DPR
Health & Wellness M agazine
Issu e # 01 | Su m m er 2019
- DPR HEALTH AND W ELLNESS M AGAZI NE'S M AI DEN I SSUE - GENE EXPRESSI ON ASSESSM ENT & M ANAGEM ENT
- HEALTHY AGI NG W I TH ESSENTI AL OI LS - THE NEW FACE OF STRESS - THE A TO Z'S OF PPAR'S
Con ten ts 3
Message f r om t he Doct or
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Publisher 's Not e
5-7
Gene Expr ession Assessm ent
8 - 12 Healt hy Ageing w/ Essent ial Oils 13 - Sr ess Has Com e A Long Way 14 - 16 PPAR's 18 - Bookm ar ked 21 - 26- Aut ophagy 27 - 31 The Ar t of Sust ainable Living
M essage Fr om th e Doctor
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Dr. Juan Paolo D. Bellosillo, ND International Fellow of Integrative Medicine and Diplomate in Whole Medical Systems, Anti - Aging Medicine, Cardio Metabolic Medicine, Holistic Medicine and Photo Bio Medicine ; Specialized in Integrative Fitness and Nutrition
DPR is an acronym for Doc Pao Republic. It is a community established to promote harmonious living thru Holistic Wellness. Our goal is to save lives, optimize living by protecting your health and lengthen the life expectancy of people for them to enjoy life to the fullest. With DPR Health and Wellness Magazine, we intend to intensify the communication line of DPR to the general public, providing informative stories and write-ups that will heighten health consciousness and social awareness of individuals.
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Our maiden issue is the result of our collaborative efforts between medical practitioners , establishments from the private and government sectors and ReDLark, Manila. We intend to impart all our knowledge to help raise awareness on health and what we can do to improve our environment so that nature itself can thrive and help heal people in the process.
A clear understanding and knowledge on living in balance is very important because it will define our future and our capacity to withstand the demands and trivialities of our daily lives.
With our maiden issue focused on prolonging lives and achieving what the centenarians were able to reach, I hope we all continue to LI VE A LEGACY FOR ONE HUMANI TY. DOC PAO
FROM THEPUBLISHER DPR Health and Wellness Magazine is published by REDLARK,MANILA
Th e Ben efits of Natu r e to Ou r H eal th The idea that spending time in nature can make you feel better is intuitive. We all feel this to be true, and many of us have anecdotes of our own or from friends or family that support the idea. People who have been suffering from stress, sickness, or a trauma can spend quiet contemplative time in gardens or taken to the mountains or woods to heal. But nature is not just wilderness. The benefits of nature can also be found in our communities? parks and green spaces. Researchers are amassing a body of evidence, proving what we all know to be true: nature is good for us and has both long and short term mental and physical health benefits. - REDLARK ONLINE
The idea of using DNA Profiling for our health and wellbeing is a relatively new approach in the Philippines. A common perception of DNA testing is usually limited to crime scene investigations, paternity testing and the beast cancer gene (also known as The Angelina Jolie effect). Fortunately for those looking for more in-depth approach in meeting their health goals, the Philippines have caught on to one of the most significant events in medicine and health-care. This modern day science
is starting to gain traction with local medical health practitioners and diagnostic centers offering different forms of DNA Profiling or genetic testing to interested patients. Gone are the days of one-size-fits-all health-care approach. It has been proven through numerous researches that gene profiling and personalized scientific treatment plans offer better ability to address an individual?s health-care needs.
Gen e Expr ession Assessm en t an d M an agem en t : A NEW GOLD STANDARD IN H EALTH AND W ELL-BEING By Dr. Ryl an Fl or es, Or th opaedic Su r geon & Nu tr igen om ics Pr actition er One of the key players in the country using DNA Profiling for a patient ?s health is called FITGENES, a company based in Australia providing DNA-based, personalized health and wellbeing reports focusing on selected genes that peer-reviewed independent research has indicated may make a difference in supporting better health and lifestyle. The advantage of acquiring a Fitgenes report is that it is delivered through an accredited Practitioner trained to interpret the personalized DNA reports and assist patients in meeting their health goals. Fitgenes? personalized genetic profiling offers insight in to how our body responds to diet, nutrition, exercise and lifestyle. While science is able to map an
individual's entire genome, Fitgenes? genetic profile reports are evidence-based, incorporating published scientific literature on nutrigenomic outcomes. These reports support accredited practitioners in their practice to develop personalized programs to improve a client 's health and wellbeing based on their individual goals. Knowing how to accurately interpret the results and turn them in to actionable, everyday health and wellbeing is where Fitgenes and Accredited practitioners excel. Currently, there are two Fitgenes DNA-based reports that are available through Philippine practitioners: Health & Wellbeing and Carb Choice.
?Health is not everything, but without health, everythingis nothing?, said Arthur Schopenhauer, a German philosopher best known for his work TheWorld as Will and Representation.
itgenes Health & Wellbeing Genetic Profile Report is a comprehensive report where a number of genes involved in staying healthy and which can be up- or down- regulated by lifestyle changes, diet, supplementation and wellness interventions are tested. The report is broken down into six sections addressing key factors that play major roles in an individual?s overall health: Inflammation, Cell Defence, Vitamin D Receptors, Methylation and Homocysteine Metabolism, Cardiovascular Health and Fat & Cholesterol Metabolism. The report is supported with a personalized health and wellbeing program delivered by an accredited practitioner and monitored over a course of a few weeks.
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Carb Choice looks at an individual?s AMY1 gene copy number variation and how to monitor carbohydrates consumption in order to get healthy, prevent Type 2 Diabetes and/or achieve weight and fitness goals. AMY1 is a gene producing salivary amylase plays a major role in the digestion of starchy carbohydrate found in grains, legumes, fruit, vegetables, nuts and seeds. Key benefits include weight management issues, greater energy levels for exercise, manage gut irritations, bloating and bowel problems, glucose management, gluten intolerance management, metabolic syndrome management. The procedure is very easy and pain-free. Under supervision of a Fitgenes accredited practitioner, a buccal swab is collected, sent to the laboratory and the patient just waits for the report which will be interpreted by the practitioner. More information about Fitgenes genetic profile reports can be found on fitgenes.com.
Fi t gen es?gen et i c pr of i l e r epor t s ar e ev i den ce-based, i n cor por at i n g pu bl i sh ed sci en t i f i c l i t er at u r e on n u t r i gen om i c ou t com es.
H ealthy Aging with Essential Oils
Before we find out how essential oils affect our aging body, first we need to know what essential oils are. Essential oils are aromatic, volatile liquids found within shrubs, flowers, trees, roots, bushes, resins, and seeds. Most essential oils are extracted from plant sources using steam distillation and are highly concentrated, making them far more potent than dried botanicals. Essential oils are not new. Records describe the use of aromatic substances as far back as 4500 BC. The Egyptians were masters in using essential oils and other aromatics in the embalming process. Religious books such as the Holy Bible and the Holy Qur ?an mention aromatic plant species and their importance on numerous occasions. There are many natural, unnatural, internal and external causes of aging. Despite many theories and research that point to the cause of aging, the oxidative theory that focuses on the effect of free radicals on the cell is the most widely accepted. With the plentiful data on the stress brought about, by these free radicals on our body, comes significant amounts of research on the effects of antioxidants on health, especially on cell aging. So, what do these fragrant essential oils have to do with aging and oxidation? A biochemist from the University of Cairo in the late 1980?s, named Dr. Radwan Farag was among the first to show in vitro how some essential oils were able to slow the rancidity of fatty oils like cottonseed oil. His studies showed that thyme oil with 55.7 % thymol and 36% p-cymene as well as clove oil with 85.3% eugenol resulted in significant protection against rancidity to the cottonseed oil. Thyme reduced rancidity by 20%, while clove oil reduced rancidity by almost 30%. In the early 1990?s, in vivo studies were done at the Scottish Agricultural College in the United Kingdom and the Semmelweis University of Medicine in Hungary, their clinical trials found that daily lifelong feeding of thyme and clove oils to laboratory animals preserved key antioxidant levels in the liver, kidneys, heart and brain. More importantly, essential oils of thyme (Thymus vulgaris), clove (Syzygium aromaticum), nutmeg (Myristica fragrans) and black pepper (Piper nigrum) halted the oxidation and destruction of long-chain poly unsaturated fatty acids (PUFAs) throughout the animal. Studies done on clove oil in LKT Laboratories in Minnesota, USA found that five sesquiterpene compounds within clove oil significantly increase levels of glutathione- S-transferase (GST), one of the most important detoxifying enzymes in our bodies that is crucial for neutralizing potential cancer causing chemical compounds. A similar study was done by Yokota, et al. in 1986 up to 2013 that showed a diet with 5% eugenol, the main constituent in clove oil, helped protect test animals against the mutagenic and cancer-causing effects of the chemical benzo-a-pyrene in that it increased xenobiotic-metabolizing enzymes that are known to protect against cancer.
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Frankincense Healthy Aging with Essential Oils
by Dr. Lady Tagulao, Integrative Medicine and Natural Medicine ; Essential Oils Specialist
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rankincense, also known as ?oleo-gum resin or olibanum?, is considered the ?holy anointing oil? in the Middle East and had been used in religious ceremonies for thousands of years. Frankincense was valued more than gold during ancient times and mentioned in one of the oldest known medical records, Ebers papyrus, an ancient Egyptian list of 877 prescriptions and recipes. There are over 42 species of frankincense but only a few with therapeutic importance. Four of the most well-known species are: Boswellia carterii from East Africa (Somalia and Yemen), Boswellia sacra from Oman, Boswellia frereana from Somalia and Boswellia serrata from India. Therapeutic-grade frankincense oil contains compounds such as boswellic acids and incensole acetate, giving frankincense its physical and emotional therapeutic properties. Boswellia carterii is the most studied frankincense species. A significant 2009 study titled, ?Frankincense oil derived from Boswellia carterii induces tumor specific cytotoxicity?. With such groundbreaking study of an essential oil, sourcing and quality is utmost importance. Other studies done on Boswellia carterii resin extracts exhibited not only anti-inflammatory properties but immunomodulary activity. Boswellia sacra, called Sacred Frankincense is the source of premium
frankincense resin. The only frankincense specie native to Oman that used to be only available to royalty. Omani frankincense is regarded as the rarest, most sought-after aromatic in existence. Studies have shown cytotoxic activity towards basal cell carcinoma, pancreatic and breast cancer cells in vitro. A 2010 study done by Calzavara-Pinton P, et al., on the topical effects of boswellic acids for the treatment of photo aged skin showed significant improvement of the Dover ?s global score for photoaging, tactile roughness, and fine lines, as well as, with non-invasive diagnostic techniques, an increase of elasticity and a decrease in sebum excretion. Along with high antioxidant and DNA-protecting essential oils, having a diet rich in vitamins, minerals, enzymes and antioxidants can dramatically increase glutathione levels and reverse the signs of aging. Consuming high ORAC (oxygen radical absorbance capacity) foods consistently, can combat free radical damage in the body associated with premature aging and degenerative diseases. An example is a special variety of wolfberry grown on the Yellow river in the Ningxia province. to have the highest ORAC score of any food.
The Ningxia cultivar wolfberries, among 17 types of wolfberries, has by far the highest levels of immune boosting polysaccharides. It also has 33 times the antioxidant power of oranges and 120 times antioxidant potential of carrots. In a perfect environment, the human life span has the potential to reach up to 120 years. Unfortunately, with today?s diet and lifestyle, it can
be a challenge. Certain longevity hotspots around the world have similar attributes that we can emulate? having a nutritionally dense diet, limited caloric intake to regular fasting, belonging to a close-knit community and continuous daily physical activity to keep the body active and strong for longer.
STRESS HAS COME A LOOONG WAY! Stress is a feeling of emotional or physical tension. It can come from any event or thought that makes you feel frustrated, angry, or nervous. Stress is your body's reaction to a challenge or demand. In short bursts, stress can be positive, such as when it helps you avoid danger or meet a deadline. But when stress lasts for a long time, it may harm your health. Some 40 years ago the word STRESS was hardly used. People were afraid, anxious, fearful...but not stressed. Nowadays almost everyone in this civilized world is stressed. Even little children are subjected to the stress of vying for a slot in good preschools! In the US dog owners shell out 200 dollars a month to get their dogs' supply of Prozac. Yes even animals are stressed! The sale of tranquilizers and sedatives have shot up.
"Som e 40 year s ago the w or d STRESS w as har dly used. People w er e afr aid, anxious, fear ful...but not str essed. Now adays alm ost ever yone in this civilized w or ld is str essed. Even little childr en ar e subjected to the str ess of vying for a slot in good pr eschools! In the US dog ow ner s shell out 200 dollar s a m onth to get their dogs' supply of Pr ozac. Yes even anim als ar e str essed!"
Of course, humans, intelligent as they are have tried all possible means to combat stress...most of them you read on the net and social media. Some methods like oxygen bars, stress balls, shake up dolls and stuffed toys (that one shakes till all their fur or hair stand up on end. In lieu of yours) ...and yes, drugs...and heaven knows what else are very marketable ....all because of stress. Mainstream medicine has finally recognized the role of stress in various ailments. For example : this growing epidemic explains why we have so many diabetics as well people with elevated cholesterol levels, hypertension, migraines, suicidal tendencies ...among other things. Yes indeed...STRESS HAS COME A VERY LONG WAY!
by Dr . Ophelia Nubla , Str ess M a na gement a nd Cr a nio Sa cr a l Ther a py ; Holistic M edicine & Pediatr ics
PPARs Per ox i som e Pr ol i f er at or Act i vat ed Recept or s
PPARs Peroxisome Proliferator Activated Receptors are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism(carbohydrate, lipid, protein), and tumorigenesis of higher organisms. PPARsgene activators in the form of Peroxisome Proliferator Activated Receptor Agonists (Unique combination of Long Chain Polyunsaturatted Fatty Acids) will direct the exact amount of nutrients needed by your body, unifying biological systems, functions and processes. Your immune system will then perform optimally at all times! PPARs series is also coupled with RICH CELLULAR nutrition in the form of nucleic acids that support the cells activated by your genes.
The rich SUPERFOOD mircro-algae component provides the raw natural nutrition needed to FUEL your body for HEALING and OPTIMAL HEALTH. Nat ural Gene Act ivat or s and Gene Regulat or s Uniquely rich in PPARs Agonist (Gene Activator), CGF, nuclei acids, Long-chain fatty acids, antioxidants and phytonutrients. SimplyNature?s PPARs series is abundant in both Gene Activators and the supporting nutrients needed for healthy gene/cellular activity. 100% Nat ural Clean ?Whole Food? SimplyNature PPARs Series is not a Synthetic Vitamin, Pharmaceutical drug or medicinal herb. It is a 100% natural plant-based whole-food; free from additives, binders, fillers, or artificial substances. 100% Nat ural ?Gr een Super f ood? Plant-based natural ?nutritional giants?, the Micro-Algae component of
SimplyNature?s PPARs series is a SUPERFOOD packing more vitamins, minerals, essential amino acids, proteins, essential fatty acids and phytonutrients combination per gram than any other food source. 95% Bio-available Nut r ient s and 60% Plant Pr ot ein SimplyNature PPARs is plant-based with high digestibility, our nutrients are 95% Bio-available which means they are quickly absorbed and are more completely used by your body. Our micro-algae is also the richest source of plant protein, having an incredible 60% protein content. Fight s and Pr event s Disease SimplyNature PPARs series is not only a whole-food, it is a ?Healing Food?. It specifically triggers your body?s immune and repair system to fight and protect you from diseases such as Cancer, Cardiovascular, Metabolic Syndromes, and even mental acuity.
3 isoforms of PPARs ? (alpha) expressed in liver, kidney, heart, muscle, adipose tissue, and others. ?/? (beta/delta) expressed in many tissues but markedly in brain, adipose tissue, and skin. ? (gamma) expressed in virtually all tissues, including heart, muscle, colon, kidney, pancreas, and spleen.
Cr yptom onadales and PPARS Appointed Distr ibutor for Asia Pacific (Singapor e, Philippines, H ong Kong, M acau)
Unit 711, 7th Floor, National Life Insurance Building, 6762 Ayala Ave., Makati City, 1226 Phils. Email: wecare@simplynature.asia Tel: +632 833 5047
h ttps://www.simplynature.asia/https://www.simplynature.asia/
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Figure 1: Our cells have different specialized compartments. Lysosomes constitute one such compartment and contain enzymes for digestion of cellular contents. A new type of vesicle called autophagosome was observed within the cell. As the autophagosome forms, it engulfs cellular contents, such as damaged proteins and organelles. Finally, it fuses with the lysosome, where the contents are degraded into smaller constituents. This process provides the cell with nutrients and building blocks for renewal. 2016 Nobel Laureate discovered and elucidated mechanisms underlying autophagy, a fundamental process for degrading and recycling cellular components.
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The word autophagy originates from the Greek words auto-, meaning ?self ?, and phagein, meaning ?to eat ?. Thus,autophagy denotes ?self eating?. This concept emerged during the 1960?s, when researchers first observed that the cell could destroy its own contents by enclosing it in membranes, forming sack-like vesicles that were transported to a recycling compartment, called the lysosome, for degradation. Difficulties in studying the phenomenon meant that little was known until, in a series of brilliant experiments in the early 1990?s, Yoshinori Ohsumi used baker ?s yeast to identify genes essential for autophagy. He then went on to elucidate the underlying mechanisms for autophagy in yeast and showed that similar sophisticated machinery is used in our cells. Ohsumi?s discoveries led to a new paradigm in our understanding of how the cell recycles its content. His discoveries opened the path to understanding the fundamental importance of autophagy in many physiological processes, such as in the adaptation to starvation or response to infection. Mutations in autophagy genes can cause disease, and the autophagic process is involved in several conditions including cancer and neurological disease. Yoshinor i Ohsum i was bor n 1945 in Fukuoka, Japan. He r eceived a Ph.D. f r om Univer sit y of Tokyo in 1974. Af t er spending t hr ee year s at Rockef eller Univer sit y, New Yor k, USA, he r et ur ned t o t he Univer sit y of Tokyo wher e he est ablished his r esear ch gr oup in 1988. He is since 2009 a pr of essor at t he Tokyo I nst it ut e of Technology.
TheMany Facets of
Autophagy
Degradation ? a central function in all living cells In the mid 1950?s scientists observed a new specialized cellular compartment, called an organelle,containing enzymes that digest proteins, carbohydrates and lipids. This specialized compartment is referred to as a Lorem ipsum dolor sit amet,ofconsetetur ?lysosome? and functions as a workstation for degradation cellular constituents. The Belgian scientist sadipscing elitr, sed diam Christian de Duve was awarded the Nobel Prize in Physiology or Medicine in 1974 for the discovery of the lysosome. New observations during the 1960?s showed that large amounts of cellular content, and even whole organelles, could sometimes be found inside lysosomes. The cell therefore appeared to have a strategy for delivering large cargo to the lysosome. Further biochemical and microscopic analysis revealed a new type of vesicle transporting cellular cargo to the lysosome for degradation (Figure 1). Christian de Duve, the scientist behind the discovery of the lysosome, coined the term autophagy, ?self-eating?, to describe this process. The new vesicles were named autophagosomes.
A groundbreaking experiment Yoshinori Ohsumi had been active in various research areas, but upon starting his own lab in 1988, he focused his efforts on protein degradation in the vacuole, an organelle that corresponds to the lysosome in human cells. Yeast cells are relatively easy to study and consequently they are often used as a model for human cells. They are particularly useful for the identification of genes that are important in complex cellular pathways. But Ohsumi faced a major challenge; yeast cells are small and their inner structures are not easily distinguished under the microscope and thus he was uncertain whether autophagy even existed in this organism. Ohsumi reasoned that if he could disrupt the degradation process in the vacuole while the process of autophagy was active, then autophagosomes should accumulate within the vacuole and become visible under the microscope. He therefore cultured mutated yeast lacking vacuolar degradation enzymes and simultaneously stimulated autophagy by starving the cells. The results were striking! Within hours, the vacuoles were filled with small vesicles that had not been degraded (Figure 2). The vesicles were autophagosomes and Ohsumi?s experiment proved that authophagy exists in yeast cells. But even more importantly, he now had a method to identify and characterize key genes involved in this process. This was a major break-through and Ohsumi published the results in 1992.
Autophagy genes are discovered Ohsumi now took advantage of his engineered yeast strains in which autophagosomes accumulated during starvation. This accumulation should not occur if genes important for autophagy were inactivated. Ohsumi exposed the yeast cells to a chemical that randomly introduced mutations in many genes, and then he induced autophagy. His strategy worked! Within a year of his discovery of autophagy in yeast, Ohsumi had identified the first genes essential for autophagy. In his subsequent series of elegant studies, the proteins encoded by these genes were functionally characterized. The results showed that autophagy is controlled by a cascade of proteins and protein complexes, each regulating a distinct stage of autophagosome initiation and formation.
The Nobel Assembly, consisting of 50 professors at Karolinska Institutet, awards the Nobel Prize in Physiology or Medicine. Its Nobel Committee evaluates the nominations. Since 1901 the Nobel Prize has been awarded to scientists who have made the most important discoveries for the benefit of mankind.
During the 1970?s and 1980?s researchers focused on elucidating another system used to degrade proteins, namely the ?proteasome?. Within this research field Aaron Ciechanover, Avram Hershko and Irwin Rose were awarded the 2004 Nobel Prize in Chemistry for ?the discovery of ubiquitin-mediated protein degradation?. The proteasome efficiently degrades proteins one-by-one, but this mechanism did not explain how the cell got rid of larger protein complexes and worn-out organelles. Could the process of autophagy be the answer and, if so, what were the mechanisms?
Au t oph agy ? an essen t ial m ech an ism in ou r cells After the identification of the machinery for autophagy in yeast, a key question remained. Was there a corresponding mechanism to control this process in other organisms? Soon it became clear that virtually identical mechanisms operate in our own cells. The research tools required to investigate the importance of autophagy in humans were now available. Thanks to Ohsumi and others following in his footsteps, we now know that autophagy controls important physiological functions where cellular components need to be degraded and recycled. Autophagy can rapidly provide fuel for energy and building blocks for renewal of cellular components, and is therefore essential for the cellular response to starvation and other types of stress. After infection, autophagy can eliminate invading intracellular bacteria and viruses. Autophagy contributes to embryo development and cell differentiation. Cells also use autophagy to eliminate damaged proteins and organelles, a quality control mechanism that is critical for counteracting the negative consequences of aging. Disrupted autophagy has been linked to Parkinson?s disease, type 2 diabetes and other disorders that appear in the elderly. Mutations in autophagy genes can cause genetic disease. Disturbances in the autophagic machinery have also been linked to cancer. Intense research is now ongoing to develop drugs that can target autophagy in various diseases. Autophagy has been known for over 50 years but its fundamental importance in physiology and medicine was only recognized after Yoshinori Ohsumi?s paradigm-shifting research in the 1990?s. For his discoveries, he is awarded this year ?s Nobel Prize in physiology or medicine.
MLA style: Press release. NobelPrize.org. Nobel Media AB 2019. Mon. 13 May 2019. <https://www.nobelprize.org/prizes/medicine/2016/press-release/>
Ti t l e Goes H er e Issu e # 00 | Su m m er 2016
Mithun with BNIM ? Sustainability Treehouse, West Virginia. Image via huffingtonpost.com
THEARTOFSUSTAINABLELIVING
Designed by architect Eleena Jamil of Malaysia as the winning entry in the Millennium Schools competition organized by Illac Diaz's MyShelter Foundation, the structure was recently completed in Camarines Sur, and is proud to call itself the first full bamboo school in the Philippines.
Frank Lloyd Wright first used the term ? organic architecture?in an article for Architectural Record in August 1914. He wrote that ?the ideal of an organic architecture? is a sentient, rational building that would owe its ?style?to the integrity with which it was individually fashioned to serve its particular purpose? a ?thinking?as well as ?feeling?process.?1 In this article and many more up to his death, Wright continued to try, not always with much success, to explain what organic architecture was and was not to him. His buildings spoke far more succinctly than his writings. He wanted organic architecture to be more than his own work, more than his own ?style?. He wanted to generate a philosophy of building that could inspire and guide architects and laymen long into the future. While it is not easy to define organic architecture, there are principles at work in Frank Lloyd Wright?s buildings that transcend his personal expression. It is important to note that Wright was not the first architect to use the term organic architecture, nor was he the last. The concept of an organic style meant different things to different architects and manifested itself in a variety of ways.
Building and Site The two have a very special relationship in organic architecture. The site should be enhanced by the building, and the building derives its form partially from the nature of the site. Sometimes this is done by similarity (prairie house and prairie landscape), sometimes by contrast (Fallingwater and a forest glen). In natural settings, the buildings may open out (Usonian houses), and in urban settings, turn inward (the Larkin and Johnson Wax Buildings). The building grows out of the landscape as naturally as any plant; its relationship to the site is so unique that it would be out of place elsewhere.
Materials These are used simply in a way that enhances their innate character and optimizes their individual color, texture, and strength. One material is not disguised as another. The way a building comes together, how one material joins another; the very form of the building should be an expression of the nature of the materials used. In organic architecture, only a few materials are used, both inside and outside.
Shelter A building should convey a sense of shelter, refuge, or protection against the elements. Its inhabitants should never lack privacy or feel exposed and unprotected. Space ?The reality of the building does not consist of the roof and the walls but the space within to be lived in?, said Wright. The interior space determines exterior form (as in Unity Temple). Interior space is not packed in boxes called rooms; rather, space should flow freely from interior area to interior area. Rooms are never simple rectangles but are broken up vertically and horizontally (alcoves, L-shapes, lowered ceilings, and decks) to give the eye and mind something delightful and sometimes something mysterious to enjoy. An area is never fully comprehended when viewed from one point but must be slowly experienced as one moves through the space. One space can introduce another, heightening the effect, or function as part of a series, such as the playroom hallway and the playroom in the home. Proportion and Scale The human body should be the measure of a building and its furnishings. Wright spoke of the ?integral harmony of proportion to the human figure? to have all details so designed as to make the human relationship to architecture not only convenient but charming.? Nature Nature is an architect?s school. The creative possibilities of form, color, pattern, texture, proportion, rhythm, and growth are all demonstrated in nature. Organic architecture does not imitate nature but is concerned with natural materials, the site, and the people who will occupy the buildings. Repose Quiet, serene, tranquil space is a fitting environment for human growth. It is achieved by simple architectural masses that reflect the uncluttered spaces within and that are carefully related to the site. Grammar Each building has its own grammar, its distinct vocabulary of pattern and form. All parts of the building from the smallest detail to the overall form thus speak the same language. The grammar may be completely different for two buildings, although both are organically designed (the Johnson Wax Building versus Taliesin West). Ornament Not all organic architecture has ornament, but when used, it is developed as an integral part of the material, not applied. Examples are patterns cast in concrete or carved in stone, leaded glass panels, and tile or glass mosaics.
Human Values ?All values are human values or else not valuable?, said Wright. ?Human use and comfort should have intimate possession of every interior? should be felt in every exterior.? Simplicity Organic architecture is simple because its scheme and design are clear. ?The highest form of simplicity is not simple in the sense that the infant intelligence is simple? nor, for that matter, the side of a barn. Simplicity in art is a synthetic positive quality in which we may see evidence of mind, breadth of scheme, wealth of detail and withal a sense of completeness found in a tree or flower.? Mechanical Systems and Furnishings These are an integral part of the building: they are not added on, stuck in or unduly exposed. Sculpture and painting have to become elements of the total design. Furniture should be built-in as much as possible. Although these are not all of the principles of Wright?s organic architecture, they outline his general philosophy. Organic design aims to include them, but not even Frank Lloyd Wright achieved them totally in each of his buildings. As Wright himself wrote, ?The complete goal of the ideal of organic architecture is never reached. Nor need be. What worthwhile ideal is ever reached??
http://www.flwright.org/ckfinder/userfiles/files/Wright-Organic-Architecture.pdf
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