What will you get from Octreotide Acetate?

3. What is Octreotide Acetate used for?

Octreotide acetate raw powder has a wide range of therapeutic uses. Its physiological activities are synonymous with that of the endogenous somatostatin hormone. Take, for example, both of them inhibit secretion of growth hormone, glucagon, insulin, cholecystokinin, thyroid-stimulating hormone, and gastrin.

(1)Treatment of acromegaly

The root cause of acromegaly is excessive production of human growth hormone. If this abnormality occurs, the hypothalamus will naturally stimulate the release of somatostatin, which initiates negative feedback. However, acromegaly or gigantism will eventually develop when the body can no longer control the HGH levels.

Taking octreotide acetate inhibits the synthesis of growth hormone from the pituitary gland. This hormonal drug is more potent than the endogenous somatostatin. So, if you have misused the exogenous HGH and your gloves no longer fit, you can buy octreotide acetate to counteract the symptoms.

(2)Treatment of certain tumors

Octreotide acetate raw powder is a prescription drug for HGH-producing tumors. Ininstances where the radiation therapy fails, or surgery is not an option, the treatmentwill come in hand.

Medical practitioners recommend octreotide acetate to patients withthyrotropinoma, carcinoid syndrome, and vasoactive intestinal peptide carcinomas.In most cases, these tumors secrete excess natural hormones.

The medication not only blocks this hormone-secreting mechanism but also

suppresses the symptoms brought about by the swellings. Take, for example; octreotide acetate decreases severe watery diarrhea and flushing, which show up in patients with carcinoid and vasoactive intestinal peptide tumors.

In diarrhea, octreotide acetate injection triggers the absorption of electrolytic fluid inthe intestinal wall.

(3)Radiolabeling in Nuclear Medicine Imaging

Medics and research scientists have labeled Octreotide with several radio-nucleotides. For instance, radiolabeling the compound with lutetium-177 is a treatment for some neuroendocrine tumors.

Recently, the compound has been radiolabeled with gallium-68 and carbon-11. Thisradiolabeling has proved to be highly sensitive with excellent resolution, hence, anideal imaging method with positron emission tomography.

In octreoscan, Octreotide is labeled with indium-111 to image neuroendocrinetumors, which express somatostatin receptors.

(4) Managing Bleeding Esophageal Varices

Health providers recommend octreotide acetate to victims of liver cirrhosis with acute hemorrhaging esophageal varices. The treatment works to reduce portal venous pressure, especially in patients who have cirrhosis. It constricts the splanchnic arterioles to slow down blood flow to the portal system.

(5)Obesity

A couple of studies have suggested the efficacy of octreotide acetate inthe treatment of obesity.

Hypothalamic lesions around the hunger and satiety regions of the brain can be responsible for high BMI and obesity. Treating posterior cranial tumors or acute lymphoblastic leukemia with radiotherapy or surgery can injure the hypothalamus.

As a result, this part of the brain will no longer be responsive to energy balance signals. Eventually, there will be an increase in vagal activity, insulin hypersecretion, and adipose deposition. Besides, the body will take in more calories than it requires, leading to abnormal weight gain.

Taking octreotide acetate injection suppresses the excessive release of insulin andthe build-up of adipose tissues. In a particular clinical trial involving 18 patients with

hypothalamic dysfunction, the research scientists found out that octreotide acetate

lowered the BMI of the subjects relative to the placebo.

(6) Treatment of Gastrointestinal Fistula

The octreotide acetate injection limits the gastrointestinal secretions by reducing itsmotility.

Other medical applications of this somatostatin agent include;

Treatment of hypoglycemia in both neonates and adults

Decreasing insulin hypersecretion

Management of chronic refractory hypotension

Reversing peripheral vasodilation when used alongside midodrine

Managing idiopathic intracranial hypertension

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