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Product Name
Chenodeoxycholic acid
Chemical Name
(R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-1 0,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanth ren-17-yl)pentanoic acid
Synonym
Chenodeoxycholic Acid; Anthropodeoxycholic acid; Anthropodesoxycholic acid; CCRIS 2195; Chendol; chenic acid; Chenix; Chenodeoxycholic acid; Chenodesoxycholic acid; Chenodiol; Gallodesoxycholic acid; NSC 657949; Xenbilox
CAS Number
474-25-9
InChIKey
RUDATBOHQWOJDD-BSWAIDMHSA-N
Molecular Formula
C24H40O4
Molecular Weight
392.57
Monoisotopic Mass
392.29265975
Melting Point
165-167 °C (lit.)
Boiling Point
437.26°C (rough estimate)
Density
0.9985 (rough estimate)
Color
White to off-white
Solubility
PRACTICALLY INSOLUBLE
Storage Temperature
room temp
Application
Chenodeoxycholic acid has been used in a study to assess its effects as a long-term replacement therapy for cerebrotendinous xanthomatosis (CTX). It has also been used in a study to investigate its effects on the small-intestinal absorption of bile acids in patients with ileostomies.
Testing Report
Available
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Phcoker
Xuchang shangke Chemical Co., Ltd
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History Chenodeoxycholic acid is a bile acid synthesized in the liver from cholesterol. Chenodeoxycholic acid was isolated in 1924 from goose gall by Adolf Windaus and human gall by Heinrich Wieland.Its complete structural configuation was elucidated by Hans Lettre at the University of Gottingen.
In 1968, William Admirand and Donald Small at Boston University Medical School established that it was then found that biliary levels of cholic acid and chenodeoxycholic acid were lower in patients with cholesterol gallstones than in normal people. And then the national collaborative study in the United States, which confirmed the effectiveness of chenodeoxycholic acid in bringing about dissolution of gallstones in selected patients. However, recent developments such as laparoscopic cholecystectomy and endoscopic biliary techniques have curtailed the role of chenodeoxycholic acid and ursodeoxycholic acid in the treatment of cholelithiasis. In 1978, chenodeoxycholic acid was introduced to the European market as the 7α isomer of ursodeoxycholic acid. From 2010 to 2018, chenodeoxycholic acid was approved for the treatment of cerebral tendon xanthomatosis.
While many other benefits of chenodeoxycholic acid have yet to be proven by research, large-scale clinical trials have demonstrated the drug's safety and efficacy. And it was the first drug to be introduced into the U.S. market for the treatment of light-transmitting gallstones. 2
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What is Chenodeoxycholic Acid(CDCA) Powder? Chenodeoxycholic acid powder (3α,7α-dihydroxy-5-β-cholanic acid, CDCA) is one of the major bile acids synthesized from cholesterol in the liver of humans and animals. It was originally isolated from the bile of domestic geese, hence the name "cheno". It was the first drug introduced to the US market for the treatment of light-transmitting gallstones.
As a hydrophobic primary bile acid naturally occurring in the body, chenodeoxycholic acid activates nuclear receptors (FXRs) involved in cholesterol metabolism. It dissolves cholesterol that causes gallstones and inhibits cholesterol production in the liver and intestinal absorption, which can help reduce gallstone formation. When bile acid levels are elevated, it can also reduce the amount of other bile acids that are harmful to liver cells.
Chenodeoxycholic acid is also the epimer of ursodeoxycholic acid (DB01586) and has similar efficacy to ursodeoxycholic acid in the treatment of gallstone disease.
Chenodeoxycholic acid has been studied and evaluated as a long-term replacement therapy for cerebral tendon xanthoma (CTX). It has also been used to study its effect on the intestinal absorption of bile acids in ileostomy patients.
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Where Does The Chenodeoxycholic Acid Powder Come From? Chenodeoxycholic acid is the main organic constituent in the bile of chickens, ducks, geese and other poultry. It can be extracted from poultry bile by extraction technology or synthesized from cholic acid, dehydrocholic acid, etc. Originally, the synthesis of chenodeoxycholic acid (CDCA) from cholic acid(CA) was the main source of CDCA.
In Europe, chemical synthesis of CDCA from CA is the main source of CDCA. In the past 10 years in my country, the extraction of CDCA from chicken bile is the main source of CDCA. Although the number of chickens and ducks in China is very large, the extraction of CDCA from chicken and duck gallbladder requires different techniques due to the large differences in the composition of chicken and duck gallbladder. The method of extracting CDCA from duck bile is rarely reported in the literature.
Chenodeoxycholic Acid Powder Mechanism of Action Chenodeoxycholic acid is a primary bile acid synthesized by the human liver, and it can inhibit the synthesis of cholesterol and bile acid in the liver, gradually replacing the latter and its metabolite deoxycholic acid in the expanded bile acid pool. These actions contribute to desaturation of bile cholesterol and progressive dissolution of radiolucent cholesterol gallstones in the presence of the gallbladder revealed by oral 4
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cholecystography. Bile acids can also bind to the bile acid receptor (FXR), which regulates bile acid synthesis and transport.
The Benefits & Effects of Chenodeoxycholic Acid Powder Chenodeoxycholic acid is a bile acid synthesized from cholesterol in the liver, and it has significant anti-inflammatory, antitussive, and expectorant effects. In addition, CDCA powder has the following potential benefits for the human body: - Can reduce or dissolve cholesterol stones in the body - Improve the composition of bile - For the treatment of cerebral tendon xanthomatosis - Drug therapy for metabolic diseases - For the treatment of various acute and chronic liver diseases
It is important to note in the treatment of gallstones that chenodeoxycholic acid is primarily used to dissolve gallstones in people who cannot have gallbladder surgery.
Drug Interactions of Chenodeoxycholic Acid Powder Although chenodeoxycholic acid is effective in treating or preventing cholesterol stones diseases, it may be a interaction with other drugs (including prescription and over-the-counter drugs, vitamins and herbal products) when used together. Therefore, before using chenodeoxycholic acid, tell your doctor about all medicines you are currently using and any medicines you start or stop using, especially: 5
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- cholestyramine; - Colestipol; - cyclosporine and sirolimus - Phenobarbital - Birth control pills or hormone replacement therapy; - Aluminum-containing antacids - Almacone, Gelusil, Maalox, Mag-al Plus, Mylanta, Rulox, etc.; - Blood thinners - warfarin, coumarin, yantovin.
The above is just a short list of drugs. Therefore, it is best to check with your doctor or pharmacist before giving any prescription medicine.
Ursodeoxycholic Acid Powder VS Chenodeoxycholic Acid Powder Both Ursodeoxycholic acid and chenodeoxycholic acid are one of the bile acids in bile, and chenodeoxycholic acid is also the epimer of Ursodeoxycholic acid. They have their own unique advantages, but in some ways their efficacy is similar. (1)Definition Ursodeoxycholic acid powder Ursodeoxycholic acid(UDCA; also known as ursodiol) is a secondary bile acid that is metabolized by gut bacteria in humans and most other species. It is synthesized in the liver of some species and was originally found in bear bile, which is where its 6
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name Ursus comes from.
Chenodeoxycholic acid powder Chenodeoxycholic acid (CDCA; also known as chenodesoxycholic acid, chenocholic acid and 3α,7α-dihydroxy-5β-cholan-24-oic acid) is a bile acid. Salts of this carboxylic acid are called chenodeoxycholates. Chenodeoxycholic acid is one of the main bile acids. It was first isolated from the bile of the domestic goose, which gives it the "cheno" portion of its name.
(2)Benefits&functiion Commonality Ursodeoxycholic acid powder and chenodeoxycholic acid powder are both bile acids, both used to treat gallstones in people who cannot have gallbladder surgery. They are not effective in patients with calcified gallstones or a non-functioning gallbladder.
Difference Ursodeoxycholic acid powder is a hydrophilic secondary bile acid naturally found in human bile in small amounts (less than 4% of total bile acids). It was first introduced in the 1970s to dissolve radiolucent gallstones and is the only drug approved by the U.S. Food and Drug Administration for the treatment of PBC. UDCA is more hydrophilic than other bile acids such as chenodeoxycholic acid and deoxycholic acid. Its absorption (3-60% after oral administration) occurs primarily in the small intestine, 7
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and its presence reduces cholesterol secretion into bile, possibly reducing its conversion to bile acids. Collectively, the mechanism of action of UDCA in PBC is based on alterations in bile acid pools, reductions in pro-inflammatory cytokines, and effects on apoptosis and vasoactive mediators.
Chenodeoxycholic acid is a hydrophobic primary bile acid, an epimer of UDCA, synthesized in the liver and present in bile at high concentrations for the dissolution of cholesterol gallstones. It is most effective for small "floating" gallstones. Chenodeoxycholic acid was approved in 1983 for patients with light-transmitting gallstones and is still available, although it has largely been seen as more effective and well-tolerated Better chenodeoxycholic acid substitution. In addition, it is used to treat cerebral tendon xanthomatosis. It has been studied as a possible treatment for constipation and has been shown to speed up colonic transit and improve bowel function.
The Side effects of Chenodeoxycholic Acid Powder In addition to its desired effects, chenodeoxycholic acid powder may cause some adverse effects. Although not all of these side effects can occur, if they do occur, they may require medical attention. If any of the following side effects occur, consult your doctor immediately:
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Serious side effects may include: - Signs of an allergic reaction (eg hives; difficulty breathing; swelling of the face, lips, tongue or throat, etc.) - Worsening or no improvement of gallstone symptoms; - Severe or persistent diarrhea; - Liver problems - loss of appetite, upper abdominal pain, tiredness, easy bruising or bleeding, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
Common side effects may include: - Mild stomach cramps - Gastrointestinal discomfort - Diarrhea - Bloating - Indigestion - Nausea and vomiting - Abnormal blood tests (low white blood cells, high cholesterol or triglycerides)
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist or suppliers.
Where is Chenodeoxycholic Acid Powder Sold? Chenodeoxycholic acid powder wholesale trades are much more common than retail 9
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sales as it is usually purchased in bulk directly from the Chenodeoxycholic Acid Powder manufacturer factory. Generally, medications of such private nature are commonly bought online as it provides patients with discretion and privacy that they need. And maybe you can find it at your local pharmacy, usually in tablet and capsule form. But whether you buy it online or pharmacy, you should take care to take the appropriate dose as recommended by your supplier or doctor, and should not be missed or overdose.
Reference: [1] Russell DW (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annu. Rev. Biochem. 72: 137–74. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708. [2] Bhagavan, N.V.; Ha, Chung-Eun (2015). "Gastrointestinal Digestion and Absorption".
Essentials
of
Medical
Biochemistry.
pp.
137–164.
doi:10.1016/B978-0-12-416687-5.00011-7. ISBN 9780124166875. [3] Dawson, PA; Karpen, SJ (June 2015). "Intestinal transport and metabolism of bile acids". Journal of Lipid Research. 56 (6): 1085–99. doi:10.1194/jlr.R054114. PMC 4442867. PMID 25210150. [4] Carey MC (December 1975). "Editorial: Cheno and urso: what the goose and the bear
have
in
common".
N.
Engl. 10
J.
Med.
293
(24):
1255–7.
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doi:10.1056/NEJM197512112932412. PMID 1186807. [5] Berginer VM, Salen G, Shefer S (December 1984). "Long-term treatment of cerebrotendinous xanthomatosis with chenodeoxycholic acid". N. Engl. J. Med. 311 (26): 1649–52. doi:10.1056/NEJM198412273112601. PMID 6504105. [6] Rao, AS; Wong, BS; Camilleri, M; Odunsi-Shiyanbade, ST; McKinzie, S; Ryks, M; Burton, D; Carlson, P; Lamsam, J; Singh, R; Zinsmeister, AR (November 2010). "Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis". Gastroenterology. 139 (5): 1549–58, 1558.e1. doi:10.1053/j.gastro.2010.07.052. PMC 3189402. PMID 20691689. [7] Thistle JL, Hofmann AF (September 1973). "Efficacy and specificity of chenodeoxycholic acid therapy for dissolving gallstones". N. Engl. J. Med. 289 (13): 655–9. doi:10.1056/NEJM197309272891303. PMID 4580472. [8] Hofmann, AF (September 1989). "Medical dissolution of gallstones by oral bile acid
therapy".
American
Journal
of
Surgery.
158
(3):
198–204.
doi:10.1016/0002-9610(89)90252-3. PMID 2672842.
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