This issue is focused on "Life, Positively" — our annual HIV/AIDS awareness and World AIDS Day issue. It includes features on Carolinians who made POZ magazines Top 100, living healthy, looking at the history of the pandemic, including Patient Zero, the ways in which the virus affects the body and a plethora of other timely and useful articles. We also take a look at transgender issues and the Transgender Day of Awareness. We also have current local, regional, national and global news and interesting features along with compelling commentary.