What are the benefits of Nicotinamide mononucleotide (NMN)? NMN supplements have the potential to fight aging, ward off chronic disease and heighten your energy levels. When we boost NMN levels in the body, we can enhance the biosynthesis of NAD+ and alleviate symptoms associated with depletion of this crucial nutrient. In fact, NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, neurological function, heart health, insulin sensitivity, dyslipidemia, body weight, and gene expression. By taking NMN supplements, you may reap benefits that include:
Increased bone density and muscle Decreased physical endurance and muscle strength are often considered to be “inevitable” symptoms of the normal aging process. However, recent animal research indicates that mice treated with NMN had stronger muscles and bones. Reversing Aging As NMN and NAD both activate the SIRT1 longevity gene, these Washington University researchers observed marked activation of longevity genes and suppression of aging genes. Chronic health complications always accompany the process of aging. As the body undergoes several physiological changes, some of the cellular functions happen to fall back. Take, for example, the levels of nicotinamide adenine dinucleotide(NAD+) decreases in multiple organs, leading to a decline in energy production by the cell’s mitochondrion. Aging sets in motion various factors such as damaging of the DNA due to uncharged molecules, vascular oxidative stress, and other cognitive disorders. Body weight, energy metabolism, blood lipids, insulin sensitivity, and vision are also adversely affected by the aging process. Excitingly, NMN supplementation has been found to suppress age-associated weight gain, enhance metabolism, improve insulin sensitivity and plasma lipid levels, benefit vision, and prevent adverse alterations in gene expression in aging mice. These effects highlight the therapeutic potential of NMN as a beneficial anti-aging intervention for humans. Alzheimer’s Disease and Neurological Function A reduction in the levels of NAD+ in the brain interferes with cognitive health among the elderly. Administration of NMN accelerates NAD+ production, hence, protecting the neural functions.
Nicotinamide mononucleotide (NMN) may help bolster the beneficial effects of dietary and lifestyle changes in Alzheimer’s disease prevention by preserving the health of the brain. NMN inhibits the buildup of amyloid-beta, an abnormal protein implicated in the adverse brain changes characteristic of Alzheimer’s disease, while also decreasing synaptic loss and brain inflammation. These effects slow down the process of brain degeneration and may even help reverse the progression of Alzheimer’s disease. The neurological benefits of Nicotinamide mononucleotide (NMN) are not limited to Alzheimer’s disease; NMN also maintains the brain’s population of neural stem cells and attenuates brain injury after head trauma. These findings suggest that NMN may have significant therapeutic benefits for athletes who have suffered concussions, and other individuals recovering from head injuries. Protects Against Heart Disease The mitochondria is the energy power plant of cells. In this study, mice given NMN were much more energetic and had better energy production from their mitochondria. The human heart requires a continuous supply of ATP to fuel its muscular contractions and sustain life. Interruptions in the heart’s ATP supply can impair cardiac and vascular function and contribute to the development of cardiovascular disease. By enhancing the biosynthesis of NAD+, an essential substrate in ATP-producing reactions, NMN boosts cardiac ATP levels and significantly improves heart health. In fact, supplementation with NMN may even prevent myocardial infarctions and heart failure! Importantly, NMN also reduces arterial aging and vascular dysfunction, two phenomena that play crucial roles in the pathogenesis of cardiovascular disease.
Less diabetes In pancreatic beta cells, NAD+ regulates insulin secretion in response to the ingestion of dietary glucose. NAD+ also governs insulin activity and glucose homeostasis in skeletal muscle, the liver, and adipose tissue. Research indicates that the normal biosynthesis of NAD+ is severely compromised in diabetic individuals, leading to insulin resistance and glucose intolerance. By restoring NAD+ levels in skeletal muscle, the liver, and adipose tissue, NMN improves insulin sensitivity and may help reverse the course of diabetes. After administering a daily dose of NMN for close to 10 days, the scholars established that the mice, which were subjected to high-fat meals, recorded improved insulin intolerance. Mice on NMN showed much better insulin sensitivity. Better insulin sensitivity means less diabetes.
Enhances Maintenance of DNA Repair The NAD+ made from NMN activates a group of proteins called sirtuins. Sirtuins, sometimes thought of as the guardians of our healthspan, play a key role in maintaining DNA integrity. Each time our cells divide, the DNA at the very ends of our chromosomes grows a tiny bit shorter. At a certain point, this begins to damage our genes. Sirtuins slow this process by stabilizing those end
bits, known scientifically as telomeres. In order to function, however, sirtuins rely upon NAD+. Recent studies have shown that feeding mice NMN activated sirtuins and led to more stable telomeres. Lower body weight The pathological mechanism of obesity and diabetes are correlated. Low NAD+ levels bring about mitochondrial dysfunction; hence, a decrease in the production of ATP. Obesity weighs down the potential of the mitochondria in generating ATP energy for the cells. Once you administer Nicotinamide Mononucleotide, the drug will improve glucose intolerance and other metabolic functions relating to obesity. In this study, mice fed low-dose NMN lost 4% of their body weight. Those fed high-dose NMN lost 9% of their body weight. Better immune system function As adults get older the immune system declines, people get ill more easily, and it becomes harder for people to bounce back from illnesses such as the seasonal flu, or even COVID-19. Recent studies have suggested that NAD+ levels play an important role in regulating inflammation and cell survival during the immune response and aging. The study underscored the therapeutic potential of NAD+ for immune dysfunction. Nicotinamide mononucleotide (NMN) treated mice showed better immune function. Better functioning of the immune system means less infections and and less cancer.
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[6] Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. Yamamoto T, Byun J, Zhai P, Ikeda Y, Oka S, Sadoshima J. [7] Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer's disease-relevant murine model. Long AN, Owens K, Schlappal AE, Kristian T, Fishman PS, Schuh RA. BMC Neurol. 2015 Mar 1;15:19. doi: 10.1186/s12883-015-0272-x. [8] Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects. Kiss T, Giles CB, Tarantini S, Yabluchanskiy A, Balasubramanian P, Gautam T, Csipo T, Nyúl-Tóth Á, Lipecz A, Szabo C, Farkas E, Wren JD, Csiszar A, Ungvari Z.