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New Products Hazardous fume prevention Scientists, chemical hygienists and researchers who work with highperformance liquid chromatography (HPLC) and similar liquid-based technologies will require reliable protection against harmful chemical vapours in the laboratory. This can be done with VapLock Closed Systems for solvent delivery and waste containment. They safeguard technicians and the environment and help maintain compliance with government safety regulations and laboratory best practices. The systems also regulate solvent extraction, maintain pressure equilibrium and control evaporation of the mobile phase, facilitating more repeatable analytical results. Critical analytical instruments, such as HPLC, commonly use organic solvents. Reagent and collection vessels are often left open or ineffectively closed with films and aluminum foil, venting potentially toxic vapours to the atmosphere. These systems offer a mechanical means to reduce exposure to volatile organic fumes and hazardous waste solvents. They are modular and versatile, with a full range of available options to adapt to most any equipment setup, including a variety of materials for chemical compatibility and multiple port connections and bottle cap sizes.
www.coleparmer.com/
High-resolution imaging
May/June 2018 Laboratory Focus www.laboratoryfocus.ca
Human immune monitoring panel kit Fluidigm has launched the Maxpar Human Immune Monitoring Panel Kit for comprehensive immune cell profiling in cancer and immunemediated diseases. Designed for use with the company’s Helios CyTOF mass cytometry system, the new kit contains 29 metal-labeled antibodies and reagents designed and optimized for deep immune profiling of human peripheral blood mononuclear cells in a single tube. The panel biomarkers were selected in collaboration with pharmaceutical companies and academic institutions, and are optimized for routine high-parameter immune profiling. Multiple third-party data-analysis options are available to analyze results from the panel, including Cytobank and GemStone software. Verity Software House is providing free access to an enhanced version of GemStone software to customers who purchase the kit.
https://www.fluidigm.com/
Compounds mixer The Thinky ARM-310 engineering compounds mixer provides consistent mixing results with simple operation and no mixing implements to clean. Like the rest of the Thinky mixing machines, the Thinky ARM310 uses planetary centrifugal motion to quickly and homogeneously disperse engineering compounds such as adhesives, sealants, lubricants, cosmetics, or pharmaceuticals. Mixing takes place in removable containers so that there is no mess to clean up after mixing to save valuable time and avoiding cross-contamination. The automated mixing process works in seconds to minutes, and provides the same mixing results every time, with a fast return on investment compared to manual mixing. Mixing programs can be stored in the mixer’s memory for easy operator use.
https://www.intertronics.co.uk/ Under development since 2007, patented since 2010, and released to the market in 2017, Fluid Imaging Technologies introduces the newest member of the FlowCam family, the FlowCam Nano. Using oil-immersion flow microscopy, Nano-Flow Imaging delivers high-resolution images of nanoparticles in your liquid samples. FlowCam Nano from Fluid Imaging Technologies automatically reveals protein agglomerates, silicon oil droplets, glass shards and other opaque, transparent and translucent sub-visible particles with the highresolution imagery needed for identification. The instrumentation provides digital images of particles ranging in size from 300 nm to 30 µm. Ideal for analytical scientists, biochemists, formulation scientists, lab managers and other biopharmaceutical professionals. The particle analyzer was developed to find, expose and identify nanoparticles in protein formulations and help track the progression of protein agglomerates from individual, proteinaceous particles into the larger aggregates that pose a threat to the safety, efficacy, stability, and longevity of parenteral bioformulations. In addition, it may serve as a valuable companion to USP<788> compliance testing methods for particulate matter by documenting the presence and type of nanoscale particles, which may cause failed test results.
www.fluidimaging.com
RNAscope assays Bio-Techne launches its RNAscope VS Duplex kit, which delivers simultaneous in situ detection of two RNA species on an automated platform. The assay enables experiments including co-localization studies and gene expression profiling in specific cell types identifiable with known markers. The assay delivers improved specificity and sensitivity with clean signals, allowing researchers to pinpoint gene expression at single-molecule sensitivity. In addition, Bio-Techne launches the RNAScope VS Universal HRP and AP assays, which will integrate with Roche’s mRNA universal software. The assays also have protocols that allow dual staining with immunohistochemistry or immunofluorescence. Bio-Techne also releases the updated RNAscope 2.5 VS Reagent Kit-BROWN and -RED assays, which deliver permanent and intensified staining. The firm claims the assays are suitable for archiving and are ideal when anticipating low copy target gene expression.
https://www.bio-techne.com/
