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NEW PRODUCTS Liquid chromatography & mass spectrometry
Thermo Fisher Scientific Inc. has demonstrated the advanced analytical capabilities delivered by combining its Exactive liquid chromatography/mass spectrometry (LC/MS) system with its Transcend technology for a complete LC/MS solution. For challenging screening applications, including complex samples containing pesticides, metabolites or other target compounds, this configuration combines automated online sample preparation for high throughput with the dual benefits of ultra-high resolution and accurate mass. The Exactive delivers ultra-high resolution and accurate mass data to enable the rigorous and rapid characterization of compounds in complex matrices. The easy-to-use instrument streamlines many technical steps that normally require specialized setup and operation, and provides simultaneous qualitative and quantitative results. In addition, Thermo Scientific’s TurboFlow technology within Transcend offers automated, online sample preparation methodologies to simplify analytical workflows and increase data quality.
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360 µm High Pressure Fittings VICI Valco’s new 360 µm High Pressure Fitting design permits direct connection of 360 micron OD fused silica, PEEK, stainless or electroformed nickel tubing without having to use troublesome liners. Because of the fitting’s compact size and fine two to 56 threads, a leak-free connection that seals at pressures well in excess of 20,000 psi can be easily formed with the available manual tool. The 360 µm fittings are available with a PEEK or stainless nut. The PEEK nut is supplied with a glassfilled PEEK ferrule, while the stainless nut uses a 316 SS ferrule. The ferrule snaps into the nut so that the fitting is ‘one-piece,’ but the ferrule is free to rotate and does not twist the tube as the nut is tightened. A wide range of micron bore sizes is available.
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Water Purification Millipore Corporation has released its ICW-3000 water purification system. The new system produces a constant and reliable source of ultrapure water for Dionex IC (Ion Chromatography) systems. Ultrapure water from the ICW-3000 system can increase the precision of IC analyses. The ICW-3000 system provides a continual flow of ultrapure water to the eluent generator and regenerant lines of the suppressor. This reduces the carbonate content in the water – sharply decreasing contamination risks and improving experiment reproducibility, while also eliminating the need for helium. The water system also eliminates the need for eluent preparation and the instrument downtime that occurs when filling eluent bottles. With only two tubes and one power cord to connect, the new system is designed for plug-and-play installation, as well as everyday use. The user fills the system’s 10 L tank with pure water in order to produce a constant flow of ultrapure water for the IC system. The ICW-3000 system is remotecontrolled by the Dionex IC system: both systems are 100 per cent compatible.
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May 2010 Laboratory Focus www.bioscienceworld.ca
Data Logger The Simple Logger® II Model L481 bipolar 850VDC data logger gives a choice of data storage modes and storage rates. This allows the operator to configure the logger to optimize memory usage to the application at hand. Extended Recording Mode (XRM®) and delayed start time are two of the many application features in this logger. Its internal memory allows storing over 240,000 measurements. User programmable scale and engineering units are available. Battery operation and compact size allows for installation in tight locations without the need for external power. A series of front panel LEDs provides a quick status of the logger’s state and memory usage. The Simple Logger® II Model L481 records DC voltage at user-selectable rates from eight every second to one every day. Voltages can be measured up to +850 VDC with 0.1 V resolution. DataView® software facilitates real-time viewing of measurement data even while recording.
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Sterilisation Cabinet The GLE-UVSC UV sterilisation cabinet provides effective decontamination of reagents and equipment before carrying out sensitive PCR reactions, particularly when amplifying DNA sequences which are either in limited supply or of low copy number. Four timer-controlled 15-Watt UV-C bulbs enable the user to control the exposure time and dose of high energy UV-C irradiation required to denature nucleic acids that cause unwanted background contamination, while a timer override switch allows the UV source to remain on indefinitely if preferred. Safety interlocks switch off the UV-C bulbs automatically when the cabinet side doors are opened, preventing accidental exposure to the UV source. The cabinet is constructed from UV-C-impermeable 10mm acrylic, which also serves as an effective barrier against radioactive isotopes, allowing the user to work in complete safety with high energy ß-emitters such as 32P. A single white light bulb illuminates the work area when the cabinet is in use.
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Cloud Computing Application The new version of Cresset’s FieldStere bioisostere generator delivers shorter lead optimization cycles to computational and medicinal chemists by enabling them to choose the best syntheses, to fine-tune portions of lead molecules and to scaffold hop to expand into new areas of chemical space. FieldStere V2.0 is the first in Cresset’s new generation of ‘cloud enabled’ applications. This brings real-time assessment of new directions for medicinal chemistry, patentability and in-licensing potential of drug candidates a step closer. FieldStere can also be run as a traditional desktop application, allowing users without a large computing infrastructure to benefit from the same functionality. FieldStere V2.0 introduces more flexible licensing and new features to improve productivity. A command line interface supports scripting and workflow systems, while FieldStere databases now have automatic fragment de-duplication and time-stamping to support results tracking in ELN & patent applications. FieldStere also enables results to be exported as PDFs and copied in 2D or 3D for pasting into drawing applications or presentations.
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