, it can also activate the sirtuins enzymes, which is a enzymes that can affect the lifespan and overall health of the human body. Sirtuins can repair damaged DNA, enhance stress resistance, reduce inflammation and provide other benefits that promote healthy aging. It can be seen that NR has great benefits in anti-aging. Appropriately supplementing some NRC products can make you younger and more confident. (2)Protect brain cells NAD+ can also protect brain cells from irregular degeneration, especially with age. Some studies have shown that NAD+ helps control the production of a protein called PGC-1-alpha. This protein is essential for protecting cells from oxidative stress. It can also improve and repair mitochondrial function in brain cells, thereby improving cognitive health. In experiments on mice with Alzheimer's disease, nicotinamide riboside increased 3
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brain NAD+ levels and PGC-1-α production by 70% and 50%, respectively. By the end of the study, the mice performed significantly better on memory-based tasks. In another test-tube study, researchers found that nicotinamide riboside can increase NAD + levels in stem cells of Parkinson's disease patients and significantly improve mitochondrial function. Therefore, researchers believe that oxidative stress and impaired mitochondrial function may be related to age-related brain diseases such as Alzheimer's disease and Parkinson's disease. NAD + has a positive effect on reducing the risk of Alzheimer's disease and other degenerative encephalopathy. (3)Improve heart problems Heart disease is the number one cause of death worldwide. Heart failure and myocardial infarction are common manifestations of heart disease. However, this type of disease is generally more common in the elderly, and many of them are caused by aging. Once the human body ages, it indicates that the functions of all parts of your body begin to decline, and the cells cannot supply the energy required by the organs. You may experience thickening, hardening or softening of the aortic blood vessels. Sometimes blood pressure and blood lipid levels will rise, which will increase your heart load. In animal studies, it was found that the increase in NAD + production helps reverse the potentially dangerous changes in blood arteries caused by aging. In another set of human tests, the use of nicotinamide riboside to increase the level of NAD + will help reduce aortic stiffness and lower systolic blood pressure in adults at risk of 4
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hypertension. Although this only represents the role of nicotinamide ribose chloride in reducing the cardiovascular system, it is undeniable that the use of nicotinamide ribose chloride as a possible supplement to reduce the risk of heart disease has real potential. (4)Other benefits In addition, you may discover some of the possible benefits of NRC: ●Support healthy metabolic function and help lose weight; ●Reduce cancer risk ●Support brain function, including neuroplasticity ●Support normal liver function ●Promote healthy muscle aging
Nicotinamide riboside chloride Interaction Nicotinamide riboside seems to be safe. It occurs naturally and has almost no side effects. Except for symptoms such as nausea, fatigue, headache, diarrhea, stomach discomfort and indigestion when used in high doses, no interaction effects have been found in the research with other drugs. However, its long-term role in humans is still relatively unknown.
In what forms are Nicotinamide riboside chloride sold? NRC is proven to be an enhancer of NAD in the body, and NAD+ is an important chemical for cell health and cell energy production. As we age, the content of this 5
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substance will decrease, which means that we need more energy to resist new metabolic stress. Because the reduction of NAD+ often reduces the quality of life. NRC is a supplement that can be used for anti-aging. It can be used to enhance the level of NAD+ in the human body. The U.S.Food and Drug Administration (FDA) has conducted a safety review of NR and determined that it is safe at the prescribed dose and may have great anti-aging effects. At present, there are many manufacturers of NRC on the market, mainly in the form of powders, capsules and tablets. It may appear in the form of medicine alone, or it may be added to some health foods. Sometimes you may also find it in some anti-aging skin care products. In general, taking supplements like NRC to increase energy may be beneficial. Although the reduction of mitochondria is a factor leading to aging, it is not ruled out that it is affected by other environmental factors or genetic factors. Therefore, before you try to use such supplements, you can have a comprehensive understanding of your health and choose the most suitable supplement products.
Reference [1]Chi Y, Sauve AA. Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection. Curr Opin Clin Nutr Metab Care. 2013 Nov;16(6):657-61. doi: 10.1097/MCO.0b013e32836510c0. Review. PubMed PMID: 24071780. [2]Bogan KL, Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a 6
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molecular evaluation of NAD+ precursor vitamins in human nutrition. Annu Rev Nutr. 2008;28:115-30. doi: 10.1146/annurev.nutr.28.061807.155443. Review. PubMed PMID: 18429699.
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