Au Go stra ld lia Sp Da ec y ial Gre Ed en iti & on 22 - 28 January 2013 Issue: 447
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n Scientists say they have discovered a way to turn the HIV into a weapon against itself. Britons struggle
AUSSIE BREAKTHROUGH BRINGS HIV CURE CLOSER By Paul Bleakley A FORM of gene therapy developed by researchers at the Queensland Institute of Medical Research may provide hope to sufferers of HIV, preventing the virus from crippling the immune system by manipulating its genetic structure and turning HIV into a weapon against itself. Dr David Harrich, a naturalised Australian citizen, has utilised a technique that alters the proteins that enable the HIV virus to replicate throughout the body. By modifying the proteins that make up HIV into a mutated form, referred to as Nullbasic, Harrich’s research team have determined that it is possible to block the process of reverse transcription that allows HIV to damage the immune system. This would ultimately render the virus inert, preventing the condition of those infected with HIV from deteriorating further. Harrich began studying the HIV virus in 1989 while completing his doctorate in experimental pathology at the University of California – Los Angeles. This project explored the issue of genetic expression and the replication of the HIV virus, a research concept he would continue to pursue after moving to Australia in 1997. The initial breakthrough in Harrich’s research occurred in 2007, with the discovery that Nullbasic had the ability to inhibit the spread of HIV. Harrich told Australian Times: “With money running out, I had my PhD student try one more experiment
in late 2007. The experiment was to test if Nullbasic could render HIV non-infectious. The student came back and said it worked, so I told him to do it again and again and again. It works every time. “So the project was back on and we received funding from the Australian Centre for HIV and Hepatitis Research and that study showed very clearly that it could protect human cells from HIV infection. Subsequently we have protected primary human CD lymphocytes from blood from HIV infection using a gene therapy approach with outstanding results.” As a researcher with the Queensland Institute of Medical Research, Harrich works with a variety of infectious diseases including human respiratory virus and the Hendra strain of equine influenza. The results of his research regarding HIV may have significant impacts on the study of virology and provide critical insights into preventing the rampant spread of communicable diseases. Harrich’s gene therapy process involves adding a specifically designed HIV therapy agent to a culture of stem cells that causes these cells to become HIV resistant. These mutated stem cells would then be returned to the body with the ability to thwart the HIV virus’s attempts to alter the patient’s RNA structure through reverse transcription. Harrich believes that preventing the exponential replication of the HIV virus would ultimately prevent an ...continued on p3
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with the Aussie citizenship test By Paul Bleakley
Britons and New Zealanders applying for Australian citizenship have been found to have less knowledge about the country that they are emigrating to than applicants from other nations according to figures released by the Federal government this week. Department of Immigration statistics released to The Advertiser show that British applicants for Australian citizenship rank 18th in the world in terms of their results on the test introduced by the Howard government in 2007. Brits scored an average of 95.6% on the test, slightly behind applicants from Colombia and Malaysia. Despite being typically considered the nation that is culturally closest to Australia, applicants for citizenship from New Zealand are shown to be among the world’s worst performers on the test. New Zealanders were shown to score an average of 72.6% on the test designed to determine an applicant’s cultural and historical knowledge about the country in which they are applying to live. This score places New Zealanders 1.4% behind citizens from the impoverished nation of Ethiopia, and only slightly above applicants from ...continued on p3