SHLS12 IN COMBINATION WITH METAL
A material with unique viscoelastic properties A Three dimensional matrix made of polysaccharide
what
how Silver ions present in SHLS12 exert activity against GRAM+ e GRAM– bacteria antibiotic resistant. The affinity between the components create a 3D network with strong viscoelastic properties. The rheological profile and the antimicrobial activity are the key factors for a broad range of applications as medical devices with barrier effect against bacteria and reduction of biofilm growth. The chemical affinity of the components and their balance brings to products with tailored characteristics, improving the possible applications.
THE SAME PATH BUT DIFFERENT RESULTS
SAME EFFICENCY
ACTIVITY ON BACTERIAL BIOFILM
CLINICAL STUDIES & TESTS
1
ACTIVITY AGAINST GRAM+ AND GRAM- BACTERIA O.D. 620
Activity against STREPTOCOCCUS AUREUS
0,8 0,6 0,4 0,2 0
SHLS12 (0.1%)
SHLS12 (0.05%)
SHLS12 (0.01%)
Control
No bacterial growth is observed already at very low concentration after 4 h from the addition of SHLS on preformed biofilm. SHLS12 (0.2%)
CITOTOXICITY
Control
Activity against PSEUDOMONAS AUREUGINOSA
Measures of cytotoxicity of BALB 3T3 of different solutions show the complete absence of cytotoxicity even at concentrations higher than those active against bacteria and biofilm growth
SHLS12 (0.1%)
Negative control
Positive Control (0.1%)
SHLS12 (0.4%)
Negative control
Positive Control (0,4%)
CONCLUSIONS SHLS12 (0.2%)
Control
The silver ions act against a broad range of bacteria reducing the growth rate. Retaining its activity over time.
Biological Active Silver Ions in SHLS12 is the key point in the formation of a 3D matrix with barrier activity against differents strains of bacteria and on biofilm growth without affecting on cells.
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