Harmonium pharma

Harmonium Pharma New products features

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

June 2014

Confidential – June 2014

1

Class of 2014 products A.

Understanding diabetes

B.

Complications of diabetes

C.

Harmonium response

D.

MultiBetix

E.

NeuBetix

F.

NeuBetix, Roll-on

G.

ViuBetix

H.

DolBetix

I.

NutriBetix

Confidential – June 2014

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

2

What is diabetes?

Diabetes is a group of metabolic diseases in which a person has high blood sugar. This high blood sugar produces the symptoms of frequent urination, increased thirst, and increased hunger.

Untreated, diabetes can cause many complications:

• Acute complications include diabetic ketoacidosis • Serious long-term complications include heart disease, nerve damages, kidney failure, and damage to the eyes

Diabetes is due to either the pancreas not producing enough insulin, or because cells of the body do not respond properly to the insulin that is produced. There are three main types of diabetes mellitus: • TYPE 1 results from the body's failure to produce insulin • TYPE 2 results from insulin resistance, a condition in which cells fail to use insulin properly, sometimes also with an absolute insulin deficiency • GESTATIONAL DIABETES occurs when pregnant women without a previous diagnosis of diabetes develop a high blood glucose level

Prevention and treatment often involve a healthy diet, physical exercise, not using tobacco, not drinking alcohol and having a normal body weight. Blood pressure control and proper foot care are also important for people with the disease.

Type 1 diabetes must be managed with insulin injections. Type 2 diabetes may be treated with medications with or without insulin.

• Insulin and some oral medications can cause low blood sugar, which can lead to dangerous situations Confidential – June 2014

3

Diabetes worlwide burden Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

Confidential – June 2014

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Risk, prevention and treatment •

Diabetes is now a major global public health problem. The prevalence of diabetes is noted to vary with ethnicity. However, the developing and newly industrialized nations, and the disadvantaged community groups in the developed countries are said to be at highest risk of having diabetes. It has also been demonstrated that, as age increases, the risk of having diabetes and hence the prevalence of diabetes increases.

•

There are several approaches employed to reduce risk for diabetes. To reach the greatest success in reducing the incidence and prevalence of diabetes, both a high risk and a population-based approach should be employed. Pharmacologic therapy or lifestyle modification programs can be used to prevent the risk for development of type 2 diabetes.

•

However, lifestyle modification should be considered first-line therapy. Life style modifications are aimed at losing weight. By getting more exercise and establishing and maintaining healthy lifestyle behaviors (e.g. diet and physical activity), a healthy body weight can be achieved and maintained.

TIMELY ACTION IN THE PREVENTION AND TREATMENT OF COMPLICATIONS OF DIABETES IMPROVES THE PROGNOSIS OF THE DISEASE AND THE QUALITY OF LIFE OF PATIENTS AND THEIR FAMILIES Confidential – June 2014

5

Class of 2014 products

A.

Understanding diabetes

B.

Complications of diabetes

C.

Harmonium response

D.

MultiBetix

E.

NeuBetix

F.

ViuBetix

G.

DolBetix

H.

NutriBetix

Confidential – June 2014

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

6

Complications of diabetes 3 general categories 1. Nerve damage (neuropathy)

Diabetic neuropathy is a nerve disorder that leads to numbness and sometimes pain and weakness generates in the hands, arms, feet and legs. Neuropathy can also cause problems in the digestive system , the heart and sexual organs .

About 50 % of people with diabetes have some degree of nerve damage, but not all experience the same physical symptoms.

Neuropathy is more common in people who have had diabetes for at least 25, who are overweight , do not maintain the level of glucose properly, and have high blood pressure .

The most common neuropathy is peripheral (causes numbness in the feet), and this in turn increases the likelihood of injury , which if not treated properly, can lead to amputation.

2. Damage to large blood vessels (macrovascular

disease)

Excess glucose in the blood causes hardening of the arteries atherosclerosis , which can cause heart attacks, strokes and / or poor circulation in the feet.

Heart disease is the leading cause of diabetes-related death.

Adults with diabetes are 2 to 4 times greater risk of developing these diseases than adults without diabetes.

3. Damage to the small blood vessels such as

capillaries (microvascular disease)

Excess glucose in the blood also thickens capillary walls, thickens blood and can cause small blood vessels have a small leak. Together, these effects reduce blood circulation to the skin, arms, legs and feet. The reduction in capillary blood flow can cause some dark spots on the legs.

Confidential – June 2014

7

Relationship between oxidative stress, hyperglycemia and diabetes complications Oxidative stress plays a pivotal role in the development of diabetes complications, both microvascular and cardiovascular. The metabolic abnormalities of diabetes cause mitochondrial superoxide overproduction in endothelial cells of both large and small vessels, as well as in the myocardium.

This increased superoxide production causes the activation of 5 major pathways involved in the pathogenesis of complications: polyol pathway flux, increased formation of AGEs (advanced glycation end products), increased expression of the receptor for AGEs and its activating ligands, activation of protein kinase C isoforms, and overactivity of the hexosamine pathway.

It also directly inactivates 2 critical antiatherosclerotic enzymes, endothelial nitric oxide synthase and prostacyclin synthase. Through these pathways, increased intracellular reactive oxygen species (ROS) cause defective angiogenesis in response to ischemia, activate a number of proinflammatory pathways, and cause long-lasting epigenetic changes that drive persistent expression of proinflammatory genes after glycemia is normalized (“hyperglycemic memory”).

Atherosclerosis and cardiomyopathy in type 2 diabetes are caused in part by pathway-selective insulin resistance, which increases mitochondrial ROS production from free fatty acids and by inactivation of antiatherosclerosis enzymes by ROS. Overexpression of superoxide dismutase in transgenic diabetic mice prevents diabetic retinopathy, nephropathy and cardiomyopathy.

Confidential – June 2014

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Focus on complications costs Assessing the impact of complications on the costs of Type II diabetes R. Williams, L. Van Gaal, C. Lucioni Diabetologia (2002)

Prevalence

Impact on average cost

Impact on hospitalization cost

Avg. Direct medical cost

No complications

28%

-

-

1505€

Only microvascular complication

19%

1,7

2,1

2563€

Only macrovascular complication

9,6%

2

3,1

3148€

Micro and macrovascular complications

24%

3,5

5,5

5226€

This prevalence-based, bottom-up study, involved over 7000 patients in eight European countries (Belgium, France, Germany, Italy, the Netherlands, Spain, Sweden and the UK)

Neuropathy was not included

Confidential – June 2014

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Diabetes: numerous medical needs Diabetes Type 2 PRE-DIABETES

Diabetes Type 1 & 2

TREATED DIABETIC ORAL ANTIDIABETICS

DIABETIC ON INSULIN TREATMENT

diabetes education glycemic control insulin resistance overweight metabolic syndrome cardiovascular risk Micro and macro vascular complications neuropathies retinopathy nephropathy impotence skin problems diabetic foot complications of insulin progressive deterioration of the quality of life

Confidential – June 2014

10

Class of 2014 products

A.

Understanding diabetes

B.

Complications of diabetes

C.

Harmonium response

D.

MultiBetix

E.

NeuBetix

F.

NeuBetix, Roll-On

G.

ViuBetix

H.

DolBetix

I.

NutriBetix

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com Confidential – June 2014

11

Diabetes: a promising market Today, pharmaceutical companies are mainly focusing on insulin therapy, glycemic control & high-tech devices

1- Numerous complications 2- Strong impact on daily lifestyle

= STRONG UNMET MEDICAL NEEDS

Enormous business oportunity

Confidential – June 2014

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Diabetes: offer analysis Market potential

Unmet need

PRE-­‐‑DIABETES (impaired fasting glucose) TREATMENT OF INSULIN RESISTANCE OVERWEIGHT - OBESITY

High

HYPERTENSION ALTERIA

Medium Low

HYPOGLYCEMIC ORAL CARDIO---­‐‑VASCULAR RISK METABOLIC SYNDROME

COMBINED RISK REDUCTION INSULINS (biosimilar) BLOOD GLUCOSE METERS NEW INSULIN INJECTIONS NO DIABETIC PRODUCTS NUTRACEUTICALS SPECIAL DIETARY PRODUCTS FOR DIABETICS ACCESSORIES FOR DIABETICS DIABETIC SUPPORT SERVICES AND THEIR FAMILIES SKIN CARE DIABETIC PRODUCTS FOR DIABETIC FOOT CARE HYPOGLYCEMIA TREATMENT JAB COMPLICATIONS OF INSULIN DIABETIC NEUROPATHY INSULIN PUMP DIABETIC RETINOPATHY

Confidential – June 2014

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Harmonium: rooted in diabetes Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

•Focus •Innovation •Personalized care

Confidential – June 2014

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Our Focus: overview While patients tend to be careful about their HC spending because the most important products are free of charge, the current traditional support they get through medical care does not fit their need

Unmet needs

N°1

Needs already covered and not a priority for large companies

N°2

Needs already covered by large companies where we can explore entry but only with strong innovative offer N°3 Confidential – June 2014

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Our focus: unmet needs N°1 • • • • • • •

pre-diabetes treatment of insulin resistance diabesity metabolic syndrome combined risk reduction diabetic support services insulin jab complications • lipodystrophy • hypoglycemia • new oral hypoglycaemic drugs • new insulin injection systems

Confidential – June 2014

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

16

Our focus: needs already covered and not a priority for large companies

N°2 • • • • •

skin care foot care additional accessories/products special dietary product neutraceutical products

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

Confidential – June 2014

17

Our focus: needs already covered where we can explore with strong innovation

N°3 • • • •

blood glucose meter insulin pump neuropathy retinopathy

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

Confidential – June 2014

18

Our portfolio is designed to respond to patients needs A COMPLETE RANGE OF INNOVATIVE SOLUTIONS FOR A MORE COMFORTABLE AND SUSTAINABLE DAILY MANAGEMENT OF DIABETES

TREATMENT WITH INSULIN

DARIO, medical device FEELFINE/FINEBETIX, medical device INSULCHECK, technological device

monitor and manage glycemia insulin injections memory

TREATMENT EFFECTS GLUCOSPRINT, glycemia COLIPEX, skin damage, lipodystrophy DOLBETIX, fingers

glycemia booster skin reparation / prevent injections’ complications skin restauration / prevent complications

PREVENTION OF COMPLICATIONS ALLPRESAN, footcare ALLPRESAN PROTECT, footcare NEUBETIX & NEUBETIX ROLL-ON, sensitivity / cutaneous discomfort ATTIVA PLUS, skin alterations MULTIBETIX, vitamines VIUBETIX, vision function

moisturizing action antifungal action smoothing and relieving accelerate riepetelisation process general balance preventive

Confidential – June 2014

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Current products overview Allpresan®

Glucosprint® Defeat hypoglycemia in one drink

Optimal treatment for the diabetic foot

Food supplement

Medical Device Dermocosmetic

Finebetix® needles

Attiva® Plus

Feel the soft injection

The ALL NATURAL solution to skin alterations Medical Device

InsulCHECK®

Medical Device

Helps your pen remember when Technological Device

Colipex® Regenerating treatment for lipodystrophy

Dario® Put Dario in your pocket and let him take over!

Dermocosmetic

Glucose meter & App

Confidential – June 2014

20

Class of 2014 products A.

Understanding diabetes

B.

Complications of diabetes

C.

Harmonium response

D.

MultiBetix, food supplement

E.

NeuBetix

F.

NeuBetix, Roll-On

G.

ViuBetix

H.

DolBetix

I.

NutriBetix

Confidential – June 2014

21

Lifestyle, diabetes and nutrition Nutrition is considered one of the cornerstones in the prevention and treatment of diabetes to prevent or delay the onset of complications.

The keys to control blood glucose levels go from to balance the proportion of carbohydrates (45-60% %), protein (15-20%) and lipids (30 %) to exercise regularly in order to maintain a healthy weight.

Also it is necessary to provide enough essential micronutrients such as vitamins and minerals to ensure the proper functioning of the organs and systems in their vital functions, especially in patients at risk.

The current lifestyle, stress, imbalances in our diet and noncompliance in the hypoglycemic treatment result in the fact that the nutritional needs are not always covered and it is recommended taking a suitable food supplement.

Confidential – June 2014

22

Why do diabetics need a specific nutrition?

People with diabetes have specific nutritional needs which may not be completely fullfilled from the average multivitamin supplement or from their diet alone.

Nutrition is an integral part of the monitoring and care of diabetes. Compliance with a nutritional plan is, however, one of the most difficult goals to achieve due to the changes in lifestyle that it implies.

In order to integrate nutrition effectively into the follow-up and control of diabetic patients, it is necessary to have a multidisciplinary team of professionals basically including a doctor specialized in Endocrinology and Nutrition, a dietician and a trainer in diabetes issues. These team members have to apply an individualized approach for each patient and provide nutritional education to enable the patients to be selfsufficient.

Test results (blood-glucose levels, HbA1c, lipids, blood pressure and quality of life) must be regularly assessed and, if the desired goals are not achieved, the necessary changes must be indicated for future monitoring and overall management of the condition.

Preventive care including nutrition is essential for the patient and cost effective for the health system

Confidential – June 2014

23

Objectives of a balanced nutrition for diabetic people Contribute to normalize glycemia levels

Mitigate the cardiovascular risk (lipids and arterial tension) Provide adequate calories and nutrients to maintain or get closer to the ideal weight Allow normal growth and development in children and adolescents

Meet the needs of pregnancy and lactation when required

Prevention and treatment of acute and chronic complications of diabetes Prevent damage caused by oxidative stress, due to hyperglycemia

Confidential – June 2014

24

Why MultiBetix?

MARKET NEED Diabetics have special nutritional needs. There is a direct relationship between a balanced diet and reducing the complications of diabetes. However it is very difficult for patients to get a balanced diet that would supply the nutrients they need to protect against damage and complications.

WHAT IS MULTIBETIX? It is a complete nutritional supplement that gives people with diabetes the nutrients they need to contribute to a balanced diet. Unlike other supplements, MultiBetix contains in its formula nutrients that do not have a negative effect on diabetes.

It contains 22 nutrients (vitamins, minerals and antioxidants), including Alpha Lipoic Acid, Lutein and DHA in order to facilitate the following physiological functions: • GLUCOSE METABOLISM

• ANTIOXIDATIVE FUNCTION • VISUAL FUNCTION • NERVOUS SYSTEM FUNCTION • CARDIOVASCULAR SYSTEM • IMMUNE SYSTEM • SKIN MAINTENANCE

Confidential – June 2014

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MultiBetix qualitative composition Docosahexaenoic acid (DHA) Alpha-lipoic acid Lutein Folic acid Vit A, B1, B2, B3, B5, B6, B7/B8, B12, C, D and E Calcium Chromium Magnesium Selenium Zinc Manganese Iodine No iron, copper and vitamin K as when consumed in excess may aggravate the complications of diabetes

Confidential – June 2014

26

Multibetix, shaped for diabetics!

Docosahexaenoic acid (DHA) • • • •

Contributes to the normal functioning of heart Plays a role in circulatory disease by decreasing the thickness of the blood and lowering blood levels of triglycerides Has a preventive effect on diabetic neuropathy Plays a key role in the development of eye tissues

Alpha-lipoic acid (ALA) – claims not authorized by EC regulation • • •

Increases insulin sensitivity and help reduce blood sugar and lipids Helps reduce the symptoms of peripheral neuropathy Provides relief from the pain, burning, tingling and numbing caused by diabetic neuropathy

Lutein – claims not authorized by EC regulation • • • •

Reduces the level of oxidative stress markers in diabetes Prevents changes in the retina and hippocampus in diabetes Inhibits the development of cataracts in diabetes Perspectives: is a candidate for preventing infections in diabetes

Confidential – June 2014

27

MultiBetix claims related to diabetes 1. LEVELS OF GLUCOSE AND ENERGY METABOLISM • Chromium helps maintain normal levels of blood glucose • Biotin, calcium, magnesium, manganese, iodin , vitamins B , B2, B, B5, B6,B12 and C contribute to the normal energy metabolism • Zinc contributes to normal metabolism of carbohydrates.

• Vitamin B6 contributes to the normal metabolism of protein and glycogen 2 . NERVOUS SYSTEM • Biotin , magnesium , iodine , vitamins B1 , B2, B3 , B6, B12 and C contribute to the normal functioning of the nervous system • Calcium contributes to normal neurotransmission.

• Alpha-lipoic acid is an antioxidant involved in energy metabolism and helps to limit nerve damage (pain sensations, numbness, tingling and stinging) 3 . VISION • Vitamins A, B2 , B3, and zinc contribute to maintaining normal vision • Lutein is a natural constituent of the retina and has antioxidant effects 4 . ANTIOXIDANT FUNCTION • Vitamins B2, C , E, selenium, zinc and manganese contributes to the protection of cells against oxidative damage

5. CARDIOVASCULAR SYSTEM • Vitamin C contributes to the normal formation of collagen for normal function of blood vessels • Vitamin B1 contributes to the normal functioning of the heart • Calcium contributes to normal blood clotting 6 . TIREDNESS, FATIGUE AND MENTAL FUNCTION • The folate, magnesium, vitamins B2, B3, B5, B6, B12 and C help reduce tiredness and fatigue • The biotin, folate, magnesium, vitamins B1 , B3 , B6 , B12 and C contribute to normal psychological function • Vitamin B5 contributes to normal intellectual performance • Iodine and zinc contribute to normal cognitive function 7 . IMMUNE SYSTEM • Vitamins A, C, D, B6, B12, folate, zinc and selenium contribute to the normal function of the immune system

Confidential – June 2014

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MultiBetix benefits MultiBetix (box of 60 capsules), with 2 capsules per day, is a complete nutritional supplement, that contains alpha lipoic acid, lutein and DHA

Confidential – June 2014

29

MultiBetix vs Multicentrum MULTIBETIX COMPETITIVE ADVANTAGES

MULTIBETIX

MULTICENTRUM

Carbonate de calcium, oxyde de magnésium, acide alpha-lipoïque, acide L-ascorbique (vitamine C), Omega 3 DHA (acide docosahexaénoïque), agent d’enrobage, anti-agglomérants : stéarate de magnésium (E470b), silice colloïdale et talc, nicotinamide (niacine), citrate de zinc, éthyle DLalpha-tocophérol (vitamine E), Dpantothénate de calcium (acide pantothénique), lutéine, riboflavine (vitamine B2), mononitrate de thiamine (vitamine B1), chlorhydrate de pyridoxine (vitamine B6), sulfate de manganèse, acétate de rétinol (vit.A), acide ptéroilmonoglutamique (vitamine B9), l’iodure de sodium, Dbiotine (biotine), sélénite de sodium, chlorure de chrome (III), cholécalciférol (vit.D), cyanocoalamine (vitamine B12).

Calcio fosfato bibasico, Magnesio ossido, Addensante: Cellulosa microcristallina, Potassio cloruro, Acido Ascorbico, Fumarato ferroso, Vitamina E acetato, Dye opadry orange, Polivinilpirrolidone, Niacina, Biotina, Zinco ossido, Beta-carotene, Manganese solfato monoidrato, Calcio pantotenato, Luteina, Acido stearico, Magnesio stearato, Vitamina A acetato, Silicio biossido, Piridossina cloridrato, Tiamina mononitrato, Rame solfato, Riboflavina, Fillochinone, Lattosio, Acido folico, Potassio ioduro, Cromo cloruro, Cianocobalamina, Sodio molibdato diidrato, Sodio selenato, Colecalciferolo.

Multibetix has vitamins, minerals, lipoic acid (not present in Multicentrum composition), lutein and DHA (not present in Multicentrum composition). Besides, it does not contain Copper, Iron and Vit.K (beause if consumed in excess they can aggravate the complications of Diabetes)

Presentation

60 capsules

30 tablets

Dosing

2 per day

1 per day

Price: Minimal difference, considering what Multibetix offers to people with diabetes

Public price

€12.95

Composition

Conclusion:

€11.90

Confidential – June 2014

Multicentrum is a simple food supplement for every healthy person but also for specific profile (age, sport, cardio, ...)

Multibetix is specific for the preventive treatment of diabetes’ complications

30

MultiBetix vs Supradin MULTIBETIX COMPETITIVE ADVANTAGES

MULTIBETIX

SUPRADIN

Carbonate de calcium, oxyde de magnésium, acide alpha-lipoïque, acide L-ascorbique (vitamine C), Omega 3 DHA (acide docosahexaénoïque), agent d’enrobage, anti-agglomérants : stéarate de magnésium (E470b), silice colloïdale et talc, nicotinamide (niacine), citrate de zinc, éthyle DLalpha-tocophérol (vitamine E), Dpantothénate de calcium (acide pantothénique), lutéine, riboflavine (vitamine B2), mononitrate de thiamine (vitamine B1), chlorhydrate de pyridoxine (vitamine B6), sulfate de manganèse, acétate de rétinol (vit.A), acide ptéroilmonoglutamique (vitamine B9), l’iodure de sodium, Dbiotine (biotine), sélénite de sodium, chlorure de chrome (III), cholécalciférol (vit.D), cyanocoalamine (vitamine B12).

Vitamina A (in forma di Vit. A palmitato tipo 250 CWS) 3.333 U.I., tiamina nitrato (Vit. B1) 20 mg, riboflavina (Vit. B2) 5 mg, piridossina cloridrato (Vit. B6) 10 mg, nicotinamide (Vit. PP) 50 mg, calcio pantotenato 11,6 mg, biotina (Vit. H) 1,8 mg, cianocobalamina (Vit. B12) 5 mcg, acido ascorbico (Vit. C) 150 mg, colecalciferolo ( in forma di vit. D3tipo 100 CWS) 400 U.I., alfa-tocoferolo acetato (in forma di Vit. E 50% tipo SD) 10 mg, calcio (in forma di calcio fosfato e calcio pantotenato) 51 mg, magnesio (in forma di magnesio ossido leggero e magnesio stearato) 18,5 mg, fosforo (in forma di calcio fosfato) 23,8 mg, ferro (in forma di ferroso solfato) 10 mg, manganese (in forma di manganese solfato monoidrato) 0,5 mg, rame (in forma di rame solfato anidro) 1,0 mg, molibdeno (in forma di sodio molibdato diidrato) 0,1 mg, zinco (in forma di zinco solfato monoidrato) 0,5 mg.

Multibetix has vitamins, minerals, oligoelements, lipoic acid, lutein and DHA. Supradin contains only vitamins, minerals and oligoelements.

Presentation

60 capsules

30 tablets

Dosing

2 per day

1 per day

Public price

€12.95

The different price is justified by the benefits Multibetix offers to people with diabetes

Composition

Conclusion:

€9.80 Confidential – June 2014

Multibetix does not contain Copper, Iron and Vit.K (beause if consumed in excess they can aggravate the complications of Diabetes) Supradin is a simple multivitamins for sportive and old people, to correct micronutrient deficiency.

Multibetix is specific for the preventive treatment of diabetes complications

31

Class of 2014 products

A.

Understanding diabetes

B.

Complications of diabetes

C.

Harmonium response

D.

MultiBetix

E.

NeuBetix, food supplement

F.

NeuBetix, Roll-on

G.

ViuBetix

H.

DolBetix

I.

NutriBetix

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

Confidential – June 2014

32

What is Neuropathy?

Peripheral neuropathy is a damage that occurs in peripheral nerves, resulting in pain, numbness, tingling or burning sensation. Neuropathy usually starts along the longest nerves of feet and hands.

According to the Neuropathy Association, there are several types of neuropathy, such as diabetes, compressive, hereditary, alcohol or drug induced, cancer-related, gastrointestinal food-related neuropathies.

Most peripheral neuropathy approaches are aimed at limiting damage and controlling symptoms • • •

The first line of treatment for any type of neuropathy is to treat the underlying cause, such as diabetes, abstention from alcohol or drugs, or treating a nutritional deficiency.

Physical therapy may be helpful in some cases of neuropathy, especially if it is the result of a physical cause such as an accident or pinched nerve.

Painkillers can be used to effectively manage painful neuropathy

Confidential – June 2014

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Diabetics Neuropathy Diabetic peripheral neuropathy (NDP) is associated with serious morbidity and mortality and a marked decrease in quality of life. This condition is characterized by pain, paresthesias and sensory loss affects up to 50 % of patients with diabetes.

In absolute terms, the estimated overall prevalence of diabetes of 472 million people by year 2030, NDP will affect 236 million patients worldwide. The costs associated with the disease are also high. It is estimated that in the U.S. the cost associated with the NDP is 10 900 million per year. These data indicate that NDP, along with foot ulcers and neuropathic pain, far from being a benign anomaly, is a challenge for the medical profession and for society.

TREATMENT OF PAIN INDUCED BY NDP

The current therapeutic approach to painful DPN in first line is to achieve and maintain blood glucose levels as close as possible to normal. However many patients with diabetes, especially those with type 2 diabetes, find it really difficult to meet this goal.

Beyond glycemic control, little progress has been made in the development of compounds that may stop the neuropathic process. Although several agents are currently being investigated, only a powerful antioxidant, alpha lipoic acid, has shown some utility and is already used in some countries.

Confidential – June 2014

34

Why NeuBetix?

MARKET NEED Diabetic neuropathy is one of the most prevalent complications in this population. It is a serious complication that affects quality of life of these patients and the current treatments do not always meet their needs.

WHAT IS NEUBETIX? It is a food supplement which composition has a proven action in prevention and treatment of diabetic neuropathy.

It contains 6 nutrients (vitamins, minerals, antioxidants and others), including Alpha Lipoic Acid, in order to facilitate the following physiological functions: • NERVOUS SYSTEM FUNCTION • ANTIOXIDANT FUNCTION • PAIN RELIEF • CUTANEOUS COMFORT

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com Confidential – June 2014 wwww.reypcglatam.com

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NeuBetix qualitative composition Folic acid (Vit B9) Alpha-lipoic acid Pyridoxal phosphate (Vit B6) Pantothenic acid (Vit B5) Tiamin (Vit B1) Cyanocobalamin (Vit B12)

Confidential – June 2014

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

36

Neubetix, tayored for diabetics!

Folic Acid •

•

Deficiency of folate has been linked to a wide variety of nervous system problems, including general mental fatigue, nervous system problems in the hands and feet among others.

Has also been attributed to helping with vascular disease in people with diabetes

Alpha-lipoic acid (ALA) – claims not authorized by EC regulation • • •

Increases insulin sensitivity and help reduce blood sugar and lipids Helps reduce the symptoms of peripheral neuropathy Provides relief from the pain, burning, tingling and numbing caused by diabetic neuropathy Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

Confidential – June 2014

37

NeuBetix benefits NeuBetix (box of 30 capsules), with a capsule per day, is a targeted nutritional supplement on nervous system, which adds alpha lipoic acid and folic acid to vitamins, that

Confidential – June 2014

38

NeuBetix vs Tiobec Retard NEUBETIX

Composition

Agente di rivestimento: gelatina, acido alfa lipoico, antiagglomerante: fosfato di calcio bibasico, silice colloidale, pantotenato di calcio (vitamina B5), piridossal5-fosfato (vitamina B6), tiamina (vitamina B1), acido folico (vitamina B9), cianocobalamina (vitamina B12).

Conclusion:

TIOBEC RETARD

Acido alfa-lipoico (acido tiottico), agenti di rivestimento: idrossipropilmetilcellulosa, gomma lacca, acido stearico; agenti di carica: dicalcio fosfato, cellulosa microcristallina; antiagglomeranti: biossido di silicio, beenato di glicerolo, talco, magnesio stearato (vegetale); Acido ascorbico, gelatina alimentare, Vitamina E acetato (DL-alfa tocoferil acetato, gelatina), Nicotinamide, Piridossina cloridrato, colorante: E171, Tiamina nitrato, Vitamina B2 (Riboflavina, amido di mais), Vitamina B12 (Cianocobalamina, maltodestrine), Acido folico.

NEUBETIX COMPETITIVE ADVANTAGES Amount of ALA Vit B5

Presentation

30 tablets

40 tablets

Dosing

1 per day

1-2 per day

Neubetix: no constraint

Public price

€14.95

€26.06

Neubetix: cheaper

Confidential – June 2014

39

NeuBetix vs Neulenic 300 NEUBETIX

NEULENIC 300

Agente di rivestimento: gelatina, acido alfa lipoico, antiagglomerante: fosfato di calcio bibasico, silice colloidale, pantotenato di calcio (vitamina B5), piridossal-5-fosfato (vitamina B6), tiamina (vitamina B1), acido folico (vitamina B9), cianocobalamina (vitamina B12).

Acido alfa lipidico, olio di soia, gelatina alilmentare; agente di resistenza: glicerolo;emulsionan te: trigliceridi degli acidi grassi, lectina di soia; antiagglomerante: magnesio stearato; umidificante: poliglicerolo oleato; colorante: e 172.

Presentation

30 tablets

30 tablets

Dosing

1 per day

1 per day

Public price

€14.95

Composition

€19.90

Confidential – June 2014

NEUBETIX COMPETITIVE ADVANTAGES Neubetix offers: -B1, B5, B6 and B12 vitamins -Folic acid -Lipoic acid The combination of alfa lipoic acid and vitamins faciltates the normal function of the nervous system and glucose metabolism.

Neubetix: suitable composition with a cheaper price

40

NeuBetix vs Licofor

Composition

NEUBETIX

LICOFOR

Agente di rivestimento: gelatina, acido alfa lipoico, antiagglomerante: fosfato di calcio bibasico, silice colloidale, pantotenato di calcio (vitamina B5), piridossal5-fosfato (vitamina B6), tiamina (vitamina B1), acido folico (vitamina B9), cianocobalamina (vitamina B12).

Olio di pesce 80% in Omega-3, Gelatina alimentare, Olio di semi di Oenothera (Oenothera Biennis L.) al 10% in GLA, Agente di resistenza: Glicerolo, Vitamina C (Acido Ascorbico), Tagetes (Tagetes erecta L.) fiori e. s. al 20% in Luteina (su maltodestrine da grano), Acido lipoico 95% (su magnesio stearato), Addensante: Glicerilmonostearato, Pomodoro frutto (Solanum lycopersicum L.) estratto 18% in Licopene, Resveratrolo (da Polygonum cuspidatum Siebold, radici), Emulsionante: Lecitina di soia, Tagetes (Tagetes erecta L.) fiori e.s. al 10% in Zeaxantina (su maltodestrine da grano), Vitamina E naturale 1000 IU/G (d-alfatocoferolo in olio di girasole e soia). Coloranti: E172.

Conclusion: Presentation

30 tablets

30 tablets

Dosing

1 per day

1 per day

Public price

€14.95

Confidential €24.17 – June 2014

NEUBETIX COMPETITIVE ADVANTAGES Lipoic Acid amount Licofor is a omega-3 food supplement, whereas Neubetix is a Lipoic acid supplement Neubetix contains Vit. B group and folic acid, whereas Licofor contains Vit. E and C. Neubetix has not colouring agents in its composition

41

Neubetix: cheaper price

Class of 2014 products A.

Understanding diabetes

B.

Complications of diabetes

C.

Harmonium response

D.

MultiBetix

E.

NeuBetix

F.

NeuBetix Roll-on, dermocosmetic

G.

ViuBetix

H.

DolBetix

I.

NutriBetix

Confidential – June 2014

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

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Cutaneous & sensitive symptoms of NPD Symptoms are related to the type of affected nerve and may be seen over a period of days, weeks, or years Damage to large sensory fibers lessens the ability to feel vibrations and touch, resulting in a general sense of numbness, especially in the hands and feet •

Many patients cannot recognize by touch alone the shapes of small objects or distinguish between different shapes.

Damage to smaller sensory fibers without myelin can interfere with the ability to feel pain or changes in temperature •

People may fail to sense that they have been injured from a cut or that a wound is becoming infected.

Pain receptors in the skin can also become oversensitized, so that people may feel severe pain from stimuli that are normally painless •

for example, some may experience pain from bed sheets draped lightly over the body

Neuropathic pain is often worse at night, seriously disrupting sleep and adding to the emotional burden of sensory nerve damage Confidential – June 2014

43

Why NeuBetix Roll-on?

MARKET NEED Many times in patients with diabetic peripheral neuropathy, symptoms such as pain does not go away and you need to use adapted topical products.

Besides, diabetics want to use a product which brings relief once applying.

Last but not least, one of the most common problems when applying cream with hands, are the possible side effects if hands touch eyes or cream enters a opened wound and light.

WHAT IS NEUBETIX ROLL-ON? It is a topical product for the treatment of symptoms (pain) of diabetic neuropathy, which is applied directly thanks to a practical presentation, a roll-on, avoiding touching it with your hands and avoiding the risk of side effects if applied the product on eyes, mucous membranes or wounds.

• SYMPTOMATIC RELIEF OF PAIN

• ACTING ON PERIPHERAL SENSORY NERVE FIBERS • INDUCING NEUROGENIC INFLAMMATORY RESPONSES • RELIEVES ITCHING AND BURNING PAIN

Confidential – June 2014

44

NeuBetix Roll-on Qualitative composition Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

MENTHOL CAMPHOR VITIS VINIFERA LEAF EXTRACT CAPSICUM FRUTESCENS RESIN HELIANTHUS ANNUUS SEED OIL

PRUNUS AMYGDALUS DULCIS OIL

No allergens

Do not use for children below 6 years

Confidential – June 2014

45

NeuBetix Roll-on Properties of ingredients OLEORESIN CAPSICUM

• Symptomatic relief of muscle and joint pain localized • Properties rely on its ability to act on peripheral sensory nerve fibers, inducing neurogenic inflammatory responses, on itching and on burning pain.

• Repeated use decreases thee production of a neurotransmitter involved in the transmission of painful stimulus, substance P: desensitization of the painful area. This effect is reversible • Acts locally and do not have the disadvantages of systemic application

CAMPHOR

• Topically, camphor has local anesthetic properties, analgesic and antipruritic • Camphor acts by activating the receptor TRPV3 (Transient Receptor Potential Vainillin 3), a receiver of the TRP family that is expressed on keratinocytes, on the dorsal root ganglia and spinal cord • This receptor plays a role in the hyperalgesia of the inflamed tissue and skin sensitization

MENTHOL

• • • •

VITIS VINIFERA LEAF EXTRACT

Menthol is a white crystalline substance, main ingredient of peppermint oil Brings a cooling / refreshing sensation in the mouth and nostrils. It is a sedative used to treat neuralgia Menthol has analgesic / anesthetic, used in the treatment of muscle pain When applied to the skin, menthol causes a cold effect

• Brings venotonic effect , vasoprotective , astringent and diuretic • One of the most accredited medicinal plants acting on the venous system • Consequent reduction in permeability by strengthening the walls of veins and oedema, thus avoiding these circulatory disorders

Confidential – June 2014

46

NeuBetix Roll-on benefits NeuBetix Roll-on of 50mL, with its practical presentation, is made for diabetics in order to bring to them relief when facing cutaneous discomfort – LOCAL ACTION

Confidential – June 2014

47

NeuBetix Roll-on competitive scenario

Confidential – June 2014

48

Class of 2014 products

A.

Understanding diabetes

B.

Complications of diabetes

C.

Harmonium response

D.

MultiBetix

E.

NeuBetix

F.

NeuBetix, Roll-on

G.

ViuBetix, food supplement

H.

DolBetix

I.

NutriBetix

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

Confidential – June 2014

49

What is Retinopathy?

Retinopathy is due to persistent or acute damage to the retina of the eye. Ongoing inflammation and vascular remodeling may occur over periods of time where the patient is not fully aware of the extent of the disease.

Frequently, retinopathy is an ocular manifestation of systemic disease. Causes of retinopathy include but are not limited to: •

Diabetes mellitus, which causes diabetic retinopathy

•

Arterial hypertension, which causes hypertensive retinopathy

•

Retinopathy of prematurity due to prematurity of the newborn (under the 9 months of human pregnancy)

•

Radiation retinopathy due to exposure to ionizing radiation

Angiogenesis, the sprouting of new vessels is the hallmark precursor that may result in blindness or severe vision loss particularly if the macula becomes affected

Confidential – June 2014

50

Diabetes and Retinopathy Diabetic retinopathy is a common complication of diabetes which affects up to 80 percent of all patients who have had diabetes for 10 years or more.

Occurs when high blood sugar levels damage the cells at the back of the eye, the retina. If not treated, can lead to blindness.

•

The retina is the light-sensitive lye of cells at the back of the eye and converts light into electrical signals

•

The signals are sent to the brain through the optic nerve in order to be interpreted

•

To work effectively, the retina needs a constant supply of blood

•

A continuously high blood sugar level can lead to damages on the tiny blood vessels. They can become blocked or even leak

Research indicates that at least 90% of these new cases could be reduced if there was proper and vigilant treatment and monitoring of the eyes Confidential – June 2014

51

Why ViuBetix?

MARKET NEED Diabetic retinopathy is one of the most prevalent complications in this population.

Diabetic retinopathy affects up to 80 %t of all patients who have had diabetes for 10 years or more. Diabetics have special nutritional needs, there is a direct relationship between a balanced diet and reducing the complications of diabetes.

WHAT IS VIUBETIX? It is a nutritional supplement which composition has proven effective in prevention and treatment of diabetic retinopathy It contains 7 nutrients (vitamins, minerals, antioxidants and others), including lutein and zeaxanthine, in order to facilitate the following physiological functions: • VISION FUNCTION

• ANTIOXIDANT FUNCTION

Confidential – June 2014

52

ViuBetix qualitative composition Lutein Quercertin ES Blueberry Magnesium Selenium Vit A Vit C Vit E Zinc

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

Confidential – June 2014

53

Viubetix, shaped for diabetics!

Lutein – claims not authorized by EC regulation • • • •

Reduces the level of oxidative stress markers in diabetes Prevents changes in the retina and hippocampus in diabetes Inhibits the development of cataracts in diabetes Perspectives: is a candidate for preventing infections in diabetes

Lutein protects the eyes from harmful high-energy light waves. Studies have shown that high levels of lutein & zeaxanthin are associated with better vision, especially in dim light or where glare is a problem.

Quercetin • •

Important flavonoid with antioxidant and anti-inflammatory activity Is used for treating conditions of the heart and blood vessels

ES Blueberry • •

Contains anthocyanins Clinical studies have shown that anthocyanins decrease the biosynthesis activity of the connective tissue −

prevent injuries in diabetics eyes

Confidential – June 2014

54

ViuBetix benefits ViuBetix (box of 30 capsules), with a capsule per day, is a targeted nutritional supplement on vision system, adding lutein, xeazanthine and quercetin to vitamins, that

Confidential – June 2014

55

ViuBetix Roll-on competitive scenario

Confidential – June 2014

56

Class of 2014 products

A.

Understanding diabetes

B.

Complications of diabetes

C.

Harmonium response

D.

MultiBetix

E.

NeuBetix

F.

NeuBetix, Roll-on

G.

ViuBetix

H.

DolBetix, dermocosmetic

I.

NutriBetix

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

Confidential – June 2014

57

Fingertip lancing impact on skin Lancing = an essential part of successful diabetes management Regular lancing of the fingertips for sampling skin blood results in thickened skin in more than half of the individuals* • •

The skin changes are the more frequent the higher the lancing frequency is at a given skin area Skin thickening is annoying for the patient as it makes blood sampling more difficult and gives an unpleasant sensation of tension

Often the skin at the lancing sites was also rough and yellowish discoloured* Lancing impact depends on lancet quality by repeatedly injuring a multitude of cells and nerve endings and leaving blood within the punctured wound* • •

Many of the injured cells and of the blood constituents release a multitude of mediators that activate immunologic and repair processes for defence and healing In susceptible individuals, an excessive activity of these processes may lead to hypertrophy of the skin

*Fruhstorfer H. Frequent lancing for monitoring blood glucose may cause skin changes. Practical Diabetes Int 2006

THE BEST REMEDY FOR THE HYPERTROPHIC SKIN CHANGES IS PREVENTION Confidential – June 2014

58

Why DolBetix Roll-on?

MARKET NEED One of the everyday activities of the diabetic patient is to control blood sugar levels and this action causes discomfort and complications is the determination of capillary glucose, by using a lancet device that punctures the fingertip to obtain a drop of blood.

This action, repeated several times every day, for many years leads to serious damage in the fingers

WHAT IS DOLBETIX ROLL-ON? DolBetix is the first topical product specifically designed to prevent and treat these injuries faced by millions of patients. It is effective, natural and safe and acts, thanks to the synergic action of its ingredients, on the key points of this daily assault.

• REPAIRING THE DAMAGE FROM THE WOUND OF THE LANCET • REDUCING THE CALLUS • MINIMIZING MICROVASCULAR INJURY • REDUCING THE RISK OF LOCAL INFECTION • PRODUCING A SENSE OF RELIEF • ACTING ON INFLAMMATION, AND EDEMA • ACCELERATING THE PROCESS OF SCAR • HYDRATING AND IMPROVING THE APPEARANCE

Confidential – June 2014

59

DolBetix Roll-on Qualitative composition UREA ALOE BARBADENSIS ARNICA MONTANA VITIS VINIFERA ROSA MOSCHATA

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

HAMAMELIS VIRGINIANA MENTHOL KARITE

No allergens

Do not use for children below 3 years Confidential – June 2014

60

DolBetix Roll-on Properties of ingredients (1/2) UREA

• Prevents water loss through the skin • Improve the skin cells flaking • Emollient action

• • • ALOE • BARBADENSIS •

ARNICA MONTANA

Antiseptic, antibacterial, anti-inflammatory and regenerative properties of the skin Prevents infection Facilitates regeneration of damaged cells Reduces inflammation and pain Increases blood flow, encouragin cell renewal

• Softens, moisturizes, sooths, regenerates damaged skin (emollient) • Effectively stimulates regeneration on local inflammation areas • Helps the removal of internal bleedings

• Brings venotonic effect , vasoprotective , astringent and diuretic • One of the most accredited medicinal plants acting on the venous system VITIS VINIFERA • Consequent reduction in permeability by strengthening the walls of veins and oedema, thus avoiding these circulatory disorders LEAF EXTRACT

Confidential – June 2014

61

DolBetix Roll-on Properties of ingredients (2/2) • • • • ROSA MOSCHATA • •

HAMAMELIS VIRGINIANA

MENTHOL

Activation of cellular metabolism Antioxidant and anti-free radicals Acts of the three levels of skin hydration Accelerates and regulates the cell regeneration rate Acts on the immune system by activating the body's defense mechanisms Increases the synthesis of collagen and elastin

• Has a strong healing, anti-inflammatory action and tension, thanks to the astringent action of its tannins • Vasoconstrictor effect / remove small redness of the skin • Provide a numbing effect when applying • Helps to prevent new infections

• Menthol is a white crystalline substance, main ingredient of peppermint oil • Brings a cooling / refreshing sensation in the mouth and nostrils. It is a sedative used to treat neuralgia • Menthol has analgesic / anesthetic, used in the treatment of muscle pain • When applied to the skin, menthol causes a cold effect

Confidential – June 2014

62

DolBetix Roll-on benefits DolBetix, with its practical presentation of Rol-on 10mL, is made for diabetics in order to give them relief and to prevent skin complications after lancing – LOCAL ACTION

Confidential – June 2014

63

DolBetix vs Cicaplast baume B5 DOLBETIX

Composition

Aqua, Cetearyl Glucoside, Cetearyl Alcohol, Glyceryl Stearate, Prunus Amygdalus dulcis oil, heliantus annus seed oil, menthol, peg40 hydrogenated castor oil, Urea, Aloe Barbadensis leaf extrac,t, hamamelis virginiana, butyrospermum parkii butter, arnica montana extract, vitis vinifera leaf extract, rosa damascena absolute, triethanolamine.

Conclusion:

CICAPLAST BAUME B5

DOLBETIX COMPETITIVE ADVANTAGES

Aqua / Water, Hydrogenated Polyisobutene, Dimethlcone, Glycerin, Butyrospermum Parkii Butter / Shea Butter, Butylene Glycol, Aluminum Starch Octenyl Succinate, Pr0panedi0l, Panthenol, Cetyl Peg/Ppg-10/1 Dimethlcone, Tristearin, Zinc Gluconate, Madecassoside, Manganese Gluconate, Magnesium Sulfate, Dis0dium Edta, Copper Gluconate, Acetylated Glycol Stearate, P0lyglyceryl-4 Isostearate, Sodium Benzoate, Phenoxyethanol, Chlorhexidine Digluconate,

Dolbetix is specific for fingertips damage (eg: its practical roll-on format), instead of Cicaplast, that is more generic for floushed skin or wounds and it is used for children.

Dolbetix is more comfortable and suitable for fingertips, damaged by glycaemic measurements

Titanium Dioxide.

Presentation

Stick roll-on (specific for fingers) – 10 ml

Cream (tube) – 40 ml

Application

When necessary

2 times per day

Public price

€9.90

Confidential – June 2014 €9.61

Dolbetix contains: Arnica Montana and Hamamelis Virginiana (decongestant action), Fatty acids and karité (soothing action), Vitis Vinifera extract (reconstruction of tissues), menthol (freshness sensation)

64

Class of 2014 products

A.

Understanding diabetes

B.

Complications of diabetes

C.

Harmonium response

D.

MultiBetix

E.

NeuBetix

F.

NeuBetix, Roll-on

G.

ViuBetix

H.

DolBetix

I.

NutriBetix, specific food

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com Confidential – June 2014 wwww.reypcglatam.com

65

Diabetes and weight/glycemia control Healthy diet is critical in weight management, especially for Type 2 diabetes When choosing daily food, people with diabetes should pay more attention to balance their meals and ingest the correct amount and quality of carbohydrates It is proven that a Low Glycemic Index Diet can improve the insulin sensitivity in Type 2 diabetes (in some cases with a complete reversion of the illness) and allow Type 1 patients to reduce their daily drug therapy A Low Glycemic Index Food style will also help to prevent diabetes complications, avoiding overweight/obesity and excess of sugar levels in the blood

In many cases, patients are not compliant to the nutritional guidelines because they are perceived as strict, stressful and privative Confidential – June 2014

66

Why Nutribetix?

MARKET NEED Diabetics need to follow a healthy diet in order to manage their weight and prevent future complications. Bad food habits and overweight strongly contribute to Type 2 diabetes onset.

Both types of diabetics also need to pay attention to the quality and amount of carbohydrates they introduce every day, while important self-denial and food deprivations that can bring to a reduced quality of life, combined with a decreased compliance to the dietotherapy.

WHAT IS NUTRIBETIX? It is a Low Glycaemic Index Food selection, composed of products chosen among the most prohibitive foods for the diabetic population, later re-thought and adapted to meet their needs. With their balanced composition, they can have an effective action in the blood glucose management, weight control and prevention of diabetes complications.

Every food product is designed to be suitable for diabetics’ nutritional needs.

Confidential – June 2014

67

Nutribetix benefits NutriBetix, with an higher content of vegetable protein, combined with an accurate choice of healthy fats and good carbohydrates contributes to:

Confidential – June 2014

68

Cacao Mousse An example of NutriBetix Presentation: Box containing 5 sachets (monodoses) - 135 g Description: The Cacao Mousse is the perfect solution for a pleasant break or a fanciful dessert. Its interesting nutritional profile allows a sweet sin with only 98 kcal. The natural sweeteners used, such as Stevia, allow to taste a delicious snack with an incredibly low glycemic index. Without hydrogenated fats, it also has a low saturated fat content and about 3 g of dietary fiber. It is thought for a quick and healthy snack: ready in only a few minutes and without the need to cook it. It can be prepared with cold or hot water.

Confidential – June 2014

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

69

Cacao Mousse Properties of ingredients (1/2) SOY PROTEINS

• High biological value vegetable proteins. The quality of our proteins guarantees they will cover all the aminoacids’ requirements for children and adults.

• Vegetable proteins are important to slow down the gastric emptying and delay the absorption of carbohydrates. Besides, they contribute to prevent sarcopenia in old people and support the growth in the youngsters.

• Our dietary products are not hyper-protein foods, according to the necessity of a balanced mix of nutrients in the diabetics’ daily diet.

FRUCTOSE, ERYTHRITOL & STEVIA

• All our sweet products are produced by using fructose, erythritol and Stevia as educorants. Their high sweetening power, combined with their natural origin, allow us to offer excellent and healthy sweet choices to people affected with diabetes.

• The fructose’s low glycaemic index doesn’t affect post prandial glycaemia. Erithritol and Stevia are not metabolized by organism, so they contribute to the sweet taste without moving blood sugar levels.

DIETARY FIBRE

• The high fibre content in all our food range helps people to feel full for longer time and it decreases the glycamic index of the whole product, guaranteeing a smaller carbs absorption and an improved bowel’s function.

• A correct daily intake of fibre may prevent also overweight and obesity, strictly related to diabetes’ complications.

Confidential – June 2014

70

Cacao Mousse Properties of ingredients (2/2)

CACAO POWDER

• Our ingredients are chosen for their high quality. The powder used in our Mousse (as the aromas used in our other products) is extracted by high quality cacao grains.

• We never use colouring agents, artificial aromas or preservatives to guarantee a true taste and the best quality, starting from the choice of our recipes’ ingredients.

SUNFLOWER OIL (high oleic acid content)

• According to the dietary guidelines of a healthy daily diet, we always try to limit saturated fatty acids (contained in palm or coconut oil, used in the majority of products on the market) and opt for healthy fatty acids.

• The composition of sunflower oil with high oleic acid content is more similar to the olive oil’s one than to the normal sunflower oil’s composition, ensuring the best nutritional compounds for a balanced snack.

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com Confidential – June 2014

71

Cacao Mousse Claims

HYDROGENATED FAT FREE

WITH STEVIA natural edulcorant with no effect on the glycaemia Confidential – June 2014

WITHOUT GLUTEN

72

NutriBetix – Vanilla Mousse Low Glycaemic Index Another perfect solution to satisfy the desire of a sweet and delicious snack or dessert, without breaking the healthy diet’s rules.

Its low glycaemic index and the high fibre content provide great satiety and an excellent blood sugar control.

The absence of preservatives, colouring agents and articial sweetenings, ensure the natural quality of the product. The vegetable protein content, combined with an accurate choice of good carbohydrates and healthy fats guarantees a balanced solution for sweet moments.

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

Managing diabetes is easier and…sweeter!

Confidential – June 2014

73

NutriBetix – Breakfast mix Low Glycaemic Index This a balanced mix of cereal flakes and soy nuggets, ideal to start the day with a healthy breakfast. It can be added in your cup of milk or yogurt and it is perfect in vegetable soups, too.

Limited calories, high vegetable protein content and high dietary fiber amount are its best nutritional features. Additives, coloring agents and hydrogenated fatty acids have been excluded from the recipe. A long shelf life is guaranteed by a modified atmosphere packaging, instead of using artificial preservatives.

Every serving of our Breakfast mix contains 1.1 Betaglucans from barley, that contribute to the Linea disponible para Latino America maintenance of normal blood cholesterol levels, Mas informacion : REY PCG Latam important issue for the prevention of diabetes’ Juan Carlos Rey complications.

57-3132910715 Managing diabetes is easier and…sweeter!

Confidential – June 2014

juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

74

NutriBetix – Bread / Pizza flour Low Glycaemic Index The idea is to offer to diabetic people the possibility to maintain an high quality of life, without avoding the most tasty and prohibitive foods, such as pizza and bread.

The high fibre and the resistant starch content in our flour allow the diabetics to eat without giult-feelings and effects on their post-prandial glycaemia.

The mix for bread and pizza does not contain gluten.

Confidential – June 2014

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

75

NutriBetix vs Competitors LOW GLYCAEMIC INDEX BEST SELLER FOOD RANGES (PHARMACY CHANNEL) NutriBetix Low Glycaemic Index

Diabel Not specified!

Enerzona Not specified!

Low Glycaemic Load High protein content High fibre content

Inulin: gastrointestinal discomforts

Clean label

Preservatives

Healthy fatty acids

Palm oil, margarine

Natural sweetenings

Palm oil (bars)

Acesulfame K, saccharin, maltitol

Gluten free

Target

Diabetes Type 1 Diabetes Type 2 Gestational Diabetes Coeliac people with Diabetes

Diabetes Type 1 Diabetes Type 2 Gestational Diabetes

Confidential – June 2014

Sportmen, Weight control.

76

Harmonium portfolio New Products

Linea disponible para Latino America Mas informacion : REY PCG Latam Juan Carlos Rey 57-3132910715 juancarlos.rey@reypcglatam.com wwww.reypcglatam.com

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