Adopt cutting edge approaches in
Phenotypic Drug Discovery
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Will your screening assay system translate to clinics ? Introducing...
OncoPrime
TM
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What can be a better model than diseased cells... When that's what we intend to treat ! Highly complex
Simple
OncoPrime
TM
Cell lines with aberrant mutations not found in primary tumor
Organotypic, 3D cell culture Spheroid, Monolayers & Co-culture
Target based assays ignore the big picture
Diseased cells from patient samples
Early
>30
passage
passages
More clinically relevant
Less physiological
Do you really know what cells you are working with ? Recent studies suggest that only 40% of established cell lines are useful for drug discovery. Historically most drugs were discovered by phenotypic screens only Primary cell based phenotypic screening is the way to go...
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SAARUM SCIENCES Phenotypic Platforms for Drug & Biomarker Discovery
Screen new chemical or biological entities for optimal efficacy
Required R&D programmes and resources (US$)
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We Offer Comprehensive Drug Discovery Services...
Systematically screen cancers prevalent in India against a 'pill box' Repurpose drugs / combinations to derive novel IP and get to market faster Investigate unique tumor characteristics of Indian patients by gene profiling
Impact of
TM
OncoPrime
80
60
40
20
0
Target identification and selection
Generate patient response data by combining in vitro assays with clinical outcomes
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100
HTS
Disease Lead Preclinical relevant optimization and biological in Phase I hit in vitro studies clinical trials
Phase II studies
Phase III One studies approved drug
Phenotypic drug discovery using patient derived samples
We have a wide range of technology platforms available... Saarum Sciences Capabilities
Multicolor Flow cytometry Fluorescent microscopy Confocal microscopy FACS cell sorting Magnetic beads
Biacore CD HPLC GCMS LC-MALDI-TOF X-Ray diffraction
1
Sterile fresh cancer tissues are obtained at the biobank after EC approvals and informed consent
2
Explants or Primary Cells are derived from the tissues to obtain a heterogeneous culture
4
3
SNP genotyping / SNP arrays Next Generation Sequencing Bioinformatics Pathway / Network Systems biology
Cells are characterized for required parameters including complete pathology reports and used for desired assay(s)
Customized Primary Cell Phenotypic Assays with complete OMICs data ready for research
FISH IHC IHC-Fr ELISA Karyotyping
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OncoPrime can be used in multitude of ways... TM
Central Nervous System
Primary cell phenotypic screening assays for phenotypic drug discovery (PDD)
Respiratory System
Disease modeling & MoA studies using normal and diseased primary cells, CSCs/CTCs, hESCs/iPSCs etc Novel disease models engineered from primary cells (EMT/MET - available; others in pipeline)
Brain - Malignant Brain Malignant Breast - Malignant Breast - Malignant
Thyroid Thyroid Immunology
Breast Normal
Hematology
Toxicology assessment using hESCs and hiPSCs
Colon Colon Uterus - Normal Uterus - Normal
Fresh tissues available across variety of indications & pathologies; Oncology, CNS, CVS, hematology, immunology, dermatology etc
Prostate
Gastrointestinal System
FFPE tissue collection for retrospective studies e.g. disease recurrence
Prostate Genitourinary System
Overview of fresh tissue collection @ 1 site / 1 yr
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Use our platforms to accelerate your drug discovery pipeline... The cells are well characterized including morphology, cell surface markers and mutation profile Functional assays like migration, invasion, sphere forming assays etc. can be performed Your molecules could be screened across these phenotypes for target discovery, MOA eludication or in vitro effcacy asessment or drug repurposing or indication selection
OncoPrime
TM
Versatile phenotypes on offer
EMT & MET
Radiation resistant tumor cells
Cancer Stem cells
Tumor Milieu - with CAFs - with Immune cells - Tumor explants
Chemoresistant tumor cells
Radiation sensitive tumor cells
In vitro phenotypic assays Derivation of cell lines, engineered platforms Generation of tissue arrays, gene, protein arrays Generation of mouse & zebrafish xenografts
Novel Biomarker Targets
Identify resistance mechanisms
Fast track your drug development process with
Primary Cell Based Phenotypic Assays
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Advantages of using OncoPrime
TM
Primary cell panels derived from patient samples for various tumor types Short term cultures retaining clinically relevant features of the disease including tissue heterogeneity, proliferation rate and gene expression profiles Address clinical variability such as different disease stages spanning from pre-cancerous, benign lesions to metastatic cancer Well characterized for driver mutations relevant to patient population
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Associated medical records (EMR) of the patient for additional information
Why choose Saarum Sciences... Saarum Sciences is an innovative biotech company developing & employing novel primary cell based platforms for phenotypic drug & biomarker discovery applications We have several decades of proven global drug discovery and cell biology expertise across all major therapeutic areas Ongoing collaborations with a wide variety of clientele such as scientific organizations, pharmaceutical & biotech sector, research institutes and CROs Saarum has a steady inflow of freshly procured & well-annotated patient-derived primary samples through its sister concern Sapien Biosciences Sapien Biosciences, in partnership with Apollo Hospitals (India's largest healthcare provider), has set up India's largest state-of-the-art bio-repository that is systematically acquiring & archiving patient samples under appropriate ethical consent & regulatory approvals
Request for information:
Saarum Sciences Pvt. Ltd., 1st Floor, AIMSR Building, Apollo Health City, Jubilee Hills, Hyderabad 500096, India. Tel: +91-9704600283, +91-40-20084362 Email: info@saarum.com Website: http://www.saarum.com
SAARUM SCIENCES Phenotypic Platforms for Drug & Biomarker Discovery