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Global Cryotherapy and Cryosurgery Market (2014-2020)
By Type (Cryosurgery, Ice Pack Therapy and Cryogenic Chamber Therapy), By Technique (Spray, Forceps, Cryo Probe And Others); By Device (Cryogun, Probes, Cryogen And Others), By Application (Cancer Therapy and Skin Disease) and By Geography
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Table of Contents 1. Global Cryotherapy and Cryosurgery Market - Market Overview 2. Executive Summary 3. Global Cryotherapy and Cryosurgery Market - Market Landscape 3.1. Market Share Analysis 3.2. Comparative Analysis 3.2.1.
Product Benchmarking
3.2.2.
End user profiling
3.2.3.
Patent Analysis
3.2.4.
Top 5 Financials Analysis
4. Global Cryotherapy and Cryosurgery Market – Market Forces 4.1. Market Drivers 4.2. Market Constraints 4.3. Market Challenges 4.4. Attractiveness of the Global Cryotherapy and Cryosurgery Market 4.4.1.
Power of Suppliers
4.4.2.
Power of Customers
4.4.3.
Threat of New entrants
4.4.4.
Threat of Substitution
4.4.5.
Degree of Competition
5. Global Cryotherapy and Cryosurgery Market – Strategic Analysis 5.1. Value Chain Analysis 5.2. Pricing Analysis 5.3. Opportunities Analysis 5.4. Product/Market Life Cycle Analysis
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5.5. Suppliers and Distributors 6. Global Cryotherapy and Cryosurgery Market – By Type of Cryotherapy 6.1. Cryosurgery 6.2. Icepack therapy 6.3. Cryogenic chamber therapy 7. Global Cryotherapy and Cryosurgery Market - By Application Technique 7.1. Spray Technique 7.2. Dipstick applicator Type of Cryogen 7.3. Cryo probe 7.4. Thermo-couple device 7.5. Forceps Technique 7.6. Others 8. Global Cryotherapy and Cryosurgery Market - Cryosurgery By Type of cryogen 8.1. Liquid Nitrogen 8.2. Carbon dioxide 8.3. Argon 8.4. Dimethyl ether-propane 8.5. Others 9. Global Cryotherapy and Cryosurgery Market - By Disease Area Application 9.1. Introduction 9.2. Cancer Therapy 9.3. Cardiovascular Disease 9.4. Skin Disease 9.5. Gynaecological Disease 9.6. Other General Surgery
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10. Global Cryotherapy and Cryosurgery Market - By Major Device Types 10.1.
Introduction
10.2.
Cryogun/ Spray gun
10.3.
Gas Pressure Gauge
10.4.
Probes
10.5.
Cryogen
10.6.
Liquid Dewar/Gas Cylinder
10.7.
Others
11. Global Cryotherapy and Cryosurgery Market - Geographic Analysis 11.1.
Introduction
11.2.
North America 11.2.1. U.S. 11.2.2. Canada 11.2.3. Mexico
11.3.
Asia-Pacific 11.3.1. China 11.3.2. Japan 11.3.3. Singapore 11.3.4. Others
11.4.
Europe 11.4.1. Germany 11.4.2. U.K 11.4.3. France 11.4.4. Others
11.5.
ROW
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12. Global Cryotherapy and Cryosurgery Market- Market Entropy 12.1.
New Product Launches
12.2.
M&As, Collaborations, JVs and Partnership
13. Company Profiles (Overview, Financials, SWOT Analysis, Developments, Product Portfolio) 13.1.
Cryoalfa Europe
13.2.
CryoCOncepts LP
13.3.
Mectronic Medicale srl
13.4.
Wallach Surgical Devices
13.5.
Medtronic
13.6.
CryoProbe
13.7.
Cortex Technology
13.8.
Brymill Cryogenics Systems
13.9.
Erbe medical
13.10. Metrum Cryoflex 13.11. MedGyn 13.12. CoolTouch Inc. 13.13. Optikon 13.14. Uzumcu 13.15. SMT medical 13.16. Cryonic 13.17. Inomed 13.18. Zimmer Medizin Systeme 13.19. Gbo Medizintechnik AG 13.20. Physio med 13.21. HIRONIC
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14. Appendix 14.1.
Abbreviations
14.2.
Sources
14.3.
Research Type of Cryogen ology
14.4.
Bibliography
14.5.
Compilation of Expert Insights
14.6.
Disclaimer
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LIST OF TABLES Table 1 Global Cryotherapy and Cryosurgery, List of Companies Covered Table 2 Global Cryotherapy and Cryosurgery Market Competitive Share Analysis, 2013 (%) Table 3 Top 5 Market Players Financials Analysis Table 4 Global Cryotherapy and Cryosurgery Market Revenue, 2014 – 2020 ($M) Table 5 Global Cryotherapy and Cryosurgery Market Revenue, By Application technique, 2014 – 2020 ($M) Table 6 Global Cryotherapy and Cryosurgery Market Revenue, By Type of Cryotherapy, 2014 – 2020 ($M) Table 7 Global Cryotherapy and Cryosurgery Market Revenue, By Type of Cryogen, 2014 – 2020 ($M) Table 8 Global Cryotherapy and Cryosurgery Market Revenue, By Disease Area Application, 2014 – 2020 ($M) Table 9 Global Cryotherapy and Cryosurgery Market Revenue, By Major Device Type, 2014 – 2020 ($M) Table 10 Average Selling Price Analysis, Cryotherapy and Cryosurgery, 2014 – 2020 ($M) Table 11 Cryotherapy and Cryosurgery Market Revenue in Cancer Therapy, By Application Technique, 2014 – 2020 ($M) Table 11 Cryotherapy and Cryosurgery Market Revenue in Cancer Therapy, By Type of Cryogen, 2014 – 2020 ($M) Table 12 Cryotherapy and Cryosurgery Market Revenue in Cancer Therapy, By Major Device Type, 2014 – 2020 ($M) Table 13 Cryotherapy and Cryosurgery Market Revenue in Cardiovascular Diseases, By Application Technique, 2014 – 2020 ($M) Table 14 Cryotherapy and Cryosurgery Market Revenue in Cardiovascular Diseases, By Type of Cryogen, 2014 – 2020 ($M) Table 15 Cryotherapy and Cryosurgery Market Revenue in Cardiovascular Diseases, By Major Device Type, 2014 – 2020 ($M) Table 16 Cryotherapy and Cryosurgery Market Revenue in Skin Disease, By Application Technique, 2014 – 2020 ($M) Table 17 Cryotherapy and Cryosurgery Market Revenue in Skin Disease, By Type of Cryogen, 2014 – 2020 ($M) Table 18 Cryotherapy and Cryosurgery Market Revenue in Skin Disease, By Major Device Type, 2014 – 2020 ($M) Table 19 Cryotherapy and Cryosurgery Market Revenue in Gynaecological Disease, By Application Technique, 2014 – 2020 ($M))
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Table 20 Cryotherapy and Cryosurgery Market Revenue in Gynaecological Disease, By Type of Cryogen, 2014 – 2020 ($M) Table 21 Cryotherapy and Cryosurgery Market Revenue in Gynaecological Disease, By Major Device Type, 2014 – 2020 ($M) Table 22 Cryotherapy and Cryosurgery Market Revenue in Other General Surgery, By Type of Cryogen, 2014 – 2020 ($M) Table 23 Cryotherapy and Cryosurgery Market Revenue in Other General Surgery, By Application Technique, 2014 – 2020 ($M) Table 24 Cryotherapy and Cryosurgery Market Revenue in Other General Surgery, By Major Device Type, 2014 – 2020 ($M) Table 25 Cryotherapy and Cryosurgery Market Revenue in Cryogun/Spray gun, By Disease Area Application, 2014 – 2020 ($M) Table 26 Cryotherapy and Cryosurgery Market Revenue in Gas Pressure Gauge, By Disease Area Application, 2014 – 2020 ($M) Table 27 Cryotherapy and Cryosurgery Market Revenue in Probes, By Disease Area Application, 2014 – 2020 ($M) Table 28 Cryotherapy and Cryosurgery Market Revenue Cryogen, By Disease Area Application, 2014 – 2020 ($M) Table 29 Cryotherapy and Cryosurgery Market Revenue in Liquid Dewar/Gas Cylinder, By Disease Area Application, 2014 – 2020 ($M) Table 30 Cryotherapy and Cryosurgery Market Revenue in Others, By Disease Area Application, 2014 – 2020 ($M) Table 31 Cryotherapy and Cryosurgery Market Revenue in Cryogun/Spray gun, By Type of Cryogen, 2014 – 2020 ($M) Table 32 Cryotherapy and Cryosurgery Market Revenue in Gas Pressure Gauge, By Type of Cryogen, 2014 – 2020 ($M) Table 33 Cryotherapy and Cryosurgery Market Revenue in Probes, By Type of Cryogen, 2014 – 2020 ($M) Table 34 Cryotherapy and Cryosurgery Market Revenue Cryogen, By Type of Cryogen, 2014 – 2020 ($M) Table 35 Cryotherapy and Cryosurgery Market Revenue in Liquid Dewar/Gas Cylinder, By Type of Cryogen, 2014 – 2020 ($M) Table 36 Cryotherapy and Cryosurgery Market Revenue in Others, By Type of Cryogen, 2014 – 2020 ($M) Table 37 Cryotherapy and Cryosurgery Market Revenue in Cryogun/Spray gun, By Application Technique, 2014 – 2020 ($M) Table 38 Cryotherapy and Cryosurgery Market Revenue in Gas Pressure Gauge, By Application Technique, 2014 – 2020 ($M)
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Table 39 Cryotherapy and Cryosurgery Market Revenue in Probes, By Application Technique, 2014 – 2020 ($M) Table 40 Cryotherapy and Cryosurgery Market Revenue Cryogen, By Application Technique, 2014 – 2020 ($M) Table 41 Cryotherapy and Cryosurgery Market Revenue in Liquid Dewar/Gas Cylinder, By Application Technique, 2014 – 2020 ($M) Table 42 Cryotherapy and Cryosurgery Market Revenue in Others, By Application Technique, 2014 – 2020 ($M) Table 43 Cryotherapy and Cryosurgery Market Revenue in Liquid Nitrogen, By Application Technique, 2014 – 2020 ($M) Table 44 Cryotherapy and Cryosurgery Market Revenue in Carbon Dioxide, By Application Technique, 2014 – 2020 ($M) Table 45 Cryotherapy and Cryosurgery Market Revenue in Argon, By Application Technique, 2014 – 2020 ($M) Table 46 Cryotherapy and Cryosurgery Market Revenue in Dimethyl ether-propane By Application Technique, 2014 – 2020 ($M) Table 47 Cryotherapy and Cryosurgery Market Revenue in Others, By Application Technique, 2014 – 2020 ($M) Table 48 Cryotherapy and Cryosurgery Market Revenue in Liquid Nitrogen, By Disease Area Application, 2014 – 2020 ($M) Table 49 Cryotherapy and Cryosurgery Market Revenue in Carbon Dioxide, By Disease Area Application, 2014 – 2020 ($M) Table 50 Cryotherapy and Cryosurgery Market Revenue in Argon, By Disease Area Application, 2014 – 2020 ($M) Table 51 Cryotherapy and Cryosurgery Market Revenue in Dimethyl ether-propane, By Disease Area Application, 2014 – 2020 ($M) Table 52 Cryotherapy and Cryosurgery Market Revenue in Others, By Disease Area Application, 2014 – 2020 ($M) Table 53 Cryotherapy and Cryosurgery Market Revenue in Liquid Nitrogen, By Major Device Types, 2014 – 2020 ($M) Table 54 Cryotherapy and Cryosurgery Market Revenue in Carbon Dioxide, By Major Device Types, 2014 – 2020 ($M) Table 55 Cryotherapy and Cryosurgery Market Revenue in Argon, By Major Device Types, 2014 – 2020 ($M) Table 56 Cryotherapy and Cryosurgery Market Revenue in Dimethyl ether-propane, By Major Device Types, 2014 – 2020 ($M) Table 57 Cryotherapy and Cryosurgery Market Revenue in Others, By Major Device Types, 2014 – 2020 ($M)
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Table 58 Cryotherapy and Cryosurgery Market Revenue in Spray Technique, By Major Device Types, 2014 – 2020 ($M) Table 59 Cryotherapy and Cryosurgery Market Revenue in Dipstick applicator method, By Major Device Types, 2014 – 2020 ($M) Table 60 Cryotherapy and Cryosurgery Market Revenue in Cryo probe, By Major Device Types, 2014 – 2020 ($M) Table 61 Cryotherapy and Cryosurgery Market Revenue in Thermo-couple device, By Major Device Types, 2014 – 2020 ($M) Table 62 Cryotherapy and Cryosurgery Market Revenue in Forceps technique, By Major Device Types, 2014 – 2020 ($M) Table 63 Cryotherapy and Cryosurgery Market Revenue in Others, By Major Device Types, 2014 – 2020 ($M) Table 64 Cryotherapy and Cryosurgery Market Revenue in Spray Technique, By Disease Area Application, 2014 – 2020 ($M) Table 65 Cryotherapy and Cryosurgery Market Revenue in Dipstick applicator method, By Disease Area Application, 2014 – 2020 ($M) Table 66 Cryotherapy and Cryosurgery Market Revenue in Cryo probe, By Disease Area Application, 2014 – 2020 ($M) Table 67 Cryotherapy and Cryosurgery Market Revenue in Thermo-couple device By Disease Area Application, 2014 – 2020 ($M) Table 68 Cryotherapy and Cryosurgery Market Revenue in Forceps technique, By Disease Area Application2014 – 2020 ($M) Table 69 Cryotherapy and Cryosurgery Market Revenue in Others, By Disease Area Application, 2014 – 2020 ($M) Table 64 Cryotherapy and Cryosurgery Market Revenue in Spray Technique, By Type of Cryogen, 2014 – 2020 ($M) Table 65 Cryotherapy and Cryosurgery Market Revenue in Dipstick applicator method, By Type of Cryogen, 2014 – 2020 ($M) Table 66 Cryotherapy and Cryosurgery Market Revenue in Cryo probe, By Type of Cryogen, 2014 – 2020 ($M) Table 67 Cryotherapy and Cryosurgery Market Revenue in Thermo-couple device, By Type of Cryogen, 2014 – 2020 ($M) Table 68 Cryotherapy and Cryosurgery Market Revenue in Forceps technique, By Type of Cryogen, 2014 – 2020 ($M) Table 69 Cryotherapy and Cryosurgery Market Revenue in Others, By Type of Cryogen, 2014 – 2020 ($M) Table 70 Europe Cryotherapy and Cryosurgery Market Revenue, 2014 – 2020 ($M)
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Table 71 Asia-Pacific Cryotherapy and Cryosurgery Market Revenue, 2014 – 2020 ($M) Table 72 M&A, JV, Agreements, Cryotherapy and Cryosurgery Industry
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LIST OF FIGURES Figure 1 Segmentation of Cryotherapy and Cryosurgery Market, By Product Type Figure 2 Segmentation of Cryotherapy and Cryosurgery Market, By Type of Cryogen Figure 3 Segmentation of Cryotherapy and Cryosurgery Market, By Application Technique Figure 4 Segmentation of Cryotherapy and Cryosurgery Market, By Major Device Type Figure 5 Cryotherapy and Cryosurgery Market, List of Companies Covered Figure 6 Global Cryotherapy and Cryosurgery Market Competitive Share Analysis, 2014 (%) Figure 7 Global Cryotherapy and Cryosurgery Market Revenue, 2014 - 2020 ($bn) Figure 8 Average Selling Price Analysis of Cryotherapy and Cryosurgery, 2014 – 2020 ($) Figure 9 Global Cryotherapy and Cryosurgery Market Revenue, By Application Technique, 2014 (%) Figure10 Global Cryotherapy and Cryosurgery Market Revenue, By Type of Cryogen, 20142020 ($M) Figure11 Global Cryotherapy and Cryosurgery Market Revenue, By Major Device Type, 2014-2020 ($M) Figure12 Global Cryotherapy and Cryosurgery Market Revenue, By Geographic Region, 2014 – 2020 ($M)
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REPORT SCOPE The Global Cryotherapy and Cryosurgery Market has been segmented into different categories, based on application technique, cryogen used, disease area application and major device types. Each of these segments is further broken down into sub-segments give an indepth analysis of the market. The overall market is also presented from the perspective of different geographic regions and the key countries for this industry. Competitive landscape for each of the product types is highlighted and market players are profiled with attributes of company overview, financial overview, business strategies, product portfolio and recent developments. Market shares of the key players for 2012 are provided. The prominent players profiled in this report are Cryoalfa Europe Ltd, CryoConcepts LP, Mectronic Medicale S.R.L, Wallach Surgical Devices, Medtronic, CryoProbe, Cortex Technology and Brymill Cryogenics Systems. The report contains the most detailed and in-depth segmentation of the global Cryotherapy and Cryosurgery Market.
STAKEHOLDERS Following are the key stakeholders of this market: Product OEMs Contract manufacturers Service providers Component suppliers Health care professionals Health care companies
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EXECUTIVE SUMMARY Cryotherapy is the process of using low temperatures for medical therapy; this refers to all the procedures that are both destructive and non-destructive. Cryosurgery is a type of Cryotherapy, wherein deceased or abnormal tissues are destroyed using low temperatures, this is a destructive procedure performed using an openly surgical approach. This is used primarily to treat cancers such as retinoblastoma, basal cell and squamous cell carcinoma, prostate cancer and cervical cancer. Dermatologists have been using Cryotherapy for various purposes such as to treat skin tags, nodules, pre-cancerous skin moles etc., since the turn of the century. With the development of the vacuum flask to store sub-zero liquid elements, such as nitrogen, oxygen and hydrogen, the use of Cryotherapy increased exponentially. Being a minimally invasive procedure, Cryosurgery is preferred over open surgeries, thereby boosting the Cryosurgery market. Moreover, as the application is localized, healthy tissue is maintained. This minimises side effects for the healthy tissue. Cryosurgery is also a favourable solution, in case wherein an individual has to be subjected to multiple treatments. It can safely be used alongside other standard treatment options such as surgery, chemotherapy, hormone therapy and radiation. Furthermore, cryosurgery is a feasible option for candidates who are not suitable for conventional surgery due to their age or any other medical condition.
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SAMPLE TABLE: GLOBAL CRYOTHERAPY AND CRYOSURGERY, BY APPLICATION, 2014-2020 ($M) Application
2014
2015
2016
2017
2019
2020
Cancer Therapy
xx
xx
xx
xx
xx
xx
CAGR% (20152020) xx%
Cardiovascular Disease Skin Disease
xx
xx
xx
xx
xx
xx
xx%
xx
xx
xx
xx
xx
xx
xx%
Gynecological Disease Other General Surgery Total
xx
xx
xx
xx
xx
xx
xx%
xx
xx
xx
xx
xx
xx
xx%
xx
xx
xx
xx
xx
xx
xx%
Source: Industry ARC analysis.
The global Cryotherapy and Cryosurgery Market is estimated to grow at a CAGR of xx% during the forecast period 2014-2020, from $xx M in 2014 to reach $xx M by 2020.
SAMPLE TABLE: GLOBAL CRYOTHERAPY AND CRYOSURGERY MARKET REVENUE, BY REGION, 2014-2020 ($M) Region
2014
2015
2016
2017
2019
2020
North America APAC
xx
xx
xx
xx
xx
xx
CAGR% (20152020) xx%
xx
xx
xx
xx
xx
xx
xx%
Europe
xx
xx
xx
xx
xx
xx
xx%
ROW
xx
xx
xx
xx
xx
xx
xx%
Total
xx
xx
xx
xx
xx
xx
xx%
Source: Industry ARC analysis
This report focuses on the Cryotherapy and Cryosurgery market opportunities and growth prospects. The market has been segmented by geography as North America, Europe, AsiaPacific, and Rest of the World (RoW). Out of these regions, North America and Europe are the regions that account for the majority of market share in the global Cryosurgery market. Some of the major factors driving the demand in these regions are well-developed healthcare
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sector that is equipped with latest technologies, trained healthcare professionals, and evergrowing disposable income together with favourable reimbursement policies. With rapid development in the economies of Asia-Pacific region, healthcare sector is projected to become more sophisticated which will lead to an increased demand in the Cryotherapy and Cryosurgery market. Market size and forecast are provided for each of these regions. A detailed qualitative analysis of the factors responsible for driving and restraining growth of the Cryotherapy and Cryosurgery market and future opportunities are provided in the report. This report on the Global Cryotherapy and Cryosurgery Market identifies many such insights and M&A opportunities, besides providing a detailed analysis of the Cryotherapy and Cryosurgery market.
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3. GLOBAL CRYOTHERAPY AND CRYOSURGERY MARKETMARKET LANDSCAPE 3.1 MARKET SHARE ANALYSIS Market share of all the major players of Cryotherapy and Cryosurgery market are analysed in this section.
SAMPLE TABLE: GLOBAL CRYOTHERAPY AND CRYOSURGERY MARKET, COMPETITIVE SHARE ANALYSIS, 2013 (%) Company Brymill Cryogenics Systems Cryoalfa Europe Ltd. CryoCOncepts LP Mectronic Medicale srl Wallach Surgical Devices Others
Market Share (%) xx% xx% xx% xx% xx% XX%
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KEY MARKET INSIGHTS According to the World Cancer Report 2014, published by the World Health Organization (WHO), approximately 14 million new cancer cases were reported in 2012 and this number is expected to increase to 22 million per year in the next 20 years Cancer mortality is estimated to increase from around 8.2 million per year to 13 million per year over the same period, thus increasing the global cancer burden by 70 % Incidence rates remain highest in the developed nations but mortality is relatively higher in developing nations due to lack of early detection and limited access to healthcare Cryosurgery is less invasive compared to other cancer treatment options, thereby minimizing surgical complications such as pain and bleeding Cryosurgery requires shorter hospital stays; for instance, in the case of prostate cancer, according to HCFA (Health Care Financing Administration), the cost of prostate cancer cryosurgery is approximately $13,500 as compared to that of $14,200 for brachytherapy and$15,000 for external beam radiation According to the recent study, the combination of intralesional cryosurgery with topical silicone gel sheeting is useful in the treatment of refractory keloids
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RESEARCH METHODOLOGY The quantitative and qualitative data collected for the Cryotherapy and Cryosurgery market report is from a combination of secondary and primary sources. Research interviews were conducted with senior executives and/or managers of leading Cryotherapy and Cryosurgery solution providers. These Key Opinion Leaders (KOLs) were then provided a questionnaire to gather quantitative and qualitative inputs on their operations, performance, strategies and views on the overall market, including key developments and technology trends. Data from interviews is consolidated, checked for consistency and accuracy, and the final market numbers are again validated by experts. The global market was split by products, disease area and geography based on different factors like primary and secondary sources, understanding of the number of companies operating in each segment and also KOL insights. We have used various secondary sources such as directories, articles, white papers, newsletters, annual reports and paid databases such as OneSource, Hoovers and Factiva to identify and collect information for extensive technical and commercial study of the Cryotherapy and Cryosurgery market. The key players in the market and its value chain were identified through secondary research and their market opinions were also gathered in a similar way through telephonic interviews and questionnaires. We have also studied the annual reports of these top market players. Interviews with key opinion leaders such as directors, managers, marketing personnel were used extensively in understanding the need and emergence of Cryotherapy and Cryosurgery market.
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THE ARC ADVANTAGE An analytical model lies at the core of our process, ensuring logical consistency throughout our research. We complement the model with secondary data and interviews with industry experts to reflect the latest trends. With our final expert validation, we provide you with only the most accurate and actionable intelligence.
THE ARC PROCESS Analytical Method 1. Granular breakdown of drivers into factors 2. Validate all factors in terms of their present impact on the market 3. Assign weights to these factors in terms of their relevance and impact on the market 4. Build the Analytical Model ANALYTICAL MODEL
Base Method
1. Get a topdown estimate of the market 2. Follow it up with a bottom-up estimate of the market 3. Check forconsistency and new growth factors that are relevant over the next 10 Years
4. Build the Base model BASE MODEL
Consolidation Method 1. Granular breakdown of drivers into factors 2. Validate all factors in terms of their present impact on the market. 3. Assign weights to these factors in terms of their relevance and impact on the market. 4. Build the Consolidated Model
Delphi Verification 1. Verify the findings of the model with experts from across the value chain 2. Verify the findings with players across small and large enterprises 3. Tweak the model and add new factors 4. Finalize the ARC Model
CONSOLIDATED MODEL
ARC MODEL
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