A4M | Anti-Aging Medical News - Winter 2024 by Tarsus Medical

We’re delighted to welcome you to the electric city of Las Vegas for the 32nd A4M Annual World Congress, now our 3rd official LongevityFest. Whether you’ve traveled from afar or live nearby, attending for the first time or your 32nd, we are grateful for your presence at this landmark gathering.

This year’s theme, “Advancing Longevity Medicine,” embodies our collective mission. At A4M, we propel the longevity domain forward

Timeline of Innovation: HOW WE GOT HERE

1992

by fostering platforms for the interchange of wisdom, the intersection of cross-disciplinary ideas, and pioneering innovation. You, our esteemed guests, advance it daily in your practices. We unite to challenge conventions and disrupt the healthcare status quo, leading by example. Before we push the frontiers of science further, let’s pause to reflect on our journey.

A4M takes its first steps. We witness the invention of the smart pill and the expansion of the CDC’s focus to include disease prevention.

1998

Spearheading the anti-aging specialty, A4M establishes The American Board of Anti-Aging and Regenerative Medicine (ABAARM) and The American Board of Anti-Aging Health Professionals (ABAAHP) to provide a pathway to recognition and Board Certification for practitioners in the field.

2002

The mouse genome is sequenced for the first time, unveiling new frontiers in genetics research and paving the way for personalized, precision medicine. Our understanding of the human body at a molecular level expands exponentially.

2003

A4M launches the Fellowship in Anti-Aging and Metabolic Medicine (FAAMM) program, the first accredited curriculum offering advanced training and expanding access to comprehensive, cutting-edge anti-aging education.

2012

Two decades into our mission, the Nobel Prize is awarded for the discovery of induced pluripotent stem cells, a cornerstone of regenerative therapeutics.

2015

A4M introduces the Fellowship in Stem Cell Therapy, bridging widening gaps between the science and practical, informed applications of regenerative medicine.

2022

An unprecedented rate of advancements emerges: mRNA vaccines leverage genetic technology for disease prevention, GLP-1 agonists reinvent modern metabolic health, and widespread societal shifts reshape our practice with a rising focus on wellbeing and healthy aging.

Today at LongevityFest 2024: Advancing Longevity Medicine

A4M shatters industry records once more, welcoming thousands of front-running physicians, health professionals, and key stakeholders to our flagship event. Awaiting them are three days packed with experiences engineered not only to educate but to engage and enlighten. A rare confluence of visionaries who’ve shaped our specialty – David Sinclair, A.O., PhD, Peter Attia, MD, Gordon Lauc, PhD, Sara Gottfried, MD, Dave Asprey, and others – will take the stage to reshape our approach to age, health, and most importantly, healthy aging.

This moment marks the culmination of our year’s work every year, and we’re honored that you’re an indispensable part of it.

In our fast-paced world of constant innovation, we must pause to acknowledge our achievements. As you read this, take a moment to recognize your personal and professional progress – often the easiest to overlook. Simultaneously, we reflect on our evolution as a community from a gathering of a few forward-thinking professionals to the largest longevity-focused event globally.

To you, our community members – the true torchbearers of this movement – we extend our deepest gratitude. Your trust in what seemed an unreachable vision in 1992 has made this possible. To our team, who not only shares our vision but works tirelessly to make it a reality, we are profoundly thankful.

As we get bigger, we dream bigger. LongevityFest 2024 embodies this spirit, and you continually exceed our expectations, breaking record after record. With that, we officially welcome you to LongevityFest 2024, the next milestone in longevity medicine.

Here’s to the progress we’ve made and the horizons we’ve yet to explore, celebrating every advancement along the way.

Ronald Klatz, MD, DO & Robert M. Goldman, MD, PhD A4M Founders

Ronald Klatz MD, DO Co-Founder

Robert Goldman MD, PhD, DO, FAASP Co-Founder

SHOW REGULATIONS

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ARTICLES

Incretins (GLP-1 and GIP) and the Microbiome

By: Jocelyn Strand, ND, & Shawn Manske, ND

The Fragility and Resilience of the Endothelial Glycocalyx

By: Cardiologist Michael Twyman, MD

Taurine and Glycine: The Benefits of Combining These Two Amino Acids

By: Danielle Moyer Male, MS, CNS, LDN; Clinical Science Writer for Designs for Health

Reducing Cardiovascular Disease Risk Without Statins

By: Leonard Pastrana, PharmD

The Potential of Topical NAD+ as an Anti-Aging Skin Treatment

By: Christopher Lorich, PharmD

Nitric Oxide –Master Hormone And Holy Grail Of Longevity And Anti-Aging

By: Nathan S. Bryan, PhD

Organic Acids, Cognitive Function, and Brain Health

By: Christina O’Brien, DC, RDN, DACNB, IFMCP

Preserve Telomere Health Now: A Clinical Imperative for Preventing Age-Related Diseases and Extending Lifespan

By: Kathleen O’Neil Smith, MD, FAARM

Galectin-3 and Its Association with Dementias: The Potential of TB006 to Reverse Dementias

By: Arbella Sarkis, MD, and John Bumb

By: Adair Anderson, MS, RDN, LDN & Tyana Smith, MA

MEET THE PLANNING COMMITTEE MEMBERS

Our Planning Committee Members are the driving force behind our innovative and cutting-edge programs. Each member brings a wealth of experience, expertise, and a passion for advancing the forefront of medicine. They meticulously develop and curate content that pushes the boundaries of current medical knowledge, ensuring our programs are always ahead of the curve. Through their dedication and vision, we provide an unparalleled platform for learning and discovery, making significant strides in the medical field.

Join us in celebrating the remarkable contributions of our Planning Committee Members, whose commitment to excellence shapes the future of medicine.

Andrew Heyman MD, MHSA, ABFM, ABIHM Director of Academic Affairs

Sahar Swidan PharmD, BCPS, ABAAHP, FAARFM Director of Professional Programming

James LaValle

RPh. CCN, MT

Mark Rosenberg MD, FAARM, ABAARM

Erika Schwartz MD

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Location: Casanova 601

FRIDAY | DECEMBER 13TH

6:15 pm

New Investigational Drug: Unlocking Brain Potential with TB006 and Genomic Science

Presented by: Arbella Sarkis, MD

William Gael, MD

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Incretins (GLP-1 and GIP) and the Microbiome

By: Jocelyn Strand, ND, & Shawn Manske, ND

The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine. The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

Introduction

The use of incretin analogs continues to rise, with their applications expanding rapidly. These drugs target receptors for glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP), hormones released from the gut in response to meals containing glucose and fat. While known for their role in weight loss, these analogs also influence blood sugar control, cardiovascular health, metabolism, and even neurological function. Ongoing research reveals new roles for these hormones, even decades after GLP-1’s discovery.

Whether you’re treating patients with GLP-1/GIP agonists or supporting natural incretin production, a holistic health approach is vital. Gut health, driven by the microbiome, plays a key role in nutrient absorption, inflammation control, immune regulation, and digestive function. The microbiome also helps trigger the production of GLP-1 and GIP, making it essential to understanding incretin function.

Recent studies highlight the complex connection between gut-derived peptides, gastrointestinal health, and the microbiome, deepening our understanding of the microbiome’s role in incretin production and overall physiology.

A quote from Cell captures the significance of this interaction:

“Enteroendocrine cells (EECs) are specialized hormone-producing cells in the gut epithelium that sense changes in the intestinal milieu ... Accordingly, microbial metabolites interact with the EECs to stimulate or suppress hormone secretion, which act through endocrine and paracrine signaling to regulate local intestinal and diverse physiological functions and impact overall host metabolism. The remarkable success of glucagon-like peptide-1based drugs for treatment of type 2 diabetes and obesity highlights the relevance of investigating microbial regulation of EECs to tackle metabolic

Incretins (GLP-1 and GIP) and the Microbiome diseases through novel microbiota-based therapies.”

Epidemiology of Incretin-related Disorders

Incretin-related disorders are linked to metabolic syndrome, a combination of health issues that includes type 2 diabetes (T2DM), obesity, polycystic ovarian syndrome (PCOS), and metabolic-associated fatty liver disease (MAFLD). These conditions also contribute to cardiovascular problems such as hypertension (HTN), dyslipidemia, heart disease, and stroke.

It’s estimated that roughly one-quarter of the global population — over a billion people — are affected by metabolic syndrome.

A recent KFF Health Tracking Poll revealed that about 12% of adults have used a GLP-1 agonist, while 6% are currently using one to manage diabetes or to prevent heart attacks or strokes. Among those taking these medications:

• 43% have diabetes

• 25% have heart disease

• 22% are overweight or obese

Despite rising public awareness and use of incretin-based treatments, many individuals face barriers to accessing these medications due to their high costs and limited insurance coverage.

Physiology and Clinical Relevance

Incretin Physiology

GLP-1 and GIP are peptide hormones released from the gastrointestinal mucosa in response to a meal. GLP-1 originates in enteroendocrine L cells, and GIP is produced and released from K cells.

Both peptides play a primary role in regulating glucose homeostasis. Although both enhance pancreatic insulin secretion, these sister peptides work slightly differently:

GLP-1 GIP

• Enhances pancreatic beta cell insulin secretion

• Stimulates enteric and autonomic reflexes (slows gastric emptying, stimulates vagal sensory neurons that regulate appetite)

• Inhibits pancreatic α-cell glucagon secretion

• Enhances pancreatic insulin secretion

• Stimulates pancreatic α-cell glucagon secretion (more effectively in fasting states)

Because of the breadth of activities initiated by GLP-1 and GIP receptors, their analogs are being studied for a wide range of conditions. While these medications are being utilized primarily for diabetes and weight loss, phase 3 clinical trials are currently underway for:

• Chronic kidney disease

• Alzheimer’s disease

• Heart failure with preserved ejection fraction

• Obstructive sleep apnea

• MASH/NASH

• Cardiovascular health

• Parkinson’s disease

• Cancer

• Skeletal muscle wasting.

Incretins and Diabetes

Type 2 diabetes mellitus (T2DM) is marked by the impaired function of the GIP receptor (GIPR) in both pancreatic α and β cells, resulting in reduced insulin secretion after meals and causing hyperglycemia.

GLP-1 acts in a glucose-dependent manner, meaning it lowers blood sugar only when glucose levels are

elevated, such as after eating. Once blood glucose returns to fasting levels, GLP-1 is broken down by the enzyme dipeptidyl peptidase-IV (DPP-IV), preventing hypoglycemia.5 Because of this mechanism, GLP-1 receptor agonists and DPP-IV inhibitors are used as therapeutic agents in managing T2DM. Furthermore, studies indicate that GLP-1 and GLP-1 receptor agonists enhance insulin sensitivity and improve pancreatic β-cell function, promoting better glucose regulation.5

Incretins and Obesity and Weight Management

Obesity, defined as a BMI over 30 kg/m² with excessive body fat, is a global epidemic linked to metabolic syndrome, osteoarthritis, sleep apnea, GERD, liver disease, cancer, and increased mortality.

GLP-1 not only regulates blood sugar and insulin resistance but also promotes weight loss by slowing gastric emptying and increasing feelings of fullness, leading to reduced food intake.8

The role of GIP in weight regulation is less clear. Traditionally associated with weight gain due to its role in fat storage after nutrient intake, recent studies suggest both GIP receptor agonism and antagonism can aid in weight loss.

Moreover, co-administration of GLP-1 and GIP receptor agonists (e.g., tirzepatide) enhances weight loss and reduces BMI, waist circumference, blood glucose, and HbA1c more effectively than GLP-1 receptor agonists alone.8

Incretins, Cardiovascular Health, and Other Benefits

GLP-1 and GIP have both direct and indirect effects on the cardiovascular system. GLP-1R and GIPR are found in cardiomyocytes and endothelial cells in the heart and blood vessels, while GLP-1R alone is found in vascular smooth muscle cells of blood vessels and the kidneys. They have cardioprotective, nephroprotective, and antiinflammatory actions. Mechanisms linking GLP-1 and GIP to cardiovascular outcomes remain unclear. However,

their ability to reduce blood glucose, blood pressure, body weight, systemic inflammation, and postprandial lipaemia influences favorable reductions in cardiovascular risks.

GLP-1 influences cardiovascular health in the following ways:

● Reduction of gut lipoprotein secretions

● Decreased platelet aggregation

● Reduced infarct size and improved ventricular function in those with myocardial infarction

● Diminished plaque burden and aortic inflammation

● Cardioprotective actions in those with ischemic cardiac injury.9

GIP likely plays a role in the suppression of macrophagedriven inflammation and foam cell formation, leading to lower risks of atherosclerosis, hypertensive cardiomyopathy, and myocardial infarctions.9

Incretins and Neuroinflammation

Metabolic syndrome and insulin resistance are key factors in the development of neurodegenerative diseases like Alzheimer’s and Parkinson’s. Brain insulin resistance disrupts glucose metabolism, leading to high blood sugar, lipid imbalances, chronic neuroinflammation, and increased blood-brain barrier (BBB) permeability. This activates microglial cells, which release pro-inflammatory cytokines and astrocytes, fueling a cycle of neuroinflammation and hyperglycemia. Other effects include:10

● Vascular dysfunction, contributing to dementia

● Nitric oxide toxicity, causing nerve cell death

● Oxidative stress, leading to neuron loss and higher dementia risk

● Excessive mitochondrial respiration, increasing ROS and NF-κB activation

GLP-1/GIP-based drugs, initially for metabolic conditions, are being studied for neurodegenerative diseases. Incretin receptors in neurons, microglia, and astrocytes exhibit anti-inflammatory, neuroprotective, and neurotrophic effects. Studies show GLP-1 protects

Incretins

(GLP-1 and GIP) and the Microbiome

rat hippocampal neurons from glutamate excitotoxicity, reverses inflammation-induced synaptic impairments, and reduces amyloid-β neurotoxicity. Additionally, mice with higher GLP-1 levels showed improved memory, cognition, neural growth, and motor abilities.10

Research shows that the microbiome influences the physiology of incretins in several ways:

● Bile Acids. Bile acids (BAs) are second only to macronutrients in stimulating GLP-1 release. The

Figure 1. GLP-1 agonists and neuroinflammation overview. From Kopp KO, Glotfelty EJ, Li Y, Greig NH. Glucagon-like peptide-1 (GLP-1) receptor agonists and neuroinflammation: Implications for neurodegenerative disease treatment. Pharmacol Res. 2022;186:106550. doi:10.1016/j.phrs.2022.106550

The Role of the Microbiome

The microbiome influences host GLP-1 production and release through a complex and dynamic combination of signaling pathways mediated by the EECs, shaping the gut-liver axis, production of short-chain fatty acids (SCFAs), and maintenance of the integrity of the intestinal epithelium. The presence of a healthy microbiota affects L-cell differentiation and secretion of incretins and, as such, is required for normal GLP-1 production and release – in particular, postprandial response.

microbiome plays a key role in the Gut-Liver Axis (GLA) by regulating bile production and release. BAs, released by the liver into the small intestine, help maintain GLA homeostasis by emulsifying fats and acting as antimicrobials to control bacterial overgrowth. Uncontrolled overgrowth leads to proinflammatory metabolites, driving chronic diseases. Excess secondary BAs can cause inflammation, cholestasis, gallstones, and cancer. A healthy microbiome mitigates these effects by producing short-chain fatty acids (SCFAs), which have anti-inflammatory properties.

● SCFAs. In addition to exerting both local and systemic anti-inflammatory effects, SCFAs influence the production and release of GLP-1 and

GIP. Butyrate has been shown to cause a transient increase in both of these incretins, while other SCFAs have mixed effects. More research is needed

Slowed digestion, whether from the stomach, gallbladder, or pancreas, can contribute to various diseases by inflaming the intestinal lining and disrupting incretin production.

Figure 2. Microbial regulation of host metabolism via gut hormone release. From Martin AM, Sun EW, Rogers GB, Keating DJ. The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release. Front Physiol. 2019;10:428. Published 2019 Apr 16. doi:10.3389/fphys.2019.00428

to identify the intricacies involved. Still, it is clear that a healthy microbiome plays a significant role in maintaining healthy incretin signaling, mediated in part by the production of SCFA.

● Dysbiosis. Damage caused by proinflammatory mediators generated in the presence of dysbiosis can affect the integrity of the GI epithelium, including enteroendocrine cells (EECs) responsible for the production of GLP-1 and GIP.

Clinical Support for Incretin Analog Therapies

Support gastric motility, gallbladder, and pancreatic function

Patients on high-dose GLP-1/GIP analogs often experience delayed gastric emptying and cholestasis, leading to common side effects like nausea, vomiting, diarrhea, and constipation.

Botanicals and nutrients offer a natural way to support digestion through multiple pathways. Incorporating these can promote bile and pancreatic enzyme production, helping to reduce the side effects of incretin therapies while supporting the gut-liver axis, gut lining, and microbiome, encouraging natural GI peptide production.

Include detoxification support

Incretin analogs slow gastric emptying and reduce food intake, disrupting gastrointestinal hormone

Incretins (GLP-1 and GIP) and the Microbiome

regulation and affecting bile and pancreatic enzyme release, which are essential for toxin excretion.,

Rapid weight loss can release fat-stored toxins faster than the liver, kidneys, and GI tract can detoxify, overwhelming the body’s detox pathways. Microbial dysbiosis also contributes to toxin buildup, disrupting the gut-liver axis, SCFA production, and increasing harmful metabolites like lipopolysaccharides.

To support detoxification during weight loss, restoring microbial balance and enhancing toxin elimination is important. Nutritional support for detox pathways and binders to aid stool excretion can help manage toxins and microbial waste.

Address dietary patterns to establish a new and healthier relationship with food

Many patients seeking weight loss have already struggled with yo-yo dieting, cravings, or disordered eating, often after years of restrictive eating and intense exercise without success. They may also face physical discomfort, bias, shame, and harsh internal dialogue, leading to frustration, mental health challenges, and despair. For these individuals, reducing the constant focus on food is a significant relief, and one key benefit

of GLP-1 agonists is their ability to achieve this.

Research shows that GLP-1 receptor activation in the brain promotes neuroplasticity, offering neuroprotective, neurotrophic, and neuroregenerative effects. This can help break entrenched patterns and form new neural connections, potentially alleviating diet-related mental struggles. By encouraging patients to focus on nourishing their bodies and microbiome during this period, GLP-1/GIP agonists can support lasting changes in diet, lifestyle, and overall health.

Conclusion

Incretin analogs, particularly GLP-1 and GIP agonists, offer promising therapeutic benefits beyond weight loss, including improved glucose regulation and cardiovascular health as well as neuroprotection. As research into these hormones and their analogs continues to expand, understanding their relationship to gut health and the microbiome is essential. A holistic approach that supports digestion, detoxification, and mental well-being can enhance the efficacy of incretin-based therapies, providing patients with sustainable improvements in metabolic, cardiovascular, and neurological health.

Authors Bios:

Jocelyn Strand, ND, is Senior Director of Clinical Education and Research for Biocidin Botanicals. Previously, Dr. Strand was a primary care provider in clinical practice for 11 years. Contact her at drstrand@ biocidin.com or 800.775.4140.

Shawn Manske, ND, is the Assistant Director of Clinical Education for Biocidin Botanicals. He previously worked in clinical practice focusing on GI dysfunction and autoimmune disease. Contact him at drmanske@ biocidin.com or 800.775.4140

References:

1. Seino Y, Fukushima M, Yabe D. GIP and GLP-1, the two incretin hormones: Similarities and differences. J Diabetes Investig. 2010;1(1-2):8-23. doi:10.1111/j.2040-1124.2010.00022.x

2. Arora T, Vanslette AM, Hjorth SA, Bäckhed F. Microbial regulation of enteroendocrine cells. Med. 2021;2(5):553-570. doi:10.1016/j. medj.2021.03.018

3. Saklayen MG. The Global Epidemic of the Metabolic Syndrome. Curr Hypertens Rep. 2018;20(2):12. Published 2018 Feb 26. doi:10.1007/s11906018-0812-z

4. Montero A, Sparks G, Presiado M, Hamel L. KFF Health Tracking Poll May 2024: The Public’s Use and Views of GLP-1 Drugs | KFF. KFF. Published May 10, 2024. https://www.kff.org/health-costs/poll-finding/ kff-health-tracking-poll-may-2024-the-publics-use-and-views-of-glp-1drugs/#:~:text=One%20in%20Eight%20Adults%20Say

5. Nadkarni P, Chepurny OG, Holz GG. Regulation of glucose homeostasis by GLP-1. Prog Mol Biol Transl Sci. 2014;121:23-65. doi:10.1016/B978-0-12800101-1.00002-8

6. Buntz B. Beyond diabetes and obesity: Can GLP-1 therapies also transform chronic disease treatment? - Drug Discovery and Development. Drug Discovery and Development. Published February 13, 2024. Accessed September 18, 2024. https://www.drugdiscoverytrends.com/beyond-diabetesand-obesity-can-glp-1-therapies-also-transform-chronic-disease-treatment/

7. El K, Campbell JE. The role of GIP in α-cells and glucagon secretion. Peptides. 2020 Mar;125:170213. doi: 10.1016/j.peptides.2019.170213. Epub 2019 Nov 27. PMID: 31785304; PMCID: PMC7580028

8. Zaffina I, Pelle MC, Armentaro G, et al. Effect of dual glucose-dependent insulinotropic peptide/glucagon-like peptide-1 receptor agonist on weight loss in subjects with obesity. Front Endocrinol (Lausanne). 2023;14:1095753. Published 2023 Feb 22. doi:10.3389/fendo.2023.1095753

9. Campbell JE. Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms. Mol Metab. 2021;46:101139. doi:10.1016/j. molmet.2020.101139

10. Kopp KO, Glotfelty EJ, Li Y, Greig NH. Glucagon-like peptide-1 (GLP-1) receptor agonists and neuroinflammation: Implications for neurodegenerative disease treatment. Pharmacol Res. 2022;186:106550. doi:10.1016/j. phrs.2022.106550

11. Zeng Y, Wu Y, Zhang Q, Xiao X. Crosstalk between glucagon-like peptide 1 and gut microbiota in metabolic diseases. mBio. 2024;15(1):e0203223. doi:10.1128/mbio.02032-23

12. Wang Q, Lin H, Shen C, et al. Gut microbiota regulates postprandial GLP-1 response via ileal bile acid-TGR5 signaling. Gut Microbes. 2023;15(2):2274124. doi:10.1080/19490976.2023.2274124

13. Everard A, Cani PD. Gut microbiota and GLP-1. Rev Endocr Metab Disord. 2014;15(3):189-196. doi:10.1007/s11154-014-9288-6

14. Strand J. Distinctive Detoxification: The Case for Including the Microbiome in Detox Strategy. Integr Med (Encinitas). 2022 Sep;21(4):26-30. PMID: 36644597; PMCID: PMC9542931

15. Arora T, Vanslette AM, Hjorth SA, Bäckhed F. Microbial regulation of enteroendocrine cells. Med. 2021;2(5):553-570. doi:10.1016/j. medj.2021.03.018

16. Catanese L. GLP-1 diabetes and weight-loss drug side effects: Harvard Health. Published February 5, 2024. https://www.health.harvard.edu/stayinghealthy/glp-1-diabetes-and-weight-loss-drug-side-effects-ozempic-face-andmore

17. Aldawsari M, Almadani FA, Almuhammadi N, Algabsani S, Alamro Y, Aldhwayan M. The Efficacy of GLP-1 Analogues on Appetite Parameters, Gastric Emptying, Food Preference and Taste Among Adults with Obesity: Systematic Review of Randomized Controlled Trials. Diabetes Metab Syndr Obes. 2023;16:575-595. Published 2023 Mar 2. doi:10.2147/DMSO.S387116

18. Camilleri M. Gastrointestinal hormones and regulation of gastric emptying. Curr Opin Endocrinol Diabetes Obes. 2019;26(1):3-10. doi:10.1097/ MED.0000000000000448

19. Hayashi D, Edwards C, Emond JA, et al. What Is Food Noise? A Conceptual Model of Food Cue Reactivity. Nutrients. 2023;15(22):4809. Published 2023 Nov 17. doi:10.3390/nu15224809

20. Salcedo I, Tweedie D, Li Y, Greig NH. Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders. Br J Pharmacol. 2012;166(5):1586-1599. doi:10.1111/j.1476-5381.2012.01971.x

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The Fragility and Resilience of the Endothelial Glycocalyx

By: Cardiologist Michael Twyman, MD

“The rule of the artery is absolute, universal, and it must be unobstructed, or disease will result.”

–A.T. Still, founder of osteopathy

ABOUT THE GLYCOCALYX

The endothelial glycocalyx (EGX) plays a pivotal role in vascular function and overall human health. This delicate coating blankets the innermost surface of all blood vessels, giving it an indispensable role in cardiovascular functioning1. The EGX provides a dynamic and responsive semi-permeable barrier between the ﬂowing blood and the endothelial cells.2

The EGX is comprised of glycosaminoglycans (GAGs) such as heparan sulfate, chondroitin sulfate, and hyaluronan, and it structurally adheres to the endothelium through proteoglycans like syndecan-1 — which provides the primary backbone of the EGX — and glycoproteins such as CD44, which serves as a receptor for hyaluronan.

These GAGs and core proteins together form an intricate network that ensure the integrity and effective functioning of the glycocalyx.5

The EGX plays a decisive role in preserving the stability of the vascular system by modulating vascular permeability and microvascular tone6. It serves as a protective barrier against intrusion by lipoproteins and other blood contents, while also regulating the adherence of platelets and leukocytes.7

Another crucial function of the glycocalyx is its role as a mechanosensor, converting the shear stress generated from blood ﬂow into intracellular signals within the vascular system.1 A key example is the endothelial production of nitric oxide (NO), which serves as an essential vasodilator and regulator of

[Van den berg image]

Caption: First visualized in 1966 via transmission electron microscopy3, here seen by Van den Berg et al 2003.4

[Image of healthy/unhealthy EGX with blood ﬂowing]

Caption: When healthy, the endothelial glycocalyx protects the endothelium as a semi-permeable barrier, while also harboring important antioxidants and molecules and triggering nitric oxide production through the eNOS pathway.

Without a healthy endothelial glycocalyx, a healthy vascular system is impossible. Needless to say, without a healthy vascular system, no organ or system in the body is safe from perturbation.

CAUSES OF ENDOTHELIAL GLYCOCALYX DEGRADATION

Endothelial glycocalyx degradation can result from a wide variety of factors and conditions that compromise the glycocalyx’s production and structural integrity. In many conditions, both acute and chronic, major constituents of the glycocalyx, such as syndecans, heparan sulfates, and hyaluronan, are shed from the endothelial surface9

While not yet ready for routine clinical use, there are urine and blood tests that can measure the amount of shedded glycosaminoglycan (GAG) components of the glycocalyx, indicating degradation. This area of research of the GAGome is ongoing.10 This shedding exposes cell surface receptors to the ﬂowing blood, making endothelial cells more susceptible to insult from lipoproteins and other blood contents.11

The greatest threat to the endothelial glycocalyx comes from inﬂammatory and oxidative processes.

For example, hyperglycemia, a potent pro-oxidant, is known to degrade the glycocalyx.12 In individuals with Type 1 diabetes, the glycocalyx is half the thickness of healthy controls, and it is thinner still in diabetics with microalbuminuria.13 Microalbumin tests are quick and simple ways to assess the blood vessel (and, by extension EGX) health at the level of the renal arteries.

Even absent diabetes, high blood sugar poses a signiﬁcant threat to the integrity of the EGX, and hence of the vascular system as a whole.

Inﬂammatory mechanisms activated during sepsis can degrade and effectively destroy the glycocalyx. These pro-inﬂammatory components include matrix metalloproteinases (MMPs), heparanase, and hyaluronidase, and cytokines like tumor necrosis factor-alpha (TNF-α) and interleukin-1beta.[4]

Studies indicate that the presence of low-density lipoprotein may lead to glycocalyx degradation, triggering local platelet adhesion. Conversely, the

loss of glycocalyx protection enables these harmful components to penetrate the endothelial wall. [10]

Lipopolysaccharide (LPS), a bacterial glycoprotein, can almost entirely remove the endothelial glycocalyx in cardiac and pulmonary capillaries. [8] Additionally, ischemia, worsened by oxygenfree radicals during reperfusion, can cause almost complete glycocalyx degradation.[10]

Lastly, age-related thinning of the EGX has been observed in the microvasculature of both mice and humans, indicating that advancing age alone can contribute to glycocalyx damage and resulting health impacts.14, 15

THE EFFECTS OF GLYCOCALYX DEGRADATION

Endothelial glycocalyx degradation has signiﬁcant implications for organ function and overall health.

Sometimes, a vicious cycle sets in: the organ dysfunction that follows from endothelial injury can trigger further microcirculatory dysfunction, which then escalates into organ ischemia and additional organ damage. [8] The degradation of the endothelial glycocalyx that has been observed in a wide range of pathological and physiological conditions may be an expression of this circular logic. These conditions can include cardiovascular disease, arteriosclerosis, hypertension, hypoxia, renal disease, sepsis, acute respiratory distress syndrome, and certain viral infections. [8]

The shedding of the EGX increases the permeability of the endothelial wall, and this can lead to tissue edema, potentially heightening organ dysfunction and failure16. Other results of EGX degradation include platelet aggregation, leukocyte adhesion, escalated inﬂammation, hypercoagulability, and an overall loss of vascular responsiveness.[10] Additionally, an excessively permeable endothelial layer is more susceptible to intrusion by lipoproteins and macrophages, leading to the formation of atherosclerotic plaque.17

[compromised EGX image]

Caption: As the endothelial glycocalyx degrades, the endothelium is increasingly likely to have damage, accumulated particles, and impeded blood ﬂow.

RESTORATION OF THE EGX

Many of the most common methods to protect cardiovascular health actually work by protecting the endothelial glycocalyx. For clinicians looking to get upstream and protect longevity and healthspan, the many exposures associated with EGX degradation argue for early restoration to enhance prognosis in a wide variety of conditions.

5 Strategies for Endothelial Glycocalyx Protection & Restoration:

1. Providing glycocalyx support through dietary supplements

2. Lipid level control - usually reduction

3. Insulin management, through dietary, pharmaceutical, and/or supplement interventions

4. For individuals with immune overactivation, consider Immunosupression (Hydrocortisone, Etanercept, Poloxamer-188

5. Anticoagulation (Antithrombin and Heparin)

Promising but early pharmaceutical approaches:

A number of pharmacological agents display potential for diminishing glycocalyx shedding. Antithrombin and hydrocortisone have both been shown to protect the EGX, with electron microscopy revealing a mostly intact glycocalyx after treatment.18

Rosuvastatin has been shown to partially restore EGX volume in familial hypercholesterolemia, though it remains unclear whether this effect is due to the statin itself or to a reduced lipid burden, especially as EGX permeability was still elevated.[10] For prevention, lowering Apo B and oxLDL particles would still be beneﬁcial to avoid damaging EGX in the ﬁrst place.

Others: Clinical evidence has indicated potential beneﬁts of sulodexide, a mixture of natural porcine heparan and dermatan sulfates. When taken orally, these sulfates are broken down in the digestive tract to N-acetylglucosamine moieties, which may enable the synthesis of glycosaminoglycans in the endothelial glycocalyx.[7]

Other promising treatments include antioxidants like: NAC infusion,19 or polyethylene glycol, TNF-α inhibitors, and allopurinol.[10] Other potential agents for repair include tetramethylpyrazine (TMP), an antioxidant and antiinﬂammatory compound found in Chinese herbal medicine, and thrombomodulin, a component of the endothelium that physiologically protects the EGX,20 and hyaluronan and chondroitin sulfates, both key components of the glycocalyx. [10] Lastly, promoting the expression of glycocalyx synthesis genes could theoretically aid in repairing the EGX, and may suggest new avenues for research.[17]

Dietary Supplements: Rhamnan sulfate from Monostroma nitidum

Clinicians seeking a non-pharmaceutical approach to EGX restoration may consider the organic compound rhamnan sulfate (RS) extract. An extract of rhamnan sulfate from Monostroma nitidum,

a green seaweed, has had beneﬁcial effects on a range of cardiovascular parameters. Beneﬁts have included:

• Inhibition of thrombosis21,22

• Reduction of atherosclerotic plaque23

• Reduction of vessel permeability to LDL24

• Lipid reduction25

CONCLUSION

More than 50 years after its discovery, the endothelial glycocalyx is the subject of an accelerating wave of scientiﬁc research. The more that is known about this massive but delicate structure, the more its central role in human health becomes clear . Translation of the science to clinical application is slowly taking place, but there is still a gap between what is known and what is implemented.

The EGX lies upstream of every major vascular function, and is therefore implicated in all the problems that ensue from vascular dysfunction. There is every reason to make protecting the endothelial glycocalyx a clinical priority.

References:

1. Pillinger, N. L., and P. C. A. Kam. “Endothelial Glycocalyx: Basic Science and Clinical Implications.” Anaesthesia and Intensive Care, vol. 45, no. 3, May 2017, pp. 295–307, https://doi.org/10.1177/0310057X1704500305.

2. Lipowsky, Herbert H. “The Endothelial Glycocalyx as a Barrier to Leukocyte Adhesion and Its Mediation by Extracellular Proteases.” Annals of Biomedical Engineering, vol. 40, no. 4, Apr. 2012, pp. 840–48, https://doi. org/10.1007/s10439-011-0427-x.

3. Luft JH. Fine structures of capillary and endocapillary layer as revealed by ruthenium red. Fed Proc. 1966;25(6):1773-1783.

4. van den Berg BM, Vink H, Spaan JA. The endothelial glycocalyx protects against myocardial edema. Circ Res. 2003;92(6):592-594. doi:10.1161/01. RES.0000065917.53950.75

5. Reitsma, Sietze, et al. “The Endothelial Glycocalyx: Composition, Functions, and Visualization.” Pflügers Archiv - European Journal of Physiology, vol. 454, no. 3, June 2007, pp. 345–59, https://doi.org/10.1007/s00424-007-02128.

6. Uchimido, Ryo, et al. “The Glycocalyx: A Novel Diagnostic and Therapeutic Target in Sepsis.” Critical Care (London, England), vol. 23, no. 1, Jan. 2019, p. 16, https://doi.org/10.1186/s13054-018-2292-6.

7. Mitra, Ronodeep, et al. “Glycocalyx in Atherosclerosis-Relevant Endothelium Function and as a Therapeutic Target.” Current Atherosclerosis Reports, vol. 19, no. 12, 2017, https://doi.org/10.1007/s11883-017-0691-9.

8. Nieuwdorp, Max, et al. “Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo.” Diabetes, vol. 55, no. 2, Feb. 2006, pp. 480–86, https:// doi.org/10.2337/diabetes.55.02.06.db05-1103.

“The paradox of the glycocalyx is its combination of extreme fragility — rapid collapse in response to a multitude of stimuli — and its equally remarkable resilience.

The EGX naturally rebuilds itself when conditions allow. When conditions are adverse, research has revealed many potential interventions to support its regeneration and protection. As cardiovascular disease maintains its status as the leading cause of death, this new science should encourage far more clinical application, especially in the ﬁeld of increasing healthy years lived.

9. Degradation of the Endothelial Glycocalyx in Clinical Settings: Searching for the Sheddases - Becker - 2015 - British Journal of Clinical PharmacologyWiley Online Library. https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/ bcp.12629. Accessed 5 July 2023.

10. Chen YH, Narimatsu Y, Clausen TM, et al. The GAGOme: a cell-based library of displayed glycosaminoglycans. Nat Methods. 2018;15(11):881-888. doi:10.1038/s41592-018-0086-z

11. Suzuki, Akio, et al. “Form Follows Function: The Endothelial Glycocalyx.” Translational Research, vol. 0, no. 0, Apr. 2022, https://doi.org/10.1016/j. trsl.2022.03.014.

12. Nieuwdorp, Max, et al. “Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo.” Diabetes, vol. 55, no. 2, Feb. 2006, pp. 480–86, https:// doi.org/10.2337/diabetes.55.02.06.db05-1103.

13. Alphonsus, C. S., and R. N. Rodseth. “The Endothelial Glycocalyx: A Review of the Vascular Barrier.” Anaesthesia, vol. 69, no. 7, 2014, pp. 777–84, https:// doi.org/10.1111/anae.12661.

14. Machin, Daniel R., et al. “Advanced Age Results in a Diminished Endothelial Glycocalyx.” American Journal of Physiology-Heart and Circulatory Physiology, vol. 315, no. 3, Sept. 2018, pp. H531–39, https://doi.org/10.1152/ ajpheart.00104.2018.

15. Taddei S, Virdis A, Ghiadoni L, et al. Age-related reduction of NO availability and oxidative stress in humans. Hypertension. 2001;38(2):274279. doi:10.1161/01.hyp.38.2.274

16. Hemorrhagic Shock and Resuscitation Causes Glycocalyx Shedding and Endothelial Oxidative Stress Preferentially in the Lung and

The Fragility and Resilience of the Endothelial Glycocalyx

Intestinal Vasculature - PubMed. https://pubmed.ncbi.nlm.nih.gov/34259440/. Accessed 5 July 2023.

17. Bobryshev, Yuri V., et al. “Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis.” BioMed Research International, vol. 2016, 2016, p. 9582430, https://doi. org/10.1155/2016/9582430.

18. Chappell, Daniel, et al. “TNF-Alpha Induced Shedding of the Endothelial Glycocalyx Is Prevented by Hydrocortisone and Antithrombin.” Basic Research in Cardiology, vol. 104, no. 1, Jan. 2009, pp. 78–89, https://doi. org/10.1007/s00395-008-0749-5.

19. Rosuvastatin Therapy in Patients with Heterozygous Familial Hypercholesterolemia.” Journal of Lipid Research, vol. 50, no. 1, Jan. 2009, pp. 148–53, https://doi.org/10.1194/jlr.P800025-JLR200

20. Lei, Jin, et al. “Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NF-ΚB/HPSE1 Signaling Pathway During Inflammation.” Frontiers in Pharmacology, vol. 12, 2021, p. 791841, https://doi.org/10.3389/fphar.2021.791841.

21. Okamoto, Takayuki, et al. “Rhamnan Sulfate Extracted from Monostroma Nitidum Attenuates Blood Coagulation and Inflammation of Vascular Endothelial Cells.” Journal of Natural Medicines, vol. 73, no. 3, June 2019, pp. 614–19, https://doi.org/10.1007/s11418-019-01289-5.

22. Liu X, Wang S, Cao S, et al. Structural Characteristics and Anticoagulant Property In Vitro and In Vivo of a Seaweed Sulfated Rhamnan. Marine Drugs. 2018;16(7):243. doi:10.3390/md16070243

23. Patil, Nikita P., et al. Rhamnan Sulfate Reduces Atherosclerotic Plaque Formation and Vascular Inflammation. bioRxiv, 10 Feb. 2022, p. 2022.02.10.479785, https://www.biorxiv.org/ content/10.1101/2022.02.10.479785v1.

24. Cancel LM, Tarbell JM. Rhamnan sulfate enhances the endothelial glycocalyx and decreases the LDL permeability of human coronary artery endothelial cells in vitro. The FASEB Journal. 2013;27(S1):896.3-896.3. doi:https://doi. org/10.1096/fasebj.27.1_supplement.896.3

25. Shimada Y, Zang L, Ishimaru T, et al. Lipid- and glucose-lowering effects of Rhamnan sulphate from Monostroma nitidum with altered gut microbiota in mice. Food Science & Nutrition. n/a(n/a). doi:10.1002/fsn3.4100

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Taurine and Glycine: The Benefits of Combining These Two Amino Acids

By:

Danielle Moyer Male, MS, CNS, LDN Clinical Science Writer for Designs for Health

Dietary Intake of Taurine and Glycine

Maintaining our health as we age becomes increasingly important, and nutrition plays a crucial role. Among the many nutrients that support healthy aging, taurine and glycine stand out due to their numerous synergistic bodily functions that support overall health. Although our bodies can produce these amino acids endogenously, the natural aging process can lead to a decline in the synthesis of taurine and glycine.1,2 Additionally, dietary intake of taurine and glycine may not always meet our body’s needs, especially for individuals with low protein intake, vegetarians, or vegans.3,4 Thus, supplementation may be supportive for certain individuals to support healthy aging.

Taurine, a sulfur-containing, conditionally essential amino acid, is abundant in the brain and skeletal and cardiac muscles.5 It is found almost exclusively in animal-based foods such as meat, seafood, fish, and milk (it has been discovered that certain types

of seaweed may be an exception).6,7 Glycine, the simplest and smallest amino acid, has a hydrogen atom side chain and is also considered conditionally essential.8 Glycine can be found in various animaland plant-based protein sources. Epidemiological studies reveal that a low dietary intake of taurine is associated with higher cardiovascular risks,9 while recent studies suggest that glycine levels may be reduced in adults with obesity, morbid obesity, type 2 diabetes, and non-alcoholic fatty liver disease.10,11

Taurine’s Role in Healthy Aging

Taurine supports healthy aging through various ways:

• Metabolic Health: Taurine promotes normal insulin metabolism, healthy blood sugar metabolism, and healthy lipid metabolism.12–14 A worldwide epidemiological WHO-CARDIAC study surveyed 3,960 individuals from 41 populations. It concluded that the dietary intake of taurine had a significantly inverse relationship to

the values of body mass index (BMI), blood pressure, total cholesterol, and atherogenic index – all of which are risk factors in metabolic conditions.15

• Mitochondrial Function: It supports mitochondrial health, essential for energy production and cellular function.2

• Cognitive Health: Concentrated in the brain, taurine acts as a neurotransmitter or neuromodulator, influencing mood, behavior, memory, and learning.16 It may help to mitigate excitotoxicity by modulating neurotransmission and calcium homeostasis.4,5

• Cardiovascular Health: Taurine supports normal blood pressure by regulating vascular relaxation and promoting nitric oxide (NO) bioavailability.16–18

• Antioxidant Status and Inflammatory Responses: Taurine mitigates oxidative and nitrosative stress, scavenges free radicals and reactive oxygen species (ROS), helps mitigate lipid peroxidation, and supports the antioxidant activity of enzymes like superoxide dismutase and glutathione peroxidase.16,19,20 It also helps to mitigate the production of inflammatory mediators like tumor necrosis factor-alpha, prostaglandin E2, and interleukin-6, and reduce the formation of advanced glycation end-products (AGEs).19,21

• Other Important Roles: Taurine supports healthy bile acid conjugation (supporting fat digestion and absorption), detoxification, and osmoregulation.5

Glycine’s Role in Healthy Aging

Glycine is essential for various functions to support overall health:

• Precursor to Important Metabolites: Glycine is necessary for synthesizing creatine, glutathione, heme, purines, porphyrins, and collagen.3

• Antioxidant Status and Inflammatory Responses: Glycine may promote healthy inflammatory responses during aging by helping to combat “inflammaging.”22,23 As a precursor to glutathione, glycine helps attenuate the adverse effects of oxidative stress.3 Endogenous glutathione synthesis declines

with age, and glycine supplementation has been shown to support healthy glutathione status.3,24

• Neurotransmitter Function and Healthy Sleep Quality: Glycine acts as an inhibitory neurotransmitter and a co-agonist for N-methylD-aspartate (NMDA) receptors, supporting sleep quality and potentially benefiting mood and physiological stress responses.25 In a cross-over trial, volunteers who took 3 g of glycine before bedtime experienced significantly improved “liveliness and peppiness”, “clear-headedness”, and reduced fatigue symptoms the following morning.26 Furthermore, a review demonstrated that 9 g/day of glycine supplementation did not induce daytime drowsiness.27

• Musculoskeletal Health: Glycine promotes collagen synthesis, which is essential for musculoskeletal health.28 Glycine has been shown in vitro and clinically to support healthy tendon recovery and promote cartilage regeneration for individuals with certain conditions, such as Achilles tendinopathy or osteoarthritis.29,30

• Other Important Roles: Glycine supports mitochondrial health.31 Similar to taurine, glycine also promotes the conjugation of bile salts and the digestion and absorption of fats and fat-soluble nutrients.8

The Synergy of Taurine and Glycine

Combining taurine and glycine can offer synergistic benefits for healthy aging. Both amino acids support antioxidant status, mitigate oxidative stress, and promote overall cellular health. Their roles in normal neurotransmitter function and cognitive health complement each other, potentially supporting healthy sleep hygiene, stress responses, and balanced mood. Additionally, their combined benefits on cardiovascular and metabolic health can provide a more comprehensive approach to maintaining health as we age. While taurine and glycine individually offer significant health benefits, their combination can provide a powerful strategy to support healthy aging.

Author Bio:

Danielle Moyer Male has an M.S. in Nutrition and is a board-Certified Nutrition Specialist® and a Licensed Dietitian Nutritionist. She is a Clinical Science Writer for Designs for Health, and teaches college-level nutrition. dmoyer@designsforhealth.com

Designs for Health (DFH) is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.* This dedication to quality and passion for the industry, along with the DFH team who share these values, is why DFH customers have remained loyal to the brand for 35 years.

References:

1. Ding Y, Svingen GFT, Pedersen ER, et al. Plasma glycine and risk of acute myocardial infarction in patients with suspected stable angina pectoris. J Am Heart Assoc. 2015;5(1):e002621. doi:10.1161/JAHA.115.002621

2. Singh P, Gollapalli K, Mangiola S, et al. Taurine deficiency as a driver of aging. Science. 2023;380(6649):eabn9257. doi:10.1126/science.abn9257

3. McCarty MF, O’Keefe JH, DiNicolantonio JJ. Dietary glycine is rate-limiting for glutathione synthesis and may have broad potential for health protection. Ochsner J. 2018;18(1):81-87.

4. Ramírez-Guerrero S, Guardo-Maya S, Medina-Rincón GJ, Orrego-González EE, CabezasPérez R, González-Reyes RE. Taurine and astrocytes: a homeostatic and neuroprotective relationship. Front Mol Neurosci. 2022;15:937789. doi:10.3389/fnmol.2022.937789

5. El Idrissi A. Taurine regulation of neuroendocrine function. Adv Exp Med Biol. 2019;1155:977-985. doi:10.1007/978-981-13-8023-5_81

6. Wójcik OP, Koenig KL, Zeleniuch-Jacquotte A, Costa M, Chen Y. The potential protective effects of taurine on coronary heart disease. Atherosclerosis. 2010;208(1):19. doi:10.1016/j.atherosclerosis.2009.06.002

7. Kawasaki A, Ono A, Mizuta S, Kamiya M, Takenaga T, Murakami S. The taurine content of Japanese seaweed. Adv Exp Med Biol. 2017;975 Pt 2:1105-1112. doi:10.1007/978-94024-1079-2_88

8. Wang W, Wu Z, Dai Z, Yang Y, Wang J, Wu G. Glycine metabolism in animals and humans: implications for nutrition and health. Amino Acids. 2013;45(3):463-477. doi:10.1007/s00726-013-1493-1

9. Jun H, Choi MJ. Relationship between taurine intake and cardiometabolic risk markers in Korean elderly. Adv Exp Med Biol. 2019;1155:301-311. doi:10.1007/978-981-13-80235_29

10. Alves A, Bassot A, Bulteau AL, Pirola L, Morio B. Glycine metabolism and its alterations in obesity and metabolic diseases. Nutrients. 2019;11(6):1356. doi:10.3390/nu11061356

11. Tan HC, Hsu JW, Tai ES, et al. De novo glycine synthesis is reduced in adults with morbid obesity and increases following bariatric surgery. Front Endocrinol. 2022;13:900343. doi:10.3389/fendo.2022.900343

12. Imae M, Asano T, Murakami S. Potential role of taurine in the prevention of diabetes and metabolic syndrome. Amino Acids. 2014;46(1):81-88. doi:10.1007/s00726-012-1434-4

13. Tao X, Zhang Z, Yang Z, Rao B. The effects of taurine supplementation on diabetes mellitus in humans: a systematic review and meta-analysis. Food Chem Mol Sci. 2022;4:100106. doi:10.1016/j.fochms.2022.100106

14. Guan L, Miao P. The effects of taurine supplementation on obesity, blood pressure and lipid profile: a meta-analysis of randomized controlled trials. Eur J Pharmacol. 2020;885:173533. doi:10.1016/j.ejphar.2020.173533

15. Yamori Y, Taguchi T, Mori H, Mori M. Low cardiovascular risks in the middle aged males and females excreting greater 24-hour urinary taurine and magnesium in 41 WHO-CARDIAC study populations in the world. J Biomed Sci. 2010;17(Suppl 1):S21. doi:10.1186/1423-0127-17-S1-S21

16. Santulli G, Kansakar U, Varzideh F, Mone P, Jankauskas SS, Lombardi A. Functional role of taurine in aging and cardiovascular health: an updated overview. Nutrients. 2023;15(19):4236. doi:10.3390/nu15194236

17. Waldron M, Patterson SD, Tallent J, Jeffries O. The effects of oral taurine on resting blood

*An IPSOS 2023 survey among US functional medicine practitioners, in an average month, Designs for Health is their personally most trusted practitioner supplement brand, meaning a brand that is sold by healthcare practitioners in their office.

pressure in humans: a meta-analysis. Curr Hypertens Rep. 2018;20(9):81. doi:10.1007/ s11906-018-0881-z

18. Guizoni DM, Vettorazzi JF, Carneiro EM, Davel AP. Modulation of endothelium-derived nitric oxide production and activity by taurine and taurine-conjugated bile acids. Nitric Oxide Biol Chem. 2020;94:48-53. doi:10.1016/j.niox.2019.10.008

19. Chen W, Guo J, Zhang Y, Zhang J. The beneficial effects of taurine in preventing metabolic syndrome. Food Funct. 2016;7(4):1849-1863. doi:10.1039/c5fo01295c

20. Abud GF, De Carvalho FG, Batitucci G, et al. Taurine as a possible antiaging therapy: a controlled clinical trial on taurine antioxidant activity in women ages 55 to 70. Nutrition. 2022;101:111706. doi:10.1016/j.nut.2022.111706

21. Ito T, Schaffer SW, Azuma J. The potential usefulness of taurine on diabetes mellitus and its complications. Amino Acids. 2012;42(5):1529-1539. doi:10.1007/s00726-011-0883-5

22. Cruz M, Maldonado-Bernal C, Mondragón-Gonzalez R, et al. Glycine treatment decreases proinflammatory cytokines and increases interferon-γ in patients with type 2 diabetes. J Endocrinol Invest. 2008;31(8):694-699. doi:10.1007/BF03346417

23. Xu FL, You HB, Li XH, Chen XF, Liu ZJ, Gong JP. Glycine attenuates endotoxininduced liver injury by downregulating TLR4 signaling in Kupffer cells. Am J Surg. 2008;196(1):139-148. doi:10.1016/j.amjsurg.2007.09.045

24. Kumar P, Liu C, Hsu JW, et al. Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: results of a pilot clinical trial. Clin Transl Med. 2021;11(3):e372. doi:10.1002/ctm2.372

25. Kawai N, Sakai N, Okuro M, et al. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. Neuropsychopharmacology. 2015;40(6):1405-1416. doi:10.1038/npp.2014.326

26. Inagawa K, Hiraoka T, Kohda T, Yamadera W, Takahashi M. Subjective effects of glycine ingestion before bedtime on sleep quality. Sleep Biol Rhythms. 2006;4(1):75-77. doi:10.1111/j.1479-8425.2006.00193.x

27. Yamadera W, Inagawa K, Chiba S, Bannai M, Takahashi M, Nakayama K. Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep Biol Rhythms. 2007;5(2):126-131. doi:10.1111/j.14798425.2007.00262.x

28. Wu M, Cronin K, Crane JS. Biochemistry, collagen synthesis. In: StatPearls. StatPearls Publishing; 2024. Accessed October 1, 2024. http://www.ncbi.nlm.nih.gov/books/ NBK507709/

29. Praet SFE, Purdam CR, Welvaert M, et al. Oral supplementation of specific collagen peptides combined with calf-strengthening exercises enhances function and reduces pain in Achilles tendinopathy patients. Nutrients. 2019;11(1):76. doi:10.3390/nu11010076

30. de Paz-Lugo P, Lupiáñez JA, Meléndez-Hevia E. High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis. Amino Acids. 2018;50(10):1357-1365. doi:10.1007/ s00726-018-2611-x

31. Hashizume O, Ohnishi S, Mito T, et al. Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects. Sci Rep. 2015;5(1):10434. doi:10.1038/srep10434

Effects and benefits include:

• Reduction in Apolipoprotein B (ApoB) levels

• Reduction in lipids and improving cardiovascular parameters

• Regulating sleep patterns while increasing SIRT1 expression, mimicking the benefits of regular exercise

Reducing Cardiovascular Disease Risk Without Statins

By: Leonard Pastrana, PharmD

Claiming roughly 17.9 million lives each year, Cardiovascular Diseases (CVDs) are the leading causes of death globally according to the World Health Organization (WHO). Preventative measures can start as early as in our 20s by identifying and improving behavior patterns in exercise, proper weight management, and balanced diets, delaying our chances of CVD-related health concerns and events. While statins have long proven their ability to manage cardiovascular disease risk and atherogenic lipid levels, GLP-1 dual agonists in combination with natural compounds offer a promising strategy without the use of statins and their potential long-term side effects. This article explores how the synergy of these interventions can optimize cardiovascular health.

GLP-1 Dual Agonists and Their Impact

Tirzepatide, a dual GLP-1 agonist, plays a crucial role in enhancing the lipid-buffering capacity of white adipose tissue (WAT). By preventing lipid spillover and ectopic fat accumulation, Tirzepatide and other

known GLP-1 dual agonists address key factors that contribute to an individual’s cardiovascular risk profile by reducing blood pressure, LDL, total triglycerides, and body weight in obese patients. This action helps improve both glucose metabolism and lipid management, reducing the risk of cardiovascular complications. In fact, a recent JAMA study found that GLP-1 dual agonists reduced the risk of stroke, heart attacks, and death from cardiovascular causes by 20% compared to placebo in Type 2 Diabetes patients, making these biomarkers highly effective in identifying an individual’s risk of a cardiovascular event long before the age of traditional detection.

“GLP-1 dual agonists play a crucial role in enhancing the lipid-buffering capacity of white adipose tissue… improving both glucose metabolism and lipid management, reducing [a patient’s overall] risk of cardiovascular complications.”

Reducing Cardiovascular Disease Risk Without

The Role of Polymethoxylated Flavones

Polymethoxylated flavones, found in citrus peels and other plant sources, offer significant anti-inflammatory and lipidlowering benefits. Nobiletin, a citrus-derived flavonoid, has been shown to increase hepatic fatty acid oxidation, decrease fatty acid synthesis, decrease inflammatory gene transcription factors, and enhance circadian rhythms that protect against metabolic syndrome. Additionally, these compounds enhance endothelial function and reduce oxidative stress, complementing the effects of GLP-1 dual agonists in managing cardiovascular risk. When used together, they can provide a robust defense against the progression of atherosclerosis and other plaque-causing blockages affecting blood flow within the body.

The Role of Tocotrienols

Tocotrienols, a subgroup of vitamin E, provide a unique approach to cholesterol management and cardiovascular health by targeting HMG-CoA reductase through a dual mechanism, similar to the performance of statins. However, unlike statins, which competitively inhibit the enzyme and can lead to adverse effects like muscle pain and increased diabetes risk, tocotrienols work at the post-transcriptional level to decrease the enzyme’s production while simultaneously enhancing its degradation through the farnesylation pathway. This dual action not only lowers LDL cholesterol and total cholesterol but also reduces oxidative stress

and inflammation, offering cardioprotective benefits without the potential risks associated with statin use.

In addition to these lipid-lowering effects, tocotrienols improve arterial health by modulating inflammatory pathways, reducing C-reactive protein (CRP) levels, and enhancing endothelial function. This makes tocotrienols an ideal component of cardiovascular management, particularly for individuals seeking statin alternatives.

Sytrinol and the Powerful Effects of Merging Tocotrienols and Polymethoxylated Flavones

Sytrinol, a patented combination of polymethoxylated flavones and tocotrienols, has been shown to reduce lipids and improve cardiovascular parameters across all groups in human trials when tested over placebo. Most importantly, significant reductions were shown in apolipoprotein B (ApoB) levels, which are the biggest indicators of atherosclerotic plaque and a leading measure for the precise count of atherogenic lipoprotein particles (VLDL, LDL, IDL) in individuals. In addition to Sytrinol’s effects on ApoB and lipid reduction, both Sytrinol and Nobiletin, have been shown to regulate sleep patterns while increasing SIRT1 expression, mimicking the benefits of regular exercise.

Synergistic Effects of Leucine and Nicotinic Acid

Recent studies have demonstrated that combining leucine (L) with low doses of nicotinic acid (NA) can significantly reduce atherogenesis. This combination activates the AMPK/Sirt1 signaling pathway, the same pathway activated by exercise, which is crucial for regulating lipid metabolism. By enhancing fat oxidation and improving lipid profiles, leucine amplifies the lipid-lowering effects of NA, offering a potential therapeutic

alternative to high-dose nicotinic acid, which is often poorly tolerated due to side effects. This synergy targets lipid accumulation and inflammation, both key factors in the progression of cardiovascular diseases.

“This combination [Leucine and Nicotinic Acid] activates the AMPK/Sirt1 signaling pathway, crucial for regulating lipid metabolism and inflammation.”

Exercise: The Natural Modulator

Regular exercise remains a cornerstone in managing cardiovascular risks. It improves endothelial function, boosts antioxidant defenses, and reduces inflammatory markers, helping to stabilize atherosclerotic plaques. In addition to the cardiovascular benefits, maintaining muscle mass through resistance training is essential in prolonging an individual’s overall health and longevity. For those unable to engage in sufficient physical activity, exercise mimetic compounds can replicate these effects by activating the same signaling pathways, making it possible to maintain cardiovascular health through alternative means. While the best results would be to

Author Bio:

Leonard Pastrana, PHARMD leonard@nubioage.com 561-223-8174

References:

https://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1

Chou R, Cantor A, Dana T, et al. Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA. 2022;328(8):754–771. doi:10.1001/jama.2022.12138

Chuang M, Chen J, Wang H, Jiang Z, Wu V. Clinical Outcomes of Tirzepatide or GLP-1 Receptor Agonists in Individuals With Type 2 Diabetes. JAMA Netw Open. 2024;7(8):e2427258. doi:10.1001/jamanetworkopen.2024.27258

Ramanathan N, Tan E, Loh LJ, Soh BS, Yap WN. Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities. Nutr Metab (Lond). 2018 Jan 19;15:6. doi: 10.1186/s12986-018-0244-4. PMID: 29387138; PMCID: PMC5775572.

Matsuzaki K, Ohizumi Y. Beneficial Effects of Citrus-Derived Polymethoxylated Flavones for Central Nervous System Disorders. Nutrients. 2021 Jan 4;13(1):145. doi: 10.3390/nu13010145. PMID: 33406641; PMCID: PMC7824236.

Kim YJ, Choi MS, Woo JT, Jeong MJ, Kim SR, Jung UJ. Long-term dietary supplementation

use a combination of both regular physical exercise and exercise-mimetic compounds for maintaining a healthy weight and sufficient muscle mass, the use of GLP-1 dual agonists and Sytrinol can support cardiovascular health and minimize the risks of cardiovascular events.

Conclusion

The goal is simple, to minimize cardiovascular risk an individual needs to maintain a healthy weight, reduce blood pressure, and minimize atherosclerotic plaque. While statins are effective in reducing the risk of cardiovascular diseases, combining GLP-1 dual agonists with natural compounds like polymethoxylated flavones and the synergistic effects of leucine and nicotinic acid, alongside regular exercise and/or mimetic alternatives, provides a comprehensive approach to managing cardiovascular disease risk. By targeting multiple pathways involved in lipid metabolism and inflammation, this strategy offers a powerful means to optimize heart health and reduce atherogenic lipid levels. When all converge, they impact the same pathways that statins target without the potential downfalls of using statin drugs, making them a viable and proven option for preventing cardiovascular risks.

Dr. Leonard Pastrana, pharmacist, speaker, and co-founder of nuBioAge and nuHx, is a leader in cellular medicine integration. Creator of nuCleus™, he champions peptide-enhancing supplements and protocols, advancing longevity medicine in mainstream healthcare for transformative patient outcomes.

with low-dose nobiletin ameliorates hepatic steatosis, insulin resistance, and inflammation without altering fat mass in diet-induced obesity. Mol Nutr Food Res. 2017 Aug;61(8). doi: 10.1002/mnfr.201600889. Epub 2017 Mar 2. PMID: 28116779.

He B, Nohara K, Park N, Park YS, Guillory B, Zhao Z, Garcia JM, Koike N, Lee CC, Takahashi JS, Yoo SH, Chen Z. The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. Cell Metab. 2016 Apr 12;23(4):610-21. doi: 10.1016/j.cmet.2016.03.007. PMID: 27076076; PMCID: PMC4832569.

Zemel MB. Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span. J Med Food. 2020 Nov;23(11):1129-1135. doi: 10.1089/jmf.2020.0105. Epub 2020 Aug 4. PMID: 32758058.

Bruckbauer A, Banerjee J, Cao Q, Cui X, Jing J, Zha L, Li F, Xue B, Shi H, Zemel MB. Leucinenicotinic acid synergy stimulates AMPK/Sirt1 signaling and regulates lipid metabolism and lifespan in Caenorhabditis elegans, and hyperlipidemia and atherosclerosis in mice. Am J Cardiovasc Dis. 2017 Apr 15;7(2):33-47. Erratum in: Am J Cardiovasc Dis. 2017 Jul 25;7(4):97. PMID: 28533928; PMCID: PMC5435603.

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The Potential of Topical NAD+ as an Anti-Aging Skin Treatment

By: Christopher Lorich

The Potential of Topical NAD+ as an Anti-Aging Skin Treatment

By: Christopher Lorich, PharmD

The expanded list of twelve hallmarks of aging proposed in 2023 by C. López-Otín et al provides a common framework for the discussion of potential anti-aging therapies. These hallmarks include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis 1. While no single therapy will be able to target all twelve hallmarks of aging, nicotinamide adenine dinucleotide (NAD+) offers an opportunity to target as many as six of them.

NAD+ Background

NAD+ is a critical cellular enzyme with a very broad impact on multiple cellular process, including glycolysis, fatty acid oxidation, oxidative phosphorylation, and the TCA cycle 2. It plays significant roles in DNA repair, gene expression, cell death, aging, and the response to oxidative stress 3. It

is well known from introductory biology classes as the partner to NADH in oxidative phosphorylation. It is also the only precursor of NADPH, the phosphorylated version, which is used as a reducing agent in all living things for processes including the Calvin cycle, lipid synthesis, and nucleic acid synthesis 4. Additionally, based on the reversible reaction NADH + NADP+ « NAD+ + NADPH 5, it is involved in cytochrome P450 reactions, nitric oxide synthase reactions, and the recycling of glutathione disulfide back to glutathione 6

Because skin is visible, it is an area where hallmarks of aging will be most readily recognized 6. The aging process in skin involves both biological and morphological changes that can be divided into two broad categories: natural aging and photoaging 6. Natural or chronological aging results from internal changes in body function and structure. Photoaging is caused by changes in the skin because of exposure to ultraviolet light 7. Naturally aged skin typically is dry, thin, and

The Potential of Topical NAD+ as an Anti-Aging Skin Treatment

contains fine wrinkles. Photoaged skin is leathery with coarse wrinkles and shows signs of telangiectasia and uneven pigmentation. While the two types of aging have distinct clinical features, many of the underlying chemical and biological features are similar 8, focused around damage to the extracellular matrix and DNA repair.

NAD+ Effects on the Extracellular Matrix

Connective tissues in the dermis are vital to skin function. They form a support mechanism primarily composed of type I collagen fibrils 9. In comparison with young skin, collagen fibrils in aged dermis are fragmented, disorganized, and sparse; fragmented collagen is 4.3 times greater in skin greater than eighty years old compared to skin twenty-one to thirty years old 9. This fragmentation effects both the function of individual cells in the skin and the mechanical structure of the overall tissue 10 Normal collagen remodeling is primarily managed by matrix metalloproteinases (MMPs); MMP-1 expression is increased in response to oxidative stress and is found in higher concentrations in aged skin compared to young skin 9. NAD+ was shown to reduce the expression of MMP-1 and MMP-3 that is triggered by the inflammatory cytokine interleukin-1 alpha 11. This effect does not appear to be through the MAP kinase of NF-kB pathways; it is thought to be a direct effect of NAD+ or the NAD+-glycohydrolase byproduct of NAD+ which is causing the MMP inhibition 11 .

NAD+ and Oxidative Stress

NAD+ plays an important role in the cellular response to oxidative stress from reactive oxygen species such as superoxide anions, hydroxyl radicals, and hydrogen peroxide 12. When oxidative DNA damage occurs, the DNA repair enzyme poly(ADP-ribose) polymerase-1 (PARP) is activated and large quantities of NAD+ are consumed. When damage is mild to moderate, the supply of NAD+ is sufficient to supply PARP activity, but excessive DNA damage, such as prolonged exposure to sunlight, can lead to an energy crisis in the cell due to the insufficient supply of NAD+ 12

NAD+ and DNA Modulation

NAD+ is also an important regulator of the sirtuin

(SIRT) family of enzymes. These enzymes participate in the in the deacetylation of DNA to modulate key transcription factors. In both humans and mice, SIRT1 is thought to promote cell longevity through deactivation of the p53 proapoptotic gene 12. Based on studies in aged Wistar rats, Massudi et al showed that markers for oxidative stress increased with age in human skin tissue, correlating with an increase in PARP activity, NAD+ depletion, and reduced SIRT1 activity 12

NAD+ Supplement Routes and Forms

NAD+ is a very common supplement used in the antiaging industry. Though intravenous injection and oral tablets or capsules are the most common, other routes such as intranasal sprays and topical creams have come to the market. Oral supplements are the most convenient for patients but suffer from poor bioavailability due to their destruction during transit of the digestive system 13. Thus, oral administration often takes the form of NAD+ precursors such as nicotinamide mononucleotide and niacinamide 14. The major benefit of injectable and intranasal forms is that they bypass the problems of the GI tract. Unfortunately, due to the large and hydrophilic nature of the NAD+ molecule, only very small quantities cross the cell membrane as NAD+ where they could preserve or replenish intracellular stores 15. The vast majority injected NAD+ is enzymatically broken down into its precursors, which are subsequently taken into cells to participate in the endogenous NAD+ synthesis process 15

For the purposes of treating skin to improve or ameliorate the hallmarks of aging, topical application of NAD+ is a promising delivery mechanism. Like the injectable and intranasal forms, it avoids the problems of the gastrointestinal tract. Like oral administration, it is very convenient for the patient to self-administer at home. While the minimal direct cellular uptake of NAD+ is a common problem to all delivery routes, it is important to note that the inhibition of MMPs occurs primarily in the extracellular matrix, meaning topical application may provide the most efficient delivery of NAD+ for this purpose. For other mechanisms of action within the cells, topical application may provide a way to directly target the skin while reducing the side effects of systemic administration.

Due to the unstable nature of NAD+ in topical formulations, there is very little peer-reviewed data for this delivery route and further study is needed. One study suggests that refrigeration at 5˚C was sufficient to extend NAD+ ointment stability to ten months with only 20% loss of potency 16, with very good results in the three to six month period. While that study was focused on treatment of psoriasis, it is notable that subjects reported greater

cosmetic acceptability of the NAD+ ointment compared to other topical agents in the study. Anecdotal evidence suggests that there is a burgeoning market of patients experiencing positive results already using topical NAD+ for its anti-aging benefits. NAD+ holds a lot of promise as an addition to any anti-aging skin treatment plan.

Author Bio:

Christopher Lorich is a sterile production pharmacist for Olympia Pharmaceuticals. He graduated cum laude from the University of Florida in 2023 following a prior career as a chemistry and physics teacher.

References:

1. López-Otín C, Blasco M, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding Universe. Cell. Jan 2023;186(2):243-278.

2. Cantó C, Auwerx J. NAD+ as a signaling molecule modulating metabolism. Cold Spring Harb Symp Quant Biol. Feb 2011;76(1):291-298.

3. Amad S, Nisar S, Bhat AA, et al. Role of NAD+ in regulating cellular and metabolic signaling pathways. Mol Metab. Feb 2021;49.

4. Spaans S, Weusthuis R, van der Oost J, Kengen S. NADPH-generating systems in bacteria and archea. Front Microbiol. July 2015;742.

5. Zhang Q, Padayatti P, Leung J. Proton-translocating nicotinamide nucleatodie transhydrogenase: A structural perspective. Front Physiol. Dec 2017;8(1089).

6. Boo YC. Mechanistic basis and clinical evidence for the applications of nicotinamide (niacinamide) to control skin aging and pigmentation. Antioxidants. August 2021;10(1315).

7. Fisher G, Kang S, Varani J, et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 2002;138(11):1462-1470.

8. Rittié L, Fisher G. Natural and sun-induced aging of human skin. Cold Spring Harb Perspect Med. Jan 2015;5(1):1-14.

9. Fisher G, Quan T, Puronit T, et al. Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin. Am J Pathol. Jan 2009;174(1):101-114.

10. West M. The cellular and molecular biology of skin aging. Arch Dermatol. Jan 1994;130(1):87-95.

11. Gotoh K, Nemoto E, Kanaya S, Shimauchi H. Extracellular ?-NAD(+) inhibits interleukin-1-induced matrix metalloproteinase-1 and -3 expression on human gingival fibroblasts. Connect Tissue Rejs. March 2013;54(3):204-209.

12. Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, Guillemin GJ. Ageassociated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS ONE. July 2012;7(7):e42357.

13. She J, Sheng R, Qin Z. Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors. Aging Dis. December 2021;12(8):1879-1897.

14. Okabe K, Yaku K, Uchida Y, et al. Oral administration of nicotinamide mononucleotide is safe and efficienty increases blood nicotinamide adenine dinucleotide levels in healthy subjects. Front Nutr. April 2022;11(9).

15. Billington RA, Travelli C, Ercolano E, et al. Characterization of NAD uptake in mammalian cells. Journal of Biological Chemistry. March 2008;283(10):63676374.

16. Wozniacka A, Szajerski P, Adamus J, Gebicki J, Sysa-Jedrzejowska A. In search for new antipsoriatic agents: NAD+ topical composition. Skin Pharmacology and Physiology. 2007;20:37-42.

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Nitric Oxide –Master Hormone And Holy Grail

Of Longevity And Anti-Aging

By: Nathan S. Bryan, PhD

The field of Longevity is exploding. People are taking action to improve their health so they can live longer and better lives free of disease. Biohacking is implementing diet and lifestyle to re-program our cells to improve their efficiency and function

so we can improve our performance at all levels. There are a number of scientifically and clinically proven modalities in the biohacking and longevity fields. However, there is one consideration that is foundational for optimal health and longevity. If

not functional, nothing else will work. If functional, everything else works better. That consideration is NITRIC OXIDE, a hormone that must be replaced as we age.

NITRIC OXIDE IS THE MASTER HORMONE

Most Americans know the importance of hormones. In fact, there is a huge industry of hormone replacement clinics around the world. Everybody knows the older we get, the less our body produces natural hormones including testosterone in men and estrogen in women. The time the body stops making these hormones is called andropause in men and menopause in women. There are amazing health benefits of hormone replacement when done correctly. There are many other important hormones that we should also consider such as thyroid hormone, cortisol, and many others. Most people do not think of nitric oxide as a hormone but back in 2007, my lab was the first to demonstrate that nitric oxide acted as a hormone. Hormones are chemical substances that act like messenger molecules in the body. After being made in one part of the body, they travel to other parts of the body to affect specific activities. Prior to our study in 2007 it was thought that nitric oxide could only act in the cell in which it was produced (autocrine) or a neighboring cell (paracrine). Our seminal paper showed that nitric oxide produced in a single organ or compartment had systemic effects that could signal and protect all other organs. This was a game changer in nitric oxide biochemistry and physiology. But the question was how could it do this since nitric oxide, once produced, is gone is less than one second. The answer is in the more stable metabolites it forms once produced in the body. Nitric oxide is converted to nitrite and also binds to glutathione once

produced to form a molecule called S-nitrosoglutatione. These two molecules extend the biological half-life of nitric oxide from 1 millisecond out to tens of minutes and hours. This allows nitric oxide to affect many other organs systemically and act as a hormone. The original discovery of nitric oxide was as a signaling molecule that led to a Nobel Prize in 1998. However, it wasn’t until our 2007 publication which revealed that nitric oxide is a hormone signaling molecule capable of affecting every organ, tissue and cell in the body when produce anywhere in the body.

THE ENDOTHELIUM, OUR LARGEST ORGAN AND ENDOCRINE GLAND

The inner most lining of cells in our blood vessels is called the endothelium. The endothelium is our largest organ and the main site of nitric oxide production, making it also an endocrine gland that secretes NO gas upon stimulation. Every organ in the body is controlled by its own blood supply. The blood supply to every organ is regulated by the function of its own endothelial cells and its ability to produce nitric oxide. We’ve known for centuries now that every major chronic disease is characterized by a diminished blood supply and reduced circulation to that organ. We see it in Alzheimers’ Disease, heart disease, kidney disease, lung disease, gastrointestinal disease and others. Without sufficient circulation, oxygen and nutrients cannot be delivered to these organs and they begin to fail. There is increased inflammation, oxidative stress and immune dysfunction that results from decreased blood flow and decreased nitric oxide production. Similar

to decreased testosterone production in the testes of men or decreased estrogen production in the ovaries in women, if there is decreased nitric oxide production in the endothelium, we get symptoms and the onset of many diseases. Also similarly, if we replace missing hormones and restore the body’s normal production, we can reverse many symptoms and actually stop the progression of disease. That has been my objective and strategy for the past 20 years. We must replace and restore nitric oxide production in order to combat the effects of aging and age-related diseases. The question has been, how do we do that safely and effectively?

PROVIDE THE BODY WITH NITRIC OXIDE

Based on our 2007 study in the Proceedings of the National Academy of Sciences, we proved that all we had to do was generate nitric oxide in a single biological compartment and then the hormone effects would take effect. When we replace other hormones such as insulin, testosterone, estrogen or thyroid, we don’t have to give testosterone shots in the testes for it to work. We don’t have to inject insulin into the pancreas and we do not have to inject estrogen into the ovaries for it to work. We can give it in the muscle, in the subcutaneous space or apply topically and then the hormone will do its job. Similarly, we don’t have to produce nitric oxide in the endothelium, we can produce it anywhere in the body and it will have its effects. That is why I chose the mouth or oral cavity as a compartment to generate nitric oxide gas. I was the first and only person in the world to produce a solid dose form of nitric oxide gas. The basis is that an orally disintegrating lozenge would slowly dissolve in the mouth and as it is dissolving active ingredients would come together to produce nitric oxide gas. Once we do that, the nitric oxide and signaling molecules produced from NO gas go systemic and nitric oxide provides its hormone function. The health benefits are measurable and profound. We get better circulation, better oxygen delivery, better stem cell function, reduced inflammation, reduced oxidative stress and better immune function. It basically reverses all of the known causes and consequences of all major chronic diseases.

HOW DO WE REPLACE NITRIC OXIDE HORMONE?

There are hundreds of so-called nitric oxide products on the market. Nearly all of them provide no therapeutic benefits since they do not produce nitric oxide themselves. Most of those products are providing pre-cursors and hoping that when consumed, the human body can produce nitric oxide from it. However, the fundamental basis for nitric oxide deficiency in patients is that they have lost the ability to utilize those pre-cursors to produce nitric oxide. The basis of my product technology that I termed “NITRICEUTICALS” actually produce nitric oxide gas. If your body can’t make nitric oxide, my products do it for you. This is only achieved through an orally disintegrating tablet or through our fermented beet powder that produces nitric oxide gas when placed in water. This cannot be achieved through capsules, gummies, chews that many other companies are selling. If you want the benefits of nitric oxide, then you must find a product that produces it for you. If your body cannot make nitric oxide, then my product technology does it for you. It is that simple. Remember the quote by Stephen Hawking “The greatest enemy of knowledge is not ignorance, it is the illusion of knowledge.” Many companies out there have an illusion of knowledge and yet others deliberately try to deceive their customers. Ignorance is curable through education and the correct information. That is my goal to educate and inform you so you can make informed decisions on what is best for your health and the health of your family. After all, there is nothing more important than our own health.

Dr. Nathan S. Bryan is a biochemist and physiologist that has more than 20 years of basic science and clinical research. His many seminal discoveries have resulted in dozens of issued U.S. and International patents. He is an international expert in nitric oxide and molecular medicine.

Instagram @drnathansbryan

LinkedIn @drnathansbryan

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www.drnathansbryan.com

Dr. Bryan is an innovator and successful entrepreneur who product technology is responsible for hundreds of millions of dollars in revenue worldwide. This content is not intended to replace medical advice from a physician.

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Organic Acids, Cognitive Function, and Brain Health

By: Christina O’Brien, DC, RDN, DACNB, IFMCP

Organic acids are pivotal in the vast landscape of metabolic processes, serving as intermediates in the degradation of proteins, fats, and carbohydrates. These compounds, often measured through urine organic acid tests, provide a snapshot of an individual’s metabolic state, offering insights into various physiological and pathological conditions. This biochemical data is not only important for understanding general health but also plays a significant role in assessing cognitive function and brain health.

The brain, a highly metabolically active organ, requires a constant and efficient supply of nutrients and the rapid removal of waste products to maintain its function. Organic acids are at the heart of this metabolic flux, influencing everything from energy production to the synthesis and breakdown of neurotransmitters. Neurotransmitters such as serotonin, dopamine, and norepinephrine, regulated by organic acid pathways, are essential for mood regulation, alertness, and cognitive capabilities.

Moreover, the balance of these neurotransmitters is tightly regulated by methylation processes, which involve the transfer of methyl groups to and from molecules, a critical epigenetic signaling tool that governs the expression of genes and the function of proteins. Imbalances in methylation, such as undermethylation or overmethylation, can lead to altered levels of neurotransmitters like serotonin, manifesting in varied cognitive and emotional disturbances.

Understanding the interplay between organic acids and brain function not only enhances our grasp of cognitive health but also directs us toward potential interventions that could mitigate the risks or progression of cognitive impairments. As we delve into the roles of specific organic acids, their pathways, and their impact on neurotransmitter levels, we unveil potential strategies to harness this knowledge for better mental health outcomes and disease prevention.

KEY ORGANIC ACIDS AND THEIR NEUROLOGICAL ROLES

GLUTATHIONE: THE MASTER ANTIOXIDANT’S ROLE IN BRAIN HEALTH AND COGNITIVE PRESERVATION

Glutathione stands out as the master antioxidant in the body, playing a pivotal role in neutralizing free radicals and maintaining the oxidative balance needed for brain health. This tripeptide, composed of glycine, cysteine, and glutamic acid, is important not only for detoxifying harmful substances but also for supporting immune function and thus, indirectly, protecting the brain. In the brain, glutathione helps to prevent the oxidative stress that can lead to neuronal damage, a key factor in cognitive decline and neurodegenerative diseases like Alzheimer’s. Furthermore, the synthesis and regulation of glutathione are influenced by genetic factors. Variations in genes responsible for synthesizing and recycling glutathione can affect an individual’s capacity to handle oxidative stress and can influence susceptibility to neurological disorders. Epigenetic mechanisms, which include DNA methylation and histone modification, also play a role in regulating these genes, highlighting the adaptive responses of cells to their changing environment and the potential for nutritional and lifestyle interventions to impact brain health through these pathways.

INDICAN: ITS LINKS TO GUT DYSBIOSIS AND SUBSEQUENT EFFECTS ON BRAIN FUNCTION

Indican, an organic acid produced as a result of tryptophan metabolism by intestinal bacteria, serves as a marker of gut dysbiosis—an imbalance in the gut microbiota. This connection is crucial, as emerging research underscores the gut-brain axis as a significant pathway through which the gastrointestinal tract influences mental and neurological health.

Increased levels of indican in the urine suggest an overgrowth of harmful bacteria in the gut that can interfere with the proper digestion and absorption of nutrients, including those necessary for neurotransmitter

synthesis. Gut dysbiosis has been linked to a variety of cognitive and behavioral issues, from decreased cognitive function to increased anxiety and depression symptoms, illustrating the gut’s role in mental health.

From an epigenetic standpoint, gut dysbiosis can influence the expression of genes involved in inflammation and immune responses, which in turn can affect brain function. The metabolites produced by gut bacteria, including indican, can act as signaling molecules that modify the epigenetic landscape, influencing gene expression in the brain. These interactions highlight the importance of maintaining gut health not only for overall wellness but also as a proactive approach to safeguard cognitive functions and mitigate neurological disorders.

THE SEROTONIN CONNECTION: METHYLATION AND MOOD REGULATION

EXPLANATION OF METHYLATION AND ITS IMPORTANCE IN NEUROTRANSMITTER SYNTHESIS

Methylation is a biochemical process involving the transfer of a methyl group (one carbon atom attached to three hydrogen atoms) onto amino acids, proteins, enzymes, and DNA in every part of the body. In the brain, methylation plays a vital role in synthesizing and breaking down neurotransmitters, which are chemical messengers that govern mood, concentration, sleep, and other cognitive functions. This process is especially important in the production and function of serotonin, a key neurotransmitter that influences mood, emotion, sleep, and appetite. Serotonin synthesis begins with the amino acid tryptophan, which is converted into 5-hydroxytryptophan (5HTP) and then into serotonin. Methylation influences this pathway by regulating the enzymes involved in converting these substances. The proper function of these enzymes ensures adequate serotonin levels and, by extension, balanced mood and cognitive function.

DISCUSSING UNDERMETHYLATION AND OVERMETHYLATION, FOCUSING ON SEROTONIN PRODUCTION

Undermethylation and overmethylation describe conditions where the body’s ability to add methyl groups to its biological molecules is compromised or excessive, respectively. Both conditions can significantly impact brain health and mood by altering neurotransmitter levels, particularly serotonin.

• Undermethylation: This condition often leads to a shortage of methyl groups necessary for the efficient production of serotonin. Individuals who are undermethylated typically have several distinct symptoms and traits, such as seasonal allergies, dry eyes, low pain tolerance, and a history of high achievement. In terms of mood, they may suffer from obsessive-compulsive disorder (OCD), oppositional defiance, and depression, all linked to insufficient serotonin activity.

• Overmethylation: Conversely, overmethylation results in an excess of methyl groups, which can lead to an overly efficient production of certain neurotransmitters, including serotonin. People who are overmethylated may exhibit symptoms such as anxiety, panic disorders, and hyperactivity. They often report food and chemical sensitivities, along with a tendency towards high anxiety, which can be related to excessive serotonin and dopamine levels.

HOW LOW SEROTONIN LEVELS

CORRELATE WITH COGNITIVE CHALLENGES AND MOOD DISORDERS

Low serotonin levels are closely tied to a variety of cognitive and mood disorders. Clinically, insufficient serotonin can manifest as depression, anxiety, sleep disturbances, and other mood disorders. This neurotransmitter is not only pivotal in regulating mood but also plays a role in cognition, influencing everything from memory to decision-making processes.

The relationship between low serotonin and cognitive disorders is also evident in conditions such as Alzheimer’s disease and Parkinson’s disease, where altered serotonin pathways are commonly observed. Studies have shown that managing serotonin levels can help mitigate symptoms and,

in some cases, slow the progression of cognitive decline.

From a broader perspective, addressing methylation imbalances can be a strategic approach to enhancing serotonin production and achieving better cognitive and emotional health. This can include dietary adjustments to increase or decrease methionine intake (a key methyl donor), supplementation with B vitamins (co-factors in methylation pathways), and lifestyle changes to reduce stress, which can negatively impact methylation balance.

OTHER ESSENTIAL NEUROTRANSMITTERS: BEYOND SEROTONIN

DOPAMINE AND NOREPINEPHRINE: THEIR PATHWAYS AND IMPACT ON COGNITION AND EMOTIONAL REGULATION

Dopamine and norepinephrine are two neurotransmitters that play pivotal roles in both the central and peripheral nervous systems. Their influence extends across a wide range of psychological functions, from emotional response to cognitive abilities like attention and decision-making.

• Dopamine: Often dubbed the ‘feel-good’ neurotransmitter, dopamine is integral in the brain’s reward system. It is produced in several areas of the brain, including the substantia nigra and the ventral tegmental area. Dopamine is not only used for experiencing pleasure and satisfaction but also plays a significant role in motor control and cognitive function. It influences focus, motivation, and memory. Disruptions in dopamine levels are linked to conditions such as Parkinson’s disease, characterized by motor control issues, and schizophrenia, noted for cognitive and emotional disturbances. Low levels of HVA, the breakdown product of dopamine, have been associated with Autism.

• Norepinephrine: This neurotransmitter is predominantly produced in the locus coeruleus, an area of the brainstem, and acts as a stress hormone and neurotransmitter. It is pivotal in the body’s fight-

or-flight response, increasing arousal and alertness, accelerating reaction time, and stimulating the release of glucose for energy. In the brain, norepinephrine enhances memory retrieval, attention to detail, and the formation of emotional memories. It is imperative for cognitive alertness and also plays a role in emotional regulation. Imbalances in norepinephrine levels, reflected by low levels of VMA, are associated with mood disorders such as depression, while high levels of VMA are associated with anxiety, as well as attention-deficit hyperactivity disorder (ADHD).

CORTISOL AND ADRENAL HORMONES: THEIR ROLE IN STRESS RESPONSE AND MENTAL CLARITY

Cortisol, often referred to as the stress hormone, is produced in the adrenal cortex under the regulation of the hypothalamic-pituitary-adrenal (HPA) axis. It has numerous functions including regulating metabolism, reducing inflammation, and controlling the sleep-wake cycle. Its most noted role, however, is in managing how the body responds to stress.

• Cortisol: In the short term, cortisol can provide a necessary boost to energy, heightened memory functions, increased immunity, and a higher pain threshold – all experienced during acute stress situations. However, prolonged elevation of cortisol levels can lead to detrimental effects such as weight gain, high blood pressure, disrupted sleep, and a compromised immune response. Chronic high cortisol can also lead to mental cloudiness and decreased cognitive performance, often referred to as ‘brain fog.’

• Adrenal Hormones: Besides cortisol, the adrenal glands produce other hormones such as adrenaline (epinephrine) and smaller amounts of sex hormones. Adrenaline, like norepinephrine, plays a significant role in the fight-or-flight response, preparing the body for quick action. In terms of cognitive function, adrenaline boosts alertness and can enhance memory consolidation; however, excessive levels can lead to anxiety and decreased concentration over time.

The balance of these neurotransmitters and hormones is necessary for optimal cognitive and emotional

health. Dysregulation can lead to a variety of cognitive deficits and emotional disorders, emphasizing the need for a balanced neurochemical environment for maintaining mental clarity and emotional stability.

NUTRITIONAL INFLUENCES ON NEUROTRANSMITTER PRODUCTION

VITAMIN B6 AND BIOTIN DEFICIENCIES: IMPACT ON NEUROTRANSMITTER SYNTHESIS

• Vitamin B6: Also known as pyridoxine, Vitamin B6 is used for the normal function of enzymes that produce neurotransmitters, including serotonin, dopamine, and gamma-aminobutyric acid (GABA). This vitamin plays a pivotal role in the decarboxylation and transamination reactions that convert amino acids into these neurotransmitters. A deficiency in Vitamin B6 can lead to decreased synthesis of these brain chemicals, which may manifest as mood disturbances, impaired cognitive function, and increased susceptibility to stress and anxiety. Moreover, Vitamin B6 is involved in the modulation of homocysteine levels, an amino acid that, at high levels, is associated with neurodegenerative diseases such as Alzheimer’s.

• Biotin: Biotin, or Vitamin B7, is another B-vitamin that impacts health, including cognitive functions, through its role in the metabolism of fats, carbohydrates, and proteins. It supports the activities of several enzymes essential for the production of energy and neurotransmitters. Biotin deficiency, though rare, can lead to neurological symptoms such as lethargy, depression, and hallucinations due to its role in synthesizing neurotransmitters that regulate mood and cognitive functions.

DIETARY SOURCES AND SUPPLEMENTS TO SUPPORT NEUROTRANSMITTER HEALTH

To prevent deficiencies and support neurotransmitter health, incorporating rich sources of Vitamin B6 and Biotin in the diet is recommended, along with considering supplementation if necessary:

• Dietary Sources of Vitamin B6: Rich sources of Vitamin B6 include poultry like chicken and turkey, fish such as salmon and tuna, and leafy green vegetables, bananas, and chickpeas. These foods can help maintain adequate levels of Vitamin B6, supporting the production of neurotransmitters and overall brain health.

• Dietary Sources of Biotin: Biotin can be found in a wide range of foods, such as organ meats (especially liver), egg yolks, nuts like almonds and peanuts, soybeans, whole grains, and mushrooms. Regular consumption of these foods can help maintain healthy biotin levels.

• Supplementation: In cases where dietary intake might not be sufficient, or for individuals with increased nutritional needs, supplements can help maintain optimal levels of these vitamins. It’s important to consult with a healthcare provider before starting any supplementation, especially since B vitamins are water-soluble and excess amounts are typically excreted in urine, although they can sometimes cause side effects at very high doses.

Additionally, lifestyle factors such as managing stress, ensuring adequate sleep, and regular physical activity can enhance the body’s ability to utilize these nutrients effectively, thereby supporting neurotransmitter synthesis and overall mental health.

COGNITIVE DISORDERS AND ORGANIC ACID DYSREGULATION

THE CONNECTION BETWEEN ORGANIC ACID IMBALANCES AND COGNITIVE DISORDERS LIKE ALZHEIMER’S

Organic acids play a role in cellular metabolism, including the brain’s energy production and detoxification processes. Imbalances in these acids can indicate or contribute to metabolic disruptions that affect brain health. One clear example is the role of mitochondrial dysfunction in neurodegenerative diseases like Alzheimer’s disease. Mitochondria, responsible for energy production, rely

heavily on the proper functioning of the Krebs cycle, where several organic acids like citric acid, alphaketoglutarate, and malic acid are key components.

Disruptions in these cycles can lead to decreased energy production and increased oxidative stress—conditions often observed in Alzheimer’s patients. Moreover, certain organic acids are directly neurotoxic if allowed to accumulate due to metabolic impairments, potentially contributing to the neuronal damage seen in cognitive disorders.

Furthermore, markers such as homocysteine, an amino acid processed in the methylation cycle, can accumulate when there are deficiencies in B vitamins (B6, B12, folate), leading to increased risk factors for Alzheimer’s disease. Elevated homocysteine levels are associated with greater neurotoxicity and higher incidences of vascular issues, which compromise blood flow to the brain and exacerbate cognitive decline.

THE ROLE OF HORMONE METABOLITES AND NEUROTRANSMITTER IMBALANCES IN DEGENERATIVE BRAIN DISEASES

Hormone metabolites also play significant roles in brain health and function. For instance, cortisol, a steroid hormone produced in the adrenal glands, helps regulate metabolism, inflammation, and response to stress. However, prolonged elevated cortisol levels can lead to neuronal damage and are associated with memory loss and decreased cognitive function seen in Alzheimer’s and other forms of dementia. Additionally, neurotransmitter imbalances are central to the pathology of degenerative brain diseases. For example, Alzheimer’s disease is characterized not only by the hallmark amyloid plaques and tau protein tangles but also by a significant decrease in acetylcholine, a neurotransmitter important for learning and memory. This decrease is partly attributed to disrupted metabolic pathways influenced by organic acid imbalances.

Neurotransmitters like serotonin and dopamine are also affected in neurodegenerative diseases, contributing to the mood and behavioral symptoms often seen in these conditions. For example, Parkinson’s disease

involves the significant depletion of dopamine due to the degeneration of dopaminergic neurons in the brain, impacting both motor and cognitive functions.

STRATEGIES FOR ADDRESSING ORGANIC ACID DYSREGULATION

To address these challenges, it’s necessary to ensure metabolic balance and support mitochondrial function through targeted nutrition, supplementation, and lifestyle changes. Diets rich in antioxidants, essential fats, and adequate proteins can support mitochondrial health and reduce oxidative stress. Supplements like Coenzyme Q10, alpha-lipoic acid, and N-acetyl cysteine may help improve mitochondrial function and overall metabolic health. Regular physical activity and strategies to manage stress levels can also significantly impact hormone balance and neurotransmitter production, supporting overall brain health and reducing the risk of cognitive decline.

ADDRESSING FATIGUE AND COGNITIVE DECLINE

THE INTERPLAY BETWEEN FATIGUE, HORMONE LEVELS, AND COGNITIVE FUNCTION

Fatigue, a common complaint in both clinical and everyday settings, is often more than just a symptom of poor sleep; it can be deeply intertwined with hormonal imbalances and cognitive decline. Hormones such as cortisol, thyroid hormones, and sex hormones (estrogen, progesterone, and testosterone) play significant roles in regulating energy levels, mood, and cognitive functions.

• Cortisol: Known as the “stress hormone,” cortisol has a natural rhythm — high in the morning to promote wakefulness and declining throughout the day. Disruptions in this rhythm, whether due to stress, poor sleep, or adrenal dysfunction, can lead to persistent fatigue and reduced cognitive capabilities, such as decreased concentration and memory.

• Thyroid Hormones: These are imperative for metabolism regulation. Hypothyroidism, or low thyroid hormone levels, can manifest as

fatigue, sluggishness, and cognitive slowing, severely impacting daily functioning.

• Sex Hormones: Estrogen and testosterone influence energy levels and brain function. Estrogen enhances serotonin and norepinephrine, impacting mood and cognitive functions, while testosterone levels are associated with energy and motivation. Imbalances in these hormones can lead to fatigue and cognitive fog.

Moreover, neurotransmitter imbalances also play a role in the perception of fatigue. For example, low levels of dopamine can reduce motivation and drive, whereas imbalances in serotonin can affect sleep patterns and mood, contributing to fatigue.

PRACTICAL TIPS FOR MANAGING FATIGUE THROUGH HORMONAL AND NEUROTRANSMITTER BALANCE

Addressing fatigue and preventing cognitive decline require a multifaceted approach. Here are some practical strategies:

1. Regular Sleep Patterns: Ensuring consistent and quality sleep helps regulate cortisol and supports overall hormonal balance, which is crucial for reducing fatigue and maintaining cognitive functions.

2. Balanced Diet: A diet rich in antioxidants, proteins, and essential fatty acids supports neurotransmitter and hormone production. Foods high in B vitamins (like leafy greens and whole grains) and omega-3 fatty acids (such as fish and flaxseeds) can enhance energy levels and cognitive health.

3. Physical Activity: Regular exercise boosts endorphin levels, which can help combat fatigue. It also stimulates the production of more neurotransmitters, such as dopamine and serotonin, which improve mood and energy levels.

4. Stress Management: Techniques such as mindfulness, yoga, or even simple breathing exercises can reduce cortisol levels and improve both mental and physical health.

5. Supplementation: Supplements such as Vitamin D, magnesium, and adaptogenic herbs like ashwagandha

can support hormonal balance and neurotransmitter functions. It’s important to consult with a healthcare provider before starting any new supplement regimen.

6. Hydration: Adequate hydration is vital for maintaining the efficiency of metabolic processes and the transport of hormones and nutrients within the body.

7. Medical Evaluation: For persistent fatigue, a thorough evaluation by a healthcare provider can determine if underlying issues such as adrenal dysfunction or hypothyroidism are contributing factors. Approaches like DUTCH testing can be particularly insightful for understanding hormones and their metabolites.

TAKE CHARGE OF BRAIN HEALTH THROUGH TESTING

As we navigate the complexities of brain health and the intricate biochemical interactions that support it, the importance of personalized health assessments

Author Bio:

Dr. Christina O’Brien, DC, RDN, DACNB, IFMCP is a skilled and compassionate healthcare professional with years of experience in helping her patients achieve optimal health and wellness. She is a clinical educator with Precision Analytical, Inc.

References:

1. Garvey MJ, Noyes R Jr, Woodman C, Laukes C. Relationship of generalized anxiety symptoms to urinary 5-hydroxyindoleacetic acid and vanillylmandelic acid. Psychiatry Res. 1995 Jun 29;57(1):1-5. doi: 10.1016/0165-1781(94)02510p. PMID: 7568554.

2. Arias-Carrión O, Stamelou M, Murillo-Rodríguez E, Menéndez-González M, Pöppel E. Dopaminergic reward system: a short integrative review. Int Arch Med. 2010 Oct 6;3:24. doi: 10.1186/1755-7682-3-24. PMID: 20925949; PMCID: PMC2958859.

3. Ko JH, Strafella AP. Dopaminergic neurotransmission in the human brain: new lessons from perturbation and imaging. Neuroscientist. 2012 Apr;18(2):149-68. doi: 10.1177/1073858411401413. Epub 2011 May 2. PMID: 21536838; PMCID: PMC3479149.

becomes undeniable. Understanding your unique metabolic, hormonal, and neurotransmitter profiles is not just about identifying problems—it’s about forging pathways to optimal health and wellness.

Tools like the DUTCH Test, which provides detailed insights into sex and adrenal hormones, their metabolites, and organic acids, offer more than just data; they offer a blueprint for health interventions that are as unique as you are. These tests can reveal imbalances that may not yet manifest as symptoms but could be silently impacting your cognitive function and overall well-being.

By testing, you empower yourself not only to understand the current state of your health but also to take effective, personalized actions that enhance your brain function and overall vitality. Don’t wait for symptoms to dictate your health strategy. Be proactive and take control of your health journey today.

Contact number: 503-687-2050

Email address: marketing@dutchtest.com

4. Marsden CA. Dopamine: the rewarding years. Br J Pharmacol. 2006 Jan;147 Suppl 1(Suppl 1):S136-44. doi: 10.1038/sj.bjp.0706473. Erratum in: Br J Pharmacol. 2021 Dec;178(23):4772. PMID: 16402097; PMCID: PMC1760752.

5. Kałuzna-Czaplińska J, Socha E, Rynkowski J. Determination of homovanillic acid and vanillylmandelic acid in urine of autistic children by gas chromatography/mass spectrometry. Med Sci Monit. 2010 Sep;16(9):CR445-50. PMID: 20802418.

6. Gutierrez L, Folch A, Rojas M, Cantero JL, Atienza M, Folch J, Camins A, Ruiz A, Papandreou C, Bulló M. Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials. Nutrients. 2021 Oct 22;13(11):3728. doi: 10.3390/ nu13113728. PMID: 34835984; PMCID: PMC8621754.

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Collagen & Silicon Key Elements for Connective Tissue Health

Author: Dr. Arland Hill, DC, MPH, DACBN Director of Clinical Education for Biotics Research ®

In the realm of healthcare, particularly for chiropractors, it is paramount to understand the crucial role of connective tissue health, and why supplementing with collagen has become so popular. Central to this understanding are two crucial components: collagen and silicon, both integral in maintaining and enhancing the structural integrity of various body tissues.1

Collagen, the most abundant protein in the human body, constitutes a major part of the extracellular matrix. It is a foundational structural element in bones, tendons, ligaments, hair, skin, cartilage, intervertebral discs, muscles, and even blood vessels. Although there are 28 distinct types of collagen, types I, II, and III account for 80-90% of the body’s total collagen. These types are critical for providing mechanical resilience and support for cell growth. Since age-related decline in collagen synthesis contributes to changes in skin, joints, and other connective tissues, the case for supplementing with collagen has grown stronger in recent years.2

Supplementation with collagen peptides has been shown to support connective tissues in several clinical studies. Benefits include improvements to skin hydration, elasticity, and wrinkling.3 Potential mechanisms include stimulation of collagen and proteoglycans in the skin, as well as enhanced skin turnover.4 It has even been found to improve scores related to mental and social health in a randomized controlled trial of middle-aged participants.5

Silicon is an abundant trace element in the body and a key component of the extracellular matrix, particularly in the bone, skin, and hair.6 It aids in the synthesis of collagen and acts as a cross-linking agent between collagen and proteoglycans. Mesoporosil®, a unique bioavailable form of silicon, has been shown in vitro to stimulate the synthesis of type I collagen and to promote osteoblast function, including the enhancement of bone mineralization.

The constructive interaction between collagen and silicon is noteworthy. Collagen provides the necessary framework for connective tissues, while silicon enhances this framework, contributing to the strength and resilience of these tissues.

Optimal Collagen, recently launched by Biotics Research, delivers a comprehensive collagen profile, focusing on types I, II, and III, and is enriched with Mesoporosil®, enhancing the benefits of collagen and supporting multiple tissues, including joints, bone, and skin. The hydrolyzed collagen found in Optimal Collagen is comprised of low molecular weight bioactive collagen peptides, demonstrating high bioavailability. Many clinical benefits of hydrolyzed collagen indicate that these peptides accumulate in the cartilage, stimulating chondrocytes and stimulating osteoblast activity.7 Optimal Collagen also provides eggshell membrane and sternum collagen, rich in collagen type II, as well as types I, V, X, along with chondroitin sulfate and hyaluronic acid.

For more information on Optimal Collagen visit the Biotics Research® website at www.bioticsresearch.com

REFERENCES:

1. Ouyang, Z., Dong, L., Yao, F., et al. (2023). Cartilage-Related Collagens in Osteoarthritis and Rheumatoid Arthritis: From Pathogenesis to Therapeutics. International journal of molecular sciences, 24(12), 9841.

2. Shin, J. W., Kwon, S. H., Choi, J. Y., et al. (2019). Molecular Mechanisms of Dermal Aging and Antiaging Approaches. International journal of molecular sciences, 20(9), 2126.

3. Kim, D. U., Chung, H. C., Choi, J., et al. (2018). Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, PlaceboControlled Study. Nutrients, 10(7), 826.

4. Barati, M., Jabbari, M., Navekar, R., et al. (2020). Collagen supplementation for skin health: A mechanistic systematic review. Journal of cosmetic dermatology, 19(11), 2820–2829.

5. Kviatkovsky, S. A., Hickner, R. C., Cabre, H. E., et al. (2023). Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults. Journal of the International Society of Sports Nutrition, 20(1), 2243252

6. Rondanelli, M., Faliva, M. A., Peroni, G., et al. (2021). Silicon: A neglected micronutrient essential for bone health. Experimental biology and medicine (Maywood, N.J.), 246(13), 1500–1511.

7. Mobasheri, A., Mahmoudian, A., Kalvaityte, U., et al. (2021). A White Paper on Collagen Hydrolyzates and Ultrahydrolyzates: Potential Supplements to Support Joint Health in Osteoarthritis. Current rheumatology reports, 23(11), 78.

Activates Telomerase to Lengthen Telomeres in Humans1

Improves Cardiovascular Markers in Patients with Metabolic Syndrome2

Helps Support Healthy Immune System3, 4

Enhances Immunity and Reduces Inflammation4

Review selected studies at www.telomerescience.com/studies

References

1. Salvador L, Singaravelu G, Harley CB, Flom P, Suram A, Raffaele JM. A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study. Rejuvenation Research. December 2016. 16(5).

2. Fernandez ML, Thomas MS, Lemos BS, DiMarco DM, Missimer A, Melough M, Chun OK, Murillo AG, Alyousef HM, Medina-Vera I. TA-65, A Telomerase Activator improves Cardiovascular Markers in Patients with Metabolic Syndrome. Current Pharmaceutical Design. 2018;24,1-7.

3. Singaravelu G, Harley CB, Raffaele JM, Sudhakaran P, Suram A. Double-Blind, Placebo-Controlled, Randomized Clinical Trial Demonstrates Telomerase Activator TA-65 Decreases Immunosenescent CD8+CD28-T Cells in Humans. OBM Geriatrics. 2021 vol. 5, issue 2.

4. Bawamia B, Spray L, Wangsaputra VK, Bennaceur K, Vahabi S, Stellos K, Kharatikoopaei E, Ogundimu E, Gale CP, Keavney B, Maier R, Hancock H, Richardson G, Austin D, Spyridopoulos I. Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction. Geroscience. 2023 Apr 22:1–17.

Telomere Athenaeum provides a new and exciting way to learn about telomere biology through education on the latest research from top experts in anti-aging medicine.

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Preserve Telomere Health Now: A

Clinical Imperative for Preventing AgeRelated Diseases and Extending Lifespan

By: Kathleen O’Neil Smith, MD, FAARM

Abstract

Telomeres, the protective caps at the ends of chromosomes, are critical for maintaining genomic stability. Their progressive shortening with each cell division is a key mechanism underlying cellular aging and age-related diseases. Emerging evidence suggests that interventions aimed at preserving telomere length, including lifestyle modifications and telomerase activation therapies, may offer significant benefits in delaying the onset of agerelated pathologies and extending healthspan. This article reviews the current understanding of telomere biology, the impact of lifestyle factors on telomere maintenance, and the potential role of telomerase activators, such as TA-65, in clinical practice.

Introduction

Telomeres function as essential guardians of chromosomal integrity, preventing genomic

instability that can lead to cell death or malignant transformation. Their structure, often likened to the plastic tips on shoelaces, prevents chromosomes from fraying and merging with neighboring chromosomes. However, telomeres naturally shorten with each round of cell division due to the “end-replication problem,” leading to eventual cellular senescence or apoptosis. This attrition is closely linked to aging and the increased incidence of age-related diseases, including cardiovascular diseases, cancer, and neurodegenerative disorders.

While most somatic cells exhibit minimal telomerase activity, which limits their ability to counteract telomere shortening, compounds like TA-65 have demonstrated potential in reactivating telomerase and may reverse certain aspects of cellular aging. This review explores the clinical relevance of telomere biology, with a focus on evidence-based strategies to maintain telomere length and promote healthy aging.

Telomere Biology

Telomere length is a key determinant of cellular function and longevity. Shortened telomeres are associated with an elevated risk of various age-related diseases. For instance, epidemiological studies have identified a correlation between shorter telomeres and higher incidences of myocardial infarction and stroke. 1 Understanding telomere biology is essential for clinicians involved in age management and preventive medicine.

Clinical Importance of Maintaining Healthy Telomere Length

Maintaining healthy telomere length is vital for sustaining cellular health and tissue regeneration. When telomeres reach a critically short length, cells either enter senescence, where they cease to divide and contribute to tissue dysfunction, or undergo apoptosis. This loss of cellular proliferative capacity is particularly detrimental in tissues that require constant renewal, such as the skin, immune system, and gastrointestinal tract. By preserving telomere length, clinicians can help ensure that these tissues continue to function effectively, thereby reducing the risk of chronic diseases and promoting longevity.

Lifestyle Factors Influencing Telomere Maintenance

Lifestyle factors significantly influence the rate of telomere attrition. Although genetic factors establish baseline telomere length, modifiable behaviors such as diet, physical activity, stress management, and sleep quality can either accelerate or decelerate telomere shortening.

Dietary Influence

A diet rich in antioxidants, vitamins, and omega-3 fatty acids is associated with longer telomeres. Omega-3 fatty acids, in particular, have been shown to protect against telomere shortening, suggesting a role in mitigating oxidative stress and inflammation, which are key drivers of telomere attrition.2 Conversely, diets high in processed foods, refined sugars, and unhealthy fats may exacerbate telomere shortening, potentially accelerating the aging process.

Physical Activity

Regular aerobic exercise has been shown to preserve telomere length, possibly through its effects on reducing oxidative stress and systemic inflammation. Clinical studies indicate that individuals who maintain an active lifestyle exhibit longer telomeres compared to sedentary counterparts, highlighting the importance of physical activity in delaying the onset of age-related diseases.3

Stress Management

Chronic stress is a well-established accelerator of telomere shortening, likely mediated through fluctuating cortisol levels and increased oxidative stress.4 Interventions such as mindfulness practices, including meditation and yoga, have been shown to lower stress and may contribute to the maintenance of telomere length by optimizing cortisol production and enhancing telomerase activity.

Sleep Quality

The relationship between sleep and telomere length underscores the importance of sleep in aging and disease prevention. Poor sleep quality or chronic sleep deprivation has been linked to shorter telomeres, likely due to increased oxidative stress and inflammation.5 Clinicians should emphasize the importance of adequate and restful sleep as a simple yet powerful intervention for protecting telomere health.

Telomerase Activation and the Clinical Potential of TA-65

Telomerase activation represents a promising approach to preserving telomere length and promoting healthy aging. TA-65, a small molecule telomerase activator, has garnered attention for its ability to enhance telomerase activity, thereby potentially rejuvenating aging cells. Clinical studies have demonstrated that TA-65 can improve immune function, notably by increasing natural killer (NK) cell activity and reducing inflammatory markers, which may lower the risk of infections and malignancies in older adults.6

Preclinical studies in murine models further suggest that TA-65 supplementation may extend healthspan,

characterized by improved metabolic function, increased physical activity, and delayed onset of age-related diseases.7 Although definitive evidence in humans is still forthcoming, these findings highlight the potential of telomerase activation as a cornerstone of anti-aging therapy.

Clinical Application of Telomere Science

The integration of telomere biology into clinical practice offers healthcare providers valuable tools for the prevention and management of age-related diseases. Telomere length assessments, combined with targeted lifestyle interventions and potential telomerase activation therapies, can form a comprehensive strategy for promoting longevity and improving patient outcomes. Clinicians should educate patients on the importance of telomere health and the lifestyle factors that influence telomere dynamics. By guiding patients on diet, physical activity, stress management, and sleep hygiene, healthcare providers can empower them to take proactive steps

toward healthy aging. Additionally, incorporating telomerase activators like TA-65 into clinical protocols, alongside monitoring of telomere length, can enhance the effectiveness of anti-aging interventions and provide a personalized approach to age management.

Conclusion

Telomere biology offers profound insights into the mechanisms of aging and the potential for interventions that preserve cellular health. By focusing on strategies that maintain telomere length, such as lifestyle modifications and telomerase activation, healthcare providers can help slow the aging process, improve longevity, and enhance quality of life. As research in this field advances, the future of anti-aging medicine holds promise for unlocking new pathways to healthier aging.

Author Bio:

Dr. Kathleen O’Neil Smith, MD, FAARM, is a magna cum laude graduate of Boston University School of Medicine with postgraduate training from Harvard’s Massachusetts General Hospital and Brigham and Women’s Hospital. An elite athlete and national rowing team member for over 40 years, Dr. O’Neil

References:

1. Yeh JK, Wang CY. Telomeres and telomerase in cardiovascular diseases. Genes (Basel). 2016;7(9):58. doi:10.3390/genes7090058. PMCID: PMC5042389. PMID: 27598203.

2. Ogłuszka M, Lipiński P, Starzyński RR. Effect of omega-3 fatty acids on telomeres—Are they the elixir of youth? Nutrients. 2022;14(18):3723. doi:10.3390/nu14183723. PMCID: PMC9504755. PMID: 36145097.

3. Arsenis NC, You T, Ogawa EF, Tinsley GM, Zuo L. Physical activity and telomere length: impact of aging and potential mechanisms of action. Oncotarget. 2017;8(27):45008-45019. doi:10.18632/oncotarget.16726. PMCID: PMC5546536. PMID: 28410238.

4. Yegorov YE, Poznyak AV, Nikiforov NG, Sobenin IA, Orekhov AN. The link between chronic stress and accelerated aging. Biomedicines. 2020;8(7):198. doi:10.3390/biomedicines8070198. PMCID: PMC7400286. PMID: 32645916.

5. Sabot D, Lovegrove R, Stapleton P. The association between sleep quality and

Smith transitioned to Regenerative Medicine in 2008, founding “Treat Wellness” in Boston, where she specializes in Functional, Integrative, and Regenerative Medicine. An international thought leader in peptide therapy and exosomes, she is also a co-author of Kick Covid-19 to the Curb and Fine-Tune Your Immune System.

telomere length: a systematic literature review. Brain Behav Immun Health. 2023;28:100577. doi:10.1016/j.bbih.2022.100577. PMCID: PMC9860369. PMID: 36691437.

6. Bawamia B, Spray L, Wangsaputra VK, et al. Activation of telomerase by TA-65 enhances immunity and reduces inflammation post-myocardial infarction. GeroScience. 2023;45(4):2689-2705. doi:10.1007/s11357-023-00794-6. PMCID: PMC10122201. PMID: 37086366.

7. de Jesus BB, Schneeberger K, Vera E, Tejera A, Harley CB, Blasco MA. The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell. 2011;10(4):604-621. doi:10.1111/j.1474-9726.2011.00700.x. PMCID: PMC3627294. PMID: 21426483.

Galectin-3 and Its Association with Dementias: The Potential of TB006 to Reverse Dementias

By: Arbella Sarkis, MD1, and John Bumb2

Abstract

In humans, Galectin-3 (GAL-3) is a protein that is encoded by the LGALS3 gene. Specifically, it is a β-galactosides and glycan-binding glycoprotein is frequently upregulated by reactive microglia/ macrophages in the CNS during various neurological diseases. While GAL-3 has previously been associated with non-CNS inflammatory and fibrotic diseases, recent studies highlight GAL-3 as a prominent regulator of inflammation and neuroaxonal damage in the CNS during diseases such as multiple sclerosis, Alzheimer’s Disease (AD), and Parkinson’s Disease (PD)1. Through clinical observation, the authors describe the clinically observed benefits of rendering excess GAL-3 bio unavailable.

Introduction

This article aims to illustrate that by rendering GAL-3 bio-unavailable, there is now a potential to reverse all types of dementia utilizing the investigational drug TB006. Doing so absent contraindications to all but a few medications, minimal side effects, and no drugrelated Significant Adverse Events reported to date.

Dementia is a broad term for brain diseases that lead to a gradual or rapid decline in cognitive abilities, affecting memory, coordination, and communication skills. This decline can significantly impact a person’s daily functioning and, ultimately, their mortality. AD is the most common form of dementia, characterized by the deposition of extracellular aggregates of amyloid-β (Aβ) and the formation of intraneuronal tau neurofibrillary tangles. It is important to note

Galectin-3 and Its Association with Dementias: The Potential of TB006 to Reverse Dementias

that recent studies argue that the extracellular amyloid and tau aggregates play a minor role in cognitive decline. Recent research has highlighted the role of GAL-3, a member of the galectin family, in the pathogenesis of AD and other dementias. This article aims to provide an overview of GAL-3, its biological functions, its association with dementia, and case examples by the authors.

1Family Practice, Integrative and Regenerative Medicine, Medical Director, Gentle Touch Medical Group. Los Gatos, CA, USA

2 Independent researcher, CEO, Metaverse One. Los Gatos, CA, USA

A Brief History of GAL-3

• 1982: GAL-3 identified in murine peritoneal macrophages.

• 1991: GAL-3 classified as a galactoside-binding lectin.

• For Diseases:

• Heart Failure: Significant research began emerging in the early 2000s.

• Chronic Kidney Disease (CKD): Associations with GAL-3 were studied in the late 2000s.

• Atherothrombosis: Research on GAL3’s role intensified in the 2010s.

• Neuroinflammation: Studies on GAL-3 in neurodegenerative diseases gained traction in the 2010s.

Biological Functions of GAL-3

GAL-3 is multifunctional and involved in various cellular processes, including cell adhesion, proliferation, cell differentiation, apoptosis, fibrosis, inflammation, tumor progression and metastasis, angiogenesis, microglia activation, antimicrobial activity, cell cycle regulation, chemoattraction, wound healing, glycoprotein and glycolipid interactions, and immune cell activation and responses. GAL-3 is characterized by a conserved sequence within the carbohydrate recognition

domain (CRD). CRD is responsible for its lectinbinding activity. The CRD binds to β-galactosides, facilitating interactions with glycoproteins on the cell surface and in the extracellular matrix.

GAL-3 is versatile and expressed in a wide range of tissues. This includes the immune system, where plays a crucial role in modulating inflammation and immune responses. It plays roles in innate and adaptive immunity, influencing phagocytosis, cytokine production, and T-cell activation. In the central nervous system (CNS), GAL-3 is primarily expressed in microglia, the brain’s resident immune cells.

GAL-3 acts as a first responder fireman to cellular damage and insults in the right amounts. In excess amounts, it can be as impactful as a terrorist employing a weapon of mass destruction.

GAL-3 and Microglial Activation

As the primary immune cells in the CNS play a central role in neuroinflammation, a key feature of many neurodegenerative diseases, including AD. GAL-3 has been identified as a key player in microgliamediated neuroinflammation. It is highly upregulated in the brains of AD patients and animal models of AD, specifically in microglia associated with Aβ plaques2 .

GAL-3 modulates microglial activation through various mechanisms. It acts as a ligand for the triggering receptor expressed on myeloid cells 2 (TREM2), a key receptor driving microglial activation in AD. The interaction between GAL-3 and TREM2 enhances microglial phagocytosis of Aβ, promoting the clearance of amyloid plaques. Additionally, GAL-3 influences the production of pro-inflammatory cytokines, contributing to the neuroinflammatory response in AD2

GAL-3 and Macrophage Activation

Specifically, GAL-3 can drive macrophages towards an M2-like phenotype, which is associated with tissue repair and fibrosis3. However, in the context of chronic inflammation, this can lead to excessive scar tissue formation and numerous

other impairments of normal brain function3

Regeneration of Microglia and Macrophages

As age increases, the regeneration rate of both the microglia and macrophages slows down due to factors like immunosenescence (age-related decline in cellular immune function) and chronic inflammation (often referred to as “inflammaging”). Inflammation caused by excesses of GAL-3 can significantly exacerbate and accelerate these processes.

GAL-3 as a Biomarker for Alzheimer’s Disease

Several studies have explored the potential of GAL-3 as a biomarker for AD. Elevated levels of GAL-3 have been detected in the serum of AD patients compared to healthy controls. The degree of cognitive impairment, as measured by the Mini-Mental State Examination (MMSE) score, has been found to correlate with GAL-3 serum levels4. These findings suggest that GAL-3 could be a valuable biomarker for diagnosing and progressing AD.

In addition to its role as a biomarker, GAL-3 has been implicated in the pathogenesis of AD. Studies have shown that GAL-3 expression is upregulated in response to Aβ deposition and tau aggregation, two hallmark features of AD. The increased expression of GAL-3 in microglia associated with Aβ plaques suggests that it plays a role in the neuroinflammatory response to amyloid pathology5

GAL-3 and Other Dementias

While most research on GAL-3 has focused on its role in AD, there is evidence to suggest that GAL-3 is involved in most other forms of dementia. For example, GAL-3 has been implicated in the pathogenesis of vascular dementia (VaD), a type of dementia caused by reduced blood flow to the brain. In animal models of VaD, GAL-3 expression is upregulated in response to ischemic injury, and its inhibition has been shown to reduce neuroinflammation and improve cognitive function.

GAL-3 has been associated with other neurodegenerative

diseases, such as PD and Amyotrophic Lateral Sclerosis (ALS). In these diseases, GAL-3 is believed to contribute to neuroinflammation and neuronal damage, like its role in AD. These findings suggest that GAL-3 may be a significant common mediator of neuroinflammation in various neurodegenerative diseases. Of note and in support of this hypothesis, the authors have observed patients in their clinical setting having dementia and accompanied indication of PD respond markedly well to TB006 therapy.

Therapeutic Potential of Targeting GAL-3

Given its involvement in neuroinflammation and neurodegeneration, GAL-3 represents a potential therapeutic target for dementia. Several strategies have been proposed to target GAL-3, including using small-molecule inhibitors, monoclonal antibodies, and gene therapy approaches.

Small molecule inhibitors of GAL-3 have shown some promise in preclinical studies. These inhibitors block the carbohydrate-binding site of GAL-3, preventing its interaction with glycoproteins. The authors are not aware of a successful small molecule inhibitor being successful in human clinical studies.

Monoclonal antibodies targeting GAL-3 have also been developed and are under development. One of these antibodies, specifically TB006 binds to GAL-3 at specific sites, neutralizing its bioactivity and promoting proper functioning of the immune system and its clearance from the brain. In preclinical and clinical studies, this anti-GAL-3 antibody has been shown to reduce microglial activation, Aβ deposition, neurodegeneration, neuroinflammation and has demonstrated the potential to reverse most forms of dementia.

Case Studies

Under the FDA-approved TB006 Expanded Access Program (EAP), sponsored by the manufacturer TrueBinding, Inc., Foster City CA, the authors have the benefit of administering TB006 under the protocols of the EAP and observing in the clinical setting many subjects and hereby provide select, but not uncommon outcomes reflected in following case histories of three subjects:

CASE 1 - 91-year-old white female, former CPA

• Memory loss – MMSE 15/30, Not much improvement on Exelon Patch 13.5mg daily - Namenda 10mg twice/day for nearly 10 years - Isolated with minimal communication - No involvement in regular daily tasks.

• History of: Breast cancer - Autoimmune disease - Hypothyroidism

• Post First Dose: MMSE score improved to 19 from 15 - Participating more in daily tasksMore engaged in conversation with her husband/ friends - Solves daily math problems.

• Post Second Dose: MMSE score improved to 23 from 19 - Patient was socializing more - Physically more active - Engaged in cooking, household, and other activities

• Post Third Dose: MMSE score improved to 25 from 23 - Restarted wearing makeup again – Selfdressing and proper coordination of clothing - Calculating checks and tips at restaurants

CASE 2 - 94-year-old African American female, a retired teacher with a medical history of: - Untreated dementia by former PCP with severe decline of daily living activities - MMSE score of 13/30 1st visit

• History of: CAD – CHF – Hypertension - Gout

• Following TB006 Treatment - First Two Weeks: More engaged and attentive - Humor returning - More consistently and easily recalling names and eventsdaughter of patient stated her mother arrived home right after her first treatment and went straight to the family room picked up the TV remote control and changed the channel to watch her program, she had not been able to operate the remote for >6 months.

• Second Two Weeks: Able to follow a challenging conversation - Could remember both sets of “three words” of MMSE - Physically more active.

• At 2nd Treatment, Post First Dose: MMSE score improved to 21 from 13 - Active participant in-home discussions - She was less short of breath and could walk longer distances.

• Post Second Dose: 7 weeks into treatment,

MMSE score improved to 22 from 21 – However, the patient was more involved in family activities and had an improved sense of humor and alertness.

CASE 3 - 90-year-old white female with a medical history of: Senile Dementia – MMSE score 18/30

• History of: Malignant hypertension with frequent average systolic BP 170 mmHg frequently spiking up to 210-240 mmHg on multiple blood pressure medications – CAD - Pulmonary embolism - on Eliquis - Sleeps all day - Nausea – Frequent vomiting of unknown cause - Significant intolerance to cold - Chronic generalized body aches - back pain

- knee pain - History of multiple falls - Urinary incontinence - Home bound for 2 years.

• Following TB006 Treatment - First Two Weeks: Marked improvement in memory - Able to remember her birthday and day of week - Marked reduction in pain - BP dramatically improved (averaging 120-130) - Mood improvement – calmer - less anxious - more alert/awake - more energized.

• Second Two Weeks: Intolerance to cold resolvedNausea and vomiting resolved - requested caregiver to pull bright red suit from the closet to visit her son and visit him - Increased participation with friends and family - No longer laying on the couch most of the day.

• Immediately Prior to Second Dose: MMSE score improved to 22 from 18: Memory continued to improve - Incontinence largely resolved - Continues to be more alert and interactive - normal tolerance to cold.

• Four Weeks Post Second Dose: MMSE score improved to 25 from 22: Improved alertness

- Participation with family activities - Blood pressure continues to maintain at normal levels.

Conclusion

GAL-3 is a multifaceted protein that plays a crucial role in the pathogenesis of AD and other dementias. Its involvement in microglia-mediated neuroinflammation and its potential as a biomarker and therapeutic target make it an important focus of ongoing research. Improvement in other secondary indications of subjects treated with TB006 implies the

multiple roles GAL-3 plays in many other diseases. In conclusion, the author believes that TB006’s high selectivity renders excess GAL-3 bio-unavailable and that it is unlikely other factors played a role during or after the treatment of subjects. This is demonstrated by the marked changes observed in several subjects, suggesting that TB006 has the potential to be a transformational therapy not only for Alzheimer’s disease and other dementias, but also for all diseases in which GAL-3 is involved.

Declaration of Conflicting Interests

The author, Arbella Sarkis, MD, is a Principal Investigator and clinical instructor of Principal Investigators of the TB006 Expanded Access Program sponsored by TrueBinding, and the author, John Bumb, is an assistant to the First Author, independent researcher, and CEO of Metaverse One. LLC. Neither author has been compensated or has other potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References:

1. Lozinski, Brian M.; Ta, Khanh; Dong, Yifei, Emerging role of galectin-3 in neuroinflammation and neurodegeneration. Neural Regeneration Research 19(9):p 2004-2009, September 2024. | DOI: 10.4103/1673-5374.391181nces

2. Mélanie Lalancette-Hébert, Vivek Swarup, Jean Martin Beaulieu, Ivan Bohacek, Essam Abdelhamid, Yuan Cheng Weng, Sachiko Sato and Jasna Kriz, Galectin-3 Is Required for Resident Microglia Activation and Proliferation in Response to Ischemic Injury, Journal of Neuroscience 25 July 2012, 32 (30) 10383-10395; https://doi.org/10.1523/ JNEUROSCI.1498-12.2012***

3. Hsin-Ying Lu,Chun-Ming Shih,Chun-Yang Huang,Alexander T. H. Wu,Tsai-Mu Cheng,Fwu-Long Mi and Chun-Che Shih, Galectin-3 Modulates Macrophage Activation and Contributes Smooth Muscle Cells Apoptosis in Abdominal Aortic Aneurysm Pathogenesis, Int. J. Mol. Sci. 2020, 21(21), 8257; https://doi. org/10.3390/ijms21218257

4. Tan, Y., Zheng, Y., Xu, D. et al. Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer’s disease. Cell Biosci 11, 78 (2021). https:// doi.org/10.1186/s13578-021-00592-7

5. Xuexin Wang, MM1,2, Shuping Zhang, BM3 , Faliang Lin, MM2 , Wenzheng Chu, MD4 , and Shouwei Yue, MD, Elevated Galectin-3 Levels in the Serum of Patients With Alzheimer’s Disease sagepub.com/journalsPermissions.nav DOI: 10.1177/153

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How Oxidative Stress Influences Biological Aging

By: Adair Anderson, MS, RDN, LDN & Tyana Smith, MA

Oxidative stress is a significant determinant of cellular function and longevity, representing the imbalance between free radicals and antioxidants in the body.

This imbalance leads to cellular damage and is a key factor in the aging process beyond chronological age. Through inflammatory processes and early development of age-related diseases, oxidative stress can cause biological aging—a deterioration of the body’s cells and tissues that doesn’t necessarily correlate to the number of years lived.1

This editorial explores the role of oxidative stress in biological aging and discusses strategies to mitigate its effects.

The Science of Oxidative Stress and Aging

Understanding oxidative stress and its impact on aging can reveal the underlying causes of

cellular wear, offering insights into strategies for slowing the aging process. Specifically, examining the balance between damaging free radicals and protective antioxidants helps clarify the causes of cellular deterioration and supports strategies to enhance health span and longevity.

Oxidative stress occurs when there’s an imbalance between reactive oxygen species (ROS), reactive nitrogen species (RNS), and antioxidants within the body. These reactive species are collectively known as free radicals, unstable molecules with an uneven number of electrons, allowing them to react with other molecules easily.

While these reactions are normal cellular processes, they can cause significant damage when free radicals outnumber antioxidants. These molecules can donate an electron to a free radical without becoming unstable themselves, thus neutralizing the free radical and preventing potential damage.

How Oxidative Stress Influences Biological Aging

Maintaining a balance between free radicals and antioxidants is vital for preserving cellular function and overall health. However, when free radicals are in excess or antioxidants are deficient, oxidative stress occurs, damaging proteins, lipids, and DNA—ultimately contributing to cellular aging and dysfunction.7

Biological Age and Oxidative Stress

Research has consistently linked oxidative stress to accelerated biological aging.2 Biological age, as opposed to chronological age, reflects the physiological state of an individual’s cells, tissues, and organs, essentially indicating how “old” these systems are in terms of function and resilience.

Oxidative damage accumulates over time, exacerbated by lifestyle factors, environmental exposures, and genetic predispositions, leading to increased cellular senescence and a decline in regenerative capacities6. This accumulation not only influences the onset and progression of age-related diseases such as cardiovascular disease, diabetes, and neurodegenerative disorders but also affects the overall healthspan, the period of life spent in good health.

Studies demonstrate a direct link between mitochondrial oxidative stress—the primary source of oxidative stress—and a deteriorated healthspan.1 Thus, managing oxidative stress is essential in slowing biological aging and improving the quality of life in later years.

The Impact of Oxidative Stress on Health

Oxidative stress is closely linked to health, driving cellular damage and aging and triggering agerelated diseases. Understanding its role highlights the importance of managing oxidative balance to prevent disease and promote well-being.

Oxidative stress profoundly impacts cellular and molecular structures, including DNA, proteins, and lipids. This damage plays a central role in the aging process and the functional decline of cells over time. When free radicals outnumber antioxidants, they can attack important biomolecules, leading to oxidative damage.

DNA, the blueprint of cellular function, is particularly vulnerable to oxidative damage.7 ROS can damage DNA by causing mutations and base modifications that disrupt genetic information and integrity.5 By attacking the DNA base guanine, oxidative stress damages telomeres directly and accelerates telomere shortening, accelerating the aging process.6

Additionally, oxidant species can also harm proteins and lipids. Proteins, which perform critical functions such as catalyzing biochemical reactions and signaling, can become denatured or form harmful aggregates when oxidized.7 Lipids, particularly those comprising cell membranes, can undergo peroxidation, leading to the deformation of cell structures—this process is associated with anomalies in cell metabolite transport that can affect physiological function.6 This cascade of damage disrupts cellular homeostasis and can accelerate aging, contributing to the decline in tissue and organ function.9

Age-Related Diseases Linked to Oxidative Stress

As we age, we become more vulnerable to diseases like heart disease, diabetes, neurological disorders, and cancers. However, with accelerated biological aging, these conditions may manifest earlier in life.8 The cellular and molecular damage caused by oxidative stress accelerates the aging process, driving the onset of age-related diseases such as cardiovascular disorders, neurodegenerative diseases, diabetes, and inflammatory conditions.2

Oxidative stress contributes to the development of cardiovascular diseases by promoting atherosclerosis, hypertension, and myocardial infarction. Oxidative damage to lipids, specifically low-density lipoprotein (LDL) cholesterol, plays a significant role in the initiation and progression of atherosclerosis.6

In diabetes, oxidative stress is both a cause and a consequence of insulin resistance and beta-cell dysfunction.3 High levels of free radicals can disrupt glucose metabolism, leading to hyperglycemia and further oxidative stress, exacerbating the condition.8

Neural diseases such as Alzheimer’s, Parkinson’s, and Huntington’s are also associated with oxidative stress.9

The brain is particularly vulnerable to oxidative damage due to its high oxygen consumption and abundance of easily oxidizable fatty acids. Oxidative stress can lead to neuronal death and the accumulation of misfolded protein aggregates, which are characteristic of these diseases.4

Finally, oxidative stress can contribute to the initiation and progression of cancer by causing DNA damage, promoting mutations, and altering cellular signaling pathways. It can also affect tumor microenvironments, influencing cancer cell growth, metastasis, and resistance to therapy.5

Assessing Oxidative Stress Markers

Understanding and measuring oxidative stress is pivotal to evaluating its impact on health and disease progression. Various methods exist for assessing oxidative stress markers, offering insights into the balance between free radicals and antioxidants in the body.

Direct Measurement of Free Radicals

Directly measuring free radicals presents significant challenges due to their highly reactive and transient nature.9 Advanced techniques like Electron Spin Resonance (ESR) spectroscopy can detect specific types of free radicals, providing a direct but technically demanding approach to assessing oxidative stress.8

Indirect Measurement of Damage Markers & Antioxidants

Given these challenges, research has shifted toward indirect methods, focusing on oxidative damage markers (e.g., lipid peroxidation products, protein carbonyls, glycation end products) and antioxidant levels. These indirect markers provide a more reliable assessment of oxidative stress by measuring the aftermath of ROS/ RNS activity or the body’s defensive capacity against oxidative damage, thus circumventing the challenges associated with directly measuring reactive species.3

Indirect diagnostic tools can measure markers of cumulative oxidative damage eliminated from the body in the urine and genetic variants that code for enzymes and antioxidants that can significantly impact the oxidative stress response.

These tests provide insights into oxidative damage to DNA, RNA, lipids, and proteins, along with genetic predispositions. Such insights allow for personalized treatment plans that support the body’s natural antioxidants (through dietary sources) for optimal antioxidant creation and recycling.

Strategies to Manage Oxidative Stress

After evaluating the level of oxidative stress, the next step is to implement strategies to reduce and manage this damaging form of inflammation. Key management strategies include:

• Reduce Toxic Burden: Environmental exposure to toxins, heavy metals, pollutants, and industrial chemicals can trigger oxidative stress by catalyzing ROS production, promoting free radical production, depleting antioxidants, and inhibiting their protective functions.5 Testing for toxic burden can identify and help reduce toxins contributing to oxidative stress.

• Focus on an Antioxidant-Rich Diet: Foods like berries, leafy greens, nuts, seeds, and vegetables contain a wealth of antioxidants that directly neutralize harmful free radicals in the body, reducing oxidative stress.4 This approach supports the body’s natural defense mechanisms, promoting cellular health and helping to prevent oxidative damage that contributes to aging and chronic diseases.

• Utilize Precision Supplements and Antioxidants: Personalized supplements can provide essential antioxidants and strengthen the body’s own antioxidant production. These can include nonenzymatic antioxidants such as coenzyme Q10, melatonin, vitamins A, C, E, and selenium.8

• Embrace Polyphenols: Polyphenols, a diverse group of naturally occurring compounds found in plants, have been shown to decrease oxidative damage markers and increase antioxidant levels. Rich sources include fruits, vegetables, tea, coffee, wine, and chocolate.4

• Adopt Healthy Lifestyle Habits: Smoking cessation, limiting alcohol intake, and increasing quality sleep directly combat the accumulation of harmful free radicals, promoting cellular repair and balance.9

How Oxidative Stress Influences Biological Aging

These adjustments are foundational to maintaining a healthy antioxidant-to-free-radical ratio, crucial for minimizing oxidative damage and supporting longevity.

• Understand the Dual Role of Oxidative Stress: While excessive oxidative stress is detrimental, moderate levels induced by optimal exercise can be beneficial. Exercise activates hormesis, where exposure to mild stress triggers adaptive responses in cells and organisms, enhancing their resistance to higher stress levels and improving overall health and function.9 This process strengthens the body’s stress response mechanisms, improving durability and longevity.

The Biological Aging & Health Span Connection

Oxidative stress is inextricably linked to biological aging, serving as both a marker and a mechanism that drives the gap between our biological and

About the Authors:

Adair Anderson, MS, RDN, LDN

Adair Anderson is an Idaho-based Registered and Licensed Dietitian and Product Marketing Manager for Vibrant Wellness. She specializes in gut health and digestive conditions and has a master’s degree in clinical nutrition. Be it solving digestive mysteries or finishing her first skate ski race, Adair is energized by the steady and deliberate journey from novice to competence. She is thrilled by learning new facts—and sharing them with others.

Contact: Adair.A@vibrant-wellness.com, (866)-364-0963

chronological ages. This dynamic underscores the complex interplay between environmental factors, lifestyle choices, and genetic predispositions that collectively influence our health and longevity.

As we better understand the impact of oxidative stress on cellular integrity, its role in the onset and progression of age-related diseases becomes increasingly evident. Measuring oxidative stress can aid clinicians in designing personalized strategies for managing it, potentially mitigating its effects on biological aging and promising a healthier, more vibrant future for individuals at all stages of life.

Tyana Smith, MA

Tyana Smith combines her passion for health optimization with her love of words and marketing as the Senior Content and Brand Marketing Manager at Vibrant Wellness. She hopes her writing will arm wellness professionals with the knowledge and insights they need to transform patient outcomes and make personalized, root-cause healthcare more accessible to all. Tyana is infinitely curious and stays at the forefront of biohacking trends and scientific research to better serve her audience—and, selfishly, herself. She’s a proud graduate of Johns Hopkins University’s Zanvyl Krieger School of Arts and Sciences, where she received a master’s degree in communication, focused on unpacking complex topics to make them accessible and engaging.

Contact: Tyana@wellproz.com, (866)-364-0963

References:

1. Bondy, S. C., & Campbell, A. (Eds.). (2016). Inflammation, aging, and oxidative stress. Springer. https://doi.org/10.1007/978-3-319-33486-8

2. Dai, D. F., Chiao, Y. A., Marcinek, D. J., Szeto, H. H., & Rabinovitch, P. S. (2014). Mitochondrial oxidative stress in aging and healthspan. Longevity & Healthspan, 3(6). https://doi.org/10.1186/2046-2395-3-6

3. Dubois-Deruy, E., Peugnet, V., Turkieh, A., & Pinet, F. (2020). Oxidative stress in cardiovascular diseases. Antioxidants, 9(9), Article 864. https://doi.org/10.3390/ antiox9090864

4. Fenercioglu, A. K., Saler, T., Genc, E., Sabuncu, H., & Altuntas, Y. (2010). The effects of polyphenol-containing antioxidants on oxidative stress and lipid peroxidation in Type 2 diabetes mellitus without complications. Journal of Endocrinological Investigation, 33(2), 118–124. https://doi.org/10.1007/ BF03346565

5. Hayes, J. D., Dinkova-Kostova, A. T., & Tew, K. D. (2020). Oxidative stress in cancer. Cancer Cell, 38(2), 167–197. https://doi.org/10.1016/j.ccell.2020.06.001

6. Khatana, C., Saini, N. K., Chakrabarti, S., Saini, V., Sharma, A., Saini, R. V., & Saini, A. K. (2020). Mechanistic insights into the oxidized low-density lipoprotein-induced atherosclerosis. Oxidative Medicine and Cellular Longevity, 2020, Article 5245308. https://doi.org/10.1155/2020/5245308

7. Menezo, Y. J. R., Silvestris, E., Dale, B., & Elder, K. (2016). Oxidative stress and alterations in DNA methylation: Two sides of the same coin in reproduction. Reproductive BioMedicine Online, 33(6), 668–683. https://doi.org/10.1016/j. rbmo.2016.09.006

8. Oguntibeju, O. O. (2019). Type 2 diabetes mellitus, oxidative stress and inflammation: Examining the links. *International Journal of Physiology, Pathophysiology and Pharmacology, 11*(3), 45–63. PMID: 31333808; PMCID: PMC6628012.

9. Radak, Z., Chung, H. Y., Koltai, E., Taylor, A. W., & Goto, S. (2008). Exercise, oxidative stress and hormesis. Ageing Research Reviews, 7(1), 34–42. https://doi. org/10.1016/j.arr.2007.04.004

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CellCore provides supplements designed to address underlying factors that impact aging, such as toxins and harmful pathogens.* By enhancing mitochondrial function, promoting e cient drainage, and supporting detoxiﬁcation, we help optimize your body’s energy production and overall organ health for long-term vitality.* Our proprietary BioActive Carbon® blend ensures e ective nutrient delivery and cellular protection to slow the aging process and promote longevity.*

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Numerous testimonials from practitioners and patients alike show excellent results addressing gut-brain conditions as well as pain, diabetic neuropathy and more using our powerful and safe LED light therapy. In a pilot study, the average Mini-Cog score improved by 7% from the pre-trial to the post-trial exams. The scores improved another 26% from the post trial exam to the post washout period exam. The overall average Mini-Cog score improved by 35%.

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Our full package includes a dual channel digital frequency function generator, an Fscan, and a laptop loaded with our software app.

“Our Acupuncture practice in Natick Massachusetts chose to add Firefly Light Therapy for conditions associated with pathogens, pain, and neurological conditions. We have seen remarkable results. The Firefly Light device is truly a valuable asset to any clinic that appreciates the latest cutting-edge therapy.”

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4 Reasons to Bring Vagus Nerve Stimulation into Your Practice

1. Proven to Stimulate the Vagus Nerve: gammaCore™ non-invasive vagus nerve stimulator (nVNS) and Truvaga™ products directly stimulate the vagus nerve at the neck, where it can access the majority of vagal fibers.1,2

2. Clinically Proven: gammaCore has 6 FDA clearances for headache pain, while Truvaga supports stress relief and nervous system balance.

3. Improved Patient Outcomes: Vagus nerve stimulation (VNS) offers an additional option for patients unresponsive to traditional therapies, improving outcomes and quality of life.

4. Rising Demand: Offering VNS meets the growing demand for non-invasive, drug-free solutions, positioning your practice as a leader in innovative care.

Stop by booth #7119 to learn how non-invasive vagus nerve stimulation can enhance your practice.

Indications and Important Safety Information

Scan the QR code to learn more.

gammaCore™ is intended to provide non-invasive vagus nerve stimulation (nVNS) on the side of the neck for preventive treatment of migraine and the acute treatment of pain associated with migraine in patients 12 and older. gammaCore is also indicated for adjunctive use for preventive treatment of cluster headache, acute treatment of episodic cluster headache, and treatment of hemicrania continua and paroxysmal hemicrania in adult patients. gammaCore should not be used by people with an active implantable medical device or have a metallic device implanted at or near the neck.

NOTE: This list is not all inclusive. Please refer to gammaCore.com or Instructions for Use for complete safety information, including indications, contraindications, warnings, precautions, and instructions, before using or prescribing this product.

Available by prescription only. US Federal Law restricts this device to sale by or on the order of a licensed healthcare provider. Truvaga™ products are general wellness products and as such have not been evaluated by the US Food and Drug Administration. They are not intended to diagnose, treat, cure, or prevent any disease or condition.

References: 1. Nonis, R., D’Ostilio, K., Schoenen, J., & Magis, D. (2017). Evidence of activation of vagal afferents by non-invasive vagus nerve stimulation: An electrophysiological study in healthy volunteers. Cephalalgia, 37(13), 1285–1293. https://doi.org/10.1177/0333102417717470

2. Frangos, E., & Komisaruk, B. R. (2017). Access to vagal projections via cutaneous electrical stimulation of the neck: FMRI evidence in healthy humans. Brain Stimulation, 10(1), 19–27. https://doi.org/10.1016/j.brs.2016.10.008

EXHIBITOR INDEX

10X Health System 2079

3x4 Genetics 8027

4Ever Young Anti-Aging Solutions ............... 1096

A Fashion Hayvin .............................. Foyer

A4M ......................................... 5000

AC Grace Company ............................ 2033

Accelerated Medical Practices 9036

Access Medical Labs 5011

Acella Pharmaceuticals 3099

Adaptia Design ............................... 9118

Advanced Longevity ........................... 8116

Ageless Ambition Media ....................... 7125

Alight Health Formulas ......................... 8095

Aligned Modern Health 2076

Allergy Research Group 5079

Alletess Medical Laboratory .................... 9013

Alliance for Pharmacy Compounding ............. 9124

American Cell Technology ...................... 7066

American Herbal Labs & Nano Herbs Light ....... 4038

American Wellness Pharmacy 7103

AnazaoHealth 3055

Ancient Nutrition 7123

Apex Energetics ............................... 4045

Arete Regenerative Technologies ................ 3062

Argentyn 23 & Sovereign Copper ................ 7061

ASEA ........................................ 2125

Atrantil - KBS Research 8129

Aura Wellness 8118

Auro Wellness 1027

AVACEN, Inc ................................. 9043

AYUMETRIX .................................. 6046

Ayush Herbs Inc. .

3079

Bales Photonics, Inc. ........................... 2032

Calroy Health Sciences ......................... 4026

Canada RNA Biochemical Inc ................... 4048

Cancer Check Labs ............................ 3102

Candela Medical 3060

Canfield Scientific 6048

CardieX 7073

Cardio Vision Care MP ......................... 2091

CAROL Bike .................................. 9091

CasaPharmaRX ............................... 3124

Cell Science Systems........................... 1102

Cell Surgical Network 1040

Cellcore Biosciences 2035

Cellebration LLC 1100

Central Drugs Compounding Pharmacy .......... 1027

Centropix .................................... 8034

Cerbo ........................................ 4103

Chilly GOAT Cold Tubs by Master Spas ........... 8117

Chi’s Enterprises Inc. 5042

ChromaDex, Inc. 4044

Clinicians Supplement Consultants 7046

College Pharmacy ............................. 6038

Compounder’s International Analytical Laboratory (CIAL) . 1094

Congela Biocosmetics.......................... 5075

Cool Blue VA 8104

COSMED USA 9046

CRE8 Pharmacy 3033

CRMLab ..................................... 7113

Cryobuilt ..................................... 6079

Cyrex Laboratories ............................ 3032

DAAS GENIUS ................................ 2128

Daiwa By US Jaclean, Inc. 8043

Darmerica 1048

DaVinci Laboratories 6117

Delavie Sciences .............................. 9105

Designer Drugs Pharmacy ...................... 7043

Designs for Health ............................ 2021

DEXA+ ...................................... 8101

Diagnoptics Technologies b.v 9035

Diagnostic Solutions Lab 1021

Doctor Multimedia 3042

Doctor’s Data, Inc. ............................. 7021

EXHIBITOR INDEX

Functional Mind™ 9042

GAINSWave® ................................ 6026

Gameday Men’s Health ........................ 9122

GastroDefense 3105

Genova Diagnostics 6027

German – French Society for Thymus Therapy .... 1044

Ginger Allen .................................. 1022

Global Life Rejuvenation 4043

Glocal Lab, LLC. 7102

GlycanAge Ltd. ................................ 8080

Grand Ave Pharmacy .......................... 2085

H-Wave ..................................... 2129

Hair Science 3047

HairSmart Inc. ................................ 8098

Hallandale Pharmacy .......................... 5055

Halos ........................................ 5094

Harmony Care LLC 1047 & 8067

Hawaiian Moon ............................... 3095

Heads Up .................................... 8092

Health & Beauty Connection.................... 2114

Health Experts Alliance 3115

Healthgevity 8023

Hilltek ....................................... 8128

Holistic Care .................................. 1098

Hormone Therapy Centers of America 8039

Host Defense Mushrooms 9038

Hue Light USA ................................ 1056

Human Touch LLC ............................. 6092

Humann 9009 H-Wave 2129

Hydro Heal ................................... 2102

IASIS Technologies, Intl. ........................ 2043

Illuco USA 7093

IMAET Bioenergetic Technology 7038

Immunocine Cancer Center ..................... 6073

Immunosciences Lab, Inc. ...................... 1035

InBody 4099

Infiniwell 7079

Innergy Development, LLC ..................... 5061

Medical Marvel Massage Chairs, LLC 9027

Medical Tech ................................. 8072

MediVera Compounding Pharmacy .............. 2127

MediZap 8086

Med Results 7064

Medyca Cell - Medyca Bosques ................. 2119

menMD ...................................... 8125

Meridian Valley Lab 9090

Merit Pharmaceutical 4037

Metabolic Maintenance ........................ 7067

Metagenics ................................... 4085

MHC Medical Products ........................ 7127

Microbiome Labs 3009

miraDry, Inc. .................................. 7108

MitoQ ....................................... 7129

Mitozen Scientific ............................. 4091 Molecular You 8079

Molekule Air Purifiers .......................... 1091 Momentus ................................... 8124

Mosaic Diagnostics ............................ 2038

Multi Million Dollar Practice and Private Practice Freedom 2044

MyAdvice 9028

MyMycolab................................... 2061

MyPracticeConnect.com ....................... 1046

MyVitalC ..................................... 9098

N1o1 by Pneuma Nitric Oxide LLC 6033

National Hair Loss ............................. 8065

Natrusolate Americas Inc ....................... 9032

Natural Health Products LLC .................... 9128

NBX Wellness 6109

Neobiosis LLC ................................ 1037

NeuroScience - Sanesco ........................ 1064

Neuroveda Health ............................. 3103

Newbody Anti Aging

EXHIBITOR INDEX

PulsePEMF ................................... 1024

PurBlack 2108

Pure Encapsulations 3100

Purest Mushrooms ............................ 8127

PUR-FORM .................................. 5046

Push Patch 9020

Qest4 6039

Qualgen ...................................... 2117

Qualia ....................................... 6037

Qualiphy PC .................................. 3128

Quantum Biotechnology Corp 8112

Quartermaster Tax............................. 7042

Quest Diagnostics ............................. 6047

Quicksilver

Quintessence Biologics 2116

Qunol - Quten Research ....................... 7071

Rapid Release™ Technology ..................... 7098

Recharge Biomedical........................... 8090

Redd Remedies 7087

Redmond Real Salt 9116

ReeLabs Private Limited ........................ 6103

Refine USA ................................... 4078

Regen Pod 1030

Regenative Labs 4047

Regenere ..................................... 2047

REGENmax ................................... 2065

ReHealth 5071

Rejuvenation Science 4039

rekindlemed

8077

Relax Far Infrared Saunas ....................... 9041

Resbiotic Nutrition 6105

Researched Nutritionals 4013

Revelation Pharma ............................ 3085

.......................................

EXHIBITOR INDEX

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IT’S A GREAT OPTION TO HAVE RATHER THAN HAVING SURGERIES. IT’S GONNA HELP ANY ATHLETE AND SOMEBODY THAT IS ACTIVE. IF YOU WANT TO STAY ACTIVE AND YOU HAVE ACHES AND PAINS, REGENERATIVE MEDICINE WOULD BE MY FIRST CHOICE.

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SAFETY AND EFFICACY OF WHARTON’S JELLY CONNECTIVE TISSUE

ALLOGRAFT FOR ROTATOR CUFF TEARS: FINDINGS FROM A RETROSPECTIVE OBSERVATIONAL STUDY.

EXHIBITOR FLOOR PLAN

EXHIBITOR LISTINGS

10X Health System

2920 NE 207th St. Ste 901 Miami, Florida 33180

Ph: (844) 977-2810

Email: support@10xhealthsystem.com www.10xhealthsystem.com

10X Health is at the forefront of personalized precision wellness, empowering people everywhere to take control of their wellness. Using advanced precision wellness solutions powered by genetic and blood testing, we peel back the layers and uncover what your body needs to function optimally. Our mission redefines healthcare with a focus on anti-aging, wellness, and peak performance. Our groundbreaking Precision Nutrition System, the first patented global system, combines precision genetic testing, custom supplements, and personalized IVs tailored to each person.

3x4 Genetics

3120 139th Ave. Ste 500 Bellevue, Washington 98005 US

Ph:

Email: info@3x4genetics.com www.3x4genetics.com

We’re a genetics-based health technology company that combines advanced genetic testing, nutrigenomic education, and a global network of accredited practitioners to help people make sound, daily choices to live longer, healthier, and better lives.

Solutions

Ph: (561) 320-8111

Email: marketing@fyinstitute.com

www.4everyoungantiaging.com

4Ever Young was founded because we were willing to ask a radical question: what if you could look forward to the aging process? We’re in the business of helping you live your best life—no matter where you are in your journey. Our anti-aging health facility uses advanced diagnostic methods and modern anti-aging science to develop a customized plan for your specific experience and moment in your journey. We don’t just treat symptoms; we help you maintain vitality and wellness.

1801 N Military

Ph: (561) 997-0112

Email: info@a4m.com

www.a4m.com

Driven by a visionary mission to revolutionize healthcare, The American Academy of Anti-Aging Medicine (A4M) is the world’s leading provider of advanced medical education in functional, preventive, and longevity medicine. Through its diverse array of innovative learning opportunities, A4M equips forwardthinking practitioners with the expertise and tools to deliver personalized, whole-person care that optimizes health, vitality, and resilience at every stage of life.

AC Grace Company Booth #

Ph: (800) 833-4368

Email: info@acgrace.com

www.acgrace.com

Providing the Highest quality Products, Unique E “The Natural Choice” Since 1962

Accelerated Medical Practices Booth #9036

7505 West Sand Lake Road

Ph: (833) 222-2889

Email: info@acceleratedmedicalpractices.com www.acceleratedmedicalpractices.com

We are a hormone healthcare training and consulting company. We accelerate clinics who either want to open, add or re-energize hormones into their business. Our clients get training, resources and implementation in the 4 areas that are the most important for optimal success; Provider Support, Front and Back Office, Sales and Marketing. Our program has been tested and proven. We have done it for ourselves and have helped over 50 clinics. Please come meet us at our booth!

A4M Booth #5000

Access Medical Labs

Booth #5011

5151 Corporate Way

Jupiter, Florida 33458

Ph: (866) 720-8386

Email: info@accessmedlab.com www.accessmedlab.com

Access is the nation’s premier specialty diagnostic lab. We offer a broad menu of testing from blood, saliva, urine & swab samples. We perform all of your tests in our 25,000 sq. ft. ultra-automated facility in Jupiter, Florida & provide results within 24hrs. Since 2003, we continuously strive to innovate, inspire, and improve solutions for physicians by providing an exceptional personalized experience with the most accurate testing.

Acella Pharmaceuticals

Booth #3099

1880 McFarland Pkwy Ste 100 Alpharetta, Georgia 30004

Ph: (800) 541-4802

Email: info@acellapharma.com www.acellapharma.com

Acella Pharmaceuticals, LLC is a specialty pharmaceutical company committed to innovating the healthcare field by bringing quality and affordable products to our customers and patients.

Ageless Ambition Media

Booth #7125

8951 Bonita Beach Rd Ste 525 #261

Bonita Springs, Florida 34135

Ph: (515) 639-1878

Email: Support@AgelessAmbitionMedia.com www.agelessambitionmedia.com

Welcome to **Ageless Ambition Media**, where the art of branding meets the science of wellness. We specialize in transforming medical practices and wellness clinics into household names that speak to the heart of the health-conscious. We create brands that not only stand out and speak directly to those yearning for vitality—a practice with a digital presence so magnetic that potential patients can’t help but lean in. We are the digital storytellers guiding you into this longevity revolution.

Alight Health Formulas

4230 East Towne Blvd. Ste 327 Madison, Wisconsin 53704

Ph: (661) 425-2334

Email: contact@alighthealthformulas.com www.alighthealthformulas.com

Alight Health Formulas is dedicated to providing superior products to support those dealing with neuroinflammatory disorders such as mold illness, PANS/PANDAS and complex chronic illnesses. We believe that addressing environmental and infectious contributors to disease is one of the most essential and actionable steps in improving overall health. We’re passionate about providing practitioners with the tools they need to help their most sensitive patients.

Aligned Modern Health

Ph: (773) 598-4387

Email: info@alignedmodernhealth.com www.alignedmodernhealth.com

Aligned Modern Health is a leading lifestyle medicine brand with 18 clinics across Chicagoland. Our inclinic and virtual Lifestyle Medicine Doctors provide outstanding clinical outcomes and patient experiences using modern diagnostic testing and nutritional science to correct imbalances and treat chronic disease. They work closely with Chiropractic Physicians, Massage Therapists, and Acupuncturists in a multidisciplinary, evidence-based model that offers solutions to musculoskeletal pain, hormone issues, stress/anxiety, autoimmunity, GI distress, infertility, and more.

Allergy Research Group

#5079

650 South 500 West Ste 330

Ph: (800) 545-9960

Email: info@allergyresearchgroup.com www.allergyresearchgroup.com

For 45 years, Allergy Research Group has supported healthcare practitioners and their patients with the tools necessary to achieve the confidence that comes from great health. Our dedication to creating clinically sound, evidence-based, condition-specific formulas using clean, hypoallergenic ingredients is unsurpassed—and it’s why our supplements are so widely trusted and well-tolerated by both practitioners and patients worldwide. By offering innovative solutions backed by science, we empower healthcare providers to improve the health and confidence of every patient. Visit us: allergyresearchgroup.com

Alletess Medical Laboratory

Booth #9013

14 Howard Street

Rockland, Massachusetts 02370

Ph: (800) 225-5404

Email: alletess@foodallergy.com www.foodallergy.com

Founded in 1980, Alletess Medical Laboratory has been providing allergy and immunology testing services to clinicians worldwide. Our highly knowledgeable staff, cutting-edge medical technology, and customized wellness programs allow us to provide high-quality laboratory testing and services to our clients. We understand that test results impact patient lives, every day we strive to provide test results with actionable information to clinicians to improve patient’s health and quality of life. The test result is the beginning of the journey.

Alliance for Pharmacy Compounding

Booth #9124

100 Daingerfield Rd Ste 100 Alexandria, Virginia 22314

Ph: (281) 933-8400

Email: info@a4pc.org www.a4pc.org

The Alliance for Pharmacy Compounding is the voice for pharmacy compounding, representing compounding pharmacists and technicians in both 503A and 503B settings, as well as prescribers, educators, students, researchers, and suppliers. Compounding exists for those who are not served by traditional pharmaceutical manufacturers. APC members play a critical role in patients’ lives, creating essential medications unavailable elsewhere for a range of health conditions, including autism, oncology, dermatology, ophthalmology, pediatrics, women’s health, animal health, and others.

American Cell Technology

Booth

#7066

13794 NW 4th Street Ste 212

Sunrise, Florida 33325

Ph: (201) 248-5177

Email: info@americancelltechnology.com

www.americancelltechnology.com

American Cell Technology provides leading edge personal stem cell banking services to collect, process, grow and store adult and newborn autologous Mesenchymal Stem Cells (your own MSCs) for potential future medical or regenerative use as determined by you and your personal physician.

American Herbal Labs & Nano

Herbs Light

Booth #4038

8526 E. Garvey Ave

Rosemead, California 91770

Ph: (626) 307-0928

Email: dr.luke@newvita.com www.newvita.com

We offer a simple & effective system which is Artificial Intelligence in Chinese Medicine® to take care 700 conditions, and slow down the aging process including AI, nanotechnology, and Stem Cell Booster ™ technology. It includes Meridian Energy Analysis, Nano Herbs®, Nano Vita® Water and acupuncture without needles---Nano Herbs® Light. One-day training class, book “CHINESE MEDICINE MADE SIMPLE” are available. Dr. Luke Cua will provide TCM service on site.

American Wellness Pharmacy

Booth #7103

2725 S. Jones Blvd. Ste 100A Las Vegas, Nevada 89146 US

Ph: (702) 405-9500

Email: info@americanwellnesspharmacy.com www.americanwellnesspharmacy.com

We are deeply committed to our community, offering unmatched compounding services, as reflected by our PCCA and IACP memberships. We specialize in Bio-Identical Hormone Replacement, Women’s Health, Sexual Health, Pain Management compounding, peptides, longevity medications among other areas. Our staff is extensively trained in both sterile and nonsterile compounding techniques and benefits from a support network that fosters innovation through our PCCA membership. Our goal is to provide high-quality compounded medications at competitive prices.

AnazaoHealth

Booth

#3055

5710 Hoover Blvd Tampa, Florida 33634 US

Ph: (800) 995-4363

Email: emarketing@anazaohealth.com www.anazaohealth.com

AnazaoHealth is a national specialty compounding pharmacy. With a 30,000-square-foot 503B FDARegistered Outsourcing Facility in Las Vegas and a 46,000-square-foot traditional 503A compounding pharmacy in Tampa. Both facilities have the appropriate licensure to conduct business in most states, the District of Columbia, and selected U.S. territories. AnazaoHealth compounds preparations for Aesthetics, Age Management, Weight Management, IV & Injection Therapy Solutions, Sexual Wellness Solutions, Hormone Replacement, Personalized Hair Care Solutions, Mental Clarity & Acuity and more.

Ancient Nutrition

Booth #7123

2000 Mallory Ln Ste 130-137 Franklin, Tennessee 37067

Ph: (920) 901-6148

Email: deb.bruckschen@ancientnutrition.com www.ancientnutrition.com

At Ancient Nutrition, we have a clear goal: harness history’s most powerful superfoods to help fill the gaps in the everyday diet. But who we are goes beyond supplements. We embrace our responsibility to our planet by leading the revolution of regenerative agriculture. We’re dedicated to forward-thinking methods that foster richer soil, cleaner air, and, ultimately, healthier ingredients. Through regenerative methods, we can create supplements with the power to transform your health. We can save the world with superfoods.

Apex Energetics

Booth #4045

16592 Hale Ave. Irvine, California 92606

Ph: (800) 736-4381

Email: info@apexenergetics.com www.apexenergetics.com

Our motto—Patient Health First™—reflects our mission. It is also our guiding principle that dictates all decisions, from raw material acquisition to manufacturing to our strong practitioner relationships. Over the past 30+ years, we have built a reputation of integrity by infusing everything we do with this principle, and we remain at the forefront of Functional Medicine discoveries and advances with formulations spearheaded by Datis Kharrazian PhD, DHSc, DC, MS, MMSc, FACN.

Arete Regenerative Technologies

Booth

#3062

224 S. Main Street Ste 107

Springville, Utah 84663

Ph: (801) 376-9423

Email: sales@joinsoftwave.com www.joinsoftwave.com

SoftWave TRT, LLC is a medical technology company that is developing advanced solutions specializing in shockwave therapy for better patient healing. _Founded in 2004 with Corporate Headquarters in Alpharetta, GA, SoftWave TRT is committed to the scientific advancement of tissue healing and regeneration and the development of the most effective innovations to improve the quality of lives globally. German-engineered with superior quality, it is used worldwide in the healthcare fields of orthopedics, traumatology, wound care, aesthetics, and urology.

Argentyn 23 & Sovereign Copper Booth #7061

7504 Pennsylvania Ave Sarasota, Florida 34243

Ph: (941) 702-6100 x303

Email: ordersteam@n-icorp.com www.argentyn23.com

Since its launch in 2001, thousands of clinics worldwide have chosen Argentyn 23 Bio-Active Silver Hydrosol™ and First Aid Gel. Argentyn 23 is produced through a proprietary manufacturing technique that results in the smallest particles achievable with greater than 98% positively charged bio-active silver ions and silver nanoclusters. Visit us at our booth to learn more about you can harness the power of silver and copper, our newest hydrosol, in your practice.

Aura Wellness Booth #8118

Ph: (502) 576-9961

Email: Sales@aurawell.com

www.aurawell.com

Aura Wellness is dedicated to enhancing your overall wellness through the power of PEMF (Pulsed Electromagnetic Field) therapy. Our mission is to help you achieve optimal health and vitality by harnessing the natural benefits of PEMF.

Auro Wellness

Booth #1027

520 W. La Habra Blvd. La Habra, California 90631

Ph: (562) 691-6754

Email: info@aurowellness.com

www.aurowellness.com

Auro Wellness is deeply committed to research and innovation. Following 14 years of intensive rigorous testing, Glutaryl was introduced featuring a fusion of Auro’s multi-patented sub-nano absorption technology and key ingredient, Glutathione. Glutaryl™ stands as the pioneering topical glutathione product capable of providing systemic benefits through skin absorption. Auro Skincare is a protocol of potent antioxidant formulas powered by the patented technology to deliver pharmaceutical grade ingredients to the inner layers of the skin.

AVACEN, Inc

Booth #9043

2365 Camino Vida Robles Unit C

Carlsbad, California 92009

Ph: (888) 428-2236

Email: djforsgren@avacen.com www.avacen.com

AVACEN uses the AVACEN Treatment Method (ATM) –noninvasive pain management technology platform for adding heat to the palm, gently expanding the volume of blood in the palm’s unique vascular networks while heat is simultaneously transferred from the computer managed palm pad into these expanded vascular networks. FDA Class 11, OTC for aches, pains, strains, overall muscular relaxation and widespread pain for arthritis. We also have a GSA contract for the VA.

AYUMETRIX

Booth #6046

17387 163rd Ave

Lake Oswego, Oregon 97035

Ph: (503) 344-1344

Email: skapur@ayumetrix.com www.ayumetrix.com

AYUMETRIX is a “smart lab of the future” and has been founded to empower individuals to take charge of their health and wellness using innovative sample collection and laboratory testing technologies. It is a global hormone testing laboratory that partners with clinicians all around the world and offers a practice building package that is inclusive of integrative and functional laboratory testing services, personal health data acquisition/ analysisall under the guidance from industry experts.

Ayush Herbs Inc.

Booth #

3079

2239 152nd Ave. NE

Redmond, Washington 98052

Ph: (425) 637-1400

Email: pamelap@ayush.com www.ayush.com

Ayush Herbs, Inc. was founded in 1988 by Ayurvedic and Naturopathic physicians who believe in healthy living in body, mind and spirit. High quality, organic herbs and years of Ayurvedic wisdom have culminated into a company with a mission of education and creating trusted formulas. Ayush Herbs® is a name that represents quality and purity; for the sake of our customers, our families, and the Ayurvedic community.

Bales Photonics, Inc.

4919 Whitehaven Way

San Diego, California 92110

Ph: (619) 886-5580

Email: info@balesphotonics.com www.balesphotonics.com

Bales Photonic’s vision is to bring Photobiomodulation (PBM) light therapy to the masses via the availability of a powerful, effective, and affordable product line. Firefly Multi-Spectral Light Therapy can address a multitude of these health and wellness issues and concerns from pain and even daily functioning deficits, all thru safe and reliable PBM without toxins. Firefly light therapy truly is part of the future of medicine.

Bare Compounding Pharmacy Booth #3093

1300 East Bidwell St. Ste 105 Folsom, California 95630 US

Ph: (916) 983-4900

Email: support@barecompounding.com www.barecompounding.com/

Bare Compounding Pharmacy, California’s trusted source for personalized medications and highquality supplements since 2007. We ensure our compounded medications meet the highest industry standards with a “BARE” approach to formulating minimalistic compounds. We offer bio-identical hormone replacement therapy, personalized pet medications, Semaglutide, testosterone for men and women, thyroid hormone capsules, LDN capsules, ketamine troches, and more, all at affordable prices.

Beauty

and Health from Within, LLC

Inlet Way

Ph: (561) 350-0096

Email: info@effectivecollagen.com

Beauty and Health from Within, LLC is a wellness consulting company dedicated to empowering individuals to achieve optimal health and beauty through holistic and science-based approaches. Specializing in functional nutrition, biohacking, and personalized coaching, We provide innovative strategies to enhance vitality, manage weight, and promote youthful aging. Our mission is to inspire lasting lifestyle transformations that foster both inner health and external radiance.

Bella Vita Trading Co.

Booth #9049

762650 Fred Waring Dr. Ste 206 Palm Desert, California 92260

Ph: (760) 774-6877

Email: mwilliams@bellavitatc.com www.bellavitaclinics.com

BellaVita offers expert hormone optimization, training, and top-tier patient care tools.

Benilight

Booth #7116

15 Naeyuri 1 gil Ipjanmyeon Seobuggu Cheonan, Ch’ungch’ong-namdo 31027 ROK

Ph: (8)(241)-583-1365

Email: benilight@benilight.com www.benilight.com

Benilight has developed LED healthcare products and LED photobiomodulation (PBM) therapy medical devices. Our devices have been registered as US FDA class 2 medical devices for pain relief and blood circulation improvement. Recently, we developed Half-Body LED PBM device, which is controlled by AI powered APP. Our devices are now being exported to the United States, Australia, Japan and UAE.

Berkeley Life

Booth #4092

355 East Ohio St. Ste 200 Chicago, Illinois 60661

Ph: (773) 750-7745

Email: info@berkeleylife.com www.berkeleylife.com

Berkeley Life Professional’s Nitric Oxide Support products are used by top practitioners around the country. Nitric Oxide is produced naturally by your body. It’s responsible for promoting artery vasodilation which relaxes the muscles in your blood vessels allowing for healthy blood flow and circulation. Berkeley Life’s Nitric Oxide support products include a Dietary Nitrate Supplement, patented Test Strips. Used together, this system provides tools for assessing and supporting Nitric Oxide levels from head to toe.

Best 365 Labs, Inc.

2722 S. West Temple Salt Lake, Utah 84115

Ph: (385) 421-5651

Email: sales@best365labs.com www.best365labs.com

Best 365 Labs emphasizes the importance of mitochondrial health for overall vitality. They develop pharmaceutical-grade Methylene Blue products to support healthy memory, brain function, and mitochondrial health. Best 365 Labs product development is guided by: Using pharmaceutical-grade Methylene Blue and other specific nutrients. Employing various applications and delivery mechanisms. Offering clinically-tested, IP-protected formulations. Focusing on affordability and effectiveness.

Beyond Remission

E. Hampden Ave. Ste 352

Ph: (970) 851-8370

Email: info@beyond-remission.com www.beyond-remission.com

Beyond Remission is a self-guided online educational program based on 18 years of application. Our program allows a patient to permanently heal chronic illness and autoimmune disease without medication, supplements, food diets, bloodwork, or mind-body interventions in 6 months or less. Come visit our booth, learn about the future of medicine: Emotional Medicine, and find out how we have a 100% success rate by working on the internal emotional state of our students.

BHI Therapeutic Sciences

Booth #8126

214 State Street Ste 101 Hackensack, New Jersey 07601 US

Ph: (212) 206-7073

Email: bmehling@bluehorizoninternational.com www.bluehorizoninternational.com

BHI Therapeutic Services was formed with the mission to advance stem cell research in full regulatory conformance and in conjunction with the scientific community, while making stem cell therapy available and affordable to those suffering from disease and injury. The team includes US board-certified physicians and an experienced Scientific Advisory Board to oversee the disease-specific protocols to ensure the highest standards of patient safety. BHI Therapeutic Services leads innovation and improvements in regenerative medicine across the globe.

Bimini NanoJet Oxygen Plunge

Booth #2122

11101 Cutten Rd Ste 100

Houston, Texas 77066

Ph: (346) 355-7940

Email: contact@biminihydrotherapy.com www.biminihydrotherapy.com

Welcome to the Bimini Revolution! Experience the transformative Bimini Oxygen Plunge, featuring patented NanoJet technology that generates ultrafine Oxygen Nanobubbles, 2,500x smaller than pores. Soaking in our warm water enhances oxygen absorption, boosting overall wellness by reducing inflammation, managing pain, aiding recovery, stimulating brain activity, improving memory, increasing energy, and detoxifying blood. Our mission is to empower individuals to enhance their quality of life. Visit our booth to discover how the Bimini Oxygen Plunge can rejuvenate health and elevate lifestyles!

Biocanic, Inc.

Booth #2063

4967 Foothill Blvd. San Diego, California 92109

Ph: (619) 867-2318

Email: jeremy@biocanic.com www.biocanic.com

Biocanic is the first of its kind health program intelligence system specifically designed to streamline personalized health programs for functional and integrative health practitioners. Biocanic helps you more effectively design, build and implement personalized health programs for your clients.

Biocidin Botanicals™

Booth

#4033

16 Hanger Way Ste A

Watsonville, California 95076

Ph: (843) 813-5833

Email: bbrevents@biocidin.com www.biocidin.com

Biocidin Botanicals™ is a leader in botanical supplements and a pioneer in the arena of microbiome health. Its flagship broad-spectrum botanical blend Biocidin® was formulated in 1989 in response to challenging health conditions related to microbial imbalances. More than 30 years later, the company offers a curated line of targeted support products to boost patient health and target the entire GI tract and oral cavity, supporting microbiome balance for healthy digestion and elimination.

Bioclinic

Naturals

Booth #9033

3655 Bonneville Place

Burnaby, British Columbia V3N 4S9

Ph: (877) 433-9860

Email: customersupport@bioclinicnaturals.com www.bioclinicnaturals.com

Bioclinic Naturals® is a Canadian nutraceutical manufacturer of a professional product line comprised of fertility kits and supplements, Essential Fatty Acids, mitochondrial support, detox support, PCOS support, and natural stress and sleep aids. Our goal is to provide the best quality, tested, raw materials. Whenever possible we grow our own plant-based ingredients and any raw material we do not produce ourselves is subjected to the highest level of scrutiny to ensure the quality and purity.

BIOLabs PRO®

Booth #3116

4525 Cove Dr #15

Carlsbad, California 92008

Ph: (760) 297-6942

Email: partner@biolabspro.com www.biolabspro.com

BIOLabs PRO® was founded with a clear mission: Smarter Health & Aging™. At BIOLabs PRO®, we develop doctor-recommended, maximum strength products for easy at-home age management. Focusing on transdermal bio-identical hormone containing products and supplements, we believe these solutions are key to supporting longevity and a healthier future. As trusted partners to integrative health professionals, we offer private label and custom over-the-counter products, providing expertise from formula development to shelf-ready topical cosmetic creams and oils.

BioProtein Technology

Booth #3043

6702 Benjamin Rd. Ste 500 Tampa, Florida 33634 US

Ph: (800) 280-2456

Email: info@bioproteintech.com www.bioproteintech.com

BioProtein Technology is the home of BioPro+, the first of its kind Bioidentical alternative to synthetic HGH - Growth Hormone treatments. Since 2009 BioProtein Technology has been providing physicians and their patients cutting edge alternatives to the industry’s most common pharmaceutical anti-aging and regenerative drugs. Whether its hormones, weight loss, libido, or sleep & stress, BioProtein Technology has a non-synthetic alternative that works faster, is easier to use, and 100% safe.

Biotics Research

Booth #1015

5245 Business Park Drive

Rosenberg, Texas 77469

Ph: (800) 231-5777

Email: biotics@bioticsresearch.com www.bioticsresearch.com

Biotics Research has been a leader in the nutrition industry for over 48 years. Known for top-quality supplements and enhanced product delivery systems, the company drives advancement by focusing on research initiatives, unique product formulations and unprecedented quality control. A family-owned company with a rich history, Biotics Research is most proud of their valued partnerships with healthcare professionals.1-800-231-5777 www.bioticsresearch.com

BluePrint Advertising Agency Booth #7110

15705 W. Dodge Rd Ste 101 Omaha, Nebraska 68118

Ph: (402) 669-9661

Email: info@BluePrintAdAgency.com www.blueprintadagency.com

BluePrint Advertising Agency designs and builds innovative marketing and advertising campaigns based on our clients’ goals and expectations. We individualize all of our campaigns to make your advertising yield more effective results. We provide marketing strategies and expertise to ensure our clients get the most for their advertising dollars. At BluePrint Advertising Agency, our central priority is delivering results that drive success and the overall satisfaction of our clients.

BodyK Booth #2101

101 W Main Street Ste 101 Norfolk, Virginia 23510

Ph: (917) 608-2816

Email: matt@bodyk.net www.bodyk.net

Our technology performs a non-invasive screening which produces more than 30 key biomarkers. Our AI software uses the latest peer-reviewed research to analyze the client’s biomarkers and recommend diet, supplement, and lifestyle changes to improve their health. Adding a machine to your practice can add up to $250,000 of incremental revenue per year while providing your clients with key insights to their health.

BodySite

Booth

#5091

230 N. Congress Avenue Bay A12 Lake Park, Florida 33403

Ph: (561) 247-3839

Email: info@bodysite.com www.bodysite.com

Automate patient education and care between encounters. Our integrated web platform and mobile app has everything you need to easily improve patient outcomes and scale your practice. Our customizable care plans provide automated patient education and lifestyle guidance for everyday. Remotely monitor patient progress and communicate with HIPAA-compliant messaging and telemedicine. Easily schedule and charge for programs, virtual meetings and more. Powerful features. Turnkey Solution. Branded for your practice.

Bone Index Finland Ltd.

Booth

#9025

Savilahdentie 14 Kuopio, Pohjois-Savo FI08 70700 FI

Ph:

Email: info@boneindex.com

www.bindex.us

Bone Index provides handheld Bindex device for osteoporosis diagnostics. Bindex scan is fast, easy and safe ultrasound based measurement for bone density, and can be offered in any situation. Bindex provides evidence based clinically accurate results, backed by published data, and has been widely used with over 4 million bone density measurements provided for US citizens. The mobility and reliability of the method offer real value for the consumers and also credible business opportunities for the preventive health care providers.

Boston Heart Diagnostics

Booth #5044

200 Crossing Blvd

Framingham, Massachusetts 01702 US

Ph: (877) 425-1252

Email: customercare@bostonheart.eurofinsus. com

www.bostonheartdiagnostics.com

Boston Heart Diagnostics is transforming the treatment of cardiovascular and related diseases through novel clinical diagnostics, therapeutically focused reports, and personalized, scientifically designed nutrition and lifestyle programs that have the power to change the way healthcare providers and patients communicate about heart health.

Revitalize your Body from the Inside Out with Total Brain & Body O2 IHHT Therapy

Discover the power of Total Brain & Body O2 IHHT, a revolutionary therapy designed to promote cellular healing and enhance mitochondrial function.

As we age, the body’s ability to regenerate declines, leading to fatigue, cognitive decline, and decreased vitality.

IHHT combats this by alternating between oxygen-rich and oxygen-deprived phases, which optimizes oxygen utilization and triggers cellular rejuvenation.

Through this process,your body naturally removes damaged cells, promotes the growth of new capillaries,and restores mitochondrial eﬃciency, the key to increased energy, improved brain function, and overall longevity.

Key Beneﬁts

Enhanced Cellular Therapy Mitochondrial Renewal Increased Oxygen Utilization

Stimulates cell repair and regeneration, rejuvinating tissues and organs for long-term vitaltity.

Supports the removal of damaged mitochondria (mitophagy) and enhances mitochondrial function, essential for energy production and anti-aging.

Facilitates new capillary formation (angiogenesis) to improve blood ﬂow and oxygen delivery, reaching areas where it’s needed most.

Experience the future of anti-aging with Total Brain & Body O2 IHHT Therapy. Call us or scan the QR code to recieve your free copy of our ‘Breathe New Life into Your Practice’ Booklet and discover how to integrate this advanced therapy into your clinic to help your patients achieve cellular rejuvination and a more youthful, energized life.

The only glutathione that checks all the boxes

Backed by peer-reviewed, published clinical research

28% increase in red blood cell glutathione levels

400% increase in natural killer cell function

25% reduction in oxidative stress* Shelf stable at room temperature - no refrigeration required

BrainMaster Technologies, Inc.

Booth

#2075

195 Willis St.

Bedford, Ohio 44146

Ph: (440) 232-6000

Email: sales@brainm.com

www.brainmaster.com

BrainMaster offers the most cutting edge and comprehensive variety of Clinical EEG, 3D Brain Imaging, qEEG and Neurofeedback on the market. Application areas include real-time imaging utilizing sLORETA as well as the newly released xLORETA, normative databases and pre/post therapeutic comparison. Clinical and personal database driven Neurofeedback, biofeedback, peak-performance, research, VR and brain-controlled systems. Partner with us, and help us change lives, one brain at a time!

BrainTap

Booth #4071

2861 Trent Rd.

New Bern, North Carolina 28562

Ph: (914) 329-9152

Email: sales@braintap.com www.braintap.com

BrainTap, the Brain Fitness Company, provides a mobile app and optional headset that strengthens your brain. Our scientifically proven products are effortless to use and provide significant benefits in just 15 minutes. . Our friendly technology empowers you to think, sleep, and perform better, improving every area of your life, including the ability to better handle life’s stress. With over 2000 unique audio sessions, we created BrainTap to address the most important focused life outcomes.

Brand Better

Booth #3122

2102 Kimberton Rd. Unit 472

Kimberton, Pennsylvania 19442

Ph: (267) 217-3499

Email: support@brandbetterco.com

www.brandbetterco.com

We are a branding and marketing agency for doctors in private practice, wellness brands, health clinics and clinician entrepreneurs. At Brand Better® we are an award-winning agency, known for transforming health brands from cookie-cutter and basic - to polished, professional and personality-driven. As your one-stop-shop for building a brand as a doctor, you can work with our team on brand identity, copywriting, web design, marketing strategy, developing online programs, sales funnels, social media management and podcast production.

W. Springfield

Ph: (425) 736-5723

Email: info@broadcastyourauthority.com www.broadcastyourauthority.com

Propel your podcast to new levels with our bespoke Done-For-You Solution. Specializing in turning content into meaningful connections, we target and captivate your ideal audience across all platforms. Collaborate with a partner that’s more than a production service; we’re your strategic ally in marketing, and booking agency offering a comprehensive growth plan committed to elevating your brand’s presence. Join the ranks of hundreds of podcasts benefiting weekly from our expertise. Let’s amplify your voice and accelerate your success together.

BTL Industries, Inc

Booth #8064

362 Elm Street

Marlboro, Massachusetts 01752

Ph: (866) 285-1656

Email: info@btlnet.com www.bodybybtl.com

Founded in 1993, BTL has revolutionized the way to offer the most advanced non-invasive solutions for body-shaping, skin-tightening & other medical aesthetic treatments, including women’s intimate health and wellness. BTL’s brands include EMSCULPT NEO®, EMFACE®, EMSCULPT®, EMSELLA®, EMTONE™, EMFEMME 360™, BTL Exilis ULTRA™. Additional information can be found at www.bodybybtl.com.

BWH Labs

Booth #3045

1000 Cobb Pl Blvd NW Ste 407 Kennesaw, Georgia 30144

Ph: (855) 504-5005

Email: support@bwhlabs.com www.bwhlabs.com

Your trusted partner for Immune Health and Longevity since 1999. With our flagship product, Beta Glucan, we empower you and your clients to achieve the strongest Immune System Possible.

C60 Shop, Inc.

Booth #3118

4845 Pearl E. Circle Ste 101 Boulder, Colorado 80301

Ph: (303) 588-8608

Email: partnerships@shopc60.com www.shopc60.com

C60 Power products are the highest potency and highest purity Carbon 60 based antioxidants available. 99.99% Pure Sublimated C60 and all ORGANIC ingredients are used in all of our products. C60 Power is the BEST OF THE BEST.

Calroy Health Sciences

Booth

#4026

14362 N Frank Lloyd Wright Ste 1000 Scottsdale, Arizona 85260

Ph: (800) 609-6409

Email: support@calroy.com

www.calroy.com

Advancing Science. Enhancing Health. At Calroy, we translate breakthrough science into products without parallel. Through rigorous research and formulation, we develop transformative new solutions for health. Our team leads emerging scientific research, applies expertise on world-class natural ingredients, and then conducts formulationspecific research to optimize outcomes. The result is a highly focused approach, including the only dietary supplement patented to regress vulnerable plaque - Arterosil HP - and a revolutionary, longlasting nitric oxide supplement - Vascanox HP.

Calmoseptine, Inc.

Booth #4105

16602 Burke Lane

Huntington Beach, California 92647

Ph: (714) 840-3405

Email: Greg Dixon www.calmoseptineointment.com

Calmoseptine Inc. markets Calmoseptine Ointment in all 50 states, Canada, United Arab Emirates, Jordan, Cuba, Peru, and Chili. Calmoseptine Ointment is an effective, multi-purpose moisture barrier that protects and helps heal skin irritations. Calmoseptine Ointment is available in 2.5-oz jars or tubes, 4-oz tubes, 1/8-oz packets, and 20g tubes through most wholesalers, distributors and pharmacies. For more information, please call us at 800-800-3405, e-mail us at info@ calmoseptine.com, or visit www.calmoseptine.com.

Calocurb Limited

Booth

#3081

17B Farnham Street, Ste 13517

Auckland, Auckland 01052

Ph: (833) 225-2872

Email: hello@calocurb.com www.wholesale.calocurb.com

Calocurb is a revolutionary appetite suppressant that harnesses the power of GLP-1 activation to naturally curb hunger and support dietary management. Scientifically developed and rooted in research, our product empowers individuals to control their eating habits effectively. Committed to customer success, Calocurb simplifies the journey towards a healthier lifestyle, helping you achieve and maintain your health goals with integrity and simplicity.

Canada RNA Biochemical Inc

Booth #4048

4400 Hazelbridge Way Unit 680 Richmond, British Columbia V6X 3R8 CA

Ph: (604) 273-2233

Email: info@canadarna.com www.canadarna.com

We specialize in niche natural medicine for practitioners, and are best known for our product Boluoke (lumbrokinase). It is the most potent and research-backed oral fibrinolytic agent with over 30 years of safe and effective clinical usage. It is applicable for situations associated with a hypercoagulable blood state. Please stop by our booth to sign up for a FREE coagulation health check ($105 value)! Only 30 spots available.

Cancer Check Labs

Booth #3102

1303 Medical District Dr. Dallas, Texas 75207 US

Ph: (214) 301-0351

Email: info@cancerchecklabs.com www.cancerchecklabs.com

Cancer Check Labs (CCL) can detect 200+ solid tumor cancers and has detected Stage 0 cancer from a blood sample. Unlike other cancer screening tests, CCL uniquely extracts whole, intact tumor cells from a blood sample to enable their physical examination by a Board Certified Pathologist. Pathology review of tissue samples is the gold standard for solid tumor cancer detection today. Because CCL follows established, conventional tissue-based pathology standards, CCL can provide highly accurate cancer screenings.

Candela Medical

Booth #3060

251 Locke Dr

Marlborough, Massachusetts 01752

Ph: (800) 733-8550

Email: marketing.na@candelamedical.com www.candelamedical.com/na

Candela is a leading global energy-based, device company with a comprehensive product portfolio and global distribution footprint in over 100 countries. With hundreds of patents issued, we’re dedicated to the development of innovative products that allow treatment providers to offer advanced solutions for a broad range of medical aesthetic applications.

Canfield Scientific

Booth #6048

4 Wood Hollow Road

Parsippany, New Jersey 07054

Ph: (973) 434-1200

Email: info@canfieldsci.com www.canfieldsci.com

Canfield Scientific is the global leader in imaging systems, services and products for medical and skin care industries, scientific research, and healthcare applications. For over 35 years Canfield has been the premier worldwide supplier of digital photographic systems, imaging software, and associated support services. Our solutions aid professionals in improving patient communications and managing treatment outcomes. Built around a common patient image chart, all of our imaging systems are fully integrated to streamline your workflow.

CardieX

Booth #7073

184 Shuman Blvd Ste 515

Naperville, Illinois 60563

Ph: (505) 427-1918

Email: tchilds@cardiex.com www.cardiex.com

Cardiex is redefining the way hypertension, cardiovascular disease, and other major vascular diseases are clinically diagnosed and managed. Our pioneering SphygmoCor vascular biosensing technology measures arterial health by collecting clinically meaningful digital vascular biomarkers using novel sensors. These biomarkers represent key indicators of cardiovascular health including, but not limited to, central blood pressures, vascular stiffness, vascular age, and heart stress. SphygmoCor has been deployed in multiple clinical trials sponsored by pharmaceutical companies and healthcare systems to measure arterial health.

Cardio Vision Care MP

Booth

#2091

6999-2 Merrill Rd. Ste 120 Jacksonville, Florida 32277

Ph: (904) 846-7070

Email: info@cardiovisioncare.com www.cardiovisioncare.com

Cardio Vision Care MP is proud to join A4M again to introduce The Multifunction Cardiogram™ (MCG) Ten Minute Heart Scan! The Multifunction Cardiogram™ is FDA approved and has been used to test over 2M patients worldwide. With AI technology, the MCG™ gets smarter every time a test is run. It is the most comprehensive and accurate heart test available. Early Prevention in ten minutes come visit our booth at 2091 to learn more and to meet our amazing heart Team!

CAROL Bike

Booth #9091

167 City Road London, England EC1V 1AW UK

Ph:

Email: info@carolbike.com www.carolbike.com

CAROL Bike gives you the shortest, most effective workouts—proven to deliver superior health and fitness benefits in 90% less time compared to regular cardio. CAROL’s AI-personalized workouts are easy to follow, suitable for any age and fitness level, and create the most potent training stimulus with just 2x20-second sprints. It’s a moment of effort you can always master to build a habit that lasts.

CasaPharmaRX

Booth #3124

12855 Capricorn St. Stafford, Texas 77477 US

Ph: (833) 462-1919

Email: admin@casaphararx.com www.casapharmarx.com

At Casa Pharma RX, we provide high-quality compounded pharmaceuticals tailored to meet your unique needs. As a licensed sterile compounding pharmacy, we specialize in creating custom formulations that support your wellness journey. Our team of experienced pharmacists and technicians adhere to strict quality standards to ensure the safety and efficacy of our products.

Cell Surgical Network

Booth #1040

73700 Dinah Shore Drive Ste.301 Palm Desert, California 92211

Ph: (760) 424-8263

Email: sean@cellsurgicalnetwork.com www.cellsurgicalnetwork.com

Cell Surgical Network provides physicians technology that automatically isolates their patients’ adipose derived stem cells for regenerative purposes. CSN prevailed in a landmark federal court case against the FDA, allowing their use of personal stem cells isolated from adipose (fat) tissue. This ruling will allow doctors to continue the practice of medicine and provide potentially healing stem cells to their patients, while systematically collecting outcome data along with CSN’s over 500 international physicians.

Cellcore Biosciences

Booth

#2035

3405 East Overland Rd Ste 360 Meridian, Idaho 83642

Ph: (866) 902-1525

Email: support@cellcore.com www.cellcore.com

CellCore Biosciences provides supplements that address the underlying issues that may be impacting your patient’s health, such as toxins, pathogens, or infections. By supporting mitochondrial energy, proper drainage and detoxification processes, we achieve optimal organ function. As a result, the patient’s body is better prepared for further treatment if necessary. With BioActive Carbon - a proprietary blend of fulvic acids, CellCore products help bind, protect and deliver nutrients to the body.

Central Drugs Compounding Pharmacy

Booth

#1027

520 W. La Habra Blvd. La Habra, California 90631

Ph: (562) 691-6754

Email: clinicalrph@centraldrugsrx.com www.centraldrugsrx.com

Central Drugs is an industry leader in the art and science of custom compounding and individualized health-care solutions with a team of expert pharmacists at our state-of-the-art 503A compounding pharmacy. Central Drugs is your pharmacy partner, working with clinics to provide resources, education, and services to improve the overall health of your patients. Central Drugs specializes in compounding, seeking the most innovative, effective and trending formulations to meet the needs of clinics across 30 states.

Centropix

Booth #8034

271 Bell Street

Chagrin Falls, Ohio 44022

Ph: (216) 402-4121

Email: jencabic@gmail.com www.centropix.us/bluebitsllc

Centropix is the newest bio-tech company with the latest groundbreaking, patented products in the sectors of electromagnetic field and frequency applications. The Kloud is mathematically undisputed as the No. 1 Molecular Activator and 50 times greater in molecular activation capability than anything currently on the market. Active molecules means pure life energy. The wearable B2 wellness technology integrates earth’s resonance frequencies and natural magnetic field conditions (Schumann frequency/field). It is also customizable daily for your individual frequency needs.

Cerbo

Booth #4103

350 SE Mill St. Ste 11 Portland, Oregon 97214

Ph: (541) 391-4600

Email: sales@cer.bo

www.cer.bo

Cerbo is used by 1000’s of functional and integrative medicine, direct primary care, or cash-based practitioners. Our customers come to us when they are setting up a new practice or have been struggling with their current EHR solution. Created and designed by a busy medical practice, Cerbo is packed with features to make your life easier, so you can spend more time caring for your patients – and yourself!

Chi’s Enterprises Inc.

Booth #5042

1435 N. Brasher Street Anaheim, California 92807

Ph: (714) 777-1542

Email: chimailing@gmail.com www.chi-health.com

Chi’s Enterprise, 38 years in market, offers supplements including MYOMIN, an aromatase reducer. Jonathan Wright, MD and other doctors recommend Myomin to reduce estradiol/estrone, increase testosterone for men/women including BHRT users. Research Genetic Cancer Center (RGCC) highly recommends ANGIOSTOP for inhibiting angiogenesis factors, inhibiting signal transduction pathways, inducing caspases for apoptosis. VEINLITE- CVD, reduces D-Dimer. OXYPOWER- hypoxia, excellent for lung, heart, energy. BAMBOO EXTRACT, excellent for COVID-19. LIVER CHI induces interferon for hepatitis. KIDNEYCHI for UTI and prevent sexual disease.

Chilly GOAT Cold Tubs by Master Spas

Booth #8117

7102 Lincoln Parkway

Fort Wayne, Indiana 46804

Ph: (260) 242-2347

Email: goatguide@chillygoattubs.com www.chillygoattubs.com

Michael Phelps Chilly GOAT Cold Tubs by Master Spas are designed for exceptional cold water therapy. The innovative design features a contoured seat, built-in arm rests, and non-slip flooring. The powerful 2.1-horsepower chiller keeps the water consistently cold while a UV light and filter keep it clean. The Chilly GOAT has a temperature range of 40 degrees to 104 degrees. Easy installation, too. Fill, plug in, and go cold.

ChromaDex, Inc.

Booth #4044

10900 Wilshire Blvd., Ste 600 Los Angeles, California 90024

Ph: (949) 410-3984

Email: AlexM@chromadex.com www.niagenplus.com

Your NAD+ supply declines with age as well as in response to stressors on your body including alcohol consumption, intense exercise, and lack of sleep. While nicotinamide riboside can be found naturally in certain foods, you cannot get anywhere near the amount you need through a normal diet to effectively increase NAD+. That is why we created Tru Niagen®, the only patented, broadly studied, and safety-reviewed nicotinamide riboside in the world.

Clinicians Supplement Consultants

Booth #7046

180 Froehlich Farm Blvd.

Woodbury, New York 11797

Ph: (516) 222-2288

Email: dlc@cscprivatelabel.com www.cscprivatelabel.com

Clinicians Supplement Consultants allows practitioners to provide concierge service and sales of professional supplement brands and practitioners own private label supplements to their patients. CSC has an exclusive professional only brand, a concierge supplement fulfillment service, a private label development and management program. CSC allows practitioners focus on the patient while CSC handles all aspects of inventory, dispensing, fulfillment, and patient compliance . CSC handles the supplement business allowing practitioners to focus on their patients.

College Pharmacy

Booth #6038

3505 Austin Bluffs Pkwy Ste 101 Colorado Springs, Colorado 80918

Ph: (800) 888-9358 x137

Email: sky@collegepharmacy.com www.collegepharmacy.com

THE COLLEGE PHARMACY DIFFERENCE: QUALITY. INNOVATION. EXPERIENCE. SINCE 1974. For over 50 years, College Pharmacy has provided healthcare practitioners and patients with high-quality compounded preparations and outstanding customer service. Our experienced pharmacists collaborate with patients and healthcare practitioners to provide innovative solutions for health and wellness success. It is our compounding process, attention to detail, and quality of the compounding components that continues to make our formulations exceptional.

Compounder’s International Analytical Laboratory (CIAL)

Booth #1094

4760 Castleton Way Castle Rock, Colorado 80109

Ph: (303) 471-8015

Email: lab@compounderslab.com www.compounderslab.com

We are a full-service testing lab dedicated to assuring the quality of compounded medications. We specialize in testing peptide and hormone formulations in any dosage form. Our services include testing potency of the active ingredients, performing rapid sterility and endotoxin testing, establishing beyond use dating, and much, much more. We are FDA registered, centrally located in Colorado and have nearly 20 years experience working with these critical medications in our state-of-the-art laboratory. Please come by Booth 1094 and introduce yourself.

Congela Biocosmetics

Booth #5075

1728 Coral Way Ste 600 Miami, Florida 33145

Ph: (833) 436-8372

Email: info@juvexo.com www.juvexo.com

Congela Biocosmetics is a biocosmetic company that produces precision skincare that helps restore natural beauty at the cellular level. As a leader in biological cosmetics, Congela has combined biological research with expertise in the aesthetic industry to provide practitioners with optimal cosmetic solutions to common skin and hair concerns.

PHARMACY

Cool Blue VA

Booth #8104

2492 Walnut Ave. Ste 100

Tustin, California 92780

Ph: (714) 695-8000

Email: admin@coolblueva.com www.coolblueva.com

At Cool Blue VA, we pride ourselves on being perfectly matched to the needs of our clients. We offer a wide range of VA services, from handling everyday office tasks to transforming your practice altogether. And because we’re virtual, we can save you up to 70% compared to hiring in-house staff.

CRE8 Pharmacy

Booth

#3033

3700 NW 126th Avenue

Coral Springs, Florida 33065

Ph: (888) 224-5181

Email: david@cre8rx.com www.cre8pharmacy.com

CRE8 Pharmacy offers compounding services for personalized medicine and patient-specific prescriptions. We are a team, working at creating perfect formulations, dispensing orders reliably and resolving any issues promptly. Specializing in Peptides, Hormone Replacement Therapy, Sexual Wellness, Weight Loss & Energy, Cognitive & Mental Health formulas. Sterile & Non-Sterile compounds, Generic & Brand medications. Welcome to the future of compounding pharmacy.

CRMLab

Booth #7113

1001 NE 125th Street

Miami, Florida 33161

Ph: (954) 422-3801

Email: wilson@genorthix.com www.neuroregenesis.com

CRMLAB is a cutting-edge institution dedicated to advancing the field of regenerative medicine and providing innovative treatments for patients. Located in Miami, this renowned center brings together a multidisciplinary team of experts, including physicians, scientists, and researchers, who are at the forefront of regenerative medicine research and clinical practice.

Cyrex Laboratories

#3032

Ph: (800) 633-1400

Email: support@cryobuilt.com www.ww.cryobuilt.com

CryoBuilt, a Sacramento-based company, is the leading US manufacturer of electric whole-body cryotherapy systems. With over 400 chambers worldwide, they’re trusted by pro sports teams and wellness franchises. Offering cryo recovery for pain relief, muscle recovery, sleep, and more, CryoBuilt is expanding both domestically and internationally.

Ph: (602) 759-1245

Email: michelle.c@cyrexlabs.com www.joincyrex.com

Cyrex Laboratories® is a unique clinical immunology laboratory specializing in environmentally-induced autoimmunity. Cyrex delivers next generation assessments for antigenic intestinal and blood-brain barrier permeability – gateways to autoimmunity; environmental trigger screening including dietary antigens, pathogens and xenobiotics; and multitissue antibody testing for predictive biomarkers of autoimmune reactivity. Through continuous collaboration with leading experts in medical research and clinical practice, Cyrex develops innovative assays that assess the cross-connections between the body’s immune, gastrointestinal and neurological systems.

Daiwa By US Jaclean, Inc.

Booth #8043

1816 W. 135th St.

Ph: (800) 241-2221

Email: sales@usjaclean.com www.daiwamassage.com

U.S. Jaclean, Inc. is one of the leading health and wellness massage chairs distributors in the United States since 1982. Our mission: To improve the health and wellness of Americans through quality products that can be used from the comfort of home.

Darmerica

Booth #1048

4380 Oakes Rd. Ste 800

Davie, Florida 33314

Ph: (416) 925-8777

Email: SalesTeam@Darmerica.com www.darmerica.com

Darmerica is a Florida based, FDA Inspected, cGMP compliant, wholesale distributor of APIs, Peptides & Nutraceuticals for compounding pharmacies. We are licensed to ship nationwide and work with the largest compounders in the United States and internationally.

DaVinci Laboratories

Booth #6117

929 Harvest Lane

Williston, Vermont 05495

Ph: (802) 881-4509

Email: tjohnson@foodsciencecorp.com www.davincilabs.com

Since 1973, DaVinci® Laboratories has been a leader in nutritional research, product development and innovation. Our dedication to higher integrity, and insistence on superior quality are reflections of our core values. Today, DaVinci® continues to set new standards for quality and product innovation to keep you as healthy and informed as possible. Our team of experts is always willing to assist you in matters relating to nutrition.

Delavie Sciences

Booth

#9105

365 Plantation St. Ste 175

Worcester, Massachusetts 01605

Ph: (508) 459-8803

Email: info@delaviesciences.com www.delaviesciences.com

Delavie Sciences mission is to enhance self-confidence by focusing on the first thing the world sees: your skin. We’re revolutionizing skincare with innovative, scientifically-backed solutions. Through years of research and collaboration with industry leaders, we’ve created cutting-edge products, featuring patented ingredients like Bacillus Lysate—a revolutionary ingredient derived from a microorganism exposed to the extreme conditions of space. Exclusive to our Aeonia collection, this breakthrough ingredient offers unparalleled results, disrupting the skincare market.

Designer Drugs Pharmacy

Jarnigan Rd.

Ph: (423) 954-2585

Email: form-submission@squarespace.info www.designerdrugs.us/

For more than 20 years, Designer Drugs has been working with patients and physicians to provide custom solutions for their pharmaceutical needs. Our technicians are certified to compound sterile and non-sterile medications. Our pharmacy proudly compounds ophthalmics, injections, dermatologic preparations, hormone replacement options, and many more products. These preparations are designed specifically to meet individual needs with the highest level of safety and accuracy. Designer Drugs is licensed to ship prescriptions to all fifty states.

Designs for Health

DEXA+

Ph: (860) 752-7474

Email: sciencefirst@designsforhealth.com www.designsforhealth.com

Our Mission: Designing a Well World We are driven by a higher purpose. We are activists for health - rooted in and united by science. Transforming boundaries, breaking barriers, setting new standards, disrupting the status quo. We believe in science-based nutrition and natural medicine, developing health products without compromise, and advancing the way education and technology support wellness for all. We design a new paradigm. We design a well world.

Ph: (586) 532-1150

Email: torlando@dexaplus.com www.dexaplus.com

DEXA+ is a provider DEXA Scanners and an educator of the benefits of DEXA and the 3 Critical Health Markers (Bone Health, Body Composition and Visceral Fat, the number predictor of heart disease and Type 2 Diabetes.) Our Scanners and Programs provide State of the Art equipment and leading technology for clinics. If you would like to include DEXA in your clinic DEXA+ is the leader in the industry. Contact us to learn more.

Diagnoptics Technologies b.v

Booth #9035

Aarhusweg 4-9

Groningen, Groningen 9723 JJ

Ph: 31 50 589 0612

Email: info@diagnoptics.com www.diagnoptics.com

Diagnoptics develops non-invasive devices to measure Advanced Glycation End products (AGEs) using Skin Autofluorescence (SAF). AGEs are known to contribute to premature aging and the development of many chronic diseases. Developed by medical doctors in the Netherlands, the technology has been proven in over 300 scientific publications across the globe. These show that the AGE level in human tissue is a valuable bio marker in the prevention and management of life style related illnesses and longevity.

Diagnostic Solutions Lab

Booth #1021

31 Lupi Court Ste 250 Palm Coast, Florida 32137

Ph: (877) 485-5336 x1002

Email: cs@diagnosticsolutionslab.com www.diagnosticsolutionslab.com

Diagnostic Solutions Laboratory bridges the gap between healthcare providers and the clinical laboratory by offering cutting-edge laboratory tests such as GI-MAP, OMX (Organic Metabolomics), CytoDX, and GenomicInsight. Designed to identify underlying root causes of symptoms and disease, our test results give practitioners the tools needed to formulate personalized treatment protocols for optimized patient outcomes. Our commitment to education and service ensures both practitioners and their patients will benefit from the latest research.

Doctor Multimedia

Booth

#3042

8070 La Jolla Shores Dr. #528 La Jolla, California 92037

Ph: (800) 679-3309

Email: info@doctormultimedia.com www.doctormultimedia.com

We’re a team of energetic, young professionals. We’re successful for one simple reason: no one can outwork us. We’re open 24 hours a day, 7 days a week, 365 days a year. We do it out of passion, and because that’s when our clients need help. We have graphic designers, WordPress developers, social media masters, content creators, SEO wizards, IT problem solvers, and marketing gurus, ready to help your medical practice thrive.

Doctor’s Data, Inc.

Booth

3755 Illinois Ave. St. Charles, Illinois 60174

Ph: (630) 377-8139

Email: info@DoctorsData.com www.doctorsdata.com

Doctor’s Data, Inc. has provided innovative specialty testing to healthcare practitioners around the world from our advanced, CLIA-licensed clinical laboratory since 1972. A specialist and pioneer in essential and toxic elemental testing, the laboratory provides a wide array of functional testing to aid in decision making and better patient outcomes. Choose DDI to help you assess and treat heavy metal burden, nutritional deficiencies, gastrointestinal function, hormone status, cardiovascular risk, liver and metabolic abnormalities, and more.

Double Helix Water

#2067

Ph: (800) 928-6883

Email: info@doublehelixwater.com www.doublehelixwater.com

Studies indicate that Double Helix Water® has an anti-inflammatory effect as well as a positive impact on your immune system and cellular function. Described as having a unique structure where water molecules form stable clusters that, when merged in large numbers, create formations reminiscent of the DNA’s double helix. This structure is said to be different from regular water due to the stable nature of these clusters, which do not change with temperature, suggesting a new phase of water.

Dp Derm / Dermapenworld

Booth

#1042

11900 Biscayne Blvd, Ste 292 North Miami, Florida 33181 US

Ph: (305) 552-0550

Email: info@dpderm.com www.dpderm.com

DpDerm is the US Distributor for Dermapenworld. The FDA Cleared DP4 (Dermapen4) is the No.1 Microneedling device in the world. Along with DpDermaceuticals protocol skincare products, which are Non-Negotiables during skin needling, it has provided exceptional outcomes when combined with our effective homecare regimes. Our latest breakthrough - Exosomes - are taking the anti-aging world by storm. By combining In-clinic treatment serums with a take home Exosome booster, you can provide your clients with a complete anti-aging solution.

Revolutionary Skincare Powered by Gene Science

Developed by a Geneticist and Regenerative Doctor

Klotho Skin is the first skincare line designed to harness the power of the age-suppressing Klotho protein utilizing the cell-conditioned medium from genetically modified stem cells.

CONFERENCE SPECIAL:

25% on Face Serum, Eye Serum and Night Cream

Preorder our new Microneedling Klotho Complexe now. $75 (instead of $95) Does not need to be refrigerated.

BE SUPER BE SUPER HUMAN. HUMAN.

ELIMINATE FATIGUE

PEAK CLARITY & FOCUS

MAXIMIZE IMMUNE SYSTEM & BRAIN FUNCTION

LENGTHEN TELOMERES

REVERSE WRINKLES

DR. BOSS ®

The King of Medical Massage Chair

Dr. Fuji / ACIGI

Booth #3067

4399 Ingot Street

Fremont, California 94538

Ph: (510) 651-9088

Email: marketing@drfuji.com www.drfuji.com

Dr. Boss and Dr. Fuji Health & Wellness massage equipment, is the fruit of further evolution of intelligent pneumatic and mechanical milt-technology designed to partner with medical and health professionals in their clinical stress managements.

Dr. PRP USA

Booth #9023

3727 Greenbriar Dr. Ste 103 Stafford, Texas 77477

Ph: (844) 377-7787

Email: hello@drprpusa.com www.drprpusa.com

At Dr. PRP USA, we’re not just part of the regenerative medicine industry—we’re reshaping it. As a privately-held pioneer in the field, we’re committed to driving innovation, embracing cutting-edge technology, and reshaping patient outcomes. Our advanced, FDA 510K Cleared Platelet Rich Plasma (PRP) preparation kits are helping revolutionize regenerative therapy, making treatments more efficient and accessible. We’re on a mission to turbocharge the healing process, using the body’s own power to overcome today’s medical challenges.

DrWell

Ph: (401) 649-0086

Email: chad@buildmybod.com www.buildmybod.com

DrWell provides an integrated solution to manage your health and wellness programs by upgrading patients access to medications, automating your billing, and simplifying Prescription ordering so that you can improve patient outcomes.

DUTCH Test (Precision Analytical)

DrTalks

Booth

#1039

7040 Avenida Encinas, Ste 104-284 Carlsbad, California 92011

Ph: (619) 436-7750

Email: bret@drtalks.com www.drtalks.com

DrTalks was established to provide real people with access to leading experts in health, wellness, and medical fields. Through our exclusive partnership, we offer ongoing, curated content tailored to your interests. Whether you’re looking to unlock the secrets of genetics, enhance your health through nutrition and exercise, learn about the latest cancer breakthroughs, or manage chronic conditions and pain, we bring you the latest insights directly from the doctors themselves.

Ph: (503) 687-2050

Email: sales@dutchtest.com www.dutchtest.com

Precision Analytical created the DUTCH Test (dried urine test for comprehensive hormones) to help providers solve complex patient cases and profoundly change lives. DUTCH is a group of accurate and research-validated tests that provide a complete evaluation of a patient’s sex and adrenal hormones, including metabolites. The DUTCH Test uses convenient at-home collection with unparalleled clinical support and education, to give providers the tools they need to solve their patients’ most complex hormone-related issues.

Earth Compounding Pharmacy

Lincoln Ave. Pasadena, California 91103

Ph: (310) 550-1822

Email: rx@greatearthpharmacy.com www.greatearthpharmacy.com

At Earth Compounding Pharmacy, we craft custom medications tailored to the unique needs of patients seeking to optimize health and longevity. Specializing in bio-identical hormone replacement therapy, weight management, hair loss formulations, detoxification, and other patient-specific compounds, we ensure innovative, evidence-based care. Our personalized approach makes us an ideal partner for A4M practitioners focused on delivering high-quality, custom anti-aging therapies that enhance patient outcomes and support healthy aging. We offer FREE shipping. Stop by our booth to get our coupons.

Eazewave

Booth #9097

107 E. Rialto Ave.

San Bernadino, California 92408

Ph: (619) 726-7873

Email: john@sleepwavetechnologies.com www.eazewave.com

Sleep Life Inc is a company that manufactures a Sleep Enhancement System and is sold under the Eazewave.com brand and web site in the US and under Sleepwave.com outside of the US. The system comprises of a Patented and Clinically Tested Technology Designed to Stimulate, Elevate, Tune and Stabilize the Body’s Energy Points to Promote Better, Longer, and Deeper Sleep.

Echo Water

Booth #8108

875 East 1950 North Spanish Fork, Utah 84660

Ph: (855) 737-1114

Email: support@echowater.com www.echowater.com

At Echo Water, we give you the means to make hydrogen water safely wherever you are. Hydrogen water is regular water (H2O) that we infuse with extra hydrogen molecules (H2). But why add hydrogen? Research shows that hydrogen, being the smallest and lightest molecule, can easily penetrate into cells, offering unique health benefits that regular water can’t. It can help reduce oxidative stress (a big factor in aging and disease), boost energy, and even enhance athletic performance.

Empower Pharmacy

Booth #4055

7601 N. Sam Houston Pkwy. W. Houston, Texas 77064

Ph: (877) 562-8577

Email: marketingcomms@empowerpharmacy. com

www.empowerpharmacy.com

Empower Pharmacy is at the cutting edge of healthcare innovation, committed to ensuring that quality, affordable medications are accessible to everyone. Our talented team combines engineering precision with pharmaceutical expertise, positioning us as the largest 503A compounding pharmacy and FDA-registered 503B outsourcing facility in the nation, dedicated to personalized medicine. We strive to transform lives through innovative medications, working collaboratively towards a healthier, happier future for all.

EnergyBits Inc.

Booth #7109

9 Hawthorne Place Boston, Massachusetts 02114 US

Ph: (877) 594-7030

Email: customercare@energybits.com www.energybits.com

ENERGYbits® sells physician-grade spirulina and chlorella algae tablets called “bits” because they are “bits of food”. Our tablets contain 40 vitamins/minerals including the world’s highest concentration of SOD (superoxide dismutase), chlorophyll and glutathione, all scientifically proven to reduce inflammation, improve longevity, prevent chronic disease and restore mitochondria. Simply swallow or chew a handful of bits daily to effortlessly restore and protect your health. Visit ENERGYbits booth for FREE SAMPLES and open your practitioner wholesale account.

electroCore, Inc.

Booth #7119

200 Forge Way Ste 205 Rockaway, New Jersey 07866-2055

Ph: (631) 317-7970

Email: CustomerService@electroCore.com www.electrocore.com

Founded in 2005, electroCore is dedicated to advancing health through its innovative neuromodulation technology. Using patented vagus nerve stimulation (VNS) technology, electroCore develops medical devices and consumer products that promote wellness. Their flagship product, gammaCore™, is an FDA-cleared non-invasive vagus nerve stimulator (nVNS) designed to treat headache pain associated with migraine and cluster headaches. Additionally, electroCore offers Truvaga™, a wellness device aimed at reducing stress and balancing the nervous system.

Eng3 Corporation

Booth #1028

2234 Eastlake Ave E Ste A Seattle, Washington 98102 US

Ph: (206) 525-0227

Email: customer.care@eng3.com www.eng3corp.com

Eng3 approaches the problem of cell damage by focusing on protein structure and folding. Functional proteins are “folded”; however, oxidative stress causes proteins to “unfold”. Since proteins are involved in all cellular processes, repairing them is critical. Eng3’s NanoVi® technology has been proven to reinstate protein activities - and is used to: · BOOST PERFORMANCE - for stronger physical and mental fitness · PRESERVE WELLNESS - for vitality and quality of life · JUMPSTART REGENERATION - to address age-related disorders

Entity Health Limited

Booth #7115

3500 South DuPont Hwy

Dover, Delaware 19901

Ph: (510) 542-0011

Email: jose.flores@entity-health.com www.entity-health.com

Entity is a longevity-focused supplements brand dedicated to promoting health span through innovative products. Utilizing a patented and proprietary sublingual technology, WaferiX®, we deliver actives like NAD directly into the body. Our flagship products include SL-NAD+ (NAD) to boost cellular energy and support healthy aging, and LumeniX (Glutathione) for detoxification and immune support. Manufactured in Melbourne, Australia, under TGA cGMP-certified conditions, Entity ensures the highest quality and safety standards.

Epionce

Booth #8032

10211 W. Emerald Street Boise, Idaho 83704

Ph: (866) 374-6623

Email: info@epionce.com www.epionce.com

Epionce is a dermatologist-developed, medical-grade skincare brand that has been obsessed with a healthy skin barrier for over 20 years. Sold by medical skincare professionals, our elegant formulations are made with barrier-boosting cholesterol and ceramides, and antioxidant-rich botanical blends that show measurable benefit in the skin. Formulas have undergone over 15 rigorous independent clinical trials to prove safety and efficacy. Our philosophy is simple: put your skin barrier first, and beautiful skin will follow.

EquiLife Health Solutions

Booth #1104

55 West Street Walpole, Massachusetts 02081

Ph: (888) 300-5601

Email: healthsolutions@equi.life www.equi.life/healthsolutions

EquiLife Health Solutions is your partner in delivering wellness solutions that work. We offer science-backed supplements, Functional Medicine lab testing, and personalized health coaching to help people get well and stay well for life.

Ergo-Flex

Technologies

Booth #8047

136 Poplar Circle Ste 403

Ph: (936) 588-5510

Email: Sales@ergoflextechnologies.com www.ergoflextechnologies.com

Ergo-Flex Technologies, LLC. is the developer, manufacturer, and distributor of innovative equipment to help patients with pain relief and offer healthcare practitioners the opportunity to set themselves apart, taking their practices to the next level. Products include Back On Trac, Knee On Trac. Cervi-Trac and Total Brain & Body O2. ERPS

Group, LLC

76 W Brighton Avenue Ste 206 Brooklyn, New York 11224

Ph: (347) 462-2778

Email: social@erpsgroup.com www.erpsgroup.com

At ERPS GROUP, we empower medical & wellness professionals, as well as business owners, to achieve financial freedom & long-term financial longevity. Our expert coaching in strategic tax planning, business growth, and passive income creation provides personalized strategies to optimize your financial health, minimize tax liabilities, and maximize wealth. We help you navigate the complexities of the tax system & build income streams that endure. Partner with us to secure your financial future & achieve lasting success!

Eterna Health

3095 Glen Erin Dr. Mississauga, Ontario L5L1J3 CA

Ph: (416) 840-3500

Email: careteam@eterna.health www.eterna.health/

We are a group of world-renowned specialists with breakthrough treatments to increase the healthspan and lifespan of humans.

Eternity Medicine

Booth #9092

313 Pilot Road Ste B

Las Vegas, Nevada 89119

Ph: (725) 204-8972

Email: INFO@ETERNITYMEDICINE.COM www.eternitymedicine.com

Reinventing Medicine to democratize Health Care.

European Wellness Biomedical Group

Booth #2099

Klosterstrasse 205

Edenkoben, Rheinland-Pfalz 67480

Ph: (6)(017) 672-8888

Email: info@european-wellness.com www.european-wellness.eu/

European Wellness Biomedical Group (EW Group) is an international multi-award-winning European group renowned for its pioneering developments in precursor stem cell therapeutics, immunomodulation, biological and synthetic peptides, nutraceuticals, cosmeceuticals and biological regenerative medicine. Headed by esteemed scientist and stem cell research pioneer Prof. Dato’ Sri Dr. Mike Chan, the Group owns over 20 international patents and has contributed over 50+ books and over 100+ publications in science and medicine in the US and UK.

EVEXIAS Health Solutions

Booth #5019

920 S. Kimball Ave. Southlake, Texas 76092

Ph: (833) 839-4735

Email: events@evexias.com www.evexias.com

EVEXIAS Health Solutions is revolutionizing the practice of medicine toward a preventive care model that positively impacts patient lives while also allowing practitioners to grow their practice. The EVEXIAS team has helped thousands of practitioners across the nation enhance patient care and expand their bottom line through advanced medical education and training from industry-leading medical practitioners, researchers, and scientists, as well as providing access to leadingedge therapies and technologies that support the prevention of disease and improve quality of life.

2457 Aviation Ave. Ste 102 North Charleston, South Carolina 29406 US

Ph: (888) 983-8658

Email: Info@evolt360.com www.evolt360.com

Evolt is a pioneering company specializing in advanced body composition analysis solutions, catering not only to individuals but also offering extensive benefits to businesses. Our state-of-the-art technology empowers fitness centers, wellness facilities, and healthcare providers to deliver personalized services, enhance client engagement, and drive business growth. Visit EVOLT360.COM for more information.

ExoMedTech

Email: info@exomedtech.com www.exomedtech.com

At ExoMedTech, we are pioneers in developing and manufacturing pharmaceutical-grade MSC (Mesenchymal Stem Cell) Exosomes, pushing the boundaries of what’s possible in regenerative medicine and therapeutic innovation.

ExtendingMe

Ph: (817) 343-6099

Email: info@extendingme.com www.extendingme.com

ExtendingMe is a comprehensive and personalized genetics laboratory specializing in longevity support. Our core offering is “lifetime” genetic testing service for a one time upfront investment. Patients will receive provider consultations, quarterly genetic reports to optimize their overall health and longevity journey. Additionally, patients will have educational support to assist them in interpreting their results. Their reports will provide tailored solutions for supplements, food, exercise and lifestyle improvements.

Evolt

Booth #3061

Here, You’re Part of the Family.

As a family-owned company, we pride ourselves on making functional nutrition feel more like family. In a market where healthcare practitioners are often overlooked, we strive to be a trusted, transparent source of supplements and support for you and your practice, giving both you and your patients an improved quality of life. Our practitioner-exclusive approach is designed to meet the unique needs of your practice and patients, ensuring that you have access to high-quality, reliable products tailored for clinical use to provide optimal patient outcomes.

When you partner with NutriDyn, we can enhance your patients’ well-being while driving your practice’s growth and success.

EZRA EHR

Booth #8114

10668 N 5720 W

Highland Heights, Utah 84003

Ph: (801) 636-8775

Email: daniel@ezraehr.com www.ezraehr.com

AI Health Technologies provides top-level technology for patient-centered providers. Our pilot product, EZRA, is an EHR with artificial intelligence integrated into the system to offload administrative tasks, manage patient cases, increase scheduling, and drive more revenue to your practice. We want doctors to spend their time being doctors rather than administrators, all while increasing practice revenue and profitability. Discover how EZRA can transform your practice today.

Flore Clinical

Booth #5093

5151 Shoreham Place Ste 175

Ph: (858) 900-9698

Email: floreclinical@sungenomics.com www.floreclinical.com

Your microbiome wellness experts - Floré Clinical. The one-stop solution for root-cause Microbiome Analysis & 100% Custom Synbiotics. Whole Genome Microbiome Testing coupled with Floré 100% customized probiotics and prebiotics are proven functional tools enabling you to take a root-cause medicine approach that can be the game changer in patient care.

Fagron Genomics US

Booth #

7099

807 Las Cimas Pkwy Ste 145 Austin, Texas 78746

Ph: (512) 258-5564

Email: info@fagrongenomicsus.com www.fagrongenomicsus.com

Fagron Genomics US, based in Austin, TX, is a leading biotechnology company and laboratory providing a cutting-edge Nutrigenomic and Pharmacogenomic testing platform exclusively for medical professionals. Our tailored software allows practitioners to validate a patient’s specific nutritional needs, laboratory recommendations, lifestyle recommendations and health precautions based on individual DNA findings. Through a simple cheek swab, our turnkey solution offers affordable testing, presenting comprehensive SNP analysis and swift interpretation for targeted recommendations, promoting personalized health and recovery.

Fatty15

Booth #4064

2907 Shelter Island Dr. Ste 105-411

San Diego, California 92106

Ph: (619) 374-9716

Email: info@fatty15.com www.fatty15.com

Fatty15 is the world’s first, and only science-backed, patented, award-winning C15:0 supplement that supports your long-term health & wellness. As the first essential fatty acid to be discovered in over 90 years, voluminous science has shown that the pure C15:0 ingredient in fatty15 is critical to supporting metabolic, liver, heart and immune health via 36+ cellular benefits surpassing those of leading healthspan and longevity-enhancing molecules. With 3x more cellular benefits than omega-3, fatty15 is your essential, essential fatty acid.

Formula30A

Booth #2039

1992 Lewis Turner Blvd. Fort Walton Beach, Florida 32547 US

Ph: (850) 801-3377

Email: info@formula30a.com www.formula30a.com

Formula30A crafts premium, all-natural hemp products for medical providers, revolutionizing patient health, wellness, and recovery. As pioneers in full-spectrum cannabinoid oils and the first in the US to conduct an IRB study with CBG, we ensure our products have the purest ingredients and safest methods. Trusted by top medical professionals, Formula30A blends nature’s power with medical expertise for unmatched health and well-being.

Forum Health Booth #7074

601 S. Saginaw St. 5th floor Flint, Michigan 48502

Ph: (855) 796-9645

Email: info@forumhealth.com www.forumhealth.com

Forum Health is a growing network of healthcare providers & practices who serve patients around the world. Our providers have decades of experience practicing functional and integrative medicinedrawn from areas in clinical nutrition, anti-aging, environmental science, chronic disease, lifestyle medicine and more. Through practice acquisition and employing talented healthcare providers, we connect the best like-minded practitioners with business experts and a network of collaborative peers. Become part of our network today!

Fotona

Booth #1016

4343 W Royal Lane Ste 116

Irving, Texas 75063

Ph: (972) 804-2391

Email: info@fotona.org www.fotona.com

Globally recognized for exceptional product performance and versatility, Fotona’s award-winning aesthetic lasers include the revenue-boosting SP Dynamis, TimeWalker and StarWalker. With over 50 years of laser expertise and industry leadership, Fotona has sold over 30,000 lasers worldwide with distribution in over 60 countries. Fotona’s reputation for excellence is earned from its dedication to R&D, unparalleled quality, reliability, ease-of-use and durability.

Fountain Medical Supplies, Inc.

Booth #3126

1223 S 1840 W Orem, Utah 84058

Ph: (801) 980-9022

Email: info@fountainmedicalsupplies.com www.fountainmedicalsupplies.com

Fountain Medical Supplies is a a manufacturer and a distributor of medical equipment, disposable medical supplies, and pharmaceuticals.

FUJIIRYOKI MASSAGE CHAIRS

Booth #1033

371 Van Ness Way Ste 220

TORRANCE, California 90501

Ph: Dr. Timothy Sharpe

Email: tim.sharpe@fujiiryoki.com www.fujiiryoki.com

Fujiiryoki Massage Chair is the oldest massage manufacturer in the world and the inventor of the world’s first massage chair in 1954. We are the largest brand in Japan and have extensive global distribution through our Fujiiryoki - Japan, DCore - Japan, Synca Wellness and Inner Balance Wellness brands. The Fujiiryoki massage mechanism is unparalleled in its design, engineering and manufacturing, and its incredible movement and rhythm capabilities.

Fullscript

Booth #2027

1750 Elm St. #1200 Manchester, New Hampshire 03104

Ph: (866) 807-3828

Email: support@fullscript.com www.fullscript.com

Fullscript® is the leading online platform for practitioners to manage and dispense healthcare’s best supplements — in-office or to patients’ doors. Practitioners become a safe, convenient source for trusted wellness products with the choice to offer savings, earn revenue, or both. Time-saving features, automated adherence tools, and more help physicians minimize admin, grow their practices, and keep patients engaged.

Functional Mind™

Booth #9042

21500 Biscayne Blvd. Ste 600

Ph: (754) 260-6507

Email: info@functionalmind.ai www.functionalmind.ai

Functional Mind™ is a groundbreaking AI chatbot offering ‘real-time’ clinical decision support and hallucination-free research for functional and integrative medicine practitioners. It delivers personalized recommendations using extensive medical data sources and expert knowledge. By streamlining and enhancing decision-making, Functional Mind™ empowers practitioners with upto-date insights, optimizing efficiency and improving patient outcomes. This essential, customizable, resource enhances care strategies for root causefocused medicine, enabling practitioners to provide accurate, reliable, and personalized patient care.

GAINSWave®

Booth #6026

2980 NE 207th Street Ste 503

Ph: (855) 383-5779

Email: team@gainswave.com www.gainswave.com

GAINSWave® is the leading brand of extracorporeal shockwave therapy (ESWT) for sexual wellness, trusted by highly-trained medical providers. Designed for both men and women, this all-natural, clinically proven treatment enhances sexual function, performance, and overall health. By increasing blood flow, forming new blood vessels, and breaking down micro-plaque, GAINSWave® addresses the root causes of dysfunction. This non-invasive, painless procedure offers a drug-free solution for improved sexual health, providing healthcare providers a powerful tool to boost patient outcomes.

GastroDefense

Booth #3105

30 N. Alamos Dr. Cottonwood, Arizona 86326

Ph: (928) 399-0637

Email: info@gastrodefense.com www.gastrodefense.com

GastroDefense is a worldwide leader in the bovine colostrum supplement industry for healthcare professionals. For three decades, we’ve dedicated ourselves to developing natural products that provide efficacious solutions for optimal gut health, vitality, aesthetics, and healthy aging. Company founder Douglas Wyatt is a leading authority on colostrum and is credited with establishing the gold standard in processing raw bovine colostrum into supplements. Mr. Wyatt is also an early developer of liposomal delivery for enhanced bioavailability of colostrum supplements.

Genova Diagnostics

Booth #6027

63 Zillicoa St. Asheville, North Carolina 28801

Ph: (828) 210-7362

Email: info@gdx.net www.gdx.net/

Genova Diagnostics is a leading force in the world of healthcare, transforming the way chronic diseases are diagnosed, treated, and prevented. With a focus on empowering individuals to achieve optimal well-being, our advanced lab testing methodologies target crucial areas like gut health, nutritional status, immune function, and hormonal health. At Genova, we’re shaping a brighter and healthier future, where innovative approaches to personalized healthcare empower individuals to thrive. Learn more at www.gdx.net.

German – French Society for Thymus Therapy

Booth

#1044

Place du Marche Grimaud, 83310

Ph:

Email: info@thymus-therapie.org www.thymus-therapy.org

Thymus Therapy, as part of Xenogene Cell Therapy, is a powerful therapy which has been used for many decades in beauty and medical treatments.

Ginger Allen

980 N. Federal Hwy Ste 110

Boca Raton, Florida 33432

Ph: (866) 623-1133

Email: info@ymlteam.com www.yourmedicalliaison.com

Your Medical Liaison – Full Service Marketing for Functional & Integrative Medical Practices. Since 2012, we’ve been the trusted partner for MD/DOs, offering full service solutions designed to attract ideal patients, grow your practice, and maximize ROI—all without adding to your workload. Let us take care of the complexities of medical marketing, so you can reclaim valuable time for yourself and your loved ones. SIGN UP FOR YOUR FREE MEDICAL MARKETING AUDIT TODAY at www.YMLTeam.com

Global Life Rejuvenation

Ph: (973) 627-1750

Email: demetriaglaab@denvillemedical.com www.globalliferejuvenation.com

Global Life Rejuvenation A Leader in Anti-Aging Medicine and Hormone Replacement Therapy for Men and Women. Global Life Rejuvenation has Network Providers nationwide. Global Life educates and connects patients with our highly trained network physicians specializing in Anti -Aging Medicine. Glocal Lab, LLC.

Ph: (949) 501-8011

Email: irad@glocallab.us www.glocalcure.com

GLOCAL LAB, where healthcare innovation meets real-world solutions. Founded by a passionate team of pharmaceutical scientists and healthcare professionals, we are committed to addressing pressing healthcare challenges and delivering tangible value. With deep market insight and a robust network of key opinion leaders and practitioners, we bring 100% natural nutraceutical supplements that treat specific skin concerns holistically and systemically, offering a unique, science-backed approach to skin health.We have 5 Nutraceutical capsules and one silicon-based cream.

Booth #1022

GlycanAge Ltd.

Booth #8080

The Catalyst 3 Science Square, Newcastle Helix Newcastle Upon Tyne Newcastle, England NE4 5TG

Ph: (44)(752) 571-7807

Email: zorrie@glycanage.com www.glycanage.com

GlycanAge is a pioneering biotech company offering the most actionable aging biomarker for personalized medicine. By assessing glycome changes that affect immune function, inflammation, and age-related conditions, GlycanAge provides insights backed by 300+ studies. It responds to lifestyle and pharmaceutical interventions, empowering you to track and optimize your health. Measure your true biological age, predict future well-being, and take control of your aging journey with GlycanAge’s personalized health solutions.

Grand Ave Pharmacy

Booth

#2085

1615 Grand Ave Pkwy Ste 104 Pflugerville, Texas 78660

Ph: (512) 987-1919

Email: GrandAvePharmacySales@gmail.com www.grandavenuerx.com

Founded in 2012, Grand Ave Pharmacy is a leading provider of high-quality compounded medications, dedicated to enhancing patient care through tailored pharmaceutical solutions. With strong emphasis on both sterile and non-sterile compounding, we specialize in innovative treatments, including peptides, weight loss, hormone replacement therapy (HRT), and intravenous (IV) medications. Based in Austin,Texas, we proudly extend our services to customers in 25+ states nationwide. We are committed to supporting healthcare providers and patients in their pursuit of optimal health and wellness.

SCIENCE HAIR

Hair Science

Booth #3047

608 Point Vista Drive ALEDO, Texas 76008

Ph: (866) 558-1744

Email: info@hairscience.com www.hairccience.com

Hair Science is a research and development company dedicated to advancing products that improve hair and scalp health. Come visit our booth to learn about our prescription-based hair loss treatments, Formulas 82M, 82F, and 82D and our over-thecounter hair loss shampoo, Formula 82S.

675 Alpha Dr. Ste E Highland Heights, Ohio 44143

Ph: (216) 543-8169

Email: Info@myhairsmart.com www.myhairsmart.com

HairSmart has combined Modern Western Technology of Low-Level Light Therapy + Ancient Eastern Science of Ayurveda + High Performing Nutritional Superfoods to create COMPLETE hair growth solutions for distinct needs.

Hallandale Pharmacy

SW 36th

Ph: (954) 455-3822

Email: newaccounts@hallandalerx.com www.hallandalerx.com

Hallandale Pharmacy’s is a 503a designated and PCAB accredited compounding pharmacy, that is committed to provide quality and affordable custom prescription formulations nationwide. The cGMP guidelines that Hallandale Pharmacy has adopted is led by our Quality Assurance team and supporting staff. While quality is the foundation of our practice, our service to our patients and providers drives our mission. We regard our relationships with our trusted practitioners as a partnership.

Hawaiian Moon

Booth

#

3095 321 S. Missouri Ave

Ph: (888) 256-3276

Email: customerservice@hmaloe.com www.aloecream.biz

Say Goodbye to Dry Skin with Hawaiian Moon Organic Aloe Cream! It is free of dyes, fragrance, parabens, sulfates, mineral oil_, and any other harsh chemicals, including petroleum. Our cream penetrates the skin up to 7 layers deep, and absorbs into the skin instantly.

Heads Up

Booth #8092

4400 N Scottsdale Rd. Ste 9445 Scottsdale, Arizona 85251

Ph: (602) 671-3074

Email: support@headsuphealth.com www.headsuphealth.com

Improve outcomes, save clinical time, and maximize client engagement with Heads Up—the connected health data intelligence platform designed for concierge longevity programs. By consolidating data from wearables, devices, labs, and diagnostics into a single, user-friendly dashboard, Heads Up streamlines personalized, proactive management. Practitioners gain real-time insights into patient progress while reducing manual data tracking, saving valuable time. This platform enhances both precision healthcare and long-term wellness optimization, ensuring more efficient, effective patient care delivery.

Health & Beauty Connection

Booth #2114

2642 Rosselle St. #9 Jacksonville, Florida 32204

Ph: (407) 331-6292

Email: info@hnbc.us www.hnbconnection.com

We sell whole body vibration machines for personal and commercial usage.

Health Experts Alliance

Booth #3115

12460 Crabapple Rd. Ste 340 Alpharetta, Georgia 30004

Ph: (810) 449-0854

Email: support@healthexpertsalliance.com

www.healthexpertsalliance.com

We empower the doctors of the future with cutting-edge longevity training, systems, and business education so they can create more impact, more income, and more freedom.

Healthgevity

Booth

#8023

21a Allen Ave

Allenhurst, New Jersey 07711

Ph: (833) 940-4898

Email: support@healthgev.com www.healthgev.com

Healthgevity is at the forefront of pioneering science, dedicated to unlocking the potential of orally bioavailable peptides, proteins, and other natural bioactives. Our products are meticulously designed to enhance longevity, optimize healthspan, and elevate overall quality of life. Our mission is driven by a deep commitment to innovation and collaboration. We partner with leading doctors and scientific researchers to translate cutting-edge discoveries into advanced therapeutic nutraceuticals. With a focus on delivering the most effective, scientifically validated solutions.

Hilltek

Booth #8128

222 North Pacific Coast Highway Ste # 2000 El Segundo, California 90245

Ph: (949) 620-1408

Email: support@hitopus.com www.hitopus.com

HiToP® is a new, holistic energy-based therapy that provides a unique solution for longevity and wellness. HiToP® heals and enhances body function by vibrating and energizing cell and tissue particles via two-dimensional oscillations sent deep into the body. This empowers the body’s natural capabilities to repair and rejuvenate cells. HiToP® benefits extend across chemical detoxification, digestive health, pain management, vitalization, and more. HiToP® is represented by Hilltek LLC.

Holistic Care

Booth #1098

4558 Agua Caliente Blvd. Ste CC1B Tijuana, Baja California 22420

Ph: (619) 365-9003

Email: info@holisticcare.com www.holisticcare.com

With over 25 years of experience, Holistic Care provides cutting-edge treatments through three areas: American Biodental Center, Holistic Care, and Bergman Family Chiropractic. Trained by Dr. Hal Huggins, we excel in biological dentistry. Our medical clinic specializes in Mesenchymal Stem Cell treatments produced in our in-house lab. We take an integrative approach, addressing root causes and offering both conventional and alternative therapies.

Hormone Therapy Centers of America

Booth #8039

5 Cowboys Way Ste 300

Frisco, Texas 75034

Ph: (469) 214-0816

Email: rhettrichardson@ht-ca.com www.ht-ca.com

HTCA partners with practices to provide a full turnkey solution to implementing Bioidentical Hormone Replacement Therapy into your Practice, Clinic, or Med Spa. Our program consists of five key components: training, dosing, materials, marketing, and support.

Host Defense Mushrooms

Booth #9038

PO Box 7634

Olympia, Washington 98507

Ph: (877) 504-6926

Email: info@fungi.com www.hostdefense.com

Host Defense® Mushrooms™ was founded by renowned mycologist Paul Stamets with the goal of building a bridge between people and fungi. Offering multiple delivery formats is one way they work to offer convenience and ease-of-use to any supplement regime. Host Defense mycelium-based products are available in capsules, extracts, sprays, powders, drink mixes, and more! Additionally, their MycoBotanicals® line is expertly formulated using organically-grown mushroom mycelium and herbs, fusing contemporary science with the innate intelligence of nature.

Hue Light USA

Booth #1056

146 Rock Hill Dr PO Box 960

Rock Hill, New York 12775

Ph: (845) 796-9951

Email: info@huelightusa.com

www.huelightusa.com

Hue Light USA is a medical technology company, distributing advanced wellness devices to the U.S. market. Our flagship offering is BAHI Therapy, a comprehensive care program that utilizes light medicine, hyperbaric oxygen, vibration therapy, and hydrogen inhalation to target cellular dysfunction and improve individual wellness. We offer commercial and at-home devices in each of these areas. Today, our technology is available in a rapidly growing network of clinics, anti-aging facilities, and medical spas around the U.S.

Human Touch LLC

Booth #6092

4600 E. Conant St.

Long Beach, California 90808

Ph: (562) 733-7351

Email: healthcare@humantouch.com www.humantouch.com

For over 40 years, Human Touch® has been helping people feel better through our patented, awardwinning, state-of-the-art products that help relieve back pain, stress, and aid in recovery. Developed in cooperation with the medical community and wellness professionals, Human Touch® Massage Chairs and Perfect Chairs are the only chairs recognized by the World Federation of Chiropractic (WFC). Contact Human Touch® today to learn more about our products and our lucrative Healthcare Professional programs.

Humann

Booth #9009

1250 S. Capital of TX Hwy.1-360 Austin, Texas 78746

Ph: (512) 488-4477

Email: professional@humann.com www.pro.humann.com

Humann is committed to promoting cardiovascular health, including healthy blood pressure, cholesterol, blood flow, and heart health support. Humann brings forth smart, plant-based, and nutrition-forward science in the form of supplements in innovative form factors (powders, chews, gummies, tablets), to meet the demands of modern, health-conscious consumers. Its products are widely used by physicians, consumers, and athletes alike. Humann’s product lines include neo40 Professional, glyNOcalyx and SuperBeets.

Hydro Heal

Booth #2102

1985 Longwood Lake Mary Rd. Ste 1007 Longwood, Florida 32750

Ph: (866) 775-5411

Email: INFO@HYDROHEAL.COM www.hydroheal.com

HEAL FASTER, BOOST ENERGY, REVERSE AGING. Hydro Heal provides molecular hydrogen inhalation therapies to providers and patients to slow, stop and reverse most of the top ten disease states. Our medical grade portable devices are trusted by physicians to deliver a daily concentrated dose of molecular hydrogen to: 1) work as a selective antioxidant to neutralize damaging free radicals systemically 2) permeate into the nucleus of cells to protect their dna from damage 3) supercharge mitichondrial function to accelerate autophagy.

IASIS Technologies, Intl.

Booth #2043

38975 Sky Canyon Drive Ste 105

Murrieta, California 92587

Ph: (951) 894-1045

Email: rehlers@iasistech.com

www.microcurrentneurofeedback.com

IASIS MCN optimizes neurotransmitter production, and unmatched immediate benefits for enhanced wellbeing. Experience unprecedented success in patient outcomes with this powerful device that revolutionizes the way practitioners deliver results. IASIS MCN works swiftly and effectively, even when previous interventions fall short. The patient improvements result in dedicates sessions during which patients witness positive changes, compelling them to return for additional benefits. Achieve a rapid return on investment with positive patient outcomes. Our userfriendly system is easily integrated into your practice.

Illuco USA

Booth #7093

2271 W. Malvern Ave #6 Fullerton, California 92833

Ph: (562) 927-8025

Email: info@illuco.com

www.illuco.com

Illuco’s dermatoscopes and loupes are renowned for precision and clarity. Every facet of optics, from conception to rigorous quality testing and production, is handled with meticulous care. We are proud to bring Illuco’s dedication to craftsmanship to the forefront of dermatology.

IMAET Bioenergetic Technology

Booth #7038

1326 New Seneca Tnpk Ste A4

Skaneateles, New York 13152

Ph: (315) 756-6111

Email: communications@imaet.com www.imaet.com

IMAET is an elite bioenergetic technology that interfaces with the body on the cellular level. IMAET discovers energetic imbalances including epigenetic dysfunction and supports a person’s unique wellness needs with personalized feedback. Harnessing the power of frequencies and quantum healing, IMAET improves genetic function, enhances cellular communication, reduces chronic inflammation, and delivers impactful results for long-term wellness. IMAET is a must-have epigenetic biohacking tool for every anti-aging and wellness practitioner. Family owned and operated in the USA.

Immunocine Cancer Center

Booth #6073

Boulevard Luis Donaldo Coloso (Av Tulum) Manzana 1, Lote 3 Smz. 9

Cancún, Quintana Roo 77504

Ph: (888) 575-2572

Email: care@immunocine.com www.immunocine.com

Welcome to the future of cancer treatment with Immunocine. Backed by decades of research and multiple FDA clinical trials, the Immunocine Dendritic Cell Treatment protocol is a less invasive, more precise way to treat over 20 types of cancer. Our Dendritic Cell Treatment initiates a complete immune response against cancer cells, providing one of the most advanced cancer immunotherapies to the cancer patients of today, seeking the cancer treatment of tomorrow.

Immunosciences Lab, Inc.

Booth #1035

822 S. Robertson Blvd. Ste 312 Los Angeles, California 90035

Ph: (310) 657-1077

Email: immunsci@gmail.com www.immunoscienceslab.com

Immunosciences Lab., Inc. (ISL) is a state-of-the-art clinical reference and research laboratory, a leader and innovator in the field of molecular medicine. Licensed in California and CAP-approved, ISL specializes in utilizing the most highly sensitive and accurate testing methods for detecting lyme disease, autoimmunity, gluten sensitivity and viral infection. ISL’s unique tests have resulted in several patents and are the product of over 4 decades of meticulous training, painstaking research, and extensive clinical laboratory experience.

InBody

Booth

#4099

13850 Cerritos Corporate Dr. Unit C Cerritos, California 90703

Ph: (323) 932-6503

Email: convention@inbody.com www.inbody.com

For over 25 years, InBody has provided in-depth insights for healthcare providers, revolutionizing how body composition and blood pressure are monitored. In seconds, InBody’s non-invasive tests capture essential data that allows you to individualize treatment plans for hormone replacement therapies. You can use InBody’s measurements to discover leading indicators of obesity and metabolic syndrome, such as changes in muscle mass, body fat, visceral fat, intra- and extracellular water, cellular health, and blood pressure.

Infiniwell

Booth #7079

5706 E. Mockingbird Lane #115-404 Dallas, Texas 75206

Ph: (888) 819-4640

Email: shop@infiniwell.com www.infiniwell.com

Science is moving faster. InfiniWell makes it easy to keep pace. With products like BPC-157, DHHB, and cosmetic peptides, InfiniWell is fast-tracking clinical breakthroughs into accessible products for physicians and their patients. In a category that’s too often driven by margin and marketing, Infiniwell is privately owned and driven by patient outcomes. Each product is meticulously sourced and formulated through collaboration with practicing physicians, ensuring real-world efficacy and measurable outcomes.

Innergy Development, LLC

Booth #5061

215 S Mountainlands Dr. Orem, Utah 84058

Ph: (385) 208-9200

Email: info@innergydev.com www.innergydev.com

Brain Science and Alternative Wellness Technologies INNERgy Development Technologies are non-invasive and state-of-the-art tools. Whether you are a clinician or just an individual, our innovative technologies may support you on your journey towards optimal health and wellness. We bring you the latest in technology, with a price tag that you can afford.

Innovision Health Media

Booth #7065

3470 Washington Dr. Ste 102 Eagan, New Mexico 55122

Ph: (651) 251-9623

Email: info@innovisionhm.com www.innovisionhm.com/publications.html

InnoVision Health Media publishes professional and consumer magazines, journals, websites, and newsletters. We serve consumers and professionals interested in integrative, holistic, and natural medicine. Our professional journals contain the latest research, case studies/reports, interviews with industry thought leaders, and breaking news concerning the holistic and integrative health care marketplace. Our consumer titles are focused on assisting readers in living a healthier lifestyle.

Integrative Peptides

#5036

Ph: (310) 978-7711

Email: samuelc@integrativepeptides.com www.integrativepeptides.com

Integrative Peptides, established in 2018, offers highquality peptide supplements designed to meet strict safety and purity standards. The company focuses on providing accessible alternatives to traditional peptide therapies, ensuring rigorous third-party testing and FDA-compliant manufacturing. Their mission is to deliver reliable, innovative products that healthcare providers and consumers can trust, continuously expanding their offerings to meet evolving needs in the peptide supplement industry_.

IntegrativePRP

#

Franklin Avenue Ste 200

Ph: (518) 648-3388

Email: contact@integrativeprp.com www.integrativeprp.com

The IntegrativePRP system is one of the only dualspin systems on the market that also has FDA 510(k) clearance. Not only can the IntegrativePRP system provide PurePRP with a consistent concentration of 7-10X baseline, but it can also perform six different processes including adipose, bone marrow, & PRF and all with only a 7-minute spin. IntegrativePRP provides the necessary support to ensure that you can focus on your patients. Contact our office to get started!

IntellxxDNA

Booth #7085

3410 Far West Blvd Ste 202

Ph: (512) 717-3300

Email: info@intellxxdna.com www.intellxxdna.com

The IntellxxDNA Clinical Decision Support Tool is a genomic research and intelligence platform that provides comprehensive, accessible medical reporting and scientific explanations of an individual patient’s gene functions. With detailed discussions of over 700 SNPs and over 10,000 references, our platform provides clinicians with comprehensive, accessible medical reports and scientific explanations of specific genomic patient data. IntellxxDNA puts the world of medical genomics research and functional medicine interventions at your fingertips.

Lab Testing that Fuels Discovery

Genova offers personalized solutions for understanding gut health, metabolic function, hormone balance, and more.

New! Early and Accurate Detection of Alzheimer’s Disease with p-Tau217

Genova’s Alzheimer’s Assessment (p-Tau217) is a convenient blood test designed to detect Alzheimer’s early by measuring the p-Tau217 biomarker. This advanced assessment empowers patients aged 45 and older to take control of their cognitive health and plan for the future.

Learn more at www.gdx.net.

Visit us at Booth 6027!

Less is More in the Vaginal Microbiome

A healthy vaginal microbiome has:

Know the current composition of the vaginal ecosystem with this valuable addition to your Women's Health toolkit.

Healthcare providers can use BiomeFx™ Functional Vaginal Microbiome Analysis to make informed decisions using the comprehensive report that includes nutrition, lifestyle, and supplement recommendations.

BiomeFx™ Vaginal Health Kit offers an individualized approach to rebalancing the vaginal microbiome!

Scan to learn more!

International Hyperbarics Association

Booth #6036

33 Woodcraft Circle

Madison, Wisconsin 53719

Ph: (562) 309-3163

Email: info@ihausa.org www.ihausa.org

The International Hyperbaric Association was founded with the goal of increasing the awareness of hyperbaric therapy to both the medical community and consumers alike. Through a combination of strategic initiatives, our mission continues today to educate the community at large on the benefits of HBOT and provide accessibility for those in need to improve health and wellness. The IHA offers unique benefits for clinics and consumers as a part of our membership program to provide support and resources.

ION* Intelligence of Nature

Booth #8038

4351 Seminole Trail Charlottesville, Virginia 22911

Ph: (844) 432-5488

Email: info@intelligenceofnature.com www.reseller.intelligenceofnature.com

When it comes to health, Intelligence of Nature (ION*) believes in letting the intelligence of nature lead the way. Sourced from 60-million-year-old-soil, ION* offers a suite of fulvate-powered products to support microbiome balance and overall wellness. Your body’s barriers know what to let in (nutrients) and what to ward off (toxins). But the barriers must be strong. ION* strengthens all your body’s barriers (gut and skin) at a cellular level by reinforcing tight junction integrity. Dig deeper - connect today!

Jaspr

Booth #1129

750

Dallas, Texas 75201

Ph: (800) 300-7265

Email: team@jaspr.co www.jaspr.co

Jaspr is a high-performance air purifier inspired by wildfire restoration, designed to effectively clean air with no fluff or filler. We focus on providing expert, real-world advice to improve air quality, regardless of purchase. With one product, the Jaspr Pro, we emphasize “less is more,” offering a powerful, simple solution. Our 4-pound filter combines prefilter, HEPA, and carbon components, making air capture and maintenance easy and efficient.

Jigsaw Health

Booth

#8102

9035 E. Pima Center Pkwy Ste 4 Scottsdale, Arizona 85258

Ph: (866) 601-5800

Email: help@jigsawhealth.com www.jigsawhealth.com

Since 2005, Jigsaw Health (aka. “The Magnesium People”) has been developing the highest-quality nutritional supplements with a focus on Magnesium featuring Sustained Release Technology (w/SRT®), which controls the release of active ingredients so absorption can happen over time. MagSRT® by Jigsaw Health is America’s #1 Time Release Magnesium® with over 1,000 five-star Amazon reviews (five times more than the second-closest brand) and clinically shown to increase Magnesium in the body.*

Jinfiniti Precision Medicine

Booth #9026

1235 Walton Way Augusta, Georgia 30901 US

Ph: (706) 831-8882

Email: greta@jinfiniti.com www.jinfiniti.com

Jinfiniti is a data-driven, science-based company the provides supplements and biomarker tests that allow users to better formulate their healthspan expansion programs. The company was founded by a research scientist, Dr. Jin-Xiong She, a genomic scholar, Professor, and author of more than 400 published papers. Their products are offered by leading anti-aging practices, and functional medical and chiropractic clinics.

Jona

Booth #1095

2299 Summer St. Ste 1095 Stamford, Connecticut 06905

Ph:

Email: hello@jona.health www.jona.health

Jona puts the latest microbiome science at your fingertips so you can provide your clients with comprehensive, cutting-edge care when optimizing their health. Jona’s advanced AI interprets your clients’ unique microbiome profile alongside the scientific literature to discover signatures of various conditions and symptoms. Using their digital twin technology, Jona builds personalized recommendations on diet, lifestyle, and supplements to help achieve their health goals. Learn more about Jona’s Advanced Gut Microbiome Testing + AI-Powered Analysis at www.jona.health

kadara medical

Booth #8084

301 W. 28th Street, Ste E National City, California 91950

Ph: (775) 297-4778

Email: general@kadaramedical.com www.kadaramedical.com

kadara™ medical leads the biomedical device industry with cutting-edge Disposable Trocar Kits and Reusable Trocar Sets for seamless pellet implantation. Our American-made products are FDA registered, ISO 13485 compliant, and use cutting edge E-Beam sterilization to ensure an unmatched sterility assurance of 10-6, delivering precision and reliability. Empower your practice with kadara medical’s innovative solutions, where quality and performance seamlessly meet superior service. We’re not just raising the standard—we’re redefining it!

Kaneka North America

Booth #8070

6250 Underwood Rd. Pasadena, Texas 77507

Ph: (281) 291-3112

Email: vanessa.reagan@kaneka.com www.ubiquinol.org

Kaneka Nutrients is the premier manufacturer and supplier of Kaneka Ubiquinol®. With over 30 years of manufacturing, safety and clinical experience, Kaneka Nutrients is the preferred provider of Kaneka Ubiquinol® to researchers and brand holders worldwide. Kaneka Ubiquinol® has over 85 clinical studies supporting its use in Cardiac Wellness, Preconception Health, and Healthy Aging. Consider Kaneka Ubiquinol® for patients looking for a naturallyoccurring antioxidant to combat oxidative stress, neutralize free radicals and support adult wellness.

Kashi Clinical Laboratories

Booth #2092

9570 SW Barbur Blvd. Portland, Oregon 97219

Ph: (503) 206-4989

Email: tthomas@kashilab.com www.kashilab.com

Kashi Clinical Laboratories is a fully-accredited lab that specializes in a range of genomic healthcare services from HLA testing for Bone Marrow Transplants to UA /drug testing, genetic testing and now COVID19 testing. Kashi Lab offers a distinctive one-on-one approach in developing laboratory services to meet organization and project requirements. We promote well-being and quality of life by delivering the highest standard of laboratory work. We recognize our service as more than a test result.

Diagnostics

Ph: (617) 933-8130

Email: info@kbmodiagnostics.com www.kbmodiagnostics.com

The FIT Test is the most sensitive food test available using patented technology. The multiple pathway approach allows us to look at food sensitivities but also inflammation and gut permeability all from one test. We also provide best in class compliance tools including a personalized meal plan and a patient app. We have an FDA Registered and ISO 13485 compliant manufacturing facility as well as a CLIA High Complexity Laboratory based near Boston, Massachusetts.

KeyCity Capital

Booth #5032

1211 S White Chapel Blvd South

Ph: (817) 912-1569

Email: info@keycitycapital.com www.keycitycapital.com

KeyCity Capital is a financial services company that specializes in private equity investments in real estate and strategic alternative investments. Our team leverages its operational expertise and financial acumen with the goal of capitalizing on investment opportunities and creating long-term value for its investors. We prioritize the careful stewardship of our investors’ capital in each of our investments. What sets us apart is the individual attention we provide to our clients and our dedication to building relationships based on trust.

Kimera Labs, Inc

Booth

#7101

2810 N Commerce Pkwy Miramar, Florida 33025

Ph:

Email: info@kimeralabs.com www.kimeralabs.com

Kimera Labs is the leading exosome biotechnology laboratory specializing in the production of perinatal mesenchymal stem cell (MSC)-derived ) exosome products used for cosmetic and research purposes.

medical technologies

Kinas Medical Technologies

Booth #7091

2160 Kingston Ct SE Ste D

Marietta, Georgia 30067

Ph: (770) 612-8245

Email: info@kinasmedical.com www.kinasmedical.com

Kinas Medical Technologies is a family-owned and operated business providing modern regenerative technologies to healthcare practitioners. We specialize in extracorporeal shock wave (ESWT) and magnetotransduction (EMTT) solutions including The Miracle Wave and STORZ Medical reputable product lines. With over 30 years of industry experience and knowledge, Kinas Medical pairs progressive shock wave technologies with partner-minded customer service for unparalleled implementation efficacy, ongoing support, and continuing education.

Klotho Skin

Booth #2042

655 Redwood Highway Ste 160 Mill Valley, California 94941

Ph: (310) 874-8706

Email: info@klothoskin.com www.klothoskin.com

Klotho Skin is a biotech company introducing an innovative skin care line. Our patented process utilizes mesenchymal stem cells genetically modified to upregulate the age suppressor gene Klotho. We have the first and only viable human cell line modified to produce second generation growth factors and the Klotho protein. Our cellular studies suggest Klotho Skin reverses skin atrophy and increases type IV collagen after exposure to UVB insult. Klotho Skin is regenerative, protective, and preventative.

Koncentrated K

Booth

#1088

535 Delta Ave

Manistique, Michigan 49854

Ph: (715) 612-5858

Email: koncentratedk@yahoo.com www.k-vitamins.com

Vitamin K is an indispensable vitamin, and many people are deficient. Our website summarizes the peerreviewed research on vitamin K and the vital role that Vitamin K and its derivatives, play in the well-being of the body. Koncentrated K contains a therapeutic dose of several different types of Vitamin K, along with astaxanthin. We also offer our personal experience and knowledge of the health benefits of Vitamin K. L-Nutra

LaserCap Company

5905 Legacy Drive 5th Floor Plano, Texas 75024

Ph: (312) 213-8512

Email: torr@l-nutra.com www.l-nutra.com

At L-Nutra, we’re spearheading a global movement to turn sick care into health care. We believe food – one of the few things you consume continually – is a key to health, longevity and preventing and curing disease. We’re using groundbreaking science and natural, plantbased solutions to prove it. In short, we’re here to change the world and usher in an entirely new kind of proactive health care. This is the nutritech revolution.

26 Alpha Park Cleveland, Ohio 44143 US

Ph: (855) 424-7774

Email: info@lasercap.com www.lasercap.com

LaserCap Company was formed in 2006 by coinventors Michael Rabin, MD, and M.I.T trained optical physicist Dave Smith, PhD, in collaboration with Harvard-based photomedicine expert Michael Hamblin, PhD, and internationally acclaimed hair restoration physician Robert Haber, MD, to develop innovative, light-based devices for the global beauty and health industries, including LaserCap for women and men with thinning hair or at risk for thinning hair, a condition that affects up to 50% of adult women and 80% of adult men.

LeaderMed

Booth

#4098

2557 Route 130 S Ste 3 Cranbury, New Jersey 08512

Ph: (732) 692-3176

Email: kevinchen@ultrasculpt.org www.ultrasculpt.org/

UltraSculpt is a brand under LeaderMed Group, offers a comprehensive range of wellness and health management solutions. With a focus on weight loss, anti-aging, nutrition supplements, and more, UltraSculpt aims to provide effective products for enhancing overall well-being. With its diverse product offerings, UltraSculpt provides individuals with a comprehensive approach to wellness and health management. By combining advanced technology, innovative formulations, and a focus on customer well-being, UltraSculpt strives to support individuals in achieving their health and beauty goals.

Life Support Health Products

Booth #7060

800E. 101st Terr. Ste 100 Kansas City, Missouri 64131

Ph: (816) 673-1230

Email: info@lifesupporthp.com www.lifesupporthp.com

As a company, we seek to create the highest quality supplements that exist in the world. All products are created by a functional medicine doctor who is currently in practice. We have solved the problem of having to take too many pills by creating concentrated products that deal with all aspects of a patients biochemistry. We know compliance is key for a patient to get a result and start referring. Let the healing begin.

LightStim

Booth #5085

16552 Von Karman Avenue Irvine, California 92606

Ph: (949) 502-4088

Email: info@lightstim.com www.lightstim.com

Throughout the past 25 years LightStim has earned a reputation as a trusted manufacturer of the highest quality, most innovative light therapy devices in the world. Used in wellness, medical, aesthetic, and fitness focused businesses, LightStim devices are designed and engineered utilizing our unique patented technologies for superior efficacy and utmost reliability. All devices are FDA cleared and US manufactured by LightStim to ensure the highest level of manufacturing standards and quality control.

Lightwave LED

Booth #6043

2205 W Lone Cactus Dr Ste 11 Phoenix, Arizona 85027

Ph: (480) 751-1060

Email: info@lightwavetherapy.com www.lightwavetherapy.com

LIGHTWAVE has been an innovator and industry leader of professional light therapy systems for since 2002. Our professional LED systems offer 5 FDA clearances for the effective reduction of inflammation, wrinkles, acne, pain and pigmentation. LIGHTWAVE’s treatments are accomplished without pain, negative side effects or down time and can easily be incorporated into treatment room. The ENVY Light Capsule LED bed offers both Red and Infrared to address pain, healing, anti-aging and wellness concerns.

2534 Anthem Village Dr. Ste 110

Ph: (866) 790-2107

Email: service@livonlabs.com www.livonlabs.com

LivOn Labs is the first dietary supplement company to utilize liposomal encapsulation technology, releasing the original liposomal Vitamin C in 2004. Our patented Lypo-Spheric® technique encapsulates nutrients — which are ordinarily difficult to absorb when taken orally —in double-layer spheres (liposomes) that pass through the intestinal wall and into the bloodstream. Based in Las Vegas, the family-run company now has distribution in more than 70 countries.

Longevity Labs / spermidineLIFE

Booth

#1123

1550 Wewatta St. Ste 200 Denver, Colorado 80202

Ph: (303) 590-3507

Email: contact@spermidinelife.com www.spermidinelife.us/

At Longevity Labs+, we are researchers with a shared passion for science and the firm belief that we can all take control of our health. spermidineLIFE® is the world’s first non-GMO, organic, nutritional supplement with a high spermidine content to activate autophagy and promote cell renewal for a longer and healthier life. spermidineLIFE® is the result of a decade of research, and is the only spermidine supplement that has been tested in human clinical studies for safety and efficacy.

Luna Medical Technology

Booth

#3091

8350 NW 52nd Terr Ste 301

Doral, Florida 33166

Ph: (916) 846-6781

Email: alexsoto@lunaesthetic.com www.lunaesthetic.com

World leader in the development of cosmetic laser devices.

Maison Beljanski

Booth #2090

317 East 53rd St

New York, New York 10022

Ph: (212) 308-7066

Email: info@maisonbeljanski.com www.maisonbeljanski.com

Maison Beljanski builds on over 40 years of pioneering environmental medicine research by Dr. Mirko Beljanski. Bringing together science and nature to develop unique, tested formulas that promote health and well-being. Beljanski’s discoveries, along with ongoing research by the Beljanski Foundation and its academic partners, continue to drive the innovation behind the Beljanski® Products. Visit us at booth #2090 to discover their full potential.

Marina Pointe Booth #2118

4900 Bridge Street Tampa, Florida 33611 US

Ph: (813) 930-9800

Email: info@marinapointe.com www.marinapointe.com

Enjoy elevated Gulf Coast living at its finest with two new waterfront Towers, 267 thoughtfully designed condominiums, 7 Harbour Homes all with exceptional resort style amenities including a private marina situated on Tampa Bay’s most exclusive deepwater yacht basin. Towers II & III preconstruction pricing available from the high 700s.

MaxGen Labs

Booth #1050

170 E Main St. Ste D

Ph: (832) 683-1574

Email: help@maxgenlabs.com www.maxgenlabs.com

MaxGen Lab was created by practicing physicians to provide a safe, accurate, and easy-to-understand way for people to learn about their bodies. Our reports are based on cutting-edge research, trusted by hundreds of physicians worldwide, and have received rave reviews and success stories. All of our reports contain actionable steps with easy-to-understand and implement results. Our simple and precise DNA tests have helped thousands of individuals make more proactive choices toward optimal health and healing.

McArthur Insurance Agency, Inc.

Ph: (727) 593-0398

Email: Scotth@McArthurAgency.com www.mcarthuragency.com

McArthur Insurance Agency, is an independent agency that has been representing our clients for 30 years. Licensed in 46 states McArthur Insurance Agency has grown into a leader among the specialists in professional liability insurance. We utilize the flexibility of being an independent agency and working with more than 40 carriers ensure you are getting the best possible rate of coverage for your specialty.

McGuff Company Inc.

MDBio - The Doctors Brand™ Booth #8037

Ph: (800) 854-7220

Email: answers@mcguff.com www.mcguff.com

McGuff is the one-stop shop to grow your practice. We pride ourselves on providing our healthcare customers with high-quality, competitively priced products quickly, along with the support of our knowledgeable and friendly customer service team. Orders are processed the same day and shipped free, three-day nationwide. Our most popular products include oral and injectable pharmaceuticals, medical devices, IV supplies and solutions, as well as clinic and exam room supplies. We have the only FDAapproved Ascorbic Acid Injection, ASCOR, (vitamin C).

Ph: (800) 447-1485

Email: hello@mdbiowellness.com www.mdbiowellness.com

MDbio – The Doctors Brand™ is America’s leading provider of clinically proven nutraceutical solutions for sleeplessness, anxiety, and pain management. Founded by four renowned doctors affiliated with UCLA, MDbio combines science-backed formulas with innovative, tech-driven patient tracking to deliver effective therapeutic results.

Med Results

Booth #7064

1111 N Brand Blvd Ste 350

Glendale, California 91202

Ph: (818) 396-4496

Email: info@med-results.com www.med-results.com

Med Results, a top leading provider of aesthetic medical equipment, showcases Plexr Plus at A4M—a noninvasive skin tissue removal device using innovative plasma technology. Our collaboration with A4M underscores our commitment to advancing the aesthetic industry. We aim to connect with professionals prioritizing exceptional results, providing pioneering technologies for cosmetic procedures. Explore the future of aesthetic medicine with Med Results at A4M.

Medeia

Booth #1034

7 W. Figueroa St. Ste 215 Santa Barbara, California 93101

Ph: (800) 433-4609

Email: info@medeia.com www.medeia.com

Benefits all Medical Branches Including Neurology, Primary Care, Cardiology, Pulmonology, Endocrinology, Pain Management. Since its inception in 1992, Medeia Inc has been on the forefront in the manufacture and distribution of Neuro Diagnostic and Heart Rate Variability / ANS products. Medeia Inc specializes in the development of state of the art biometrical software and hardware products intended to monitor physiology.

Tech

Booth #8072

2700 Hall Place

Longview, Texas 75604

Ph: (800) 780-8826

Email: themedicaltech@gmail.com www.themedicaltech.net/

We provide top-quality medical services, The technical team of Medical Tech Medical Services produces high-end revolutionary medical devices for the currently operating healthcare industry and even offers optimum quality services to customers. Our range of products includes medical devices like Ozone Sauna, Narrowband UVB Phototherapy, Capsule.

MediZap

Booth #8086

301 W. 28th Street Unit F National City, California 91950 US

Ph: (775) 386-6677

Email: customerservice@medizap.co www.medizap.co

MediZap, the first and only E-Beam|X-Ray terminal sterilizer for compounders, offers a comprehensive Four-Pillar Service: Advanced Sterilization, Packaging Solutions, Compliance, and Exclusive Partnerships. We ensure 48-hour processing, dedicated capacity, extended BUDs, and a compounding center of excellence. Adhering to USP 797 and cGMP guidelines, our advanced technology guarantees a low-risk 10-6 SAL, providing the safest drug products to hospitals, practitioners, and patients.

MEDICAL MARVEL MASSAGE CHAIRS LLC

Medical Marvel Massage Chairs, LLC

Booth #9027

72 Drinkwater Rd.

Exeter, New Hampshire 03833

Ph: (Sco) ttP-hilo

Email: morphscott@comcast.net

www.medicalmarvelmassagechairs.com

Luxury massage chairs

Medyca Cell - Medyca Bosques

Booth #2119

Azores 780, Colonia Vista Hermosa Monterrey, Nuevo Leon 64620 MX

Ph: (52)(818) 138-3044

Email: inforebiocell@medycabosques.com www.medyca-bosques.com

At Medyca Bosques we are proud to have a highly qualified team to provide doctors and patients with the quality and warmth that characterizes us. Our treatments involves, functional, regenerative and lifestyle medicine within the facility in order to achieve the best outcome. All treatments are personalized and hand in hand with our interdisciplinary team. Our services include: physicians visit, supplementation plans, lifestyle and well-being, stem cell therapy, functional medicine, physical therapy and our experts in the use of orthobiologics.

Medical

Advanced Sterilization

Meridian Valley Lab

Booth

#9090

6839 Fort Dent Way Ste 206 Seattle, Washington 98188

Ph: (855) 405-8378

Email: info@meridianvalleylab.com www.meridianvalleylab.com

A Trusted Leader in Urine Hormone and Food Sensitivity Testing At the forefront of innovation since 1976, Meridian Valley Lab was one of the first to offer urinary hormone and comprehensive, serum-based, food sensitivity testing. Urinary hormone testing revolutionized bioidentical hormone replacement therapy, allowing for the accurate assessment of hormonal levels during treatment. Blood-based food sensitivity testing radically transformed dietary assessments, quickly and easily identifying problematic foods. At Meridian Valley Lab, we empower your patients’ health through our state-of-the-art testing.

Merit Pharmaceutical

Booth #4037

2611 N. San Fernando Road Los Angeles, California 90065

Ph: (323) 227-4831

Email: solutions@meritpharm.com www.meritpharm.com

Offering IV Infusion from Merit? Getting your med/ surg/pharma from us? Your colleagues are and they have higher profits. Merit supplies Anti Aging/ Aesthetic/Integrative practitioners better prices on the products you use. Stop by our booth and learn why successful clinics partner with Merit. IV Therapy Nutrition/Hydration, Weight Loss, Hormones, IV solutions, PRP products, exam/surgical supplies and more. Merit offers pharmaceuticals (2, 3, 3N, 4), and related medical products. www.meritpharm.com or (800) 69-MERIT!

Metabolic Maintenance

Booth #7067

601 N. Larch St. Sisters, Oregon 97759

Ph: (800) 772-7873

Email: info@metabolicmaintenance.com www.metabolicmaintenance.com

After four decades of innovative production, Metabolic Maintenance is one of the longeststanding family-owned companies in our industry of professional nutritional supplements. Metabolic Maintenance is dedicated to the production of clean, science-based nutritional supplements that support optimal health and longevity for life. Science, third-party testing, and innovation are the core components of Metabolic Maintenance’s pure formulations for nutritional supplements.

Metagenics

25 Enterprise Ste 200

Aliso Viejo, California 92656

Ph: (800) 692-9400

Email: Info.customerservice@metagenics.com www.metagenics.com

Metagenics was founded on a revolutionary idea: Our genes do not predetermine our health potential, and through nutrition, we can impact how our genes express themselves. Embodied by our company motto—genetic potential through nutrition—this groundbreaking principle drives us to deliver highquality, science-based nutritional supplements, medical foods, and lifestyle programs to support healthcare practitioners in their efforts to help patients achieve their health and wellness goals.

MHC Medical Products

Booth #7127

8695 Seward Rd. Fairfield, Ohio 45011

Ph: (513) 207-5590

Email: jsmith@mhcmed.com www.mhcmed.com

The Trusted Brand in Healthcare MHC Medical Products designs high-quality consumer diabetic and medical products that provide savings to the end user and greater profits to independent retailers and distributors. Over time, MHC Medical has turned its brands, like EasyTouch® and SureLife®, into household names; trusted and recommended by healthcare professionals and home health users across North and Central America.

Microbiome Labs

Booth #3009

77 Perrys Chapel Church Rd Franklinton, North Carolina 27525

Ph: (904) 940-2208

Email: info@microbiomelabs.com www.microbiomelabs.com

Microbiome Labs is a company focused on improving health outcomes through the modulation of the gut microbiome. The company was built upon three major pillars: clinical research, education, and product innovation. This unorthodox approach is far and away what continues to set Microbiome Labs apart from the rest of the supplement industry. We strive to create unique and effective solutions that help practitioners change lives all over the world.

miraDry, Inc.

Booth #7108

100 Bayview Circle Ste 360 Newport Beach, California 92660

Ph: (408) 579-8700

Email: Marketing@miradry.com www.miradry.com

miraDry is a leading innovator in non-invasive hyperhidrosis treatment. The miraDry system provides a long-lasting, non-surgical solution for excessive sweating and odor by utilizing microwave energy to selectively target and permanently eliminate sweat and odor glands in the underarm area. With a focus on patient satisfaction and well-being, miraDry is committed to delivering superior results while enhancing individuals’ confidence and quality of life. For more information, please visit miraDry.com.

MitoQ

Booth #7129

220 S Warren St Apt 601 Sycracuse, New York 13202

Ph: (315) 283-3413

Email: cspeach@wbblends.com www.mitoq.com

MitoQ is a positively-charged antioxidant health brand, created with word-first, multipatented biotechnology in New Zealand.

Mitozen Scientific Booth #4091

1014 NEast Ave Sarasota, Florida 34237

Ph: (941) 330-8553

Email: info@mitozen.com www.mitozen.club

MitoZen Scientific offers the most advanced natural medicine and healing through detoxification. We are committed to ethics, honesty, and quality, with a passion for innovation, and a vision to revolutionize health care. Our innovative approach to many diseases inspires us to create our hand-crafted nutraceuticals. We will continue to develop the most cutting-edge products, as it is our responsibility to do so.

Molecular You

Booth #8079

555 Burrard Street 1185

Vancouver, British Columbia V7X 1M8

Ph: (800) 380-1468

Email: marketing@molecularyou.com www.molecularyou.com

Molecular You is the first and only multi-biomarker analytics platform, designed to support providers with early detection of disease in over 26 areas. This AI-powered platform analyzes 250+ protein and metabolite biomarkers and gives practitioners evidence-based lifestyle recommendations to tackle disease risk and promote healthy longevity. Unlike traditional blood work, this panel excels at spotting disease progression early, often before symptoms appear - helping us move from reactive healthcare, to a preventive approach.

Molekule Air Purifiers

Booth #1091

10455 Riverside Drive Ste 100 Palm Beach

Ph: (855) 999-9069

Email: allergy@molekule.com www.molekule.com

Molekule is on a mission to provide clean indoor air to everyone, everywhere. Based on 25 years of research and development, the company’s patented photo electrochemical oxidation (PECO) technology destroys the widest range of pollutants, including VOCs, mold, bacteria, viruses, and allergens, when compared to conventional filters. Molekule’s range of air purification solutions have been reviewed and validated by third-party laboratories, as well as continual internal testing, and its medical-grade products have been granted medical device clearance by the FDA.

Momentus

Booth

#8124

1526 W Ute Blvd Park City, Utah 84098 US

Ph: (801) 712-6081

Email: wholesale@livemomentous.com www.livemomentous.com

We want to ensure that our supplements use the best ingredients possible while striving for better; and to ensure that everything produced is held to the same standard of excellence demanded from Olympic teams and professional leagues. We are all high performers— some of us athletes, but all of us are obsessed with how we get the most from our bodies, live healthier and longer, and show up as our best every day.

Mosaic Diagnostics

Booth #2038

8400 W 110th St 500

Overland Park, Kansas 66210

Ph: (913) 341-8949

Email: allsales@mosaicdx.com www.mosaicdx.com

Mosaic Diagnostics delivers the industry’s most respected diagnostics, research, and educational support providing practitioners with actionable data from a partner they can trust. With over 25 years of experience, first as Great Plains Laboratory and now as Mosaic Diagnostics, we have been at the forefront of functional medicine testing, bringing clarity to complex health conditions and providing practitioner with the tools to create personalized treatment protocols.

Multi Million Dollar Practice and Private Practice Freedom Booth #2044

1604 Lamons Ln. Ste 202

Johnson City, Tennessee 37604

Ph: (843) 957-1196

Email: s.todd@awaremed.net www.mmdp.ai/home-9083

The Multimillion Dollar Practice (MMDP) is a powerful program designed to help healthcare professionals build 7+ figure private practices. Under the MMDP umbrella, Private Practice Freedom (PPF) is tailored for doctors who seek the freedom to run a cash-only practice, offering coaching to achieve work-life balance and success. Additionally, AWAREmed 360 provides a turnkey “business in a box” solution for launching or scaling practices effortlessly. MMDP delivers the strategies and tools to create sustainable multimillion-dollar success.

MyAdvice Booth #9028

1850 West Ashton Blvd. Ste 500

Lehi, Utah 84043

Ph: (435) 575-7470

Email: sales@myadvice.com www.myadvice.com

MyAdvice empowers medical professionals to increase their revenue by attracting and retaining more clients through digital marketing. The platform enables hands-on control and visibility into the performance of online marketing activities, backed by 20+ years of expertise. MyAdvice’s six-stage Pyramid of Success™ provides a proven step-by-step plan for how to implement growth-oriented marketing tactics for the greatest impact, including website design and maintenance, local directories, client reviews, social media, search engine optimization (SEO), and paid advertising. Learn more at myadvice.com.

MyPracticeConnect.com

102

Ph: (561) 631-3901

Email: customerservice@mymycolab.com www.mymycolab.com

MyMycoLab is a laboratory specializing in blood serum antibody testing for mycotoxins. Our laboratory tests for 14 different mycotoxins for both IgG and IgE antibodies for a totla of 28 panels. This is the most precise and accurate method to determine if a person has been exposed to mycotoxins.

Ph: (866) 801-8411

Email: info@mypracticeconnect.com www.mypracticeconnect.com

Elevate your practice with new or additional therapies, or purchase our web-based DEA-certified eRx Platform to streamline ordering from compounding pharmacies. From one central portal, you can prescribe, track, and manage wholesale wellness and lifestyle meds from multiple compounding pharmacies, including peptides, GlP-1s, nutrient injections, hormones, and more. Need help with education, protocols, resources, & ongoing medical support? Our concierge approach gives you everything you need to start quickly, safely, and confidently using our 20+ years of experience.

MyVitalC

#9098

Ph: (713) 234-7250

Email: info@myvitalc.com www.myvitalc.com

Extend Life by 90%? We did! Peer-reviewed and published proof at our booth.

N1o1 by Pneuma Nitric Oxide LLC

Booth #6033

2407 S. Congress Ave. Ste E-134

Austin, Texas 78704

Ph: (512) 554-5619

Email: wholesale@n1o1.com www.n1o1.com

Pneuma Nitric Oxide, LLC, the consumer division of Bryan Therapeutics, Inc., specializes in nitric oxide products. With over 25 years of research led by Dr. Nathan S. Bryan, a global expert in nitric oxide biochemistry and molecular medicine, the company develops and tests products that generate detectable nitric oxide gas. Dr. Bryan pioneered the first solid dose form of nitric oxide. The company’s mission is to revolutionize health through the application and restoration of nitric oxide in the body.

E. Crystal

Pkwy Ste L-901

Ph: (737) 400-5726

Email: info@NBXWellness.com www.nbxwellness.com/web/index

NBX Wellness is a leader in personalized wellness. We develop and market physician-designed, cGMP supplements and genetics tests for medical and wellness practitioners to deliver to their patients. NBX gives providers the ability to offer patients access through a branded eStore, customizable protocols and a simple way to incorporate nutrigenomic testing into their practice. Visit us to learn more about why so many providers trust NBX to help deliver personalized wellness solutions to their patients.

National Hair Loss

Booth #8065

7000 E. Shea Blvd. Ste E-110 Scottsdale, Arizona 85254

Ph: (602) 283-2355

Email: carly@nhlma.com www.nhlma.com

National Hairloss the country’s leading expert’s in hair loss and transplantation. National Hair loss offers concierge programs and advanced therapies for clinics and customers nationwide. Our programs are designed to empower image professionals and businesses with cutting-edge education, offering the most advanced knowledge in aesthetics, nutrition, and hair loss solutions. We provide continuous training on the latest technologies, treatments, allowing practitioners to offer innovative, effective, and comprehensive services to their clients while staying ahead in the rapidly evolving industry.

Natrusolate Americas Inc

Booth

#9032

450 N. Bedford Dr. Ste 208 Beverly Hills, California 90210

Ph: (650) 802-0999

Email: info@Epic-T.com

www.epic-t.com

Experience Epic-T at A4M, the superior natural solution to the global testosterone imbalance epidemic. Unlike medications that suppress natural hormone production, Epic-T works with the body, using the clinically proven fenugreek extract, Testosurge, to naturally elevate free and bioavailable testosterone. This safe, food-based supplement not only boosts testosterone but also supports muscle growth, energy, and overall health—without the risks of traditional hormone therapies. Discover how Epic-T can transform your patients’ lives with results you can trust

SW 7th

Ph: (352) 631-7440

Email: amanda@neobiosis.com www.neobiosis.com

Neobiosis is a biotechnology company focused on the development and manufacturing of innovative perinatal products for research and clinical trials. Our goal is simple: to help redefine the field of regenerative medicine through regenerative science and shape the future of this fledgling industry through meaningful partnerships and collaborations. We are uniquely positioned to help usher in this new era of medicine, which focuses on the potential of perinatal birth tissues including cells, EVs and matrix.

NeuroScience - Sanesco

375 280th Street Osceola, Wisconsin 54020 US

Ph: (888) 342-7272

Email: customerservice@neurorelief.com www.neuroscienceinc.com

A better life starts with a healthy brain. And our passion is helping everybody understand and support their unique neuro-endocrine health with actionable information. As a family-owned leader in brain health since 2000, NeuroScience formulates impactful dietary supplement blends targeting the science behind sleep, stress, mood, energy, and cognitive health. We offer healthcare provider exclusive services to streamline supplement selection, including access to non-invasive laboratory testing for neurotransmitter and hormone activity. Wellness journeys start here.

Neuroveda Health

Booth #3103

1818 Westlake Ave N, Ste 424 Seattle, Washington 98109

Ph: (206) 379-1213

Email: reception@neurovedahealth.com www.neurovedahealth.com

At Neuroveda Health we help you connect the dots in your complex health, anti-aging and Longevity journey, together we’ll explore what can be possible for you and your life. Our Executive Longevity Program (ELP) is a personalized medical program that unifies stateof-the-art modern practices like stem cell therapy, IV Therapy, Ketamine Therapy and plasmapheresis (TPE) with the transformative power of Ayurveda to offer your patients the next evolution of their health.

Newbody Anti Aging International Doctors Group Booth #9110

Guang Ji Road 838 Hong Kou, Chongqing CN23 200434

PRC

Ph: (86) (21) 5588-5000

Email: 197028406@qq.com www.shiduokeji.com

Newbody Anti Aging International Doctors Group is a doctor group jointly established by renowned anti-aging experts, clinical medical experts, and biological scientists from China and overseas. The group is committed to providing better quality of life and a longer life cycle for every awakened life through new life science and medical expertise!

Nextech

Booth #3064

4221 W. Boy Scout Blvd., Ste.350

Tampa, Florida 33607

Ph: (800) 868-3694

Email: meetings@nextech.com

www.nextech.com

Nextech’s med spa-specific software is the industry’s first end-to-end solution that enhances care, streamlines workflows, and empowers business growth. Purpose-built to address the most complex challenges med spas face, Nextech’s solution can simplify your office’s day-to-day. Learn more about how Nextech can help your med spa succeed, visit www.nextech.com.

Noaaon Alliance, LLC

Booth

#2078

848 N. Rainbow Blvd., Ste.8383

Ph: (702) 703-7255

Email: info@noaaon.com

www.noaaon.com

NOA|AON is a purpose driven lifestyle brand that provides online and in-person immersive experiences, retreats, workshops, and holistic products that brings the power back to the people. Our mission is to unify the world one person at a time through ancient and modern tools for happiness, health and harmony. Integrating breath-work, meditation, sound healing, modernized ecstatic dance, and technology with education into the ultimate platform for your journey through self-transformation.

Nordic Naturals

Booth #2103

111 Jennings Drive

Watsonville, California 95076 US

Ph: (831) 566-6664

Email: ttrubey@nordic.com www.nordicpro.com

Nordic Naturals is the #1 selling fish oil brand in the U.S., trusted by healthcare professionals since 1995. Our product portfolio offers the perfect nutritional support for patients. You’ll find highly concentrated Omega-3s, multi-strain probiotics, vitamins and minerals, women’s and pediatric products, and much more!

NOVOS

Booth #3074

100 Park Avenue, Floor 16 New York, New York 10017 US

Ph: (480) 748-9797

Email: sales@novoslabs.com www.novoslabs.com

NOVOS leverages the latest scientific research to offer the most validated formulations, biological age tests, and free resources, empowering you to take control of aging and slow it down. NOVOS, established in 2018, is a pioneer in longevity, reshaping the future of aging and enabling healthier, longer lives. Our mission is to make longevity accessible and achievable for all – not just the ultra-wealthy – empowering all people with comprehensive solutions for a longer, healthier life.

Novus Optimum dba A. Best Supplements

Booth #

6625 S. Valley View Blvd. Ste 222 Las Vegas, Nevada 89118

Ph: (702) 405-7999

Email: novusoptimum.sales@gmail.com www.novusoptimumlab.com

Novus Optimum Lab dba A. Best Supplements is a Dietary Supplements company founded in San Francisco by Meliza Reyes. It has been her lifelong passion to develop wellness accessible to all. Established in 1997, the founder has long since developed formulas that are herbal and natural, which may be significantly beneficial for one’s health.

NuBioAge, LLC

Booth #6085

8144 Okeechobee Blvd Ste A West Palm Beach, Florida 33411

Ph: (561) 223-8174

Email: info@nubioage.com www.nubioage.com

NuBioAge is a pharmacist-led innovation and wellness network that turns deep, scientific knowledge on health and longevity into realworld protocols and practice for physicians. Our mission is to evolve patient care for better aging by leading the conversation with accessible scientific research through continued education, expertly formulated supplements, and longevity thought leadership. We are a connecting hub and expansive resource for physicians and healthcare practitioners to rely on for consistent proactive healthcare alternatives and formulations for their patients.

Nuchido TIME+

Booth #3046

Dissington Hall

Dalton, England NE180AD

Ph: (314) 260-7874

Email: partners@nuchido.com www.nuchido.com

At Nuchido it is our mission to translate the latest scientific breakthroughs into products that slow biological aging and extend healthspan. Nuchido TIME+ is our powerful next-generation NAD+ supplement. Unlike precursor supplements or NAD+ IVs, our patented formulation addresses the root causes of NAD+ decline. Nuchido TIME+ has been proven to boost NAD+, reduce inflammation and reverse biological age, in a double-blinded placebo-controlled crossover study. Nuchido is founded by Dr Nichola Conlon, a molecular biologist specialising in cellular aging.

NuMedica

Booth #7032

9503 E 55 Pl

Ph: (800) 869-8100

Email: mail@numedica.com www.numedica.com

NuMedica® is an NSF® GMP Certified, FDA registered company implementing the latest quality control standards in manufacturing and testing of our formulas. Our formulas are designed with active ingredients for higher performance along with advanced nutrient delivery methods and Enhanced Absorption Technologies™ offering value through increased bioavailability.

Nutrafol Booth #3098

Ph: (888) 908-3858

Email: partners@nutrafol.com www.nutrafol.com/professionals

Nutrafol is a hair growth and skin health supplement brand that pioneered the hair wellness category with its whole-body approach. Nutrafol supplements are physician-formulated with 100% drug-free ingredients, optimized for different bio-specific needs based on an individual’s life stage and lifestyle. As a supplement industry leader, Nutrafol prioritizes a rigorous approach to clinical testing of its skin and hair health innovations and the use of ingredients supported by clinical studies and published ingredient research in their efficacious servings.

Nutramax Laboratories Consumer Care, Inc.

Booth

#6071

946 Quality Dr. Lancaster, South Carolina 29720 US

Ph: (888) 886-6442

Email: contactus@nutramaxlabs.com www.nutramaxlabs.com

Since 1992, Nutramax Laboratories has been at the forefront of scientific innovation, consistently fortifying brands. Rooted in Lancaster, South Carolina, as a family-owned and operated entity, Nutramax Laboratories Consumer Care, Inc. proudly unveils its latest brand—NutramaxTM Practitioner Formulas. This exclusive line was developed for healthcare practitioners, embodying unparalleled quality through top-tier ingredients, state-of-the-art facilities, meticulous clinical research, and over 80 rigorous quality checks.

Trauma-informed care with focus on transference to daily life. complex health & longevity clinic * seattle, WA

Executive Longevity Program

Plasmapheresis (TPE, PLEX)

Stem Cell Therapy (SVF)

Ketamine Psychotherapy

Ayurvedic Medicine

Autologous Exosomes

IV therapy: NAD+, MitoLove

Pranayama Breath Work

Joints: Prolo/ PRP/ Ozone

Neuro20 Muscle-Brain Devo

Safe & Sound Protocol & more

Based on an Ayurvedic panchkarmastyle medical retreat, these 3-21 day custom-designed immersion programs focus on guiding you into the next evoluation of your health.

For whom? Prevention, Treatment & Longevity hEDS, MCAS, ME/CFS, Long-COVID, POTS, PANDAS, Autoimmune. Mystery-syndromes welcome.

NutriDyn

Booth #5043

5414 Hwy.12

Maple Plain, Minnesota 55359

Ph: (800) 444-9998

Email: info@nutridyn.com www.nutridyn.com

For over 50 years, NutriDyn has been a leader in functional nutrition, providing unmatched support to healthcare practitioners. As a proud third-generation, family-owned company, we offer clinically effective, clean formulas rigorously tested for quality and efficacy. We prioritize transparency, trust, and education, offering resources and seminars to keep you informed. Partnering with NutriDyn means joining a family dedicated to enhancing patient outcomes through innovative nutraceutical solutions and continuous practitioner support.

Nutrihealth LLC

Booth #8091

PO BOX 1304

Brookline, Massachusetts 02446

Ph: (401) 216-5043

Email: info@nutrihealthcorp.com www.nutrihealthcorp.com

Nutrihealth LLC is a company dedicated to promoting the health and well-being of our customers. We specialize in offering the best products and nutraceuticals available in the market. Our commitment is to provide high-quality and effective solutions that enhance individuals’ overall health and vitality. Mission: To improve the lives of our customers by providing them with top-notch nutraceuticals that support their health goals. Vision: To be recognized as a trusted and leading provider of innovative and reliable health solutions

NXC Imaging

Booth #4102

1325 Quincy Street NE. Ste A2

Minneapolis, Minnesota 55413

Ph: (800) 328-5016

Email: sales@nxcimaging.com www.nxc-imaging.com

NXC Imaging is a Canon Medical Systems USA company. As the exclusive distributor for QT Imaging in the United States, we are proud to introduce the QTI Breast ACT, an innovative, FDA cleared, technology based on low frequency soundwaves, using true 3D acquisition. Patients deserve a better experience with results they can trust. QT Imaging Breast ACT is an innovative system prioritizing patient comfort and safety by eliminating breast compression with no radiation exposure.

Olympia Pharmaceuticals

Booth #6007

6700 Conroy Road Ste 155 Orlando, Florida 32835

Ph: (407) 250-4000

Email: inquiries@olympiapharmacy.com www.olympiapharmacy.com

Olympia Pharmaceuticals is the nation’s leading FDA-registered outsourcing facility and trusted pharmaceutical provider. With two cuttingedge facilities, Olympia can deliver office-use and patient-specific medications nationwide. Supported by a team of expert pharmacists and a reputation for 5-star customer service, Olympia is the pharmacy you can rely on for excellence and precision. Specializing in dermatology, weight management, IV nutritional therapy, sexual health, longevity, and more, it’s time to choose Olympia as your single-source pharmacy provider.

OMNIWave™

Booth #5027

2980 NE 207th St. Ste 503 Aventura, Florida 33180 US

Ph: (833) 666-4928

Email: ops@omniwave.com www.omniwave.com

OMNIWave™ redefines regenerative therapy with innovative, non-invasive shockwave technology. Our advanced electrohydraulic system accelerates healing, alleviates pain, and enhances well-being. What sets OMNIWave™ apart is its unique retractable bellow technology, allowing for precise control and deeper therapy, optimizing treatment outcomes. With a focus on portability and ease of use, OMNIWave™ empowers providers to deliver high-quality, targeted treatments that improve patient care and help individuals regain a pain-free, active lifestyle. OMNIWave™ is the preferred solution for professionals seeking leading-edge regenerative therapies.

OptioRx

Booth #2045

3701 Commercial, Ste.14 Northbrook, Illinois 60062 US

Ph: (877) 958-1601

Email: info@optiorx.com www.optiorx.com

OptioRx is a network of pharmacies specializing in wellness, weight management, and dermatology. With both sterile and non-sterile compounding capabilities, we customize our formulations to meet individual patient needs and can service the entire United States. Our commitment to quality and innovation ensures that healthcare providers across the country can rely on us for customized solutions. Explore how our products can enhance patient outcomes and support your practice.

OrganoLeaf

Booth #8073

1720 Diplomacy Row

Orlando, Florida 32809

Ph: (407) 730-4137

Email: info@organoleaf.com www.organoleafwholesale.com

OrganoLeaf, a GMP Certified company in Orlando, FL, produces sugar-free allulose nutraceutical gummies and premium hemp-derived topicals. Our gummies, free of sugar and artificial sweeteners, are enriched with essential vitamins and minerals, ensuring optimal health. We prioritize both health and taste, delivering a delectable experience. With state-of-the-art facilities and rigorous quality control, we are dedicated to quality, innovation, and customer satisfaction, offering effective solutions for holistic well-being.

Ortho Molecular Products

Booth #4027

550 W. NW Hwy Floor 2

Barrington, Illinois 60010

Ph: (800) 332-2351

Email: contactus@ompimail.com www.orthomolecularproducts.com

For over 35 years, Ortho Molecular Products has partnered exclusively with health care providers to deliver nutritional solutions of the highest efficacy. The most trusted voices in health care put their trust in our products to help patients get better, faster. Our commitment to science, careful raw ingredient selection, and strict quality standards goes into every supplement we formulate. To learn more, visit www. orthomolecularproducts.com or call 1-800-332-2351.

OxyHealth

Booth #6021

10719 Norwalk Blvd

Santa Fe Springs, California 90670

Ph: (562) 619-2515

Email: events@oxyhealth.com www.oxyhealth.com

OxyHealth has forever changed the way the medical industry practices hyperbaric therapy. Since our inception, we are devoted to providing quality and brilliantly safe portable hyperbaric chambers to physicians, professional athletes, wellness centers, and families. All OxyHealth chambers are designed for patients to easily self-treat, which has fostered a cutting-edge trend in hyperbaric technology.

Ph: (480) 329-4690

Email: HCPINFO@pendulumlife.com www.pendulumlife.com/pages/ healthcareprofessionals

Pendulum is improving the lives of millions by unlocking the power of the gut microbiome with evidencebacked probiotics you can’t find anywhere else.

Personalized Nutrients

Ph: (541) 549-0333

Email: kourtney@personalized-nutrients.com www.freedomtoformulate.com

Personalized and Compounded Nutrients is a nutraceutical company empowering healthcare professionals to create custom formulas for their patients and practices. Compounded Nutrients allows practitioners to formulate low minimum, high quality private labeled products. Personalized Nutrients allows practitioners to create a formula based on a patients individual needs and ultimately eliminating pill fatigue. Both of these options utilize our state of the art online formulator to put the Freedom to Formulate in the hands of practitioners.

Physician Compounding Alliance

#7039

Springview Loop estero,

Ph: (719) 201-9268

Email: twbader@aol.com www.physiciancompoundingalliance

Office Dispensed Compounded Therapies. Physician Compounding Alliance makes it possible for your practice to dispense compounded drug therapies directly from your office to your patients at their point-of-care, improving patient compliance and convenience while increasing your practice’s revenues. Available dosage forms include, but are not limited to: creams, oral/SL/SR tablets, capsules, pellets, suppositories, and troches.

Physicians Lab

Booth #1038

4850 T-Rex Ave. Ste 150

Boca Raton, Florida 33431

Ph: (877) 316-8686

Email: tscaletta@physicianslab.com www.physicianslab.com

Physicians Lab is one of the nation’s leading urinary hormone testing laboratory, delivering State-of-the-art Science with Superior Solutions. We beat the competition in price and turnaroundtimes, while providing accurate, reliable LC/MS/ MS results. With our tools, education and training, we give you everything needed to offer patients convenient, affordable, and error-free testing.

PhysioAge

Booth #7075

30 Central Park South Ste 8A New York, New York 10019

Ph: (212) 776-4956

Email: info@physioage.com www.physioage.com

Biomarkers of Aging An unparalleled and focused array of extensively-tested biomarkers that have been shown to highly correlate with age. Detail and precision are crucial differences that set PhysioAge apart from other health tests. Our expert system is based on solid science – extensive clinical trials, scientific literature, and careful statistical analysis of primary data. Rather than using secondary clinical studies to calculate physiological age, we used our own in-depth primary research to measure 120 attributes among 120 individuals.

PNOE, Inc.

Booth #4061

67 Maplewood St. Malden, Massachusetts 02148

Ph: (650) 485-0872

Email: info@pnoe.com www.pnoe.com

PNO_ revolutionizes health optimization with its clinical-grade breath analysis device, making advanced metabolic testing accessible beyond elite clinics. Trusted by 3,000+ professionals and top athletes, it offers personalized health programs, enhancing client retention and care with minimal effort. Validated by prestigious universities, PNO_ is the choice for non-invasive, instant biometric testing.

Power2Practice

Booth #7072

601 S. Saginaw St., 5th Fl Flint, Michigan 48502

Ph: (855) 677-2502

Email: sales@power2practice.com www.power2practice.com

Power2Practice is specifically designed for functional and integrative medicine. With features such as customized note templates, cash-based billing module/superbills, specialty lab integrations, Fullscript interface, Power2Practice gives you all the EMR capabilities you expect, plus the specialized features you need. Our intuitive patient portal facilitates patient communication, online scheduling, appointment reminders and much more. Plus, with the addition of our newly released Televisit module, Power2Practice streamlines the efficiencies of the charting, front office and patient experience.

PQ Pharmacy

Booth #3114

Ph: (352) 477-8977

Email: info@pqpharmacy.com www.pqpharmacy.com

FDA Registered 503b Outsourcing Facility of compound manufactured pharmaceuticals

Precision Epigenomics

Booth #8115

630 N. Alvernon Way Ste 280B Tucson, Arizona 85711

Ph: (520) 372-7522

Email: info@precision-epigenomics.com www.precision-epigenomics.com

Precision Epigenomics is committed to transforming healthcare with cutting-edge technology that identifies the deadliest cancer types at their earliest stages through a simple liquid biopsy. The EPISEEK™ test is designed to accurately assess DNA shed by tumors called “circulating tumor DNA” (ctDNA). EPISEEK™ interrogates cancer-specific aberrant DNA methylation cell-free DNA, targeting a proprietary set of biomarkers that reliably indicate the presence of cancer (this molecular signature is not found in normal cells).

Precision Point Diagnostics

Booth

#7104

9 Dunwoody Park Ste 122

Dunwoody, Georgia 30338

Ph: (678) 736-6374

Email: info@precisionpointdiagnostics.com www.precisionpointdiagnostics.com

Precision Point Diagnostics is an innovator of testing solutions that assist in the diagnosis and management of conditions commonly addressed by Functional Medicine. Our unique profiles are designed to help you develop comprehensive approaches to patient care. Our Services include Diagnostic testing of the GI tract, Immune System, Hormones, Toxins, Nutrition Markers, and Inflammation. The Educational programs we offer enable an easy implementation of our testing into your practice. Learn about Medicare coverage.

Prestige Products Direct

Booth #1049

12440 SW 117 Ct. Miami, Florida 33186

Ph: (305) 234-8081

Email: triaddirect@gmail.com www.triadaer.com

Triad Aer. Professional Air Purification system

Prism Light Pod

Booth #4079

13303 E. Adams Aircraft Circle Englewood, Colorado 80112

Ph: (720) 231-5384

Email: infoprismlightpod@gmail.com, www.prismlightpod.com

Prism Light Pod is the industry’s leading producer of whole-body red light therapy solutions for the natural health and wellness industry. We design and manufacture the most-innovative and award-winning red light therapy solutions for maximizing energy and wellness throughout the body. Prism Light Pod has the most-powerful and energy-efficient wholebody red light therapy systems that offer natural solutions to relieve chronic pain and inflammation, aid in weight loss and anti-aging, and accelerate the body’s natural recovery process 4-10 times.

Procell Therapies LLC

Ph: (855) 577-6235

Email: nate.henkel@procelltherapies.com www.procelltherapies.com

Procell Therapies offers cutting edge biotechnology that transforms the skin and hair safer than ever before. With a patented “Microchanneling” device and combination of human derived growth factor serums, profound results are possible for treating a broad range of skin types and conditions as well as hair restoration.

Prodrome Sciences

#3071

27518 Vía Industria Temecula, California 92590 US

Ph: (951) 228-4222

Email: info@prodrome.com www.prodrome.com

Prodrome Sciences is a specialty blood test laboratory, supplement manufacturing, and research company. Founded by Dayan Goodenowe, PhD, our products are the result of extensive evidence from large clinical studies of thousands of blood samples from around the world. Prodrome researches and develops solutions to prevent disease, restore health, improve vitality, and achieve longevity.

Professional Health Products

#1052

PO Box 97227 2104 Babcock Blvd. Pittsburgh, Pennsylvania 15209

Ph: (412) 760-1115

Email: hlord@phpltd.com www.phpltd.com

Cutting corners when it comes to quality is an all too common practice in the supplement industry. We at PHP have been committed to using the highest quality ingredients, backed by science, in our formulations since our beginning in 1978. Our integrity and ingenuity goes into every product in our comprehensive line; making the partnership we have with clinicians above industry standard.

ProgenaBiome

Booth #6042

1835 Knoll Dr.

Ventura, California 93003

Ph: (805) 339-0549

Email: jeff@progenabiome.com www.progenabiome.com

Progenabiome is a genetic sequencing research laboratory dedicated to continuing the work of the late Dr. Sydney Finegold, a man who recognized the power of anaerobic bacteria and spent his life correlating microbes to diseases. Our mission is to crack the genetic code of a trillion bacteria, fungi and viruses that live in our gut. We hope to find cures to diseases that we feel are caused by alteration of the gut flora.

Progressive Laboratories, Inc.

Booth #9037

3131 Story Road West

Irving, Texas 75038

Ph: (972) 518-9660

Email: sales@progressivelabs.com www.progressivelabs.com

For over 50 years we have been dedicated to delivering science-based nutraceutical products that maximize the potential for health and wellness, providing nutritional support your patients need. We are a GMP and UL certified manufacturer of 200+ products that can be private labeled. Our in-house graphics team will create and print your personalized label. We also do contract manufacturing if you would like to create your own formula.

ProHealth, Inc.

Booth #8042

555 Maple Ave.

Carpinteria, California 93013

Ph: (800) 733-1658

Email: healthcare@prohealth.com www.prohealth.com

At ProHealth Longevity, we are committed to being your trusted partner in promoting a healthy lifestyle. Since 1988, ProHealth has provided Physicians & consumers with top-quality supplements that are rigorously 3rd party tested to guarantee purity, potency, and efficacy. Becoming a ProHealth Longevity Healthcare Partner comes with the necessary tools and resources for success. You can purchase at wholesale prices or earn a generous commission every time your clients purchase. Join us today

Protocol For Life Balance

Booth #9055

Knollwood Drive Bloomingdale, Illinois 60108

Ph: (877) 776-8610

Email: Sales@protocolforlife.com www.protocolforlife.com

Protocol For Life Balance is a well-researched, potent, and efficacious brand of high-quality dietary supplements and natural products sold exclusively through licensed healthcare practitioners. Protocol For Life Balance offers many unique formulas and products, that come with a money -back guarantee if any patient is less than 100% satisfied. Our mission is simply to provide quality products that lead to healthy patients and satisfied physicians. Family Owned and Operated. www.protocolforlife.com 877-776-8610

PRP Science MD

Booth #7063 1424 Sumter Lane

Ph: (561) 892-6638

Email: danny@prpsciencemd.com www.prpsciencemd.com

At PRP Science MD, we specialize in regenerative biologics, FDA-approved medical equipment, and cosmeceuticals. We offer innovative treatment solutions in aesthetics, hair regrowth, sexual health, weight loss, and supplements. Our portfolio includes state-of-the-art PRP therapy equipment, enabling physicians to provide advanced patient care. Our commitment is to enhance healthcare treatment options through high-quality products and equipment.

PulsePEMF

Booth

Ph: (702) 443-9554

Email: tbutler@pulsepemf.com www.pulsepemf.com

PUR-FORM

Booth #5046

3600 FAU Blvd Ste 101

Boca Raton, Florida 33431

Ph: (908) 894-0035

Email: mdoran@purformhealth.com www.purformhealth.com

PUR-FORM, led by industry pioneer Joseph Purita, MD, trains physicians and their clinics worldwide on EBO2 (extracorporeal oxygenation and ozonation), VSELs (very small embryonic-like stem cells), and regenerative orthopedic procedures. PUR-FORM’s protocols are best-in-class, taught by world leaders.

Pure Encapsulations

Booth

#3100

490 Boston Post Road

Sudbury, Massachusetts 01776

Ph: (800) 753-2277

Email: customerservice@PureEncapsulations. com

www.pureencapsulationspro.com

We’re Pure Encapsulations®, the #1 most recommended professional supplement brand by healthcare professionals.1 Our products are backed by verifiable science, tested for purity and potency, and formulated using high-quality, pure ingredients FREE FROM unnecessary additives, and many common allergens. That’s goodness encapsulated. 1. Among U.S. healthcare professionals surveyed who recommend specific professional supplement brands; Nutrition Business Journal® Practitioner Survey 2016, 2020, 2023

Push Patch

Booth #9020

3683 Garden Court Grove City, Ohio 43123

Ph: (850) 733-9131

Email: contact@pushpatch.com www.pushpatch.com

High-dose NAD+ patch without the needles. Push Patch delivers NAD+ and NAD+ combinations via slow release, direct to bloodstream with the iontophoresis technology.

Qest4

Booth

#6039

70 W. Canyon Crest Road. Ste 100 Alpine, Utah 84004

Ph: (801) 209-2454

Email: nate@qest4.com www.qest4.com

Pursuing Wellness, Cultivating Vitality Here at Qest4, we are committed to providing wellness practitioners with all the resources they need to run a successful practice, that gives the best care and results for their clients.

Qualgen

#2117

301 Enterprise Dr. Edmond, Oklahoma 73013 US

Ph: (405) 241-4006

Email: ABACCUS@Qualgen.us www.qualgen.us

Qualgen is an FDA registered 503B outsourcing facility with state-of-the-art sterile labs that meet cGMP requirements. Qualgen has a wide range of compounded bio-identical estradiol and testosterone hormone pellets. Qualgen offers same-day shipping, easy account set up and superior customer service.

Qualia Booth #6037

2011 Palomar Airport Rd Ste 101 PBM 160 Carlsbad, California 92011 US

Ph: (858) 243-5479

Email: partners@qualialife.com www.qualialife.com

Qualia Life Sciences was established in 2015 to enhance the quality of life through cutting-edge wellbeing formulations. Their science team emphasizes the principles of naturopathy and has pioneered formulation techniques using complex systems science, which recognizes the body’s inherent selfregulation capacity as a key factor in addressing various health issues. Their expanding product lineup addresses a wide variety of health needs, such as aging, brain health, senescent cells, sleep, skin, and energy, with many products under development.

Booth

Quantum Biotechnology Corp

Booth #8112

630-1231 Pacific Boulevard

Vancouver, British Columbia V6Z0E2

Ph: (604) 353-1738

Email: support@qilifestore.com www.qilifestore.com

Quantum Biotechnology Corp., also known as Qi Life, is a pioneer in combining quantum technology with biotechnology for health and wellness. We develop innovative products and services that use quantum frequencies to enhance vitality, balance, and well-being. Our solutions are designed to support holistic health without invasive methods, offering a new approach to wellness. By merging science with advanced technology, Quantum Biotechnology Corp. is redefining how people manage energy and achieve optimal health naturally.

Quartermaster Tax

Booth #7042

125 Floyd Smith Office Park Drive Ste 221 Charlotte, North Carolina 28262

Ph: (704) 490-4111

Email: info@quartermastertax.com www.quartermastertax.com

Quartermaster Tax Management is a proactive tax management firm that elevates our clients’ financial well-being through collaborative services designed to reduce taxes, increase revenue, profits and net worth, through proactive tax planning and Research & Development credits.

Quest Diagnostics

Booth #6047

6701 Carnegie Ave. Cleveland, Ohio 44103

Ph: (216) 767-3638

Email: Diane.Downing@Impact-XM.com www.questdiagnostics.com

As the world’s leading provider of diagnostic information services, Quest Diagnostics and all our employees are committed to The Quest Way, sharing our purpose, strategy, and culture—through working every day to uncover important insights about your health. We’re dedicated to providing actionable results that empower you with the information you need to make your healthcare decisions.

Quicksilver Scientific

Booth #7013

1960 Cherry St LOUISVILLE, Colorado 80027

Ph: (303) 531-0861

Email: support@quicksilverscientific.com www.quicksilverscientific.com

Quicksilver Scientific® is a leading manufacturer of advanced nutritional systems with a focus on detoxification. We specialize in superior liposomal delivery systems and heavy metal testing to support optimal health. Our advanced liposomal supplements are highly absorbable and support the body in the elimination of the broad range of toxins we’re exposed to. We are passionate about health and well-being and are committed to improving the lives of everyone we touch.

Qunol - Quten Research Booth #7071

10 Bloomfield Ave, Building B Pine Brook, New Jersey 07058

Ph: (561) 660-1409

Email: kim.hassett@qunol.com www.qunol.com

Specializing in CoQ10, Turmeric, Magnesium, and Omega 3 Fish Oil Supplements.

Rapid Release™ Technology

Booth #7098

3303 Harbor Blvd. Ste D10 Costa Mesa, California 92626

Ph: (949) 415-4778 ext 1

Email: info@rapidreleasetech.com www.rapidreleasetech.com

Rapid Release Technology provides a commercial grade and consumer vibration therapy technology used by professional athletes and practitioners for fast, full-body muscular pain relief. Unlike percussive devices (massage guns), vibration therapy may be used on areas percussive therapy cannot treat, such as the cranial, spinal column, TMJ, bony prominences and tendons. Request a demo today. A few minutes is all it takes to experience pain relief and relexation.

Recharge Biomedical

Booth #8090

3980 Wilshire Blvd Unit 735 Los Angeles, California 90010

Ph: (714) 369-8633

Email: drpark@rechargebiomedical.com www.rechargebiomedical.com

Dr. Edward Park provides state-of-the art regenerative medicine using stem cell exosomes in five states (CA, NY, FL, TX, HI) He is also the leading authority in the clinical use of exosomes and is an internationally invited speaker on the subject. He is the author of “Exosomes: Songs of Healing” and created an online provider training course at www.rechargebiomedical.com/courses

Redd Remedies

Booth #7087

211 S. Quincy Ave. Bradley, Illinois 60915

Ph: (888) 453-5058

Email: customercare@reddremedies.com www.reddremedies.com

Everyone wants to feel good, but most of us don’t. Through fusion of wholesome clean foods, guidance from our Master Herbalist & other natural health professionals, and our expertly crafted supplements , we address health from a whole body perspective and help you feel better. Redd Remedies help people put their health in order and achieve life-changing results.

ReeLabs Private Limited

Booth #6103

1st floor, K.K. Chambers Sir P.T. Road, Fort Mumbai, Maharashtra 400001

Ph: (91)9820180076

Email: customer.support@reelabs.com www.reelabs.com/anti-ageing

ReeLabs has devoted the past decade to establish itself as a recognised authority in the field of stem cells and regenerative medicine. ReeLabs is a pioneer in collection, separation and utilisation of stem cells. It is the only company in India offering stem cell separation and storage from 10 different biological sources available, including placental stem cells. ReeLabs’ patented Golden Vial Program quantifiably helps in rejuvenating the body clock and thereby reducing the biological age by up to 20 years.

Refine USA

Ave South Ste C

Ph: (904) 240-4269

Email: support@refineusa.com www.refineusa.com

Refine USA, LLC located in Jacksonville, FL has been a market leader in the manufacturing and distribution of premier aesthetic technologies for more than 18 years. We pride ourselves on designing and developing medical devices that meet the clinical and financial needs of aesthetic health care providers. The FDA Cleared Rejuvapen NXT® Microneedling System, the PureSpin® PRP System and the Facelite USA LED Series are just a few examples of our “market-changing” technologies.

Regen Pod

1030

Street

Ph:

Email: nick@regenpod.com www.regenpod.com

ReGen Pod specializes in cutting-edge photobiomodulation technology, offering advanced light therapy solutions for wellness and recovery. Our innovative devices harness specific wavelengths of light to promote healing, reduce pain, and enhance overall well-being. Trusted by professionals and individuals alike, ReGen Pod delivers effective, noninvasive treatments that empower users to achieve optimal health naturally and efficiently. Experience the future of light therapy with ReGen Pod.

Regenative Labs

Booth #4047

1700 W Main St Ste 500 Pensacola, Florida 32502

Ph: (850) 501-9062

Email: info@regenativelabs.com www.regenativelabs.com

Regenative Labs produces regenerative medicine products to address the root cause of a patient’s conditions using Wharton’s jelly innovations rather than masking pain. Regenative Labs works closely with scientists and physicians to monitor and improve patient progress and outcomes while following FDA guidelines of minimal manipulation for homologous use.

Regenere

Booth #2047

3521 Leonard Ct.

Santa Clara, California 95054

Ph: (866) 364-0963

Email: events@vibrant-wellness.com www.regenere.com

Revitalize your skin with Régénère, a personalized skincare solution crafted from your unique genetic profile. Begin with an at-home saliva test, followed by an in-depth skin assessment, including a photo analysis. Receive custom peptide-based formulations free of toxins, mycotoxins, parabens, and heavy metals. Experience anti-wrinkle, anti-sagging, and brightening

Email: Roxanne@rejuvenation-science.com www.rejuvenation-science.com

Sophisticated supplements for integrative, regenerative and functional medicine practices begin with top-rated Maximum Vitality multivitamin. Promoting MMM Theory: A New Paradigm in Medicine, defining the root cause of inflammation and protocols to prevent, treat, test, and monitor treatment effectiveness rather than treatment of symptoms which are the body’s natural protective action against environmental microcontaminants by supporting the human microbiome and binding, degrading and removing microcontaminants. Please chat with us to understand our quality, knowledge, integrity, and attention to individual clinicians.

REGENmax

Booth #2065

6225 Colleyville Blvd Ste 100 Colleyville, Texas 76034

Ph: (214) 558-2905

Email: jnuziard@swcofusa.com www.regenmax.com

Only Patented CURE for Erectile Dysfunction in the entire world. 97% efficacy rate.

ReHealth

Booth #5071

ZT Centro Empresial Loc E1 y E2 Colonia Cancun, Quintana Roo 77500

Ph: (855) 560-HEAL

Email: info@rehealth.com www.rehealth.com

Rehealth is a global leader in regenerative medicine and longevity therapies, offering innovative cellular treatments to address chronic conditions and enhance overall well-being. Specializing in Mesenchymal Stem Cell (MSC) therapy and Natural Killer (NK) cell therapy, we provide cutting-edge solutions that aren’t widely available in traditional U.S. clinics. Our mission is to help patients heal, restore vitality, and improve their longevity through personalized, science-based care. At Rehealth, we combine expert medical treatment with the latest advancements in cellular therapies.

rekindlemed

Booth #8077

19266 Coastal Hwy. Unit 4-1184

Rehoboth Beach, Delaware 19971 US

Ph: (302) 313-1193

Email: info@rekindlemed.com www.rekindlemed.com

Rekindlemed is a digital technology and consulting firm transforming patient care with our innovative Patient Journey System. Our SaaS platform integrates Practice Management, CRM, and Patient Automation to drive practice growth and improve patient outcomes. We provide tailored consulting for Hormone, Weight Loss, Aesthetic, and Wellness practices, delivering personalized strategies for success. Our Partner Platform connects practices with leading pharmacy, supplement, lab, device, and training resources, enhancing both care quality and business performance.

Relax Far Infrared Saunas

Booth #9041

3509 N. High St. Columbus, Ohio 43214 US

Ph: (614) 302-8903

Email: reggie@relaxsaunas.com www.relaxsaunas.com/superior

Our portable Far Infrared Sauna uses the most advanced far infrared generating technology available. The Relax Sauna generates 95 to 99 percent pure far infrared that improves blood circulation, reduces inflammation and pain, and revitalize your body. No other sauna is easier to use. No other sauna is more effective than the Relax Sauna.

Resbiotic Nutrition

Booth #6105

1500 1st Ave. North Ste C120 Birmingham, Alabama 35203

Ph: (667) 295-7372

Email: info@resbiotic.com www.resbiotic.com

Resbiotic Nutrition restores health through sciencebacked wellness by developing science backed proprietary microbiome based supplements for restoration of several gut-x axes of the body such as lung health, digestive health, immune health, heart health, and energy. Our mission is to restore the gut and beyond with our prebiotics and probiotics for overall well being.

Researched Nutritionals

Booth #4013

PO Box 224

Los Olivos, California 93441

Ph: (805) 693-1802

Email: customerservice@ researchednutritionals.com www.researchednutritionals.com

Researched Nutritionals® is dedicated to creating professional-grade, research-based formulations that are designed to promote energy and vitality and are supported by ongoing clinical trials to demonstrate efficacy. With products formulated with multiple mechanisms of action and focused on key areas of health such as mitochondrial function, immune support, detoxification, and cytokine health, Researched Nutritionals® is a leader within the dietary supplement market. We’re committed to providing powerful solutions, working directly with healthcare practitioners for their most challenging patient needs

Revian

Booth #6067

615 Davis

Ph: (561) 843-9233

Email: akeish@revian.com www.revian.com

Revian has invented the #1 Doctor recommended, all-LED, at-home hair loss treatment for men & women. Our device is clinically proven to grow more hair in less time than other hair loss products.

RGCC North America

#3111

8354 Northfield Blvd. Ste 3700

Ph: (800) 813-1372

Email: info@rgcc-internatnional-northamerica. com

www.myrgcc.com and www.rgccinternational.com

RGCC is globally recognized as the leading laboratory in the field of personalized cancer testing. We believe in personalized treatment that considers the individuality of each patient and the unique expression of the cancer cells within each patient’s unique genetic makeup and physiology. RGCC partners with patients and practitioners throughout the cancer journey with powerful testing tools that provide actionable information allowing for the creation of personalized treatment protocols, paving the way for better outcomes.

Revelation Pharma

Booth #3085

9777 Pyramid Ct St 230

Englewood, Colorado 80112

Ph: (480) 326-4765

Email: info@revelationpharma.com www.revelationpharma.com

Revelation Pharma is a national network of 503A and 503B compounding pharmacies providing innovative and quality pharmacy preparations and services through “industry best” patient care and solutions for customers.

Riize Health

Booth #7114

2950 N Loop West

Ph: (888) RII-ZEUP

Email: support@riizehealth.com www.riizehealth.com

Riize LLC is revolutionizing the healthcare industry as a leading telemedicine service provider. Our specialized focus on men’s and women’s sexual health sets us apart from the competition. We are proud to offer convenient online healthcare service that connects individuals with licensed healthcare providers. Patients no longer have to endure long wait times or travel to a physical clinic. Quality healthcare is just a few clicks away. Experience the expertise that Riize offers. Your health and well-being are our priorities.

RP Therapies, LLC / PhalBack

Booth

#6055

667 Phillips Rd.

Saint Joseph, Louisiana 71366

Ph: (225) 603-0915

Email: Denise@rptherapies.com www.phalback.com

RP Therapies provides the PhalBack product to therapeutically increase the size of a penis - GIRTH and LENGTH. The process is noninvasive - no needles, filler, or surgery. Patients progress through a series of custom contouring penis chambers as they grow. PhalBack was developed to provide penile rehabilitation to men after prostate surgery, including buried penis. PhalBack is effective with any normal penis below 7.5’ PhalBack is used in the privacy of home.

Rupa Health

Booth #3021

177 Townsend St. San Francisco, California 94107

Ph: (954) 821-7917

Email: hello@rupahealth.com www.rupahealth.com/conferences

Rupa Health, the best way to order functional and integrative tests from 30+ lab companies. Effortlessly scale your practice -- order, track, and get results from 2,000+ tests in one place. We provide patient support so you can streamline your ordering altogether with no pre-existing lab accounts. Rupa is FREE for practitioners! Sign up to receive a special conference first order coupon only at: www.rupahealth.com/conferences

Rx Harmony (The JOI Group)

Booth

#8078

45 Technology Parkway S. Ste 150

Peachtree Corners, Georgia 30092

Ph: (770) 838-3570

Email: info@thejoigroup.com www.thejoigroup.com

Rx Harmony by The JOI Group specializes in innovative, turn-key medical programs that enhance patient care and support practice growth. Our comprehensive solutions include advanced treatments for weight loss, men’s and women’s health, sexual wellness, hair restoration, and allergy management. We empower healthcare providers with the tools and resources needed to deliver exceptional outcomes, improve patient satisfaction, and boost practice revenue.

Scientific Age Management

Chamber Inc.

Scientific Age Management, LLC.

Ph: (561) 556-3322

Email: hello@saltchamberinc.com www.saltchamberinc.com

SALT Chamber was started in 2012 by Founder and CEO Leo Tonkin and has become the leading authority on designing, building, and developing salt therapy concepts for day spas, med spas, wellness centers, and health practitioners to add salt therapy to their existing menu of services. SALT Chamber provides full turnkey solutions for owners and developers, as well as architects, interior designers, and general contractors from design and consultation, through to installation, operations, and training.

Ph: (310) 994-1744

Email: sales@scientificagemanagment.com

www.scientificagemanagement.com

Scientific Age Management is a personalized Asset Management company in the Longevity and Biohacking spaces. We provide sales, installation and training for the top Hyperbaric Oxygen Therapy chambers from Telomere.one, HPOTech and HBOT4Life for both medical and wellness clinics as well as home installations and use. We also represent the state-of-the art Multi-Frequency Light Beds from ARRC LED. Our firm is committed to your success and our team has over 30 years of combined experience in the Hyperbarics industry.

#6032

Ph: (843) 513-8306

Email: info.us@seca.com www.seca.com/554

seca, a global leader in healthcare medical technology with over 180 years of expertise, excels in measuring systems, body composition analysis, and vital monitors. Our medical Body Composition Analyzer (mBCA) provides precise health baselines by assessing fat mass, visceral adipose tissue, skeletal muscle mass, body water, and more. These insights are crucial for tailored therapies in longevity medicine, enhancing muscle mass, cellular health, and maintaining youthful energy levels. Discover seca’s innovations at A4M LongevityFest 2024.

SelfDecode

Booth #4100

13727 SW 152nd Street Ste 896

Miami, Florida 33177

Ph: (949) 328-4072

Email: support@selfdecode.com www.selfdecode.com

SelfDecode is an innovative company dedicated to revolutionizing personalized health and wellness. We offer the world’s most advanced AI-powered DNA testing and analysis. Our health app combines genetic information, lab test results, lifestyle factors, symptoms, conditions and health goals to provide personalized diet, supplement and lifestyle recommendations to optimize your health. Our mission is to empower individuals to take charge of their well-being through cutting-edge technology and comprehensive data analysis.

Selphyl PRFM

Booth #2049

2436 Emrick Blvd. bethlehem, Pennsylvania 18020

Ph: (877) 735-7495

Email: info@selphyl.com www.selphyl.com

The SELPHYL® System is designed for the safe and rapid preparation of Platelet-rich Fibrin Matrix (PRFM) from a small sample of blood at the patient point of care. SELPHYL® removes virtually all contaminating cells and is independent of operator technique. PRP is converted to PRFM through a controlled process, creating a scaffold that serves to protect and preserve platelets. Think of SELPHYL® as the next generation PRP.

SENSIQ Nootropics & Adaptogens

Booth

#6115

225 Engle St.

Tenafly, New Jersey 07670

Ph: (786) 713-1470

Email: hello@sensiqnootropics.com www.sensiqnootropics.com

At SensIQ, our mission is to enhance cognitive wellness and support the brain’s natural ability to perform at its best. Our vision is to provide safe and effective nootropic and adaptogen supplements that help people improve their focus, memory, and stress management abilities. Our products are backed by science and formulated to provide optimal results.

SFI Health

Booth #8100

795 Trademark Dr. Reno, Nevada 89521

Ph: (775) 850-8800

Email: CustomerServiceUsa@sfihealth.com www.us.sfihealth.com

SFI Health is a global leader in developing premium integrative health solutions for the microbiome and cognition and is home to Klaire Labs. For over 50 years, Klaire Labs has been known for its professional-grade, hypoallergenic nutritional supplements, and the leading probiotic line, TherBiotic®, trusted by healthcare professionals and their patients for their purity, potency & performance.

Share One

Booth #8044

200 University Blvd Ste 225 Round Rock, Texas 78665

Ph: (512) 846-6386

Email: info@share.one

www.share.one

Share One specializes in creating high-quality video testimonials for businesses, helping them build trust and credibility with their audience. We handle every step of the process—from inviting clients and conducting interviews to editing and delivering the final product. Our services allow businesses to showcase authentic client experiences on their websites and social media effortlessly, with minimal time investment.

Silver Biotics

Booth #3044

705 E 50S

Ph: (801) 756-1000

Email: info@ablsilver.com

www.silverbiotics.com

We have taken the old technology of colloidal silver and improved it to create the next generation of silver products. SilverSol® was created to improve on current formulas to make them safer and more effective. Through a new manufacturing technology, patented under multiple patents, and patents pending, our advanced nano- silver solution has become the new standard by which all other silver products are measured. We call this new generation of colloidal silver, SilverSol.

SilverCeuticals Inc.

Booth #7070

1396 W. 200 South, Ste 2C

Lindon, Utah 84042

Ph: (385) 212-4044

Email: sales@silverceuticals.com www.silverceuticals.com

SilverCeuticals harnesses cutting-edge nano-silver technology to develop a range of products including immune supports, beautifying cosmetics, oral care, and wound care technologies. Our advanced formulations are designed to address the specific needs of anti-aging professionals and their patients, promoting wellness and rejuvenation. With a commitment to global well-being, we strive to alleviate suffering by delivering innovative solutions that enhance health and vitality. Discover the power of SilverCeuticals to transform aging gracefully.

Sinclair

Booth #3109

1239 Broadway 1103 New York, New York 10001

Ph: (888) 415-1192

Email: marketing.usa@sinclair.com www.sinclair.com/us/

Sinclair is an international company operating in the fast growth, global aesthetics market. Sinclair has built a strong portfolio of differentiated, complementary aesthetics technologies, which are experiencing significant growth, targeting unmet clinical needs for effective, high quality, longer duration, natural looking & minimally-invasive treatments. Sinclair is planning entry to multiple new geographic markets & line extension launches over the next few years.

SiPhox Health

Booth #1101

111 Terrace hall Ave.

Burlington, Massachusetts 01803

Ph: (781) 202-5192

Email: enterprise@siphoxhealth.com www.siphoxhealth.com

SiPhox Health offers comprehensive private label at-home blood test kits, from inflammation to hormones, metabolic health to cardiovascular, and more. The software allows our partners to add automatic health recommendations to reports, drop ship test kits to patients, and track them in transit to the patient and back to the lab.

SkinGenuity, LLC

Ph: (727) 239-0005

Email: jackiew@skingenuity.com www.skingenuity.com

SkinGenuity, LLC has developed a new form of targeted regenerative medicine for aesthetics that can treat specific tissue types and conditions. We manufacture innovative products for skin, hair restoration, eyelash growth, vaginal health and other disorders. Our Inter-Cell Messenger Technology™ incorporates two Nobel-Prize winning discoveries, bioengineered human growth factors and DNA repair enzymes. The extensive clinical studies conducted and published in leading journals demonstrates the clear benefits of using targeted growth factors for specific conditions with optimal patient safety.

Ph: (661) 222-2242

Email: Welcome@Mysmilebody.com www.mysmilebody.com

Your mouth is the gateway to your overall wellbeing. At Smilebody we understand this. That’s why all of our treatments take into consideration your whole body, starting with your smile! We combine dental and medical to optimize your health.

SNiP Nutrigenomics

Booth #3039

901 Sam Rayburn Hwy. Melissa, Texas 75454 US

Ph: (469) 437-7344

Email: info@snipnutrition.com www.snipnutrition.com

SNiP Nutrigenomics specializes in DNA-personalized nutritional supplementation, targeting twenty-two key genetic vulnerabilities to maximize mind-body wellness. SNiP’s simple, innovative, all-in-one CODE Complex is individually formulated to address ten essential health areas, including heart, gut/microbiome, methylation, inflammatory, and cognitive health. The process includes a home DNA test, personalized health reports, and monthly supplementation via auto-delivery. With a focus on privacy, purity, and safety, SNiP offers a revolutionary, affordable, and science-driven approach to filling nutritional gaps for foundational, whole-body health optimization.

SomAlive Technologies

Booth

#9117

489 Agnes Ste 112-#423 Bastrop, Texas 78602

Ph: (702) 337-3603

Email: Support@SomAliveTechnologies.com www.somalive.com

SomAlive Technologies provides the most advanced and luxurious somatic sound therapy devices and methodology to support deep relaxation, healing, and transformation of the nervous system. Our flagship product, the Z.5 Experience is a testament to our unwavering commitment to outstanding quality and service.

SottoPelle

Booth

#2072

8412 E. Shea Blvd. Ste 101 Scottsdale, Arizona 85260

Ph: (480) 874-1515

Email: response@sphrt.com www.sottopelletherapy.com

SottoPelle® is a renowned international training company dedicated to improving the quality of life during all phases of aging for men and women with pellet therapy. The late, Dr. Gino Tutera MD, FACOG, Founder of SottoPelle®, was the premier doctor pioneering bio-identical hormonal therapy science with preventing and mitigating many diseases and conditions. Our Services goes beyond simply providing physicians with training. We develop long-term relationships built on trust, strive to be knowledgeable and compassionate.

Standard Process Inc.

Booth #5098

1200 W. Royal Lee Drive Palmyra, Wisconsin 53156

Ph: (800) 558-8740

Email: info@standardprocess.com

www.standardprocess.com

Since 1929, Standard Process® has been a visionary leader in whole food nutrient solutions. The company creates quality nutritional supplements based on the whole food philosophy of its founder, Dr. Royal Lee. Headquartered in Palmyra, Wisconsin, Standard Process offers nutritional supplements, Veterinary Formulas™, and is the exclusive U.S. Distributor of MediHerb® herbal supplements.

Stemregen

Strive Pharmacy

Ph: (770) 762-5399

Email: kensy@stemregen.co www.stemregen.co

STEMREGEN focuses on the body’s innate repair system as the groundbreaking approach to healthspan. With unwavering commitment to research, we source the most powerful ingredients found in nature to create the most scientifically advanced stem cell solutions for optimal health and longevity.

Ph: (480) 626-4366

Email: sales@strivepharmacy.com www.strivepharmacy.com

In a realm dominated by pharmaceutical giants, we stand apart. A compounding pharmacy striving for the personal side of healthcare. With that comes substantially greater scrutiny than “Big Pharma.” This scrutiny, which would otherwise weaken us, has become our superpower - and your evidence of superior quality. Scrutiny for us isn’t a barrier, it’s a benchmark of excellence. We don’t just offer better medication, but a promise of safety, efficacy, and trust - a promise that others can’t keep.

Summus Medical Laser

Booth #8123

1185 West Main Street Franklin, Tennessee 37064 US

Ph: (615) 595-7749

Email: info@summuslaser.com www.summuslaser.com

Summus Medical Laser is a renowned leader in the laser therapy industry, providing laser products to over 51 countries that have resulted in millions of treatments performed worldwide. With a strong commitment to continued innovation, reliable stateside customer service, and growing brand awareness, Summus Medical Laser is devoted to empowering healthcare professionals to provide optimal patient care through the use of advanced laser therapy. To learn more, visit https://www.summuslaser.com.

In seconds. On demand.

Sunlighten

Booth

#3070

7373 W. 107th Street

Overland Park, Kansas 66212

Ph: (800) 352-4140

Email: businessdevelopment@sunlighten.com www.sunlighten.com

Shining light on infrared technology, Sunlighten® is the industry leader in personalized infrared light treatment. Since 1999, Sunlighten has innovated wellness products that empowered its customers to improve their quality of life. Its patented heater technology rejuvenates the body by delivering the highest dose of infrared energy at a cellular level. Sunlighten has built a global community of businesses, consumers, and trusted experts to support each other and bring light, hope, and happiness to people all over the world.

Swish30 / Doctors Nano

Booth #4104

6130 W Flamingo RD Ste 865 Las Vegas, Nevada 89103

Ph: (888) 321-1235

Email: info@doctorsnano.com www.doctorsnano.com

Glutathione Next Era’ in seconds, on demand. Swish30® and PrimaSkin® feature HydraStat® nano-delivery. This patent-pending technology crafts ultra-pure water for water-cluster protection of nano particles. This increases bioavailability and transference into the organic cell, producing exceptional outcomes. Doctors Nano LLC advisors champion these revolutionary health and beauty advances with professional retail distribution and total support for wellness, performance and longevity clinics. Registered trademarks held by Biotech Nutritional Sciences, LLC.

TA Sciences

Booth #5005

7975 N Hayden Rd Ste C-101

Scottsdale, Arizona 85258

Ph: (212) 588-8805

Email: info@tasciences.com www.tasciences.com

T.A. Sciences® was founded in New York City by Noel Thomas Patton in 2002. T.A. Sciences® is dedicated to creating research-based, clinically tested products that help address telomere shortening through Telomerase Activation. T.A. Sciences® is widely recognized as the leader in the field of Telomere Biology. T.A. Sciences® spends over $1 million each year on leading edge scientific research, including having published doubleblind, placebo-controlled studies proving the safety and effectiveness of its premiere product TA-65®.

Tailor Made Compounding

TANITA Corporation of America

TAXANISTA

Booth #6099

4904 S POWER ROAD Ste 103-115 Mesa, Arizona 85212 US

Ph: (859) 887-0013

Email: support@tailormadecompounding.com www.tailormadecompounding.com

The Tailor Made Difference , a Higher Standard of Care TMC provides the highest quality compounded solutions while leading the industry in compliance, safety, provider education, and customer service, thereby empowering healthcare providers the ability to optimize the health of their patients. Visit us at www.tailormadecompounding.com to learn more about our integrative care treatments!

Ph: (847) 212-7042

Email: jhan@tanita.com www.tanita.com

TANITA is a global leader in health monitoring and body composition analysis, pioneering the development of BIA technology. TANITA’s professional and consumer products provide detailed body composition data, including weight, body fat percentage, muscle mass, and more. Trusted by medical professionals and researchers worldwide, TANITA’s products are FDA-cleared, ensuring the highest accuracy and reliability. Committed to advancing health technology, TANITA continually invests in research and development, setting the standard for quality and precision in health monitoring devices.

Ph: (480) 331-3316

Email: info@Taxanista.com www.taxanista.com

Taxanista, a full service CPA Accounting, Tax Strategy and Consultancy firm. We specialize in setting up functional & integrated systems throughout your small to established practice. We are ProActive not ReActive. We provide You with ideas and solutions, not only on structure, systems, & tax strategy, but most importantly, we explain and provide you with Actionable Data with which to make informed decisions. Staff licenses include - CPA, Master’s Taxation, IRS Enrolled Agent, CMA, US Tax Court Practitioner* highest level.

Terra Biological, LLC

Booth #8081

3830 Valley Centre Dr Ste 705 PMB 561 San Diego, California 92130

Ph: (858) 947-5722

Email: acash@TerraBiological.com www.oxaloacetatecfs.com

Since 2006 Terra Biological has lead the way in Calorie Restriction Mimetics with the patented metabolite Oxaloacetate (OAA). Our initial product, “benaGene”, is used by thousands of patients worldwide for anti-aging, reduction of brain fog, and improvement in athletic performance. Following two clinical trials, our “Jubilance” product was shown to significantly relieve anger, stress, sadness, and irritability in women with Premenstrual Syndrome (PMS). Clinical trials with “Oxaloacetate CFS” have shown significant improvements in fatigue in ME/CFS and Long COVID patients.

Texas Star Pharmacy

Booth #8009

3033 W Parker Rd Ste 100 Plano, Texas 75023

Ph: (972) 519-8475

Email: providersupport@texasstarpharmacy. com www.texasstarpharmacy.com

Texas Star Pharmacy is built on one philosophy; that our patients’ health and well-being are our primary focus. We treat our patients as part of our family. We are committed to delivering the best quality solutions for our patients’ health at the best possible cost. We ensure the best solutions through our compound pharmacy, granting us the ability to make new medications suited for your needs.

Thaena Inc.

Booth #8093

5951 E 18th St. Ste 110

Vancouver, Washington 98661

Ph: (503) 506-8732

Email: info@thaena.com www.thaena.com

Thaena®, pronounced | thay-nah |, is a femalefounded, Pacific Northwest-based company and the proud creators of ThaenaBiotic®, the world’s first stool-derived complex postbiotic supplement. Our mission is simple: To use science, radical innovation, and the microbiome to help people feel better. We believe in using the innate wisdom of the human body to shift the paradigms of medicine by expanding access to microbiome supports and putting postbiotics on the map.

#

The Liver Clinic

Ph: (949) 275-6110

Thera Wellness Solutions LLC

Booth #1099

10411 Motor City Drive Ste 615

Ph: (443) 834-4682

Therasage

Booth #8055

9736 Via Emilie

Ph: (561) 756-0135

Email: mimi@equilibriumlabs.com www.loveyourliver.com

Did you know that 38% of the U.S. population has fatty liver? The Liver Clinic will be on-site offering non-invasive FibroScan assessments to evaluate liver fat and fibrosis (scarring). Receive immediate results with Chief Medical Officer Dr. Gareth MorrisStiff, who will also introduce solutions like the deliver-ance elixir. We are offering a special reduced price of $249 (normally $500). Pre-book your slot. Length: 20 minutes. Preparation: No food/coffee for 3 hours. Water is ok. Clothing - wear two pieces.

Email: office@therawellness.us www.therawellness.us

We’re a passionate group of people driven by a single purpose: Empowering you to unlock the body’s innate healing potential through biofield technology. Our team brings together diverse expertise and perspectives to deliver cutting-edge alternative therapies & support to practitioners. We are dedicated to providing personalized and compassionate care, tailoring our approach to your practice’s needs.

Email: support@therasage.com www.therasage.com

World’s premiere infrared healing products. Therasage has been helping and healing people with holistic products for over 20 years. Harnessing the power of the sun and the healing benefits of Earth’s natural frequencies, Therasage has been able to aid people in their journey to happiness and longevity. We are constantly innovating products to improve the lives of others.

Most Innovative Probiotic #1

Conquering chronic struggles & beyond

Clinically trialed

Physician formulated Exclusive probiotic & prebiotic formulas

resB® Lung Support Probiotic

“My coughing has greatly reduced!*”

I have had asthma my entire adult life. I am unable to take inhaled steroids, which is the standard treatment

protocol, because I have rare, severe side e ects. After a few days of taking resB, I noticed breathing felt easier. A few months in, my coughing has greatly reduced. I feel younger and more alive.

— Sandy F, Brooklyn, New York

AVAILABLE

Beneﬁts

Respiratory support*

May clear mucus & minimize coughing*

Seasonal sinus & bronchial support*

Improves digestion, gut, & immune health*

Better sleep due to better breathing*

Exclusive Formula

Respiratory Probiotic Blend (RSB11®, RSB12® & RSB13®)

Herbal Blend (Turmeric, Holy Basil & Vasaka)

72%

participants with chronic lung conditions reported lung function improvement*

82%

participants with chronic lung conditions reported quality of life improvement*

95%

participants likely to recommend resB® to others*

Theriome

The Science of You

Theriome

Booth

#7100

850 N 5th Ave.

Phoenix, Arizona 85004

Ph: (844) 844-2768

Email: info@therio.me www.therio.me

We equip providers with metabolic and microbiome tests, with the deepest resolution and coverage available to date, that allow for early recognition of issues and automatically generate customized protocols for the patient. We do not sell any supplements or interventions and focus on equipping the physician with knowledge about their patient’s biology.

Timeline

Booth #8033

824 U.S. Highway 1 Ste 320 N.Palm Bch, Florida 33408

Ph: (888) 631-3359

Email: care@timeline.com www.timeline.com

Timeline (parent company Amazentis) is a pioneering Swiss health science company committed to revolutionizing the longevity industry with its groundbreaking, clinically proven ingredient Mitopure®. This proprietary component enhances cellular health in advanced supplements and skincare. With over a decade of expertise in aging science, Timeline aims to extend healthspan. The company is backed by 15+ years of research by distinguished scientists, numerous clinical studies, and over 50 global patents. Investors include Nestlé Health Science and L’ORÉAL. Discover more at www.timeline.com

Tiny Health

Booth #7117

6104 Old Fredericksburg Rd. Ste 91622

Austin, Texas 78749

Ph: (646) 436-0699

Email: cheryl@tinyhealth.com

www.tinyhealth.com

Tiny Health is the first-ever at-home baby gut health testing company that helps families detect gut imbalances in the critical first 1,000 days and take action to avert long-term chronic health conditions. 1 in 2 children today have at least one chronic condition like eczema, allergies, asthma, metabolic disease, ADHD, etc. Early life gut imbalances are at the root cause of this rapidly rising pediatric epidemic because 80% of our immune system lies in the gut.

Topi Click | Team Technologies

Booth #2098

300 Parkebrook Place Ste 210 Woodstock,

Ph: (877) 870-8448

Email: info.TopiCLICK@teamtech.com www.topi-click.com

Topi-CLICK® by TEAM Technologies manufactures topical metered-dosing applicators that are accurate, innovative and easy-to-use; which is the focus of every product design including the Topi-CLICK Micro® and the Perl® Vaginal Dosing Method. Visit booth #2098 for your FREE sample kit or request one at https://topi-click.com/samples. We’ll also provide copies of the ARL Bio Pharma study proving Topi-CLICK® 35 is the most accurate topical dosing dispenser among those tested. Visit https://topiclick.com for product and ordering information.

TouchMD

Booth #3066

Trocar Supplies Booth #9039

Ph: (813) 796-6451

Email: hello@touchmd.com www.touchmd.com

TouchMD’s med spa software simplifies client communication, demonstrates your expertise, and showcases your results to exceed client expectations. Our state-of-the-art photography tool showcases your client’s transformation with beautiful, consistent imagery every time. Integrated client education and communication functionality make it the ultimate consultation tool. Visit www.touchmd.com to learn more.

Ph: (740) 314-9959

Email: brandon@trocarsupplies.com www.trocarsupplies.com

Trocar Supplies, a family-owned business, is the pioneer and worldwide standard for the disposable trocar medical kit industry. We take great pride in offering an affordable price for the highest quality products. Through patient feedback and researchbased treatment, our trocar kits have been the optimal way to treat hormone deficiencies for over fifteen years. The utilization of our disposable trocar kits are the most efficient method and safest product for hormonal replacement therapy.

Troscriptions

Booth #2036

8 The Green #16151

Dover, Delaware 19901

Ph: (517) 793-4315

Email: buccalup@troscriptions.com www.troscriptions.com

Physician-formulated, pharmaceutical-grade, precision-dosed health optimization formulations delivered through a buccal troche. Troscriptions provides “cheat codes” (i.e., troches) that improve mitochondrial health and brain function, relieve stress and tension, help you sleep, decrease pain, and more. Dynamic equanimity is just a troche away.

TruDiagnostic

Booth #8060

881 Corporate Drive

Lexington, Kentucky 40503

Ph: (859) 797-2983

Email: support@trudiagnostic.com www.trudiagnostic.com

TruDiagnostic is a leading health data company with a focus on multi-omics and insights gained from the fluid epigenome. Established in early 2020, after development and build out of its 10,000 square ft state of the art laboratory with Illumina equipment and consultation it launched its first physician and patient test “TruAge”. Today, TruDiagnostic has built a premiere epigenetic database of DNA Methylation markers and covariates which is one of the largest in the world.

TrueBinding

Booth #4005

300 Lincoln Centre Drive Ste 200 Foster city, California 94404

Ph: (650) 847-1117

Email: info@truebinding.com www.truebinding.com

TrueBinding Inc. is a clinical stage biotherapeutic company creating new and exciting molecules for applications in neurodegenerative and metabolic diseases, stroke, oncology and other areas with great unmet medical need.

Ulta Lab Tests

9237 E.

Ph: (480) 681-4081

Email: contactus@ultalabtests.com www.ultalabtests.com

Ulta Lab Tests provides healthcare professionals and their patients with substantial discounts on laboratory testing services, thanks to the cumulative buying power of thousands in our network. This leverage allows us to offer exceptionally low prices, which we pass directly to our partners and their patients. Additionally, healthcare professionals can manage their practices more efficiently with our complimentary practice management solution. Patients and clients can conveniently order tests 24/7 through a personalized microsite, provided free of charge by Ulta LabTests.

Ph: (385) 488-5175

Email: sales@ultraluxhealth.com

www.ultraluxhealth.com

Powerful health solutions for modern problems We provide scientifically supported, cutting-edge solutions that allow you to protect, maintain, or improve your health. With UltraLux Health, your health can always be one step ahead. UltraLux Health was founded on this principle: modern health threats require modern solutions. While these attacks have progressed, the common practices—multivitamins, supplements, and a proper diet, haven’t. That’s why our mission is to find and provide modern health solutions to counteract modern threats.

University Compounding Pharmacy

Booth #2013

1875 3rd Ave. San Diego, California 92101 US

Ph: (800) 985-8065

Email: info@ucprx.com www.ucprx.com

UNIVERSITY COMPOUNDING PHARMACY (UCP) a nationally recognized leader in drug and device therapies. For 27 years our expert Pharmacists and experienced Physician Liaison team have been dedicated to support an unbiased product line, devising the management of BHRT conditions for your patients. We meet FDA & BOP prescription requirements and dispense in nearly 50 states. COMPOUNDED: THYROIDS, ESTROGENS, PDE-5 INHIBITORS- BIOIDENTICAL HORMONES.

US Biotek Laboratories

Booth #5039

16020 Linden Ave. N. Shoreline, Washington 98133

Ph: (206) 365-1256

Email: info@usbiotek.com www.usbiotek.com

US BioTek Laboratories is an industry-leading international laboratory that pioneers testing methods to deliver a wide variety of comprehensive full body panels supporting a complete picture of wellness. Our rigorous VeriTek™ process and emphasis on automation consistently deliver the accurate, repeatable results you expect and your patients deserve.

Vale Medical LLC

Booth #8021

7231 S. 900 East Ste 200 Midvale, Utah 84047

Ph: (561) 379-6230

Email: carmine@valemedical.com www.valemedical.com

Vale Medical is a leader in innovative regenerative medicine technology, proudly serving as the premier U.S. provider of STORZ Medical shockwave devices. Our product range includes the D-ACTOR® 100 radial pressure wave, DUOLITH® SD1 T-TOP Focus Shockwave, and Magnetolith (EMTT®). These stateof-the-art, non-invasive Swiss technologies empower clinicians to effectively treat diverse conditions, improve patient outcomes, and accelerate the healing process. Come visit our booth for a live demo!

Vertisis Custom Pharmacy

Booth #9047

9343 E. Bahia Drive Ste 200 Scottsdale, Arizona 85260

Ph: (303) 476-3447

Email: matthewb@vertisis.com www.vertisis.com

Vertisis is one of the most unique sterile-injectable compounding pharmacies in the United States. Our focus is on going “above and beyond” traditional compounding pharmacies by raising the standards of 503A compounding pharmacies to include exceptional products, unique delivery, advanced education, and an amazing relationship with health care providers with a seamless delivery of care. We are Vertisis Custom Pharmacy, your custom compounding pharmacy for integrative and naturopathic IV therapies and compounds.

Vibrant Practice

Booth #1093

111 Janes Street City

Mill Valley, California 94941

Ph: (630) 248-9366

Email: sunita@vibrantpractice.com www.vibrantpractice.com

VIBRANT is the all-in-one business and technology platform for personalized-medicine practices. We are building AI superpowers for clinicians. Think of us as your Tony Stark suit. Vibrant leverages AI and proprietary tools like our clinical co-pilot and patient app to automate manual processes, remove communication barriers, and craft the unique, personalized experience that modern-day patients expect. We help you create a sustainable business model, so you can focus on delivering high-quality, personalized care to more patients.

Vibrant Wellness Booth #7033

3521 Leonard Ct Santa Clara, California 95054 US

Ph: (866) 364-0963

Email: hello@vibrant-wellness.com www.vibrant-wellness.com

Vibrant Wellness is a leading CAP-accredited and CLIA-certified biotech company based in Santa Clara, CA. We deliver life-transforming lab testing that enables health and wellness providers to discover the root of patient health issues. We’re at the forefront of modern medicine and research, providing personalized health analytics using cutting-edge, high-quality technology. We believe that anyone can achieve better health and vibrant longevity through individualized solutions based on testing—not guessing.

VIBRAPLATE

Booth #2060

11214 E. MLK Blvd. Ste 210 Seffner, Florida 33584 US

Ph: (813) 498-9556

Email: A.ochsenterprises@gmail.com www.healthisfreedom.com

Vibraplate offers innovative vibration therapy equipment designed to enhance fitness, wellness, and rehabilitation. Using whole-body vibration technology, Vibraplate machines improve muscle strength, flexibility, and circulation, providing an effective solution for weight loss, pain relief, and injury recovery. Ideal for both personal and professional use, Vibraplate combines sciencebacked performance with user-friendly designs to help individuals achieve their health and fitness goals efficiently. Experience the benefits of vibration training with Vibraplate’s cutting-edge solutions.

Vida Lifescience

Booth

#9029

16691 Noyes Ave.

Irvine, California 92606

Ph: (949) 385-7372

Email: sales@vidalifescience.com www.vidalifescience.com

Vida Lifescience, the exclusive U.S. distributor of Aurora Nutrascience, delivers advanced liposomalbased supplements focused on bioavailability and efficacy. Aurora Nutrascience’s cutting-edge technology enhances nutrient absorption, providing high-quality, non-GMO, gluten-free, and sugar-free products. Manufactured in a GMP-certified facility, all products undergo third-party testing for purity and potency. Vida Lifescience offers a comprehensive product range, from immune support to wellness solutions, making them a trusted leader in innovative, science-backed health and wellness supplements.

Viewmind, Inc.

Booth #5104

PO Box 1155

Alpine, New Jersey 07620

Ph: (732) 642-9797

Email: info@viewmind.com www.viewmind.com

ViewMind is the global leader in precision measurement of ocular movement alterations, a window into brain health. ViewMind Atlas™ utilizes this non-invasive approach to assess brain health by measuring ocular movement alterations. This has the potential to achieve: High-precision assessments for improved patient care decisions and Scalable and affordable solutions for wider healthcare implementation.

Vita Aid Professional Therapeutics

Booth #7049

#302-20285 Stewart Crescent Unit 303

Maple Ridge, British Columbia V2X 8G1

Ph: (604) 465-1688

Email: info@vitaaid.com www.vitaaid.com

With 20+ years of experience in the natural health industry, Vita Aid Professional Therapeutics strives to provide high-quality and effective nutraceuticals for health care practitioners worldwide. We focus on products for professional, safe, and effective therapeutic use and follow strict pharmaceuticalgrade standards. What differentiate Vita Aid from others are: • Exclusive to health care practitioners • Clinical evidence based formulations • No added stearic lubricants – for higher bioavailability of active ingredients • Vegetarian formulas

Stream Inc

Booth #2115

P.O Box 58609

Renton, Washington 98058

Ph: (888) 472-7771

Email: customerservice@vita-stream.com www.vita-stream.com

Vita Stream was founded over a decade ago with the goal of providing the highest quality supplements and health products to help you achieve vibrant health, beauty, and happiness. Our premium dietary supplements the peptide bioregulators, based on Dr. Khavinson’s groundbreaking formula, are made in the USA to naturally regulate and enhance bodily functions. Choose Vita Stream for scientifically backed, high-quality supplements that support optimal health and well-being.

Ph: (936) 645-8194

Email: support@vitaboom.com www.vitaboom.com

Vitaboom is all about quality and convenience. We collaborate with trusted suppliers who source premium, scientifically-backed ingredients. Our userfriendly online interface empowers you to explore a diverse range of supplements and choose or craft tailored stacks effortlessly. Whether you seek an energy boost, immune support, enhanced focus, or overall well-being, we have the perfect blend of supplements to cater to your unique health goals.

VO2 Master

Ph: (833) 862-6787

Email: info@vo2master.com www.vo2master.com

The VO2 Master portable metabolic analyzer allows wellness and fitness facilities to provide their clients with VO2 Max testing, what many experts consider the best predictor for longevity. Metabolic testing can increase revenue per square foot by testing on already existing treadmills and bikes and providing clients valuable personalized data.

Vita

VSL#3 / Actial Nutrition

Booth #7112

400 W. South Boulder Rd. Ste 2500 Lafayette, Colorado 80026

Ph: (732) 551-0787

Email: s.androcy@vsl3usa.com www.vsl3.com

VSL#3 is the #1 gastroenterologist-recommended multi-strain probiotics brand. It is a medical food probiotic known for its high CFU count, diverse mix of complementary bacteria strains, and robust history of clinical research. VSL#3 is available at all retail pharmacies, online at www.vsl3.com, on amazon. com and available on the Fullscript platform.

Vydence Medical

Booth #1043

8411 Laurel Fair Circle Ste 100 Tampa, Florida 33610

Ph: (574) 354-1347

Email: ctinos@vydence.com www.lasers.vydence.com

Development, manufacturing and distribution of medical devices for aesthetic markets in dermatology, plastic surgery, phlebology, and other specialties;

Wavi Medical

Booth

#1066

3857 Steele Street Ste 1293 Denver, Colorado 80205

Ph: (713) 823-1943

Email: support@wavimed.com www.wavimed.com

The all-in-one WAVi Scan EEG system features FDA-cleared and patented hardware and software, offering objective measures of cognition to aid in clinical diagnosis. WAVi’s goal is to “Help the World Think Better” by empowering clinicians to make more informed diagnoses regarding brain health and performance.

WAVwatch

Booth #8122

10119 Cherry Lane

Lexena, Kansas 66220

Ph: (423) 618-8441

Email: john@wavwatch.com www.wavwatch.com

The all-new WAVwatch 2.0 is the next evolution in sound frequency wellness wearables. Now smaller, waterproof, and featuring customized frequency playlists, it’s designed to support your body’s natural balance. More than just a watch, WAVwatch 2.0 is your personalized tool for promoting holistic well-being. Harness the natural power of sound frequencies to encourage relaxation, stress management, and general health support. WAVwatch 2.0 empowers you to take charge of your self-care, anytime, anywhere.

Weber Laser Systems Booth #9104

1926 Bonus Drive San Diego, California 92110

Ph: (619) 508-3952

Email: info@weberlaser.com www.weberlaser.com

Weber Laser Systems - Weber Medical. A Beacon of Innovation in Medical Laser therapies. Weber laser systems educates and provides state of the art, revolutionary technology utilizing low level laser therapy to improve health globally while leading the next generation of wellness movements. Innovations in medical laser therapy and extending its legacy of transformation in healthcare.

WebToMed

Booth #9021

1515 S. Grove Ave #3637

Barrington, Illinois 60011

Ph: (866) 999-8550

Email: info@webtomed.com www.webtomed.com

WebToMed provides digital marketing and e-commerce solutions to help your healthcare business increase online presence, engage a wider audience, and grow revenues. Visit our booth to learn more.

Wellne ss Clinic arketing

Acquiring Patients, Made Easy

Wellness Clinic Marketing

Booth #4060

1470 Biscayne Blvd

Miami, Florida 33132

Ph: (800) 401-7046

Email: info@wellnessclinicmarketing.com www.wellnessclinicmarketing.com

Providing marketing services to medical wellness practices, which offer cash-based medical treatments to men and women looking to improve their health, restore maximum hormone levels, and improve their overall well-being. Over the past ten years, we’ve found that digital advertising has been the single most effective medium for a medical wellness practice to generate new patients. Combined with our proprietary PatientFlow Acceleration Program, we created a proven marketing system to generate high-quality leads and cash-paying patients for our medical clients.

WETHRIVV LLC

Booth #6061

3805 Old Easton Road #305 Doylestown, Pennsylvania 18902

Ph: (215) 582-8200

Email: hello@wethrivv.com www.wethrivv.com

WETHRIVV LLC offers innovative beauty solutions with REVIVV (revivv.co) for hair growth and Mask_d (maskad.co) for skincare. REVIVV includes Hair Growth Serums, a Scalp Roller, Massager, and Detox Shampoo. Mask_d features the Peptide Bomb with 14 peptides and 3 growth factors, a Hydrating Serum, Derma Roller, and Infusion Mask for rejuvenation and post-procedure care.

Wellness Pharmacy

Booth #1036

3401 Independence Dr. Ste 231 Birmingham, Alabama 35209

Ph: (800) 227-2627

Email: info@wellnesspharmacy.com www.wellnesspharmacy.com

With over 60 years of compounding experience, Wellness Pharmacy is considered the industry leader in quality and customer service. Our specialties include chelation, bioidentical hormones, autism support, and preservative-free injectables. Wellness Pharmacy is also the only pharmacy to successfully patent the preparation of injectable glutathione. PCAB-accredited.

Wells Pharmacy Network

Booth #4046

3420 Fairlane Farms Rd. Ste 300

Wellington, Florida 33414

Ph: (800) 622-4510

Email: info@wellsrx.com www.wellsrx.com

Wells Pharmacy Network, a privately held 503A and 503B compounding pharmacy, specializes in wellness, anti-aging, weight management, sexual wellness, aesthetic dermatology, thyroid, and adrenal health. Committed to Quality, Service, and Safety, our mission since 2011, is to elevate compounding industry standards by merging superior science with high-quality compounded products. Patient safety is our top priority, and our daily commitment to the quality of compounded preparations reflects our dedication to excellence in healthcare.

Woodbridge Pharmacy

Booth #7037

4950 Barranca Pkwy Ste 102 Irvine, California 92604 US

Ph: (949) 857-2141

Email: prshealthgroup2@gmail.com www.woodbridgerx.com

We are an independently-owned, non-sterile compounding pharmacy in Irvine, California. We specialize in bio-identical hormones, lowdose naltrexone, numbing creams, dermatology preparations, and new for this year, semaglutide.

Young Goose

Booth #8062

1730 S. Federal Hwy. Ste 301 Delray Beach, Florida 33483 US

Ph: _(754) 216-3826_

Email: service@younggoose.com www.younggoose.com

Young Goose is the world’s first biohacking skincare. Our products aim to elevate the skins NAD+ levels, and activate age-reversing genes (Sirtuins), to stop and reverse signs of aging.

ZEO ScientifiX

Booth #7062

3300 S. University Dr. Ft. Lauderdale, Florida 33328

Ph: (888) 963-7881

Email: jill@zeoscientifix.com www.zeoscientifix.com

Pioneers in the development of science-based technologies utilizing extracellular vesicle therapeutics, ZEO ScientifiX is showcasing a ‘first of its kind’ exosome product called, PPX™. PPX™ is a highly concentrated autologous product that utilizes proprietary high speed centrifugation process to isolate an average of 400B total nanoparticles per 2mL vials. The signature exosomes isolated in PPX™ contain multiple types of different microRNA markers, which have been proven to target damaged cells and reduce inflammation while inducing regeneration at the cellular level.

Zimmer MedizinSystems

Booth #4108

3 Goodyear Ste B Irvine, California 92618

Ph: (800) 327-3576

Email: info@zimmerusa.com www.zimmerusa.com

Zimmer MedizinSystems in Irvine, California, with its parent company based in Neu-Ulm, Germany, has over 50 years of expertise in manufacturing high quality medical devices. Originating as a manufacturer of physiotherapy devices, Zimmer rapidly evolved as a global leader in the aesthetic industry. New to the Aesthetic/Wellness portfolio is magnetic technology for urinary incontinence, electrical body stim for toning and muscle definition, and RF for wrinkles and skin laxity. Visit us at booth 4108 for a product demonstration!

Zizion Group Inc.

Booth #8046

141 NW 20th Street Ste G1

Boca Raton, Florida 33431

Ph: (561) 221-1000

Email: bruce@zizion.com

www.zizion.com

Zizion Group is a medical distribution company with a focus on natural integrative therapies. We bring technologically advanced products, targeted training, and innovative marketing expertise, to empower physicians to expand their practice. We are an endto-end provider, identifying appropriate solutions and deployment methodologies while working with your team to ensure success. You are never considered a customer; you are a valued physician partner.

ZRT Laboratory

Booth #7007

8605 SW Creekside Place Beaverton, Oregon 97008 US

Ph: (866) 600-1636

Email: info@zrtlab.com www.zrtlab.com

ZRT Laboratory is a CLIA-certified commercial and research laboratory. ZRT has pioneered innovative testing methods for hormones, neurotransmitters, heavy metals and more, offering health care professionals convenient testing options in different body fluids including saliva, dried blood spot, dried urine, and serum. ZRT is the recognized leader in at-home saliva and dried blood spot collection methods for hormone and wellness testing. We proudly hold the distinction of being the lab that developed dried urine testing for hormones.

Ph: (801) 224-7199

Email: sales@zyto.com

www.zyto.com

ZYTO strives to empower personal wellness through innovative technologies, education, and improved application with a focus on functional, emotional, and energetic elements. The innovative ZYTO scan technology facilitates an interface between a computer and the human body. As a result of this innovative process, suggestions for wellness products and services are provided with the aim at improving a person’s quality of life.

ZYTO

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