Spring 2007

UPDATE FROM BURNHAM - FLORIDA Q SCIENTIST OF THE YEAR

Burnham / UCSB Affiliation TEAM BURNHAM Storms Phoenix Marathon ERNEST CHIPMAN: A Legacy

UNDERSTANDING THE HEART

Volume 4 | Number 1 | 2007

Burnham Report

BURNHAM REPORT

IN THIS ISSUE

President’s Message........................................................... 1 RESEARCH MATTERS John C. Reed, M.D., Ph.D. President and CEO

Understanding the Heart....................................................... 2

Karin Eastham Executive Vice President and COO

Burnham Announces Affiliation with UCSB .......................... 4

Blair Blum Senior Vice President, External Relations

News & Notes ..................................................................... 6

Edgar Gillenwaters Vice President, External Relations

Update from Burnham - Florida............................................ 7

Chris Lee Director, External Relations Nancy J. Beddingfield Editor, Burnham Report Director, Public Affairs MALINDA DANZIGER Coordinator, Marketing and Public Relations

Contributing Photographers: Martin Mann, Tim Middleton, Annabelle Mery, Muffy Walker, Amber Evans, Colleen O’Keefe, Jocelyn Wyndham and Malinda Danziger

The Burnham Report is published by the Burnham Institute for Medical Research. We welcome your input.

Please send comments or requests to info@burnham.org.

PHILANTHROPY MATTERS

A Message from Blair Blum . ............................................... 8 The Legacy Society Profiles Eugene “Ernest” Chipman . ....... 9

Team Burnham Storms Phoenix ......................................... 10 Rock n’ Roll Marathon Making the Most of Your Assets.......................................... 12 Wish List: Stem Cell Research Center.................................. 12 First and Second Quarter Donations.................................... 13 Calendar of Events............................................................. 14

ON THE COVER

10901 North Torrey Pines Road La Jolla, CA 92037 www.burnham.org

Dr. Mark Mercola, Professor and Developmental Biologist at the Burnham Institute for Medical Research, with heart muscle cells developed from embryonic stem cells.

PRESIDENT’S MESSAGE We remember 2006 as our year

precise delivery into the heart. Dr.

of expansion.

Rolf Bodmer, a geneticist, uses fruit

With great encouragement from the State of Florida and the community of Orlando, Burnham announced plans last summer to establish bi-coastal operations at Lake Nona, Orlando that will grow to 300 people over the next decade. With this issue, we launch a new column, “Update from BurnhamFlorida,” to share our Florida story as it unfolds. We expect to have our first wave of scientists in place and doing research this summer in Orlando.

At year’s end, we announced

Burnham’s affiliation with the University of California at Santa Barbara (UCSB). Burnham-UCSB is home to the “Vascular Mapping Center,” established by Distinguished Professor Dr. Erkki Ruoslahti, focusing on developing applications for vascular “zip codes,” based on unique technology discovered in his laboratory.

Our cover story “Understanding the Heart” presents a sampling of the ways in which Burnham scientists are addressing the world’s number one killer: heart disease. Developmental Biologist Dr. Mark Mercola is learning how to grow cardiac muscle tissue from a single cell. Dr. Erkki Ruoslahti is developing new therapies using peptides discovered in his laboratory to ensure

flies to study heart development and genetically-linked behaviors.

On January 14, 2007, in a true demonstration of heart, our first Team

Burnham for Medical Research stormed the Phoenix Rock n’ Roll Marathon and Half Marathon. We were 34 members strong and raised over $120,000 for medical research at Burnham. You can read more about this inspiring story on page 10. I am grateful for the community spirit that drove our first

Team Burnham and for the new friends and new awareness Burnham gained along the way.

2007 promises to be a year of tremendous progress at Burnham. We are poised to drive discovery research faster than ever. Thank you for your interest. Thank you for your help!

John C. Reed, M.D., Ph.D. President and CEO

RESEARCH MATTERS

Understanding

www.burnham.org

the Heart Heart disease is the single largest killer of men and women. One in three American adults has at least one form of cardiovascular disease – that’s 79,400,000 people. Every 26 seconds – just about the time it will take you to read this paragraph – someone will suffer a coronary event in the United States. And 38 percent of the people who experience a heart attack will die within one year.

Scientists at the Burnham Institute for Medical Research are working on several approaches to lay a foundation of discovery research that will lead to improved treatments, and potential cures, for heart disease. g

ORIGINS OF THE HEART A major obstacle in treating cardiac disease is the heart’s Professor Mark Mercola

inability to rejuvenate, or grow new tissue.

Dr. Mark Mercola’s laboratory studies cardiogenesis in embryos and stem cells in search of ways to promote regeneration of the heart.

Mercola, a developmental biologist, has discovered several natural signals that induce heart muscle formation in embryos and, when applied to stem cells, enhance production of heart muscle cells. The laboratory has also uncovered genes that control the pattern and shape of the heart, such as the size of the atrioventricular canal, derivatives of which are often malformed in congenital heart disease.

“ Development of a heart cell from a stem cell is an incremental process,” says Mercola. “We hope our work will contribute to a new generation of treatments based on replacing damaged heart tissue with healthy heart cells.”

The Mercola laboratory is adapting techniques commonly used in research to develop drugs that search for chemicals stimulating the formation

INTO THE HEART The arteries and blood vessels, or vasculature, servicing the heart are at the epicenter of many cardiac diseases. Dr. Erkki Distinguised Professor Erkki Ruoslahti

Ruoslahti has discovered that the heart vasculature displays

molecular signatures that act as a “zip code” for targeting therapeutic molecules to coronary Using techniques developed in his lab, Dr. Mercola has coaxed human embryonic stem cells into heart cells that resemble a mature human ventricular heart cell.

arteries.

Ruoslahti discovered that cells lining all blood vessels bear receptors unique for each tissue type in the body. His laboratory also discovered a screening method that identifies tiny pieces of

and replication of heart cells. Together with

protein building blocks, called peptides which

Burnham’s Dr. Jeffrey Price, Mercola is

bind specifically to the receptors that define this

working to develop prototype instrumentation

zip code system in the body.

and special assays to screen for drugs that stimulate a cell’s maturing.

Using the combination of embryology and drug discovery approaches, Mercola and his colleagues

“These homing peptides could be useful in directing therapeutic agents,

have discovered molecules that control key steps in

such as drugs and gene therapy

the program leading to the development of heart

vectors, into the heart”

muscle. “Development of a heart cell from a stem Using this system, Ruoslahti and his coworkers

“We are searching for genes, proteins and chemical

recently surveyed the heart and identified

drugs that stimulate small steps along the way

peptides that home specifically into the heart

from immature stem cell to mature heart cell.

vasculature and also identified receptors

We hope our work will contribute to a new generation of treatments based on replacing damaged heart tissue with healthy heart cells.” g

uniquely present in cardiac blood vessels.

“These homing peptides could be useful in directing therapeutic agents, such as drugs and Continued on page 4

www.burnham.org

cell is an incremental process,” says Mercola.

RESEARCH MATTERS

- Heart Research Updates cont.

INTO THE HEART Continued from page 3 gene therapy vectors,

Burnham Announces Affiliation with UC Santa Barbara

into the heart,” said Dr. Ruoslahti.

Burnham-UC Santa Barbara is home to “Vascular Mapping Center,” founded by Erkki Ruoslahti, M.D., Ph.D.

“The high cardiac expression of the receptors suggests that they may be functionally important

Homing peptides line coronary artery.

in the heart. We are conducting further studies to explore their role in cardiac physiology and disease.”

One application for Ruoslahti’s vascular homing system may be in the design of new treatments for atherosclerosis, where fatty substances form a deposit of plaque on the inner lining of the arterial wall.

Heart-homing peptides discovered in his laboratory are being used in the design of nanomedicines, which blend precise engineering, molecule by molecule, with pharmacology, to detect, monitor, treat, and potentially eliminate “vulnerable” plaque, the probable cause of death in sudden cardiac arrest. Nanomedicines hold promise for creating microdevices with multiple

Burnham Institute for Medical Research recently announced an affiliation with the University of California at Santa Barbara. At Burnham-UCSB, Dr. Erkki Ruoslahti, Distinguished Professor and former Burnham President and CEO, has opened the “Vascular Mapping Center,” which is developing applications using the body’s own “zip code system,” based on technology discovered by Ruoslahti.Vascular zip codes are molecular signatures in blood and lymphatic vessels, or vasculature, that are specific to individual tissues and disease sites. One application is the design of nanodevices that home to specific organs and sites of disease.

A partnership of 25 scientists, primarily from Burnham and UCSB, has been recognized by the National Institutes of Health as a “Program of Excellence in Nanotechnology,” with a $13 million grant to design nanotechnologies that detect, monitor, treat, and eliminate “vulnerable” plaque, the probable cause of death in sudden cardiac arrest.

functions and Ruoslahti’s homing peptides may help deliver on that promise. g

“ Nanotechnology is an expanding emphasis in my research,” said Ruoslahti. “The opportunity to work more closely with our collaborators at

UCSB was a key consideration in choosing this location for our Vascular Mapping Center and

www.burnham.org

forging a Burnham affiliation.”

Model Heart

Professor Rolf Bodmer

Dr. Rolf Bodmer and

Recent work from the Bodmer laboratory has

his colleagues at

addressed identifying genetic effects on the physiology

Burnham have engaged

of the aging heart. They discovered a gene called dSUR,

a supermodel for the

expressed in the developing heart that plays a protective

studying the heart:

role against hypoxic stress, or lack of oxygen, and the

Drosophila melanogaster,

susceptibility for heart failure upon electrical pacing of

or the lowly fruit fly.

the heartbeat. They also found that another gene

Medical scientists have long relied on the fruit fly as a model for studying the genetics of embryonic development. It is now known, as Dr. Bodmer proposed a decade ago, that the formation of the cardiac tube, the genesis of the heart, is a similar process in fruit flies and humans.

“We have begun to use the fly heart and the power of Drosophila genetics to understand the genetic and molecular mechanisms underlying aging of cardiac tissue and their contribution to cardiac disorders and arrhythmias.”

Structure of the adult Drosophila heart: Cardiac myofibrils (dark areas) generate contractions and cipher proteins (light areas) in Z-lines link repeated muscle contraction units.

Photography: Annabelle Mery

and genetic events that guide heart development and

called KCNQ, which in humans causes severe cardiac

the consequences of gene mutations. Of the 1,682

arrhythmias when malfunctioning, has a similar function

known human genetic diseases, 75 percent have a

in the fruit fly heart.

homologue, or genetic counterpart, in the fruit fly.

“Because the basic mechanisms of heart development

Genetic similarities between fruit flies and humans

and function are conserved between Drosophila and

include mutant genes that forebode susceptibility

vertebrates,” says Bodmer, “we have begun to use

to heart attacks, genes that play a role in cardiac

the fly heart and the power of Drosophila genetics to

development, cardiac muscle contraction, conduction

understand the genetic and molecular mechanisms

of electrical signals, and regulation of cardiac rhythm.

underlying aging of cardiac tissue and their contribution to cardiac disorders and arrhythmias.” g

www.burnham.org

Bodmer is focused on understanding the molecular

RESEARCH MATTERS

News & Notes

BLOOD’S OWN OXYGEN SENSOR DISCOVERED Dr. Stuart Lipton’s group recently discovered a novel “oxygen sensor motif” consisting of critical cysteine thiol groups controlled by reaction with nitric oxide to form what is termed an S-nitrosylated protein.

Published in the scientific journal Neuron, the collaboration with Dr. Robert Liddington presents both structural and functional data in describing

AMNIOTIC FLUID: A NEW SOURCE FOR STEM CELLS Dr. Evan Snyder, together with colleagues from Wake Forest and Harvard University, recently published new findings showing that amniotic fluid,

the effects on this new molecular oxygen switch. The discovery will open up new ways of designing drugs for the treatment of conditions such as stroke and vascular dementia, working with targets that will activate under hypoxic, or low oxygen, conditions.

the liquid that surrounds and cushions a fetus during pregnancy, may be a useful source of human stem cells. Their report suggests that stem cells can be isolated from the fluid more easily than previously thought and may provide a new source of donor stem cells for medical research. This work was published in the journal Nature Biotechnology.

ARCS names Dr. John Reed as Scientist of the Year Dr. John C. Reed, President and CEO of the

Burnham Institute for Medical Research, will

Keynote Speaker Dr. Christoper Lipinski and Dr. John Reed, SDCCG Director.

be honored as the 2007 Scientist of the Year by the San Diego Chapter of Achievement Rewards for College Scientists (ARCS) Foundation at a ceremony in March. Dr. Reed is being recognized for his contributions to cancer research, AIDS, autoimmunity, stroke and other diseases.

www.burnham.org

The San Diego Chapter of ARCS is one of 14

chapters in the nation dedicated to helping the best and brightest students by providing graduate scholarship support in the natural sciences, medicine and engineering.

OPEN HOUSE FOR SAN DIEGO CENTER FOR CHEMICAL GENOMICS Open House at Burnham’s San Diego Center for Chemical Genomics (SDCCG) welcomed nearly 100 colleagues from the National Institutes of Health (NIH) and the Molecular Libraries Screening Centers Network (MLSCN). SDCCG is one of 10 MLSCN partners funded by the NIH Roadmap

UPDATE FROM BURNHAM - FLORIDA initiative, which together comprise the world’s largest public drug discovery effort. Dr. Christopher Lipinski, one of the foremost experts in drug discovery and and inventor of “Lipinski’s Rule of 5,” provided the keynote speech on “The Innovation

We recently announced Burnham’s plans to establish bi-coastal operations with a campus at Lake Nona, Orlando, Florida. This expansion will allow us to extend our drug discovery capabilities and focus on diabetes and obesity. We are building this operation with the help of many partners in Florida. We will continue to share news from our Florida site as our story unfolds.

Conundrum: An Equal Opportunity Challenge for Academia, Government and Industry.”

NEW INSULIN PATHWAY COMPONENT MAY HOLD KEY TO TREATING DIABETES Dr. Sean Oldham, Ph.D., and his colleagues at

Burnham and the National Institute on Alcoholism and Alcohol Abuse, may have discovered a potential treatment for “metabolic syndrome,” an agingassociated group of disorders that includes insulin resistance, heart disease and high lipid levels.

Using fruit flies bred with a newly created mutant form of the gene TOR (target of rapamycin), Oldham and his colleagues uncovered a possible new

Season Opener As part of Burnham’s Florida expansion, Orlando Magic chairman and philanthropist Rich deVos welcomes Dr. John Reed and the Burnham Institute for Medical Research at the team’s season opener in November with a $1,250,000 donation.

way to regulate insulin activity, glucose and lipid metabolism. The study shows how reducing TOR function could be clinically beneficial to counter

FLORIDA’S BLOOD CENTERS

insulin resistance, metabolic syndrome and diabetes.

PROVIDES TEMPORARY HOME

Oldham’s findings appear in the journal Cell

Metabolism. Dr. Oldham, a Fishman Fund recipient,

FOR BURNHAM RESEARCH

acknowledged the Fund’s support of this project.

Florida’s Blood Centers, the state’s largest blood bank, has donated 14,000 square-feet of space to be remodeled into temporary laboratory space that will accommodate up to 40 Burnham scientists and supporting staff. The Institute will occupy most of the top floor of Florida’s Blood Centers headquarters in Orlando, allowing Burnham to progress with its research operation while construction is underway on the new facility at Lake Nona.

PHILANTHROPY MATTERS

A Message from

Blair Blum

Hearts drive passion, and I can think of no prouder demonstration than the 34 members of

Team Burnham who kicked off the New Year at P.F. Chang’s Rock n’ Roll Marathon and Half Marathon in Phoenix, Arizona. To earn a spot on the team, runners were asked to commit to six months of training and raise funds for Burnham. Hundreds of donations allowed Team Burnham to collectively Dear Burnham Supporters:

raise over $120,000 for medical research – good for their heart and good for our work. Team Burnham

Did you know that February

brought in donations from 11 countries including

is designated National Heart

Austria, Canada, Japan, Luxembourg, Netherlands,

Month? We’re reminded to have

Philippines, Portugal, Spain, Sweden and the United

our blood pressure and cholesterol

Kingdom. We welcome them to our global family

re-checked, eat a balanced diet

of supporters and are grateful for their interest in

and participate in a rigorous

the work of our scientists. You can read more about

exercise program to protect our

Team Burnham on page 10.

hearts.

I agree with all of the above,

As we look ahead, we see you in our future; we see you continuing to give from your heart to our work,

but I also think about the “heart” of the Burnham

and in support of Burnham. We need you! From

Institute for Medical Research. You are our heart

the bottom of our hearts, we thank you for your

– our loyal supporters. Your gifts allow our talented

continued support of our medical research.

scientists to pursue new and innovative avenues to cure today’s most heart-breaking diseases like Alzheimer’s, Parkinson’s and cancer.

Your continued support impacts our research and programs and you are also our greatest ambassadors in the community. Please continue to tell friends and family about the exciting research you’re reading about in the Burnham

www.burnham.org

Report and hearing about our community lectures.

Because you continue to believe in our work, we have more than doubled our donor base in less than six months. Thank you! We have listed our recent donors on page 13.

Sincerely, Blair Blum Sr. Vice President, External Relations bblum@burnham.org

The Legacy Society Profile of a Donor: Eugene “Ernest” Chipman

Chemical Engineering. Shortly after graduation, he was hired by Dupont and married his college sweetheart, Mary Louise. Together they had two children, Stephen and Margaret Anne.

By 1950, Ernest had established his own chemical manufacturing company, Productol, which he led until retiring in 1979.

E

ugene “Ernest” Chipman, a former trustee and valued friend of the Burnham Institute

for Medical Research, recently passed away at age 90. In the words of co-founder Lillian Fishman, “Ernest was a wonderful person and a brilliant financial mind. He will be missed.”

Ernest served on the Board of Trustees from

1990 until 1996. He was a dedicated member of the finance committee and thanks to his shrewd investment advice, an endowment fund was established to secure the future of the organization. Although he has passed, his passion for eradicating diseases will live on because Ernest left a bequest in his will to endow the “Chipman Research Fund” in perpetuity.

But in 1959, Ernest lost Mary Louise to cancer. She was only 44.

Ernest eventually remarried June Brasted Chipman. They shared 47 years of marriage and enjoyed a variety of activities including competitive sailing, tennis and filmmaking.

Upon retiring, Ernest and June moved to La Jolla, where he discovered the Burnham Institute

for Medical Research. The untimely

The untimely death of Ernest’s first wife had a profound impact on his future philanthropic giving.

death of his first wife, Mary Louise, had a profound impact on his life and shaped his future philanthropic giving: to find a cure for cancer.

Through his generous estate gift, his legacy will live

“ Ernest was a wonderful person

on at the Institute.

and a brilliant financial mind.

He will be missed.”

Please contact Patty Fuller at pfuller@burnham.org or (858) 795-5231 for more information about adding the Burnham Institute for Medical Research to your will.

Ernest’s life epitomized the American Dream. young age to become an engineer. He graduated from Purdue University in 1937 with a degree in

www.burnham.org

Growing up on a farm, Ernest set his sights at a

PHILANTHROPY MATTERS

T eam Burnham

major national running events, Team Burnham was the largest first-year traveling charitable team ever

Races in Phoenix

assembled for such an endeavor.

Rock n’ Roll Marathon

Burnham was inspirational,” said John C. Reed,

“The dedication and perseverance of Team

Runners raise community awareness and funds for Burnham Institute for Medical Research

M.D., Ph.D., President and CEO of the Burnham

Institute for Medical Research and a veteran marathon runner. “The team raised much-needed funds and created greater public awareness for

Burnham and our current research.”

The team was comprised of some of the Institute’s scientific leadership, as well as friends of the

T

organization from San Diego, Phoenix and across

eam Burnham for Medical Research joined

the country. The majority of Team Burnham’s

more than 37,000 racers in P.F. Chang’s

runners had never completed a full marathon.

“I remember the intense feelings and thoughts

Rock n’ Roll Marathon and Half Marathon in Phoenix, Arizona on Sunday, January 14 to raise awareness and funds for research

Research. “The uncomfortable euphoria at the

for Medical Research.

start, the fear of getting weaker in the middle of the course, suffering during the last miles, and the

unusual below-freezing temperatures

indescribable feeling of crossing the finish line.

at the starting line before running

Completing the marathon with Team Burnham was

through the streets and freeways of

an unforgettable experience.”

Prior to the race, members of Team Burnham

Phoenix, Scottsdale and Tempe.

completed a grueling six-month training program

Cheering

along with weekly group runs and/or walks with fans and over 60 live bands set the tempo for the race

www.burnham.org

with music ranging

10

Associate Professor, Burnham Institute for Medical

underway at the Burnham Institute Racers experienced

Dr. Reed ran a respectable 3:49 at the Rock n’ Roll Marathon.

at each mile,” said Maurizio Pellechia, Ph.D.,

trainers from West Coast Road Runners. While training, each member was asked to raise a minimum of $3,000 to support the innovative research efforts underway at the Institute. To date, the team has raised over $120,000 from over 700 individual gifts from 33 states and 11 countries

from reggae and jazz to

as well as corporate sponsors San Diego Gas &

country and rock.

Electric (SDG&E) and Bernstein Global Wealth

According to Elite

Management. The funds will be used largely to

Racing, the race organizer

support young Ph.D. researchers who work in

of P.F. Chang’s Rock n’

the laboratories performing the experiments that

Roll Marathon and other

ultimately save lives.

The team has raised over $120,000 from individual gifts from 11 countries as well as corporate sponsors SDG&E and Hunter Reed declares victory at the finish line of the Half Marathon.

Bernstein Global Wealth Management.

Please join us next year at the 2008 Rock n’ Roll Marathon in Phoenix, Arizona. Visit www.burnham.org or contact Chris Lee at chrislee@burnham.org or (858) 795-5232 for more information.

Burnham’s Judy Wade and husband, Dave, stay warm after racing in freezing temperatures.

Team Burnham Stats Training Start Date: July 8, 2006 Total miles completed during training runs: 550 miles.

Collectively, the team logged 20,350 miles (that’s 28 times round-trip from San Diego to Phoenix, Arizona!)

Team Burnham member, Bruce Meyer, completes his first marathon with a great time of 3:35.

Total Runners / Walkers: 34 Male: 19 Female: 15 Burnham employees: 60% First time completing a marathon or half-marathon: 89%

13.1 miles - Top Half-Marathon Runners Dr. Robert Rickert – 1:43:53 Nicole DeBerg – 1:50:07 Hunter Reed – 1:57:24 The ladies of Burnham’s External Relations, Patty Fuller, Karen Overklift, Claire Hill and Jocelyn Wyndham, celebrate at the 26 mile marker.

www.burnham.org

26.2 Miles - Top Marathon Runners Bruce Meyer – 3:35:29 Dr. Maurizio Pellecchia – 3:41:01 Dr. John Reed – 3:49:42

11

PHILANTHROPY MATTERS

Making the Most of Your Assets

For example, you make a gift of $2 million to

Grantor Lead Trusts

A

support medical research. You choose to pay us 6 percent a year for a period of 20 years. You will receive an upfront charitable income tax deduction of $1,322,824.36, which is the present value of the total income payments to the Institute over the life of the trust. Each year, the trust will pay us

re you in a high-earning period where re-directing a portion of your income to

charity makes sense? Perhaps you’re facing a very high tax year and want a deduction, but don’t want

$120,000, which will have a tremendous impact on innovative research at the Institute.

The trust’s annual earnings (minus the distributions) are taxable to the donor. However,

to permanently part with a valuable asset.

if the amount of our income and the length of time

Why not consider a Grantor Lead Trust?

This creative plan allows you to transfer cash or other property into a trust that makes payments

we receive it is adjusted sufficiently, the upfront tax deduction can offset this subsequent tax.

to a charitable organization, like the Burnham

Institute for Medical Research, for a set period of time. You decide the time period and payout amount. At the end of the trust term, the assets are transferred back to you or your spouse, presumably at a time when your tax situation is more favorable.

www.burnham.org

Wish List

12

The Stem Cell Research Center is dedicated to studying human embryonic stem cells, remarkable cells with the potential to differentiate into a wide range of specialized cell types. Scientists in this laboratory are investigating ways of coaxing stem cells to become heart muscle, brain cells, and other cell types. These cells may be useful for testing new drugs, understanding human diseases, and as cellular therapies for degenerative disorders such as diabetes, heart disease, and Alzheimer’s.

For more information to support equipment needs in the Stem Cell Research Center, please contact Chris Lee at chrislee@burnham.org or (858) 795-5232.

We’re happy to assist you and your financial advisors to find the best model to fit your charitable and estate planning goals. Please contact Patty Fuller at pfuller@burnham.org or (858) 795-5231 for more information.

Biosafety tissue culture hood: For sterile culturing of stem cells

$8,000

Laminar flow hood: For sterile transfers of cultured stem cells

$4,000

Incubator: To maintain cultures of human stem cells

$9,000

Centrifuge: To prepare cell samples for analysis

$3,000

Microcentrifuge: To analyze DNA and RNA

$1,800

Microscope, binocular: For micro-dissection of cell cultures

$10,000

Tissue culture microscope: To examine and document cell cultures

$6,000

Thermocycler: For PCR analysis of DNA and RNA

$7,500

Micropipettor To measure small volumes of solutions

$700

Micropipettor set: For dispensing reagents for biochemical analysis

$800

Water bath: To warm media used in human cell culture

$1,000

FIRST AND SECOND QUARTER DONATIONS Fiscal Year 2007 In the first and second quarters of Fiscal Year 2007 (July - December 2006), the Burnham Institute

for Medical Research in La Jolla received 1,028 generous contributions and pledges totaling $2,308,220.

The following lists individuals, foundations, corporations and organizations whose giving was $5,000 or more. We are grateful for these gifts that support our medical research.

Han and Ella Helders Loren Hinkelman Reena and Samuel Horowitz Alan Smith and Tiffany Hunter Brent and Joan Jacobs Irwin and Joan Jacobs Jeanne Jones and Don Breitenberg Peggy Jones Gwen Laidlaw Robert and Winifred Lauer Sheila and Jeffrey Lipinsky Jon Liss Jo Bobbi MacConnell and Guy Showley Ken and Mollie McCain Howard and Barbara Milstein Jim and Susan Morris Nico and Caroline Nierenberg Yvonne and Roy Polatchek Mark Pulido and Donna Walker Nathalie and Ken Riis Bill and Janie Rohn Ivor and Colette Royston Tom and Linda Sansone Ken and Candie Satterlee Bob and Sheryl Scarano Jordanna Schutz Drew and Noni Senyei Aaron and Cynthia Shenkman Darlene Shiley Scott and Judy South Alan Stanford Stuart and Karen Tanz Molly Thornton

Andrew and Erna Viterbi Kristiina Vuori Martha Walker and John Reed Barbara and William Warren Armi and Al Williams Terrance Lee Zehrer FOUNDATIONS Gordon Ross Medical Foundation Hawaii Community Foundation J.W. Kieckhefer Foundation Legacy Endowment Legler Benbough Foundation Wattis Dumke Foundation CORPORATIONS / ORGANIZATIONS Althea Technologies, Inc. BIOCOM Chemicon International CONNECT DBC Construction General Atomics Illumina Invitrogen Merck Pfizer Serologicals Slough Estates USA, inc.

STARS (Science, Technology And Research Support) Stratagene UCSD

www.burnham.org

INDIVIDUALS Lisa and Steve Altman Rusti Bartell Molly and David Begent Laurence and Cindy Bloch Blair Blum and Jim Sexton Mary Bradley Arthur Brody and Phyllis Cohn Matthew Browar Denyse and Timothy Browne Terrance Bruggeman and Dianne Dyer-Bruggeman Esther Burnham John Burnham and Laurie Vanden Berg Malin and Roberta Burnham Howard and Toby Cohen Eric Dudl Robert and Barbara Dudl Karin and Gary Eastham Carlton J. Eibl and Amy Corton Anne Evans Kurt and Jennifer Eve Audrey Geisel and Alex Butterfield Ian and Gail Gill Alan and Marleigh Gleicher Manny Gleicher Deana and Morley Golden Carole and Howard Goldfeder Lynn Gorguze and Councilman Scott Peters Ginger and John Graham William D. and Mary Grant Bill and Kay Gurtin Bill Hanley

13

CALENDAR OF EVENTS March 20, 2007 – 12:00 – 1:30 p.m.

CONNECT Frontiers in Science and Technology Lecture Series

“Cheating Death: Novel Therapies for Controlling Cell Life and Death”

Dr. John C. Reed, President and CEO, Burnham Locaton: CONNECT For more information, please visit www.connect.org

March 22, 2007 – 8:00 a.m. – 5:00 p.m.

Burnham’s 29th Annual Symposium “In Vivo Molecular Imaging Frontiers” Location: Hilton Torrey Pines For information, please contact Nicholas Burchfield nburchfi@burnham.org or (858) 646-3100 x 3057

April 12, 2007 – 12:00 – 1:30 p.m.

CONNECT Frontiers in Science and Technology Lecture Series

“Cross-Talk Between Stem Cells and the Neurodegenerative Environment”

Dr. Evan Snyder, Professor and Program Director, Burnham Locaton: CONNECT For more information, please visit www.connect.org

November 17, 2007 Save the Date

Burnham Institute for Medical Research Gala The Grand Del Mar For more information, please contact Jocelyn Wyndham at jwyndham@burnham.org or (858) 795-5216

Nonprofit Organization U.S. Postage

PAID The Burnham Institute 10901 North Torrey Pines Road La Jolla, CA 92037 (858) 646-3100 www.burnham.org