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The Ultimate Guide Of Tadalafil
Overviews Erectile dysfunction is a common sexual arousal disorder in males affecting approximately 52 percent of men over the age of 18 years, worldwide. Varying in intensity, erectile dysfunction is usually caused by decreased blood flow to the penile blood vessels, which is the main step in the production of an erection. Erectile dysfunction is a completely manageable and curable disorder with different medications targeting specialized enzymes in the wall of the penile blood vessels. One of the most potent medications for ED is Tadalafil powder with a half-life of 17.5 hours.
What is Tadalafil Powder? Tadalafil Powder belongs to the sexual stimulants class of drugs as it is a medication designed for men over the age of 18 years, suffering from erectile dysfunction. Tadalafil, or (6R-trans)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1＇, 2＇ :1,6]pyrido[3,4-b]indole-1,4-dione is a drug similar to Sildenafil or Viagra, in action, but different in structure. Tadalafil also differs from the common erectile dysfunction medication, Viagra, in potency as it is more potent and efficient than the latter.
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Tadalafil Powder is a PDE5 inhibitor drug, which means that it targets the PDE5 enzyme found in the smooth muscle cells of the penile blood vessels. The inhibitory function of the medication is quite beneficial as the main purpose of the enzyme is to cause vasoconstriction, which in penile blood vessels, results in decreased blood flow and consequently erectile dysfunction. Tadalafil Powder is manufactured by Pharmax Lifesciences and can be used for the treatment of more than just erectile dysfunction. Tadalafil Powder is also prescribed to men suffering from benign prostatic hyperplasia and even pulmonary arterial hypertension. However, Tadalafil Powder is ineffective in the treatment of other sexual arousal disorders in males and females.
Forms of Tadalafil Tadalafil is a potent PDE5 inhibitor, available in different forms and dosages, making its consumption easier for patients. The medication is available in the form of pills or capsules, with the dosage being 5 mg, 10 mg, and 25 mg. It is important to note that the dosage of Tadalafil differs based on the manufacturing company. Tadalafil is also available in powder form, although it is mostly sold for industrial use. This is the main reason behind Tadalafil Powder wholesale shopping being quite famous with this form of the drug. This form is usually sold in containers of 25 kg to 50 kg, depending on the wholesale requirement. The general dosage for Tadalafil powder, to start with, is 10 mg. The maximum dosage, within 24 hours, is 20 mg, and exceeding this dosage is not recommended. This medication is safe for human consumption as it has received FDA approval and approval from Indian, Canadian, Australian, and British Health authorities. The FDA approved the use of Tadalafil pills in the year 2002, and soon after, tadalafil powder use was approved by FDA as well. Tadalafil powder manufacturer factory claims to manufacture the prescription-only medication with utmost precision. The manufacturers have the highest regard for human safety, which is made abundantly clear in the potency, safety, and efficacy of the final product.
How does Tadalafil Powder Work? Tadalafil Powder contains Tadalafil, a PDE5 inhibitor compound that was initially researched and manufactured by GlaxoSmithKline after the discovery of Sildenafil, a similar compound. Sildenafil, on the other hand, was initially being researched as a treatment for angina and hypertension but the whole study was scrapped after failed results in the early phases of the study. However, upon review, it was found that Sildenafil may be able to produce erections if the patients were properly sexually stimulated. As sildenafil is a PDE5 inhibitor, GlaxoSmithKline decided to perform a wide-range search into compounds with a similar mechanism of action as Sildenafil. This research led to the discovery and then the development of Tadalafil.
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Tadalafil is a potent PDE5 inhibitor with a half-life of 17.5 hours that takes approximately 96 hours to completely clear out of the human body. When compared to the common blue pill, Viagra, which is only effective for 3 hours to 4 hours after ingestion, Tadalafil comes out on the top. The main mechanism of action of the drug is inhibiting the PDE5 enzyme that is present in the smooth muscle cells of the penile blood vessels. Inhibition of this enzyme results in vasodilation and eventually, increased blood flow through the blood vessels, which are surrounded by corpus cavernosa. This muscle of the penis, when put under strain by increased blood flow, is pressured into an erect position, which is referred to as an erection. However, the penile muscles, corpus cavernosa to be exact, need to initially relax so the blood vessels can dilate and receive a high input of blood. This relaxation of the smooth muscles is also the effect of inhibition of the PDE5 enzyme, although indirectly. Inhibition of PDE5 results in an increased amount of Guanosine MonoPhosphate or GMP, which is important for the relaxation of smooth muscles, such as corpus cavernosa. However, that is not the only use and mechanism of action of Tadalafil Powder. The prescription-only medication is also used for benign prostatic hyperplasia, a urinary disorder caused by enlargement of the prostate gland and presenting as painful urination. The mechanism of action for the treatment of enlarged prostate gland is also through the increased levels of GMP in the smooth muscle cells. Relaxation of these cells allows easier passage of urine and prevents urine retention and pain. Tadalafil Powder is also prescribed for pulmonary arterial hypertension, as the PDE5 inhibiting effect not only increases the blood flow but also decreases the blood pressure, which is extremely beneficial in the treatment of PAH.
What Can Tadalafil Powder be Used For? Tadalafil Powder is used for the treatment of the following conditions:
Erectile Dysfunction Benign Prostatic Hyperplasia Pulmonary Arterial Hypertension
Although research is being conducted on new potential uses of the medication, currently it is only meant to be prescribed to men over the ages of 18 years, suffering from one of the disorders mentioned above. Most commonly, the medication is used for the treatment of erectile dysfunction.
Benefits of Tadalafil Powder Tadalafil has several benefits both on its own and when compared to other PDE5 inhibitors belonging to the class of sex stimulants drugs. This medication is potent and long-lasting as it takes 36 hours to be cleared from the system, only being virtually untraceable after 96 hours. The effects of the drug become apparent and visible around 20 minutes to 60 minutes after ingestion, and Tadalafil powder stays active for about 3 hours to 4 hours after. It is
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important to mention that the activity of the drug does not in any way equate to the duration of the erection. Tadalafil Powder is incapable of producing spontaneous erections and needs appropriate sexual stimulation and arousal for it to be effective in producing an erection. If sexual stimulation is provided during the four hours following the ingestion of the medication, the drug can produce an erection and alleviate the symptoms of erectile dysfunction. This sex stimulant drug is quite effective in treating erectile dysfunction as a result of its prolonged mechanism of action, which makes it the drug of choice for many suffering from erectile dysfunction and benign prostatic hyperplasia. Tadalafil Powder may be combined with Tamulsin, another potent drug for the treatment of benign prostatic hyperplasia although the efficacy of this drug mixture is still being studied and analyzed.
Appropriate Dosage of Tadalafil Powder Tadalafil Powder, as mentioned above, is usually started off at 10 mg as the lowest dose possible. After at least a week of using the medication, the dose may be reduced, increased, or maintained at the same levels depending on the results. However, it is important to keep in mind that this medication is a prescription-only medication that should only be used when needed. It should also only be used once in 24 hours so as to not amplify the side effects of the medication. The risk of a missed dose for a medication that should only be taken when needed is almost non-existent however, it is important to clarify the guidelines for a missed dose. This is because the medication is prescribed for daily use, at least three times a day when being used for the treatment of pulmonary artery hypertension and benign prostatic hyperplasia. In case of a missed dose, it is best to avoid that dosage completely, and under no circumstances should a missed dose be compensated with a double dose next time. This could lead to extremely prolonged and undesired effects that have the potential to result in nearly fatal complications.
Who Should Not Use Tadalafil Powder Tadalafil Powder has various benefits and uses but it is specifically designed for the male gender, especially those over the age of 18 years. The medication should not be taken by women and children as they may be at higher risk of developing several of the common side effects and complications associated with Tadalafil Power use. The following populations should not take Tadalafil Powder, or consult with their doctor before starting any medication belonging to the PDE5 inhibitors drug class:
People with a history of surgical intervention within the last three months People with a history of cardiac events in the last three months to six months People with hypertension and hyperlipidemia People with renal diseases People with retinitis pigmentosa People with hemophilia or similar blood disorders
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People with multiple myeloma, or leukemia People with stomach ulcers People with a history of stroke or with increased risk of suffering a stroke
These people aren’t allowed to take Tadalafil because their current medications can interact with the drug, resulting in life-threatening complications. In some cases, these patients’ bodies may be more susceptible to the relatively common and non-serious side effects of the drug but the intensity of complications may be higher than usual.
Potential Side Effects of Tadalafil Powder Tadalafil Powder, like most medications, has several common side effects associated with its use. However, none of them are serious, daily-life activities altering, or life-threatening. In fact, most of them will resolve on their own and will not require medical intervention. The common side effects of Tadalafil include, but are not limited to:
Stuffy nose Headaches Dyspepsia Stomach ache Flushing; warmth and redness of the skin Tinnitus; persistent ringing sound in the ear Hearing problems Blurry vision Loss of vision Priapism
The last side effect is relatively more serious and refers to a prolonged and painful erection that has lasted, usually more than four hours. In such situations, it is recommended to seek medical help immediately as it is a more serious, albeit rare, side effect of Tadalafil consumption. Since October of 2007, FDA requires all PDE5 inhibitor drugs containers to include a warning label that lets the users know that these medications have the potential to cause temporary yet sudden hearing loss. This decision by the FDA was the result of several complaints of hearing loss in patients using Tadalafil or similar drugs that were registered with the FDA, requiring them to properly analyze the issue. FDA research found hearing loss to be a serious side effect of TAdalafil that they believe all patients should be made aware of, in clear terms, so they can make an informed decision. Vision loss was yet another frequent complaint associated with Tadalafil use and when FDA looked into these complaints, it was found that this side effect was mostly occurring in patients already suffering from an eye pathology, namely non-arteritic anterior ischemic optic neuropathy or NAION. Since there was no direct cause and effect found by the FDA, there is no warning label related to vision loss on Tadalafil powder or other PDE5 inhibitors packing labels.
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Common Drug Interactions with Tadalafil Powder Certain medications should not be taken together as they can interact with each resulting in either decreased effect of both, the increased effect of both, or amplification of negative effects of both medications. Tadalafil Powder is one such medication that should not be taken along with the following medications. Antacids: These medications interact with Tadalafil such that they result in decreased efficiency of the latter drug, although the exact mechanism is yet not understood. However, it is important to warn patients about the possible interaction between these two medications, especially as the former drug is a common household medication. PDE5 Inhibitors: Consumption of drugs with a similar mechanism of action as Tadalafil can result in a significant increase in blood flow and a life-threatening decrease in blood pressure. Mixing two different PDE5 inhibitors or taking a double dose of the same drug can result in complications rather than extra benefits. Alcohol: Taking Tadalafil powder with alcohol cannot cause any specific complications but it can result in a huge increase in the intensity of the side effects. They may be common in occurrence but when intensified, can become intolerable and may require medical help. Nitrates: These medications are used for cardiac purposes and their main function is to increase blood flow through blood vessels by having a vasodilatory effect on them. This mechanism of action is similar to that of Tadalafil, hence the combination of the two drugs results in an exaggeration of the negative effects of both drugs. Anti Hypertensives: The reason for this is the same as that of nitrates. Anti hypertensives and Taladafil both work on reducing blood pressure by vasodilating vessels, which if taken together, would result in extremely low blood pressure that could result in mortality, if left untreated. CYP3A4 Inducers: CYP3A4 is the enzyme responsible for the excretion of the Tadalafil compound from the body after it has served its purpose. However, a medication that increases the effects of this enzyme would consequently result in increased excretion of Tadalafil, even before it has been able to fulfill its purpose. This renders the latter inefficient and useless. CYP3A4 Inhibitors: Any drug that inhibits the action of the CYP3A4 enzyme would result in decreased excretion of Tadalafil which would leave it in the human system longer than necessary. This prolonged effect is unnecessary and has the potential to be quite dangerous overall, which is why the combination of these two should be avoided at all costs. Guanylate Cyclase Stimulators: These medications target the vasculature of the lungs, aiming to reduce the pressure of the blood flowing through it. However, that is also one of the beneficial effects and uses of Tadalafil. Taking these two together could result in extremely low pulmonary blood pressure, which can be fatal if not aptly and timely treated.
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Where is Tadalafil Powder Sold? Tadalafil Powder wholesale trades are much more common than retail sales as it is usually purchased in bulk directly from the Tadalafil Powder manufacturer factory. Generally, medications of such private nature are commonly bought online as it provides patients with discretion and privacy that they need. The medication is available in almost all of the local and online pharmacies but patients need to have a prescription to be able to buy it.
Further Medical Research and Information Tadalafil is constantly being researched and studied to assess any other potential use of the medication. Tadalafil is the key compound in many different prescription drugs, all being sold under different brand names, mostly for disorders such as erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. However, there are various studies that in their first phases have shown that Tadalafil, in the future, may be prescribed for other disorders as well. One of the most important studies being performed on Tadalafil focuses on its efficacy and safety if used daily by patients suffering from erectile dysfunction. The study was published in an Indonesian Health Journal, and based on the researchers’ analysis of literature from electronic databases, it concluded that using Tadalafil once a day is more effective in treating erectile dysfunction than only using the medication when needed. The reason why this study is so important is that it has the potential to change the treatment protocols for erectile dysfunction. However, further studies need to be performed before a change can be made in the treatment plans. Another research into Tadalafil aims to repurpose the sex stimulant drug, along with a drug belonging to the same class, vardenafil, to be used in the treatment of bone disorders. The bone disorders here refer to disorders where osteoclast or bone-destroying cells are functioning at a higher speed and with efficiency unmatched to the functioning of the osteoblast or bone-forming cells. This results in decreased bone mass which makes patients susceptible to pathologic fractures. The in vivo phase of the study showed that both of these drugs can not only increase the activity of osteoblasts but simultaneously decrease the activity of osteoclasts. The drugs are able to do this because the PDE5A pathway is key in producing a balance of both types of cells. The same pathway is what the drugs target for the treatment of erectile dysfunction. After the application of in vivo concepts on animal models by researchers leading this study, it was found that both drugs are viable options for the management of a healthy bone mass. However, further studies need to be conducted on the effects of both of the drugs on the bone mass of humans. A meta-analysis published in the Endocrinology Journal compared the efficacy of tadalafil treatment, tamsulosin treatment, and tamsulosin plus tadalafil treatment in aiding the expulsion of urethral stones. The aim of the study was to not only find new combination therapies to help patients with ureteral stones but to also assess the safety of these treatment plans.
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The use of tadalafil alone or tadalafil with tamsulosin were the two options that were found to be the most effective and least likely to produce an adverse effect. Moreover, the analgesic effects of Tadalafil may be able to alleviate the pain most patients with ureteral stones experience while the drug also helps expel the stone out of the system.
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