•Autoantibodies •Genes Transmitter •Signal A IR ( U 100 300 400 500 200 / m L ) Insulin Sensitivity A IR ( U 100 300 400 500 200 / m L ) Membrane Hyperpolarised ATP does not lead to K ATP channel closure No calcium influx No insulin secretion V59 Selectivity Filter I296 ATP Membrane Slide Helix Haider, Sansom and Ashcroft Outside Inside 75% Transcription factors 11% MODY x 4% HNF4 61% HNF1 <1% NeuroD1 <1% IPF1 Ellard, Frayling et al Diabetes 2001
