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What does 5-alpha-hydroxy laxogenin do？
5-alpha hydroxy laxogenin is the most similar to sex hormones that are synthesized from cholesterol in the human body. These sex hormones that are found naturally in the human body act on nuclear receptors, whereas the 5a hydroxy laxogenin attaches to a cellular receptor, on the surface of the cell.
Many companies that have 5a hydroxy laxogenin powder for sale often sell this supplement with the advertisement that it has up to 200 percent potency and can improve muscle tone amongst athletes significantly. These claims made by different manufacturers are the result of several studies that have been performed with the purpose of assessing muscle-mass enhancement properties of laxogenins.
A recent Russian research on animal models found that thermogenic compounds derived from the same group of plant hormones as laxogenin, with the same effects as laxogenin. According to this study, these brassinosteroid derivatives were able to increase the protein content of liver, heart, kidney, and leg muscles. Moreover, researchers found that these derivatives did not produce these benefits by replicating or mimicking the effect of sex hormones in the human body.
Another research study that was also performed on animal models and used
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Xuchang shangke Chemical Co., Ltd
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hormones belonging to the same class of plant hormones as laxogenin was able to replicate the same results as the Russian study. Multiple other pieces of research were conducted to ensure the legitimacy of these results and the results were found to be easily replicated, hence, guaranteeing their potency and efficiency.
It is important to point out that while many users of 5a hydroxy laxogenin powder claim to see the results that the vendors have advertised, finding concrete scientific evidence to support their use has been difficult. Most of the studies are performed on animal models and use compounds that either belong to the brassinosteroid class of hormones or a similar plant hormone, phytoecdysteroids. Laxogenins are similar to these hormones and 5a hydroxy laxogenin is a derivative of laxogenins, but that does not guarantee the same benefits seen with the other hormones.
One study that was performed using natural and synthetic laxogenin in a laboratory setting found that this powder could reduce oxidative stress in the body significantly. Reduction of oxidative stress by laxogenins was performed by reducing free radicals, a type of harmful substance in the body that can participate in different chemical reactions and harm the body markedly. This reduction in free radicals and oxidative stress can explain how 5a hydroxy laxogenin powder is able to improve muscle recovery, post-workout. However, this study has to be performed on both animal models and human subjects before the results of the study are widely believed.
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Xuchang shangke Chemical Co., Ltd
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All of the above-mentioned studies were performed with the purpose of finding out if laxogenins would be able to increase muscle mass and tone. However, the only use of 5 alpha-hydroxy laxogenin isn’t bodybuilding and that is what some of the other pieces of research were hoping to prove.
In two separate studies, the use of 5-alpha-hydroxy laxogenin powder in colon cancer patients reduced the size of cancer significantly. Similarly, lung cancer development was found to be reduced with the use of 5a hydroxy laxogenin powder in animal models. While these studies aren’t able to provide the conclusive evidence that is required for any supplement or medication to be included in the treatment protocol, they are a step in the right direction.
References: 1. Illegal Ingredient, 5-Alpha-Hydroxy-Laxogenin, Appearing in More Supplements. Education, Spirit of Sport / December 4, 2019 2. Bioorg Med Chem. 2012 Apr 15;20(8):2690-700. doi: 10.1016/j.bmc.2012.02.026. Epub 2012 Feb 15. New insights into the structure-cytotoxicity relationship of spirostan saponins and related glycosides. Karell Pérez-Labrada, Ignacio Brouard, Sara Estévez, María Teresa Marrero, Francisco Estévez, Jaime Bermejo, Daniel G Rivera. PMID: 22405922 3. Y W Zhang, I Morita, L Zhang, G Shao, X S Yao, S Murota. Screening of anti-hypoxia/reoxygenation agents by an in vitro method. Part 2: Inhibition of 3
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tyrosine kinase activation prevented hypoxia/reoxygenation-induced injury in endothelial gap junctional intercellular communication. Planta Med. 2000 Mar;66(2):119-23. doi: 10.1055/s-2000-11126. PMID: 10763583 4. Diana M. Cheng, Louis W. Kutzler, Dustin D. Boler, Jenny Drnevich, John Killefer, and Mary Ann Lilaa. Continuous Infusion of 20-Hydroxyecdysone Increased Mass of Triceps Brachii in C57BL/6 Mice. Published online 2012 Apr 12. doi: 10.1002/ptr.4679. PMC3410052 5. Debora Esposito, Slavko Komarnytsky, Sue Shapses, and Ilya Raskin. Anabolic effect of plant brassinosteroid. FASEB J. 2011 Oct; 25(10): 3708 – 3719. doi: 10.1096/fj.11-181271. PMC3177571
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