Penn Vet by SteegeThomson Communications

LEADING THE PROFESSION. Making History.

Changing the Practice of Veterinary Medicine Animals sustain humankind in so many ways. They feed us, carry us, protect us, and accept our love and return it in full measure. Investing in their health and well-being is the least we can do. At Penn Vet, we have always been pioneers. We led the creation of the specialties of veterinary medicine and continue to enhance its practice. We do groundbreaking research that translates directly into clinical advances for humans as well as animals. We educate the veterinarians and researchers who will follow in our footsteps, inspiring those for whom the work is already more vocation than occupation. And we are beautifully integrated with that world-class biomedical research engine that is the University of Pennsylvania, where every type of research and medicine exist in a contiguous, collaborative space. Now we are focusing on our future once again. Making History: The Campaign for Penn Vet, a $125 million initiative, will hone our unparalleled advantages of people and place. We hope you will join us in changing the foundations and practice of veterinary medicine.

Promise. Passion. Purpose. Pride. Joan C. Hendricks, VMD, PhD The Gilbert S. Kahn Dean of Veterinary Medicine

Imagine a world where veterinarians can...

conquer cancer in dogs... cure laminitis...

stop avian flu...

We are closer than you think. Because at Penn Vet, we donâ&#x20AC;&#x2122;t keep the pace. WE SET IT.

Imagine a world where veterinarians can...

conquer cancer in dogs... cure laminitis...

stop avian flu...

We are closer than you think. Because at Penn Vet, we donâ&#x20AC;&#x2122;t keep the pace. WE SET IT.

We Care for All Creatures Great and Small. Clinical care is the capstone of Penn Vet, the place where education, research, and treatment come together. Our veterinarians make a difference each and every day in the lives and relationships of animals and their owners.

Penn Vet’s care is: Distinguished by diversity At the Matthew J. Ryan Veterinary Hospital in Philadelphia and the George D. Widener Hospital for Large Animals in Chester County, we serve animals and their owners from around the globe. Each year, we diagnose and treat more than 53,000 animals. This vast diversity in patients and practice prepares our students for the extraordinary.

Delivered by experts Our care teams take their direction from internationally renowned clinicians who apply the tools and techniques they often helped to invent. In routine veterinary care or life-threatening emergencies, in all disciplines of veterinary medicine across all species, we deliver the most up-to-date diagnoses and treatment available anywhere.

Fueled by discovery From stem cell research to studies that increase the chances of successful transplantation to clinical trials that test treatments for diseases like diabetes, Penn Vet’s research strength drives discovery, which in turn transforms care.

Enhanced by innovation We manage high-risk pregnancies in mares with a special telemetry unit that records fetal heart rates. We speed recovery from equine orthopedic surgery in a unique recovery pool developed by a Penn Vet surgeon. We have Pennsylvania’s only oncology and imaging facility dedicated to veterinary medicine. To uphold our standard of care, we build facilities to match our practitioners in caliber and scope.

Top-notch clinical services depend on inquisitive minds, compassionate hearts, and leading-edge facilities. We have the world’s finest clinicians. Making History: The Campaign for Penn Vet will ensure we provide them with tools and treatment facilities commensurate to their talents.

LEAVING A LEGACY OF HOPE When Kentucky Derby winner Barbaro shattered his hind leg at the Preakness in May 2006, owners GRETCHEN and ROY JACKSON had him brought to Penn Vet’s New Bolton Center. The world watched and waited. His right hind leg, fractured in three places, required five hours of intricate surgery. Months later, 80 percent of Barbaro’s left hind hoof was removed after laminitis developed, but the painful condition could not be halted. The Jacksons made the difficult decision to euthanize the champion in January 2007. His death, mourned by millions, prompted a surge of interest in laminitis, and the Jacksons endowed the Dean W. Richardson Chair for Equine Disease Research at Penn Vet. “There was never any question where Barbaro would go. We knew that New Bolton had the experience to make good diagnoses, the best equipment, and facilities. Everyone here displayed knowledge, capability, caring, and determination. Dean Richardson called us every day, usually around 6:30 a.m. He knew I woke up wondering if Barbaro had made it through the night. We felt the best way to honor the surgeon and the School was to endow a chair that would help find a solution for laminitis.”

SHARING THE GIFT OF COMPASSION When Rosie, JOHN and DEBORAH PIPER’s beloved Portuguese water dog, was diagnosed with lymphoma they were devastated. The Pipers began researching the best treatment options available and quickly discovered Penn Vet. To honor Rosie and the oncology team responsible for her compassionate treatment, the Pipers have created a residency research fund in oncology and plan to establish a scholarship during Penn’s capital campaign. Although Rosie did not win her battle with lymphoma, the Pipers hope their contribution will lead to new discoveries and treatment options for canine cancer. “Having Rosie was like adding another color to our world. As physicians, John and I didn’t always make our home life a priority. Rosie gave us a world outside of the hospital and brought balance and joy into our lives. She was so special and positively impacted everyone who met her. Through this research fund, Rosie will continue to touch people’s lives for a long time to come.”

We ask complex questions... and translate the answers into practice. Big breakthroughs such as the sequencing of the animal and human genomes open exciting new vistas of inquiry that will change potential into practice.

BASIC RESEARCH examines scientific questions at their most fundamental level. How does the immune system work? What molecular changes happen in a case of lymphoma or laminitis? RALPH BRINSTER, V’60, GR’64, the Richard King Mellon Professor of Reproductive Physiology, has set the pace and depth of Penn Vet’s leadership in fundamental research. His research on the properties and applications of stem cells and germ cells has established him as a founder of mammalian transgenesis — modifying the genome of mammals. His discoveries have dramatic implications for fertility and health in animals and humans. “Using stem cells that become germ cells, we have the potential to give children who become sterile as a result of early chemotherapy a real chance to restore their fertility as adults,” says Brinster. In addition to being a pioneer himself, he has mentored scientists who have become pioneers within Penn and across the globe. For his extraordinary contributions, Professor Brinster has received many prestigious awards, including France’s CharlesLéopold Mayer Prize and Israel’s Wolf Prize in Medicine.

TRANSLATIONAL RESEARCH transforms scientific discoveries into practical applications. It provides clinicians with new tools for treatment and diagnosis. When Kyra, an eight-year-old Rhodesian Ridgeback, was diagnosed with cancer she was expected to survive less than a year with standard chemotherapy. But enrollment in a state-of-the-art clinical trial using a novel canine cancer vaccine developed by Penn Vet and the Abramson Family Cancer Research Institute changed the odds. DR. NICOLA MASON, GR’04, Penn Vet’s Pamela Cole Professor in Companion Animal Medicine, and her colleagues Penn Medicine Assistant Professor Dr. Robert Vonderheide and Ryan Hospital Oncology Chief Dr. Karin Soremno, demonstrated that the vaccine could stimulate immune responses in the laboratory, then initiated a clinical trial to study the vaccine’s safety and efficacy in prolonging remission times in dogs with spontaneous-occuring lymphoma. Following vaccination, Kyra was cancer free for 25 months before her cancer returned — more than twice the life expectancy. “This is why I am at Penn,” says Mason, “it’s the place where ideas are born, tenable hypotheses are tested, and novel therapies result, which lead to medical advances in both human and veterinary medicine.”

CLINICAL RESEARCH examines the natural history of disease by first-hand interactions with patients. It provides relevant questions that basic research can address in depth, and it seeks to improve clinical practice. Chronic kidney disease — a progressive, irreversible condition — is a leading cause of death in cats. When the first feline kidney transplants were completed in 1987, only 71 percent of cats survived long enough to be discharged from the hospital. Today, Penn Vet’s DR. LILLIAN ARONSON, V’92, Renal Transplant Program founder and coordinator, has conducted more than 110 renal transplants on cats and, for the first time in June 2008, on a dog. Survival rates are dramatically higher; some cats live up to 10 years post-surgery. Dr. Aronson, whose patients come from around the world, is currently working to better identify risk factors for post-operative complications and develop immunosuppressive therapy to help avoid long-term complications including diabetes and infections. “Each surgery helps better define the essential elements for success. Each day, for each cat and dog, the future is brighter.”

Advancing knowledge in the complex world of medicine means we must change as quickly as technology does, add and equip laboratory space that can support innovation on two campuses, and attract minds capable of seeing ahead to the next question.

We educate and inspire the next generation of teachers and healers. “The education of veterinarians in the 21st century is a public health issue and a national imperative.” — Dr. Joan C. Hendricks, the Gilbert S. Kahn Dean of Veterinary Medicine

DRIVING INQUIRY A few hundred yards separate the Vernon and Shirley Hill Pavilion, Penn Vet’s newest, smartest learning space, from venerable Classroom A, through which every student since 1884 has passed. This short distance represents the whole of Penn Vet: the spirit of inquiry and possibility that drives us and the tradition and pride that ground us. MAINTAINING SINGULAR ADVANTAGES Within a great university research complex, Penn Vet enjoys a particularly close connection with Penn’s prestigious medical school. Fiercely committed to their students’ success, our faculty both teach and do. The region’s many biomedical companies and institutes and the school’s suburban/rural environment provide diverse opportunities for internships and service. Our curriculum offers choice among majors, tailored clinical rotations, and a VMD-PhD program that marries rigorous biomedical research training to clinical expertise.

Making History: The Campaign for Penn Vet will help us sustain that position by continuing to identify, admit, and support students who will become veterinarians one step ahead of the curve; recruit and retain faculty who will generate new knowledge; and build and maintain the facilities and tools that enhance learning in the 21st century. We are leaders in the competitive world of veterinary medical education. 8

NARAYAN AVADHANI, PHD

CATRINA KING, V’08, GR’12

CALEB MURPHY, V’10

As the Harriet Ellison Woodward Professor of Biochemistry, Dr. Narayan Avadhani is equal parts researcher and educator. His lab focuses on mitochondria, small structures within the cell that generate energy. Changes in mitochondria have been implicated in devastating diseases such as Alzheimer’s and cancer. Avadhani believes both his research and his teaching have benefited incalculably from the endowed chair he holds. “It gives you many things but the most important is flexibility. The endowment helps us to keep up the pace of our research regardless of the federal funding available. And it frees up time for teaching. At Penn Vet, basic researchers and clinical staff alike have a tremendous love of teaching; it is part of our legacy. We build excellent relationships with the students who are intelligent, inquisitive, and very eager to learn.”

Growing up in North Philadelphia, Catrina King knew she wanted to be a veterinarian, but the road ahead was untested. No one in Catrina’s family had ever gone to college, and money for education wasn’t readily available. Still, her parents always encouraged her. Catrina attended Philadelphia’s W. B. Saul High School of Agricultural Sciences and then received her bachelor’s degree in animal science from Penn State University. Her driving intellectual curiosity led her to pursue a joint VMD-PhD degree, and a Pfizer Animal Health scholarship helped make it possible. “You can’t put a price on what you learn in a joint doctorate program at a place like Penn. With the Vet and Medical schools so close together, you work constantly with people trained in different ways. The value goes beyond dollars.” Catrina is currently researching therapies and strategies for detecting colon cancer in both animals and humans. “Veterinarians make real contributions to public health,” she says, “and the research benefits us all.”

Caleb Murphy watched his father — now a prosperous and successful New York dairy farmer — weather hard times. “For a while we were one of those struggling small farm families, but we figured out how to maximize production and herd health — particularly nutrition. My father talked a great deal about the importance of his veterinarian at every stage.” Murphy, who started his academic career in pre-med, made his way to Penn Vet in a journey he wishes more people from the farm could take. “The deficit of veterinarians in rural communities comes not from a lack of interest, but rather of opportunity. The young people interested in animals often bypass medicine completely, not seeing it as available to them. They see doctors as individuals who had a step up in life and don’t realize there might be financial aid to help with the expense. And once you get here, Penn does so much to help you succeed.”

NARAYAN AVADHANI, PHD

CATRINA KING, V’08, GR’12

CALEB MURPHY, V’10

We stay the spread of disease, safeguard the food supply, and enhance economic development. Penn Vet’s research and superb clinical care prevent disease from starting and spreading and make a significant impact on Pennsylvania’s physical — and fiscal — well-being. SUSTAINABLE AND LOCAL AGRICULTURE What could be more essential than ensuring a supply of safe, affordable food? Pennsylvania’s farms are a rich source of nutrition for the nation and a critical economic asset for the Commonwealth. At New Bolton Center, our own cattle and swine herds help us investigate ways to improve animal health and increase productivity. Then we take what we have learned directly to the field, making more than 19,000 visits to local farms each year.

A LOWER RISK OF INFECTIOUS DISEASE From West Nile virus to avian flu, infectious diseases travel swiftly, leaving panic and devastation in their wake. Nearly 60 percent of all new infectious diseases of humans come from animals. With a robust research agenda and programs for assessment and control, Penn Vet is on the front lines of prevention. In the last two outbreaks of avian flu alone, a state-funded surveillance system averted nearly $5 billion in damages. HUMANE, VIGOROUS EQUINE INDUSTRY Magnificent and endlessly fascinating, horses have always forged partnerships with humans that are as practical as they are intuitive. Through therapeutic riding, farming, and competitive sport, Pennsylvania’s 250,000 horses — the fourth-largest equine population in the nation — help, heal, and excite. Penn Vet has helped the Commonwealth’s Racing Commission develop a premiere toxicology laboratory, and our unparalleled expertise in reproductive, diagnostic, and clinical services benefits owners and breeders throughout the country.

PROTECTING EARTH’S FRAGILE BIODIVERSITY Overfishing, overbuilding, risk of infection, and poor nutrition are just a few of the factors that increasingly threaten natural habitats. Our veterinarians work with conservationists to develop successful wildlife management programs, while researchers help minimize human exposure to wildlife pathogens. To support aquaculture, the fastest growing sector of the nation’s animal industry, our Aquavet® program trains vets in aquatic veterinary medicine. Public health and economic development are critical to quality of life in any century. Recognizing that Penn Vet is on the front line of both, the Commonwealth recently invested $17 million in facilities and programs to help us prevent and detect disease. Making History: The Campaign for Penn Vet can leverage those efforts by supporting research, facilities, and tools that are both portable and effective. Our lives — and our livelihoods — depend on it.

At a Time of Unprecedented Need…

Penn Vet is Prepared to Lead. WE HAVE A CLEAR VISION FOR THE FUTURE. We will increase the size of our incoming classes in both the VMD and VMD-PhD programs to help alleviate national shortages.

THE WORLD FACES SERIOUS SHORTAGES OF ALL TYPES OF VETERINARIANS. The high costs of education mean fewer professionals can enter large animal medicine and public health. The global nature of the 21st century speeds the spread of disease among species, while increasing resistance to antibiotics weakens our defenses against it. Bio-security threats are real and escalating, requiring a heightened level of knowledge and vigilance. Rising costs make local, safe, and sustainable food sources a top priority.

…And Unparalleled Opportunity INNOVATIONS IN BIOLOGY AND TECHNOLOGY CREATE TREMENDOUS OPPORTUNITIES TO ADVANCE MEDICINE, AND WE HAVE THE EXPERTISE AND FORESIGHT TO TAP THEIR POTENTIAL. Penn Vet is part of a world-class university that is home to the top minds in every field of science and encourages the steady flow of ideas and scholarship among them. We stand on the shoulders of the giants of veterinary medicine — Allam, Raker, Detweiler, Jenny, and Boucher, just to name a few — and are ready and able to mentor the next generation of innovators. Twin campuses — one highly urban, the other highly rural — create the ideal environment for translational medicine that transforms research into care.

We will smooth the path for those students who wish to serve in public health and other areas of veterinary medicine where shortages threaten the safety and well-being of society. We will augment our research and teaching capacity by recruiting the best minds to Penn Vet and giving them the tools to create and disseminate knowledge. We will enhance our ability to quickly and efficiently share information to better spot patterns and disease trends. We will integrate our clinical and research strengths on both campuses and apply them to four priority areas: INFECTIOUS DISEASE Uniting basic and clinical research in infectious disease with front-line diagnostic surveillance will enable us to build a powerful base of knowledge and apply it to better control existing diseases and combat emerging ones.

NEUROSCIENCE Penn Vet’s neurologists, neurosurgeons, and researchers will collaborate to advance our understanding of the brain and the nervous system and improve treatment for obesity, epilepsy, encephalitis, and diseases of the brain and spinal cord.

COMPARATIVE ONCOLOGY Cancer is a leading cause of death in dogs and cats. Research that helps these companion animals also has the potential to further our knowledge of the disease in humans. Combining the resources of the School’s Mari Lowe Center for Comparative Oncology with Penn’s renowned Abramson Family Cancer Research Institute positions us as a world leader in comparative oncology.

REGENERATIVE MEDICINE Penn Vet’s historic strengths in genetics and stem cell biology, coupled with recent developments in those areas, spell great promise for our leadership in regenerative medicine, which can lead to faster healing of wounds and fractures and more effective diagnosis and treatment of naturally-occurring diseases in animals and, potentially, humans.

At a Time of Unprecedented Need…

Penn Vet is Prepared to Lead. WE HAVE A CLEAR VISION FOR THE FUTURE. We will increase the size of our incoming classes in both the VMD and VMD-PhD programs to help alleviate national shortages.

3 Investments in three critical areas Realizing great potential requires investments that match our vision. Penn Vet is poised to make an even greater contribution to the big issues of our time. We cannot afford to go backwards. We must invest a total of $125 million in:

People: $43 Million

Space & Tools: $74 Million

Opportunity: $8 Million

STUDENTS Core Scholarships Average starting salaries in veterinary medicine are $65,000 a year, while the average debt load for Penn Vet graduates is $160,000, higher even than medical school. Many young people interested in veterinary medicine find it out of their reach. To ensure a diverse and enlarged student pool that will populate all the fields of veterinary medicine, we seek endowed and term scholarship funding.

GEORGE D. WIDENER HOSPITAL RENOVATIONS Widener Hospital must enhance clinical spaces to match client needs and clinical expertise. Improvements include upgraded surgical suites to give an increasing volume of patients a better experience, enlarged imaging facilities to sharpen teaching and diagnostics, and an indoor complex to allow for safer and more comfortable examination and assessment.

DEAN’S DISCRETIONARY FUND One of the best ways Penn Vet can maintain its position at the top of the profession is to provide its leaders with the discretionary funds to seize the moment. Recruiting top faculty who suddenly become available or offering start-up funds to promising new research gives Penn Vet the extra advantage that often makes the difference between good and great. We seek endowed funds to ensure we maintain the sharpest edge.

Clinical Research Residencies By expanding Penn’s successful clinical residency program to include a core research component in areas such as neuroscience and cardiology, Penn Vet will train the next generation of clinicians and give them the tools they need to help translate research advances into patient care. VMD-PhD Scholarships Penn Vet’s VMD-PhD program is among the best in the world, and its graduates go on to lead research initiatives at academic institutions and in private industry. Candidates combine degrees in veterinary medicine with a focus on biomedical research in areas consistent with the school’s priorities. Enabling students to complete this rigorous program requires endowed and term funding. FACULTY The ability of Penn Vet to lead the profession depends in large part on the strength of its faculty. Endowed professorships are critical to successful faculty recruitment at the highest levels. The income from endowment enables a stable funding stream for use in research and teaching programs, and endowed positions help leverage other talent and funding. To enhance our ability to attract and retain the best faculty, Penn Vet looks to endowed and term professorships. RESEARCH CENTERS AND FUNDING To lead the profession in our four focused areas of research — infectious disease, neuroscience, comparative oncology, and regenerative medicine — Penn Vet needs to support faculty focused on basic, translational, and clinical research who will shape the direction of inquiry. In addition to endowing faculty positions, we must fund each area of core research and inspire and accelerate translational research that will transform patient care.

MATTHEW J. RYAN HOSPITAL RENOVATIONS One of the busiest urban tertiary care centers in veterinary medicine, the Matthew J. Ryan Hospital treats a high volume of diverse patients effectively and efficiently. To continue to offer the best care, we must expand our emergency service and update our imaging, cardiology, and outpatient services. LABORATORY AND RESEARCH SPACE Penn Vet already has the best minds in veterinary science working on research’s toughest questions. To accelerate the pace of discovery, we need to refurbish our space and upgrade our tools. We seek term funding to build the spacious and well-equipped laboratories that are fundamental to inquiry and discovery. NEW BOLTON CENTER TEACHING SPACE Penn Vet must increase and enhance the space available for faculty offices and classroom instruction to meet the planned goal to grow enrollment and add connectivity to share resources between the Philadelphia and Chester County campuses.

SHELTER ANIMAL MEDICINE PROGRAM As one of the only veterinary schools in an urban setting, Penn Vet pioneered the care of homeless animals. To ensure that all animals have access to quality care and help control the spread of disease, we must build an endowment that will expand an already successful program. ANNUAL GIVING In a world that generates new knowledge every single day and communicates it in real time, an education program needs the ability to respond and retool at a moment’s notice. Flexibility and initiative must be among the hallmarks of the Penn Vet experience. A robust annual giving program makes all the difference in our ability to respond quickly to emerging opportunities, to add symposia and bring in guest lecturers on emerging topics of interest, to augment the curriculum, offer seed money, and provide the tools that enhance learning in the classroom and the field.

ELECTRONIC MEDICAL RECORDS To better manage existing hospital cases as well as predict future disease patterns, Penn Vet seeks to build a searchable database with records that can be shared across campuses and sorted by date, species, and type of infection to allow trends to emerge. NEW MULTI-DISCIPLINARY LABORATORIES In this world of rapidly changing technology, Penn Vet students study science in laboratories that date back nearly 40 years. To give students a superior grounding in the basic scientific core of veterinary medicine, we need to build state-of-the-art student learning laboratories commensurate with modern teaching methods.

People: $43 Million

Space & Tools: $74 Million

Opportunity: $8 Million

For a century and a quarter, Penn Vet has been the bellwether of veterinary medicine. Innovation and its application are part of our culture and through their exercise, we have saved lives and minimized suffering. We have changed medical history and benefited animals and humans alike. Leadership of this caliber is expensive to maintain, and we look to those who feel as passionately as we do to help us sustain it. JOIN US IN MAKING HISTORY ONCE AGAIN. Promise. Passion. Purpose. Pride.

Steege/Thomson Communications. Photography: John Donges, Lisa Godfrey, Kathy Kruger, Tommy Leonardi, Sabina Louise Pierce, Jennifer Rench; Derek Croucher/Getty Images; Giel/Getty Images; CDC/ Courtesy of Cynthia Goldsmith; CDC/ Dr. Terrence Tumpey/Cynthia Goldsmith; Rocky Mountain Laboratories, NIAID, NIH

125TH ANNIVERSARY

School of Veterinary Medicine University of Pennsylvania 3800 Spruce Street Philadelphia, PA 19104 215.898.1480 www.vet.upenn.edu