Laser treatment claims to turn brown eyes blue A clinic in California is testing a laser procedure that eliminates pigment in the patient's eyes, turning them blue. by Michelle Starr
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Ever been stymied in a desire to bat your baby blues by the fact that your eyes aren't actually blue? An experimental new procedure could see you permanently change your peepers' hue. StrĹ?ma Medical Corporation, based out of Laguna Beach, California, claims to have invented a new laser eye surgery technique that eliminates the pigment from the patient's eye. Here's how it works. In darker, warm eye colours -- browns and black -- the upper layer of the iris (the stroma) contains high concentrations of melanin, the natural pigment that effects skin colour, hair colour and eye colour. RELATED ARTICLES Bionic eye: 3D printing merges contact lens and
However, in blue and green eyes, the stroma contains very little melanin -- the blue colour is caused by a light-scattering effect called the Tyndall effect, similar to the Rayleigh scattering converted by Web2PDFConvert.com
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effect that makes the sky appear blue. Bluecoloured eyes are actually eyes without pigment. Strōma's technique uses a laser to disrupt the melanin in the stroma of the iris. The patient watches a small animation about a foot from their face, their head stabilised, while the laser does its work, a process that takes, in all, around 30 seconds per eye.
This causes the body to begin its own natural process of eliminating the pigment from the eye over several weeks following the treatment. The result? Sky blue eyes -- or so the company claims. The procedure is not yet available to the public. "We have completed a preliminary human study to test the safety and efficacy of the procedure and using what we've learned to design and build our next-generation device. Our next steps will be to complete our pilot and pivotal human clinical studies using our new device," the Strōma website reads. "Our plan is to treat about 20 patients in our initial pilot clinical study. Following the successful completion of that pilot study we will treat about 100 patients in multiple countries and follow them for a predetermined length of time." Only when governmental regulatory bodies are comfortable that the process is safe will the company start taking patients, at a price tag of around $5,000 -- and, of course, the team expects that the procedure will be available outside the US first, due to the cost and stringent regulations of obtaining approval. The team is also careful to note that it has worked hard to make sure pigmentary glaucoma -- whereby pieces of pigment from the iris are carried into the anterior chamber, causing pressure inside the eye and, if untreated, glaucoma -- does not result from its treatment.
"Some physicians on blogs and elsewhere have suggested that the Strōma procedure could cause pigmentary glaucoma," the team said. "We were concerned about this issue right from the start, so it was the first issue we tested and measured in our initial pre-clinical and clinical studies. Thus far, pigmentary glaucoma has not proved to be a problem in our pre-clinical or clinical studies." This is because the iris has a second layer of pigment -- the epithelium, located behind the iris. Pigmentary glaucoma occurs when pigment abrades off this back layer of the iris. Because the Strōma treatment only effects the upper layer of pigment -- the stroma -- and because it is removed via a laser-initiated process rather than abrasion -- the team believes that it won't pose a glaucoma risk. What is less clear is whether the laser itself is safe. The Q-Switched Nd:YAG infrared laser is often used for treating skin pigmentation; but Q-switched pulses are relatively long, which means there may be enough time for heat transfer into the iris, which could in turn cause damage. We have contacted Strōma about this issue and will update when we receive a reply. Another thing to take into account is that blue eyes have a higher prevalence of age-related macular degeneration, due to the lack of protective melanin -- so if you have darker eyes, you have a very good reason to hang onto them. The company is currently seeking patients for the clinical trials in Costa Rica, converted by Web2PDFConvert.com
Mexico, the Philippines, London, Paris, Toronto and Argentina. You can find out more and sign up on the Strōma website. Tags: Crave, Tech Culture ABOUT THE AUTHOR
Michelle Starr
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Nike's "Just do it" slogan is based on a murderer's last words, says Dan Wieden 14 March 2015 | 13 comments
Design Indaba 2015: the advertising executive behind Nike's "Just do it" slogan has told Dezeen how he based one of the world's most recognisable taglines on the words of a convict facing a firing squad (+ interview). Dan Wieden, co-founder of advertising agency Wieden+Kennedy, described the surprising genesis of the slogan in an interview at the Design Indaba conference in Cape Town last month. Related story: Marc Newson helped trigger a "manufacturing revolution" at Nike, says CEO Mark Parker "I was recalling a man in Portland," Wieden told Dezeen, remembering how in 1988 he was struggling to come up with a line that would tie together a number of different TV commercials the fledgling agency had created for the sportswear brand. "He grew up in Portland, and ran around doing criminal acts in the country, and was in Utah where he murdered a man and a woman, and was sent to jail and put before a firing squad." Wieden continued: "They asked him if he had any final thoughts and he said: 'Let's do it'. I didn't like 'Let’s do it' so I just changed it to 'Just do it'." The murderer was Gary Gilmore, who had grown up in Portland, Oregan – the city that is home to both Nike and Wieden+Kennedy. In 1976 Gilmore robbed and murdered two men in Utah and was executed by firing squad the following year (by some accounts Gilmore actually said "Let's do this" just before he was shot). converted by W eb2PDFConvert.com
Nike's first commercial featuring the "Just do it" slogan Nike co-founder Phil Knight, who was sceptical about the need for advertising, initially rejected the idea. "Phil Knight said, 'We don't need that shit'," Wieden said. "I said 'Just trust me on this one.' So they trusted me and it went big pretty quickly." The slogan, together with Nike's "Swoosh" logo, helped propel the sportswear brand into a global giant, overtaking then-rival Reebok, and is still in use almost three decades after it was coined. Campaign magazine described it as "arguably the best tagline of the 20th century," saying it "cut across age and class barriers, linked Nike with success – and made consumers believe they could be successful too just by wearing its products." The magazine continued: "Like all great taglines, it was both simple and memorable. It also suggested something more than its literal meaning, allowing people to interpret it as they wished and, in doing so, establish a personal connection with the brand."
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Dan Wieden
Born in 1945, Wieden formed Wieden+Kennedy in Portaland with co-founder David Kennedy in 1982. The company now has offices around the world and has "billings in excess of $3 billion," Wieden said. Wieden revealed in his lecture at Design Indaba that shares in the privately owned agency had recently been put into a trust, making it "impossible" for the firm to be sold. "I’ve sworn in private and in public that we will never, ever sell the agency," Wieden said. "It just isn’t fair that once sold, a handful of people will walk off with great gobs of money and those left behind will face salary cuts or be fired, and the culture will be destroyed." He added: "The partners and I got together a couple of years ago and put our shares in a trust, whose only obligation is to never ever, under no circumstances, sell the agency.” Here is an edited transcript of our interview with Dan Wieden: Marcus Fairs: You're probably bored to death of this question but tell me how the Nike slogan came about. converted by W eb2PDFConvert.com
Dan Wieden: So, it was the first television campaign we'd done with some money behind, so we actually came up with five different 30 second spots. The night before I got a little concerned because there were five different teams working, so there wasn't an overlying sensibility to them all. Some were funny, some were solemn. So I thought you know, we need a tagline to pull this stuff together, which we didn't really believe in at the time but I just felt it was going to be too fragmented. So I stayed up that night before and I think I wrote about four or five ideas. I narrowed it down to the last one, which was "Just do it". The reason I did that one was funny because I was recalling a man in Portland. He grew up in Portland, and ran around doing criminal acts in the country, and was in Utah where he murdered a man and a woman, and was sent to jail and put before a firing squad. And they asked him if he had any final thoughts and he said: "Let's do it". And for some reason I went: "Now damn. How do you do that? How do you ask for an ultimate challenge that you are probably going to lose, but you call it in?" So I thought, well, I didn't like "Let’s do it" so I just changed it to "Just do it". I showed it to some of the folks in the agency before we went to present to Nike and they said "We don't need that shit". I went to Nike and [Nike co-founder] Phil Knight said, "We don't need that shit". I said "Just trust me on this one." So they trusted me and it went big pretty quickly. Marcus Fairs: Most of Dezeen's audience is involved in making products, whether it's trainers or cars or whatever. What is the relationship between what you do and the product? Dan Wieden: Well if you notice in all the Nike work – I mean there is work that shows individual shoes, but a lot of the work that we do is more talking about the role of sports or athletics. And Nike became strong because it wasn't just trying to peddle products; it was trying to peddle ideas and the mental and physical options you can take. So it was really unusual and it worked very well. Marcus Fairs: And what about other clients? What do you do if the client just wants you to show the product? Dan Wieden: Well, it depends on the client as well. But you have to be adding something to a product that is beyond just taste, or fit, or any of that kind of stuff. You have to have a sensibility about the product, a sort of spirit of the product almost. Marcus Fairs: And do you turn down brands that have product which you don't think is good enough? Dan Wieden: Oh sure. And we fire clients!
Related story: Nike plans to launch Back to the Future shoes in 2015
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Disney Plans 'Frozen' Sequel Directors of the 2013 animated sensation, Jennifer Lee and Chris Buck, developing the follow up BY JON BLISTEIN March 12, 2015
Elsa, left, and Anna bond in 'Frozen.' ©Disney
When it comes to Frozen, Disney will not let it go: The company announced official plans for a sequel to the hit 2013 animated film during a shareholders meeting in San Francisco, Variety reports. While no release date was revealed, original directors Jennifer Lee and Chris Buck are developing the project for Walt Disney Ice Age 2014: Remembering the Year 'Frozen' Took Over » Animation Studios. While the film's legions of fans will have to wait for the official follow-up, a new short, Frozen Fever, can be seen before screenings of Disney's new live-action Cinderella, which open this weekend.
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"We enjoyed making Frozen Fever so much and being back in that world with those characters," said John Lasseter, chief creative officer of Walt Disney and Pixar Animation Studios. "Jennifer Lee and Chris Buck have come up with a great idea for a sequel and you will be hearing a lot more about it and we’re taking you back to Arendelle."
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Frozen was a monumental success for Disney, becoming the higest grossing animated film of all time, garnering nearly $1.3 billion at the box office, and winning Oscars for Best Animated Feature and Best Original Song, for "Let It Go." "Let It Go" — as sung by Elsa herself, Idina Menzel — and the Frozen soundtrack went on to become phenomenons in their own right as well. Menzel's rendition of the inspiring ballad peaked at Number Five on the Billboard Hot 100, while the soundtrack managed to secure the Number One spot on the Billboard 200 three separate times. It ended up becoming the highest selling album of 2014, moving nearly 3.5 million copies and handily besting LP's released by Beyoncé, Taylor Swift and One Direction.
Topics: Frozen A D V E R T I S E M E N T
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Word out of this year’s SXSW Interactive is that all anyone could talk about was Meerkat. If you weren’t in Austin last weekend, Meerkat is a new app that allows users to easily livestream video from their cellphones onto their Twitter accounts. Much like Twitter, and Foursquare before it, Meerkat’s big debut had everyone in Silicon Valley proclaiming it the next big thing converted by Web2PDFConvert.com
in social media. And the hype doesn’t seem to be overblown. The app has quickly racked up more than 100,000 downloads in just over two weeks. Another sign of the imminent rise of Meerkat is that Twitter decided to remove Meerkat from its social graph. So while Meerkat users can still broadcast live videos on their Twitter feeds, a user’s followers will no longer get a notification when a new live stream begins, making it harder to know when to tune in. This move came shortly after Twitter purchased a similar app, Periscope. But the social graph ban only increased Meerkat’s draw—who wouldn’t want to root for the little app that could? Why has the app infatuated so many? Because they see great potential in the ability to broadcast live video in real time. In the realm of news, the app opens up new avenues for user-generated journalism: no longer would viewers have to wait for cellphone videos to make their way online or on TV. BBC News has already “Meerkatted” (yes, that’s the term that’s caught on) this week’s Ferguson protests. In entertainment, Meerkat has already attracted a few highprofile names, including Jimmy Fallon, who streamed a monologue rehearsal, and Julia converted by Web2PDFConvert.com
Louis-Dreyfus, who used it at SXSW. While it’s too soon to call Meerkat the next Snapchat, it seems it’s only a matter of time before everyone is Meerkatting from the front row during Fashion Week.
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